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106. Introduction

Author

Petersen, Timothy J., E. Sprich, Susan, Wilhelm, Sabine, Rosenbaum, Jerrold F., Series editor, Petersen, Timothy J., editor, E. Sprich, Susan, editor, and Wilhelm, Sabine, editor

Published
2016
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109. A cluster analysis of tic symptoms in children and adults with Tourette syndrome: Clinical correlates and treatment outcome

Author

McGuire, Joseph F, Nyirabahizi, Epiphanie, Kircanski, Katharina, Piacentini, John, Peterson, Alan L, Woods, Douglas W, Wilhelm, Sabine, Walkup, John T, and Scahill, Lawrence

Subjects
Brain Disorders, Tourette Syndrome, Neurodegenerative, Clinical Trials and Supportive Activities, Mental Health, Serious Mental Illness, Pediatric, Clinical Research, Adolescent, Adult, Behavior Therapy, Child, Cluster Analysis, Female, Humans, Male, Severity of Illness Index, Tic Disorders, Tics, Treatment Outcome, Habit reversal training, Comprehensive behavioral intervention for tics, Tic symptom profiles, Chronic tic disorders, Treatment outcome, Cluster analysis, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

Cluster analytic methods have examined the symptom presentation of chronic tic disorders (CTDs), with limited agreement across studies. The present study investigated patterns, clinical correlates, and treatment outcome of tic symptoms. 239 youth and adults with CTDs completed a battery of assessments at baseline to determine diagnoses, tic severity, and clinical characteristics. Participants were randomly assigned to receive either a comprehensive behavioral intervention for tics (CBIT) or psychoeducation and supportive therapy (PST). A cluster analysis was conducted on the baseline Yale Global Tic Severity Scale (YGTSS) symptom checklist to identify the constellations of tic symptoms. Four tic clusters were identified: Impulse Control and Complex Phonic Tics; Complex Motor Tics; Simple Head Motor/Vocal Tics; and Primarily Simple Motor Tics. Frequencies of tic symptoms showed few differences across youth and adults. Tic clusters had small associations with clinical characteristics and showed no associations to the presence of coexisting psychiatric conditions. Cluster membership scores did not predict treatment response to CBIT or tic severity reductions. Tic symptoms distinctly cluster with little difference across youth and adults, or coexisting conditions. This study, which is the first to examine tic clusters and response to treatment, suggested that tic symptom profiles respond equally well to CBIT. Clinical trials.gov. identifiers: NCT00218777; NCT00231985.

Published
2013

110. Detecting a clinically meaningful change in tic severity in Tourette syndrome: A comparison of three methods

Author

Jeon, Sangchoon, Walkup, John T, Woods, Douglas W, Peterson, Alan, Piacentini, John, Wilhelm, Sabine, Katsovich, Lily, McGuire, Joseph F, Dziura, James, and Scahill, Lawrence

Subjects
Behavioral and Social Science, Clinical Trials and Supportive Activities, Clinical Research, Adolescent, Adult, Aged, Behavior Therapy, Child, Humans, Male, Middle Aged, Severity of Illness Index, Tics, Tourette Syndrome, Treatment Outcome, Young Adult, Clinical Global Impression, Cognitive behavioral intervention, Mixture model, Signal detection analysis, Tourette syndrome, Yale Global Tic Severity Scale, Medical and Health Sciences, General Clinical Medicine, Public Health
Abstract

ObjectiveTo compare three statistical strategies for classifying positive treatment response based on a dimensional measure (Yale Global Tic Severity Scale [YGTSS]) and a categorical measure (Clinical Global Impression-Improvement [CGI-I] scale).MethodSubjects (N=232; 69.4% male; ages 9-69years) with Tourette syndrome or chronic tic disorder participated in one of two 10-week, randomized controlled trials comparing behavioral treatment to supportive therapy. The YGTSS and CGI-I were rated by clinicians blind to treatment assignment. We examined the percent reduction in the YGTSS-Total Tic Score (TTS) against Much Improved or Very Much Improved on the CGI-I, computed a signal detection analysis (SDA) and built a mixture model to classify dimensional response based on the change in the YGTSS-TTS.ResultsA 25% decrease on the YGTSS-TTS predicted positive response on the CGI-I during the trial. The SDA showed that a 25% reduction in the YGTSS-TTS provided optimal sensitivity (87%) and specificity (84%) for predicting positive response. Using a mixture model without consideration of the CGI-I, the dimensional response was defined by 23% (or greater) reduction on the YGTSS-TTS. The odds ratio (OR) of positive response (OR=5.68, 95% CI=[2.99, 10.78]) on the CGI-I for behavioral intervention was greater than the dimensional response (OR=2.86, 95% CI=[1.65, 4.99]).ConclusionA 25% reduction on the YGTSS-TTS is highly predictive of positive response by all three analytic methods. For trained raters, however, tic severity alone does not drive the classification of positive response. Clinicaltrials.gov identifiers: NCT00218777; NCT00231985.

Published
2013

116. Body dysmorphic disorder: a treatment synthesis and consensus on behalf of the International College of Obsessive-Compulsive Spectrum Disorders and the Obsessive Compulsive and Related Disorders Network of the European College of Neuropsychopharmacology

Author

Castle, David, Beilharz, Francesca, Phillips, Katharine A., Brakoulias, Vlasios, Drummond, Lynne M., Hollander, Eric, Ioannidis, Konstantinos, Pallanti, Stefano, Chamberlain, Samuel R., Rossell, Susan L., Veale, David, Wilhelm, Sabine, Van Ameringen, Michael, Dell’Osso, Bernardo, Menchon, Jose M., and Fineberg, Naomi A.

Published
2021
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118. Feasibility, Acceptability, and Preliminary Efficacy of a Smartphone App–Led Cognitive Behavioral Therapy for Depression Under Therapist Supervision: Open Trial (Preprint)

Author

Wilhelm, Sabine, primary, Bernstein, Emily E, additional, Bentley, Kate H, additional, Snorrason, Ivar, additional, Hoeppner, Susanne S, additional, Klare, Dalton, additional, Greenberg, Jennifer L, additional, Weingarden, Hilary, additional, McCoy, Thomas H, additional, and Harrison, Oliver, additional

Published
2023
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122. Inhibitor of Apoptosis Protein-1 Regulates Tumor Necrosis Factor–Mediated Destruction of Intestinal Epithelial Cells

Author

Grabinger, Thomas, Bode, Konstantin J., Demgenski, Janine, Seitz, Carina, Delgado, M. Eugenia, Kostadinova, Feodora, Reinhold, Cindy, Etemadi, Nima, Wilhelm, Sabine, Schweinlin, Matthias, Hänggi, Kay, Knop, Janin, Hauck, Christof, Walles, Heike, Silke, John, Wajant, Harald, Nachbur, Ueli, W. Wei-Lynn, Wong, and Brunner, Thomas

Published
2017
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