101. Adriamycin versus adriamycin plus cis-diamminedichloroplatinum (DDP) in advanced transitional cell bladder carcinoma. A Southwest Oncology Group study.
- Author
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Gagliano R, Levin H, El-Bolkainy MN, Wilson HE, Stephens RL, Fletcher WS, Rivkin SE, O'Bryan RM, Coltman CA Jr, Saiki JH, Stuckey WJ, Balducci L, Bonnet JD, and Dixon DO
- Subjects
- Cisplatin adverse effects, Doxorubicin adverse effects, Drug Evaluation, Drug Therapy, Combination, Gastrointestinal Diseases chemically induced, Humans, Leukopenia chemically induced, Random Allocation, Carcinoma, Transitional Cell drug therapy, Cisplatin administration & dosage, Doxorubicin administration & dosage, Urinary Bladder Neoplasms drug therapy
- Abstract
Patients with advanced transitional cell bladder carcinoma were randomized to receive either adriamycin alone, or adriamycin plus DDP. Overall response (CR + PR) was 8/41 (19%) for adriamycin alone versus 16/37 (43%) for the combination (p = 0.02). Median response duration was 14 weeks for adriamycin versus 25 weeks for the combination (p = 0.17). Median survival was 28 weeks on adriamycin versus 31 weeks on the combination (p = 0.82). Median survival of responders was 43 weeks, and for patients with stable disease it was 29 weeks. This was significantly better than for those with increasing disease at 15 weeks (p = 0.02). Increased frequency of leukopenia and gastrointestinal toxicity were seen with the combination. Cardiotoxicity and nephrotoxicity were not prohibitive.
- Published
- 1983
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