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Iron is an essential element for most organisms. Both plants and microorganisms have developed different mechanisms for iron uptake, transport and storage. In the symbiosis systems, such as rhizobia–legume symbiosis and arbuscular mycorrhizal (AM) symbiosis, maintaining iron homeostasis to meet the requirements for the interaction between the host plants and the symbiotic microbes is a new challenge. This intriguing topic has drawn the attention of many botanists and microbiologists, and many discoveries have been achieved so far. In this review, we discuss the current progress on iron uptake and transport in the nodules and iron homeostasis in rhizobia–legume symbiosis. The discoveries with regard to iron uptake in AM fungi, iron uptake regulation in AM plants and interactions between iron and other nutrient elements during AM symbiosis are also summarized. At the end of this review, we propose prospects for future studies in this fascinating research area. [ABSTRACT FROM AUTHOR]

In mobile devices such as aircraft and electric vehicles, due to limited space, there are strict requirements on the volume and weight of the compressor mounted on the vehicle. Therefore, high-speed scroll compressors have attracted more and more attention because of their small size and light weight. In this paper, the numerical calculations and analysis of the three-dimensional (3D) transient flows in a high-speed scroll refrigeration compressor were established and validated. Circumferential gas intake was used in the simulation. According to the actual compressor size, the mesh generation accurately considers clearances. The radial and the axial clearances were both set as 0.01 mm. A dynamic and high-quality hexahedral structured mesh was generated for the working chamber, and the problem of insufficient grid density in radial clearance was solved. When the rotational speed was set as 3000 rpm, 6000 rpm, and 9000 rpm alternatively, the difference in the volume efficiency of the simulation and the experiment results was below 6.3%. The results show that the higher rotational speed contributed to the greater pressure fluctuation in the compression chamber and the discharge process, and the over-compression phenomenon was more obvious. The maximum leakage velocity was 160 m/s, and the tangential leakage velocity was higher than the radial leakage velocity. Meanwhile, radial leakage velocity will increase significantly in high-speed operation mode. With the increasing rotational speed, the position of the maximum axial and tangential leakage velocity was closer to the start of the scroll. Therefore, the seal of the scroll starting part is very important in the design of a high-speed scroll compressor. [ABSTRACT FROM AUTHOR]

Background and objective: Nationally representative reports on the characteristics and long‐term survival of pulmonary arterial hypertension (PAH) from developing countries are scarce. The applicability of the current main risk stratifications and the longitudinal changes in goal‐oriented treatments have yet to be elucidated in real‐world settings. Therefore, we aimed to provide insights into the characteristics, goal‐oriented treatments and survival of PAH in China and to explore the applicability of the main risk stratifications in our independent cohort. Methods: PAH patients were consecutively enrolled from a national prospective multicentre registry. Data on baseline, follow‐up re‐evaluation and therapeutic changes were collected. Results: A total of 2031 patients were enrolled, with congenital heart disease (CHD)‐PAH (45.2%) being the most common aetiology. The mean age was 35 ± 12 years, and 76.2% were females. At baseline, approximately 20% of the patients with intermediate or high risk received combination treatment. At follow‐up, approximately half of the re‐evaluated patients did not achieve low‐risk profiles, and even among patients who received combination therapy at baseline, 4% of them still worsened. The rate of combination therapy increased significantly from 6.7% before 2015 to 35.5% thereafter. The main risk assessment tools demonstrated good performance for predicting survival both at baseline and at follow‐up. Conclusion: Chinese PAH patients show both similar and distinct features compared to other countries. Current main risk stratifications can significantly discriminate patients at different risk levels. There were still many patients not achieving low‐risk profiles at follow‐up, indicating more aggressive treatment should be implemented to optimize the goal‐oriented treatment strategy. This Chinese registry study revealed that Chinese patients with pulmonary arterial hypertension showed both similar and distinct features compared to other countries. Many patients did not achieve low‐risk profiles at follow‐up, indicating more aggressive treatment should be implemented to optimize goal‐oriented therapy for these patients. [ABSTRACT FROM AUTHOR]

Oxidative stress impairs functional recovery after intracerebral hemorrhage (ICH). Histone deacetylase 6 (HDAC6) plays an important role in the initiation of oxidative stress. However, the function of HDAC6 in ICH and the underlying mechanism of action remain elusive. We demonstrated here that HDAC6 knockout mice were resistant to oxidative stress following ICH, as assessed by the MDA and NADPH/NADP+ assays and ROS detection. HDAC6 deficiency also resulted in reduced neuronal apoptosis and lower expression levels of apoptosis-related proteins. Further mechanistic studies showed that HDAC6 bound to malate dehydrogenase 1 (MDH1) and mediated-MDH1 deacetylation on the lysine residues at position 121 and 298. MDH1 acetylation was inhibited in HT22 cells that were challenged with ICH-related damaging agents (Hemin, Hemoglobin, and Thrombin), but increased when HDAC6 was inhibited, suggesting an interplay between HDAC6 and MDH1. The acetylation-mimetic mutant, but not the acetylation-resistant mutant, of MDH1 protected neurons from oxidative injury. Furthermore, HDAC6 inhibition failed to alleviate brain damage after ICH when MDH1 was knockdown. Taken together, our study showed that HDAC6 inhibition protects against brain damage during ICH through MDH1 acetylation. [ABSTRACT FROM AUTHOR]