101. bsh1 Gene of Lactobacillus plantarumAR113 Plays an Important Role in Ameliorating Western Diet-Aggravated Colitis
- Author
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Shao, Junlin, Mu, Zhiyong, Xia, Yongjun, Xiong, Zhiqiang, Song, Xin, Yang, Yijin, Zhang, Hui, Ai, Lianzhong, and Wang, Guangqiang
- Abstract
Western diet is thought to increase susceptibility to inflammatory bowel disease (IBD), and probiotics are a potential therapeutic agent for IBD. This study revealed the effects of Lactobacillus plantarumAR113 and L. plantarumAR113Δbsh1 on a dextran sulfate sodium (DSS)-induced colitis mouse model under the Western diet (WD). After four weeks of WD and low-sugar and low-fat diet (LD) intervention, induction with 3% DSS, and intragastric administration of probiotics, we found that L. plantarumAR113 could regulate blood glucose and lipid levels and have a certain protective effect on hepatocytes. Our results suggested that the L. plantarumAR113 alleviated DSS-induced colitis under the Western diet by improving dyslipidemia, repairing intestinal barrier dysfunction, and inhibiting the TLR4/Myd88/TRAF-6/NF-κB inflammatory pathway. However, these changes were not demonstrated in the L. plantarumAR113Δbsh1, and therefore, we reasoned that the presence of bsh1 may play a crucial role in the L. plantarumAR113 exerting its anti-inflammatory function. The relationship between bile salt hydrolase (BSH) and colitis was worthy of further exploration.
- Published
- 2023
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