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Chlorophyll content is a physiological index widely used in the research of botany and agriculture. It is closely associated with leaf photosynthetic function. The current methods cannot simultaneously determine chlorophyll content and photosynthetic function and analyze their correlation. To solve this problem, we measured the SPAD value and chlorophyll fluorescence induction kinetic curve with 35 wheat varieties. We established a linear regression model using the fluorescence values of the fast chlorophyll fluorescence kinetic curve at different times, 33 common fluorescence parameters, and the correlation between the parameters and the SPAD values. We further verified the model using laboratory and field data. Our results showed that the linear model based on chlorophyll fluorescence parameter叶绿素含量是植物学和农业相关研究领域常用的生理指标。叶绿素含量和叶片光合功能密切相关,但是现有的叶绿素含量的测定方法无法实现叶绿素含量和光合功能的同步测定和关联分析。为解决该问题,本研究通过测定35个小麦品种旗叶的SPAD值和叶绿素荧光诱导动力学曲线,分别使用不同时间的快速叶绿素荧光动力学曲线的荧光值,以及33个常用荧光参数与对应叶片的SPAD值进行相关性分析,建立线性回归模型,并使用室内和大田两组数据对回归模型进行验证。结果表明: 通过叶绿素荧光参数

So far quite a few ultraluminous X-ray (ULX) pulsars have been discovered. In this work, we construct a super-Eddington, magnetic accretion disk model to estimate the dipole magnetic field of eight ULX pulsars based on their observed spin-up variations and luminosities. We obtain two branches of dipole magnetic field solutions. They are distributed in the range of $B\sim (0.16-64.5)\times 10^{10}\,{\rm G}$ and $\sim (0.275-79.0)\times 10^{13}\,{\rm G}$ corresponding to the low- and high-$B$ solutions respectively. The low magnetic field solutions correspond to the state that the neutron stars are far away from the spin equilibrium, and the high magnetic field solutions are close to the spin equilibrium. The ultra-strong magnetic fields derived in Be-type ULX pulsars imply that the accretion mode in Be-type ULX pulsars could be more complicated than in the persistent ULX pulsars and may not be accounted for by the magnetized accretion disk model. We suggest that the transition between the accretor and the propeller regimes may be used to distinguish between the low- and high-$B$ magnetic field solutions in addition to the detection of the cyclotron resonance scattering features., Comment: 15 pages, 3 figures and 2 tables; Accepted for publication in RAA

We perform a systematic study of merging black hole (BH) binaries with compact star (CS) companions, including black hole--white dwarf (BH--WD), black hole--neutron star (BH--NS) and black hole--black hole (BH--BH) systems. Previous studies have shown that mass transfer stability and common envelope evolution can significantly affect the formation of merging BH--CS binaries through isolated binary evolution. With detailed binary evolution simulations, we obtain easy-to-use criteria for the occurrence of the common envelope phase in mass-transferring BH binaries with a nondegenerate donor, and incorporate into population synthesis calculations. To explore the impact of possible mass gap between NSs and BHs on the properties of merging BH--CS binary population, we adopt different supernova mechanisms involving the \textit{rapid}, \textit{delayed} and \textit{stochastic} prescriptions to deal with the compact remnant masses and the natal kicks. Our calculations show that there are $ \sim 10^{5} -10^{6}$ BH--CS binaries in the Milky Way, among which dozens are observable by future space-based gravitational wave detectors. We estimate that the local merger rate density of all BH--CS systems is $ \sim 60-200 \,\rm Gpc^{-3}yr^{-1}$. While there are no low-mass BHs formed via \textit{rapid} supernovae, both \textit{delayed} and \textit{stochastic} prescriptions predict that $ \sim 100\% $/$ \sim 70\% $/$ \sim 30\% $ of merging BH--WD/BH--NS/BH--BH binaries are likely to have BH components within the mass gap., Comment: 21 pages, 12 figures, 1 table, submitted to ApJ after incorporating referee's comments

Chronically SHIV

BACKGROUND The pandemic of coronavirus disease 2019 (COVID-19) has become a major public health challenge all over the world. People's knowledge, attitudes, and preventive behaviors about diseases affect the degree of adherence to control measures. This study aimed to survey the affecting factors of COVID-19 prevention behavior among nursing students in China. MATERIAL AND METHODS Six-hundred thirteen nursing students in Anhui, China participated in an online survey from March 30 to April 5, 2020. The survey collected demographic information, electronic health (eHealth) literacy, COVID-19-related knowledge, attitudes, and prevention behavior data using descriptive analysis and multinomial logistic regression to analyze the data. RESULTS The mean age of study participants was 20.88 years, of which 31.8% were male (n=613). Television (84.9%) and WeChat (79.6%) were the major sources of their information. Nursing students had good knowledge (14.68±2.83), had positive attitudes (4.03±0.59), had good practices (3.92±0.65), and had basic eHealth literacy (30.45±6.90). Nursing students with higher eHealth literacy (odds ratio [OR]=0.89, P

Using X-ray sources as sensitive probes of stellar dynamical interactions in globular clusters (GCs), we study the mass segregation and binary burning processes in $\omega$ Cen. We show that the mass segregation of X-ray sources is quenched in $\omega$ Cen, while the X-ray source abundance of $\omega$ Cen is much smaller than other GCs, and the binary hardness ratio (defined as $L_{\rm X}/(L_{\rm K}f_{b})$, with $f_{b}$ the binary fraction, $L_{\rm X}$ and $L_{\rm K}$ the cumulative X-ray and K band luminosity of GCs, respectively) of $\omega$ Cen is located far below the $L_{\rm X}/(L_{\rm K}f_{b})-\sigma_{c}$ correlation line of the dynamically normal GCs. These evidences suggest that the binary burning processes are highly suppressed in $\omega$ Cen, and other "heating mechanisms", very likely a black hole subsystem (BHS), are essential in the dynamical evolution of $\omega$ Cen. Through the "black hole burning" processes (i.e., dynamical hardening of the BH binaries), the BHS is dominating the energy production of $\omega$ Cen, which also makes $\omega$ Cen a promising factory of gravitational-wave sources in the Galaxy., Comment: 13 pages, 3 figures, 1 table. Accepted for publication in ApJ

Strains MS586T and MS82, which are aerobic, Gram‐negative, rod‐shaped, and polar‐flagellated bacteria, were isolated from the soybean rhizosphere in Mississippi. Taxonomic positions of MS586T and MS82 were determined using a polyphasic approach. 16S rRNA gene sequence analyses of the two strains showed high pairwise sequence similarities (>98%) to some Pseudomonas species. Analysis of the concatenated 16S rRNA, rpoB, rpoD, and gyrB gene sequences indicated that the strains belonging to the Pseudomonas koreensis subgroup (SG) shared the highest similarity with Pseudomonas kribbensis strain 46‐2T. Analyses of average nucleotide identity (ANI), genome‐to‐genome distance, delineated MS586T and MS82 from other species within the genus Pseudomonas. The predominant quinone system of the strain was ubiquinone 9 (Q‐9), and the DNA G+C content was 60.48 mol%. The major fatty acids were C16:0, C17:0 cyclo, and the summed features 3 and 8 consisting of C16:1ω7c/C16:1ω6c and C18:1ω7c/C18:1ω6c, respectively. The major polar lipids were phosphatidylglycerol, phosphatidylethanolamine, and diphosphatidylglycerol. Based on these data, it is proposed that strains MS586T and MS82 represent a novel species within the genus Pseudomonas. The proposed name for the new species is Pseudomonas glycinae, and the type strain is MS586T (accession NRRL B‐65441 = accession LMG 30275)., Bacterial strains MS586T and MS82 were isolated from soybean rhizosphere in Mississippi. Both strains exhibited striking antimicrobial activity. According to analyses of phylogenetic, phenotypic, physiological, biochemical, and chemotaxonomic characteristics, strains MS586T and MS82 represent a novel species of the genus Pseudomonas, which belongs to the Pseudomonas koreensis subgroup. The proposed name for the new species is Pseudomonas glycinae, and the type strain is MS586T.

Coat proteins (CPs) play critical roles in potyvirus cell‐to‐cell movement. However, the underlying mechanism controlling them remains unclear. Here, we show that substitutions of alanine, glutamic acid, or lysine for the conserved residue tryptophan at position 122 (W122) in tobacco vein banding mosaic virus (TVBMV) CP abolished virus cell‐to‐cell movement in Nicotiana benthamiana plants. In agroinfiltrated N. benthamiana leaf patches, both the CP and RNA accumulation levels of three W122 mutant viruses were significantly reduced compared with those of wild‐type TVBMV, and CP accumulated to a low level similar to that of a replication‐deficient mutant. The results of polyprotein transient expression experiments indicated that CP instability was responsible for the significantly low CP accumulation levels of the three W122 mutant viruses. The substitution of W122 did not affect CP plasmodesmata localization or virus particle formation; however, the substitution significantly reduced the number of virus particles. The wild‐type TVBMV CP could complement the reduced replication and abolished cell‐to‐cell movement of the mutant viruses. When the codon for W122 was mutated to that for a different aromatic residue, phenylalanine or tyrosine, the resultant mutant viruses moved systemically and accumulated up to 80% of the wild‐type TVBMV level. Similar results were obtained for the corresponding amino acids of W122 in the watermelon mosaic virus and potato virus Y CPs. Therefore, we conclude that the aromatic ring in W122 in the core domain of the potyviral CP is critical for cell‐to‐cell movement through the effects on CP stability and viral replication., The aromatic ring of W122 and corresponding residues is crucial for the coat protein stability, replication, and cell‐to‐cell movement of potyviruses.

To analyze the pathological characteristics and explore the optimal surgical margins (SM) of nephron-sparing surgery (NSS) for stage TThe clinical and pathological data of 245 cases of stage TThrough postoperative pathological examination, 209 (85.3%) cases were confirmed renal clear cell carcinoma and 219 (89.4%) cases were surrounded with visible peritumoralpseudocapsule (PC). 26 (10.6%) cases of cancerous cells invaded beyond peritumoral PC and into renal parenchyma. The infiltrative depth into renal parenchyma beyond PC was all limited in 3 mm and the cases of ≤1, 1-2 and 2-3 mm were 7 (26.9%), 16 (61.5%) and 3 (11.5%), respectively. Multifocal tumors were discovered in 24 (9.8%) cases. The average resection margin for partial nephrectomy was 5 mm (3-7 mm).For stage T

There is accumulating evidence that scalar fields may exist in nature. The gravitational collapse of a boson cloud leads to the formation of a boson star just like white dwarfs and neutron stars. In general, as one of the candidates of dark matter, a boson star holds a stable configuration and has deserved intensive attention and extensive research in the past 50years. At first, we analyze the ground state solutions for a Boson-Fermi system using the metric tensor in the Newtonian approximation, then analyze the configuration of a star composed of bosons and fermions. At last, for the purpose of investigating the equilibrium geometry of a Boson-Fermi system, we construct the virial equations of a boson-Fermi system with different orders. In our future work, we will explore the equilibrium configuration and the stability of a Boson-Fermi star and how a scalar field affects the pressure of the system using higher-order virial equations of fluid motions.

SS433 is an extraordinary X-ray binary which is ejecting bipolar jets with $26\%$ of the speed of light. Associated with the supernova-like shell W50, SS433 is also probably one of the youngest X-ray binaries with an age of $\lesssim 10^5$ yr. However, the masses of the two components in SS433 and even the nature of the compact object are still under debate. In this work, assuming that the compact object is a black hole, we employ a binary population synthesis method to study the formation of SS433. We use previous estimates of the age of W50 and the duration of the jet activity to constrain the evolutionary history. Our calculations suggest that SS433 likely harboured a Hertzsprung gap star at the beginning of the current Roche-lobe overflow phase. The masses of the black hole and the optical/donor star in SS433 suggested by the simulations are around $8\ M_{\odot}$ and $24\ M_{\odot}$, respectively. Future measurement of the donor mass and radius can help infer not only the orgin of the binary but also the nature of the nebula W50., Comment: 13 pages, 7 figures, accepted for publication in ApJ

Chromatin dynamics regulated by epigenetic modification is crucial in genome stability and gene expression. Various epigenetic mechanisms have been identified in the pathogenesis of human diseases. Here, we examined the effects of ten epigenetic agents on pseudorabies virus (PRV) infection by using GFP-reporter assays. Inhibitors of bromodomain protein 4 (BRD4), which receives much more attention in cancer than viral infection, was found to exhibit substantial anti-viral activity against PRV as well as a range of DNA and RNA viruses. We further demonstrated that BRD4 inhibition boosted a robust innate immune response. BRD4 inhibition also de-compacted chromatin structure and induced the DNA damage response, thereby triggering the activation of cGAS-mediated innate immunity and increasing host resistance to viral infection both in vitro and in vivo. Mechanistically, the inhibitory effect of BRD4 inhibition on viral infection was mainly attributed to the attenuation of viral attachment. Our findings reveal a unique mechanism through which BRD4 inhibition restrains viral infection and points to its potent therapeutic value for viral infectious diseases., Author summary BRD4 has been well investigated in tumorigenesis for its contribution to chromatin remodeling and gene transcription. BRD4 inhibitors are used as promising chemotherapeutic drugs for cancer therapy. Here, we show a unique mechanism through which BRD4 inhibition broadly inhibits attachment of DNA and RNA viruses through DNA damage-dependent antiviral innate immune activation via the cGAS-STING pathway, in both cell culture and an animal model. STING-associated innate immune signaling has been considered to be a new possibility for cancer therapy, and STING agonists have been tested in early clinical trials. Our data identify BRD4 inhibitors as a potent therapy not only for viral infection but also for cancer immunotherapy.

The distribution of the mass of white dwarfs (WDs) is one of the fundamental questions in the field of cataclysmic variables (CVs). In this work, we make a systematical investigation on the WD masses in two subclass of CVs: intermediate polars (IPs) and non-magnetic CVs in the solar vicinity based on the flux ratios of Fe xxvi–Lyα to Fe xxv–Heα emission lines (I 7.0/I 6.7) from archival XMM-Newton and Suzaku observations. We first verify the (semi-empirical) relations between I 7.0/I 6.7, the maximum emission temperature (T max) and the WD mass (M WD) with the mkcflow model based on the apec description and the latest AtomDB. We then introduce a new spectral model to measure M WD directly based on the above relations. A comparison shows that the derived M WD is consistent with dynamically measured ones. Finally, we obtain the average WD masses of 58 CVs (including 36 IPs and 22 non-magnetic CVs), which is the largest X-ray selected sample. The average WD masses are 〈M WD,IP〉 = 0.81 ± 0.21 M ⊙ and 〈 M WD , DN 〉 = 0.81 ± 0.21 M ⊙ for IPs and non-magnetic CVs, respectively. These results are consistent with previous works.

Objective: This study aimed to evaluate the diagnostic value of positron emission tomography/computed tomography(PET/CT) for detecting the infective lesions in patients with extrapulmonary tuberculosis (EPTB). Methods: The PET/CT imaging findings of 46 patients with extrapulmonary tuberculosis were analyzed retrospectively. Of the 46 patients, the standard uptake value (SUV) was calculated, and the maximum SUV (SUVmax) was measured. Characteristic imaging findings and SUV of EPTB in PET/CT were summarized. Results: PET/CT demonstrated different degrees of increased 18F-FDG uptake in EPTB patients, with the SUVmax ranging from 1.3 to 30.0. Based on the involved organ and tissue, there were 4 types of lesions, including lymph node tuberculosis (25 cases), membranous tuberculosis (13 cases), organ tuberculosis (13 cases) and osteoarticular tuberculosis (8 cases). Of the 46 cases, 11 had two or more than two types of lesions. In the 25 cases of lymph node tuberculosis, slight or moderate lymphadenopathy were revealed by CT, and nodular or mass-like increased 18F-FDG uptake were found by PET, with SUVmax ranged from 3.0 to 30.0. In the 13 cases of membranous tuberculosis, the lesions involved meninx, pericardium, pleura and peritoneum. And PET/CT demonstrated different degrees of membranous thickening, with the SUVmax ranging from 1.3 to 14.5. In the 13 cases of organ tuberculosis, the lesion involved liver, spleen, pancreas, colon, prostate, seminal vesicle and ovary, with the SUVmax ranging from 2.5 to 15.6. In the 8 cases of osteoarticular tuberculosis, osteolytic bone destruction was found. The lesions showed increased 18F-FDG uptake on the PET/CT, with SUVmax ranging from 3.5 to 19.2. Conclusion: There were some imaging characteristics of EPTB by PET/CT. PET/CT can accurately demonstrate the pathological morphology, extent of involvement and uptake activity of EPTB, and provided information in accurate diagnosis, differential diagnosis and assessment of treatment response of EPTB. Keywords: Extrapulmonary tuberculosis, X-ray, Computed tomography, Positron emission tomography

We summarize our model that high frequency quasi-periodic oscillations (QPOs) both in the neutron star low mass X-ray binaries (NS-LMXBs) and black hole LMXBs may originate from magnetohydrodynamic (MHD) waves. Based on the MHD model in NS-LMXBs, the explanation of the parallel tracks is presented. The slowly varying effective surface magnetic field of a NS leads to the shift of parallel tracks of QPOs in NS-LMXBs. In the study of kilohertz (kHz) QPOs in NS-LMXBs, we obtain a simple power-law relation between the kHz QPO frequencies and the combined parameter of accretion rate and the effective surface magnetic field. Based on the MHD model in BH-LMXBs, we suggest that two stable modes of the Alfv́en waves in the accretion disks with a toroidal magnetic field may lead to the double high frequency QPOs. This model, in which the effect of the general relativity in BH-LMXBs is considered, naturally accounts for the 3:2 relation for the upper and lower frequencies of the QPOs and the relation between the BH mass and QPO frequency.

The white dwarf (WD) + helium (He) star binary channel plays an important role in the single degenerate scenario for the progenitors of type Ia supernovae (SNe Ia). Previous studies on the WD + main sequence star evolution have shown that the magnetic fields of WDs may significantly influence their accretion and nuclear burning processes. In this work we focus on the evolution of magnetized WD + He star binaries with detailed stellar evolution and binary population synthesis (BPS) calculations. In the case of magnetized WDs, the magnetic fields may disrupt the inner regions of the accretion disk, funnel the accretion flow onto the polar caps, and even confine helium burning within the caps.We find that, for WDs with sufficiently strong magnetic fields, the parameter space of the potential SN Ia progenitor systems shrinks toward shorter orbital periods and lower donor masses compared with that in the non-magnetized WD case. The reason is that the magnetic confinement usually works with relatively high mass transfer rates, which can trigger strong wind mass loss from the WD, thus limiting the He-rich mass accumulation efficiency. The surviving companion stars are likely of low-mass at the moment of the SN explosions, which can be regarded as a possible explanation for the non-detection of surviving companions after the SNe or inside the SN remnants. However, the corresponding birthrate of Galactic SNe Ia in our high-magnetic models is estimated to be ~(0.08-0.13) * 10^{-3} yr^{-1}( ~0.17-0.28 * 10^{-3}yr^{-1} for the non-magnetic models), significantly lower than the observed Galactic SN Ia birthrate., Comment: 25 pages, 15 figures

Magnetars form a special population of neutron stars with strong magnetic fields and long spin periods. About 30 magnetars and magnetar candidates known currently are probably isolated, but the possibility that magnetars are in binaries has not been excluded. In this work, we perform spin evolution of neutron stars with different magnetic fields in wind-fed high-mass X-ray binaries and compare the spin period distribution with observations, aiming to find magnetars in binaries. Our simulation shows that some of the neutron stars, which have long spin periods or are in widely-separated systems, need strong magnetic fields to explain their spin evolution. This implies that there are probably magnetars in high-mass X-ray binaries. Moreover, this can further provide a theoretical basis for some unclear astronomical phenomena, such as the possible origin of periodic fast radio bursts from magnetars in binary systems.

The Hubble Space Telescope observation of the double white dwarf (WD) binary SDSS J125733.63$+$542850.5 reveal that the massive WD has a surface gravity log$g_1\sim8.7$ (which implies a mass of $M_1\sim1.06~{\rm M_\odot}$) and an effective temperature $T_1\sim13000$ K, while the effective temperature of the low-mass WD ($M_2

This paper deals with the problem of iterative learning control algorithm for consensus of a class of multi-agent systems, and all the agents in the considered systems are governed by the nonlinear dynamics with quasi-one-sided Lipschitz condition. Based on the framework of network topologies, distributed consensus-based iterative learning control protocols are designed by using the nearest neighbor knowledge. Under the action of the iterative learning control law, consensus on the finite time interval along the iteration axis can be reached for all the directed communication graphs with spanning trees. A simulation example is finally used to illustrate the effectiveness of the proposed approach.

Neutron star X-ray binaries (NS XRBs) associated with supernova remnants (SNRs) are the youngest X-ray binaries that can provide insights into the early evolution of X-ray binaries and the formation properties of neutron stars. There are an increasing number of NS XRBs discovered to be harbored in SNRs in our and nearby galaxies. In this work, we perform binary population synthesis calculations to simulate the population of NS XRBs associated with SNRs for different types of companions, including Roche-lobe overfilling main-sequence stars, Be stars and supergiants. We estimate their birthrates and present the distributions of orbital parameters and companion mass for each type of companions. Our calculations show that the majority of them are Be X-ray binaries (BeXRBs) and that a few BeXRBs are expected to be associated with SNRs in a Milky Way-type galaxy., Comment: Accepted for publication in ApJ

This study aimed to investigate the protective effects of salvianolic acid B (SA-B) on acute lung injury (ALI) through decreasing the expressions of channel kinase's TRPM6 and TRPM7. Wistar Septic rat models were established by lipopolysaccharide (LPS), which were separated into the control, lipopolysaccharide (LPS), SA-B, SA-B + si-TRPM6, SA-B + si-TRPM7, si-TRPM6 and si-TRPM7 groups. Arterial blood gas, protein content, total white blood cell (WBC) count and the percentage of polymorphonuclear neutrophils (PMN%) were measured. Levels of TNF-α and IL-6 levels in bronchoalveolar lavage fluid (BALF) were monitored. Lung coefficient, myeloperoxidase (MPO) and superoxide dismutase (SOD) activity were conducted by MPO and SOD kit. The mRNA expressions of TRPM6 and TRPM7 were detected by qRT-PCR. Compared with the control group, the PaO2 and PaO2/FiO2 values exhibited decreases in other group, while the PaCO2 value, protein content, total WBC, PMN%, TNF-α, IL-6 levels and lung coefficient values all increased. MPO activity in lung tissue increased, while SOD activity decreased. TRPM6 and TRPM7 expressions increased significantly. Compared with the LPS group, the SA-B, SA-B + si-TRPM6, SA-B + si-TRPM7, si-TRPM6 and si-TRPM7 groups had increased PaO2 and the PaO2/FiO2, while decreased PaCO2, protein content, total WBC, PMN%, TNF-α, IL-6 levels, and lung coefficient. MPO activity in lung tissue decreased while SOD activity increased. Decreased mRNA expressions of TRPM6 and TRPM7 in the SA-B, SA-B + si-TRPM6, and SA-B + si-TRPM6 groups were observed. Through decreasing the expressions of the channel kinase TRPM6 and TRPM7, SA-B protects against ALI in septic rats. This article is protected by copyright. All rights reserved

Blebbistatin is a potent and specific inhibitor of the motor functions of class II myosins, including striated muscle myosin and nonmuscle myosin-2 (NM2). However, the blebbistatin inhibition of NM2c has not been assessed and remains controversial with respect to its efficacy with smooth muscle myosin (SmM), which is highly homologous to NM2. To clarify these issues, we analyzed the effects of blebbistatin on the motor activities of recombinant SmM and three NM2s (NM2a, -2b, and -2c). We found that blebbistatin potently inhibits the actin-activated ATPase activities of SmM and NM2s with following IC50 values: 6.47 μM for SmM, 3.58 μM for NM2a, 2.30 μM for NM2b, and 1.57 μM for NM2c. To identify the blebbistatin-resistant myosin-2 mutant, we performed mutagenesis analysis of the conserved residues in the blebbistatin-binding site of SmM and NM2s. We found that the A456F mutation renders SmM and NM2s resistant to blebbistatin without greatly altering their motor activities or phosphorylation-dependent regul...

Class V myosin (myosin-5) is a molecular motor that functions as an organelle transporter. The activation of myosin-5's motor function has long been known to be associated with a transition from the folded conformation in the off-state to the extended conformation in the on-state, but only recently have we begun to understand the underlying mechanism. The globular tail domain (GTD) of myosin-5 has been identified as the inhibitory domain and has recently been shown to function as a dimer in regulating the motor function. The folded off-state of myosin-5 is stabilized by multiple intramolecular interactions, including head-GTD interactions, GTD-GTD interactions, and interactions between the GTD and the C-terminus of the first coiled-coil segment. Any cellular factor that affects these intramolecular interactions and thus the stability of the folded conformation of myosin-5 would be expected to regulate myosin-5 motor function. Both the adaptor proteins of myosin-5 and Ca2+ are potential regulators of myosin-5 motor function, because they can destabilize its folded conformation. A combination of these regulators provides a versatile scheme in regulating myosin-5 motor function in the cell.

LB-1 was originally suggested to harbour a very massive ($ \sim 70 M_\odot $) black hole, but was recently suggested to be a post-mass transfer binary containing a Be star and a helium (He) star. In this paper, we use the binary population synthesis method to simulate the potential population of the Be$ - $He binaries in the Milky Way. Mass transfer process during the progenitor binary evolution plays a vital role in determining the possible properties of the Be$ - $He binary population. By constructing a range of physical models with significantly different mass-transfer efficiencies, we obtain the predicted distributions at the current epoch of the component masses and the orbital periods for the Be$ - $He binaries. In particular, we show that, LB-1 very likely has evolved through non-conservative mass transfer if it is indeed a Be$ - $He system. We estimate that there are more than $ 10^{3} $ Be$ - $He binaries with V-band apparent magnitudes brighter than LB-1., Comment: 8 pages, 5 figures, accepted by ApJ

The effect of reservoir stimulation is not ideal for HPHT fractured reservoir in Tarim Oilfield, so the main factors affecting the reservoir stimulation and the influence rule were studied, then the efficient stimulation measures were proposed. The development degree and effectiveness of natural fractures are key factors. Geomechanical studies have shown that the main factors affecting natural fractures opening including natural fracture occurrence, reservoir stress, pore pressure increment caused by the stimulation, the angle between maximum principal stress direction and natural fracture orientation, cohesion and so on. High angle natural fractures are prone to shear failure; the greater the pore pressure increment during stimulation, the greater the stress difference between the maximum and minimum horizontal stress, natural fractures are more easily open by shear failure. The smaller the angle between natural fracture strike and the maximum principal stress direction, natural fractures shear failure easily occurs. Cohesion has a greater impact on natural fractures opening rate, lower cohesion can greatly increase the natural fractures opening rate. Cohesion drops from 14 MPa to 0 MPa, natural fractures open rate increases from 11.5% to 71.2%, the crack opening rate increased by 59.7%. Reservoir simulation studies have shown that improve the longitudinal producing degree is better than lateral producing degree to improve well productivity. By temporarily blocking natural fractures, improving pump injection, and acidizing fracture fillers to reduce facture cohesion, the fracture opening rate increases, so then the effect of stimulation are improved greatly. The reservoir stimulation countermeasures are an efficient way to yield higher production in ultra-deep fractured reservoir.

PSR J1640+2224 is a binary millisecond pulsar (BMSP) with a white dwarf (WD) companion. Recent observations indicate that the WD is very likely to be a $\sim 0.7\,M_{\odot}$ CO WD. Thus the BMSP should have evolved from an intermediate-mass X-ray binary (IMXB). However, previous investigations on IMXB evolution predict that the orbital periods of the resultant BMSPs are generally $2.0\,M_{\odot}$)., 24 pages, 5 figures, accepted for publication in ApJ

Using archival {\it Chandra} observations with a total effective exposure of 323 ks, we derive an updated catalog of point sources in the bulge globular cluster M28. The catalog contains 502 X-ray sources within an area of $\sim475\, \rm arcmin^{2}$, and more than $90\%$ of these sources are first detected in this cluster. We find significant dips in the radial distribution profiles of X-ray sources in M28, with the projected distance and width of the distribution dip for bright ($L_{X} \gtrsim 4.5\times 10^{30} {\rm\ erg\ \,s^{-1}}$) X-ray sources are larger than the faint ($L_{X} \lesssim 4.5\times 10^{30} {\rm\ erg\ \,s^{-1}}$) sources. The "generalized King model" fitting give a slightly larger average mass for the bright sources ($1.30\pm0.15\,M_{\odot}$) than the faint sources ($1.09\pm0.14\,M_{\odot}$), which support a universal mass segregation delay between heavy objects in GCs. Compared with 47 Tuc and Terzan 5, we show that the dynamical age of M28 is comparable to Terzan 5 and much smaller than 47 Tuc, but it is evolving more fast (i.e., with smaller two-body relaxation timescale) than 47 Tuc. These features may suggest an acceleration effect of cluster dynamical evolution by tidal shock in M28. Besides, we find an abnormal deficiency of X-ray sources in the central region ($R \lesssim 1.5 \rm~arcmin$) of M28 than its outskirts, which indicate that M28 may have suffered an early phase of primordial binary disruption within its central region, and mass segregation effect will erase such a phenomenon as cluster evolve to older dynamical age., Comment: 18 pages, 5 figures, accepted for publication in ApJ

Most astrophysical accretion disks are likely to be warped. In X-ray binaries, the spin evolution of an accreting neutron star is critically dependent on the interaction between the neutron star magnetic field and the accretion disk. There have been extensive investigations on the accretion torque exerted by a coplanar disk that is magnetically threaded by the magnetic field lines from the neutron stars, but relevant works on warped/tilted accretion disks are still lacking. In this paper we develop a simplified two-component model, in which the disk is comprised of an inner coplanar part and an outer, tilted part. Based on standard assumption on the formation and evolution of the toroidal magnetic field component, we derive the dimensionless torque and show that a warped/titled disk is more likely to spin up the neutron star compared with a coplanar disk. We also discuss the possible influence of various initial parameters on the torque.

All stellar mass black holes have hitherto been identified by X-rays emitted by gas that is accreting onto the black hole from a companion star. These systems are all binaries with black holes below 30 M$_{\odot}$$^{1-4}$. Theory predicts, however, that X-ray emitting systems form a minority of the total population of star-black hole binaries$^{5,6}$. When the black hole is not accreting gas, it can be found through radial velocity measurements of the motion of the companion star. Here we report radial velocity measurements of a Galactic star, LB-1, which is a B-type star, taken over two years. We find that the motion of the B-star and an accompanying H$\alpha$ emission line require the presence of a dark companion with a mass of $68^{+11}_{-13}$ M$_{\odot}$, which can only be a black hole. The long orbital period of 78.9 days shows that this is a wide binary system. The gravitational wave experiments have detected similarly massive black holes$^{7,8}$, but forming such massive ones in a high-metallicity environment would be extremely challenging to current stellar evolution theories$^{9-11}$., Comment: Published in Nature on Nov 28, 2019

Two accretion columns have been argued to form over the surface of a newborn millisecond magnetar for an extremely high accretion rate $\gtrsim1.8\times10^{-2}M_\odot\ {\rm s^{-1}}$ that may occur in the core-collapse of a massive star. In this paper, we investigate the characteristics of these accretion columns and their gravitational wave (GW) radiation. For a typical millisecond magnetar (surface magnetic field strength $B\sim10^{15}$ G and initial spin period $P\sim1$ ms), we find (1) its accretion columns are cooled via neutrinos and can reach a height $\sim1$ km over the stellar surface; (2) its column-induced characteristic GW strain is comparable to the sensitivities of the next generation ground-based GW detectors within a horizon $\sim1$ Mpc; (3) the magnetar can survive only a few tens of seconds; (4) during the survival timescale, the height of the accretion columns increases rapidly to the peak and subsequently decreases slowly; (5) the column mass, characteristic GW strain, and maximum GW luminosity have simultaneous peaks in a similar rise-fall evolution. In addition, we find that the magnetar's spin evolution is dominated by the column accretion torque. A possible association with failed supernova is also discussed., 8 pages, 3 figures, accepted for publication in PRD

Pseudorabies virus (PRV), a veterinary pathogen that infects domestic animals as well as wild animals such as wild boar and feral swine, was recently reported to infect human and led to endophthalmitis and encephalitis. A retrospective seroepidemiologic survey was conducted using 1,335 serum samples collected from patients with encephalitis and ELISA positive rates were 12.16%, 14.25%, and 6.52% in 2012, 2013, and 2017, respectively. The virus neutralizing antibody titers of positive samples correlated well with ELISA results. The pseudorabies virus antibody positive rate of patients with encephalitis were higher than that of healthy people in 2017. The above results suggest that some undefined human encephalitis cases may be caused by PRV infection.

Optical observations of normal-stars in binary systems with massive unseen objects have been proposed to search for candidate black holes (BHs) and provide a direct measurement of their dynamical masses. In this paper, we have performed binary population synthesis calculations to simulate the potential population of detached binaries containing BHs and normal-star companions in the Galaxy. We focus on the influence of the BH progenitors. In the traditional model, BHs in binaries evolve from stars more massive than $ \sim25M_{\odot} $. However, it is difficult for this model to produce BH low-mass X-ray binaries. Recent investigations on massive star evolution suggest that the BH progenitors may have masses as low as $ \sim15M_{\odot} $. Based on this model, we provide the expected distributions of various parameters for detached BH binaries with normal-star companions, including the component masses, the orbital parameters of the binary systems, the radial velocity semi-amplitudes, and the astrometric signatures of the optical companions. %the detached BH systems with low-mass companions can be easily produced in our simulations. Our calculations show that there are more than thousands of such detached binaries in the Galaxy, and hundreds of them are potentially observable systems with luminous companions brighter than 20 mag. In addition, detached BH binaries are dominated by those with main-sequence companions and only a few percent of them are expected to have giant companions., 10 pages, 8 figures, accepted by ApJ

In order to improve the accuracy of face detection, this paper proposes a method based on combination of skin color model and improved Adaboost algorithm. Using skin color model with YCbCr color space to detect the skin color, obtain the area to be detected, and then we can locate accurately the face position with the Adaboost face detection algorithm. Because the traditional Adaboost face detection algorithm needs a long time training and can not effectively distinguish feature values which are aggregated distribution, we have improved Adaboost algorithm based on two-threshold and a new method about suppression of weights updating which which prevents excessive weight gain and avoids the phenomenon of degradation during training in Adaboost.

The flux ratio of Fe XXVI--Ly$\alpha$ to Fe XXV--He$\alpha$ lines ($I_{\rm 7.0}/I_{\rm 6.7}$) is a sensitive indicator of the maximum temperature ($T_{\rm max}$), and therefore the mass of white dwarf stars ($M_{\rm WD}$) in cataclysmic variables (CVs). To examine and calibrate the theoretical $I_{\rm 7.0}/I_{\rm 6.7}$--$T_{\rm max}$--$M_{\rm WD}$ relations, reliable measurements of $T_{\rm max}$ and $I_{\rm 7.0}/I_{\rm 6.7}$ are necessary. In this work, we conduct a thorough investigation on 3--50 keV X-ray spectra of 25 solar neighborhood magnetic and non-magnetic CVs based on archival \textit{NuSTAR} and \textit{Suzaku} observations. The measured $T_{\rm max}$ are compared to the $I_{\rm 7.0}/I_{\rm 6.7}$ and $M_{\rm WD}$. The results show the sampled CVs closely follow the theoretical $I_{\rm 7.0}/I_{\rm 6.7}$--$T_{\rm max}$ relation. Moreover, all the $M_{\rm WD}$ estimated from $I_{\rm 7.0}/I_{\rm 6.7}$ are consistent with the dynamically measured ones. We conclude that $I_{\rm 7.0}/I_{\rm 6.7}$ can be used as a good diagnostic for $T_{\rm max}$ and $M_{\rm WD}$ in both magnetic and non-magnetic CVs., Comment: 15 pages, 4 figures, Accepted for publication in ApJ

Fast radio bursts (FRBs) are mysterious radio transients with millisecond durations. Recently, a periodic activity of $\sim$16 day and a possible periodicity of $\sim$159 day were detected to arise from FRB 180916.J0158+65 and FRB 121102, respectively, and the spin period of a slow-rotation magnetar was further considered to be one of possibilities to explain the periodic activities of repeating FRBs. For isolated neutron stars, the spin evolution suggests that it's difficult to reach several hours. In this work, we mainly focus on the possible maximum spin period of isolated NSs / magnetars dominated by an interaction between star's magnetic field and the disk. We find that the disk wind plays an important role in spin evolution, whose influence varies the power law index in the evolution equation of mass flow rate. For a magnetar without disk wind, the longest spin period is tens of hours. When the disk wind with a classical parameter is involved, the maximum spin period can reach hundreds of hours. But for a much extremely large index of mass flow rate due to disk wind or other angular momentum extraction processes, a spin period of $\sim$(16-160) days is still possible., Comment: Accepted for publication in ApJ

Binary millisecond pulsars (MSPs) are believed to have descended from low-mass X-ray binaries (LMXBs), which have experienced substantial mass transfer and tidal circularization. Therefore, they should have very circular orbits. However, the discovery of several eccentric binary MSPs (with eccentricity $e\sim 0.01-0.1$) challenges this standard picture. Three models have been proposed thus far based on accretion-induced collapse of massive white dwarfs (WDs), neutron star-strange star transition, and formation of circumbinary disks. All of them are subject to various uncertainties, and are not entirely consistent with observations. Here we propose an alternative model taking into account the influence of thermonuclear flashes on proto-WDs. We assume that the flashes lead to asymmetrical mass ejection, which imparts a mild kick on the proto-WDs. By simulating orbital changes of binary MSPs with multiple shell flashes, we show that it is possible to reproduce the observed eccentricities, provided that the kick velocities are around a few kms$^{-1}$., Comment: 13 pages, 6 figures, 1 table, accepted for publication in ApJ

Myosin-5a contains two heavy chains, which are dimerized via the coiled-coil regions. Thus, myosin-5a comprises two heads and two globular tail domains (GTDs). The GTD is the inhibitory domain that binds to the head and inhibits its motor function. Although the two-headed structure is essential for the processive movement of myosin-5a along actin filaments, little is known about the role of GTD dimerization. Here, we investigated the effect of GTD dimerization on its inhibitory activity. We found that the potent inhibitory activity of the GTD is dependent on its dimerization by the preceding coiled-coil regions, indicating synergistic interactions between the two GTDs and the two heads of myosin-5a. Moreover, we found that alanine mutations of the two conserved basic residues at N-terminal extension of the GTD not only weaken the inhibitory activity of the GTD but also enhance the activation of myosin-5a by its cargo-binding protein melanophilin (Mlph). These results are consistent with the GTD forming a head to head dimer, in which the N-terminal extension of the GTD interacts with the Mlph-binding site in the counterpart GTD. The Mlph-binding site at the GTD-GTD interface must be exposed prior to the binding of Mlph. We therefore propose that the inhibited Myo5a is equilibrated between the folded state, in which the Mlph-binding site is buried, and the preactivated state, in which the Mlph-binding site is exposed, and that Mlph is able to bind to the Myo5a in preactivated state and activates its motor function.

Through China's major cities such as Beijing, Shanghai, Nanjing, Xi'an, Changzhou and other public transport of passengers riding the escalator traffic characteristics of the data field acquisition, processing and analysis, summed up the escalator at the entrance and the middle section and passenger traffic characteristics capacity, established the escalator traffic density corresponding graph density and velocity graphs. According to the above conclusion, this paper presents the design choices of application notes, study for public transport type escalator classification, management and peak evacuation design provides a theoretical basis.

The survival rate of the recombinant Trichinella 53-kDa protein infected by the cecal ligation and puncture (CLP) model of sepsis in rats and the expression difference of macrophages were analyzed. Eighteen clean SD rats were selected for the present study. The rats were divided into the sham operation (n=5), control (n=5) and experimental (n=8) groups. The rats in the sham operation group underwent cecum division and suture with routine therapy for cure. The rats in the control and experimental groups were placed in the CLP model of sepsis in rats. The experimental group was administered recombinant Trichinella 53-kDa protein in advance, and the control group was administered the same dose of placebo. The survival rate of the rats within 6 and 12 h, the macrophage expression ratio, and the differences of the expression levels Th1-type cytokines IFN-γ and tumor necrosis factor (TNF)-α, and the Th2 type cytokines interleukin-4 (IL-4) and IL-13 were analyzed. The survival rate of rats in the experimental group was higher than that of the control group with a statistically significant difference (P

The present study investigates curcumin effect against sepsis-induced chronic lung injury (CLI) of male albino rats. Rats were grouped into four groups such rats undergoing a sham cecal ligature puncture (CLP), rats undergoing CLP, rats undergoing CLP and treated with saline and rats undergoing CLP and treated with curcumin (100 mg/kg bwt). After 45 days of treatment, bronchoalveolar fluid (BALF), blood and lung tissues were collected from the each animal. The total protein content, wet and dry (W/D) weight of lung tissues and some inflammatory cells in the BALF were measured. Histopathological analysis was carried out to investigate the alteration of the cellular architecture of lung tissues. Lipid peroxidation malondialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were determined. Cytokines such as interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-a) and macrophage inhibitory factor (MIF) were measured in the BALF. Curcumin administration significantly reduced CLP-induced inflammation and pulmonary edema. Curcumin treatment is significantly reduced MPO activity, and inflammatory cell accumulation in the BALF and also protein level, MDA, SOD, and W/D ratio were significantly reduced in the lung tissues. Also, curcumin reduced the expression of IL-A, TNF-a and MIF levels in the lung tissues. Histopathological study revealed the significant reduction of CLP-induced CLI in the curcumin-treated male albino rats. Taking all these data together, it is concluded that curcumin can act as a suitable therapeutic agent against CLP-induced CLI of male albino rats.

In this paper, we prove Hamilton’s Harnack inequality and the gradient estimates of the logarithmic heat kernel for the Witten Laplacian on complete Riemannian manifolds. As applications, we prove the W-entropy formula for the Witten Laplacian on complete Riemannian manifolds, and prove a family of logarithmic Sobolev inequalities on complete Riemannian manifolds with natural geometric condition.

A series of NbC/FeCrNiCu high entropy alloy matrix composites (2.5, 5, 7.5 and 10 vol% of NbC) were prepared by vacuum induction melting. The microstructures and mechanical properties of the composites were investigated using X-ray electron diffraction, scanning electron microscopy, transmission electron microscopy, tensile and hardness tests. The results show that the FeCrNiCu high entropy alloy matrix composites are composed of FCC solid solution embedded with NbC particles. A coherent relationship was identified between the alloy matrix and reinforcement phase. The formation of NbC particles increases the hardness from 337.6 HV to 591.3 HV. Moreover, compared with the base alloy, the tensile yield strength, ultimate tensile strength and ductility of the new composite first increases and then decreases with the increase of NbC content. The tensile yield strength, ultimate tensile strength and ductility reaches maximum for the composites containing 5 vol% of NbC, which is 458.2 MPa, 691.6 MPa and 24.7%, respectively. The strengthening mechanisms of the composites are discussed and the contributions of dislocation strengthening, load bearing effect and Orowan mechanism are quantified.

Several X-ray binaries (XRBs) have been identified to be associated with supernova remnants (SNRs). Because of the short lifetimes of SNRs, this leaves them to be the youngest known XRBs. This small group of binaries provides valuable information on the formation of compact stars under the framework of massive binary evolution. In this paper we review the observational characteristics of these youngest XRBs and discuss their possible implications on the initial conditions of compact stars and their interaction with the companion stars.

We present a systematic study of the X-ray binaries (XRBs) containing a black hole (BH) and a non-degenerate companion, in which mass transfer takes place via either capturing the companion's wind or Roche lobe overflow (RLO). As shown in our previous work that focusing on the formation and evolution of detached BH binaries, our assumed models relevant to BH's progenitors predicted significantly different binary properties \citep{sl19}. In this paper, we further follow the evolutionary paths of the BH systems that appearing as XRBs. By use of both binary population synthesis and detailed binary evolution calculations, we can obtain the potential population of BH XRBs. Distributions at the current epoch of various binary parameters have been computed. The observed sample of wind-fed XRBs can be well reproduced under assumption of all our models. The wind-fed XRBs are expected to be so rare ($ \lesssim 100 $) that only a couple of such systems have been detected. Comparison of known RLO XRBs with the calculated distributions of various binary parameters indicates that only the models assuming relatively small masses for BH progenitors can roughly match the observations. Accordingly we estimate that there are hundreds of RLO XRBs in the Milky Way, of which the majority are low-mass XRBs. The RLO systems may become ultraluminous X-ray sources (ULXs) if the BH accretes at a very high rate, we expect that about a dozen ULXs with a BH accretor may exist in a Milky Way$-$like galaxy., Comment: 17 pages, 15 figures, 2 tables, accepted by ApJ