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101. Nontoxic gemini cationic biodegradable polyurethane drug carriers: Synthesis, self-assembly and in vitro cytotoxicity

Author

Hong Tan, Xueling He, Lijuan Zhou, Mingming Ding, Qiang Fu, Xiaoting Fu, and Jiehua Li

Subjects
Light, Paclitaxel, Cell Survival, Chemistry, Pharmaceutical, Drug Compounding, Polyesters, Polyurethanes, In vitro cytotoxicity, Pharmaceutical Science, Carcinoma, Lewis Lung, Mice, Microscopy, Electron, Transmission, Cell Line, Tumor, Animals, Scattering, Radiation, Technology, Pharmaceutical, Particle Size, Micelles, Drug Carriers, Dose-Response Relationship, Drug, Chemistry, Cationic polymerization, Antineoplastic Agents, Phytogenic, Combinatorial chemistry, Kinetics, Spectrometry, Fluorescence, Solubility, Biodegradable polyurethane, Self-assembly, Drug carrier
Published
2011
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102. Purification and characterization of α2-macroglobulin from chum salmon plasma

Author

Hong Lin, Delin Duan, Pengfei Fu, and Xiaoting Fu

Subjects
chemistry.chemical_compound, Papain, Chromatography, chemistry, Ion exchange, Yield (chemistry), Size-exclusion chromatography, medicine, Polyethylene glycol, Trypsin, α 2 macroglobulin, medicine.drug, Macroglobulin
Abstract

Chum salmon plasma α 2 -macroglobulin (α 2 -M) was first puriαed by polyethylene glycol gradient precipitation, gel filtration and anion-exchange chromatography from chum salmon plasma. The α 2 -M was purified 47.77-fold with a yield of 28.90% towards papain. The α 2 -M showed molecualr weight (Mw) of 175 kDa and consists of two different subunits of Mw 95 kDa and 80 kDa, respectively. The α 2 -M was stable towards papain and trypsin at pH ranges from 5.0 to 8.0, and was thermal stable at temperatures below 50°C. The α 2 -M was applied to Alaska pollock surimi and was able to inhibit the gel weakening in a concentration-dependent manner.

Published
2011
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103. Spatial Data Model for Visualization System of GIS Based Urban Pipe Network

Author

Xiaoting Fu, Hao Lin, Juan Yang, Yupeng Xiao, and Liutong Xu

Subjects
Spatial data infrastructure, Geographic information system, Computer science, business.industry, Spatial network analysis software, computer.software_genre, Visualization, Data modeling, Metadata, Data visualization, Data mining, business, Spatial analysis, computer
Abstract

Since planar graphics can not meet the needs of precisely reflecting real spatial relationship between pipelines, it is necessary to build a 3D visualization system of urban pipe network. 3D spatial data model is the basis of data representation and spatial visualization. Based on the analysis of the features of urban pipe network and the requirements of the 3D model, a spatial data model for Urban Pipe Network Visualization System (UPNVS) is designed and organized by spatial metadata. The advantage of the spatial metadata is discussed in the paper. The application of the model in a real project shows that it is effective.

Published
2009
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104. Thematic Maps Service for GIS Based Urban Pipe Network Visualization System

Author

Hao Lin, Juan Yang, Xiaoting Fu, Yupeng Xiao, and Liutong Xu

Subjects
Service (systems architecture), Information retrieval, Geographic information system, business.industry, Computer science, computer.software_genre, Visualization, Upload, Data visualization, Thematic map, Graph drawing, Data as a service, Data mining, business, computer
Abstract

Urban pipe network pipelines are criss-crossing and have 3D (three-dimension) distribution. Plenty of attribute information and spatial data are involved. In order to display it in a more intuitive way, UPNVS (urban pipe network visualization system) is designed. The Thematic Maps service is a part of it. In this paper, we propose the Thematic Maps service, upload and edit data service, information attention service and 3D viewing service. While 3D display service concentrates on displaying simple map and unique value map. It implements the transit from 2D thematic maps to 3D and reflects the different property values of pipelines with different colors. This application enhances Thematic Maps service lively and visibility. Finally, we plug it to our UPNVS which can show the patterns and trends easily and provide the information for decision-making. At the same time, the results can also be applied to other visualization system and 3D thematic maps.

Published
2009
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105. A Service Stack for 3D Visualization of GIS Based Urban Pipe Network

Author

Ding Xiao, Xiaoting Fu, Hao Lin, Juan Yang, Liutong Xu, and Yupeng Xiao

Subjects
Geographic information system, Database, business.industry, Computer science, computer.software_genre, Visualization, Pipeline transport, Data visualization, Software, Scalability, Web service, business, computer, Reusability
Abstract

This paper studies the functional services of the 3D visualization of urban pipe network (UPN). In accordance with the characteristics of the UPN and its demands for 3D visualization. The division of the visualization services of the 3D visualization of UPN is researched, then a structure of services division named Service Stack is propose in this paper, which is applicable to the 3D visualization of UPN. The service stack provides a unified standard for the development of the 3D visualization of UPN, simplifies the process of the system development, and provides the system with good compatibility, scalability and reusability. Key technologies about the Service Stack are also discussed in this paper. Finally, based on the Service Stack, a prototype of Urban Pipe Network 3D visualization system is implemented.

Published
2009
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106. Purification and characterization of a novel beta-agarase, AgaA34, from Agarivorans albus YKW-34

Author

Xiaoting Fu, Sang Moo Kim, and Hong Lin

Subjects
DNA, Bacterial, Magnetic Resonance Spectroscopy, Glycoside Hydrolases, Size-exclusion chromatography, Gastropoda, Molecular Sequence Data, Enzyme Activators, Oligosaccharides, Disaccharides, Applied Microbiology and Biotechnology, Dithiothreitol, chemistry.chemical_compound, Hydrolysis, Sequence Analysis, Protein, Enzyme Stability, Animals, Urea, Glycoside hydrolase, Sodium dodecyl sulfate, Enzyme Inhibitors, Mercaptoethanol, Chromatography, biology, Molecular mass, Sequence Homology, Amino Acid, Alteromonadaceae, Sepharose, Agarase, Temperature, Sodium Dodecyl Sulfate, Galactosides, General Medicine, Sequence Analysis, DNA, Hydrogen-Ion Concentration, Chromatography, Ion Exchange, Molecular Weight, Kinetics, chemistry, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, biology.protein, Chromatography, Gel, Agarose, Biotechnology
Abstract

An extracellular beta-agarase (AgaA34) was purified from a newly isolated marine bacterium, Agarivorans albus YKW-34 from the gut of a turban shell. AgaA34 was purified to homogeneity by ion exchange and gel filtration chromatographies with a recovery of 30% and a fold of ten. AgaA34 was composed of a single polypeptide chain with the molecular mass of 50 kDa. N-terminal amino acid sequencing revealed a sequence of ASLVTSFEEA, which exhibited a high similarity (90%) with those of agarases from glycoside hydrolase family 50. The pH and temperature optima of AgaA34 were pH 8.0 and 40 degrees C, respectively. It was stable over pH 6.0-11.0 and at temperature up to 50 degrees C. Hydrolysis of agarose by AgaA34 produced neoagarobiose (75 mol%) and neoagarotetraose (25 mol%), whose structures were identified by matrix-assisted laser desorption ionization time-of-flight mass spectroscopy and (13)C NMR. AgaA34 cleaved both neoagarohexaose and neoagarotetraose into neoagarobiose. The k (cat)/K (m) values for hydrolysis agarose and neoagarotetraose were 4.04 x 10(3) and 8.1 x 10(2) s(-1) M(-1), respectively. AgaA34 was resistant to denaturing reagents (sodium dodecyl sulfate and urea). Metal ions were not required for its activity, while reducing reagents (beta-Me and dithiothreitol, DTT) increased its activity by 30%.

Published
2007

107. Antiangiogenic properties of caudatin in vitro and in vivo by suppression of VEGF-VEGFR2-AKT/FAK signal axis.

Author

XINZHI WANG, XIAOTING FU, SHIJUN ZHAO, XIAOYAN FU, HUIFANG ZHANG, LURONG SHAO, GANG LI, and CUNDONG FAN

Subjects
*NEOVASCULARIZATION inhibitors, *TUMOR growth, *GENE silencing, *CANCER cells, *CELL proliferation
Abstract

Tumor angiogenesis provides essential nutrients and oxygen to the tumor microenvironment, which is important in tumor growth, progression and metastasis. Inhibition of tumor angiogenesis represents one of the most promising strategies in tumor therapy. The authors previously demonstrated that caudatin, one species of C-21 steroidal from Cynanchum auriculatum (C. auriculatum), effectively inhibits human glioma growth in vitro and in vivo through triggering cell cycle arrest and apoptosis. However, little information regarding the antiangiogenic properties of caudatin in human glioma is available. Based on the author's previous study, the antiangiogenic effect of caudatin against human glioma was explored, and the underlying mechanism was investigated. The results suggested that caudatin treatment significantly inhibited HUVEC human umbilical vein endothelial cell proliferation, blocked the HUVECs migration, invasion and capillary-like tube formation by disturbing the vascular endothelial growth factor (VEGF)-VEGFR2-protein kinase B (AKT)/focal adhesion kinase (FAK) signal axis. Notably, caudatin treatment abolished the glioma cell growth by suppression of the in vivo angiogenesis, which involved FAK and AKT dephosphorylation and inhibition of VEGF expression. The findings validated the antiangiogenic potential of caudatin in hunting human glioma. [ABSTRACT FROM AUTHOR]

Published
2017
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108. Biodegradable gemini multiblock poly(ε-caprolactone urethane)s toward controllable micellization

Author

Hong Tan, Xiaoting Fu, Jiehua Li, Mingming Ding, Qiang Fu, and Lijuan Zhou

Subjects
chemistry.chemical_compound, Chemistry, PEG ratio, Polymer chemistry, technology, industry, and agriculture, Cationic polymerization, Zeta potential, Ammonium, macromolecular substances, General Chemistry, Gene delivery, Condensed Matter Physics, Caprolactone
Abstract

Unique self-assembly behavior of novel nontoxic gemini cationic biodegradable multiblock poly(e-caprolactone urethane)s which contain both gemini quaternary ammonium and PEG groups is firstly reported. The micellar size, size distributions, zeta potential, CMC and Kv could be well-tailored for application in drug and gene delivery.

Published
2010
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109. Lithium evolution in metal-poor stars: from pre-main sequence to the Spite plateau.

Author

Xiaoting Fu, Bressan, Alessandro, Molaro, Paolo, and Marigo, Paola

Subjects
*STELLAR evolution, *BIG bang theory, *NUCLEOSYNTHESIS, *ACCRETION (Astrophysics), *STELLAR atmospheres
Abstract

Lithium abundance derived in metal-poor main-sequence (MS) stars is about three times lower than the value of primordial Li predicted by the standard big bang nucleosynthesis when the baryon density is taken from the cosmic microwave background or the deuterium measurements. This disagreement is generally referred as the lithium problem. We here reconsider the stellar Li evolution from the pre-main sequence (PMS) to the end of the MS phase by introducing the effects of convective overshooting (OV) and residual mass accretion. We show that 7Li could be significantly depleted by convective OV in the PMS phase and then partially restored in the stellar atmosphere by a tail of matter accretion which follows the Li-depletion phase and that could be regulated by EUV photoevaporation. By considering the conventional nuclear burning and microscopic diffusion along the MS, we can reproduce the Spite plateau for stars with initial mass m0 = 0.62-0.80 M⊙, and the Li declining branch for lower mass dwarfs, e.g. m0 = 0.57-0.60 M⊙, for a wide range of metallicities (Z = 0.00001 to Z = 0.0005), starting from an initial Li abundance A(Li) = 2.72. This environmental Li evolution model also offers the possibility to interpret the decrease of Li abundance in extremely metal-poor stars, the Li disparities in spectroscopic binaries and the low Li abundance in planet hosting stars. [ABSTRACT FROM AUTHOR]

Published
2015
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110. FRACTIONATED CRYSTALLIZATION OF HDPE IN PS/POE/HDPE/SBS BLENDS

Author

Qiang Fu, Mingming Ding, Jing Cao, Xiaoting Fu, Changyue Yang, and Qin Zhang

Subjects
Toughness, Materials science, Polymers and Plastics, General Chemical Engineering, Organic Chemistry, technology, industry, and agriculture, law.invention, Differential scanning calorimetry, Brittleness, law, Phase (matter), Ultimate tensile strength, High-density polyethylene, Crystallization, Composite material, Dispersion (chemistry)
Abstract

The fractionated crystallization behavior of the minor dispersed HDPE phase in PS/POE/HDPE/SBS quaternary blends was investigated by differential scanning calorimetry (DSC). Interestingly, we found that the fractionated crystallization behavior of HDPE was molecular weight dependent. At a fixed composition, HDPE with lower molecular weight showed more obvious fractionated crystallization behavior than HDPE with higher molecular weight. This was ascribed to a finer dispersion of HDPE with lower molecular weight, as evidenced by SEM observations. The fractionated crystallization behavior of HDPE in the blends became less obvious with increasing of its content, due to a change of phase morphology from droplet to co-continuous structure. Correspondingly, a change of tensile toughness of the blends from brittle to ductile mode was observed.

Published
2008
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116. Theia: Faint objects in motion or the new astrometry frontier

Author

Boehm, Céline, Krone-Martins, Alberto, Amorim, António, Anglada-Escudé, Guillem, Brandeker, Alexis, Courbin, Frederic, Enßlin, Torsten, Falcão, António, Freese, Katherine, Holl, Berry, Labadie, Lucas, Leger, Alain, Malbet, Fabien, Mamon, Gary, Mcarthur, Barbara, Mora, Alcione, Shao, Michael, Sozzetti, Alessandro, Spolyar, Douglas, Villaver, Eva, Albertus, Conrado, Bertone, Stefano, Bouy, Hervé, Boylan-Kolchin, Michael, Brown, Anthony, Brown, Warren, Cardoso, Vitor, Chemin, Laurent, Claudi, Riccardo, Correia, Alexandre C. M., Crosta, Mariateresa, Crouzier, Antoine, Cyr-Racine, Francis-Yan, Damasso, Mario, Da Silva, António, Davies, Melvyn, Das, Payel, Dayal, Pratika, Val-Borro, Miguel, Diaferio, Antonaldo, Erickcek, Adrienne, Fairbairn, Malcolm, Fortin, Morgane, Fridlund, Malcolm, Garcia, Paulo, Gnedin, Oleg, Goobar, Ariel, Gordo, Paulo, Goullioud, Renaud, Hambly, Nigel, Hara, Nathan, Hobbs, David, Hog, Erik, Holland, Andrew, Ibata, Rodrigo, Jordi, Carme, Klioner, Sergei, Kopeikin, Sergei, Lacroix, Thomas, Laskar, Jacques, Le Poncin-Lafitte, Christophe, Luri, Xavier, Majumdar, Subhabrata, Makarov, Valeri, Massey, Richard, Mennesson, Bertrand, Michalik, Daniel, Almeida, André Moitinho, Mourão, Ana, Moustakas, Leonidas, Murray, Neil, Muterspaugh, Matthew, Oertel, Micaela, Ostorero, Luisa, Perez-Garcia, Angeles, Platais, Imants, I Portell I Mora, Jord, Quirrenbach, Andreas, Randall, Lisa, Read, Justin, Regos, Eniko, Rory, Barnes, Rybicki, Krzysztof, Scott, Pat, Schneider, Jean, Jakub Scholtz, Siebert, Arnaud, Tereno, Ismael, Tomsick, John, Traub, Wesley, Valluri, Monica, Walker, Matt, Walton, Nicholas, Watkins, Laura, White, Glenn, Evans, Dafydd Wyn, Wyrzykowski, Lukasz, Wyse, Rosemary, Abbas, Ummi, Alimi, Jean-Michel, Altmann, Martin, Alves, João, Anderson, Richard, Arenou, Frédéric, Bailer-Jones, Coryn, Carlton, Baugh, Biermann, Michael, Blanco-Cuaresma, Sergi, Bonomo, Aldo Stefano, Broderick, Avery, Busso, Giorgia, Cabrera, Juan, Carrasco, Josep Manel, Carvalho, Carla Sofia, Castellani, Marco, Cermeño-Gavilán, Marina, Chadwick, Paula, Darling, Jeremy, Davidson, Michael, Angeli, Francesca, Carvalho, Reinaldo, Desidera, Silvano, Done, Chris, Ducourant, Christine, Erkal, Denis, Eyer, Laurent, Famey, Benoit, Feltzing, Sofia, Garcia, Emilio Fraile, Gomez, Facundo Ariel, Frenk, Carlos, Gai, Mario, Galli, Phillip, Galluccio, Laurent, Gavras, Panagiotis, Giacobbe, Paolo, Gratton, Raffaele, Guglielmetti, Fabrizia, Gunther, Eike, Hall, David, Harrison, Diana, Hatzes, Artie, Hestroffer, Daniel, Ishida, Emille, Jablonka, Pascale, Jacobs, Christopher, Janson, Markus, Jasche, Jens, Jauzac, Mathilde, Jones, Hugh, Jonker, Peter, Julbe, Francesc, Kneib, Jean-Paul, Kordopatis, Georges, Lancon, Arianne, Lattanzi, Mario Gilberto, Leguidou, Jean-Michel, Lehnert, Matt, Lehto, Harry, Lopes, Ilidio, Maldonado, Jesus, Marconi, Marcella, Martin, Nicolas, Marie-Elisabeth, Maury, Mazumdar, Anupam, Michtchenko, Tatiana, Minardi, Stefano, Munoz, Carlos, Murante, Giuseppe, Musella, Ilaria, Gerhard, Ortwin, Pagano, Isabella, Pani, Paolo, Paetzold, Martin, Daniel, Pfenniger, Piotto, Giampaolo, Preis, Olivier, Produit, Nicolas, Prost, Jean-Pierre, Rauer, Heike, Raymond, Sean, Reinaldo, Rosa, Revaz, Yves, Rita, Ribeiro, Rimoldini, Lorenzo, Huguet, Arnau Rios, Ripepi, Vincenzo, Rocci, Pier-Francesco, Rodriguez Frias, Maria D., Rosa, Reinaldo R., Sahlmann, Johannes, Saltas, Ippocratis, E E Lemos, José Pizarro Sand, Sarro, Luis M., Schaefer, Bjoern Malte, Schewtschenko, Jascha, Segransan, Damien, Selsis, Franck, Silk, Joe, Silva, Manuel, Solitro, Filomena, Spagna, Alessandro, Springel, Volker, Süveges, Maria, Teixeira, Ramachrisna, Shindou, Tetsuo, Thebault, Philippe, Tian, Feng, Turon, Catherine, Valle, José W. F., Vasiliev, Eugene, Vladilo, Juan, Martin, Vollmann, Ward, Martin, Weller, Jochen, Wilkinson, Mark, Wolf, Sebastian, Xiaoting, Fu, Yamada, Yoshiyuki, Zschocke, Sven, Zucker, Shay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Université Grenoble Alpes (UGA), Institut d'Astrophysique de Paris (IAP), Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Institut de Mécanique Céleste et de Calcul des Ephémérides (IMCCE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg (UNISTRA), Observatoire de Paris - Site de Meudon (OBSPM), Observatoire de Paris, Laboratoire Univers et Théories (LUTH (UMR_8102)), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Galaxies, Etoiles, Physique, Instrumentation (GEPI), Laboratoire d'Astrophysique de Bordeaux [Pessac] (LAB), Université de Bordeaux (UB)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de la Côte d'Azur (OCA), Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Centre National d’Études Spatiales [Paris] (CNES), Joseph Louis LAGRANGE (LAGRANGE), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Theia, Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université de Lille-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, Centre National de la Recherche Scientifique (CNRS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), and HEP, INSPIRE

Subjects
[PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics::Space Physics, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics::Earth and Planetary Astrophysics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics::Galaxy Astrophysics
Abstract

In the context of the ESA M5 (medium mission) call we proposed a new satellite mission, Theia, based on relative astrometry and extreme precision to study the motion of very faint objects in the Universe. Theia is primarily designed to study the local dark matter properties, the existence of Earth-like exoplanets in our nearest star systems and the physics of compact objects. Furthermore, about 15 $\%$ of the mission time was dedicated to an open observatory for the wider community to propose complementary science cases. With its unique metrology system and "point and stare" strategy, Theia's precision would have reached the sub micro-arcsecond level. This is about 1000 times better than ESA/Gaia's accuracy for the brightest objects and represents a factor 10-30 improvement for the faintest stars (depending on the exact observational program). In the version submitted to ESA, we proposed an optical (350-1000nm) on-axis TMA telescope. Due to ESA Technology readiness level, the camera's focal plane would have been made of CCD detectors but we anticipated an upgrade with CMOS detectors. Photometric measurements would have been performed during slew time and stabilisation phases needed for reaching the required astrometric precision., Comment: http://theia.phyip3.dur.ac.uk

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