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The performance of ultrasonic transducers is largely determined by the piezoelectric properties and geometries of their active elements. Due to the brittle nature of piezoceramics, existing processing tools for piezoelectric elements only achieve simple geometries, including flat disks, cylinders, cubes and rings. While advances in additive manufacturing give rise to free-form fabrication of piezoceramics, the resultant transducers suffer from high porosity, weak piezoelectric responses, and limited geometrical flexibility. We introduce optimized piezoceramic printing and processing strategies to produce highly responsive piezoelectric microtransducers that operate at ultrasonic frequencies. The 3D printed dense piezoelectric elements achieve high piezoelectric coefficients and complex architectures. The resulting piezoelectric charge constant, d33, and coupling factor, kt, of the 3D printed piezoceramic reach 583 pC/N and 0.57, approaching the properties of pristine ceramics. The integrated printing of transducer packaging materials and 3D printed piezoceramics with microarchitectures create opportunities for miniaturized piezoelectric ultrasound transducers capable of acoustic focusing and localized cavitation within millimeter-sized channels, leading to miniaturized ultrasonic devices that enable a wide range of biomedical applications.

The prevalence of uncontrolled hypertension is high and increasing in low-income and middle-income countries. We tested the effectiveness of a multifaceted intervention for blood pressure control in rural China led by village doctors (community health workers on the front line of primary health care).In this open, cluster randomised trial (China Rural Hypertension Control Project), 326 villages that had a regular village doctor and participated in the China New Rural Cooperative Medical Scheme were randomly assigned (1:1) to either village doctor-led multifaceted intervention or enhanced usual care (control), with stratification by provinces, counties, and townships. We recruited individuals aged 40 years or older with an untreated blood pressure of 140/90 mm Hg or higher (≥130/80 mm Hg among those with a history of cardiovascular disease, diabetes, or chronic kidney disease) or a treated blood pressure of 130/80 mm Hg or higher. In the intervention group, trained village doctors initiated and titrated antihypertensive medications according to a standard protocol with supervision from primary care physicians. Village doctors also conducted health coaching on home blood pressure monitoring, lifestyle changes, and medication adherence. The primary outcome (reported here) was the proportion of patients with a blood pressure of less than 130/80 mm Hg at 18 months. The analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, NCT03527719, and is ongoing.Between May 8 and November 28, 2018, we enrolled 33 995 individuals from 163 intervention and 163 control villages. At 18 months, 8865 (57·0%) of 15 414 patients in the intervention group and 2895 (19·9%) of 14 500 patients in the control group had a blood pressure of less than 130/80 mm Hg, with a group difference of 37·0% (95% CI 34·9 to 39·1%; p0·0001). Mean systolic blood pressure decreased by -26·3 mm Hg (95% CI -27·1 to -25·4) from baseline to 18 months in the intervention group and by -11·8 mm Hg (-12·6 to -11·0) in the control group, with a group difference of -14·5 mm Hg (95% CI -15·7 to -13·3 mm Hg; p0·0001). Mean diastolic blood pressure decreased by -14·6 mm Hg (-15·1 to -14·2) from baseline to 18 months in the intervention group and by -7·5 mm Hg (-7·9 to -7·2) in the control group, with a group difference of -7·1 mm Hg (-7·7 to -6·5 mm Hg; p0·0001). No treatment-related serious adverse events were reported in either group.Compared with enhanced usual care, village doctor-led intervention resulted in statistically significant improvements in blood pressure control among rural residents in China. This feasible, effective, and sustainable implementation strategy could be scaled up in rural China and other low-income and middle-income countries for hypertension control.Ministry of Science and Technology of China.

Funder: office of naval research global; doi: http://dx.doi.org/10.13039/100007297; Grant(s): N00014-18-1-2658, N00014-20-1-2504:P00001, The growth of additive manufacturing technologies has spurred interest in examining multi-material micro-architected materials for filling the so-called white spaces in the Ashby strength versus toughness plots. We investigate this problem using interconnected and interpenetrating double gyroids comprising ductile and brittle phases as an exemplar. Both strength and toughness at the initiation of crack growth are shown to vary non-monotonically with the volume fraction of the two phases and multi-material double gyroids significantly outperform their single material counterparts. However, we establish that at a given relative density, the strength and toughness cannot be simultaneously enhanced for architecture designs, which include varying gyroid orientations, phase volume fractions, and the unit cell length scales of the two phases. Intriguingly, even crack flank bridging by the ductile phase during crack growth is insufficient to overcome this inherent property of the interpenetrating gyroids. Our conclusion is that multi-material interpenetrating micro-architected solids are unlikely to outperform single material non-interpenetrating lattices from a strength–toughness perspective but rather become optimal when multi-functionality is required. Impact statement The integration of materials and architectural features at multiple scales into structural mechanics gave us structural designs such as the Eiffel Tower. The explosion of additive manufacturing methods has opened new avenues for the invention of multi-material micro-architected materials that simultaneously possess high strength and toughness at a low density, and thereby can fill the so-called “white spaces” in the Ashby strength–toughness space. The idea is to construct three-dimensional materials with a network of crack arrestors like in rip-stop nylon and break the link between toughness and strength. We use interconnected and interpenetrating double gyroids comprising ductile and brittle phases as an exemplar to investigate the opportunities of such designs. Intriguingly, from a perspective based solely on strength and toughness, we show that multi-material micro-architectures cannot outperform their single material counterparts at a given relative density. In fact, in most designs the coupling between the two phases is non-synergistic. Rather, we argue that multi-material designs such as those used in rip-stop nylon are driven by multi-functional considerations beyond mechanical properties. Graphical abstract

TC21 titanium alloy, as an important metal to fabricate the aircraft structural components, has attracted great attentions recently. A TC21 titanium alloy with widmanstatten structure was isothermally compressed. Based on the microstructure observation, the evolution of initial β grain, Grain Boundary α phase (αGB), lamellar α and interlayered β was systematically investigated. The results showed that, with the increasing of height reduction, the αGB underwent an evolution process from bending/kinking to breaking inducing the corresponding blurring of initial coarse β grain outline. Meanwhile, a significant phase transformation from α to β took place at the terminations of broken αGB. The evolution of lamellar α and interlayered β in the colony was closely related to their deformation compatibility. In the α colony, the interlayered β experienced a larger deformation amount than lamellar α. The higher distortion energy promoted the occurrence of Dynamic Recovery (DRV) and Dynamic Recrystallization (DRX) to generate many Low Angle Boundaries (LABs) and High Angle Boundaries (HABs) in interlayered β, which induced an apparent grain refinement of β phase. On the contrary, the lower distortion energy and low deformation temperature suppressed the occurrence of DRV/DRX and restrained the globularization of lamellar α. Furthermore, the microstructure observation clearly revealed that the shearing separation mechanism dominated the evolution of the α phase from lamellar to short bar-like morphology.

In a previously published study we reported that sow dietary leucine supplementation during late pregnancy significantly improved newborn piglet birth weight by stimulating protein synthesis in the longissimus dorsi muscle.

The last two decades have seen enormous gains in industrial adoption of additive manufacturing (AM) technologies. Its layer-wise approach to fabrication offers designers the opportunity to create structures with unique performance advantages over their traditionally manufactured counterparts, and have created new manufacturing business models and supply chains. While today’s AM technologies have enabled the creation of new geometries, future AM systems that offer simultaneous processing of multiple materials in a single build open opportunities for new product functionality that cannot be achieved by traditional manufacturing methods. Advances in multi-material additive manufacturing, which integrate dissimilar material into a complex, three-dimensional object, is emerging but the advances have been sporadic. Moving beyond homogenous materials, adding multi-materials, gradient, functional and responsive materials, and materials with heterogeneous and graded properties means that a single additive process based on either energy delivery or material deposition alone may not be suitable. This perspective gives a brief overview of the current status, challenges, and future recommendations for multi-material additive manufacturing. The authors aim to expand the notion of multi-material additive manufacturing beyond combining materials with dissimilar properties, to combinations of materials at different length scales, material classes as well as multiple functionalities.

Surgical removal of the tumor is currently the first-line treatment for lung cancer, but the procedure may accelerate cancer progression through immunosuppression. However, whether CCL2 (C-C motif chemokine ligand 2) enhances cancer progression by affecting regulatory T cells (Tregs) remains unknown. We found that the volume and weight of tumors were larger in the surgical trauma group than in the control group. CCL2 expression and Treg abundance were increased in tumor tissues after surgical trauma, and CCL2 expression was positively associated with Treg abundance. These results demonstrated that surgical trauma contributes to lung cancer progression by increasing CCL2 expression, thus promoting Treg recruitment.

In recent years, accelerative aging society is meeting the short supply of young and middle-aged labor. Particularly, most young people are reluctant to work in the construction industry, which has caused the labor cost of floor tiling to rise year by year. In addition, floor tiling requires workers to continuously bend over or lean over to work, which greatly jeopardizes the physical health of them. Therefore, advanced technology applied in floor tiling is highly demanded to replace the traditional manual method. On the context, the automatic method of floor tiling may promote the transformation and upgrading of the industry. Although a few robots for floor tiling have been developed, the automation of existing systems is still at a low level. This paper proposes a robot floor-tiling control strategy based on visual measurement feedback and finite-state machine, in which the calculation of tile position information in limited field of vision is obtained by an improved Canny edge detection and a Hough linear transformation. Moreover, an algorithm for complementing tile position information based on visual measurement is proposed, and the quality of tile laying is evaluated online. To evaluate the effect of the proposed control strategy, the experimental verifications are given. The experimental results indicate that the proposed method can complete the automatic floor tiling with high accuracy.

Sterol regulatory element-binding proteins (SREBPs) play vital roles in fatty acid metabolism and other metabolic processes in mammals. However, in penaeid shrimp, the repertoire of genes modulated by SREBP is unknown. Here, RNA interference-mediated knockdown followed by transcriptome sequencing on the Illumina Novaseq 6000 platform was used to explore the genes modulated by SREBP in Penaeus vannamei hepatopancreas. A total of 706 differentially expressed genes (DEGs) were identified, out of which 282 were upregulated and 424 downregulated. Although gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that most of the downregulated DEGs were involved in physiological processes related to immunity, metabolism, and cellular signaling pathways, many of the dysregulated genes have uncharacterized functions. While most of the dysregulated genes were annotated in metabolic processes, such as carbohydrate metabolism, lipid metabolism, signal transduction, and immune system, a large number (42.21%) are uncharacterized. Collectively, our current data revealed that SREBP modulates many genes involved in crucial physiological processes, such as energy metabolism, immune response, and cellular signaling pathways, as well as numerous genes with unannotated functions, in penaeid shrimp. These findings indicated that our knowledge of the repertoire of genes modulated by SREBP in shrimp lags behind that of mammals, probably due to limited research or because the complete genome of P. vannamei has just been sequenced.

The development of liver fibrosis is associated with inflammatory responses resulting from chronic liver disease. Immature dendritic cells (imDCs) play an important role in modulating the inflammatory environment of the liver. This study investigated the effects of imDCs on the regulation of hepatic stellate cells (HSCs) during liver fibrosis. We isolated and induced imDCs from monocytes of healthy volunteers, activated LX-2 cells with TGF-β to establish in vivo liver fibrosis HSCs model, and then set up a cell co-culture system with transwell membranes. imDC surface markers and apoptosis rates of LX-2 cells were detected by flow cytometry. The concentration of IL-10 secreted by imDC was measured through ELISA. The expression of α-SMA in LX-2 after co-culture was examined by qRT‑PCR. Proliferation of LX-2 cells were detected by CCK-8. The western blot was used to illustrate the LX-2 activation-related proteins such as Smad3/7 and TGF-β1. The imDCs co-culture group and the interleukin-10 (IL-10) treatment group had similar results, as they were both able to increase apoptosis, inhibit proliferation, downregulate α-SMA mRNA, and reduce TGF-β1 and Smad3 protein expression in LX-2 cells. Additionally, the Smad7 protein level was increased after treatment with imDC and IL-10. However, the results in the IL-10 antagonist group showed the opposite trend to that of imDCs and IL-10 groups. Thus, these results suggest that imDC secretion of IL-10 negatively regulates activated LX-2 cells, probably via inhibition of the TGF-β1/Smad3 pathway and increased expression of Smad7 protein. This may be a potential therapeutic target for liver fibrosis.

A portable sensor for visual monitoring of Fe

In this work, we study the equilibrium configurations in a nematic pi-cell under an electric field using the one-dimensional Oseen-Frank director model. The equilibrium orientational configurations that can be attained in a pi-cell are known as splay, bend, and twist. Among those, bend and twist are topologically equivalent and can be transitioned into one another as voltage varies. The transition can be continuous or abrupt depending on the material parameters. On the other hand, the splay configuration becomes asymmetric for sufficiently high voltages if the liquid crystal has a positive dielectric anisotropy. We determine those threshold voltages and characterize the order of transitions in terms of the elastic constants and the pretilt angle at the boundary.

Plate-based lattices are predicted to reach theoretical Hashin–Shtrikman and Suquet upper bounds on stiffness and strength. However, simultaneously attaining high energy absorption in these plate-lattices still remains elusive, which is critical for many structural applications such as shock wave absorber and protective devices. In this work, we present bi-material isotropic cubic + octet sandwich plate-lattices composed of carbon fiber-reinforced polymer (stiff) skins and elastomeric (soft) core. This bi-material configuration enhances their energy absorption capability while retaining stretching-dominated behavior. We investigate their mechanical properties through an analytical model and finite element simulations. Our results show that they achieve enhanced energy absorption approximately 2–2.8 times higher than their homogeneous counterparts while marginally compromising their stiffness and strength. When compared to previously reported materials, these materials achieve superior strength-energy absorption characteristics, making them an excellent candidate for stiff and strong, lightweight energy absorbing applications. Graphic Abstract: [Figure not available: see fulltext.] Published version

The bacterium Vibrio cholerae can colonize the human intestine and cause cholera, but spends much of its life cycle in seawater. The pathogen must adapt to substantial environmental changes when moving between seawater and the human intestine, including different availability of carbon sources such as fructose. Here, we use in vitro experiments as well as mouse intestinal colonization assays to study the mechanisms used by pandemic V. cholerae to adapt to these environmental changes. We show that a LacI-type regulator (FruI) and a fructose/H+ symporter (FruT) are important for fructose uptake at low fructose concentrations, as those found in seawater. FruT is downregulated by FruI, which is upregulated when O2 concentrations are low (as in the intestine) by ArcAB, a two-component system known to respond to changes in oxygen levels. As a result, the bacteria predominantly use FruT for fructose uptake under seawater conditions (low fructose, high O2), and use a known fructose phosphotransferase system (PTS, Fpr) for fructose uptake under conditions found in the intestine. PTS activity leads to reduced levels of intracellular cAMP, which in turn upregulate virulence genes. Our results indicate that the FruT/FruI system may be important for survival of pandemic V. cholerae in seawater.

We consider sinusoidal undulations which appear on certain garden hoses under normal use. We propose a model, using linear elasticity, explaining this phenomenon, and make a connection with biological structures as well as self-buckling. We compare observations with model predictions and suggest potential applications in the area of shape-changing materials.

To enhance the sensing performance of precious metal nanomaterials, porous Ag-chitosan nanospheres (AgNPs-cys-CS) were developed for the first time in this work. There was a strong coordination bon...

This article is the second in a four-part series of articles providing an overview of the challenges and opportunities in microscale additive manufacturing (AM) processes with applications in fabrication of high precision micro/nano-products. Laser-based microscale additive manufacturing processes are discussed this article. Compared to the other AM processes, laser-based processes provide several unique advantages, especially in terms of a wide variety of processable materials and high volumetric throughputs. The processes discussed in this paper can fabricate complex microscale features with minimum resolutions ranging from hundreds of nanometers to hundreds of microns. However, there are several fundamental limits and trade-offs which hinder the scalability of these processes. The paper discusses the limits to the materials, resolution, geometry, and volumetric throughput and proposes approaches to mitigate these limits and improve the scalability of laser-based microscale AM processes.

Microscale additive manufacturing is one of the fastest growing areas of research within the additive manufacturing community. However, there are still significant challenges that exist in terms of available materials, resolution, throughput, and ability to fabricate true three-dimensional geometries. These challenges render commercialization of currently available microscale additive manufacturing processes difficult. This paper is the last one in a four-part series of articles which review the current state-of-the-art of microscale additive manufacturing technologies and investigate the factors that currently limit each microscale additive manufacturing technology in terms of materials, resolution, throughput, and ability to fabricate complex geometries. Parts I, II and III offer prognoses about the future viability and applications of each technology along with suggested future research directions that could be used to bring each process technology in line with its fundamental, physics-based limitations. This paper brings together the general design guidelines that must be followed while designing scalable microscale AM processes. Finally, the paper concludes with an analysis of the role of precision engineering in the future advancement of microscale additive manufacturing technologies. This series of publications is a joint effort by the members and affiliates of the Micro-Nano Technical Leadership Committee of the American Society for Precision Engineering (ASPE).

Cholesteric liquid crystals are tunable self-assembled photonic bandgap materials. Because of their unusual properties and potential for applications in photonics, their optical properties have rec...

Invaginations are partial enclosures formed by surfaces. Typically formed by biological membranes; they abound in nature. In this paper, we consider fundamentally different structures: elastically stabilized invaginations. Focusing on spherical invaginations formed by elastic membranes, we carried out experiments and mathematical modeling to understand the stress and strain fields underlying stable structures. Friction plays a key role in stabilization, and consequently the required force balance is an inequality. Using a novel scheme, we were able to find stable solutions of the balance equations for different models of elasticity, with reasonable agreement with experiments., 10 pages, 5 figures

Taxis are an important component of the urban public transportation system, with wide geographical coverage and on-demand services characteristics. Thorough understanding of the built environment affecting taxi ridership can enable transportation authorities to develop targeted policies for transportation planning. Previous studies in this field had few data sources and did not consider the spatiotemporal variability. This study aims to develop an analytical framework for understanding the spatiotemporal correlation between the urban built environment and taxi ridership, which is empirically analyzed in New York City. The built environment is defined through multisource data in terms of density, design, diversity, and destination accessibility. Besides the exploration of travel patterns, the spatiotemporal heterogeneity of taxi ridership is modeled using geographically and temporally weighted regression (GTWR). The result shows that GTWR outperforms ordinary least squares (OLS), geographically weighted regression (GWR), and temporally weighted regression (TWR) in both goodness of fit and explanatory accuracy. More importantly, our study found that land use diversity is negatively correlated with taxi ridership, while transportation diversity is positively correlated with it. A highly accessible road network improves the people’s demand for taxis in the morning rush hours. Moreover, the density of railway stations is positively correlated with taxi ridership on weekdays but adversely on weekends. These findings provide practical insights for urban transportation policy development and taxicab regulation.

The determination of the mechanical properties of materials is important for the creation of physical models and describing mechanisms for converting diverse stimuli into mechanical response. It is...

At present, research on the influence of water on the physical properties of rocks is mostly focused on the macroscopic angle. Studies on nanoscale pore structure changes caused by water are few. Shale is characterized by good pore structure and high content of hydrophilic clay minerals susceptible to water. Based on this, in this paper the shale samples were obtained from underground layers 3000 m deep in Songliao Basin, Jilin Province, China. The sample parameters are measured by steam adsorption and nitrogen adsorption experiments under different soaking time conditions. The study shows that the pore structure of shale depends mainly on mineral composition and soaking time. With increase in soaking time, the amount of water vapor adsorption first decreases by 10% and then gradually increases. With water migration in the rock some pore structures are filled with shale particles. As the bubble time increases, the ion diffusion causes development of new pores and micro-cracks, and the adsorbed water vapor amount increases. At the microscopic scale, it is of great practical significance to study the nanoscale pore structure and adsorption characteristics of water vapor in the soft for different soaking time, and to further explore the stress characteristics, adsorption law, and gas migration in shale.

Water is one of the causes of softening of soft rocks in deep strata. Water absorption in soft rock with high clay content may cause strength softening and deformation. In this paper, soft rock samples from three deep strata are investigated, and the stratigraphic characteristics such as stratum physical parameters, mineral composition, and pore structure are systematically analyzed. The characteristics of water vapor adsorption curves of deep strata soft rock are obtained by water vapor adsorption experiments. The authors analyzed the main factors controlling water vapor adsorption capacity of the rock samples. The experimental results show that the water vapor adsorption capacity increases with increase in humidity. When the humidity exceeds 0.8, the adsorption of water vapor by soft rock increases rapidly. The adsorption capacity of shale is significantly higher than that of conglomerate samples, and the difference between coarse conglomerate and fine conglomerate samples is insignificant. It is shown that water vapor adsorption correlates positively with clay mineral content, particularly minerals with high specific surface area. Under low humidity the temperature has little effect on the adsorption of soft rock water vapor. As the humidity increases, a rise in temperature can significantly increase the water vapor adsorption capacity The results also show that the soft rock water vapor adsorption capacity correlates negatively with initial moisture content, porosity, and permeability. This study is of great significance for understanding the hydrological characteristics and catastrophic processes of deep strata soft rocks.

MIR396b had been cloned and overexpressed in Salvia miltiorrhiza hairy roots. MiR396b targets SmGRFs, SmHDT1, and SmMYB37/4 to regulate cell growth and secondary metabolism in S. miltiorrhiza hairy roots. Danshen (Salvia miltiorrhiza Bunge) is a valuable medicinal herb with two kinds of clinically used natural products, salvianolic acids and tanshinones. miR396 is a conserved microRNA and plays extensive roles in plants. However, it is still unclear how miR396 works in S. miltiorrhiza. In this study, an smi-MIR396b has been cloned from S. miltiorrhiza. Overexpression of miR396b in danshen hairy roots inhibited hairy root growth, reduced salvianolic acid concentration, but enhanced tanshinone accumulation, resulting in the biomass and total salvianolic acids respectively reduced to 55.5 and 72.1% of the control and total tanshinones increased up to 1.91-fold of the control. Applied degradome sequencing, 5′RLM-RACE, and qRT-PCR, 13 targets for miR396b were identified including seven conserved SmGRF1-7 and six novel ones. Comparative transcriptomics and microRNomics analysis together with qRT-PCR results confirmed that miR396b targets SmGRFs, SmHDT1, and SmMYB37/4 to mediate the phytohormone, especially gibberellin signaling pathways and consequentially resulted in the phenotype variation of miR396b-OE hairy roots. Furthermore, miR396b could be activated by methyl jasmonate, abscisic acid, gibberellin, salt, and drought stresses. The findings in this study indicated that smi-miR396b acts as an upstream and central regulator in cell growth and the biosynthesis of tanshinones and salvianolic acids, shedding light on the coordinated regulation of plant growth and biosynthesis of active ingredients in S. miltiorrhiza.

Background Propofol is a common sedative-hypnotic drug traditionally used for inducing and maintaining general anesthesia. Recent studies have drawn attention to the nonanesthetic effects of propofol, but the potential mechanism by which propofol suppresses non-small-cell lung cancer (NSCLC) progression has not been fully elucidated. Methods For the in vitro experiments, we used propofol (0, 2, 5, and 10 µg/mL) to treat A549 cells for 1, 4, and 12 hours and Cell Counting Kit-8 (CCK-8) to detect proliferation. Apoptosis was measured with flow cytometry. We also transfected A549 cells with an microribonucleic acid-21 (miR-21) mimic or negative control ribonucleic acid (RNA) duplex and phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) small interfering ribonucleic acid (siRNA) or negative control. PTEN, phosphorylated protein kinase B (pAKT), and protein kinase B (AKT) expression were detected using Western blotting, whereas miR-21 expression was examined by real-time polymerase chain reaction (RT-PCR). In vivo, nude mice were given injections of A549 cells to grow xenograft tumors; 8 days later, the mice were intraperitoneally injected with propofol (35 mg/kg) or soybean oil. Tumors were then collected from mice and analyzed by immunohistochemistry and Western blotting. Results Propofol inhibited growth (1 hour, P = .001; 4 hours, P ≤ .0001; 12 hours, P = .0004) and miR-21 expression (P ≤ .0001) and induced apoptosis (1 hour, P = .0022; 4 hours, P = .0005; 12 hours, P ≤ .0001) in A549 cells in a time and concentration-dependent manner. MiR-21 mimic and PTEN siRNA transfection antagonized the suppressive effects of propofol on A549 cells by decreasing PTEN protein expression (mean differences [MD] [95% confidence interval {CI}], -0.51 [-0.86 to 0.16], P = .0058; MD [95% CI], 0.81 [0.07-1.55], P = .0349, respectively), resulting in an increase in pAKT levels (MD [95% CI] = -0.82 [-1.46 to -0.18], P = .0133) following propofol exposure. In vivo, propofol treatment reduced NSCLC tumor growth (MD [95% CI] = -109.47 [-167.03 to -51.91], P ≤ .0001) and promoted apoptosis (MD [95% CI] = 38.53 [11.69-65.36], P = .0093). Conclusions Our study indicated that propofol inhibited A549 cell growth, accelerated apoptosis via the miR-21/PTEN/AKT pathway in vitro, suppressed NSCLC tumor cell growth, and promoted apoptosis in vivo. Our findings provide new implications for propofol in cancer therapy and indicate that propofol is extremely advantageous in surgical treatment.

BACKGROUND Chlorothalonil is a conventional chloroaromatic fungicide and is toxic to many aquatic species. This study was designed to investigate the effects of six flavonoids on the photolysis of chlorothalonil under sunlight and artificial light. RESULTS Flavonoids sensitized the photolysis of chlorothalonil under sunlight and artificial light by 6.7-18.3 and 2.4-7.5 times, respectively, in comparison with a flavonoid-free control. Photosensitization effect of each of the six flavonoids was greater under sunlight irradiation than under high-pressure mercury lamp irradiation. Cyanidin showed greater photosensitization effects than luteolin, galangin, quercetin, morin and kaempferol. Chlorothalonil underwent photo-reductive dechlorination and no hydrolysis product was formed in the presence of flavonoids. Hydroxyl and hydrogen radicals were detected in the absence and presence of cyanidin, respectively, under light irradiation. CONCLUSION The photosensitization effect of flavonoids on chlorothalonil photolysis is apparently related to flavonoid structure and might be due to their hydrogen donation capacity. These results highlight benefit of using flavonoids to manage aquatic pollution and reduce aquatic toxicity, and have great relevance in predicting the degradation kinetics and biological impacts of chlorothalonil in surface water. © 2020 Society of Chemical Industry.

Three-dimensional (3D) printing can create complex geometries that could be of use in the development of electronics. However, the approach is mainly limited to non-functional structural materials, and the 3D printing of electronic devices typically requires multiple process stages of embedding, spraying and writing. Here, we report a 3D printing approach that can volumetrically deposit multiple functional materials within arbitrary 3D layouts to create electronic devices in a single step. Our approach prints 3D structures with a programmable mosaic of distinct surface charge regions, creating a platform to deposit functional materials into complex architectures based on localized electrostatic attraction. The technique allows selective volumetric depositions of single metals and also diverse active material combinations, including ceramic, semiconducting, magnetic and colloidal materials, into site-specific 3D topologies. To illustrate the capabilities of our approach, we use it to fabricate devices with 3D electronic interfaces that can be used for tactile sensing, internal wave mapping and shape self-sensing. A 3D printing technique that produces structures with programmable patterns of charged surface, allowing different functional materials to be deposited in pre-defined regions, can be used to create electronic devices with a single printing step.

In the field of liquid crystals, it is well known that rodlike molecules interacting via long-range attractive interactions or short-range repulsive potentials can exhibit orientational order. In this work, we are interested in what would happen to systems of rodlike particles interacting via a long-range repulsive potential. In our model, each particle consists of a number of point dipoles uniformly distributed along the particle length, with all dipoles pointing along the z axis so that the rodlike particles repel each other when they lie in the x-y plane. Dipoles from different particles interact via an r^{-3} potential, where r is the distance between the dipoles. We have considered two model systems, each with N particles in a unit cell with periodic boundary conditions. In the first, particle centers are fixed on a square or triangular lattice but they are free to rotate. In the second, particles are free to translate as well as rotate in cells with variable shapes. Here they self-assemble to form configurations where the stress tensors are isotropic. Our numerical results show that, at low temperatures, the particles tend to form stripes with alternating orientations, resembling herringbone patterns or the anticlinic Sm-C_{A} liquid crystal phase.