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Regional sustainability and transportation sustainability have been intensely discussed and analyzed in recent decades. Though the use of indicators has been adopted in those models, debates continue on what indicators should be used and how to optimize the number of indicators. This results in the lack of a comprehensive and efficient method to assess and compare the sustainability of a sub-system, such as transportation system, and overall regional sustainability. A thorough literature review is conducted to identify indicators used to assess regional sustainability and transportation sustainability. Then, based on the available data, two sets of indicators for regional sustainability and transportation sustainability are identified and calculated respectively for the 382 metropolitan statistical areas (MSAs) in the U.S. A self-organizing map, which is a type of artificial neural network, is used to cluster the MSAs and compare their regional sustainability and transportation sustainability as well as to investigate the relationships among indicators. The results show that MSAs with a higher score on regional sustainability do not necessarily have a higher score on transportation sustainability. Some MSAs that are geographically close to each other have similar scores in regional sustainability and transportation sustainability. These findings provide insights to decision makers that the assessment of sustainability should consider both correlation and heterogeneity of different indicators within a region. Therefore, it is important to develop a comprehensive and efficient method to evaluate the role of sustainability in one urban sub-system, such as transportation, in the overall regional sustainability.

In this study, thymol-loaded hydrophobically modified phytoglycogen/zein nanocomplexes with a particle size around 100 nm were developed for improving microbial safety of fresh produce. The antimicrobial activities, including the determination of minimum inhibitory and bactericidal concentration, growth kinetic curves, and inhibition zone of the nanocomplexes against foodborne pathogens (Listeria monocytogenes, Salmonella enteritidis, and Escherichia coli) were evaluated. The results showed that the antimicrobial activities of the nanocomplexes were significantly stronger than that of free thymol control (without encapsulation), and the antimicrobial efficacy remained unchanged after storage at 4 °C for 60 days. The morphological results from atomic force microscope revealed that small micellar blebs were formed at the surface of bacteria after treatment with nanocomplexes and the gradual disappearance of the cell boundary indicated the occurrence of cytolysis. The potential applications of this nanocomplex as disinfectant agent in wash water were evaluated on different types of fresh produce (lettuce, cantaloupe, and strawberries). Notably, the nanocomplexes also demonstrated efficacy in biofilm removal. Findings from this study clearly demonstrated that the thymol-loaded nanocomplexes hold promising potential for the disinfection of fresh produce to improve their microbial safety and quality.

Loss Plateau of China is an area with long-term vegetation restoration while serious mass movements. Local vegetation does act as sediment reducing role while quantification of their effect on landslides is lacking. This work presents a first research work about the connection between landslides and vegetation by the example of July 25–26, 2013, extreme rainstorm. High-resolution sensing orthoimages, landside width, and simplified infinite slope theory were used to examine landslide distribution and the lateral apparent cohesion of roots. The results reveal that shallow landslides have a higher probability at the transitional slope area. The majority of them have a gradient of 20–25°, locate on south-facing slopes, and areas with sparse vegetation. Vegetation cover, represented by the Green-Red Vegetation Index (GRVI), is the controlling factor of landslide distribution and size. The estimated lateral apparent cohesion of plant roots is not positively related to GRVI, and increase when GRVI > 0.2. The relationship between landslide width and slope gradient indicates that strong root strength may result in larger landslide volume. This result of this work is a pioneering trial in correlating the lateral apparent cohesion from roots and forest crown, which is helpful for understanding the effect of vegetation on landslides.

It is generally recognized that the formation and accumulation of iron oxides on the surface of zero-valent iron (Fe0) resulting in significant decrease of contaminant degradation rates during the long-term reactions. However, in this study, we found that the removal efficiencies of p-nitrophenol (PNP) by micro zero-valent iron (mFe0) could maintain at the satisfactory level in the process of continuous reactions (20 cycles). The removal rate constant (0.1779 min−1) of the 5th cycle was 6.74 times higher than that of the 1st reaction (0.0264 min−1), even the 20th cycle (0.0371 min−1) was higher than that of the 1st reaction. Interestingly, almost no dissolved iron was detected in the solution, and the total iron concentrations decreased dramatically with the process of continuous reactions. The results of scanning electron microscope and energy dispersive spectrometry (SEM-EDS) and X-ray diffraction (XRD) revealed that the structure and composition of corrosion products change from amorphous to highly crystal with the increase of the number of cycles. The corrosion products were mainly magnetite (Fe3O4) and a small part of maghemite (γ-Fe2O3), which were in the form of microspheres on the surface of mFe0. The formation of surface oxidation shell hindered the release of Fe2+. X-ray photoelectron spectroscopy (XPS) results illustrated that partial Fe3O4 could be converted into γ-Fe2O3. Electrochemical analysis proved that the electron transfer rate of mFe0 increased with the formation of the oxides shell. However, the consumption of iron core and thicker oxide film weakened the electron transfer rate. Besides, the quenching experiments indicated that the reaction activity of mFe0 could be enhanced with the addition of scavengers. This study deepened the understanding of the structural transformation and radical production of mFe0 in continuous reactions.

Light-operated excited-state photochemical reactions and the resulting photochromic materials have gained significant attention for their promising technological applications in molecular electronic and photonic devices. To obtain photochromic materials (e.g., diarylethenes) with desired properties, the way to tune energy processes of the excited state is essentially important, from both fundamental and practical viewpoints. The modified diarylethenes mostly focused on structural improvements to achieve efficient photochromism. We report here two new spiro-conjugated indenodiarylethenes (named, SFI-Th and SFI-Sul) with an orthogonally arranged spiro π-scaffold. The spiro fluorene sterically constrains the free volume of photoactive side aromatic rings, while the spiro-conjugation points toward modulation of the decaying channels of excited-state energy, thus allowing for tuning photochromic performances. These spirodiarylethenes SFI-Th and SFI-Sul are readily accessible with low cost and show distinct photochromic and photoluminescent properties. On one hand, the SFI-Th bearing bisthienyl side rings, is an excellent photochromic switch showing high thermal stability and high fatigue resistance in both solution and amorphous state, likely benefited from steric-induced excited-state energy transfer into reversible photochemical reactions, owing to higher π-orbital spiro-conjugation between the two molecular halves. On the other hand, the SFI-Sul with bissulfonyl side rings, most notably, displays quantitative photocyclization to yield SFI-Sulc upon excitation. However, the ring-closed SFI-Sulc has an extremely slow photocycloreversion, and meanwhile immediately switches on emissive state with a strong fluorescence (Φf=0.57 in amorphous powder state). We study the modulated roles of spiro π-scaffold in both cases computationally and experimentally, and attribute the facilitated photochemical reaction to the positively electronic effects of spiro-conjugation, and the photo-responsive radiative transition to the negatively electronic effects of spiro-conjugation, respectively. In all, this work demonstrates that the spiro-conjugation is a new and efficient strategy to deliver excitation energy transfer (EET) for featured photochromic properties, due to its advantage in steric-induced electronic modulation.

Plant roots positively and negatively contribute to hillslope stability by the perspective of soil strength and water flow infiltration improvement. To further examine the controversy, this work addresses the six root architecture types on the rainfall threshold for slope stability by tests of saturated conductivity and shear strength of the root-soil composite. An infinite slope model and a 1D flow model combine to obtain the rainfall intensity-duration threshold of slope failure. The results reveal that the saturated hydraulic conductivity of root-soil composite is 1 to 4.23 times of bare soil, which increases as the length density, volume density, and volume fractal dimension of plant roots. Furthermore, plant roots can enhance the cohesion and angle of internal friction by 35.19–81.79% and 12.92–42.36%, respectively. Finally, the R-type and V-type roots have the most effective root architecture for hillslope stability. In the process of afforestation, H-type may be suitable for areas with soft slope, while V-type and R-type may be suitable for steep slopes. The results of this work present an interesting study on the interaction of plant roots on slope stability, which is worthy of further study in the future.

Purpose: Patients who have survived an acute aortic dissection remain at risk for postdissection thoracoabdominal aortic aneurysms (PD-TAAAs). Fenestrated/branched endovascular repair for PD-TAAA is increasingly used in some high-volume centers, but outcomes are still limited because of the additional challenges compared to atherosclerotic thoracoabdominal aneurysms. This study was performed to evaluate the literature on fenestrated/branched endovascular repair for PD-TAAAs. Methods: PubMed, Embase, and the Cochrane Database were searched for relevant studies published until September 2019. Outcome data were extracted to evaluate the technical success, 30-day mortality, later survival, major complications, endoleaks, target vessel patency, and reintervention. Studies were analyzed in a pooled proportion meta-analysis. Results: In total, 143 patients from 4 studies were identified for the pooled data analysis. The pooled technical success rate was 98% (95% CI: 86%-100%). After the treatment, the overall estimated 30-day mortality rate was 3% (95% CI: 1%-8%), early spinal cord ischemia rate was 10% (95% CI: 4%-21%), early renal injury rate was 5% (95% CI: 1%-19%), endoleak rate was 33% (95% CI: 22%-47%), reintervention rate at a median follow-up of 22.5 months was 34% (95% CI: 27%-42%), and all-cause mortality rate was 12% (95% CI: 6%-24%). Conclusions: The use of fenestrated/branched stent grafts for the treatment of PD-TAAA appears generally feasible based on the limited literature, but endoleaks and reinterventions are frequent.

Creating π-extended benzopentafulvalenes can aid development of novel functional materials for organic electronics. Herein, we describe a facile ring-expansion strategy to allow precise construction of benzopentafulvalenes in an asymmetric benzoannulation mode, which provides an unprecedented opportunity to extend overcrowded olefins. This ring-expansion experienced sequenced skeletal rearrangement via a crucial spirobicyclic cation intermediate, rationalized by experiments and theoretical calculations. The resulting π-extended benzopentafulvalenes showed chain length-dependent physical properties. Substituent tuning led to available π-systems exhibiting LUMO energies comparable with those of fullerenes and stable ionic radicals upon one-electron oxidation/reduction. The π-extended nonplanar molecules displayed promising air-stable ambipolar semiconducting properties with balanced carrier-transport performances in thin film-fabricated OFETs. Our study provides insights into the fundamental relationships between molecular structures and optoelectronic properties for a new class of asymmetric benzopentafulvalenes.

Two-dimensional ferroelectric materials can maintain stable polarization with atomic layer thickness, and they have a wide range of technological applications in transistors, resistive memories, energy collectors and other multi-functional sensors for highly integrated flexible electronics. Domain evolution should be considered when 2d ferroelectric material-based devices are applied in a radiation environment, which may induce radiation damage and performance degradation. In this work, we investigate the domain evolution and photodetection performance degradation of α-In2Se3 nanoflakes induced by the total dose effect of 60Co γ-rays. The phonon modes change with an increase in total dose, while the domain structure changes in α-In2Se3 based transistors. Domain evolution may be one of the main reasons for the photoresponsivity degradation of these transistors. This investigation can provide a solid base for future research, and immediate applications in 2d ferroelectric material-based devices can be contemplated.

Background Hepatocellular carcinoma (HCC) is the third major cause of cancer-related death. Mounting evidence shows that microRNAs play critical roles in the initiation and progression of HCC and may potentially serve as diagnostic markers for HCC. Methods and results In the present study, we explored the biological effects of miR-885-5p on HCC progression. We performed flow cytometry analyses of miR-885-5p in HCC cell lines and identified miR-885-5p as a recurrence-related microRNA. Overexpression of miR-885-5p significantly inhibited cell migration, invasion, proliferation, angiogenesis and EMT. Then, the correlation of miR-885-5p and AEG1 were confirmed by using luciferase assays, quantitative real-time PCR analysis and Western blotting. It was subsequently confirmed that Astrocyte Elevated Gene1 (AEG1) was a direct target gene of miR-885-5p. Conclusion miR-885-5p likely acts as a tumor suppressor by regulating AEG1, suggesting that miR-885-5p may be a potential biomarker and can be targeted in therapeutic strategies against HCC in the future.

The discovery of layered two-dimensional (2D) ferroelectric materials has promoted the development of miniaturized and highly integrated ferroelectric electronics. The 2D ferroelectric materials can be applied in a radiation environment, in which the effect of radiation on these materials should be considered. However, the effects of radiation on 2D ferroelectric materials may be entirely different from those on traditional ferroelectric materials. Ionization effect-induced domain switching can be recovered by applying an external electric field, whereas the displacement effect initiated by radiation particles produces crystal structure damage. The displacement damage that is extremely difficult to recover may have a negative impact on the application of 2D ferroelectric materials in a radiation environment. In this study, the effect of displacement induced by neutron irradiation on the promising α-In2Se3 nanoflakes was investigated. Neutron irradiation (1 MeV) with a fluence of 1014 cm-2 was used for avoiding ionization effects in a certain range. Although the topography of α-In2Se3 does not change underneutron irradiation, vacancies have been proved to be induced by neutron irradiation; furthermore, it has been identified that the vacancies mostly originate from the loss of In atoms. The out-of-plane (OOP) and in-plane (IP) domain structures of the α-In2Se3 nanoflakes with a few layers only slighlty change. In addition, the polarization of the irradiated nanoflakes could still be reversed. All these findings show that although the vacancies may influence the band structure and polarizaiton values of α-In2Se3, the ferroelectric performance may have a strong resistance to neutron irradiation. Therefore, our investigation implies that α-In2Se3 is an excellent 2D ferroelectric material for application in radiation-resistant electronic devices in the future.

Low-light face detection is challenging but critical for real-world applications, such as nighttime autonomous driving and city surveillance. Current face detection models rely on extensive annotations and lack generality and flexibility. In this paper, we explore how to learn face detectors without low-light annotations. Fully exploiting existing normal light data, we propose adapting face detectors from normal light to low light. This task is difficult because the gap between brightness and darkness is too large and complicated at the object level and pixel level. Accordingly, the performance of current low-light enhancement or adaptation methods is unsatisfactory. To solve this problem, we propose a joint High-Low Adaptation (HLA) framework. We design bidirectional low-level adaptation and multitask high-level adaptation. For low-level, we enhance the dark images and degrade the normal-light images, making both domains move toward each other. For high-level, we combine context-based and contrastive learning to comprehensively close the features on different domains. Experiments show that our HLA-Face v2 model obtains superior low-light face detection performance even without the use of low-light annotations. Moreover, our adaptation scheme can be extended to a wide range of applications, such as improving supervised learning and generic object detection.

We recently reported that exposure to triclosan (TCS), a broad-spectrum antibacterial agent, affects social behaviors in adult mice, however, the long-lasting effects of TCS exposure during early life on social behaviors are still elusive. The present study aimed to investigate the long-lasting impacts of adding TCS to the maternal drinking water during lactation on the social behaviors of adult mouse offspring and to explore the potential mechanism underlying these effects. The behavioral results showed that TCS exposure decreased body weight, increased depression-like behavior and decreased social dominance in both male and female offspring, as well as increased anxiety-like behavior and bedding preference in female offspring. In addition, enzyme-linked immunosorbent assay (ELISA) indicated that TCS exposure increased peripheral proinflammatory cytokine levels, altered serum oxytocin (OT) levels, and downregulated the expression of postsynaptic density protein 95 (PSD-95) in the hippocampus. Morphological analysis by transmission electron microscopy (TEM) demonstrated that exposure to TCS induced morphological changes to synapses and neurons in the hippocampus of offspring. These findings suggested that TCS exposure during lactation contributed to abnormal social behaviors accompanied by increased peripheral inflammation and altered hippocampal neuroplasticity, which provides a deeper understanding of the effects of TCS exposure during early life on brain function and behavioral phenotypes.

Sensory decision-making is frequently studied using categorical tasks, even though the feature space of most stimuli is continuous. Recently, it has become more common to measure feature perception in a gradual fashion, say when studying motion perception across the full space of directions. However, continuous reports can be contaminated by perceptual or motor biases. Here, we examined such biases on perceptual reports by comparing two response methods. With the first method, participants reported motion direction in a motor reference frame by moving a trackball. With the second method, participants used a perceptual frame of reference with a perceptual comparison stimulus. We tested biases using three different versions of random dot kinematograms. We found strong and systematic biases in responses when reporting the direction in a motor frame of reference. For the perceptual frame of reference, these systematic biases were not evident. Independent of the response method, we also detected a systematic misperception where subjects sometimes confuse the physical stimulus direction with its opposite direction. This was confirmed using a von Mises mixture model that estimated the contribution of veridical perception, misperception, and guessing. Importantly, the more sensitive perceptual reporting method revealed that, with increasing levels of sensory evidence, perceptual performance increases not only in the form of higher detection probability, but under certain conditions also in the form of increased precision.

This work proposed a synthetic aperture rainbow refractometry (SARR) by synthesizing rainbow signals of the same droplet with dual-wavelength laser beams, in order to increase the aperture of rainbow refractometry. In this way, the SARR can apply to long distance and small droplets measurement. An achromatic imaging system, which simultaneously records while separating the two rainbow signals in two channels of a color image, is elaborately designed. A data processing algorithm is developed to retrieve the optimal droplet refractive index and size. Numerical simulations of different droplet sizes from 10 μ m to 200 μ m certify the viability of the SARR. Proof-of-concept experiments of micron-sized ethanol droplets are performed with 1650 mm measurement distance. Results show that the SARR can accurately measure droplet refractive index and size with uncertainties of 2.3 × 10−4 and 2 μ m, respectively. The feasibility and accuracy of the proposed SARR are successfully demonstrated, paving the way for rainbow refractometry applied to large-scale industrial applications.

Doping is of great importance to tailor the electrical properties of semiconductors. However, the present doping methodologies for organic semiconductors (OSCs) are either inefficient or can only apply to some OSCs conditionally, seriously limiting their general applications. Herein, a novel p-doping mechanism is revealed by investigating the interactions between the dopant trityl tetrakis(pentafluorophenyl) borate (TrTPFB) and poly(3-hexylthiophene) (P3HT). It is found that electrophilic attack of the trityl cations on thiophenes results in the formation of tritylated thiophenium ions, which subsequently induce electron transfer from neighboring P3HT chains to realize p-doping. This unique p-doping mechanism enables TrTPFB to p-dope various OSCs including those with high ionization energy (IE ≈ 5.8 eV). Moreover, this doping mechanism endows TrTPFB with strong doping capability, leading to doping efficiency of over 80% in P3HT. The discovery and elucidation of this novel doping mechanism not only points out that strong electrophiles are a class of efficient p-dopants for OSCs, but also provides new opportunities toward highly efficient doping of various OSCs.

An increasing number of studies have demonstrated extensive functional links between bone and the brain. As a novel endocrine organ, bone has received increasing attention for its upregulatory functions in the brain. Sclerostin, a novel bone-derived endocrine molecule, secreted by osteocytes, can inhibit the bone morphogenetic protein (BMP) and wingless/integrated (Wnt) signaling pathways to regulate bone formation, but its effects on the central nervous system and neurosocial behaviors are unknown. This study investigated the effects of intracerebroventricular sclerostin injection on social-emotional behaviors in adult mice. The results showed that acute elevation of sclerostin levels in the brain could induce anxiety-like behaviors and reduce the social hierarchy of mice while reducing the dendritic complexity of pyramidal neurons in the mouse hippocampus. These data suggested that sclerostin may regulate social-emotional behaviors, providing new evidence for the existence of a bone-brain axis, new insights into the regulation of social behaviors by bone-derived endocrine molecules, and a new direction for the study of individual emotional behavior regulation.

Reduction of an iminium C═N double bond is the most important phase I metabolism process associated with the cytotoxic property of quaternary benzophenanthridine alkaloids (QBAs). Inspired by the light-mediated reduction of QBAs with nicotinamide adenine dinucleotide, a visible-light-promoted reductive functionalization reaction of QBAs is reported in this study. C4-Alkyl-1,4-dihydropyridines (DHPs) enable the direct reductive alkylation of QBA independently, serving as both single-electron-transfer reductant reagents under irradiation with 455 nm blue light in the absence of photocatalysts and additional additives. Our protocol can be further applied to the semisynthesis of natural 6-substituted dihydrobenzophenanthridine derivatives such as O-acetyl maclekarpine E.

Green infrastructure (GI) has been recommended widely to reduce runoff from the built environment. However, reliance on public land for GI implementation could cause a heavy financial burden on local governments. Although economic incentives and market-based mechanisms may encourage public participation in managing stormwater by installing GI on private parcels, a runoff trading market has not been fully developed in practice. To establish a market, in part, requires a watershed-based planning framework and fully informed parcel owners in regard to tradable credits, costs, and benefits. We propose a scenario-based Stormwater Management Planning Support System for Trading Runoff Abatement Credits (SMPSS-TRAC) to facilitate the calculation and allocation of stormwater runoff abatement credits in order to assist the decision-making of GI investment. We apply SMPSS-TRAC to a watershed located in Hamilton County, Ohio, USA and develop five scenarios representing increasing use of GI. We test the scenarios under a 5-year rainfall intensity and set a cap of runoff for each scenario at a level that is equal to the runoff from an undeveloped status (1.03-inch runoff depth for the watershed). With the proposed SMPSS-TRAC, the watershed authority could encourage all parcel owners to install suitable GI or purchase credits from the market. When detention basins are needed to meet a stated goal, the watershed authority would build them on vacant lots and share costs with all parcels within the same sub-catchment. The last scenario with four types of GI installed, shows that the watershed reaches market equilibrium and generates 15,358 m(3) credit surplus. SMPSS-TRAC has the potential for including multiple stakeholders’ preferences and concerns in searching for preferable scenarios.

Depression is the root of various diseases. It is one of the most debilitating conditions globally. Antidepressant drugs are usually the first-line of depression treatment. Arctigenin (ARC), one of active ingredient of Arctium lappa L, has been found to exert neuroprotective, anti-decrepitude, and anti-inflammatory activities. Thus, the aim of this study was to investigate the potential antidepressant- and anxiolytic-like effects of ARC using acute and chronic mild stress (CMS) mice model. ICR mice model received acute stress or chronic mild stress assessed by open field test (OFT), novelty suppressed feeding (NSF), sucrose preference test (SPT), forced-swimming test (FST), and tail suspension test (TST). After the final test, blood was collected to detect the serum levels of angiogenin (ANG), thrombopoietin (TPO), and vascular endothelial growth factor (VEGF) by enzyme-linked immunosorbent assay (ELISA). The behavioral results showed that repeated ARC (10, 30 mg/kg) administration significantly relieved the antidepressant- and anxiolytic-like effects. And repeated ARC administration at the dose of 10 and 30 mg/kg could significantly block depressive- and anxiety-like behaviors caused by CMS. Finally, ELISA results showed that ARC administration increased the serum levels of angiogenin (ANG), thrombopoietin (TPO), and vascular endothelial growth factor (VEGF). Results showed that chronic ARC administration produces antidepressant- and anxiolytic-like effects, which provides direct evidence for the first time that ARC may be a novel strategy for the treatment of depression and even stress-related disorders. The present data supports further exploration for developing ARC administration as a novel therapeutic strategy for depression and even stress-related disorders.

Many governments around the world have used the precautionary principle as the foundation in developing public policies since the late twentieth century. The principle stipulates that governments shall be obligated to restrict or ban activities that may cause serious and/or irreversible harm to human health and the environment, even without fully established scientific evidence of causal relationship. Further, the proposers of the activities must demonstrate that those activities will not cause serious harm. The precautionary principle has received criticisms, and these range from ignoring the benefits from proposed activities or overlooking the harm from inaction, having bias toward nature, to imposing an impossible burden of proof on the action proposers. Some of the debates have revealed the misuse of the principle and the need for clarification and specification. Other differences of opinion can be attributed to the uncertainties of the future since neither the proponents nor the opponents of the principle can be certain about the outcome of a proposed action. Therefore, socio-ecological practitioners need more knowledge implementation and impact research to produce actionable guidance on implementing the precautionary principle for sustaining human settlements. The recent progress of ecological wisdom has the potential to provide a fresh perspective for applying the precautionary principle. After describing ecological wisdom, this essay demands that pursuing benefits and avoiding problems are everyone’s responsibility. All involved stakeholders have the same moral obligation to internalize knowledge, experience, and ethical values in decision-makings that affect humans and the environment they rely on.

A visible-light mediated photoredox-catalyzed sulfonamidation of enol acetates to α-amino ketones has been developed. Upon irradiation with a blue LED (λ 425 ± 15 nm) in the presence of catalytic amounts of Ir(ppy)3 (2 mol%), N-arylsulfonyl-1-aminopyridine salts were transformed into N-centered radical intermediates, which then underwent coupling with enol acetates to give α-sulfonylamino ketones in up to 83% yield. The process features mild and operationally simple reaction conditions and does not require an external oxidant.

Starting in 2013, China's key polluting firms have been required to install continuous emissions monitoring systems (CEMS) and to publish the data for real-time oversight and public scrutiny. However, the CEMS data has rarely been used in local environmental law enforcement because its quality is still of great concern. A lack of criteria to evaluate data quality is one of the causes. In this paper, we design a comprehensive analytical framework for evaluating the quality of CEMS data, which includes completeness, accuracy, and authenticity. To demonstrate the applicability of the framework, we build a CEMS dataset for key polluting firms in Henan province from 2017 to 2019 by scraping the CEMS data from a public platform. We then conduct a comprehensive evaluation using our proposed framework. Some data quality issues are identified. About one-third of the firms did not meet official guidelines for data completeness. When comparing the CEMS data with onsite measurement results, we observe statistically significant inconsistencies in about one-fifth of the firms. In addition, we find evidence that some firms might manipulate CEMS data by strategically turning down the CEMS when a pollutant's concentration is expected to exceed the limit. Our framework can be expanded by incorporating more evaluation methods and data. We suggest that government agencies should implement a comprehensive framework to enhance the quality of CEMS data, thereby facilitating its application in law enforcement.

In this work, α-In 2 Se 3 based transistors with channel widths of 20 μm have been irradiated with 60Co γ-rays. The radiation induced photoresponsivity degradation, radiation stability, and time annealing effect on α-In 2 Se 3 based transistor have been investigated. Both the radiation induced domain evolution and the time annealing effect decrease the photoresponsivity of α-In 2 Se 3 based transistor. Phonon modes, domain structure, and surface topography of the α-In 2 Se 3 nanoflakes have been investigated in details for revealing the mechanism of the photoresponsivity degradation. The results show that the surface topography damage of α-In 2 Se 3 may be the main factor affecting the radiation stability in the time annealing. It is very interesting that the in-situ electric stress can heal the photoresponsivity decreased by the time annealing effect, because the captured free carriers can be freed by the voltage sweeping. Considering that the α-In 2 Se 3 based transistors can still be used as photodetectors after an irradiation of 1 Mrad(Si) and a time annealing of one year, α- In 2 Se 3 is promising for photodetector in extreme environmental conditions.

Triclosan (TCS), a newly identified environmental endocrine disruptor (EED) in household products, has been reported to have toxic effects on animals and humans. The effects of TCS exposure on individual social behaviors and the potential underlying mechanisms are still unknown. This study investigated the behavioral effects of 42-day exposure to TCS (0, 50, 100 mg/kg) in drinking water using the open field test (OFT), social dominance test (SDT), social interaction test (SIT), and novel object recognition task (NOR). Using 16S rRNA sequencing analysis and transmission electron microscopy (TEM), we observed the effects of TCS exposure on the gut microbiota and ultrastructure of hippocampal neurons and synapses. Behavioral results showed that chronic TCS exposure reduced the social dominance of male and female mice. TCS exposure also reduced social interaction in male mice and impaired memory formation in female mice. Analysis of the gut microbiota showed that TCS exposure increased the relative abundance of the Proteobacteria and Actinobacteria phyla in female mice. Ultrastructural analysis revealed that TCS exposure induced ultrastructural damage to hippocampal neurons and synapses. These findings suggest that TCS exposure may affect social behaviors, which may be caused by altered gut microbiota and impaired plasticity of hippocampal neurons and synapses.

Summary Organic-inorganic lead halide perovskite solar cells (PSCs) have received much attention in the last few years due to the high power conversion efficiency (PCE). Generally, perovskite/charge transport layer interface and the defects at the surface and grain boundaries of perovskite film are important factors for the efficiency and stability of PSCs. Herein, we employ an extended benzopentafulvalenes compound (FDC-2-5Cl) with electron-withdrawing pentachlorophenyl group and favorable energy level as charge transfer molecule to treat the perovskite surface. The FDC-2-5Cl with pentachlorophenyl group could accept the electrons from perovskite as a p-type dopant, and passivate the surface defects. The p-type doping effect of FDC-2-5Cl on perovskite surface induced band bending at perovskite surface, which improves the hole extraction from perovskite. As a result, the PSC with FDC-2-5Cl treatment achieves a PCE of 21.16% with an enhanced open-circuit voltage (Voc) of 1.14 V and outstanding long-term stability., Graphical abstract, Highlights • A benzopentafulvalene compound (FDC-2-5Cl) is used to treat the perovskite film • The FDC-2-5Cl could induce p-type doping and passivation effect on perovskite film • The device with treatment achieves a PCE of 21.16% with a high Voc of 1.14 V • The unencapsulated devices with passivation exhibit outstanding stability, Energy Engineering; Surface Treatment; Energy Materials

While the focus of the wide-spread coronavirus is its impacts on people’s lives and economic wellbeing around the world, the pandemic substantially limits people’s available options of physical activities and exacerbates an enduring problem of large urban populations lack accessible green space to fulfill the essential physical and mental health needs. Under the current pandemic situation available green space is further reduced when some parks are closed or open with limited functions to reduce the spread of coronavirus. At the same time, the demand for green space has increased because of the unavailability of other activities. In this essay, we call the attention of urban planners and designers to pocket parks. Studies have shown that the tiny size of pocket parks makes them an easier fit into vacant properties scattered throughout the urban fabric. Therefore, pocket parks can improve health and encourage social cohesion of residents in often underserved high density urban neighborhoods. The potential of pocket parks in providing accessible urban green space to all urban population may have been considered desirable before the coronavirus outbreak and now it should be considered a necessary ‘lifeline’ to improve urban residents’ health during the coronavirus. In addition, with the long-overlooked value of accessible urban green space waken by the global-scale crisis, proper attention and improvement strategy, such as introducing more pocket park could lead to a better future after the COVID-19.

Post-traumatic stress disorder (PTSD) is characterized by an enhancement of traumatic memory. Intervention strategies based on the different stages of memory have been shown to be effective in the prevention and control of PTSD. The endogenous gaseous molecule, sulfur dioxide (SO2), has been reported to significantly exert neuromodulatory effects; however, its regulation of learning and memory remains unestablished. This study aimed to investigate the effects of exogenous SO2 derivatives administration on the formation, consolidation, reconsolidation, retention, and expression of contextual fear memory. Behavioral results showed that both intraperitoneal injection (50 mg/kg, ip) and hippocampal infusion (5 μg/side) of SO2 derivatives (a mixture of sodium sulfite and sodium bisulfite, Na2SO3/NaHSO3, 3:1 M/M) significantly impaired consolidation but had no effect on reconsolidation and retention of contextual fear memory. These findings suggest that the attenuating effects of SO2 on the consolidation of fear memory involves, at least partially, the region of the hippocampus. The findings of this study provide direct evidence for the development of new strategies for PTSD prevention and treatment involving the use of gaseous SO2.

This study explores the use of Transformer-based models for the automated assessment of children’s non-native spontaneous speech. Traditional approaches for this task have relied heavily on delivery features (e.g., fluency), whereas the goal of the current study is to build automated scoring models based solely on transcriptions in order to see how well they capture additional aspects of speaking proficiency (e.g., content appropriateness, vocabulary, and grammar) despite the high word error rate (WER) of automatic speech recognition (ASR) on children’s non-native spontaneous speech. Transformer-based models are built using both manual transcriptions and ASR hypotheses, and versions of the models that incorporated the prompt text were investigated in order to more directly measure content appropriateness. Two baseline systems were used for comparison, including an attention-based Long Short-Term Memory (LSTM) Recurrent Neural Network (RNN) and a Support Vector Regressor (SVR) with manually engineered content-related features. Experimental results demonstrate the effectiveness of the Transformer-based models: the automated prompt-aware model using ASR hypotheses achieves a Pearson correlation coefficient (r) with holistic proficiency scores provided by human experts of 0.835, outperforming both the attention-based RNN-LSTM baseline (r = 0.791) and the SVR baseline (r = 0.767).

With the increasing demand for wireless data, more and more Wi-Fi devices are being constructed. Recently, people are not satisfied that Wi-Fi is only used for data exchange. Wi-Fi starts to be used for sensing in various scenarios. To understand the fundamental technology and the development trends of Wi-Fi sensing, this paper provides a comprehensive survey of resent application and performance of Wi-Fi sensing to describe the fundamental technology. Based on the sensing objects, this paper divides Wi-Fi sensing into two categories: dynamic sensing and static sensing. With the emergence of new Wi-Fi technology, Wi-Fi sensing will be developed. This paper also analyses two research trends of Wi-Fi sensing including multi-antenna fusion and multi-sensor fusion, three research challenges: limitation, robustness, and practicality, promising research directions in applications of Wi-Fi sensing.

In practical pattern recognition, e.g., image classification or recognition, the problem of missing modality, i.e., new patterns never trained by a learner pop up, can cause a dramatic decrease on the recognition accuracy. Existing algorithms as few-shot learning (FSL) and zero-shot learning (ZSL) have not sufficiently used information from other users or clients. If patterns or knowledge from other sources can be utilized as much as possible, the damage of missing modality is expected to be reduced. Privacy protection must be considered when trying to fetch information from other users. Motivated by these, an enhanced federated learning with linear discriminant analysis (LDA) is developed here. The data of each user is regarded as a client, and the features of each client are first extracted with neural network-based classification. These features are uploaded to the central server and then aggregated with LDA as a central classification to possibly achieve all patterns’ features. The trained LDA is then downloaded to the client to fulfill the pattern recognition. The proposed algorithm is applied to an image classification, and the experimental results demonstrate its efficiency in dealing with pattern recognition with missing modality.

Aortic dissection (AD) is one of the most fatal cardiovascular emergency. At the anatomical level, AD occurs due to the formation of intimal tears. However, the molecular mechanism underlying this phenomenon remains unknown. Angiotensin II (Ang II) is a important effector in the development of cardiovascular disease that acts through binding to angiotensin type 1 receptor (AT1R). Yes-associated protein (YAP) was recently recognized as a key protein in macrophage activation. To determine whether AT1R and YAP are involved in macrophage-induced endothelial cell (EC) inflammation and AD incidence, we co-cultured THP-1 cells and HAECs in transwell chambers under different culture conditions and apply different conditions to the AD mice model. The results showed that Ang II promoted macrophage M1 polarization and adhesion, upregulated YAP phosphorylation, and induced EC injury that was related to increased levels of multiple pro-inflammatory chemokines. Blocking AT1R function pharmacologically or by transfection with AT1R siRNA can reduce the pro-inflammatory effect induced by Ang II. In addition, siRNA knock down of YAP expression further aggravated the pro-inflammatory effects of Ang II. Treatment with ARB effectively alleviated these pro-inflammatory effects. In the mice AD model, ARB effectively reduced the incidence of AD in mice, decreased M1 macrophages infiltration and AT1R content in the aortic wall and increased the tissue content of YAP. We found that AT1R induces YAP phosphorylation through binding to Ang II, and further promotes macrophage M1 polarization and adhesion to ECs. ARB reduces the incidence of AD in mice and affect macrophage polarization in mice aorta.

Vascular smooth muscle cells (VSMCs) are stromal cells of the vascular wall and are continually exposed to mechanical signals. The loss of VSMCs is closely related to the occurrence of many vascular diseases, such as aortic aneurysms and aortic dissection. The proliferation and apoptosis of VSMCs are mechanically stimulated. Yes-associated protein (YAP), one of the core components of the Hippo pathway, plays a key role in the response of VSMCs to mechanical signals. In this study, we tested the impact of different intensities of mechanical stretch on the proliferation and apoptosis of VSMCs, as well as YAP. We tested VSMCs’ proliferation and apoptosis and YAP reaction via immunocytochemistry, western blotting, CCK-8 and flow cytometric analysis. We found that 10% elongation could increase the phosphorylation of YAP and prevent it from entering the nucleus, as well as inhibit cell proliferation and promote apoptosis. However, 15% elongation reduced YAP phosphorylation and promoted its nuclear entry, thereby promoting cell proliferation and inhibiting apoptosis. Accordingly, YAP knockdown suppressed the phenotype of VMSCs induced by 15% elongation. Taken together, YAP regulates proliferation and apoptosis of VSMCs differently under different intensity of mechanical stretch. Mechanical stretch with appropriate intensity can promote the proliferation and inhibit apoptosis of VSMCs by activating YAP.

Van der Waals (vdW) material Fe5GeTe2, with its long-range ferromagnetic ordering near room temperature, has significant potential to become an enabling platform for implementing novel spintronic and quantum devices. To pave the way for applications, it is crucial to determine the magnetic properties when the thickness of Fe5GeTe2 reaches the few-layers regime. However, this is highly challenging due to the need for a characterization technique that is local, highly sensitive, artifact-free, and operational with minimal fabrication. Prior studies have indicated that Curie temperature T C can reach up to close to room temperature for exfoliated Fe5GeTe2 flakes, as measured via electrical transport; there is a need to validate these results with a measurement that reveals magnetism more directly. In this work, we investigate the magnetic properties of exfoliated thin flakes of vdW magnet Fe5GeTe2 via quantum magnetic imaging technique based on nitrogen vacancy centers in diamond. Through imaging the stray fields, we confirm room-temperature magnetic order in Fe5GeTe2 thin flakes with thickness down to 7 units cell. The stray field patterns and their response to magnetizing fields with different polarities is consistent with previously reported perpendicular easy-axis anisotropy. Furthermore, we perform imaging at different temperatures and determine the Curie temperature of the flakes at ≈300 K. These results provide the basis for realizing a room-temperature monolayer ferromagnet with Fe5GeTe2. This work also demonstrates that the imaging technique enables rapid screening of multiple flakes simultaneously as well as time-resolved imaging for monitoring time-dependent magnetic behaviors, thereby paving the way towards high throughput characterization of potential two-dimensional (2D) magnets near room temperature and providing critical insights into the evolution of domain behaviors in 2D magnets due to degradation.

Evaporation behavior of nanofluid droplets within a fuel cloud plays an important role in most applications. Reported here is an experimental study on the evaporation characteristics of a monodisperse droplet stream of pure ethanol containing aluminum nanoparticles with varying concentrations (up to 0.3 wt.%) at different environmental temperatures (296–743 K). The recently developed phase rainbow refractometry (PRR) is used to simultaneously measure droplet temperature, size, and size variation of nanoscale. The results show that droplet evaporation under the experimental conditions still follows the classical D 2 -law. Furthermore, the addition of aluminum nanoparticles gradually decreases the evaporation rate. And a 16.2% reduction in the evaporation rate constant is observed when n-Al concentration increases to 0.3 wt.%. The effect of interactions between droplets on evaporation is quantified by combining with isolated droplet evaporation constant predicted by the theoretical model. And the quantified interaction effect is compared with the proposed empirical correlation, indicating that the interaction effect on the evaporation is similar for the studied range of n-Al concentration.