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608 results on '"YAVUZ, DİLEK"'

105. Endocrine Effects of Coffee Consumption

Author

YAVUZ, DİLEK, APAYDIN, TUĞÇE, Dincer, Ceyda, Apaydin, Tugce, and Gogas Yavuz, Dilek

Subjects
fertility, DECAFFEINATED COFFEE, TYPE-2 DIABETES-MELLITUS, CAFFEINE CONSUMPTION, Coffee, osteoporosis, POSTMENOPAUSAL WOMEN, hyroid diseases, diabetes mellitus, SEMEN QUALITY, TEA CONSUMPTION, RISK-FACTORS, HORMONE-BINDING GLOBULIN, CIGARETTE-SMOKING, BONE-MINERAL DENSITY, onadal hormones
Abstract

Caffeine has been found to exert various biological effects including, antiangiogenic, antiproliferative, antimetastatic activity, increased fat oxidation and mobilization of glycogen in muscle, increased lipolysis, and reduction of body fat. The aim of this review is to analyze the endocrine effects of coffee consumption. A systematic literature search was conducted on PubMed and Web of Science databases seeking articles published until May 2019, dealing with coffee consumption and diabetes, osteoporosis, thyroid gland, adrenal, and gonads. The results of the most epidemiologic studies reported that coffee consumption has positive effects on combating type 2 diabetes risk, has no significant effects on bone mineral density levels but fracture risk was shown to be higher in the high coffee consumer group. Coffee intake has no significant effect on thyroid cancer, increases sex hormone binding globulin levels, has no effect on fertility but higher consumption was related to spontaneous abortion. Studies pertaining to coffee consumption and endocrine effects have contrary results. More randomized clinical studies with a long term follow up period are required.

Published
2020

108. Clinical predictors of incipient vertebral fractures and bone mineral density in kidney transplant patients

Author

Yavuz, Dilek Gogas, primary, Aydin, Kadriye, additional, apaydin, tugce, additional, Velioglu, Arzu, additional, Mert, Meral, additional, pekkolay, zafer, additional, Parmaksiz, Ergun, additional, Mese, Meral, additional, Pazir, Ayse Esen, additional, Aydın, Emre, additional, Bugdayci, Onur, additional, and Tuglular, Serhan, additional

Published
2021
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113. Clinical characteristics of subjects with very high serum 25 OH vitamin D levels in turkey: DeVIT-TOX survey

Author

Kutbay Nilufer Ozdemir, Önder Çağatay Emir, Yavuz Dilek Gogas, Seher Tanrikulu, Firat Sevde Nur, Adnan Yay, Isilay Taskaldiran, Mustafa Eroğlu, Ersen Karakilic, Kader Ugur, Adnan Batman, Tuzcu Alpaslan Kemal, Zeliha Hekimsoy, Eylem Cagiltay, Saygili Emre Sedar, Imga Narin Nasiroglu, Atak Burcu Meryem, Faruk Kılınç, Hikmet Soylu, Zafer Pekkolay, Tülay Omma, Ömercan Topaloğlu, Altuntaș Seher Çetinkaya, and Pazır Ayșe Esen

Subjects
medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, High serum, Vitamin D and neurology, Medicine, business
Published
2020
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125. Prevalence of Vitamin D Deficiency and Hypervitaminosis D Among Adult Patients Admitted to the Tertiary Care Hospitals in Turkey.

Author

Gogas Yavuz, Dilek, Ersoy, Reyhan, Altuntaş, Yüksel, Bilen, Habip, Pamuk, Barış, Apaydın, Tuğçe, Temizkan, Şule, Altuntaş, Hasan, Mert, Meral, Akalın, Ayşen, Sert, Murat, Yıldırım Şimşir, Ilgın, Hekimsoy, Zeliha, Cantürk, Zeynep, Alphan Üç, Ziynet, İplikçi, Süleyman, Yaşar, Mehmet, Unubol, Mustafa, Sezer, Kerem, and Toplaoğlu, Ömercan

Subjects
HYPERVITAMINOSIS, AGE distribution, TERTIARY care, RETROSPECTIVE studies, VITAMIN D, HOSPITAL care of teenagers, HOSPITAL care, HOSPITAL care of older people, DISEASE prevalence, VITAMIN D deficiency, ADULTS, MIDDLE age
Abstract

Objective: Vitamin D deficiency is a common health problem around the world. This study aimed to evaluate the nationwide prevalence of vitamin D status in tertiary care hospitals in Turkey. Methods: Retrospectively, the data on vitamin D levels from 33 tertiary care hospitals' clinical biochemistry laboratories around Turkey between January and December were collected. Results: In total, 706 434 serum samples from adult subjects (female/male: 469 028/237 406; 66.4%/33.6%) were included. While vitamin D levels were sufficient in 20.3% (n = 14 222), they were insufficient in 21.9% (n = 154 360) and deficient in 57.8% (n = 408 882). We observed the highest rates of deficiency in those aged between 18 and 29 years (62.9%, n = 70 235) and lowest rates between 60 and 69 years (52.3%, n = 61 121) and between 70 and 79 years (52.3%, n = 32 397). Hypervitaminosis D was detected in 5.5% of adult subjects; highest rates of hypervitaminosis D were observed in those who were over 80 years (6.6%) and 70-79 years (6.5%) and the lowest in 18-29 years (2.8%). Discussion: In this cohort, over half of the subjects admitted to the tertiary care hospitals in Turkey had vitamin D deficiency and required vitamin D supplementation. The elderly population had the lowest prevalence of vitamin D insufficiency and the highest prevalence of hypervitaminosis D. [ABSTRACT FROM AUTHOR]

Published
2022
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134. Clinical characteristics of subjects with very high serum 25 OH vitamin D levels in turkey: DeVIT-TOX survey

Author

Pekkolay, Zafer, primary, Gogas, Yavuz Dilek, additional, Sedar, Saygili Emre, additional, Topaloğlu, Ömercan, additional, Emir, Önder Çağatay, additional, Soylu, Hikmet, additional, Taskaldiran, Isilay, additional, Esen, Pazır Ayșe, additional, Ugur, Kader, additional, Tanrikulu, Seher, additional, Nur, Firat Sevde, additional, Meryem, Atak Burcu, additional, Batman, Adnan, additional, Omma, Tülay, additional, Cagiltay, Eylem, additional, Ozdemir, Kutbay Nilufer, additional, Çetinkaya, Altuntaș Seher, additional, Nasiroglu, Imga Narin, additional, Karakilic, Ersen, additional, Hekimsoy, Zeliha, additional, Kılınç, Faruk, additional, Yay, Adnan, additional, Eroğlu, Mustafa, additional, and Kemal, Tuzcu Alpaslan, additional

Published
2020
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139. PrediyabetTanı ve Tedavi Rehberi2020

Author

SARGIN, MEHMET, YETKİN, İLHAN, ATMACA, AYŞEGÜL, BAKINER, OKAN SEFA, ÇORAKCI, AHMET, EVREN, BAHRİ, GÖKÇEL, ADNAN, YAVUZ, DİLEK, BAYRAKTAR, FIRAT, BİLEN, HABİB, DEMİR, TEVFİK, ŞAHİN, İBRAHİM, SARI, RAMAZAN, BALCI, MUSTAFA KEMAL, ARAZ, MUSTAFA, ERTÖRER, MELEK EDA, AYDIN, HASAN, and CANTÜRK, ZEYNEP

Published
2020

142. Clinical and demographic aspects of Paget disease of bone: a multicentric study from Turkey

Author

Deyneli, Oğuzhan (ORCID 0000-0001-6582-7031 & YÖK ID 171914), Yavuz, Dilek Gogas; Aytürk, Semra; Çetinkalp, Şevki; Bayraktar, Fırat; Kulaksızoğlu, Mustafa; Hekimsoy, Zeliha; Aydın, Hasan; Uygur, Melin; Deniz, Ferhat; İpekçi, Süleyman; Atmaca, Ayşegül; Saraç, Fulden; Özdemir, Nilüfer; Cantürk, Zeynep; Mert, Meral; Sancak, Seda; Ertörer, Eda; Duran, Cevdet; Akarsu, Ersin; Selek, Alev; Gürlek, Alper, School of Medicine, Deyneli, Oğuzhan (ORCID 0000-0001-6582-7031 & YÖK ID 171914), Yavuz, Dilek Gogas; Aytürk, Semra; Çetinkalp, Şevki; Bayraktar, Fırat; Kulaksızoğlu, Mustafa; Hekimsoy, Zeliha; Aydın, Hasan; Uygur, Melin; Deniz, Ferhat; İpekçi, Süleyman; Atmaca, Ayşegül; Saraç, Fulden; Özdemir, Nilüfer; Cantürk, Zeynep; Mert, Meral; Sancak, Seda; Ertörer, Eda; Duran, Cevdet; Akarsu, Ersin; Selek, Alev; Gürlek, Alper, and School of Medicine

Abstract

Objective: Paget disease of bone (PDB) is a metabolic bone disease that has been rarely reported in the Eastern countries. This study aimed to evaluate the clinical and demographic characteristics of patients with PDB followed up at endocrinology clinics in Turkey. Methods: an invitation was sent to tertiary endocrinology clinics to complete a survey on the demographic, clinical, radiological, and laboratory parameters, as well as treatment modalities of patients with PDB. This study enrolled clinically and radiologically proven 185 patients with PDB from 18 endocrinology centers based in 10 cities of Turkey. Results: this cohort of PDB had female preponderance (women/men: 105/80) with a mean age, during diagnosis, of 57±10 years. Most of the patients (59.6%) were symptomatic at diagnosis. Bone pain and headache were the predominant clinical symptoms. Polyostotic disease was observed in 67.5% (n=125) of patients. Frequently affected bones were skull (41.6%), pelvis (53.5%), spine (41%), and femur (25.4%). Moreover, 17 patients with skull involvement had hearing loss. Mean serum alkaline phosphatase (ALP) level (552±652 IU/L; range: 280-5762 IU/L) was over the normal reference cutoff with normal serum calcium levels. Intravenous bisphosphonates (zoledronic acid, 5 mg; pamidronate, 60-90 mg) were the most used drugs (75%) for the treatment of PDB. Most of the patients (87.1%) treated with intravenous bisphosphonates responded well, with a decrease in serum ALP level (117±114 IU/L) in the 12th month of therapy. Furthermore, 16 patients relapsed after the second year of therapy; 3 patients did not respond to the initial intravenous bisphosphonate treatment. Conclusion: the patients with PDB followed up by endocrinology clinics of Turkey exhibited polyostotic disease with classical clinical, radiological, and biochemical features and women's predominance with good response to intravenous bisphosphonate therapy., NA

Published
2020

143. Practical use of insulin degludec/insulin aspart in a multinational setting: beyond the guidelines

Author

Mehta, Roopa; https://orcid.org/0000-0002-2509-8054, Chen, Roger, Hirose, Takahisa, John, Mathew; https://orcid.org/0000-0002-6435-7995, Kok, Adri, Lehmann, Roger, Unnikrishnan, Ambika Gopalakrishnan, Yavuz, Dilek Gogas, Fulcher, Gregory, Mehta, Roopa; https://orcid.org/0000-0002-2509-8054, Chen, Roger, Hirose, Takahisa, John, Mathew; https://orcid.org/0000-0002-6435-7995, Kok, Adri, Lehmann, Roger, Unnikrishnan, Ambika Gopalakrishnan, Yavuz, Dilek Gogas, and Fulcher, Gregory

Abstract

Insulin degludec/insulin aspart (IDegAsp) is a fixed-ratio co-formulation of insulin degludec, which provides long-lasting basal insulin coverage, and insulin aspart, which targets postprandial glycaemia. This review provides expert opinion on the practical clinical use of IDegAsp, including: dose timings relative to meals, when and how to intensify treatment from once-daily (OD) to twice-daily (BID) dose adjustments, and use in special populations (including hospitalized patients). IDegAsp could be considered as one among the choices for initiating insulin treatment, preferential to starting on basal insulin alone, particularly for people with severe hyperglycaemia and/or when postprandial hyperglycaemia is a major concern. The recommended starting dose of IDegAsp is 10 units with the most carbohydrate-rich meal(s), followed by individualized dose adjustments. Insulin doses should be titrated once weekly in two-unit steps, guided by individualized fasting plasma glucose targets and based on patient goals, preferences and hypoglycaemia risk. Options for intensification from IDegAsp OD are discussed, which should be guided by HbA1c, prandial glucose levels, meal patterns and patient preferences. Recommendations for switching to IDegAsp from basal insulin, premixed insulins OD/BID, and basal-plus/basal-bolus regimens are discussed. IDegAsp can be co-administered with other antihyperglycaemic drugs; however, sulphonylureas frequently need to be discontinued or the dose reduced, and the IDegAsp dose may need to be decreased when sodium-glucose co-transporter-2 inhibitors or glucagon-like peptide-1 receptor agonists are added. Considerations around the initiation or continuation of IDegAsp in hospitalized individuals are discussed, as well as in those undergoing medical procedures.

Published
2020

148. Rönesans dönemi resim sanatında dram: Trajedi ve komedi

Author

Yavuz, Dilek, Gökçe, Nurdan, and Resim Anabilim Dalı

Subjects
Art History, Sanat Tarihi
Abstract

Bu araştırma ilkel dönemden başlayarak antik yunanda insanların tanrı dionysos adına yapılan büyüsel ritüellerden ve tapınmalardan doğan; dram trajedi ve komedi kavramlarının estetik bir değer olarak sanat yapıtına dönüşmesi ve bu dönüşmenin rönesans dönemi resim sanatına olan yansımaları ve etkileri üzerine durmaktadır. Starting from the primitive period, this research was carried out in the ancient Greek origin of the magical rituals and worship of the god Dionysus; The course focuses on the transformation of the concepts of drama tragedy and comedy into a work of art as an aesthetic value and its reflections and effects on the art of renaissance painting. 95

Published
2019

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