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The main chemical constituents of agarwood are sesquiterpenes and chromones, which can be divided into different categories depending on their molecular skeletons. Agarwoods are obtained from different plant species: Aquilaria sinensis, A. malaccensis, A. crassna, and A. subintegra. In this review, we systematically summarized the structures of 367 compounds isolated from agarwoods originating from four main species. We structurally classified all the components into 11 different types and summarized the number of compounds in each type. Different and identical components were obtained by enumerating the chemical compositions of the different species. Knowledge regarding the chemical constituents of agarwoods of different species will aid understanding of the chemical compositions of agarwoods and will subsequently identify similar compounds that can serve as standards for quality control to provide a reference for future studies on agarwoods from different species and to increase their usefulness.

In this paper, a kind of snapshot imaging spectrometer is designed by using image replication based on Wollaston prism. The system includes telephoto lens, collimator lens, Wollaston prism, the imaging lens and compensation filters. With this optical system, we can obtain two-dimensional information at different wavelengths of the same target through one time exposure. When Light beam is passing Wollaston prisms, in order to make sure that the different wavelengths will not overlap, the Wollaston prism needs to be designed with relatively large beam splitting angle. Then the incidence angle of the imaging lens is relatively large. It will increase the difficulty of the imaging lens design. We design, analyze the principle and the characteristics of the snapshot imaging spectrometer using image replication based on Wollaston prism, and design a complete set of imaging spectrometer system. The structure is complex; the aperture of the optical system must be well matched. In order to make sure that we can obtain good image quality through the single lens, but also the whole system, we design the telephoto lens which is imaging telecentric structure, the collimator lens which is objective telecentric structure. We use the multiple structures in ZEMAX to optimize the 16 spectral bands. At 56 lp·mm(-1), the MTF is close to the diffraction limit, the RMS of the SPT is in the Airy disk, proving good image quality.

Spine is one of the most important organs in the human body. One of the most commonly used method for the treatment of spinal diseases is the internal fixation and accurate placement of pedicle screw, which is a key factor of spinal surgery. However, due to the large differences as to the appearance of pedicles, it is hard to place the pedicle screw precisely, which will cause complication. Therefore, to find a new real-time intra-operative monitoring method with navigation is the direction of clinical application research. In this paper, a new method was firstly proposed. This method combined computer tomography (CT) values and near-infrared spectroscopy (NIRs) measurement data to guide the PS placement, and the relationship between NIRs parameters and CT values along the PS trajectory in vertebrae was investigated. First, we took pig vertebrae as samples and different puncture paths were planned. Second, a near-infrared monitoring device was utilized in experiments of fresh pig vertebrae to acquire the best NIRs monitoring pattern factors. Finally, the correlation function between NIRs data and CT values pattern factors was obtained. The results showed that CT values have a linear relationship with NIRs monitoring pattern factors, which provide references for real-time monitoring method in pedicle screw fixation surgery. This model can be applied in monitoring the pedicle screw implantation and alarming. The proposed method will be potential in improving the accuracy of PS placement and reduce the risk caused by the misplacement of pedicle screw.

Two new sesquiterpenoids, named dalodorin A (

In our previous investigation, we found that agarwood essential oil (AEO) has a sedative-hypnotic effect. Sedative-hypnotic drugs usually have an anxiolytic effect, where concomitant anxiety and depression are a common comorbidity. Therefore, this study further investigated the anxiolytic and antidepressant effects of AEO using a series of animal behavior tests on a restraint stress-induced mice model. The elevated plus maze (EPM) test, the light dark exploration (LDE) test, and the open field (OF) test demonstrated that AEO has a significant anxiolytic effect. Simultaneously, the tail suspension (TS) test and the forced swimming (FS) test illuminated that AEO has an antidepressant effect with the immobility time decreased. Stress can cause cytokine and nitric oxide (NO) elevation, and further lead to hypothalamic-pituitary-adrenal (HPA) axis hyperactivity. AEO was shown to dose-dependently inhibit the levels of cytokines, including interleukin 1&alpha, (IL-1&alpha, ), IL-1&beta, and IL-6 in serum, significantly decrease the mRNA level of neural nitric oxide synthase (nNOS) in the cerebral cortex and hippocampus, and inhibit the nNOS protein level in the hippocampus. Concomitant measurements of the HPA axis upstream regulator corticotropin releasing factor (CRF) and its receptor CRFR found that AEO significantly decreases the gene expression of CRF, and significantly inhibits the gene transcription and protein expression of CRFR in the cerebral cortex and hippocampus. Additionally, AEO dose-dependently reduces the concentrations of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) downstream of the HPA axis, as measured by ELISA kits. These results together demonstrate that AEO exerts anxiolytic and antidepressant effects which are related to the inhibition of CRF and hyperactivity of the HPA axis.

A new naphthalene derivative and three known compounds were isolated from the petroleum ether extract of the bulbs of Eleutherine americana by using various chromatographic techniques, such as column chromatography over silica gel and semi-preparative HPLC. Their structures were elucidated by spectroscopic date (MS, UV, IR, NMR), which were identified as eleutherol B (1), 4,8-dihydroxy-3-methoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (2), 8-hydroxy-3,4-dimethoxy-1-methylanthraquinone-2-carboxylic acid methyl ester (3), and isoeleutherine (4). Compound 1 is a new compound. The diastolic blood vessels activity of compound 1 and 2 were potent, reaching 82.5% and 85.3% at the concentration of 10 μmol·L⁻¹, which were basically the same as that of the positive drug tanshinone ⅡA.

PubMed ID: 30010907, The population dynamics of the blister beetle, Epicauta impressicornis (Pic) (Coleoptera: Meloidae) had been investigated from 2014 to 2016 in field. The results showed that E. impressicornis is univoltine and overwintered in the fifth instar in the Luodian area of Guizhou, China. The biological and ecological characteristic of the beetle were analyzed at six temperatures (i.e., 21, 24, 27, 30, 33, and 36°C) in the laboratory using the age-stage, two-sex life table. The developmental duration, longevity, and total preoviposition period were significantly shortened with increases in temperatures. The adult preoviposition periods at 24, 27, and 30°C were significantly longer than at other temperatures, while the fecundities at 27 and 30°C were significantly higher than at other temperatures. Life expectancy (? xj ) decreased with age and the reproductive value (v xj ) increased with age. The intrinsic rate of increase (r = 0.0921 d -1 ) and finite rate (? = 1.0965 d -1 ) were the highest at 33°C, followed by 30°C (r = 0.0758 d -1 , ? = 1.0788 d -1 ). Although the net reproductive rate (R 0 = 17.63 offspring) was the lowest at 36°C, the values of r (0.0724 d -1 ) and ? (1.0751 d -1 ) were higher at 36°C than those at 21, 24, and 27°C. Our analysis for a mass-rearing system showed the most efficient and economical strategy would be to rear E. impressicornis at 30-33°C. © The Author(s) 2018. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved., Program for New Century Excellent Talents in University China Tobacco Guizhou Industrial Henan Province University Innovation Talents Support Program National Natural Science Foundation of China, We thank Dr. Cecil Smith (University of Georgia, USA) for language editing of this manuscript. This research was supported by National Natural Science Foundation of China (No. 81460576), the Program of Science and Technology Innovation Talents Team, Guizhou Province, China (No. 20144001), and the Program of Excellent Innovation Talents, Guizhou Province, China (No. 20154021).

Through the systematical measurements of δ通过对高寒草甸不同坡向条件下25科86种C3植物叶片稳定性碳同位素组成(δ

Nine new polyoxypregnane glycosides, obcordatas A-I (1–9), were isolated from Aspidopterys obcordata Hemsl vines. Their structures were elucidated by extensive spectroscopic methods. Separated compounds were evaluated for antitumor activities against the human cancer cell lines AGS, SW480, HuH-7 and MCF-7, and compounds 1–6 and 9 showed selective cytotoxicity against HuH-7 cells with IC50 values of 8.7, 10.2, 7.5, 12.1, 16.5, 14.3, and 17.4 μM, respectively. Flow cytometry experiments showed that the effects of compound 1 on the cell cycle were attributable to cell cycle arrest at G1/S phase.

As a biodegradable polymer thin film, silk fibroin/chitosan composite film overcomes the defects of pure silk fibroin and chitosan films, respectively, and shows remarkable biocompatibility, appropriate hydrophilicity and mechanical properties. Silk fibroin/chitosan thin film can be used not only as metal implant coating for bone injury repair, but also as tissue engineering scaffold for skin, cornea, adipose, and other soft tissue injury repair. However, the biocompatibility of silk fibroin/chitosan thin film for mesenchymal stem cells, a kind of important seed cell of tissue engineering and regenerative medicine, is rarely reported. In this study, silk fibroin/chitosan film was prepared by solvent casting method, and the rat bone marrow-derived mesenchymal stem cells were cultured on the silk fibroin/chitosan thin film. Osteogenic and adipogenic differentiation of rat bone marrow-derived mesenchymal stem cells were induced, respectively. The proliferation ability, osteogenic and adipogenic differentiation abilities of rat bone marrow-derived mesenchymal stem cells were systematically compared between silk fibroin/chitosan thin film and polystyrene tissue culture plates. The results showed that silk fibroin/chitosan thin film not only provided a comparable environment for the growth and proliferation of rat bone marrow-derived mesenchymal stem cells but also promoted their osteogenic and adipogenic differentiation. This work provided information of rat bone marrow-derived mesenchymal stem cells behavior on silk fibroin/chitosan thin film and extended the application of silk fibroin/chitosan thin film. Based on the results, we suggested that the silk fibroin/chitosan thin film could be a promising material for tissue engineering of bone, cartilage, adipose, and skin.

A new cadinane sesquiterpenoid glucoside, 2β,7,3-trihydroxycalamenene 3-O-β-d-glucoside (

Achilles tendon reconstruction surgery is the primary clinical method for repairing acute Achilles tendon ruptures. However, the efficacy of the postoperative healing process and the recovery of physiological function are inadequate. This study examines the healing mechanism of ruptured rat Achilles tendons seamed with heparin-loaded core-shell fiber sutures fabricated via near-field electrospinning. High-heparin-concentration sutures (PPH3.0) perform better than the low-heparin-concentration sutures and commercial sutures (CSs). The PPH3.0 suture recruits fewer inflammatory cells and shows good histocompatibility in peritoneal implantation experiments. Staining of the Achilles tendon rupture repair zone demonstrates that a high heparin concentration in sutures reduces immune-inflammatory responses. Immunohistochemical analysis reveals that the transforming growth factor-β staining scores of the PPH3.0 sutures are not significantly different from those of the corresponding control group but are significantly different from those of the CSs and non-heparin-loaded-suture groups. According to vascular endothelial growth factor (VEGF) analysis, the concentration of VEGF in the group treated with the PPH3.0 suture increases by 37.5% compared with that in its control group. No significant difference in tension strength is observed between the PPH3.0 group and healthy Achilles tendons. These findings illustrate that this novel method effectively treats Achilles tendon rupture and promotes healing and regeneration.

A new bis-γ-pyrone polypropionate compound onchidione II (1), together with three known compounds, was isolated from a marine pulmonate mollusc Onchidium struma, collected at Hainan Island of China. The structure of new compound was determined by extensive spectroscopic analyses including IR, 1D and 2D NMR techniques, and chemical methods. Compounds 1-4 were evaluated for their cytotoxicity against human tumor cell lines HepG-2, A549, and MCF-2. The results showed that compounds 1 and 2 were moderate cytotoxic against HepG-2, A549, and MCF-2 cell lines, with IC

A new cadinane sesquiterpenoid glucoside, 2β,7,3-trihydroxycalamenene 3-O-β-d-glucoside (1) together with six known compounds, N-(p-trans-coumaroyl)-N-methyl tyramine (2), Cleomiscosin A (3), 9,12,13-trihydroxy-10,15-heptadecadienoic acid (4), Cytochalasin B (5), Marmesinin (6) and N-(p-trans-coumaroyl) tyramine (7) were obtained from the stem bark of Abelmoschus sagittifolius. The new structure of compound 1 was elucidated by analysing its 1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY and HR-ESI-MS spectra. Compounds 1–7 showed moderate cytotoxicity against Hela and HepG-2 human cancer cell lines.

The temperature control system is an indispensable key system for the thermal vacuum test. It is used to simulate the infrared heat flow environment of the spacecraft in orbit. In order to improve the stability and reliability of temperature control, this paper designs and develops a thermal vacuum test temperature control system based on the Modbus RTU serial communication protocol on the LabVIEW platform. The system combines the flexibility of software development on LabVIEW platform and combines the stability of serial communication with controller. This temperature control system has been used in thermal vacuum test, the control effect of overshooting within 1°C and temperature control accuracy within ±0.2°C. The system has high stability, which achieves the expected goal.

Large gradient magnetic fields simultaneously provide both strong magnetic and simulated gravitational fields. Processes in such environments are subject to the influences of these two fields. Previous studies have shown that the deposition of hydroxyapatite (HAp) coatings induced by self-assembled monolayers (SAMs) is affected by large gradient magnetic fields. To further clarify the mechanism, we examined the effects of gravitational and magnetic fields on the deposition kinetics of the SAMs and the HAp coatings via surface analysis and molecular simulation. The chemical compositions of the SAMs and the HAp coatings in the fields were detected by X-ray photoelectron spectroscopy (XPS). The ability of the SAMs to induce the deposition of apatite was investigated via first principles calculations, which were performed to obtain information about the bonding interactions between the self-assembled functional groups and the –PO 4 3− ions in simulated body fluid (SBF). The experimental results showed that the fields affected the compositions of the apatite layers. The first principles calculation results showed that the –PO 4 H 2− functional group exhibited a stronger ability to induce apatite deposition than the –COOH functional group. This result suggested that hydrogen phosphate root groups are better nucleation sites than carboxyl root groups.

Two new rotenoids, named millettiaosas A–B (1–2), together with four known compounds were isolated from the roots of Millettia speciosa. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HRESIMS. Evaluation of the two new compounds for cytotoxicity against four human cancer cell lines (MCF-7, HCT-116, A549 and HepG-2) showed moderate activities (10 μM

In our previous study, a potential Antitumor Polysaccharide (AAP-3b) was extracted from the fruit of Actinidia arguta. Several earlier studies have indicated that AAP-3b exhibits antioxidant activity. This study was designed to determine the effect of AAP-3b on cytotoxicity in human hepatoma cell line, Hep G2 cells. Hep G2 cells were cultured in the presence of AAP-3b at various concentrations (0.005-1 mg/mL) from 24 to 96 h and the percentage of cell viability was evaluated by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl Tetrazolium bromide (MTT) assay. The results showed that AAP-3b inhibited the cells viability in concentration and time dependent characteristics at concentrations (0.05-0.5 mg/mL) from 24 to 72 h. The IC50 (50% cell growth inhibitory concentration) of tumor cell proliferation inhibition from 24 to 72 h were 0.193 (95% confidence interval 0.159 to 0.234), 0.114 (95% confidence interval 0.073 to 0.170), 0.076 (95% confidence interval 0.034 to 0.137) mg/mL respectively. We found that anti-proliferative effect of AAP-3b was associated with cell cycle blocked and apoptosis on Hep G2 cells by determinations of morphological changes, cell cycle and apoptosis. These results provide new insight into the health functions of Actinidia arguta polysaccharide.

Electrospinning is a powerful method for preparing porous materials that can be applied as biomedical materials for implantation or tissue engineering or as scaffolds for 3D cell culture experiments. However, this technique is limited in practical applications because the pore size of 3D scaffolds directly prepared by conventional electrospinning is usually less than several tens of micrometres, which may not be suitable for 3D cell culture and tissue growth. To allow for satisfactory 3D cell culture and tissue engineering, the pore size of the scaffold should be controllable according to the requirement of the specific cells to be cultured. Here, we show that layer-structured scaffolds with pore sizes larger than 100μm can be obtained by stacking meshes prepared by direct-writing using the near-field electrospinning (NFES) technique. In the study, we prepared composite scaffolds made of polycaprolactone (PCL) and hydroxyapatite (HAp) via the above-mentioned method and tested the effectiveness of the novel scaffold in cell culture using mouse pre-osteoblast cells (MC3T3-E1). The pore size and the degradability of the PCL/HAp scaffolds were characterized. The results showed that the average pore size of the scaffolds was 167μm, which was controllable based on the required application; the degradation rate was controllable depending on the ratio of PCL to HAp. The biocompatibility of the scaffolds in vitro was studied, and it was found that the scaffolds showed no toxicity and that the cells could effectively attach, proliferate, and differentiate in the 3D skeleton of the scaffolds. Our studies showed that a simple modification of the preparation procedure can lead to a new way to fabricate novel layer-structured 3D scaffolds with controllable structures and pore sizes suitable for practical applications in implantation, tissue engineering and 3D cell culture.

Corporate environmental auditing mode needs the transition from dominated by government to mainly by corporate internal management in China. In this paper, firstly the concepts and goals of the corporate environmental auditing are defined, and then the content system on environmental auditing based on environmental management systems is built with expounding PDCA cycle path from the key point of auditing from regulation auditing to performance auditing. Finally, it puts forward some suggestions on how to realize environment audit based on environmental management system from the aspects of internal control environment, external power constraint, audit mode and audit organization. It is considered that corporate environmental auditing based on environmental management system is conducive to the realization of enterprise environmental audit objectives, the implementation of enterprise environmental audit work, and the development of corporate environmental audit theory.

The prevalence of various mental disorders and their age and gender specific characteristics among suicide attempters remains unclear in rural China. This study using 1:1 paired case-control design included 409 suicide attempters and 409 paired controls matched on age, gender and place of residence. Mental disorders were assessed using the Structured Clinical Interview for DSM-IV-TR Axis I Disorders. The prevalence of mental disorders was 32.3% for suicide attempters and 4.9% for paired controls. Mental disorder constituted a significant risk factor for suicide attempt with an adjusted odds ratio of 7.16 (95%CI: 3.65-14.04). The prevalence of mental disorders was higher among male than female suicide attempters. Major depressive disorder was most common in female suicide attempters while alcohol use disorder was most common in the males. The prevalence of mental disorders seemed to increase with age. Suicide attempters of higher ages were more prone to have mood disorders, especially a major depression. Suicide attempters with mental disorders differed from those without mental disorders on a number of socio-economic characteristics and suicidal behavior features. These insights should be taken into account in strategies and efforts to improve mental health care and ultimately to reduce suicidal behavior among residents in rural China.

Hydrologic responses to climate change have become a great challenge and attracted widespread attention of the researchers. The mountainous Qingyi River watershed in the southwest, China, had experienced significant climate change in the past three decades. It is necessary to investigate the hydrologic responses to these changes. Therefore, the effect of climate change on evapotranspiration (ET), surface runoff, baseflow and streamflow were assessed using Variable Infiltration Capacity (VIC) hydrologic model. The Mann–Kendall test analysis was first used to identify the long-term change in precipitation and temperature over the period of 1980–2010. It revealed that there is a significant change in annual temperature particularly in February, March, July and September, whereas an insignificant change in annual precipitation was founded. Hydrologic simulations show that hydrologic responses to climate change were varied from region to region. Surface runoff was more sensitive than ET and baseflow. Monthly variation of the hydrologic processes, especially the change in surface runoff, was mainly attributed to seasonal variation in precipitation. The results of this research can be a useful source of information for the decision making in water resources management and protection.

In this study, the Al-Li alloy plates were friction stir welded (FSW) at different welding parameters, and the effect of welding parameters on the hardness, tensile and fatigue properties of the butted and lapped FSWed joints were investigated. The experimental results showed that the ultimate strength and elongation of butted joints decreased as the heat input increasing, and the maximum ultimate strength of the joints was equivalent to 83% that of the base material. By comparison of the heat inputs during welding process at different parameter combinations, the relationship between the microstructure and mechanical property of FSWed joints was established. For the overlapped welds made in 2mm thick plates of Al-Li-S4 and 2099 alloys, the hooking defect was a typical and inevitable defect appearing on the TMAZ of both advancing and retreating sides, which would adversely damage the mechanical properties of overlapped joints. Furthermore, the length of pin significantly affected the tensile property of overlapped joints, when the length of pin varies from 2.8mm to 2.5mm, the ultimate strength increased 14% to 20%. In addition, the fatigue lifetime of overlapped joints was lower than that of butted joints and base metal.

The measure of similarity is an essential basic work in the field of pattern recognition, machine learning and data mining, etc. The shape similarity distance (SSD) which considering vector difference factors in the calculation of similarity, is an amendment of the classical distance. Based on the classical Euclidean distance, Manhattan distance and the SSD, this paper completed the clustering on the multiple datasets that contained shape features data of objects. The experimental results indicated that compared with the classical distances, the SSD can consider the characteristics of shape of theses objects to estimate their similarity.

Segregation analysis of the mixed genetic model of major gene plus polygene was used to identify the major genes for cotton yield-related traits using six generations P1, P2, F1, B1, B2, and F2 generated from the cross of Baimian 1 × TM-1. In addition to boll size and seed index, the major genes for the other five traits were detected: one each for seed yield, lint percentage, boll number, lint index; and two for lint yield. Quantitative trait locus/loci (QTL) mapping was performed in the F2 and F2:3 populations of above cross through molecular marker technology, and a total of 50 QTL (26 suggestive and 24 significant) for yield-related traits were detected. Four common QTL were discovered: qLP-3b(F2)/qLP-3(F2:3) and qLP-19b (F2)/qLP-19(F2:3) for lint percentage, qBN-17(F2)/qBN-17(F2:3) for boll number, and qBS-26b(F2)/qBS-26(F2:3) for boll size. Especially, qLP-3b(F2)/qLP-3(F2:3), not only had LOD scores

The research makes a heat balance test for the radiator system of the analog power capsule. And it also raises a correction calculation method of the fan in the closed cooling heat balance system for special vehicle and proves it by simulation. The research setting up the simulation test bed of the cooling system, conducting the heat balance test and verifying the validity of the carload test bed. Finally, the closed cooling air volume control precision and accuracy of the measurement system can meet the requirements of engineering application

Taking Hang Zhou Subway as research background, this article puts forward a new theoretical calculation suitable for subway safety evacuation, which is based on theoretical calculation of Japanese safety evacuation. The theoretical calculation can not only calculate total time necessary for safety evacuation, but also work out people's retention time on the way of different evacuation width clearly to specify the direction of improvement for subway fire-safety design. In addition, the evacuation simulation software named Pathfinder is used to simulate two evacuation situations when the train is stuck in tunnel when there is a fire. In comparison with the evacuation time and simulation result of two evacuation situations by theoretical calculation we can conclude a more accurate time necessary for safety evacuation to provide more reliable data for subway performance-based fire-protection design.

The Hycleus cichorii and Hycleus phaleratus are two species of medicinal meloids widely distributed in southwest of China. We sequenced an annotated the complete mitochondrial genomes of H. cichori...

In general, reinforced concrete frames have excellent fire resistance properties, but more and more concrete buildings collapsed in fires. The majority of past research work on the response of concrete building to fire has looked at the effects of fire upon individual structural members, and most commonly when subjected to heating from standard fire tests. At present, the fire behaviors of whole reinforced concrete frame are not adequately understood. There is a great need for development of models which consider the effects of fire on the whole structure under more realistic heating regimes. There is also a fundamental requirement for further large-scale testing of concrete structures, to observe the behavior of whole concrete structures in real fires and also for validation of advanced computer analysis tools. Accuracy and efficiency are two major concerns in finite element analysis of structural response of concrete frames in fires. In this paper, a multi-type finite elements hybrid model for simulating structural behavior of whole reinforced concrete frames in real fire is suggested.

The effects of heat treatments on the phase transformation behavior of Ti49Ni49.5Fe1V0.5 and Ti48Ni48.5Fe1V2.5 alloys were investigated. The results indicate that the alloys subjected to different heat treatments have B2 structure at room temperature. All the specimens exhibit a two-stage B2 → R → B19′ martensitic transformation on cooling, but a B19′ → B2 one-stage reverse martensitic transformation on heating except aged A1 alloy, which undergoes an abnormal two-stage transformation upon heating. The phase transformation temperatures are affected by heat treatments and V content, which can be attributed to the variation of the second-phase particles content in the matrix.

By adopting coating damage simulation research method with open circuit potential and electrochemical impedance spectroscopy, the influence of different damage levels of green organic composite coating to its protective performance has been studied. The research found that the variation of open circuit potential partly reflected the damage level of the coating. When K is less than or equal to 0.04, the coating still has favorable protective performance, while K is higher than 16, the protective performance of the coating is basically unavailable, but when K falls in between, the protective performance of the coating is fair good.

Researches about correlation between acupoints and calcium in recent more than 30 years in CNKI were retrieved, and correlative connection of acupoints with calcium were analyzed from different levels, such as acupoint part, peripheral pathway, target organs, central system, etc. It was turned out that there was a calcium ion enrichment phenomenon in acupoint part; there was possibly a certain connection between acupoint part and protein-bound Ca2+-ATPase; complex calcium ion in acupoint part influenced the effect of acupuncture; different methods of stimulating acupoint could significantly increase blood calcium content, decrease Ca/Cr ratio in urine; stimulation of acupoint could influence many target organs, improve their functions; stimulation of acupoints could influence distribution of calcium in the central nerve system. It is indicated that there is close relationship between the acupoint and calcium.

Objective: Making a glucose sensor to detect the glucose which is extracted from the tissue fluid on reverse iontophoresis. Method: In the role of the catalysis of glucose oxidase which was fixed in polyethylene oxide gel, the glucose and potassium ferricyanide were change into gluconic acid and potassium ferrocyanide. Then we could get the concentration of glucose by detecting the current which was created by the redox reaction. Results: The glucose sensors could detect the concentration of glucose in the range of 2.2~22mmol/l and have a good linear too. The conformance test results show that the deviation of multiple measurements of the same sensor is less than 2% and the reaction time is less than 1s. Conclusion: The sensors could detect the blood glucose.

Schwann cells play an important role in the peripheral nervous system, especially in nerve repair following injury, so artificial nerve regeneration requires an effective technique for obtaining purified Schwann cells. In vivo and in vitro pre-degeneration of peripheral nerves have been shown to obtain high-purity Schwann cells. We believed that in vitro pre-degeneration was simple and controllable, and available for the clinic. Thus, we co-cultured the crushed sciatic nerves with bone marrow-derived cells in vitro. Results demonstrated that, 3 hours after injury, a large number of mononuclear cells moved to the crushed nerves and a large number of bone marrow-derived cells infiltrated the nerve segments. These changes promoted the degradation of the nerve segments, and the dedifferentiation and proliferation of Schwann cells. Neural cell adhesion molecule and glial fibrillary acidic protein expression were detected in the crushed nerves. Schwann cell yield was 9.08 ± 2.01 × 10 4 /mg. The purity of primary cultured Schwann cells was 88.4 ± 5.79%. These indicate a successful new method for obtaining Schwann cells of high purity and yield from adult crushed sciatic nerve using bone marrow-derived cells.

Myocyte enhancer factor 2C (MEF2C) is a transcription factor of MADS box family involved in the early development of several human cells including muscle (i.e., skeletal, cardiac, and smooth), neural, chondroid, immune, and endothelial cells. Dysfunction of MEF2C leads to embryo hypoplasia, disorganized myofibers and perinatal lethality. The main role of MEF2C is its regulation of muscle development. It has been reported that MEF2C-knockout mice die on embryonic day 9.5 from unnatural development of cardiovascular. The effects of MEF2C are mediated by its directly-interacting proteins; therefore, the investigation of these interactions is critical in order to clarify MEF2C's biological function. In this study, we review twenty-five proteins that directly interact with MEF2C, including nineteen proteins related to muscle development, four proteins related to neural cell development, one protein related to chondroid cell development, four proteins related to immune cell development, and two proteins related to endothelial cell development. Among these proteins, the interaction of MEF2C with MRFs is important for differentiation of developing muscle cells. MEF2C interacts with Sox18 for endothelial vessel morphogenesis. The interaction of MEF2C with Cabin1 is important for maintaining T-cell inactivation. Investigating the interactions of MEF2C and its directly-interacting proteins is not only helpful to understand of the physiological function of MEF2C, but also provides a target for future rational drug design.

This study aimed to clarify the relationship between functional and dysfunctional impulsivity and attempted suicide in rural China. Data of this study came from the investigation of 407 suicide attempters and their paired non-suicide attempters matched with the same gender, age (±3 years) and residence area in six counties in rural Shandong, China. Suicide attempters accounted for a lower proportion on high functional impulsivity, but a higher proportion on high dysfunctional impulsivity than non-suicide attempters. Dysfunctional impulsivity in the male denoted a significant risk factor for attempted suicide, even after adjustment for psychiatric disorder and demographic factors. Suicide attempters with high dysfunctional impulsivity had a higher percent of family suicide history than those with low dysfunctional impulsivity. High functional impulsivity was a significant protective factor for attempted suicide in the group aged 35–59 years, but a significant risk factor in the group aged 15–34 years. Suicide attempters with low functional impulsivity had poorer economic status and older age than those with high functional impulsivity. Our findings support the key roles of functional and dysfunctional impulsivity in attempted suicide among rural residents of China.

Noninvasive prenatal screening (NIPS) sequences a mixture of the maternal and fetal cell-free DNA. Fetal trisomy can be detected by examining chromosomal dosages estimated from sequencing reads. The traditional method uses the Z-test, which compares a subject against a set of euploid controls, where the information of fetal fraction is not fully utilized. Here we present a Bayesian method that leverages informative priors on the fetal fraction. Our Bayesian method combines the Z-test likelihood and informative priors of the fetal fraction, which are learned from the sex chromosomes, to compute Bayes factors. Bayesian framework can account for nongenetic risk factors through the prior odds, and our method can report individual positive/negative predictive values. Our Bayesian method has more power than the Z-test method. We analyzed 3,405 NIPS samples and spotted at least 9 (of 51) possible Z-test false positives. Bayesian NIPS is more powerful than the Z-test method, is able to account for nongenetic risk factors through prior odds, and can report individual positive/negative predictive values.

For the purpose of recycling of cotton waste cuttings and exploring the prospect of preparation for super absorbent polymer (SAP), the high viscosity carboxymethyl cellulose (CMC) was made from cotton waste first and then the SAP was synthesized by grafting acrylic acid (AA) onto the CMC with the potassium persulfate being as initiator, N, N'-methylene bis acrylamide as crosslinker. The impact of polymerization temperature, time, initiator dosage, AA concentration, crosslinker dosage, and neutralization degree on water absorbency of SAP was studied. The optimum conditions are mass ratio of AA and CMC 7.11 g/g, initiator dosage 0.03 g/g CMC, crosslinker dosage 0.2 g/100g AA, neutralization degree 80% and polymerization time 1.5 h at 70°C of the polymerization temperature. The water retention of the polymer is good and the water absorbency reaches up to 702.5 g/g.

Exploitation and utilization of new energy and a road of green development have become the only way for the development of China’s electric power industry. Firstly, environmental effects of the trough solar thermal power generation are analyzed. Then, the investing and operating economy of Concentrating Solar Power (CSP) are studied. It concludes that CSP does well in the energy saving and emission reduction, and the unit price per kilowatt and discount rate have direct impacts on the investment cost of CSP. Finally, incentives for the development of CSP are put forward.

Sialon powder was synthesized using low grade bauxite as raw materials by carbothermal reduction-nitridation reaction. The influence of synthesizing temperatures (1300°C, 1350°C, 1400°C, 1450°C, 1500°C and 1550°C) on the phases of the final products was studied by XRD technique. β-Sialon (Z=3) formed at 1350°C and decreased when the temperature was higher than 1450°C. The optimizing reaction temperature for preparing Sialon was 1450°C. The Al2O3-SiC/Sialon composite refractories were prepared at 200°C, 400°C and 600°C for 24h with white corundum, brown corundum, SiC, Sialon powders prepared at 1450°C and calcium aluminate cement. The bulk density, apparent porosity, water absorption and bending strength of the Al2O3-SiC/Sialon composite refractories at room temperature were studied. The results show that the bulk density decreased and then increased with the enhancing of the temperature and reached the highest value of 2.43g/cm3 at 200°C. The apparent porosity and water absorption reached the lowest values of 26.68% and 10.99% at 200°C respectively. The bending strength decreased as the temperature increased, reached the highest value of 0.73MPa at 200°C.

We used whole-tree agarwood-induction technology to produce agarwood from Aquilaria sinensis trees within 20 months, and evaluated the quality of this agarwood. The results showed its characteristics were similar to those of high-grade wild agarwood in terms of texture, chemical constituents, essential oil content, and ethanol-soluble extract content, with the lattermost quality far surpassing the requirement of traditional Chinese medicine agarwood, as indicated in Chinese Pharmacopoeia 2010. To the best of our knowledge, this is first study to show that high-quality agarwood can be produced in whole A. sinensis trees via a chemically induced technology.

In the power electronic circuits, AC chopping control voltage regulation circuit through change the chopped device conduction time, it can easily change output voltage size. Load currents do not include low-order harmonic, they contain only higher harmonic which are relevant to the switch period , they are easy to filter out. So the power efficiency is high and it is characterized of high performance. This paper introduces a kind of widely used AC chopping control voltage regulation circuit and we simulate it by simulink. The result fully embodies the superiority of this kind of circuit.

The microcirculation plays a crucial role in the interaction between blood and tissues in physiological pathophysiological pharmacological and clinical states. Despite its significant role in numerous diseases including, hypertension diabetes, sepsis or multiple organ failure, visible and near-infrared light, offer a window into human and animal tissues due to reduced scattering and absorption. We review orthogonal polarization spectral (OPS) imaging method for direct visualization and quantitative assessment of human microcirculation at the bedside are limited. OPS imaging is a relatively new noninvasive method for assessment of human microcirculation without using fluorescent dyes. Recent clinical studies using OPS imaging in various pathological states have shown a wide spectrum of different clinical applications with evident impact on the diagnosis, treatment or prognosis assessment. Thus, there is a great effort to validate OPS imaging for various clinical purposes. The principles of OPS imaging, validation studies, its advantages, limitations, methods of quantitative assessment and current experience in clinical practice are also discussed.

Currently, there is a very difficult problem in coal mine, such as labor intensity and the problem of low safety factor. On the basis of the monorail load form, Roadway drivage support platform to achieve the comprehensive the integration of tunneling work platform of auxiliary transportation and roadway drivage support work.

Only when Aquilaria spp. or Gyrinops spp. trees are wounded, due to insect attack, or microbial invasion, agarwood can be successfully induced. In the present study, a fungus which can induce agarwood formation efficiently was isolated and a suitable method for its application to induce agarwood formation was developed. Rigidoporus vinctus was isolated from the inner layers from infectious A. sinensis trees. When the fermentation liquid of fungi inoculated back to A. sinensis tree, agarwood was found to be induced. In addition, a novel method called trunk surface agarwood-inducing technique (Agar-Sit) was developed to produce agarwood with R. vinctus. The alcohol soluble extract content of the agarwood, up to 38.9%, far higher than the requirement (10%) in Chinese Pharmacopoeia and the six characteristic compounds of agarwood used as Chinese Medicinal Materials were all detected. Their relative percentages of the sesquiterpenes in the essential oil were 22.76%. This is the first report of the Agar-Sit and also the application of R. vinctus in agarwood induction. According to the results, when the combination of Agar-Sit and R. vinctus is used agarwood can be induced with high yield and good quality.

Mixture of carbon black, copper and lead was used as catalyst of high-content RDX-composite-modified double base propellant. To enhance the catalytic effect and improve the flaring performance, metal oxide deposited on carbon nanotubes (CNTs) are replaced with afore-mentioned catalyst. A new type of nano-combustion catalyst is synthesized with microemulsion process. In present work, ternary diagram was adopted to analyze the essential factors which affect microemulsion, including temperature, surfactant or cosurfactant and concentration of solution in order to find the best technical parameters and thus to control the core formation and growth of oxides on the nano-template. Transmission electron microscopy (TEM) and X-ray diffraction (XRD) are applied to characterize the products. Through observation of microstructures and analysis of crystal structure, it is confirmed that nano-oxides are deposited on the surface of carbon nanotubes. Its particle size is below 50 nm. According to propellant components, a certain amount of combustion catalyst and RDX will be mixed. PbO·CuO/CNTs can catalyze thermal decomposition of RDX by thermal analysis. The results show that the new catalysts obviously accelerate the decomposition of RDX, and the peak temperature of decomposition reduce by 14.1 °C. The catalytic effect of nano-catalyst is better than original catalyst.