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Little study has illustrated the associations between inhalation of refloated soil dust and the morbidity of respiratory disease in animals. In this study, soil dust samples in arid and semiarid areas of China were collected for investigating the underlying biotoxicity and mechanisms of oxidative stress and apoptosis in rat lung induced by inhalation of refloated soil dust. The soil dust samples were collected from the arid and semiarid areas in Zhangjiakou city, located close to Inner Mongolia Plateau, China. After intratracheal instillation of soil dust, superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activities in rat lung were declined in a dose-dependent relationship, and pathology changes in lung tissue were also enhanced along with increased levels of soil dust. Meanwhile, apoptotic cells were scattered in the pulmonary epithelial and distributed in the mesenchyma, and the apoptotic index was significantly increased in rat lung instilled by soil dust. Besides, soil dust promoted Bax expression and inhibited Bcl2 expression, i.e., increased Bax/Bcl2 ratio in a concentration-dependent manner. In summary, short-term exposure to soil dust caused oxidative damage and induced apoptosis in rat lung through the regulation of Bax and Bcl2 expression.

The process of repeating shape memory cycle of the shape memory foam whose initial structure is nonauxetic is more complex. In this cases, only one-shot deformation, which will greatly limit the application of this smart metamaterial. Thus, in this study, we report a feasible approach of fabricating the original structure of shape memory foams with auxetic property based on second curing method. The commercial soft polyurethane foam material and shape memory epoxy resin was used in fabricating the shape memory auxetic foam. Polyurethane component plays role in the similar function of “auxetic mold,” while shape memory polymer act as fixing auxetic structure of foam. The negative Poisson’s ratio was achieved around −0.22. Tunable foam mechanical property was demonstrated by structural control according to its shape memory property. The functional filler was employed to realize the wireless actuation of auxetic foam. The excellent shape memory properties have been achieved as well. The combination of smart materials and metamaterial structure makes it have excellent structural mechanical properties and intelligent properties of materials, which greatly expands their potential application prospects.

The camellia flower is a famous woody plant with a long-cultivated history and high ornamental value. It is extensively planted and utilized around the world and owns a massive germplasm resource. Camellia ‘Xiari Qixin’ belongs to one of the typical cultivars in the four seasons camellia hybrids series. Due to its long flowering period, this kind of cultivar is identified as a precious resource of camellia flowers. In this study, the complete chloroplast genome sequence of C. ‘Xiari Qixin’ was first reported. Its whole chloroplast genome is 157,039 bp in length with an overall GC content of 37.30%, composed of a large single copy region (LSC, 86,674 bp), a small single copy region (SSC, 18,281 bp), and a pair of inverted repeat regions (IRs, 26,042 bp each). A total of 134 genes were predicted in this genome, including 8 ribosomal RNA genes, 37 transfer RNA genes, and 89 protein-coding genes. In addition, 50 simple sequence repeats (SSRs) and 36 long repeat sequences were detected. By comparing C. ‘Xiari Qixin’ and seven Camellia species on the chloroplast genome, seven mutation hotspot regions were identified, including psbK, trnS (GCU)-trnG(GCC), trnG(GCC), petN-psbM, trnF(GAA)-ndhJ, trnP(UGG)-psaJ, and ycf1. Phylogenetic analysis of 30 chloroplast genomes showed that the genetic relationship between C. ‘Xiari Qixin’ and Camellia azalea is quite close in evolution. These results could not only provide a valuable database for determining the maternal origin of Camellia cultivars, but also contribute to the exploration of the phylogenetic relationship and utilization of germplasm resources for Camellia.

Shape memory polymers (SMPs) are a class of smart materials with large deformation performance and variable stiffness characteristics, and have exhibited great potential in morphing skins. The thermal stimulation of SMPs is one of the hotspots in recent years. Shape memory polymer composites (SMPC) filled with conductive materials are activated by Joule heating without external heating facilities. The existing electro-induced SMPCs filled with conductive materials would limit large tension deformation, cannot be heated in a large area, or damage the heating circuit under cyclic loading. These aspects restrict the application of SMPC for morphing skins. In this work, an electro-induced SMP composite was fabricated by the styrene-based SMP incorporated with conductive elastic fabric (CEF) to remove the limiting factors as much as possible. The thermos-mechanical properties and electro-active characteristics of CEF/SMP composite were systematically investigated. The maximum strain at break of CEF/SMP composites reached 206% at 80°C, exhibiting excellent deformation performance. The resistance remained relatively stable after 50 cycles under 40% tensile strain. Furthermore, the CEF/SMP composite with a dimension of 160×160×3 mm3 was successfully heated above the glass transition temperature, demonstrating the actuating ability with a relatively large region. In general, the CEF/SMP composite is promising for the application of morphing skins.

Development of polymeric magnetic adsorbents is a promising approach to obtain efficient treatment of contaminated water. However, the synthesis of magnetic composites involving multiple components frequently involves tedious preparation steps. In the present study, a magnetic chitosan-palygorskite (MCP) nanocomposite was prepared through a straight-forward one pot synthesis approach to evaluate its lead (Pb2+) removal capacity from aqueous solution. The nano-architectural and physicochemical properties of the newly-developed MCP composite were described via micro- and nano-morphological analyses, and crystallinity, surface porosity and magnetic susceptibility measurements. The MCP nanocomposite was capable to remove up to 58.5 mg Pb2+ g−1 of MCP from water with a good agreement of experimental data to the Langmuir isotherm model (R2 = 0.98). The Pb2+ adsorption process on MCP was a multistep diffusion-controlled phenomenon evidenced by the well-fitting of kinetic adsorption data to the intra-particle diffusion model (R2 = 0.96). Thermodynamic analysis suggested that the adsorption process at low Pb2+ concentration was controlled by chemisorption, whereas that at high Pb2+ concentration was dominated by physical adsorption. X-ray photoelectron and Fourier transform infrared spectroscopy results suggested that the Pb adsorption on MCP was governed by surface complexation and chemical reduction mechanisms. During regeneration, the MCP retained 82% Pb2+ adsorption capacity following four adsorption–desorption cycles with ease to recover the adsorbent using its strong magnetic property. These findings highlight the enhanced structural properties of the easily-prepared nanocomposite which holds outstanding potential to be used as an inexpensive and green adsorbent for remediating Pb2+ contaminated water. Refereed/Peer-reviewed

Atractylodes lancea (Thunb.) DC. is a herb widely used traditionally for the treatment of gastrointestinal diseases such as gastric ulcer, spleen deficiency, and diarrhea. In China, people fry raw A. lancea (SCZ) together with wheat bran to make bran-fried A. lancea (FCZ). Ancient Chinese texts have documented that FCZ can enhance the function of regulating the intestines and stomach. Nevertheless, the effect and mechanism of SCZ and FCZ on ulcerative colitis (UC) are still unclear. The aim of this study was to compare the therapeutic effects of SCZ and FCZ and their mechanisms on dextran sulfate sodium (DSS)-induced UC in mice. The chemical constituents of SCZ and FCZ were analyzed using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) with six reference compounds. The effects of SCZ and FCZ were investigated based on their effects on weight loss, disease activity index (DAI) score, colon length shortening, goblet cell loss, and pathological changes using the colons from a mouse model of DSS-induced UC. The effects of SCZ and FCZ on levels of the inflammatory cytokines (tumor necrosis factor-[Formula: see text], interleukin-6, interleukin-1[Formula: see text], mucoprotein (MUC2), tight protein (ZO-1, occludin), and the activation of macrophages were determined using immunohistochemistry (IHC) and immunofluorescence (IF). 16s RNA sequencing technology was used to detect the composition of the intestinal flora in each group. Nontargeted metabonomics was used to detect the serum metabolite levels of mice in each group. Pearson analysis was used to determine the correlation between the intestinal flora, metabolites, and pathological indices. Reverse transcription-polymerase chain reaction was used to detect the genes of different metabolite-related enzymes. A pseudogerm free (PGF) mouse model was used to verify whether the effect of SCZ and FCZ in UC depends on the regulation of intestinal flora. SCZ and FCZ could inhibit weight loss and decrease the DAI score, colon length shortening, goblet cell loss, and the extent of pathological changes in the colons of mice with DSS-induced colitis. Moreover, SCZ and FCZ inhibited the decrease in MUC2, ZO-1, occludin, production of pro-inflammatory factors, and activation of pro-inflammatory macrophages in colonic tissue. The effect of FCZ was better than that of SCZ. SCZ and FCZ not only inhibited the abundance of harmful bacteria and increased the abundance of beneficial bacteria, but also regulated the metabolism of disease-related metabolites such as amino acid and cholesterol metabolism. Both preparations inhibited the gene expression (Slc6A7, PRODH, Sdsl, HMGCR, SREBP-2) of different metabolite-related enzymes. In the PGF mouse model, the above effects were not observed. Rhizoma Atractylodes was effective in alleviating DSS-induced UC in mice, and FCZ was found to be superior to SCZ. The mechanism of action of FCZ and SCZ is mainly related to the regulation of intestinal flora and their associated metabolites.

Organically modified clays have attracted increasing research attention for their various commercial and industrial applications, such as being carriers for pesticide delivery. Besides, the suitability and performance of commercially available organoclays could further promote their applicability. Hence, this study investigated the potential application of a commercially available alkylamine-modified montmorillonite (MMT) nanoclay as a carrier for a widely used insecticide, imidacloprid. X-ray diffraction and thermogravimetric analysis were employed to illustrate the arrangement, orientation, and conformation of surface-modifying agents (SMAs) on MMT nanoclay. It was observed that the clay was modified at an ∼1.0 cation exchange capacity, with the SMAs, especially octadecylamine, arranged in the MMT nanoclay as a bilayer to a pseudo-trilayer or a paraffin monolayer with a tilting angle of ∼25°, which indicated the nanoclay’s ability to adsorb a large amount of imidacloprid. The adsorption-desorption of imidacloprid to MMT nanoclay further confirmed this applicability. A high adsorption capacity (∼85 mg g-1) was observed, with a high reversibility in desorption, showing a hysteresis value of 0.75. Further, the adsorption kinetics and response of the nanoclay to imidacloprid revealed that, initially, a rapid sorption occurred due to a hydrophobic interaction. This was followed by a slower diffusion-controlled sorption due to hydrogen bonding to the internal binding sites. The releasing pattern of imidacloprid from the MMT nanoclay indicated its potential for the preparation of a slow-releasing pesticide formulation where the nanoclay will reduce the instantaneous release of the total amount of pesticide.

Shape memory polymers (SMPs) and SMP composites (SMPCs) have been widely employed in several fields and exhibit excellent self-actuation, deformation, and self-adaption. Establishing reasonable constitutive models is vital for understanding the shape memory mechanism and expanding its applications. Moreover, the mechanical response of SMPs under different conditions can be predicted, facilitating their precise control. The internal mechanism for the shape memory behavior in most SMPs is thermal actuation. This study reviews the theories of thermally actuated SMPs, rheological and phase transition concept models, and models combining the rheology and phase transition concepts. Furthermore, the constitutive models of particulate-reinforced SMPCs, carbon-fiber-reinforced SMPCs, and the buckling behavior of SMPCs are summarized. This study is expected to help solve the remaining issues rapidly and contribute to the establishment of rational constitutive models for SMPs and SMPCs.

Acute lung injury (ALI) is a syndrome caused by an excessive inflammatory response characterized by intractable hypoxemia both inside and outside the lung, for which effective therapeutic drugs are lacking.

It is argued that the occurrence of cold events decreases under the background of global warming. However, from the mid-1990s to the early 2010s, northern China experienced a period of increasing occurrence of low temperature extremes (LTE). Factors responsible for this increase of LTE are investigated in this analysis. The results show that the interdecadal variation of the winter mean temperature over mid- and high-latitude Eurasia acts as an important thermal background. It is characterized by two dominant modes, the “consistent cooling” pattern and the “warm high-latitude Eurasia and cold midlatitude Eurasia” pattern, from the mid-1990s to the early 2010s. The two patterns jointly provide a cooling background for the increase of LTE in northern China. Meanwhile, though the interdecadal variation of the Arctic Oscillation (AO), Ural blocking (UB), and Siberian high (SH) are all highly correlated with the occurrence of LTE in northern China, the AO is found to play a dominant role. On one hand, the AO directly affects the occurrence of LTE because of its dynamic structure; on the other hand, it takes an indirect effect by affecting the intensity of UB and SH. Further analyses show that the winter temperature in mid- and high-latitude Eurasia and the AO are independent factors that influence the increase of LTE in northern China from the mid-1990s to the early 2010s.

Aiming at the problems of poor segmentation effect, low efficiency and poor robustness of the Ransac ground segmentation algorithm, this paper proposes a radar segmentation algorithm based on Ray-Ransac. This algorithm combines the structural characteristics of three-dimensional lidar and uses ray segmentation to generate the original seed point set. The random sampling of Ransac algorithm is limited to the original seed point set, which reduces the probability that Ransac algorithm extracts outliers and reduces the calculation. The Ransac algorithm is used to modify the ground model parameters so that the algorithm can adapt to the undulating roads. The standard deviation of the distance from the point to the plane model is used as the distance threshold, and the allowable error range of the actual point cloud data is considered to effectively eliminate the abnormal points and error points. The algorithm was tested on the simulation platform and the test vehicle. The experimental results show that the lidar point cloud ground segmentation algorithm proposed in this paper takes an average of 5.784 milliseconds per frame, which has fast speed and good precision. It can adapt to uneven road surface and has high robustness.

This work analyzes and discusses the influence of human activities on the meteorological conditions related to winter haze events in Beijing, Tianjin, and Hebei (i.e., the Jing–Jin–Ji region) during 1961–2016, using the results of two numerical simulation experiments based on the Community Atmosphere Model version 5.1.1 (http://www.cesm.ucar.edu/models/cesm1.0/cam/docs/ug5_1_1/book1.html) used in the international Climate Variability and Predictability Programme (CLIVAR) Climate of the 20th Century. Detection and Attribution Project (C20C+ D&A). The results show that, under the influence of human activities, the changes in dynamical and thermal meteorological conditions related to winter haze events in the Jing–Jin–Ji region are conducive to the formation and accumulation of haze, and prevent the diffusion of pollutants. The dynamical conditions mainly include the obvious weakening of the East Asian winter monsoon (EAWM) and the enhancement of the near-surface anomalous southerly wind. The thermal conditions include the obvious increase in surface temperature, and the enhancement of water vapor transport and near-surface inversion. The relative contribution of dynamical and thermal conditions to the variation of haze days in the Jing–Jin–Ji region is analyzed using statistical methods. The results show that the contribution of human activities to the increase of haze days in the Jing–Jin–Ji region is greater than that of natural forcing for the study period. To be specific, the dynamical meteorological factors contribute more to the haze days than the thermal meteorological factors. The contribution of thermal meteorological factors is basically the same in both scenarios.

Percutaneous closure of ventricular septal defect (VSD) can effectively occlude abnormal blood flow between ventricles. However, commonly used Nitinol occlusion devices have non-negligible limitations, such as nondegradability leading to life-threatening embolization; limited device size predisposing to displacement and wear; only a few radiopaque markers resulting in inaccurate positioning. Nevertheless, the exploration of customized, biodegradable, and overall radiopaque occluders is still vacant. Here, overall radiopaque, biodegradable, and dynamic reconfigurable 4D printed VSD occluders are developed. Based on wavy bionic structures, various VSD occluders are designed and manufactured to adapt to the position diversity of VSD. The customized configuration, biocompatibility, and biodegradability of the developed 4D printed bionic occluders can eliminate the series of complications caused by traditional occluders. The overall radiopacity of 4D printed VSD occluders is validated ex vivo and in vivo, whereby accurate positioning can be assured. Notably, the preparation strategies for 4D printed occluders are scalable, eliminating the barriers to mass production, and marking a meaningful step in bridging the gap between modeling and clinical application of 4D printed occlusion devices. This work opens attractive perspectives for the rapid manufacturing of customized intelligent medical devices for which overall radiopacity, dynamic reconfigurability, biocompatibility, and biodegradability are sought.

An indentation method to determine the properties of hyperelastic thin films is proposed, which is to use a spherical indenter to indent on the film with a small circular hole in the center. During this progress, there exists a maximum indentation load before penetration. Considering geometries of the film and the indenter, the specific form of relationship between the maximum indentation load and the elastic properties of the film is developed for neo-Hookean, Arruda-Boyce, and Ogden hyperelastic constitutive models. On the basis of this relationship, the initial shear modulus of the film can be directly obtained from single data of the maximum load, instead of recording and fitting to indentation curves. Furthermore, other properties of hyperelastic materials are explored from the perspective of the inverse problem. The experiments are performed with natural rubber, silicone rubber, and polydimethylsiloxane (PDMS) films to verify the feasibility of our method, and the optimal radius ratio between the indenter and the hole is concluded from the experimental results.

Atractylodin (ATL) has been reported to exert anti-inflammatory effects. Osteogenic changes induced by inflammation in valve interstitial cells (VICs) play a key role in the development of calcified aortic valve disease (CAVD). This study aimed to investigate the anti-calcification effects of ATL on aortic valves. Human VICs (hVICs) were exposed to osteogenic induction medium (OM) containing ATL to investigate cell viability, osteogenic gene and protein expression, and anti-calcification effects. Gas chromatography-mass spectroscopy (GC-MS) metabolomics analysis was used to detect changes in the metabolites of hVICs stimulated with OM before and after ATL administration. The compound-reaction-enzyme-gene network was used to identify drug targets. Gene interference was used to verify the targets. ApoE-/- mice fed a high-fat (HF) diet were used to evaluate the inhibition of aortic valve calcification by ATL. Treatment with 20 μM ATL in OM prevented calcified nodule accumulation and decreases in the gene and protein expression levels of ALP, RUNX2, and IL-1β. Differential metabolite analysis showed that D-mannose was highly associated with the anti-calcification effect of ATL. The addition of D-mannose prevented calcified nodule accumulation and inhibited succinate-mediated HIF-1α activation and IL-1β production. The target of ATL was identified as GLA. Silencing of the GLA gene (si-GLA) reversed the anti-osteogenic differentiation of ATL. In vivo, ATL ameliorated aortic valve calcification by preventing decreases in GLA expression and the up-regulation of IL-1β expression synchronously. In conclusion, ATL is a potential drug for the treatment of CAVD by targeting GLA to regulate D-mannose metabolism, thereby inhibiting succinate-mediated HIF-1α activation and IL-1β production.

Atractylodes lancea (Thunb.) DC. is a Chinese herb that has been commonly used to treat spleen-deficiency diarrhea (SDD) in China for over a thousand years. However, the underlying mechanism of its antidiarrheal activity is not fully understood.The antidiarrheal effects of the ethanol extract of deep-fried A. lancea rhizome (EEDAR) due to spleen deficiency induced by folium sennae (SE) were determined on the regulation of the short-chain fatty acid (SCFA) metabonomics induced by the intestinal flora.The effects of EEDAR on a SE-induced mouse model of SDD were evaluated by monitoring the animal weight, fecal water content, diarrhea-grade rating, goblet cell loss, and pathological changes in the colon. The expression of inflammatory factors (tumor necrosis factor [TNF]-α, interleukin [IL]-1β, IL-6, IL-10), aquaporins (AQP3, AQP4, and AQP8), and tight junction markers (ZO-1, occludin, claudin-1) in colon tissues were determined using quantitative polymerase chain reaction and western blotting. SCFA metabonomics in the feces of mice treated with EEDAR was evaluated using gas chromatography-mass spectrometry. Furthermore, 16S rDNA sequencing was used to determine the effect of EEDAR on the intestinal flora of SDD mice, and fecal microbiota transplantation (FMT) was used to confirm whether the intestinal flora was essential for the anti-SDD effect of EEDAR.Treatment with EEDAR significantly improved the symptoms of mice with SDD by inhibiting the loss of colonic cup cells, alleviating colitis, and promoting the expression of AQPs and tight junction markers. More importantly, the effect of EEDAR on the increase of SCFA content in mice with SDD was closely related to the gut microbiota composition. EEDAR intervention did not significantly improve intestinal inflammation or the barrier of germ-free SDD mice, but FMT was effective.EEDAR alleviated SE-induced SDD in mice, as well as the induced SCFA disorder by regulating the imbalance of the intestinal microbiota.

The reliable and lightweight deployable solar arrays require the capability of large deformation for packaging and the ability to actively deform for deployment. To satisfy such demands, the shape memory polymer solar cells (SMPSCs) are fabricated and demonstrated in this paper by using flexible and conductive silver nanowire/shape memory copolyamide (AgNW/SMPI) composite film as the transparent substrates. The AgNW/SMPI composite film has good optical transparency (~73% at the wavelength of 450 ~ 1100 nm), smooth surfaces (average RMS: ~3.32 nm), good shape memory performances (shape fixation ratio > 98%, shape recovery ratio > 98%), and can maintain excellent conductivity (~10Ω/□) after mechanical deformations with large strain. Owing to the shape memory effect of the substrate, SMPSCs can be deformed into arbitrary shape and actively recover to the original shape upon heating. The power conversion efficiency of SMPSC (2.94%) is lower than that of ITO-based solar cells with the same structure (3.44%), due to the relatively lower optical transparency of SMPI. However, SMPSCs can maintain good photovoltaic performances after 50 bending-recovery cycles or few shape recovery cycles, demonstrating better flexibility and durability than ITO-based solar cells. The SMPSCs have the potential to be used in deployable solar arrays, and the transparent conductive SMPI film electrodes have the potential to be used in areas of sensors, medical probes, and displays.

Based on our previous successful material-level verification of a shape-memory polymer composite (SMPC) on the SJ-17 geostationary satellite on a geostationary orbit since November 2016, a structur...

Shape memory polymers (SMPs) are the simplest and most attractive alternatives for soft substrates of typical bilayer wrinkle systems because of shape fixity and recovery capabilities. Herein, we have successfully programmed large compressive strains in chemical cross-linking shape memory polystyrene (PS) microparticles via nanoimprint lithography, which acted as the substrate of a wrinkle system using a gold nanoparticle (Au NP) film as the top layer. When triggered by two different stimuli (direct heating and toluene vapors), the thin Au NP film could transform into various wrinkle structures atop the recovered PS particles. In addition, we also investigated the evolution mechanisms of wrinkling by heating and toluene vapors and tuned the wrinkled surfaces through altering the Au NP thickness and stimulation methods (direct heating and toluene vapors), which utilized the structural adjustability of Au NPs to program the amplitude, wavelength, and morphology of the wrinkles. The concept presented here provides a cost-effective approach to realize the surface wrinkling and can be extended to other available SMPs.

Camellia gigantocarpa Hu et T. C. Huang, belonging to the Theaceae family, is an excellent landscape tree species with high ornamental value. It is also an important woody oil-bearing plant with high economic value. This study reports the first complete chloroplast genome sequence of C. gigantocarpa (GenBank accession number: MZ054232). Its whole chloroplast genome is 156,953 bp long with an overall GC content of 37.31%, which is composed of a large single copy region (86,631 bp), a small single copy region (18,402 bp), and a pair of inverted repeat regions (25,960 bp each). A total of 135 genes were predicted in this genome, namely eight ribosomal RNA genes, 37 transfer RNA genes, and 90 protein-coding genes. Based on maximum likelihood analysis results, we found that the Camellia species are clustered into a distinct branch, and the phylogenetic relationships among C. gigantocarpa, C. crapnelliana, and C. kissii were the closest.

Exosome is an emerging tumor marker, whose concentration level can reflect the occurrence and development of tumors. The development of rapid and sensitive exosome detection platform is of great significance for early warning of cancer occurrence. Here, a strategy for electrochemical detection of A549-cell-derived exosomes was established based on DNA/ferrocene-modified single-walled carbon nanotube complex (DNA/SWCNT-Fc). DNA/SWCNT-Fc complexes function as a signal amplification platform to promote electron transfer between electrochemical signal molecules and electrodes, thereby improving sensitivity. At the same time, the exosomes can be attached to DNA/SWCNT-Fc nanocomposites via the established PO

Currently, the implants used for enophthalmic invagination have the disadvantages of precise filling difficulty, weak filling ability, large surgical wounds, and lack of CT development. Here, a CT-developable orbital stent was manufactured via 4D printing of a shape memory polyurethane composite for enophthalmos treatment. The composite was endowed with good CT development properties via incorporation of gold nanoparticles and nano-hydroxyapatite. Based on the bionic idea and CT reconstruction technique, a 4D printed orbital stent with a bionic honeycomb pore structure and an outer contour matching the orbital coloboma was designed to support the orbital tissue more accurately and stably. CT images of rabbits before and after the 4D printed orbital stent implantation showed better volume-filling capacity compared with the two types of the commercial orbital implants. The three-month follow-up showed the good postoperative result, which demonstrated the excellent performance of the composite in the precise minimally invasive treatment of enophthalmos compared with traditional orbital implants.

Acute lung injury (ALI) is one of the representative “lung heat syndromes” in traditional Chinese medicine (TCM). Scutellaria baicalensis is an herbal medicine used in TCM for treating lung diseases, due to its remarkable anti-inflammatory and antiviral effects. When used in TCM, S. baicalensis root is divided into two categories: S. baicalensis pith-not-decayed root (SN) and S. baicalensis pith-decayed root (SD). Compared to SN, SD has a better effect on lung diseases. We constructed a lipopolysaccharide (LPS)-induced acute lung injury (ALI) mouse model to study the pharmacodynamic mechanism of SD. The ethanolic extract of Scutellaria baicalensis pith-decayed root (EESD) significantly affected LPS-induced ALI by reducing alveolar interstitial thickening, pulmonary edema, and other pathological symptoms, decreasing the infiltration of inflammatory cells, especially macrophages, and inhibiting IL-1β, TNF-α, and IL-6 transcription and translation. Furthermore, in the THP-1 macrophage model induced by LPS, EESD inhibited the expression of phosphorylated nuclear factor inhibitory protein alpha (p-IκBα), phosphorylated nuclear factor-κB P65 (p-p65), cleaved-caspase-1, cleaved-IL-1β protein, and the release of inflammatory factors in the NF-κB/NLRP3 pathway, inhibiting macrophage function. In vivo experiments yielded similar results. Therefore, the present study clarified the potential of EESD in the treatment of ALI and revealed its potential pharmacodynamic mechanism by inhibiting the NF-κB/NLRP3 inflammasome pathway and suppressing the pro-inflammatory phenotype activation of lung tissue macrophages.

Arsenic (As), cadmium (Cd), and copper (Cu) are the primary inorganic pollutants commonly found in contaminated soils. The simultaneous stabilization of the three elements is a preferred approach for mixture-contaminated soils which has received extensive research attention. However, few studies have focused on the immobilization efficiency of a single amendment on the three elements. In this study, phosphate, red mud, and biochar were used to remediate As (237.8 mg kg−1), Cd (28.72 mg kg−1), and Cu (366.5 mg kg−1) co-contaminated soil using a 180-day incubation study. The BCR (European Community Bureau of Reference) extraction method, NH4H2PO4–extractable As, and diethylenetriamine penta-acetic acid (DTPA)–extractable Cd and Cu were analyzed at different time intervals. The results indicated that the application of red mud and biochar significantly reduced soil DTPA–Cd and Cu concentrations during the incubation, while the decrease in soil NH4H2PO4–As was much less than that of soil DTPA–Cd and Cu. After 180 days of incubation, the concentrations of NH4H2PO4–As in red mud and biochar treatments decreased by 2.15~7.89% and 3.01~9.63%, respectively. Unlike red mud and biochar, phosphate significantly reduced the concentration of soil DTPA–Cd and Cu, but failed to lower that of As. The BCR extraction method confirmed that red mud and biochar addition increased the reducible fraction of As due to the surface complexes of As with Fe oxide. Canonical correspondence analysis (CCA) demonstrated that soil pH in addition to available As, Cd, and Cu concentrations were the primary factors in driving the changes in soil enzymatic activity. Soil pH showed positive correlation with soil urease and catalase activities, while negative correlation was observed between soil-available As, Cd, and Cu, and soil enzyme activities. This study revealed that it is difficult to simultaneously and significantly reduce the bioavailabilities of soil As, Cd, and Cu using one amendment. Further research on modifying these amendments or applying combined amendments will be conducted, in order to develop an efficient method for simultaneously immobilizing As, Cd, and Cu.

Perfluorohexanesulfonic acid (PFHxS) is one of the persistent organic pollutants that has been recommended to be listed in Annex A of the Stockholm Convention. It has gained increasing attention in recent years due to its toxic effects. The guideline values of PFHxS are commonly associated with PFOS in various countries and regulatory agencies. In this study, multispecies bioassays were conducted to determine the ecological toxic effects of PFHxS, including plants, soil invertebrates, and soil microorganisms, which indicated the EC10/NOEC values ranged from 2.9 to 250 mg/kg. Where possible, logistic models were used to calculate the EC30 values for various endpoints. The species sensitivity distributions were employed to estimate the ecological investigation levels for PFHxS contamination in soils using toxicity results from literature and this study. The calculation using EC10/NOEC values from both literature and this study indicated a most conservative HC5 as 1.0 mg/kg (hazardous concentration for 5 % of the species being impacted). However, utilisation of EC30 values derived from this study resulted in a much higher HC5 for PFHxS in contaminated soils (13.0 mg/kg) which is at the higher end of the existing guideline values for PFOS for protecting ecological systems. The results obtained in this study can be useful in risk assessment processes to minimize any uncertainty using combined values with PFOS.

In this work, a novel fluorescent biosensor for sensitive detecting of aflatoxin B

High-performance shape memory thermosetting polymers and their composites for four-dimensional (4D) printing are essential in practical applications. To date, most printable thermosets suffer from complicated processes, poor thermodynamic performances, and low printing speed. Here, photosensitive composite inks for fast photocuring printing are developed. The inks consist of epoxy acrylate (EPAc), polyethylene glycol dimethacrylate (PEGDMA), and carbon fillers, which form a firm network structure when exposed to UV light. EPAc is synthesized via addition esterification of epoxy resin and acrylic acid under mild conditions. It is worth noting that raw materials for the reaction are diverse, including not only various epoxy resins but also molecules with epoxy groups. The 4D printing speed of up to 180 mm/h is mainly attributed to the exothermic reaction initiated by free radicals, which accelerates the polymerization of EPAc and PEGDMA. Most importantly, by increasing the exposure time of each layer from 1 s to 3 s during the printing process, the epoxy composite-infilled carbon nanotubes and carbon fibers are printed to ensure the integrity of the microlayer structure. Furthermore, we design a claw-like catcher device based on the above printable composite inks to demonstrate its potential applications in aerospace, such as grasping end-of-service spacecraft or explosive debris. Undoubtedly, 4D printing technology opens up a new portal for the manufacturing of thermoset epoxy composites and complex structures, which make the shape memory thermosetting epoxy resins and their composites possess excellent properties and good engineering application prospects.

Shape memory polymer (SMP) is a kind of material that can sense and respond to the changes of the external environment, and its behavior is similar to the intelligent reflection of life. Electrospinning, as a versatile and feasible technique, has been used to prepare shape memory polymer fibers (SMPFs) and expand their structures. SMPFs show some advanced features and functions in many fields. In this review, we give a comprehensive overview of SMPFs, including materials, fabrication methods, structures, multifunction, and applications. Firstly, the mechanism and characteristics of SMP are introduced. We then discuss the electrospinning method to form various microstructures, like non-woven fibers, core/shell fibers, hollow fibers and oriented fibers. Afterward, the multiple functions of SMPFs are discussed, such as multi-shape memory effect, reversible shape memory effect and remote actuation of composites. We also focus on some typical applications of SMPFs, including biomedical scaffolds, drug carriers, self-healing, smart textiles and sensors, as well as energy harvesting devices. At the end, the challenges and future development directions of SMPFs are proposed.

PM2.5 and its main chemical components have been investigated during six air pollution periods across four seasons from Jun. 16, 2016 to Jun. 15, 2017 at a suburban site in Beijing, China. Daily PM2.5 mass concentrations were measured with associated ions, OC, EC, 16 PAHs and seven heavy metals. Mass closure analyses were conducted using measured and reconstructed chemical components. Chemical ratios were used to identify possible pollution sources, while principal component analysis (PCA) coupled with multiple linear regression (MLR) method was used to estimate the source contribution to PM2.5 mass. The annual mean PM2.5 concentration (96.7 μg m−3) is about 2.8 times the national level-2 standard limit, with apparent seasonal variation of daily exceedances as winter > spring > autumn > summer. Generally, higher levels are observed in winter and autumn than in spring and summer for NO3−, SO42−, NH4+, Cl−, K+, OC, EC, PAHs and metals Zn, As, Cu, Pb, along with higher concentrations of NOx, CO and SO2. Secondary ions and carbon fractions are most abundant over all seasons, except levels of dust related species Ca2+, Mg2+, Ca, Fe and Mn are also high in spring. The reconstructed results show that PM2.5 consists of mostly organic compounds (26–38%) and ammonium salts (NH4NO3 + (NH4)2SO4) (43–53%) in winter and autumn, while summer is dominated mainly by ammonium salts (81%). In spring, very high PM2.5 episodes are occasionally composed of large amount of soil/road dust and gypsum particles (23–55%) due to floating dust events with drier weather conditions and human activities. Fuel combustions and secondary sources are responsible for ~70% of PM2.5 mass while mobile source is mostly a regional origin.

This study aims to investigate the dynamic changes over time in the immobilization efficiency of hydroxyapatite, bentonite, and biochar for Cd and Pb co-contaminated soil given the potential remobilization of immobilized heavy metals for long-term stabilized soils. Hydroxyapatite, bentonite, and biochar were applied only once at 2.5% (w/w) of soil during a 5-year pot experiment with pepper-cabbage (Capsicum annuum L.-Brassica pekinensis) rotation. The dynamic changes of soil pH, soil organic carbon (SOC), TCLP (toxicity characteristic leaching procedure)-, DTPA-, and PBET (simulated human gastric solution extraction)-Cd and Pb in soil, fractionation of Cd and Pb in soil, as well as the dynamic variations of bioaccessible Cd and Pb in vegetables were determined. The results indicated the application of hydroxyapatite, bentonite, and biochar significantly increased the proportion of residual fraction of Cd and Pb, and reduced the mobility, bioavailability, and bioaccessibility of Cd and Pb analyzed by TCLP, DTPA, and PBET, respectively. Moreover, the concentrations of TCLP-, DTPA-, and PBET-Cd and Pb gradually increased over time. The proportions of acid-extractable Cd and Pb in amended treatments in 2019 were higher than those in 2016. The increment for acid-extractable Cd fraction was 4.69%, 5.53%, and 4.19% in hydroxyapatite, bentonite, and biochar, respectively. While the increment for acid-extractable Pb fraction was 1.48%, 2.08%, and 1.91%, respectively. The bioaccessible Cd and Pb in pepper and cabbage significantly decreased after remediation while no remarkable changes were observed for Pb from 2017 to 2019. The three amendments were effective ameliorants for Cd and Pb co-contaminated acidic soil, but the immobilization efficiency decreased over time. Moreover, hydroxyapatite showed the highest efficiency on metal stabilization and vegetable safety.