148 results on '"Zhao, Zhen-Gang"'
Search Results
102. The CYP2C19 genotype does not impact the long-term prognosis of patients with coronary artery disease
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Peng, Yong, primary, Chen, Mao, additional, Liu, Xiao-jing, additional, Liu, Wei, additional, Li, Qiao, additional, Chai, Hua, additional, Ren, Xin, additional, Wang, Xue-qin, additional, Zhao, Zhen-gang, additional, Zhang, Chen, additional, Luo, Xiao-lin, additional, and Huang, De-jia, additional
- Published
- 2013
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103. Application of Cole‐Cole plot to study contact resistance of CNTs humidity sensor
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Zhao, Zhen‐Gang, primary and Li, Chuan, additional
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- 2013
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104. FBG Strain Sensor for Monitoring Daily Wind Direction Change on Power Tower Cross Arm Deformation Effects
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Xue, Zhen Li, primary, Chen, Xiao Yong, additional, Cai, Zhou Chun, additional, Li, Chuan, additional, and Zhao, Zhen Gang, additional
- Published
- 2013
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105. GW24-e1746 Transcatheter aortic valve implantation in high-risk patients with severe bicuspid aortic valve stenosis: Feasibility, safety and efficacy
- Author
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Chen Mao, Huang De-jia, Zhao Zhen-gang, Wei Xin, Tang Hong, Xu Yuan-ning, and Feng Yuan
- Subjects
medicine.medical_specialty ,business.industry ,Periprosthetic ,Hemodynamics ,Regurgitation (circulation) ,medicine.disease ,Surgery ,Stenosis ,Bicuspid aortic valve ,Aortic valve replacement ,Internal medicine ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,Contraindication ,Survival rate - Abstract
Objectives We sought to assess the feasibility and outcomes of transcatheter aortic valve implantation (TAVI) in the setting of bicuspid aortic valves (BAVs), which were regarded as a relative contraindication. Methods Consecutive patients with severe BAV stenosis, who underwent TAVI at West China Hospital between April 2012 and March 2013, were included for analysis. Their procedural, hemodynamic and clinical outcomes were presented according to the standardised definitions of the Valvular Academic Research Consortium-2 (VARC-2). Results A total of 12 patients (mean age, 73 years; 9 men and 3 women) with symptomatic BAV stenosis were identified. All patients were deemed unsuitable for conventional aortic valve replacement due to high perceived surgical risk, as was testified by the mean logistic EuroSCORE of 36.1%. TAVI was performed through a transfemoral and transsubclavian access in 11 and 1 patient, respectively. The Medtronic CoreValve was successfully implanted for all patients with the exception of one, in whom the prosthetic valve failed to expand properly due to the heavily calcified native leaflets and was retracted safely without adverse effects. There was no intraprocedural or periprocedural (within 72 hours following TAVI) death. Striking hemodynamic improvements were observed after TAVI. The mean (± standard deviation) aortic-valve gradient reduced from 57.7 ± 9.3 mmHg to 13.1 ± 5.4 mmHg, and the peak jet velocity decreased from 4.8 ± 0.5 m/s to 2.3 ± 0.6 m/s. Marginal moderate periprosthetic regurgitation occurred in 1 patient. Using the VARC-2 definition, the device success rate was 83.3% (10 of 12). Permanent pacemakers were implanted in 4 patients (33.3%) owing to third-degree atrioventricular blocks. One patient was attacked by ischaemic stroke 4 days after TAVI, but recovered without significant neurological sequelae at discharge. Another patient suffered from minor vascular complication (or minor bleeding) and died suddenly 20 days after TAVI. Afterwards, no further death was observed. Thus the survival rate was 91.7% at 30 days and remained unchanged at a median follow-up over 200 days to date. Conclusions TAVI using the CoreValve is feasible, safe and associated with satisfactory mid-term clinical outcomes in selected high-risk patients with severely stenotic BAVs, but the long-term outcomes remain to be evaluated.
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- 2013
106. Using strong acid–cation exchange resin to reduce potassium level in molasses vinasses
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Zhang, Ping-Jun, primary, Zhao, Zhen-Gang, additional, Yu, Shu-Juan, additional, Guan, Yong-Guang, additional, Li, Dan, additional, and He, Xiang, additional
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- 2012
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107. Composite Content Influence on Multiwall Carbon Nanotubes-SiO2 Film Humidity Sensors at AC Testing
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Li, Tuo, primary, Liu, Xiao Wei, additional, and Zhao, Zhen Gang, additional
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- 2012
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108. Degradation of N-(1-Deoxy-d-xylulos-1-yl)glycine and N-(1-Deoxy-d-xylulos-1-yl)proline using thermal treatment
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Zhang, Ping-Jun, primary, Zhao, Zhen-Gang, additional, Yu, Shu-Juan, additional, and He, Shu-Zhen, additional
- Published
- 2011
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109. Cathodic Polarization Behavior and Deposit Structure of Jet Electrodeposition Nickel
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Yang, Jun, primary, Qiao, Gui Ying, additional, Liu, Wen Xin, additional, Chen, Xue Lian, additional, and Zhao, Zhen Gang, additional
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- 2011
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110. Carbon nanotube sensors based on 555 multivibrators
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ZHAO Zhen-gang, 赵振刚, primary, LIU Xiao-wei, 刘晓为, additional, WANG Xin, 王鑫, additional, JIN Hai-yan, 金海燕, additional, and TAN Xiao-yun, 谭晓昀, additional
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- 2011
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111. Poly[[di-μ3-nicotinato-μ3-oxalato-samarium(III)silver(I)] dihydrate]. Corrigendum
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Zhu, Li-Cai, primary, Zhao, Zhen-Gang, additional, and Yu, Shu-Juan, additional
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- 2010
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112. A Capacitive Humidity Sensor Based on Multi-Wall Carbon Nanotubes (MWCNTs)
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Chen, Wei-Ping, primary, Zhao, Zhen-Gang, additional, Liu, Xiao-Wei, additional, Zhang, Zhong-Xin, additional, and Suo, Chun-Guang, additional
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- 2009
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113. Poly[[di-μ3-nicotinato-μ3-oxalato-samarium(III)silver(I)] dihydrate]
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Zhu, Li-Cai, primary, Zhao, Zhen-Gang, additional, and Yu, Shu-Juan, additional
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- 2009
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114. Analysis of Temperature Effects on a Fully-Symmetrical Micromachined Gyroscope
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Chen, Wei Ping, primary, Guo, Yu Gang, additional, Chen, Xiao Liang, additional, Chen, Hong, additional, and Zhao, Zhen Gang, additional
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- 2009
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115. Causes and clinical outcomes of acute-on-chronic liver failure in patients with hepatitis B virus infection: an analysis of 289 cases
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Zhao, Zhen-Gang, primary, Han, Tao, additional, Gao, Ying-Tang, additional, Gao, Yan-Ying, additional, Zhang, Ye, additional, and Wu, Zhen-Ping, additional
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- 2009
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116. 2-Hydroxy-1,6,7,8-tetramethoxy-3-methylanthraquinone
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Zhu, Li-Cai, primary, Zhao, Zhen-Gang, additional, and Yu, Shu-Juan, additional
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- 2008
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117. Geochemistry, Geochronology and Geological Implication of Intrusive Rock from Beizhan Iron Deposit of Xinjiang.
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ZHENG Yong, HUANG Wen-hai, ZHOU Yi, ZHAO Zhen-gang, GUO Xin-cheng, and CHEN Zheng-hui
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Beizhan iron deposit in Xinjiang is one of the important deposits of Awulale iron-copper-gold metallogenic belt in the western Tianshan. K-feldspar granite and K-feldspar granite porphyry, which have pulsating intrusive contact relationship, are exposed in the southern of iron district. Geochemical characteristics show that the rocks are high potassium calc-alkaline, enriched in large iron lithophile element (Rb and K), and relatively depleted in high field strength elements, and Ba, Sr, P and Ti are significantly negative anomaly; fractionation of light and heavy rare earth elements is obvious. Ages of K-feldspar granite and K-feldspar granite porphyry from Beizhan iron deposit are respectively (320.5±1.9) Ma and (306.8±1.6) Ma by the method of LA-ICP-MS zircon U-Pb dating. Combined with regional geological data, the geochemical and geochronological results show that K-feldpar granite and K-feldspar granite porphyry exposed have the same magma source, and probably form in the tectonic setting transformed from the subduction of southern Tianshan oceans to the continental collision orogeny from Early Carboniferous to Late Carboniferous. [ABSTRACT FROM AUTHOR]
- Published
- 2014
118. Transcatheter aortic valve implantation in bicuspid anatomy
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Zhao, Zhen-Gang, Jilaihawi, Hasan, Feng, Yuan, and Chen, Mao
- Abstract
Transcatheter aortic valve implantation (TAVI) is an established therapeutic option for high-risk patients with a tricuspid aortic valve, but patients with a bicuspid aortic valve (BAV) are contraindicated. In this Perspectives article, Zhao and colleagues summarize the available evidence for the use of TAVI in patients with a BAV and propose that this procedure might be appropriate in high-risk or inoperable individuals, but that more evidence is required before indications for TAVI can be extended to other patients with a BAV.
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- 2015
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119. Composite Content Influence on Multiwall Carbon Nanotubes-SiO2 Film Humidity Sensors at AC Testing
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Li, Tuo, Liu, Xiao Wei, and Zhao, Zhen Gang
- Abstract
MWNT –SiO2 composite film humidity sensors with different MWNTs proportions were fabricated and their performances under alternating current testing signals are investigated. Influence of MWNT content on humidity sensing characteristics of the sensors is explored and explained by vapor adsorption and capillary condensation effect. It is proved that 60% MWNT content sensors have humidity sensitivity of 1500% at 400 kHz testing frequency, much higher than those with other MWNT contents. In sensors’ sensitivity-frequency relation, maximum sensitivity comes from frequency section of 400kHz to 500kHz for sensors with higher MWNTs proportions.
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- 2013
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120. Abstract 14893: Obesity and Heart-Healthy Dietary Choices in Severe Aortic Stenosis.
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Taylor, Zachary, Williams, Mathew, Zhao, Zhen-Gang, Du, Run, Staniloae, Cezar, Saric, Muhamed, Pushkar, Illya, Neuburger, Peter, Querijero, Michael, Vainrib, Alan, Hisamoto, Kazuhiro, Amoroso, Nicholas, Collins, Tara, Clark, Emily, Sin, Danielle, Shah, Binita, Lee, Hanah, Vidal, Samantha, Bamira, Daniel, and Benenstein, Ricardo
- Published
- 2018
121. First-in-man implantation of a pre-packaged self-expandable dry-tissue transcatheter aortic valve.
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Feng, Yuan, Zhao, Zhen-Gang, Baccaro, Jorge, Zeng, Min Frank, Fish, R David, and Chen, Mao
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- 2018
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122. Comparison of procedural, clinical and valve performance results of transcatheter aortic valve replacement in patients with bicuspid versus tricuspid aortic stenosis.
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Liao, Yan-biao, Li, Yi-jian, Xiong, Tian-yuan, Ou, Yuan-weixiang, Lv, Wen-yu, He, Jia-ling, Li, Yi-Ming, Zhao, Zhen-gang, Wei, Xin, Xu, Yuan-ning, Feng, Yuan, and Chen, Mao
- Subjects
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AORTIC stenosis , *MITRAL valve , *TRICUSPID valve , *CORONARY artery stenosis , *PATIENTS ,AORTIC valve surgery - Abstract
Background Limited date describing the procedural, clinical and valve performance results of transcatheter aortic valve replacement (TAVR) in patients with bicuspid versus tricuspid aortic stenosis (TAV). Methods Procedural and clinical results were defined and reported according to VARC-2 criteria. Results Consecutive 87 patients with BAV and 70 patients with TAV were included. Compared to patients with TAV, patients with BAV had similar incidence of second valve implantation (14.9% vs 12.9%, p = 0.708), more than mild paravalvular leakage (PVL, 40.2% vs 31.9%, p = 0.288), permanent pacemaker implantation (PPM, 24.1% vs 28.6%, p = 0.53). Furthermore, the procedural and clinical results of TAVR also did not differ between patients with type 0 and type 1 (second valve implantation: 18.4% vs 11.8%, p = 0.71, PVL: 38.8% vs 41.2%, p = 0.83, PPM: 18.4% vs 31.6%, p = 0.16). The hemodynamic outcomes were similar in patients with BAV and TAV at 1-year (maximum velocity, 2.3 vs 2.2 m/s, p = 0.307) and 2-year (2.3 vs 2.1 m/s, p = 0.184) follow-up respectively. Adjusted binary logistic regression analysis found oversizing ratio at 14.45–20.57% is at lower risk for more than mild PVL (OR, 0.069, 95% CI, 0.011–0.428, p = 0.004). Moreover, the Kaplan–Meier survival analysis revealed that TAVR in type 0 BAV, type 1 BAV and TAV have comparable risk for midterm mortality (Log rank, p = 0.772). Conclusion TAVR in whatever type of BAV appeared to be safe and efficacy, and TAVR in BAV was associated with comparable bioprosthetic function during follow up compared to patients with TAV. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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123. Development and characterization of novel chitosan emulsion films via pickering emulsions incorporation approach.
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Shi, Wei-Jian, Tang, Chuan-He, Yin, Shou-Wei, Yin, Yan, Yang, Xiao-Quan, Wu, Lei-Yan, and Zhao, Zhen-Gang
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CHITOSAN , *EMULSIONS , *WATER vapor , *MICROSTRUCTURE , *PERMEABILITY , *CRYSTAL morphology - Abstract
Microstructure heterogeneity of emulsion films impaired their physical performances. This work attempted to fabricate novel high-barrier chitosan (CH) emulsion films by manipulating emulsion's interface architecture via Pickering stabilization approach. Some selected physical properties, including tensile property, water vapor permeability (WVP), and oxygen permeability (OP) as well as the microstructure of the films were evaluated. Film-forming emulsions (FFEs) based on zein/chitosan colloid particles-stabilized Pickering emulsions (ZCCPEs) were extremely stable, evidenced by the similar droplets size and size distribution in the FFEs and film matrix, endowing the films with homogeneous distributions of lipid droplets over their 3D network matrix. Interestingly, emulsion films exhibited excellent oxygen-barrier efficiency, and the OP of the films was decreased by 1−4 orders of magnitude when compared with CH films. This phenomenon may be associated with the novel interfacial architecture of ZCCPEs as well as film microstructure morphology based on ordered assembles of CH matrix and ZCCPEs. A schematic diagram for the formation pathway of ZCCPEs-loaded CH emulsion films was proposed to establish structure-function relationships of the films. This study opens a promising pathway for producing emulsion films with excellent oxygen-barrier capability via Pickering stabilization principle. [ABSTRACT FROM AUTHOR]
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- 2016
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124. The triglyceride paradox in the mortality of coronary artery disease.
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Xia, Tian-li, Huang, Fang-yang, Chai, Hua, Huang, Bao-tao, Li, Qiao, Zhao, Zhen-gang, Liao, Yan-biao, Zuo, Zhi-liang, Peng, Yong, Chen, Mao, Huang, De-jia, and Li, Yi-ming
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CORONARY disease , *PROGNOSIS , *HYPERTRIGLYCERIDEMIA , *MORTALITY , *CLINICAL trials - Abstract
Background: The role of triglyceride (TG) in secondary prevention of patients with coronary artery disease (CAD) was debated. In the present study, we assessed the association between admission TG levels and long-term mortality risk in CAD patients. Methods: A retrospective analysis was conducted from a single registered database. 3061 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into 3 categories by the tertiles of admission serum TG levels. The primary end point in this study was all-cause mortality and the secondary end point was cardiovascular mortality. Results: The mean follow-up time was 26.9 ± 13.6 months and death events occurred in 258 cases and cardiovascular death events occurred in 146 cases. Cumulative survival curves indicated that the risk of all-cause death decreased with increasing TG level (Tertile 1 vs. Tertile 2 vs. Tertile 3 = 10.3% vs. 8.6% vs. 6.3%, log rank test for overall p = 0.001). Cox regression analysis showed an independent correlation between TG level and risk of all-cause mortality [hazard ratio (HR) 0.71, 95% confidence interval (CI) 0.58–0.86] and cardiovascular mortality (HR 0.67, 95% CI 0.51–0.89) in total patients with CAD. Subgroup analysis found the similar results in patients with acute coronary syndrome and acute myocardial infarction. Conclusions: This study found an inverse association between TG levels and mortality risk in CAD patients, which suggests that the "TG paradox" may exist in CAD patients. Trial registration: ChiCTR, ChiCTR-OOC-17010433. Registered 17 February 2017 - Retrospectively registered. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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125. Recurrent strokes in a 64-year-old woman caused by left ventricular diverticulum.
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Qiao XC, Yan MY, and Zhao ZG
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- Humans, Female, Middle Aged, Stroke diagnostic imaging, Stroke etiology, Echocardiography, Heart Diseases diagnostic imaging, Treatment Outcome, Diverticulum diagnostic imaging, Diverticulum complications, Heart Ventricles diagnostic imaging, Recurrence
- Abstract
Competing Interests: Conflict of interest: None declared.
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- 2024
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126. Fatty acid binding protein 5 is a novel therapeutic target for hepatocellular carcinoma.
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Li Y, Lee W, Zhao ZG, Liu Y, Cui H, and Wang HY
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Background: Hepatocellular carcinoma (HCC) is an aggressive subtype of liver cancer and is one of the most common cancers with high mortality worldwide. Reprogrammed lipid metabolism plays crucial roles in HCC cancer cell survival, growth, and evolution. Emerging evidence suggests the importance of fatty acid binding proteins (FABPs) in contribution to cancer progression and metastasis; however, how these FABPs are dysregulated in cancer cells, especially in HCC, and the roles of FABPs in cancer progression have not been well defined., Aim: To understand the genetic alterations and expression of FABPs and their associated cancer hallmarks and oncogenes in contributing to cancer malignancies., Methods: We used The Cancer Genome Atlas datasets of pan cancer and liver hepatocellular carcinoma (LIHC) as well as patient cohorts with other cancer types in this study. We investigated genetic alterations of FABPs in various cancer types. mRNA expression was used to determine if FABPs are abnormally expressed in tumor tissues compared to non-tumor controls and to investigate whether their expression correlates with patient clinical outcome, enriched cancer hallmarks and oncogenes previously reported for patients with HCC. We determined the protein levels of FABP5 and its correlated genes in two HCC cell lines and assessed the potential of FABP5 inhibition in treating HCC cells., Results: We discovered that a gene cluster including five FABP family members ( FABP4, FABP5, FABP8, FABP9 and FABP12 ) is frequently co-amplified in cancer. Amplification, in fact, is the most common genetic alteration for FABPs, leading to overexpression of FABPs. FABP5 showed the greatest differential mRNA expression comparing tumor with non-tumor tissues. High FABP5 expression correlates well with worse patient outcomes ( P < 0.05). FABP5 expression highly correlates with enrichment of G2M checkpoint ( r = 0.33, P = 1.1e-10), TP53 signaling pathway ( r = 0.22, P = 1.7e-5) and many genes in the gene sets such as CDK1 ( r = 0.56, P = 0), CDK4 ( r = 0.49, P = 0), and TP53 ( r = 0.22, P = 1.6e-5). Furthermore, FABP5 also correlates well with two co-expressed oncogenes PLK1 and BIRC5 in pan cancer especially in LIHC patients ( r = 0.58, P = 0; r = 0.58, P = 0; respectively). FABP5
high Huh7 cells also expressed higher protein levels of p53, BIRC5, CDK1, CDK2, and CDK4 than FABP5low HepG2 cells. FABP5 inhibition more potently inhibited the tumor cell growth in Huh7 cells than in HepG2 cells., Conclusion: We discovered that FABP5 gene is frequently amplified in cancer, especially in HCC, leading to its significant elevated expression in HCC. Its high expression correlates well with worse patient outcome, enriched cancer hallmarks and oncogenes in HCC. FABP5 inhibition impaired the cell viability of FABP5high Huh7 cells. All these support that FABP5 is a novel therapeutic target for treating FABP5high HCC., Competing Interests: Conflict-of-interest statement: All authors have seen and agreed with the contents of the manuscript and there is no conflict of interest to declare., (©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.)- Published
- 2024
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127. Optimal treatment of asymptomatic patients with severe aortic stenosis: protocol of a prospective, multicentre, registry study.
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Xia C, Li YM, Xiong W, Ma L, Xiong TY, Zhao ZG, Peng Y, Wei J, Feng Y, and Chen M
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- Humans, Multicenter Studies as Topic, Prospective Studies, Registries, Risk Factors, Treatment Outcome, Aortic Valve Stenosis surgery, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Introduction: Decisions regarding the optimal timing of intervention for asymptomatic aortic stenosis (AS) are controversial. The study aims to identify potential risk factors for asymptomatic patients with severe AS that are associated with worse prognosis and to evaluate the benefits of early interventions for asymptomatic patients presenting with one or more additional risk factors., Methods and Analysis: This is a non-interventional, prospective, open-label, multicentre registry study across China. A total of 1000 patients will be enrolled and categorised as symptomatic or asymptomatic. The primary endpoint is the occurrence of all-cause mortality, stroke, acute myocardial infarction and heart failure-related hospitalisation at 1-year follow-up. In asymptomatic severe AS patients presenting with one or more risk factors, the occurrence rate of the primary endpoint between those who undergo transcatheter aortic valve replacement (TAVR) and those who do not will be compared. We will also compare the occurrence rate of the primary endpoint for asymptomatic severe AS patients with additional risk factors who undergo TAVR with those presenting with symptoms. This study is believed to provide additional evidence to help clinicians identify and refer severe AS patients who are asymptomatic but present with additional risk factors for early intervention of TAVR., Ethics and Dissemination: The study protocol has been approved by the local ethics committee of each participating site: West China Hospital, Sichuan University; Sir Run Run Shaw Hospital, Zhejiang University School of Medicine; Second Hospital of Hebei Medical University; Tianjin Chest Hospital; and First Affiliated Hospital of Nanchang University. All participants will provide written informed consent. Study results will be published through academic conferences and peer-reviewed journals., Trial Registration: This study was registered at the Chinese Clinical Trial Registry (https:// www.chictr.org.cn), with the registration number ChiCTR2200064853., Competing Interests: Competing interests: Dr Chen and Feng are consultants and proctors for Venus MedTech, MicroPort and TaurusOne. All other authors have nothing relevant to disclosure., (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2023
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128. First-in-human experience with a novel transcatheter direct annuloplasty system for severe atrial functional mitral regurgitation.
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Zhu ZK, Zhao ZG, Zhang TC, Chen F, Wei X, Liang YJ, Feng Y, and Chen M
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- Humans, Mitral Valve diagnostic imaging, Mitral Valve surgery, Cardiac Catheterization, Treatment Outcome, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency surgery, Mitral Valve Annuloplasty, Heart Valve Prosthesis Implantation
- Published
- 2023
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129. Outcomes Following Transcatheter Aortic Valve Replacement for Aortic Stenosis in Patients With Type 0 Bicuspid, Type 1 Bicuspid, and Tricuspid Aortic Valves.
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He J, Xiong TY, Yao YJ, Peng Y, Wei JF, Zhao ZG, Chen G, Ou YW, Liu Q, Wang X, Zhu Z, Yang HR, Jia K, Mylotte D, Piazza N, Prendergast B, Feng Y, and Chen M
- Subjects
- Humans, Aortic Valve diagnostic imaging, Aortic Valve surgery, Prospective Studies, Retrospective Studies, Treatment Outcome, Transcatheter Aortic Valve Replacement adverse effects, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases surgery, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Aortic Valve Stenosis etiology, Stroke etiology, Stroke surgery
- Abstract
Background: Data concerning the outcomes of transcatheter aortic valve replacement in type 0 bicuspid aortic stenosis (AS) are scarce. The study aims to compare the outcomes of transcatheter aortic valve replacement for AS in patients with type 0 bicuspid, type 1 bicuspid, and tricuspid aortic valve anatomy., Methods: We enrolled consecutive patients undergoing transcatheter aortic valve replacement for severe AS between 2012 and 2022 in this single-center retrospective cohort study. The primary outcome was mortality, while secondary outcomes included in-hospital complications such as stroke and pacemaker implantation and transcatheter heart valve hemodynamic performance., Results: The number of patients with AS with type 0 bicuspid, type 1 bicuspid, and tricuspid aortic valve anatomy was 328, 302, and 642, respectively. Self-expanding transcatheter heart valves were used in the majority of patients (n=1160; 91.4%). In the matched population, differences in mortality (30 days: 4.2% versus 1.7% versus 1.7%, P
overall =0.522; 1 year: 10% versus 2.3% versus 6.2%, Poverall =0.099) and all stroke (30 days: 1.0% versus 0.9% versus 0.0%, Poverall =0.765; 1 year: 1.4% versus 1.6% versus 1.3%, Poverall =NS) were nonsignificant, and the incidence of overall in-hospital complications was comparable among groups. Ascending aortic diameter was the single predictor of 1-year mortality in type 0 bicuspid patients (hazard ratio, 1.59 [95% CI, 1.03-2.44]; P =0.035). The proportion of patients with a mean residual gradient ≥20 mm Hg was the highest in those with type 0 bicuspid anatomy, although the need for permanent pacemaker implantation was the lowest in this group., Conclusions: Major clinical outcomes of transcatheter aortic valve replacement for AS in patients with type 0 bicuspid, type 1 bicuspid, and tricuspid aortic valve anatomy are equivalent at short- and mid-term follow-up. These observations merit further exploration in prospective international registries and randomized controlled trials., Competing Interests: Disclosures M. Chen and Dr Feng are proctors/consultants of Venus MedTech, MicroPort, and Peijia Medical. Dr Mylotte is a proctor and consultant for Medtronic and Microport and a consultant for Boston Scientific. Dr Piazza is a consultant and proctor for Medtronic and Peijia Medical. Dr Prendergast has received institutional educational and research grants from Edwards Lifesciences and speaker/consultancy fees from Abbott, Anteris, Edwards Lifesciences, Medtronic, and Microport. The other authors report no conflicts.- Published
- 2023
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130. Pulmonary hypertension-related dynamic left ventricular outflow tract obstruction.
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Liu JN, Zhao ZG, and Luo FM
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- Humans, Echocardiography, Ventricular Outflow Obstruction, Left, Hypertension, Pulmonary complications, Hypertension, Pulmonary diagnostic imaging, Ventricular Outflow Obstruction diagnostic imaging, Ventricular Outflow Obstruction etiology
- Published
- 2023
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131. Electromagnetic field and cardiovascular diseases: A state-of-the-art review of diagnostic, therapeutic, and predictive values.
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Wang Y, Zhao ZG, Chai Z, Fang JC, and Chen M
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- Humans, Electromagnetic Fields, Cardiovascular Diseases diagnosis, Cardiovascular Diseases therapy, Hypertension, Coronary Artery Disease, Myocardial Ischemia
- Abstract
Despite encouraging advances in early diagnosis and treatment, cardiovascular diseases (CVDs) remained a leading cause of morbidity and mortality worldwide. Increasing evidence has shown that the electromagnetic field (EMF) influences many biological processes, which has attracted much attention for its potential therapeutic and diagnostic modalities in multiple diseases, such as musculoskeletal disorders and neurodegenerative diseases. Nonionizing EMF has been studied as a therapeutic or diagnostic tool in CVDs. In this review, we summarize the current literature ranging from in vitro to clinical studies focusing on the therapeutic potential (external EMF) and diagnostic potential (internal EMF generated from the heart) of EMF in CVDs. First, we provided an overview of the therapeutic potential of EMF and associated mechanisms in the context of CVDs, including cardiac arrhythmia, myocardial ischemia, atherosclerosis, and hypertension. Furthermore, we investigated the diagnostic and predictive value of magnetocardiography in CVDs. Finally, we discussed the critical steps necessary to translate this promising approach into clinical practice., (© 2023 Federation of American Societies for Experimental Biology.)
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- 2023
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132. Correlations between geomagnetic field and global occurrence of cardiovascular diseases: evidence from 204 territories in different latitude.
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Chai Z, Wang Y, Li YM, Zhao ZG, and Chen M
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- Humans, Glia Maturation Factor, Data Analysis, Economics, Medical, Factor Analysis, Statistical, Cardiovascular Diseases epidemiology
- Abstract
Background: The correlation between stable geomagnetic fields and unstable geomagnetic activities with mortality, incidence, and prevalence of cardiovascular diseases (CVDs) remains ambiguous., Method: To investigate the correlations between geomagnetic field (GMF) intensity and geomagnetic disturbance (GMD) and CVDs events in global, long-period scale, global and 204 countries and territories were included on the base of 2019 Global Burden of Disease study (GBD 2019). Data of GMF intensity, GMD frequency, CVDs events, weather and health economic indicators from 1996 to 2019 of included locations were collected. Linear regression and panel data modelling were conducted to identify the correlations between GMF intensity and CVDs events, multi-factor panel data analysis was also generated to adjust the effect of confounding factors., Results: For the average data during 1996-2019, linear regression model revealed consistent positive correlations between total GMF (tGMF) intensity and mortality of total CVDs [coef = 0.009, (0.006,0.011 95%CI)], whereas negative correlations were found between horizonal GMF (hGMF) intensity and total CVD mortality [coef = -0.010 (-0.013, -0.007 95%CI)]. When considering the time trend, panel data analysis still demonstrated positive correlation between tGMF and total CVDs mortality [coef = 0.009, (0.008,0.009 95%CI)]. Concurrently, the hGMF negatively correlated with total CVDs mortality [coef = -0.008, (-0.009, -0.007 95%CI)]. When the panel models were adjusted for confounding factors, no reverse of correlation tendency was found between tGMF, hGMF and CVDs events. In high-income territories, positive correlation was found between geomagnetic storm (GMS) frequency and mortality of total CVDs [coef = 14.007,(2.785, 25.229 95%CI)], however, this positive trend faded away gradually with the latitude decreasing from polar to equator., Conclusions: Stable and long-term horizontal component of GMF may be beneficial to cardiac health. Unstable and short-term GMF called GMD could be a hazard to cardiac health. Our results suggest the importance of regular GMF in maintaining cardio-health state and the adverse impacts of GMD on cardiac health., (© 2023. BioMed Central Ltd., part of Springer Nature.)
- Published
- 2023
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133. Snaring Self-Expanding Devices to Facilitate Transcatheter Aortic Valve Replacement in Patients with Complex Aortic Anatomies.
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Yao YJ, Zhao ZG, Wang X, Peng Y, Wei JF, He S, Li YJ, He JJ, Zhu ZK, Feng Y, and Chen M
- Abstract
The snare-assisted technique has been described to facilitate transcatheter aortic valve replacement (TAVR) delivery system advancement in complex aortic anatomies. However, the evidence is limited to case reports. To evaluate the safety profile of the snare-facilitated approach and its impact on self-expanding (SE) TAVR outcomes, we collected consecutive patients who underwent transfemoral SE-TAVR for aortic stenosis, using propensity score matching (PSM) separately in tricuspid and type-0 and type-1 bicuspid aortic valve morphology between the snare and non-snare groups. In 766 patients, despite the snare group having significantly larger annulus angulation and maximal ascending aortic diameter, both groups achieved comparable 30-day device success rates, regardless of first-generation or new-generation valve use. After PSM, the snare group had a significantly lower new permanent pacemaker implantation rate among 193 type-0 patients (3.3% vs. 18.3%, p = 0.01). The ipsilateral group used new-generation valves less frequently (23.0% vs. 75.4%, p < 0.001), but there were no significant inter-group differences in procedure-related events, except for a lower incidence of PVL ≥ mild in the ipsilateral group (14.9% vs. 32.3%, p = 0.01). In conclusion, the snare-assisted technique appears useful in SE-TAVR with angulated aortic root anatomy, and the benefits were comparable between ipsilateral and contralateral snare techniques.
- Published
- 2023
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134. Extremely severe quadricuspid pulmonary valve stenosis treated by percutaneous balloon valvuloplasty.
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Wei X, Zhao ZG, Zhong XM, and Feng Y
- Subjects
- Humans, Follow-Up Studies, Treatment Outcome, Balloon Valvuloplasty, Pulmonary Valve Stenosis diagnostic imaging, Pulmonary Valve Stenosis surgery, Cardiac Surgical Procedures, Pulmonary Valve diagnostic imaging, Pulmonary Valve surgery
- Abstract
Competing Interests: Conflict of interest: None declared.
- Published
- 2022
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135. Transcatheter mitral valve implantation in severely calcified rheumatic mitral stenosis without annular calcification.
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Zhao ZG, Chen F, Wei X, Feng Y, and Chen M
- Subjects
- Cardiac Catheterization, Humans, Mitral Valve diagnostic imaging, Mitral Valve surgery, Treatment Outcome, Calcinosis complications, Calcinosis diagnostic imaging, Calcinosis surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation, Mitral Valve Stenosis complications, Mitral Valve Stenosis diagnostic imaging, Mitral Valve Stenosis surgery
- Published
- 2022
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136. Treating patients with excessively large annuli with self-expanding transcatheter aortic valves: insights into supra-annular structures that anchor the prosthesis.
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Xiong TY, Liao YB, Li YJ, Chen F, Ou Y, Wang X, Wang ZJ, Li X, Zhao ZG, Meng W, Feng Y, and Chen M
- Subjects
- Aortic Valve diagnostic imaging, Aortic Valve surgery, Humans, Multidetector Computed Tomography, Prosthesis Design, Retrospective Studies, Treatment Outcome, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Transcatheter Aortic Valve Replacement
- Abstract
Background: Some patients referred for transcatheter aortic valve replacement (TAVR) have excessively large annuli (ELA) without device options according to current sizing charts. This retrospective study aims to summarize the presentation and outcomes of ELA patients receiving first-generation self-expanding valves., Methods: The TAVR database was reviewed in search for cases of self-expanding valves. Patients who had annuli exceeding the perimeter limit on the device sizing chart were referred to as the ELA group. Patients who had annuli within the range covered by the two largest sizes and received the corresponding valve size served as the control group (CG). Baseline, procedures, outcomes, and imaging characteristics on multislice computed tomography (MSCT), such as native anatomy and postimplant stent geometry, were compared., Results: A total of 28 patients were included in the ELA group and 82 in the CG. The patients in the ELA group were younger than those in the CG (72.5 ± 6.2 vs. 75.4 ± 5.8 years, P = 0.03). The median intended perimeter oversizing in relation to the annulus in the ELA group was much smaller than in the CG (-0.4 [-4.6, 4.1] % vs. 16.1 [11.7, 20.8] %, P < 0.01). The calcium burden in the aortic root was around 1.3-fold greater in the ELA group than the CG (756.0 [534.5, 1670.9] vs. 582.1 [310.3, 870.9] mm
3 , P = 0.01). The need for second valve implantation was higher in ELA (21.4% vs. 12.2%, P = 0.23) but no valve embolization was encountered. The 1‑year follow-up was comparable, including >mild paravalvular leak., Conclusion: Under cautious patient selection using MSCT, TAVR with self-expanding valves in patients with ELA appears feasible. Supra-annular structures likely provide the extra anchoring., (© 2020. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)- Published
- 2021
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137. Differences in metabolic profiles between bicuspid and tricuspid aortic stenosis in the setting of transcatheter aortic valve replacement.
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Xiong TY, Liu C, Liao YB, Zheng W, Li YJ, Li X, Ou Y, Wang ZJ, Wang X, Li CM, Zhao ZG, Feng Y, Liu XJ, and Chen M
- Subjects
- Aged, Aortic Valve physiopathology, Aortic Valve surgery, Aortic Valve Stenosis blood, Aortic Valve Stenosis etiology, Aortic Valve Stenosis physiopathology, Arachidonic Acid blood, Arginine blood, Bicuspid Aortic Valve Disease, Biomarkers blood, Female, Heart Valve Diseases blood, Heart Valve Diseases complications, Heart Valve Diseases physiopathology, Hemodynamics, Humans, Male, Proline blood, Prospective Studies, Recovery of Function, Treatment Outcome, Ventricular Function, Left, Ventricular Remodeling, Aortic Valve abnormalities, Aortic Valve Stenosis surgery, Energy Metabolism, Heart Valve Diseases surgery, Metabolomics, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Background: To explore why bicuspid aortic stenosis has certain clinical differences from the tricuspid morphology, we evaluated the metabolomics profile involved in bicuspid aortic valve (BAV) aortic stenosis prior to and after transcatheter aortic valve replacement (TAVR) in comparison with tricuspid aortic valve (TAV)., Methods: In this TAVR cohort with prospectively collected data, blood samples were obtained before TAVR valve deployment and at the 7th day after TAVR, which were then sent for liquid and gas chromatography-mass spectrometry detection. Besides comparisons between BAV and TAV, BAV patients were also divided in subgroups according to baseline hemodynamics (i.e. maximal transaortic velocity, V
max ) and post-procedural reverse left ventricular (LV) remodeling (i.e. the change in LV mass index from baseline, ∆LVMI) for further analysis. Metabolic differences between groups were identified by integrating univariate test, multivariate analysis and weighted correlation network analysis algorithm., Results: A total of 57 patients were enrolled including 33 BAV patients. The BAV group showed lower arginine and proline metabolism both before and post TAVR than TAV represented by decreased expression of L-Glutamine. In BAV subgroup analysis, patients with baseline Vmax > 5 m/s (n = 11) or the 4th quartile of change in ∆LVMI at one-year follow-up (i.e. poorly-recovered LV, n = 8) showed elevated arachidonic acid metabolism compared with Vmax < 4.5 m/s (n = 12) or the 1st quartile of ∆LVMI (i.e. well-recovered LV, n = 8) respectively., Conclusions: Difference in arginine and proline metabolism was identified between BAV and TAV in TAVR recipients. Elevated arachidonic acid metabolism may reflect more severe baseline hemodynamics and worse LV reserve remodeling after TAVR in BAV.- Published
- 2020
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138. Progression of the Ascending Aortic Diameter After Transcatheter Aortic Valve Implantation: Based on Computed Tomography Images.
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Lv WY, Zhao ZG, Li SJ, Li YJ, Liao YB, Ou YW, Feng Y, and Chen M
- Subjects
- Aged, Aortic Aneurysm, Thoracic etiology, Disease Progression, Female, Follow-Up Studies, Humans, Male, Retrospective Studies, Aorta, Thoracic diagnostic imaging, Aortic Aneurysm, Thoracic diagnosis, Aortic Valve Stenosis surgery, Multidetector Computed Tomography methods, Postoperative Complications, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Objectives: The natural history of ascending aortic diameter after transcatheter aortic valve implantation (TAVI) has not been investigated. Our aim was to determine the progression of ascending aortic diameter in patients undergoing TAVI., Methods: We retrospectively included 134 patients undergoing TAVI for aortic stenosis at our institution from June 2012 to November 2016, including 79 patients with bicuspid aortic valve (BAV) and 55 patients with tricuspid aortic valve (TAV). Preoperative measurements of the ascending aorta were compared with aortic measurements at 1-year follow-up based on computed tomography images., Results: A very slight decrease in median aortic diameter was identified in overall patients: 4.07 cm (interquartile range [IQR], 3.76-4.54 cm) vs 4.06 cm (IQR, 3.74-4.51 cm); P=.04. Further subgroup analysis found that the decrease remained statistically significant in the subgroup of TAV and mild aortic dilation. In addition, no aortic events occurred during long-term follow-up (median, 27 months; IQR, 20-42 months)., Conclusions: TAVI could prevent a further progression of aortic diameter for both BAV or TAV patients by correcting hemodynamic derangements, especially for patients with TAV, mild aortic dilation, and small annulus angles. Aortic events appeared rarely during long-term follow-up after TAVI. However, our results need further confirmation with future investigations in a larger population with longer-term follow-up.
- Published
- 2019
139. Understanding the Interaction Between Transcatheter Aortic Valve Prostheses and Supra-Annular Structures From Post-Implant Stent Geometry.
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Xiong TY, Li YJ, Feng Y, Liao YB, Zhao ZG, Mylotte D, Wei X, Xu YN, Peng Y, Wei JF, Zheng MX, Zhou X, Meng W, Piazza N, and Chen M
- Subjects
- Aged, Aortic Valve diagnostic imaging, Aortic Valve physiopathology, Female, Heart Valve Prosthesis Implantation adverse effects, Hemodynamics, Humans, Male, Multidetector Computed Tomography, Prosthesis Design, Retrospective Studies, Treatment Outcome, Aortic Valve surgery, Heart Valve Prosthesis, Heart Valve Prosthesis Implantation instrumentation, Stents
- Abstract
Objectives: The authors sought to better understand the stent geometry of the Lotus valve after transcatheter aortic valve replacement (TAVR) and its potential implications for valve size selection., Background: The authors hypothesized that the greatest interference between the frame and aortic valvar complex occurs across the aortic valve leaflets., Methods: The authors retrospectively analyzed the multidetector computed tomography (MDCT) scans of 32 consecutive patients undergoing Lotus valve (Boston Scientific, Natick, Massachusetts) implantation. The prosthesis cross section was analyzed at 3-mm increments along its length. The plane where the frame had the smallest area was defined as the waist. The corresponding plane of the waist on pre-procedural MDCT was identified by surrounding structures such as calcium deposits, commissural fusion, and commissural gaps, and was referred to as the supra-annulus. The spline of the supra-annulus was circumscribed with reference to the post-implant stent geometry at the waist., Results: The waist was 5.8 ± 1.7 mm higher than the native annulus on post-procedural MDCT. The waist had a nearly 2-fold larger compression rate than the stent at the native annulus level (36.3 ± 10.4% vs. 18.9 ± 9.6%; p < 0.01), irrespective of valve morphologies. The supra-annulus was 5.9 ± 1.6 mm higher than the annulus on pre-procedural MDCT. Patients had an approximately 17% decrease in area from the annulus to the supra-annulus (18.3 ± 4.4% for bicuspid morphology and 16.0 ± 3.5% for tricuspid morphology)., Conclusions: Major interference between the implanted prosthesis and anatomy occurred at a level above the annulus. The decrease in area from the annulus to supra-annulus may explain the feasibility of implanting a smaller valve than that suggested by traditional annular measurements., (Copyright © 2019. Published by Elsevier Inc.)
- Published
- 2019
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140. Less pronounced reverse left ventricular remodeling in patients with bicuspid aortic stenosis treated with transcatheter aortic valve replacement compared to tricuspid aortic stenosis.
- Author
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Xiong TY, Wang X, Li YJ, Liao YB, Zhao ZG, Wei X, Xu YN, Zheng MX, Zhou X, Peng Y, Wei JF, Feng Y, and Chen M
- Subjects
- Aged, Aortic Valve diagnostic imaging, Aortic Valve physiopathology, Aortic Valve surgery, Aortic Valve Stenosis diagnostic imaging, Aortic Valve Stenosis etiology, Aortic Valve Stenosis physiopathology, Bicuspid Aortic Valve Disease, Echocardiography, Female, Heart Valve Diseases complications, Heart Valve Diseases diagnostic imaging, Heart Valve Diseases physiopathology, Humans, Male, Retrospective Studies, Time Factors, Treatment Outcome, Aortic Valve abnormalities, Aortic Valve Stenosis surgery, Heart Valve Diseases surgery, Transcatheter Aortic Valve Replacement adverse effects, Ventricular Function, Left, Ventricular Remodeling
- Abstract
To compare reverse left ventricular (LV) remodeling after transcatheter aortic valve replacement (TAVR) between patients with bicuspid aortic valve (BAV) and tricuspid aortic valve (TAV). We retrospectively reviewed data of patients with at least two serial echocardiographic follow-ups (1, 3, 6 months and 1 year) post-TAVR. A total of 116 patients were identified. BAV morphology was documented in 67 patients. LV mass index (LVMi) at baseline was not significantly different between the TAV and BAV group (178.0 ± 6.9 vs. 166.3 ± 6.4 g/m
2 , P = 0.14). Reverse LV remodeling was observed in both BAV and TAV patients, but the reduction of LVMi from baseline was significantly more pronounced in TAV patients compared with BAV patients from 6 months post-TAVR (- 56.3 ± 8.1 vs. - 30.0 ± 4.7 g/m2 , P < 0.01 at 6-month follow-up; - 60.6 ± 7.6 vs. - 37.9 ± 6.2 g/m2 , P = 0.02 at 1-year follow-up). EDV value changes during follow-up were similar between patient with TAV and BAV. There were no significant differences in the proportions of patients with more than mild PVL or new permanent pacemaker between TAV and BAV morphology throughout the follow-up. Patients with bicuspid morphology might experience less pronounced reverse LV remodeling post-TAVR than patients with tricuspid morphology.- Published
- 2018
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141. Imaging Evaluation for the Detection of Leaflet Thrombosis After Transcatheter Aortic Valve Replacement.
- Author
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Zhao ZG, Wang MY, and Jilaihawi H
- Subjects
- Graft Occlusion, Vascular diagnostic imaging, Graft Occlusion, Vascular pathology, Humans, Prosthesis Failure, Thrombosis diagnostic imaging, Thrombosis pathology, Time-to-Treatment, Tomography, X-Ray Computed, Aortic Valve, Heart Valve Prosthesis, Postoperative Complications etiology, Thrombosis etiology, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
Subclinical leaflet thrombosis has been increasingly recognized as a common imaging finding after surgical or transcatheter aortic valve replacement (TAVR) in recent studies. This finding has raised concerns over TAVR valve durability and debates on optimal postprocedural antithrombotic regime. Hypoattenuated leaflet thickening (HALT) and the associated reduced leaflet motion (RELM) were noted as computed tomography hallmarks of the phenomenon. The coexistence of HALT and significant RELM has been suggested as a threshold for reporting of subclinical leaflet thrombosis. This methodology may contribute to the standardization of reporting for research collaboration, hence the better understanding and management of this common yet largely unknown phenomenon., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
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142. Gene polymorphisms in dual antiplatelet therapy and the presence of hypo-attenuated leaflet thickening after transcatheter aortic valve replacement.
- Author
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Xiong TY, Liao YB, Feng Y, Zhao MY, Zhao ZG, Li YJ, Liu XJ, and Chen M
- Subjects
- Aged, Aged, 80 and over, Aspirin pharmacology, Aspirin therapeutic use, Clopidogrel, Cytochrome P-450 CYP2C19 genetics, Drug Resistance genetics, Female, Heart Valve Prosthesis adverse effects, Humans, Male, Pilot Projects, Prospective Studies, Ticlopidine analogs & derivatives, Ticlopidine pharmacology, Ticlopidine therapeutic use, Platelet Aggregation Inhibitors therapeutic use, Polymorphism, Single Nucleotide, Transcatheter Aortic Valve Replacement adverse effects
- Abstract
The imaging finding of hypo-attenuated leaflet thickening (HALT) on bioprosthesis after transcatheter aortic valve replacement (TAVR) has been reported. The underlying mechanism is not clear, but leaflet thrombosis is speculated to be the cause. Heterogeneous antiplatelet responses may play a role in the process. This is a prospective, single-center pilot study in patients who received successful TAVR from June 2012 to November 2016. HALT on post-procedural multi-detector computed tomography. We thoroughly genotyped 34 SNPs and 8 SNPs that have been reported for clopidogrel and aspirin resistance. A total of 148 patients were enrolled. There were 15 patients demonstrating signs of HALT. Patients with HALT had a higher rate of atrial fibrillation (AF) pre-TAVR (33.3 vs. 7.5%, P = 0.01). We found that rs4244285 G>A polymorphism of the CYP2C19 gene was associated with the risk of HALT in the overdominant model (OR 4.00 [1.15-13.97], P = 0.02 for GA vs. GG+AA) adjusted by sex and the presence of pre-TAVR AF. Antiplatelet drug resistance is a reasonable possibility involved in HALT. Potential directions were suggested in polymorphisms of the CYP2C19 gene.
- Published
- 2018
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143. Meta-Analysis of the Effectiveness and Safety of Transcatheter Aortic Valve Implantation Without Balloon Predilation.
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Liao YB, Meng Y, Zhao ZG, Zuo ZL, Li YJ, Xiong TY, Cao JY, Xu YN, Feng Y, and Chen M
- Subjects
- Balloon Valvuloplasty, Humans, Prosthesis Design, Treatment Outcome, Aortic Valve surgery, Aortic Valve Stenosis surgery, Heart Valve Prosthesis, Transcatheter Aortic Valve Replacement methods
- Abstract
Evidence regarding the safety and feasibility of transcatheter aortic valve implantation without balloon predilation (BP) is scarce. A literature search of PubMed, EMBASE, CENTRAL, and major conference proceedings was performed from January 2002 to July 2015. There were 18 studies incorporating 2,443 patients included in the present study. No differences were observed in the baseline characteristics between patients without BP (no-BP) and with BP. Compared with BP, no-BP had a shorter procedure time (no-BP vs BP, 124.2 vs 138.8 minutes, p = 0.008), used less-contrast medium (no-BP vs BP, 126.3 vs 156.3 ml, p = 0.0005) and had a higher success rate (odds ratio [OR] 2.24, 95% CI 1.40 to -3.58). In addition, no-BP was associated with lower incidences of permanent pacemaker implantation (OR 0.45, 95% CI 0.3 to 0.67), grade 2 or greater paravalvular leakage (OR 0.55, 95% CI 0.37 to 0.83), and stroke (OR 0.57, 95% CI 0.32 to 1.0). Furthermore, no-BP was associated with a 0.6-fold decreased risk for 30-day all-cause mortality (OR 0.60, 95% CI 0.39 to 0.92). However, the difference in the risk for permanent pacemaker implantation, grade 2, or higher aortic regurgitation, stroke was noted to be significant only in the subgroup of the CoreValve-dominating studies. In conclusion, no-BP before transcatheter aortic valve implantation was not only safe and feasible but was also associated with fewer complications and short-term mortality in selected patients especially using self-expandable valve., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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144. [Analysis of the relationship between hepatitis B virus precore and basal core promoter mutations and acute-on-chronic liver failure].
- Author
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Ma XY, Han T, Pei YZ, Zhao ZG, Gao YT, Li Y, and Jing L
- Subjects
- Adult, Case-Control Studies, DNA, Viral genetics, End Stage Liver Disease, Female, Genetic Variation, Genotype, Hepatitis B Core Antigens genetics, Humans, Male, Middle Aged, Mutation, Promoter Regions, Genetic, Hepatitis B virology, Hepatitis B virus genetics, Hepatitis B, Chronic virology, Liver Failure virology
- Abstract
Objective: To analyze the relationship between hepatitis B virus (HBV) precore (PC) and basal core promoter (BCP) mutations and HBV-related acute-on-chronic liver failure (HB-ACLF)., Methods: Forty-four patients with HB-ACLF and 28 patients with chronic hepatitis B (CHB; used as controls) were enrolled and venous blood samples were collected from all individuals. The PC and BCP gene fragments were amplified by nested PCR. HBV genotype and BCP/PC mutations were determined by direct sequencing and analysis by BioEdit (version 7.0.9.0). Ten of the HB-ACLF patients were selected for follow-up (range: 2-8 weeks), which included once weekly sera collection to determine the relation of mutations and treatment response. Serum levels of HBV DNA were measured by real-time PCR assay, and alanine aminotransferase, total bilirubin, creatinine and albumin were measured by standard biochemical assay and used to determine the MELD score., Results: All 44 HB-ACLF patients were infected with HBV genotype C. In the CHB group, 26 patients were infected with genotype C and two with genotype B. Single mutations (A1762T, G1764A, T1753V, G1896A, and G1899A) and combined mutations (A1762T + G1764A, G1896A + G1899A, T1753V+ A1762T + G1764A, G1896A + G1899A + A1762T + G1764A, and A1762T + G1764A + G1896A) were more frequently detected in HB-ACLF patients than in CHB patients (P less than 0.05). A significantly higher proportion of PC/BCP wild-type sequences was found in patients with CHB than in patients with HB-ACLF (17.9% vs. 2.3%; x² = 5.440, P = 0.020). The proportion of patients carrying both PC and BCP mutations was significantly higher in HB-ACLF patients than in CHB patients (79.6% vs. 39.3%; x² = 12.021, P = 0.001). The proportion of patients carrying only BCP mutation was 42.9% in the CHB group and 20.5% in the HB-ACLF group (x² = 4.157, P = 0.041). No occurrences of only PC mutation were detected in either the CHB or HB-ACLF group. The combined mutations were present in all 10 of the HB-ACLF follow-up patients. Mutations G1899A, T1753V, and A1846T were correlated with disease recovery. Significant decreases in the MELD score were accompanied by decreases in the A1846T mutation., Conclusion: Significantly more HB-ACLF patients carried HBV with mutations in the PC and BCP than CHB patients. Moreover, more HB-ACLF patients carried HBV with PC + BCP combined mutations and PC mutation only. The G1899A, T1753C, and A1846T mutations were associated with HB-ACLF response to treatment and improvement in liver function.
- Published
- 2012
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145. Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure.
- Author
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Han T, Liu Y, Liu H, Zhu ZY, Li Y, Xiao SX, Guo Z, and Zhao ZG
- Subjects
- Adult, Female, Hepatitis B virus pathogenicity, Humans, Liver Failure diagnosis, Male, Middle Aged, Predictive Value of Tests, ROC Curve, Survival Rate, Hepatitis B virus metabolism, Liver Failure blood, Liver Failure virology, Thymosin blood
- Abstract
Aim: To investigate whether serum thymosin beta4 can provide diagnostic or prognostic information in liver failure patients caused by chronic hepatitis B virus (HBV) infection., Methods: Serum thymosin beta4 levels were measured in 30 patients with acute-on-chronic liver failure (ACLF), 31 patients with chronic liver failure (CLF), 30 patients with compensated liver cirrhosis (CR) and 32 patients with chronic hepatitis B and 30 healthy controls. Serum thymosin beta4 levels were measured by enzyme-linked immunosorbent assay and Child-Pugh and model for end-stage liver disease (MELD) scores were calculated for each patient on admission., Results: Compared with healthy controls, serum thymosin beta4 levels in ACLF, CLF, CR and chronic hepatitis B patients were significantly lower, 6.5047 (4.7879-10.5314) microg/mL vs 0.4632 (0.2759-0.8768) microg/mL, 0.6981 (0.5209-1.2008) microg/mL, 1.8053 (0.8110-2.3397) microg/mL, 3.7803 (1.8570-6.4722) microg/mL, respectively (P < 0.001). The levels of thymosin beta4 in liver failure (ACLF or CLF) patients were markedly lower than that in CR (P < 0.001), and a difference was also found between CLF and ACLF patients (P = 0.038). In patients with chronic liver disease, there was a positive relationship between thymosin beta4 levels and albumin, choline esterase, and platelet (P < 0.001), and negative relationship with alanine aminotransferase (P = 0.020), aspartate aminotransferase, total bilirubin, international normalized ratio of prothrombin time, and Child-Pugh and MELD scores (P < 0.001). Of the 61 liver failure patients, the thymosin beta4 levels of non-survivors were significantly lower than that of survivors (P = 0.007). Receiver operating characteristics analysis identified a thymosin beta4 cutoff level of 0.5708 microg/mL for predicting poor prognosis in all liver failure patients. The serial thymosin beta4 values were observed in 13 liver failure inpatients. Lower initial values were observed in the death. While greater improvement in thymosin beta4 value was found in those who recovered from the disease., Conclusion: Serum thymosin beta4 can be used as an important potential predictor for liver failure caused by chronic HBV infection.
- Published
- 2010
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146. Erratum: Poly[[di-μ(3)-nicotinato-μ(3)-oxalato-samarium(III)silver(I)] dihydrate]. Corrigendum.
- Author
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Zhu LC, Zhao ZG, and Yu SJ
- Abstract
The title of the paper by Zhu, Zhao & Yu [Acta Cryst. (2009), E65, m1105] is corrected.[This corrects the article DOI: 10.1107/S1600536809032115.].
- Published
- 2010
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147. 2-Hydr-oxy-1,6,7,8-tetra-meth-oxy-3-methyl-anthraquinone.
- Author
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Zhu LC, Zhao ZG, and Yu SJ
- Abstract
The title compound, C(19)H(18)O(7), also known as chrysoobtusin, was isolated from Cassia tora L. (Leguminosae). The anthraquinone ring system is almost planar, the dihedral angle between the two benzene rings being 4.27 (4)°. The structure is stabilized by intra- and inter-molecular O-H⋯O and C-H⋯O hydrogen bonds, and by weak π-π stacking inter-actions along the b axis, with a centroid-centroid distance between related benzene rings of 3.800 (4) Å.
- Published
- 2008
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148. [Clinical analysis of 39 cases of heterotopic gastric mucosa in the upper esophagus].
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Song ZY, Huang X, Qian KD, Peng JP, Sun AW, Zhang YY, and Zhao ZG
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Choristoma pathology, Esophageal Diseases pathology, Female, Gastroscopy, Humans, Male, Middle Aged, Choristoma diagnosis, Esophageal Diseases diagnosis, Gastric Mucosa
- Abstract
Objective: To determine accurately the incidence of heterotopic gastric mucosa in the upper esophagus (HGMUE) in China, and to study the macroscopic and microscopic aspects of the lesions and to evaluate the clinical importance of HGMUE., Methods: A prospective study was made among a total of 15,228 consecutive patients, 8,573 male and 6,655 female, aged 54 (8-95), undergoing gastroscopy. Disease histories of all patients were carefully inquired, especially those regarding possible complaints including discomfort of throat and swallowing pain and so on. Special care was taken in the upper esophageal sphincter area to make sure whether the area was adequately inspected. Biopsy specimens from aberrant mucosa were obtained and the sections were stained with haematoxylin and eosin, and Giemsa stain for Helicobacter pylori., Results: HGMUE was found in 39 patients (0.26%) with an average age of 50. Five patients with H. pylori infection in heterotopic gastric mucosa also presented the infection in the stomach. The gastric mucosa was gastric body type in 8 patients, transitional type in 11 patients, and antral pattern in 7 patients. Intestinal metaplasia was found in 5 patients, and mild atypical hyperplasia in 2 patients. An impressive finding was coexistent erosive gastritis in 14 patients (35.9%), Barrett's esophagus in one patient (2.6%), peptic ulcer in 8 patients (20.5%), and a patient had the complication of constriction in the upper esophagus., Conclusion: HGMUE is not rare in China. The presence of inlet patches is possibly correlated with specific symptoms. There are some severe complications in HGMUE, especially esophageal constriction. Close surveillance should be taken for rare cases with metaplasia or dysplasia in HGMUE.
- Published
- 2005
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