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To explore the influence of rosa roxburghii tratt preparation on immune function of arseniasis patients caused by burning coal.According to the diagnosis standard for endemic arseniasis(WS/T 211-2001), 62 cases of arseniasis patients who resided in endemic arseniasis area in Guizhou province were selected and divided stratified randomly into two groups: rosa roxburghii tratt juice treatment group and superoxide dismutase(SOD)-enriched rosa roxburghii tratt juice treatment group, with 31 patients in each group.Each patient took 120 ml/d rosa roxburghii tratt preparation or SOD-enriched rosa roxburghii tratt orally for one month. Another 30 healthy residents from a neighbour township 12 km away where arsenic was not prevalent were selected as controls. A 2 ml blood and 50 ml urine samples were collected from individuals and the urine arsenic contents, peripheral blood T-lymphocyte subsets (CD3(+), CD4(+), CD8(+) T cell), serum immunoglobulin (IgG, IgM, IgA) and complement (C3, C4) were detected. The differences between more than two groups on above indicators were compared. The correlations between urinary arsenic and immune parameters were analyzed.Among the rosa roxburghii tratt juice group, SOD-enriched rosa roxburghii tratt juice before intervention group and the control group, the levels of urine arsenic were (76.55 ± 23.02) , (72.60 ± 25.91) and (26.33 ± 11.30) µg/g Cr respectively and IgG were (11.31 ± 1.68), (11.35 ± 1.94) and (9.23 ± 1.75) g/L respectively. The differences were statistically significant(F values were 82.01, 13.82, both P values0.05). After intervention with rosa roxburghii tratt preparation, the levels of urine arsenic were (53.21 ± 16.51) and (51.72 ± 17.70)µg/g Cr, both decreased than before intervention (t values were 5.80 and 3.78, both P values0.05). The levels of CD3(+) were (44.47 ± 7.14)%, (43.44 ± 6.61)% and (70.78 ± 5.26)%, CD4(+) were (29.87 ± 5.67)%, (29.42 ± 5.87)% and (46.08 ± 5.87)%, CD4(+)/CD8(+) were(1.25 ± 0.42), (1.22 ± 0.39) and (1.79 ± 0.26) and C4 were (0.13 ± 0.08), (0.13 ± 0.09) and (0.20 ± 0.11) g/L respectively among the two treatment group before intervention and the control group. The differences were significant (F values were 178.04, 76.71, 23.13 and 5.26, all P values0.05). After intervention, the levels of CD3(+) were (59.73 ± 7.38)% and (66.31 ± 7.57)%, CD4(+) were (34.00 ± 7.97)% and (39.11 ± 5.81)%, CD4(+)/CD8(+) were (1.41 ± 0.37) and(1.58 ± 0.26), all increased than before intervention(t values were 12.47, 25.18, 5.41, 10.47, 3.22 and 5.05, all P values0.05). The levels of urine arsenic and CD3(+), CD4(+), CD4(+)/CD8(+), C4 were inversely correlated correlation, while positive correlation existed between the level of urine arsenic and IgG(r values were -0.68, -0.56, -0.51, -0.43 and 0.36, all P values0.01).The level of urinary arsenic level is closely related to immune function suppression in arseniasis patients caused by burning coal, rosa roxburghii tratt preparation can effectively improve immune function of arseniasis patients.

Self-assembly from the predesigned Cu(II)5 secondary building unit (SBU) in the ternary Cu(II)-triazolate-sulfoisophthalate system generates three interesting magnetic samples: an open pillared-layer framework with nanosized Cu(II)30 metallamacrocycle-based sublayer (1), a (3,6)-connected 2-fold interpenetrating network consisting of alternating Cu(II)5 and Cu(II)1 cores (2), and a (4,8)-connected architecture constructed from centrosymmetric Cu(II)7 clusters and four-branched 5-sulfoisophthalate (sip(3-)) connectors (3). These various structures significantly result from the variable connectivity and the slight expansion of the predetermined conformationally flexible Cu(II)5 SBUs. Furthermore, these intriguing structural motifs in 1-3 essentially induce different magnetic phenomena. A field-dependent metamagnetic transition from antiferromagnetic ordering to weak ferromagnetism is observed in the frustrated Cu(II)30-based sublayer of 1. The paramagnetic Cu(II)1 core in 2 virtually contributes to an S = (1)/2 spin ground state due to the completely compensated magnetic moment in the 1,2,3-triazolate (ta(-))-bridged Cu(II)5 cluster containing ribbon. In contrast, strong antiferromagnetic interactions in the locally centrosymmetric Cu(II)7 cluster lead to an overall S = (1)/2 spin ground state of 3. Thus, the SBU-derived self-assembly strategy provides important hints for polymetallic cluster based high-dimensional magnetic materials, which also brings a new vision for the design and construction of novel functional materials.

Three extended three-dimensional (3D) magnetic metal-organic frameworks (MMOFs), {[Mn3(H2O)2(atz)4Cl2]·2CH3OH}n (1), {[Mn2(H2O)(atz)2(ip)]·C2H5OH}n (2) and {[Mn2(H2O)2(atz)(btc)]·3H2O·0.7CH3OH}n (3) (atz(-) = 5-aminotetrazolate, ip(2-) = isophthalate and btc(3-) = 1,3,5-benzenetricarboxylate), were respectively obtained by varying the coligands with different numbers of functionalities and molecular topology, and structurally and magnetically characterized. Complex 1 exhibits an eight-connected 3(6)·4(18)·5(3)·6 topological network with linear Mn(II)3 subunits periodically linked by ditopic atz(-) connectors. Complex 2 possesses a pillared-layer framework constructed from undulated {Mn2(atz)2} layers and bidirectional ip(2-) spacers. By contrast, 3 consists of bent one-dimensional (1D) {Mn(atz)} ribbons, which are crosslinked through the carboxylate groups of tripodal btc(3-) connectors to generate a 3D architecture. Structural analysis reveals that the interesting motifs of 1-3 and their diverse linkages are significantly dominated by the cooperate coordination of the mixed ligands to the octahedral Mn(II) ion. Magnetically, 1 displays ferrimagnetic behavior resulting from the periodic arrangement of the net moment in the Mn(II)3 subunit, which is scarcely observed in the homometallic azolate systems. Complex 2 features unusual coexistence of spin-canted antiferromagnetic behavior and field-induced spin-flop transition due to the asymmetric magnetic superexchange within the two-dimensional (2D) {Mn2(atz)2} sublayer. By contrast, only antiferromagnetic ordering is observed in the 1D {Mn(atz)} ribbon of 3. These interesting results suggest that the diverse structural motifs by the cooperate coordination of octahedral Mn(II) ion with the N-rich tetrazolyl group can more significantly direct the magnetic behaviors and could be hopefully utilized upon the construction of novel MMOFs.

Two carboxylate-bridged Dy(III) complexes, [Dy(2)(piv)(5)(μ(3)-OH)(H(2)O)](n) (1) and [Dy(2)(piv)(6)(phen)(2)] (2) (pivH = pivalic acid; phen = 1,10-phenanthroline), have been synthesized and structurally characterized. Complex 1 takes a one-dimensional (1D) chain structure based on [Dy(4)(μ(3)-OH)(2)(piv)(8)(H(2)O)(2)](2+) units, while complex 2 is a dinuclear structure bridged by syn,syn-carboxylates. Magnetic investigation indicates weak ferromagnetic interaction between adjacent Dy(III) ions of the Dy(4) unit in 1 and weak intramolecular antiferromagnetic interaction between Dy(III) ions and/or depopulation of the Dy(III) excited-state Stark sublevels in 2. Alternating-current susceptibility measurements revealed frequency- and temperature-dependent out-of-phase signals under a zero direct-current field in 1, with typical slow magnetic relaxation behavior with an anisotropic barrier U ≈ 4.5 K, while 2 exhibits field-induced single-molecule-magnet behavior with ΔE/k(B) = 28.43 K under a 2 kOe external field.

A (3, 4, 14)-connected framework with complicated distorted triangular magnetic lattices, {[Co(7)(H(2)O)(4)(trz)(8)(sip)(2)]·3H(2)O}(n) (trz = 1,2,4-triazolate, sip = 5-sulfoisophthalate), exhibits continuous field-induced metamagnetic transition from an antiferromagnetic ordering to a ferrimagnetic state at 15 kOe, spin competition at 26 kOe and spin reorientation at 50 kOe, respectively.

A magnetic isolated chain-based substituted cobalt-formate framework was obtained with isonicotine as a spacer. In the chain, canted antiferromagnetic interactions exist in between the Co(II) ions, and slow magnetic relaxation is detected at low temperature. For the block effects of the isonicotine ligands, the complex could be considered as a peculiar example of a weak ferromagnetic single-chain-magnet.

Three new paramagnetic ion-directed coordination frameworks, {[Co(4)(H(2)O)(2)(μ(3)-OH)(2)(atz)(2)(nip)(2)]·3H(2)O}(n) (1), {[Mn(4)(H(2)O)(2)(μ(3)-OH)(2)(atz)(2)(nip)(2)]·H(2)O·MeOH}(n) (2) and {[Cu(2)(H(2)O)(μ(3)-OH)(atz)(nip)]·2H(2)O}(n) (3), were, respectively, obtained by solvo-/hydrothermal reactions of 5-amino-1H-tetrazole (Hatz), 5-nitroisophathalic acid (H(2)nip) with an inorganic Co(II), Mn(II) or Cu(II) salt. The former two complexes are two-dimensional (2D) covalent layers built from butterfly-shaped tetranuclear M(4)(μ(3)-OH)(2) clusters and double atz(-) and nip(2-) linkers. Whereas complex 3 is a 3D framework with scarcely observed corner-sharing Cu(3)(μ(3)-OH) Δ-chains extended by nip(2-) linkages, in which the anionic atz(-) ligand acts as a reinforcement to consolidate the Δ-chain. Magnetically, due to the interplay of the anisotropy of spin carrier and magnetic exchange interactions from the adjacent spin carriers, the complexes exhibit spin-canted antiferromagnetism with a Neel temperature lower than 2.0 K for 1 and an antiferromagnetic ordering with a slight field-induced spin-flop transition for 2. In contrast, complex 3 with a local Kagome sublattice displays spin-frustrated antiferromagnetic behavior with magnetic ordering at 16.0 K.

A novel 3D Mn(II) coordination framework with Kagomé sublattice, [Mn(3)(py)(2)(nip)(2)](n) (py(-) = 2-((1H-tetrazol-5-yl)methyl)pyridine and nip(2-) = 5-nitroisophathalate), was in situ solvothermally synthesized and shows the coexistence of spin-canting, spin-frustration as well as field-induced metamagnetic and spin-flop transitions at 2.9 K.

Three novel 3,5-diamino-1,2,4-triazole (Hdatrz)-based Co(II) coordination complexes, [Co(Hdatrz)(0.5)(H(2)O)(2)(btec)(0.5)](n) (1), {[Co(Hdatrz)(Hbtc)]·H(2)O}(n) (2) and [Co(2)(datrz)(2)(nb)(2)](n) (3) (H(4)btec = 1,2,4,5-benzenetetracarboxylic acid, H(3)btc = 1,3,5-benzenetricarboxylic acid and Hnb = 4-nitrobenzoic acid), were synthesized by incorporating different carboxylate-containing co-ligands and then were structurally and magnetically characterized. Complex 1 is a 3D pillared-layer framework with corrugated Co(II)-btec(4-) layers supported by neutral μ(2)-N1, N4-Hdatrz ligands. In contrast, the other two complexes are chiral (4, 4)- and racemic (4, 8(2))-topological layers with asymmetric μ(2)-N1, N4-Hdatrz-bridged helical chains extended by bis-monodentate Hbtc(2-) ligands for 2 and with a μ(3)-N1, N2, N4-datrz((-)) aggregated Shastry-Sutherland magnetic layer for 3. More interestingly, different magnetic phenomena with a field-induced metamagnetic transition from antiferromagnetic ordering to a ferromagnetic state for 1, spin-canted antiferromagnetism with a T(N) lower than 2.0 K for 2, as well as the coexistence of spin frustration and spin-flop transitions for 3 were observed, which, significantly, are governed by the local low-dimensional magnetic motifs mediated by the carboxylate and/or triazolate heterobridges in the anisotropic Co(II)-triazolate system.

Two 3D coordination polymers with the same components but different structures, [Cu(II)(2)Cu(I)(trz)(3)(Hbtc)](n) (1) and [Cu(4)(Htrz)(2)(mu(3)-OH)(2)(btc)(2)](n) (2), were obtained together by a one-pot hydrothermal reaction of Cu(OAc)(2).H(2)O, 1,2,4-triazole (Htrz), and 1,3,5-benzenetricarboxylic acid (H(3)btc). Complex 1 is a mixed-valence Cu(I/II) honeycomb built from wavy Cu(II)-trz-carboxylate layers and Cu(I) nodes with doubly deprotonated Hbtc(2-) ligands covalently filled in the channels. In contrast, 2 is a tetranuclear [Cu(4)(Htrz)(2)(mu(3)-OH)(2)](6+) cluster-based framework extended by a fully deprotonated btc(3-) ligand, displaying a 3,6-connected topological network. More interestingly, spin-canted antiferromagnetism and overall strong antiferromagnetic couplings up to -147.1 cm(-1) are respectively observed for 1 and 2, which are significantly due to the antisymmetric magnetic exchange in the wavy Cu(II)-trz-carboxylate sublayer of 1 and the cooperative 4-fold heterobridges within the tetranuclear cluster of 2.

To improve the quality of processed grass carp (Ctenopharyngodon idellus) products and control the accumulation of hazardous substances therein, minced grass carp slices were salted for 6 h at room temperature and then inoculated with mixed starter cultures of Lactobacillus casei, Streptococcus lactis, Saccharomyces cerevisiae Hansen and Monascus anka and fermented for 12 h at 30 degrees C. The changes in some characteristics and biogenic amine contents of the fermented muscles were investigated.During the 12 h fermentation at 30 degrees C, muscles inoculated with mixed starter cultures showed a rapid decrease in pH from 6.0 to 5.1 and suppression of the growth of enterobacteria and pseudomonads. The fermented muscles exhibited better colour, appearance, flavour and overall acceptability than the control (P0.05). The changes in non-protein nitrogen and free amino acid contents of the fermented muscles and in their sodium dodecyl sulfate polyacrylamide gel electrophoresis profiles indicated that severe hydrolysis of muscle proteins occurred during fermentation. The accumulation of biogenic amines in the muscles was efficiently reduced by fermentation with mixed starter cultures.Fermentation with mixed starter cultures of L. casei, S. lactis, S. cerevisiae Hansen and M. anka significantly improved the characteristics of grass carp muscles and controlled the accumulation of biogenic amines.

The acidic Protease was extracted from the intestine of the grass carp (Ctenopharyngodon idellus) by 0.1 M sodium phosphate buffer, pH 7.0 at 4 degrees C after neat intestine was defatted with acetone, and partially purified by ammonium sulfate precipitation, gel filtration chromatography and ionic exchange chromatography. SDS-PAGE electrophoresis showed that the enzyme was homogeneous with a relative molecular mass of 28,500. Substrate-PAGE at pH7.0 showed that the purified acidic protease has only an active component. Specificity and inhibiting assays showed that it should be a cathepsin D. The optimal pH and optimal temperature of the enzyme were pH2.5 and 37 degrees C, respectively. It retained only 20% of its initial activity after incubating at 50 degrees C for 30 min. The enzyme lost 81% of its activity after incubation with pepstatin A at room temperature, but was not inhibited by soybean trypsin inhibitor or phenylmethylsulfonyl fluoride (PMSF). Its V(max) and K(m) values were determined to be 3.57 mg/mL and 0.75 min(-1), respectively.

To improve the slotted acetabular augmentation to treat acetabular dysplasia.Fifteen pediatric patients with developmental dysplasia of the hip, 3 male and 12 female, aged 8 - 16, with 20 ill acetabuli, underwent improved slotted acetabular augmentation: a piece of cancellous bone was grafted into a groove of the acetabulum, and the volume of acetabulum was enlarged. The effects were evaluated by clinical examination, X-ray examination, Charnley scoring, and Harris scoring.After the operation, the acetabular covering rate became 85%, and the mean acetabular index was decreased from 35 degrees to 25 degrees.Slotted acetabular augmentation is safe, simple, and effective in the treatment of acetabular dysplasia.

Hedgehog (Hh) signaling plays an important role in embryonic development of many tissues, including the gastrointestinal tract. Sonic Hh-and Indian Hh-deficient mice die before or soon after birth, precluding further study of this signaling pathway in the mature intestine. Maternal transfer of inactivating monoclonal antibodies to Hh proteins (anti-Hh moAb) during late stages of embryogenesis or to early postnatal mice produced intestinal villous abnormalities, progressive runting, and severe malabsorption of dietary fat. In the present study, we sought to determine the effect of inhibiting Hh signaling on weight gain and lipid absorption in adult mice. Anti-Hh moAb was administered to adult Balb/c mice fed either a low-fat, nonpurified diet or a high-fat, semipurified diet, and to adult ob/ob mice fed the low-fat, nonpurified diet. Weight gain was significantly inhibited by anti-Hh moAb treatment in Balb/C mice fed the high-fat, but not the low-fat diet and in ob/ob mice. Further analysis of adult Balb/c mice fed the high-fat diet demonstrated that although total lipid absorption was normal, the rate of triglyceride absorption was significantly delayed in mice treated with anti-Hh moAb and they had significantly increased fecal FFA excretion. Hepatic steatosis, found in high-fat fed Balb/c mice treated with the control moAb, was abrogated by anti-Hh moAb administration. These findings point to a potential role for Hh signaling pathways in diet-induced abnormalities of lipid metabolism.

A new family of coordination polymers, {[Co(Hapt)2]·2H2O}n (1, H2apt = 5-(3′-amine-1′H-pyrazol-4′-yl)-1H-tetrazole), {[Zn(Hapt)2]·3H2O}n (2), {[Cd(Hapt)2]·2.5H2O}n (3) and [Cu(Htpa)2]n (4) have been prepared under hydrothermal conditions and characterized by elemental analyses and X-ray structural analyses. The tetrazole ligand adopts two coordination modes generating two kinds of 2D layers. Among them, 1–3 are isomorphous. Furthermore, extended 3D supramolecular architectures are constructed for these complexes via predictable secondary interactions such as O⋯H–C and O⋯H–N hydrogen bonding. Magnetic studies indicate that compound 1 exhibits magnetic ordering below 4.5 K with spin canting. The fluorescence studies show that the emissions of complexes 2–3 are attributed to the ligand π–π* transition.

Using 2,5-dimethyl-1,3,4-thiodiazole (L) as ligand, a series of Ag(I), Cu(II) and Ni(II) complexes, namely, [Ag4(μ2-L)6(H2O)2](ClO4)4·2H2O (1), [Ag4(μ2-L)4(μ2-CF3CO2)2(μ3-CF3CO2)2] (2), [Ag2(μ2-L)3(CH3CN)2](AsF6)2 (3), [Ag2(μ2-L)2(μ2-NO3)2]n (4), [Cu(L)2(μ2-NO3)2] (5), [Cu(μ2-L)(μ1,1-N3)3(μ2-CH3COO)]n (6) and [Ni9(μ2-L)6(L)3(μ6-CO3)2(DMF)3(H2O)6(μ3-OH)6]2[Ni9(μ2-L)6(μ6-CO3)2(H2O)12(μ3-OH)6](ClO4)24·9H2O (7) were isolated and their crystal structures determined via single-crystal X-ray diffraction. In 1, six L ligands bridge four neighboring Ag(I) centers forming a tetranuclear cation Ag4 cluster. While in 2, μ3-CF3CO2− anions bridge two pairs of di-nuclear silver(I) clusters forming another type of tetranuclear neutral Ag4 cluster. 3 is a dinuclear Ag(I) complex and 4 is a one-dimensional (1D) chain constructed via dinuclear Ag(I) sub-units, in which μ2-NO3− groups bridge neighboring di-nuclear Ag(I) clusters into a 1D polymeric chain. When Cu(NO3)2 was employed in the reaction system instead of silver(I) salts, a mono-nuclear Cu(II) complex 5 was obtained. When Cu(Ac)2 and NaN3 were further introduced in to the reaction system of 5 instead of Cu(NO3)2, a 1D copper(II) chain 6 constructed with dinuclear copper(II) units was isolated, in which three different types of bridging (μ1,1-azido, acetate and L ligands) can be simultaneously observed. It is interesting that when self-assembly of Ni(ClO4)2·6H2O, L, Na2CO3, and NaN3 in the molar ratio of 4 : 2 : 1 : 8 in CH3OH/DMF/H2O produced well-shaped green crystals of 7. Structural analysis revealed that 7 contains two types of Ni9 clusters with an overall Pc1 non-central symmetry. To our knowledge, 7 represents a unique example of M9L6 and M9L9 cages. The result also reveals that it can be expected that using L ligands as precursors has great potential for constructing these functional materials with intriguing structural motifs such as polynuclear metal clusters. Electrospray ionization mass spectrometry measurements studies for 1–4 demonstrate that in a DMSO solution, complex 1 can still retain the form of a tetranuclear silver(I) cluster. In the solid state, complexes 1–4 exhibit strong fluorescent emission bands, which may be assigned to ligand-to-metal charge transfer. The luminescent properties of these complexes in a DMSO solution varied from blue light to green light at ambient temperature.

A [Co(6)(μ(3)-OH)(4)(datrz)(2)](6+) ribbon-based blue framework with a metamagnetic transition from an antiferromagnetic ordering to a weak spontaneous magnetization state, {[Co(3)(CH(3)OH)(μ(3)-OH)(2)(datrz)(sip)]·2.25H(2)O}(n) (1, Hdatrz = 3,5-diamino-1,2,4-triazole, sip(3-) = 3,5-dicarboxybenzenesulfonate), was solvothermally synthesized. 1 exhibits a reversible single-crystal-to-single-crystal transformation by solvent exchange to generate a pink antiferromagnetic ordering coordination layer with a similar [Co(6)(μ(3)-OH)(4)(datrz)(2)](6+) ribbon to 1, {[Co(3)(H(2)O)(3)(μ(3)-OH)(2)(datrz)(sip)]·2.125H(2)O}(n) (2). Such concomitant solvatochromic and solvatomagnetic effects are scarcely observed and are significantly due to the coexistence of differently distorted metal coordination spheres and the cleavage/generation of the weak coordination bond.

Two new 3-amino-1,2,4-triazole (amtrz)-based 3D MOFs, [Cu4(amtrz)2(μ3-OH)2(btc)2]n (1), and [Cu5(amtrz)2(H2O)2(μ3-OH)2(btec)2]n (2) (btc3− = 1,3,5-benzenetricarboxylate and btec4− = 1,2,4,5-benzenetetracarboxylate), were hydrothermally synthesized and structurally and magnetically characterized. Each cationic [Cu4(amtrz)2(μ3-OH)2]6+ cluster in 1 is periodically extended into an infinite 3,6-connected rtl-type topological network via six btc3− ligands. In contrast, analogous CuII4 clusters to 1 and square-planar CuII1 cores in 2 are alternately interlinked through btec4− linkers to generate a 3D (44·62)2(46·64)4(48·66·8)3 framework, which is a scarcely observed higher-dimensional coordination polymer with a CuII4 + CuII1 motif. More interestingly, both the coordination polymers display strong antiferromagnetic couplings up to −154.6 cm−1 due to the favorable multiple heterobridges in the analogous CuII4 component.

A novel 3D framework with vertex- and edge-sharing Δ-ribbons extended by ip(2-) connectors, {[Co(7)(H(2)O)(2)(μ(3)-OH)(4)(atz)(2)(ip)(4)]·5H(2)O}(n) (atz(-) = 5-amino-tetrazolate and ip(2-) = isophthalate), exhibits a two-step field-induced metamagnetic transition from an antiferromagnetic ordering to a weak spontaneous magnetization state by spin-competition at 2.0 KOe, followed by a spin-flop transition at 22.5 KOe.

Four ligand-deprotonation induced coordination polymers, {[Cu4(atr)4(H2O)2(btec)2]·2.5H2O}n (1), {[Cu3(atr)4(H2O)2(μ3-OH)(Hbtec)]·2ClO4·2H2O}n (2), [Cu(atr)2(H2O)(H2btec)]n (3), and [Cu(atr)2(H2O)2(H2btec)]n (4) (atr = 4-amino-1,2,4-triazole and H4btec = 1,2,4,5-benzenetetracarboxylic acid), were obtained by delicate tuning of the pH value of the reactant mixture. All compounds have been structurally and magnetically characterized. The competitive bridging roles of the two different ligands as well as the degree of deprotonation of the aromatic tetracarboxylic ligand resulted in the formation of four different networks: a coplanar CuII4 cluster-based 3D framework for 1, triangular CuII3-core-derived 2D layers for 2, and H2btec2−-bridged 1D zig-zag or linear chains for 3 and 4, respectively. Magnetic measurements reveal antiferromagnetic couplings with variable strength ranging from −188.9 to −0.712 cm−1 within the isolated CuII4, CuII3, and H2btec2−-bridged CuII nodes in 1–4. These couplings are essentially determined by the spatial orientation and coordination characteristics of the homo- and heterobridges between the adjacent spin carriers.

The first hypoxanthine (hypH)-assisted 3D Cu(II)-tetracarboxylate framework, {[Cu(2)(hypH)(0.5)(H(2)O)(0.5)(btec)]·1.5H(2)O}(n) (btec = 1,2,4,5-benzenetetracarboxylate), was synthesized and exhibits long-range ferromagnetic ordering below 4.5 K, which opens a new window for the applications of nucleobase-based MOFs as magnetic materials.

By reaction of a zinc salt, 1,3,5-benzenetricarboxylic acid (H3btc) and 1,2,4-triazole (Htrz) under hydrothermal conditions, three mixed ligands protonation-dominated crystals, showing a 3-D microporous framework for 1, a 3-D pillared-layer structure for 2, and a 1-D chain motif for 3, have been stepwise isolated by crystallization of the reaction mixture and evaporation of the filtrates.