929 results on '"Zhu, Chen"'
Search Results
102. Comparison of Laparoendoscopic Single-Site and Laparoscopic Radical Cystectomy for Male Patients with Bladder Cancer: Perioperative and Oncologic Outcomes.
- Author
-
Zhu, Chen, Zuo, Wenren, Yuan, Lin, Su, Jian, Zhang, Yang, Wei, Yunfei, Shen, Luming, Deng, Zhonglei, Tang, Jingyuan, Wang, Ninghong, Su, Yun, and Zhu, Qingyi
- Subjects
- *
ILEAL conduit surgery , *URINARY diversion , *BLOOD loss estimation , *BLADDER cancer , *LAPAROSCOPIC surgery , *CYSTECTOMY , *CANCER patients , *SURVIVAL , *RESEARCH , *RESEARCH methodology , *SURGICAL complications , *RETROSPECTIVE studies , *EVALUATION research , *TREATMENT effectiveness , *COMPARATIVE studies , *LAPAROSCOPY , *MENTAL health surveys , *LONGITUDINAL method ,BLADDER tumors - Abstract
Objective: To compare the surgical and early oncological outcomes in patients with bladder cancer who had laparoendoscopic single-site radical cystectomy (RC) or laparoscopic RC. Materials and Methods: From July 2012 to May 2019, 28 consecutive men suffering from bladder cancer underwent laparoendoscopic single-site RC or laparoscopic RC with extracorporeally ileal conduit diversion. Data regarding the patient characteristics, surgical outcomes, and short-term oncological outcomes were analyzed retrospectively. Results: Compared with laparoscopic RC, laparoendoscopic single-site RC was associated with less postoperative pain (mean, 4.67 versus 6.08 scores; P = .004), and shorter convalescence (time to ambulation, mean, 1.13 days versus 2.15 days; P = .000; hospital stay after surgery, mean, 13 days versus 19 days; P = .001). In addition, differences in patient characteristics, mean total operation time, and mean estimated blood loss were not statistically significant between laparoendoscopic single-site RC and laparoscopic RC groups. There was no difference in the early or late complication rate between the two groups as well. It is also revealed that there was no significant difference in the overall survival rate at 24 months between laparoendoscopic single-site RC and laparoscopic RC groups. Conclusions: Based on our initial experience with laparoendoscopic single-site RC, it is a safe procedure with acceptable complications and oncological outcomes. Notably, laparoendoscopic single-site RC is associated with less postoperative pain and rapider convalescence compared with the historical series of laparoscopic RC. However, further comparative studies with longer follow-up period are warranted to validate this procedure. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
103. Theoretical insight into the hydrogenolysis mechanism of lignin dimer compounds based on experiments.
- Author
-
Zhu, Chen, Cao, Jing-Pei, Feng, Xiao-Bo, Zhao, Xiao-Yan, Yang, Zhen, Li, Jun, Zhao, Ming, Zhao, Yun-Peng, and Bai, Hong-Cun
- Subjects
- *
LIGNIN structure , *LIGNINS , *PHENYL ethers , *IONIZATION energy , *ACTIVATION energy , *BIOMASS chemicals , *BENZYL ethers - Abstract
Deep insight of reaction mechanism in lignin model compounds is helpful to achieve the directed depolymerization of lignin or biomass to chemicals or fuels. In this study, the density functional theory (DFT) calculation was employed to investigate the cleavage mechanism of the C –O bonds in lignin dimers. Additionally, the intrinsic chemical reactivity of molecular in term of the Fukui function was applied to predict the most probable sites which react with hydrogen free radicals (H·). It was found that the O atoms in lignin dimers are the most reaction site involving H· because of the large f (0). By this method, the most rational path from a series of reaction paths was screen out. Apart from the Fukui function, the average local ionization energy (ALIE) was analyzed to prove the reliability of Fukui function. The kinetic analysis of the reaction path was performed to further understand the impact of temperature on the reaction rate constant (KTST). It is observed that benzyl phenyl ether (BPE) with higher KTST could be easily cleaved because of the relatively low energy barrier. Image 1 • The reaction paths of lignin dimers hydrogenolysis was simulated by DFT. • The Fukui function and average local ionization energy of molecule were calculated. • The reaction sites with H· radicals was predicted based on f (0) and ALIE. • The kinetic studies of lignin dimers hydrogenolysis were explored. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
104. Nonlinear Increase of Vegetation Carbon Storage in Aging Forests and Its Implications for Earth System Models.
- Author
-
Zhu, Chen and Xia, Jianyang
- Subjects
- *
CARBON sequestration in forests , *FOREST measurement , *AGE groups , *PLANT growth - Abstract
Vegetation carbon stock (Cveg) in global forests, which is important for C cycle‐climate feedbacks, commonly increases with forest age. Due to the allometric growth of plants, the nonlinear increase in Cveg with woody fraction (fw) is expected across space. However, it remains unclear whether such a nonlinear relationship between Cveg and fw can be constrained by observations and further used to benchmark Earth system models (ESMs). Here, based on the in situ measurements at 1,145 forest sites, we found that the nonlinear relationship between Cveg and fw followed an exponential equation (i.e., Cveg=bea·fw). Then, we showed that such an exponential dependence of Cveg on fw also exists in ESMs of CMIP5 and CMIP6 (all P < 0.01), even though age‐dependent processes have not been incorporated in most models. However, the exponential Cveg‐fw relationship varied greatly among the models, and the coefficient b was systematically lower in the ESMs (0.08 ± 0.11; mean ± SD) than the observations (0.28). Based on a compiled forest age data set, we further found that the observed nonlinear increase of Cveg with forest age across the Northern Hemisphere (>30°N) was not captured by ESMs. These findings reveal a high disagreement on the spatially nonlinear relationship between vegetation carbon stock and woody fraction in current ESMs. The exponential relationship based on observations provides one useful benchmark for ESMs when they implement the age‐dependent processes in the future. Plain Language Summary: Forest age plays an important role in vegetation carbon stock (Cveg) predictions. This study detects a nonlinear increase of Cveg with woody fraction (fw) in aging forests across 1,145 in situ observations. The nonlinear Cveg‐fw relationship was then used to benchmark the age impacts on Cveg predictions in Earth system models (ESMs). Combined with a global forest age data set, we show that current ESMs divergently represent the relationship between Cveg and forest age. Our study suggests that the Cveg‐fw relationship could be one useful benchmark for evaluating ESMs. Key Points: Observations constrain an exponential relationship in Cveg and fwThe exponential relationship in Cveg and fw could be one useful benchmark for ESMsESMs show divergent relationships between Cveg and forest age [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
105. Evaluation and diagnosis of obstacles to land-based ecological security in resource-based cities: A case study of Xingtai city.
- Author
-
Zhu, Chen, Li, Yuping, Zhang, Luxuan, and Wang, Yanchao
- Subjects
- *
ENVIRONMENTAL security , *ECOLOGICAL assessment , *ANALYTIC hierarchy process , *LAND management , *LAND use , *POLLUTION - Abstract
To provide a theoretical basis for sustainable land resource utilization and a reference for areas with similar natural conditions, an evaluation index for land-based ecological security was constructed based on the Driving force-Pressure-State-Impact-Response (DPSIR) model and the improved analytic hierarchy process (IAHP) and entropy methods, and the land-based ecological security status of Xingtai city from 2006 to 2017 was evaluated. Then, the obstacles to land-based ecological security were diagnosed. The results show that the values of the comprehensive evaluation index of land-based ecological security were 0.28–0.66 in the period from 2006 to 2017. The value of the index of land-based ecological security was low in the first seven years and gradually improved in the last five years of the study period. However, the overall situation was grave, and the ecological security conditions were poor. The main obstacles to land-based ecological security were the usage of pesticides, investment in environmental pollution treatments, the degree of machine cultivation, the rate of cultivation and the usage of fertilizer in Xingtai city. Based on the results of the land-based ecological security evaluation and the main obstacles identified in Xingtai city, this paper proposes management strategies and suggestions for improving land-based ecological security in Xingtai city. The specific proposals are as follows: vigorously develop green agriculture, increase investment in environmental pollution control, increase input in science and technology, and strengthen supervision and management of land use. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
106. Association of abnormal placental perfusion with the risk of male hypospadias: a hospital-based retrospective cohort study.
- Author
-
Zhu, Chen, Zhang, Bin, Peng, Ting, Li, Ming-Qing, Ren, Yun-Yun, and Wu, Jiang-Nan
- Subjects
- *
HYPOSPADIAS , *PLACENTA , *INFANTS , *MULTIVARIATE analysis , *SECOND trimester of pregnancy - Abstract
Background: The effect and extent of abnormal placental perfusion (APP) on the risk of male hypospadias are poorly understood. We compared the prevalence of male hypospadias in the offspring of women with APP and quantify the extent of the APP effect on the anomaly.Methods: A hospital-based retrospective analysis of births from 2012 to 2016 was conducted in 2018. Women of singleton pregnancy and male infants born to them were included (N = 21,447). A multivariate analysis was performed to compare the prevalence of male hypospadias in infants exposed to APP with those that were not exposed to APP.Results: Compared with the infants of women without APP, infants of women with APP showed an increased risk of male hypospadias (odds ratio, 2.40; 95% confidence interval, 1.09-5.29). The male hypospadias cumulative risk increased with the severity of APP. Infants exposed to severe APP had a significantly higher risk of male hypospadias than those without APP exposure (9.2 versus 1.7 per 1000 infants, P < 0.001). A path analysis indicated that 28.18-46.61% of the risk of hypospadias may be attributed to the effect of APP.Conclusions: Male hypospadias risk was associated with APP and increased with APP severity, as measured in the second trimester. APP had an important role in the development of the anomaly. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
107. Progress Toward Sapphire Optical Fiber Sensors for High-Temperature Applications.
- Author
-
Zhu, Chen, Gerald, Rex E., and Huang, Jie
- Subjects
- *
OPTICAL fiber detectors , *SAPPHIRES , *HIGH temperatures , *SILICA fibers , *FUSED silica , *REMOTE sensing - Abstract
High-temperature measurements are of significant importance in various harsh-environment engineering fields, such as fossil fuel production, and the metallurgical and aviation industries. In recent years, there is a steady trend to shift from conventional electronic sensors to optical fiber sensors for high-temperature applications. In particular, optical fiber sensors are small in size, immune to electromagnetic interference, readily applicable for remote sensing, have high elasticity, and incorporate capabilities for multiplexing and distributed sensing. However, commonly used fused silica optical fiber sensors exhibit severe limitations at ultrahigh temperatures due to significantly degraded optical and mechanical properties at temperatures >1000 °C. The excellent optical transparency, thermal and chemical stability, mechanical robustness, and high melting temperature (~2040 °C) of single-crystal sapphire fibers (SFs) make them a strong candidate for sensing applications in high-temperature environments. Translation of the sensing schemes from mature silica fiber sensors to SF sensors has undergone tremendous growth and advancements in the past two decades. However, hurdles to the development of a near-term deployable SF sensing system have proven persistent due to the highly multimodal nature of SFs. This article reviews sensing techniques that have been implemented with SFs recently. The aim is to provide a comprehensive summary of past research on SF sensing systems. Perspectives on further research into the challenging yet promising arena are also discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
108. Combined transcriptome sequencing and prokaryotic expression to investigate the key enzyme in the 2-C-methylerythritol-4- phosphate pathway of Osmanthus fragrans.
- Author
-
Rui Xiong, Zhu Chen, Weiyu Wang, Li Jiang, Yan Xiang, and Jun Fan
- Subjects
- *
PYROPHOSPHATES , *ENZYMES , *AROMATIC plants , *SYNTHASES , *FOOD aroma , *TERPENES , *CATALYTIC activity , *ESSENTIAL oils - Abstract
Terpenoids are one of the main components of plant aromas. In the present study we investigated these compounds in Osmanthus fragrans Lour., which is a fragrant plant widely used for the production of essential oils. Quantitative real-time PCR (qRT-PCR) results of enzymes associated with the 2-C-methylerythritol-4-phosphate pathway confirmed that the TPS is a key enzyme for terpenoid synthesis in O. fragrans. In a series of experiments, we identified the TPS candidate genes in O. fragrans and revealed the underlying catalytic activity and subcellular localisation of the encoded proteins. Because there is no available O. fragrans reference genome, we sequenced and analysed its transcriptome and identified two putative TPS genes, OfTPS1 and OfTPS2. According to qRT-PCR analysis, both genes were most highly expressed at the full-bloom stage, suggesting that OfTPS1 and OfTPS2 contribute to O. fragrans terpenoid synthesis. To verify this hypothesis, we constructed prokaryotic expression vectors to obtain protein. In order to study the function of OfTPS1 and OfTPS2 in the synthesis of monoterpenes, the obtained proteins were reacted with geranyl pyrophosphate. As a result, two kinds of monoterpenes, (E)-β-ocimene and linalool, were detected from reaction products, respectively. In conclusion, OfTPS1 and OfTPS2 are both monoterpene synthases. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
109. Probing Changes in Pressure With Subpascal Resolution Using an Optical Fiber Fabry–Perot Interferometer.
- Author
-
Zhu, Chen, Chen, Yizheng, Gerald, Rex E., and Huang, Jie
- Subjects
- *
OPTICAL fibers , *FABRY-Perot interferometers , *INTERFEROMETERS , *OPTICAL fiber detectors , *OPTICAL resolution , *PRESSURE sensors - Abstract
This article reports a novel optical fiber extrinsic Fabry–Perot interferometer (EFPI) for probing pressure changes with subpascal (~0.1 Pa, ~ 1.45 × 10−5 psi) resolution. The principal idea of the sensor is to employ a traditional C-shaped Bourdon tube as a mechanical transducer that is coupled to a highly sensitive EFPI device. The cavity of the EFPI device is formed between a gold-coated mirror, mounted to a concave section of the Bourdon tube, and the endface of an optical fiber mounted at the base section of the Bourdon tube. Based on this design, the pressure-induced deflections of the Bourdon tube are directly correlated with the changes in cavity length of the EFPI, which can be determined by analyzing the interference signals. An experiment based on probing hydrostatic pressure changes induced by the addition of single water droplets to a test chamber was performed to quantify the measurement resolution of the proposed sensor because an apparatus for producing exceedingly small, stable, and reproducible pressure changes does not exist. Compared with conventional optical fiber pressure sensors, the proposed pressure sensor requires a simple fabrication process and can be used to measure pressure changes with high sensitivity (~ 23.5 μm/kPa, cavity length change/pressure change). Moreover, the sensitivity and resolution of the pressure sensor can be flexibly adjusted using Bourdon tubes designed for different dynamic ranges (e.g., 0–70 MPa, 0–10152 psi). It is believed that the proposed novel pressure sensor has the potential to find a wide range of applications that require precise instrumentation. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
110. Enhanced thermoelectric performance of PbTe based materials by Bi doping and introducing MgO nanoparticles.
- Author
-
Zhu, Chen, Zhang, Jian, Ming, Hongwei, Lou, Xunuo, Huang, Lulu, Chen, Tao, Zhang, Baoli, Li, Di, Xin, Hongxing, and Qin, Xiaoying
- Subjects
- *
THERMOELECTRIC materials , *NANOPARTICLES , *CARRIER density , *HIGH temperatures , *THERMAL conductivity , *MATERIALS - Abstract
p-type PbTe has long been realized as an excellent thermoelectric (TE) material in the mediate temperature range; however, its counterpart, n-type PbTe, presents poor TE performance. In order to enhance the thermoelectric performance of n-type PbTe, Pb0.995Bi0.005Te-based composites incorporated with MgO nanoparticles have been prepared, and their thermoelectric properties are investigated. The results show that the power factor can be enhanced by incorporation of MgO nanoparticles at high temperature due to the optimized carrier concentration and remarkable energy filtering effects, and the reduced lattice thermal conductivity is obtained owing to interface scattering. Consequently, the sample Pb0.995Bi0.005Te + 0.3 wt. % MgO presents the largest ZT value, reaching 1.4 at 773 K, indicating that incorporation of MgO in Pb0.995Bi0.005Te is an effective approach to improve its thermoelectric performance. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
111. Effects of intraoperative individualized PEEP on postoperative atelectasis in obese patients: study protocol for a prospective randomized controlled trial.
- Author
-
Zhu, Chen, Yao, Jing-Wen, An, Li-Xin, Bai, Ya-Fan, and Li, Wen-Jing
- Subjects
- *
ELECTRICAL impedance tomography , *RANDOMIZED controlled trials , *POSITIVE end-expiratory pressure , *OBESITY , *ATELECTASIS , *OBESITY complications , *GENERAL anesthesia , *INTRAOPERATIVE care , *BLIND experiment , *LONGITUDINAL method - Abstract
Background: Obese patients undergoing general anesthesia and mechanical ventilation during laparoscopic abdominal surgery commonly have a higher incidence of postoperative pulmonary complications (PPCs), due to factors such as decreasing oxygen reserve, declining functional residual capacity, and reducing lung compliance. Pulmonary atelectasis caused by pneumoperitoneum and mechanical ventilation is further aggravated in obese patients. Recent studies demonstrated that individualized positive end-expiratory pressure (iPEEP) was one of effective lung-protective ventilation strategies. However, there is still no exact method to determine the best iPEEP, especially for obese patients. Here, we will use the best static lung compliance (Cstat) method to determine iPEEP, compared with regular PEEP, by observing the atelectasis area measured by electrical impedance tomography (EIT), and try to prove a better iPEEP setting method for obese patients.Methods: This study is a single-center, two-arm, prospective, randomized control trial. A total number of 80 obese patients with body mass index ≥ 32.5 kg/m2 scheduled for laparoscopic gastric volume reduction and at medium to high risk for PPCs will be enrolled. They will be randomly assigned to control group (PEEP5 group) and iPEEP group. A PEEP of 5 cmH2O will be used in PEEP5 group, whereas an individualized PEEP value determined by a Cstat-directed PEEP titration procedure will be applied in the iPEEP group. Standard lung-protective ventilation methods such as low tidal volumes (7 ml/kg, predicted body weight, PBW), a fraction of inspired oxygen ≥ 0.5, and recruitment maneuvers (RM) will be applied during and after operation in both groups. Primary endpoints will be postoperative atelectasis measured by chest electrical impedance tomography (EIT) and intraoperative oxygen index. Secondary endpoints will be serum IL-6, TNF-α, procalcitonin (PCT) kinetics during and after surgery, incidence of PPCs, organ dysfunction, length of in-hospital stay, and hospital expense.Discussion: Although there are several studies about the effect of iPEEP titration on perioperative PPCs in obese patients recently, the iPEEP setting method they used was complex and was not always feasible in routine clinical practice. This trial will assess a possible simple method to determine individualized optimal PEEP in obese patients and try to demonstrate that individualized PEEP with lung-protective ventilation methods is necessary for obese patients undergoing general surgery. The results of this trial will support anesthesiologist a feasible Cstat-directed PEEP titration method during anesthesia for obese patients in attempt to prevent PPCs.Trial Registration: www.chictr.org.cn ChiCTR1900026466. Registered on 11 October 2019. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
112. Epigenetic regulation in plant abiotic stress responses.
- Author
-
Chang, Ya‐Nan, Zhu, Chen, Jiang, Jing, Zhang, Huiming, Zhu, Jian‐Kang, and Duan, Cheng‐Guo
- Subjects
- *
ABIOTIC stress , *EPIGENETICS , *EUKARYOTIC cells , *EPIGENOMICS , *ABSCISIC acid , *GENE expression - Abstract
In eukaryotic cells, gene expression is greatly influenced by the dynamic chromatin environment. Epigenetic mechanisms, including covalent modifications to DNA and histone tails and the accessibility of chromatin, create various chromatin states for stress‐responsive gene expression that is important for adaptation to harsh environmental conditions. Recent studies have revealed that many epigenetic factors participate in abiotic stress responses, and various chromatin modifications are changed when plants are exposed to stressful environments. In this review, we summarize recent progress on the cross‐talk between abiotic stress response pathways and epigenetic regulatory pathways in plants. Our review focuses on epigenetic regulation of plant responses to extreme temperatures, drought, salinity, the stress hormone abscisic acid, nutrient limitations and ultraviolet stress, and on epigenetic mechanisms of stress memory. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
113. Helicobacter hepaticus infection induces chronic hepatitis and fibrosis in male BALB/c mice via the activation of NF‐κB, Stat3, and MAPK signaling pathways.
- Author
-
Cao, Shuyang, Zhu, Chen, Feng, Jie, Zhu, Liqi, Yin, Jun, Xu, Yongliang, Yang, Haitao, Huang, Yuzheng, and Zhang, Quan
- Subjects
- *
HELICOBACTER diseases , *HEPATIC fibrosis , *HEPATITIS , *ASPARTATE aminotransferase , *ALANINE aminotransferase - Abstract
Background: It has been documented that Helicobacter hepaticus (H hepaticus) infection is linked to chronic hepatitis and liver cancer. However, our understanding of the molecular mechanisms underlying progression of the H hepaticus‐induced hepatic inflammation to cellular hepatocarcinoma is still limited. Materials and methods: In our study, male BALB/c mice were infected by H hepaticus for 8, 12, 16, 20, and 24 weeks. Histopathology, H hepaticus colonization dynamics, select signaling pathways, and expression of key inflammatory cytokines in the liver were examined. Results: We found that H hepaticus was detectible in feces of mice at 7 days postinfection (DPI) by PCR, but it was not detected in the livers by PCR until 8 weeks postinfection (WPI). In addition, abundance of colonic and hepatic H hepaticus was progressively increased over the infection duration. H hepaticus‐induced hepatic inflammation and fibrosis were aggravated over the infection duration, and necrosis or cirrhosis developed in the infected liver at 24 WPI H hepaticus infection increased levels of alanine aminotransferase and aspartate aminotransferase. Moreover, mRNA levels of Il‐6 and Tnf‐α were significantly elevated in the livers of H hepaticus‐infected mice compared to uninfected control from 8 WPI to 24 WPI. Furthermore, Stat3, nuclear factor‐κB (p65), and MAPK (Erk1/2 and p38) were activated by H hepaticus infection. Conclusions: These data demonstrated that male BALB/c mice can be used as a new mouse model of H hepaticus‐induced liver diseases and that the H hepaticus‐induced liver injury is triggered by NF‐κB, Jak‐Stat, and MAPK signaling pathways. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
114. Regioselective Hydroalkylation and Arylalkylation of Alkynes by Photoredox/Nickel Dual Catalysis: Application and Mechanism.
- Author
-
Yue, Huifeng, Zhu, Chen, Kancherla, Rajesh, Liu, Fangying, and Rueping, Magnus
- Subjects
- *
ALKYNES , *NICKEL , *DENSITY functional theory , *ARYL bromides , *CATALYSIS , *COUPLING reactions (Chemistry) , *REGIOSELECTIVITY (Chemistry) - Abstract
Alkynes are an important class of organic molecules due to their utility as versatile building blocks in synthesis. Although efforts have been devoted to the difunctionalization of alkynes, general and practical strategies for the direct hydroalkylation and alkylarylation of terminal alkynes under mild reaction conditions are less explored. Herein, we report a photoredox/nickel dual‐catalyzed anti‐Markovnikov‐type hydroalkylation of terminal alkynes as well as a one‐pot arylalkylation of alkynes with alkyl carboxylic acids and aryl bromides via a three‐component cross‐coupling. The results indicate that the transformations proceed via a new mechanism involving a single‐electron transfer with subsequent energy‐transfer activation pathways. Moreover, steady‐state and time‐resolved fluorescence‐spectroscopy measurements, density functional theory (DFT) calculations, and wavefunction analysis have been performed to give an insight into the catalytic cycle. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
115. Regioselective Hydroalkylation and Arylalkylation of Alkynes by Photoredox/Nickel Dual Catalysis: Application and Mechanism.
- Author
-
Yue, Huifeng, Zhu, Chen, Kancherla, Rajesh, Liu, Fangying, and Rueping, Magnus
- Subjects
- *
ALKYNES , *NICKEL , *DENSITY functional theory , *ARYL bromides , *CATALYSIS , *COUPLING reactions (Chemistry) , *REGIOSELECTIVITY (Chemistry) - Abstract
Alkynes are an important class of organic molecules due to their utility as versatile building blocks in synthesis. Although efforts have been devoted to the difunctionalization of alkynes, general and practical strategies for the direct hydroalkylation and alkylarylation of terminal alkynes under mild reaction conditions are less explored. Herein, we report a photoredox/nickel dual‐catalyzed anti‐Markovnikov‐type hydroalkylation of terminal alkynes as well as a one‐pot arylalkylation of alkynes with alkyl carboxylic acids and aryl bromides via a three‐component cross‐coupling. The results indicate that the transformations proceed via a new mechanism involving a single‐electron transfer with subsequent energy‐transfer activation pathways. Moreover, steady‐state and time‐resolved fluorescence‐spectroscopy measurements, density functional theory (DFT) calculations, and wavefunction analysis have been performed to give an insight into the catalytic cycle. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
116. Decoupling feldspar dissolution and precipitation rates at near-equilibrium with Si isotope tracers: Implications for modeling silicate weathering.
- Author
-
Zhu, Chen, Donald Rimstidt, J., Zhang, Yilun, Kang, Jinting, Schott, Jacques, and Yuan, Honglin
- Subjects
- *
SILICON isotopes , *MASS spectrometry , *INDUCTIVELY coupled plasma mass spectrometry , *GEOLOGICAL carbon sequestration , *FELDSPAR , *STABLE isotope analysis , *SUPERSATURATED solutions - Abstract
• Novel Si isotope tracer method deconvoluted feldspar dissolution and precipitation. • Feldspar backward reaction is insignificant at low temperatures. • Recommend forward dissolution rates only in low-temperature kinetics models. • This approach for weathering, geological carbon sequestration, and diagenesis. Here we show that the isotope tracer experimental method for kinetic studies, aided by the recent advance and accessibility of multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) analysis for non-traditional stable isotopes, can provide unidirectional dissolution rates at near-equilibrium conditions. For a long time, the only rates available at near-equilibrium were net reaction rates—dissolution rates minus precipitation rates. This is because the conventional experimental method of kinetic studies is based on element concentrations and can only provide net rates. The availability of unidirectional rates allows us to re-examine some fundamental concepts and practices of modeling weathering in geochemistry. In this study, we used the 29Si isotope tracer to conduct albite and K-feldspar dissolution experiments at near-equilibrium conditions in near-neutral pH solutions at 50 °C. Results show that the saturation indices (SI) of solutions approached zero with respect to albite and K-feldspar after ∼240–360 h (h), but 29Si/28Si ratios of the experimental solutions indicated continual dissolution for another 720–1440 h. The rates of total Si precipitation were much smaller than the rates of Si dissolution. The experimental solutions were supersaturated with respect to amorphous Al(OH) 3 , gibbsite, quartz, allophane, imogolite, and kaolinite. The SI of the solutions remained constant with respect to these phases while Al concentrations slightly decreased and Si concentrations slightly increased, indicating the coupled feldspar dissolution and precipitation of secondary phases, such as albite → amorphous Al(OH) 3 + quartz or albite → solution + Al-Si phase(s), instead of significant albite and K-feldspar precipitation (the reverse reaction) at 50 °C. Reaction path modeling of the temporal evolution of Si, Al, Na, and pH revealed that albite dissolution (without significant backward reaction) coupled with the precipitation of a secondary phase with a Si:Al ratio of ∼2:1 can successfully match the experimental data. Given the negligible feldspar precipitation reactions in low-temperature systems (e.g., T < 100 °C), we recommend modeling feldspar weathering using unidirectional forward rates together with secondary phase precipitation rates in near-equilibrium, feldspar-undersaturated systems. This can be accomplished with minor modifications in geochemical modeling software or input files. The coupled feldspar dissolution with secondary phase precipitation arrests the system in a near-equilibrium steady state. Using affinity-based rate equations such the classical linear Transition State Theory rate law or the Burch empirical relation together with far-from-equilibrium rate data will predict significant feldspar precipitation in solutions undersaturated but close to equilibrium with respect to feldspars, which is unlikely at near ambient temperatures. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
117. Using preference leveled evaluation functions to construct fuzzy measures in decision making and evaluation.
- Author
-
Zhu, Chen, Jin, LeSheng, Mesiar, Radko, and Yager, Ronald R.
- Subjects
- *
FUZZY decision making , *FUZZY measure theory , *FUZZY sets , *SPECIAL functions , *AGGREGATION operators - Abstract
This work discusses some new types of bipolar preferences and defines conservativeness of them. Then, the study defines parameterized fuzzy measures and proposes three methods to generate them. Based on given conservativeness preference and some special evaluation functions, we majorly discuss preference leveled evaluation functions method to construct fuzzy measures, allowing the generated fuzzy measures to effectively embody the preferences of decision makers. We also present some related properties such as different types of monotonicities, with three numerical instances showing the applicability of the proposed methods. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
118. Probing the Theoretical Ultimate Limit of Coaxial Cable Sensing: Measuring Nanometer-Scale Displacements.
- Author
-
Zhu, Chen, Gerald, Rex E., Chen, Yizheng, and Huang, Jie
- Subjects
- *
COAXIAL cables , *PLATING , *MICROWAVE spectroscopy , *CHEMICAL detectors , *FABRY-Perot interferometers , *REFLECTANCE , *DISPLACEMENT (Mechanics) - Abstract
Open-ended coaxial probes have been widely explored and commercialized for dielectric spectroscopy at microwave frequencies over the past decades. The working principle of the probes relies on the dependence of the fringing field on the complex permittivity of the material in front of the open end. In this article, inspired by the optical fiber extrinsic Fabry–Perot interferometer, we propose a novel sensing scheme based on an open-ended hollow coaxial cable resonator (OE-HCCR). The resonator is constructed using two reflectors along the coaxial line. The first reflector is a metal post at the RF input end, shorting the inner and outer conductors. The second reflector is the open end, where a metal plate is placed parallel and near the open end. The resonance frequency of the open-ended coaxial resonator depends strongly on the gap distance between the metal plate and the open end of the coaxial cable, due to the modulation of the phase of the reflection coefficient that characterizes the open end. Thus, by correlating the resonance frequency to the gap distance between the metal plate and the open end (or the movement of the metal plate), the OE-HCCR can be used as a displacement sensor device. Importantly, the displacement measurement resolution of the OE-HCCR is three orders of magnitude greater than that of the existing coaxial-cable-based displacement sensors within a certain dynamic range (~0.11 mm), affording a resolution that is comparable to fiber-optic sensors. The mathematical model of the OE-HCCR is discussed in detail, followed by a proof of concept for displacement measurements. The novel OE-HCCR device is suitable for sensing applications in harsh environments and will advance the field of physical/chemical sensing. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
119. IFI30 Is a Novel Immune-Related Target with Predicting Value of Prognosis and Treatment Response in Glioblastoma.
- Author
-
Zhu, Chen, Chen, Xin, Guan, Gefei, Zou, Cunyi, Guo, Qing, Cheng, Peng, Cheng, Wen, and Wu, Anhua
- Subjects
- *
GLIOBLASTOMA multiforme , *GLIOMAS , *OLIGODENDROGLIOMAS , *GENE ontology , *PROGNOSIS , *THERAPEUTICS - Abstract
Purpose: As a crucial part of anti-tumor immunotherapy, interferon-α/β (IFN-α/β) treatment has been broadly applied to clinical trials of glioma. However, less is known about implement of interferon-γ (IFN-γ) in glioma. Further investigating the valuable hub molecular of IFN-γ family might provide us a novel guidance for glioma therapy. Methods: This study carried out an analysis on glioma patients from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) cohorts. The analyses were performed by GraphPad Prism 8 and R language. All the validated experiments were performed three times independently. Results: We identified IFI30 as the most stable independent prognostic gene among 20 classical IFN-γ stimulated genes (ISGs) in glioma patients. Furthermore, we found that IFI30 highly expressed in malignant subtypes of glioma and associated with chemotherapy response. We also found IFI30 could activate IL6-STAT6 signal pathway to decline the glioma cells' chemotherapy sensitivity by performing experiments. Gene ontology (GO) analysis showed IFI30 associated with enhanced leucocyte mediated immune and inflammatory response. Microenvironment analysis referred that high IFI30 expression accompanied with more infiltration of M2 type macrophages. Conclusion: IFI30 is involved in the malignant progression and chemotherapy response of glioblastoma, which can be a potential target for treatment in glioblastoma patients. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
120. Genome-wide identification, molecular evolution, and expression analysis provide new insights into the APETALA2/ethylene responsive factor (AP2/ERF) superfamily in Dimocarpus longan Lour.
- Author
-
Zhang, Shuting, Zhu, Chen, Lyu, Yumeng, Chen, Yan, Zhang, Zihao, Lai, Zhongxiong, and Lin, Yuling
- Subjects
- *
LONGAN , *ABSCISIC acid , *JASMONATE , *MOLECULAR evolution , *SINGLE nucleotide polymorphisms , *TROPICAL fruit , *SOMATIC embryogenesis , *SALICYLIC acid - Abstract
Background: The APETALA2/ethylene responsive factor (AP2/ERF) superfamily members are transcription factors that regulate diverse developmental processes and stress responses in plants. They have been identified in many plants. However, little is known about the AP2/ERF superfamily in longan (Dimocarpus longan Lour.), which is an important tropical/subtropical evergreen fruit tree that produces a variety of bioactive compounds with rich nutritional and medicinal value. We conducted a genome-wide analysis of the AP2/ERF superfamily and its roles in somatic embryogenesis (SE) and developmental processes in longan. Results: A genome-wide survey of the AP2/ERF superfamily was carried out to discover its evolution and function in longan. We identified 125 longan AP2/ERF genes and classified them into the ERF (101 members), AP2 (19 members), RAV (four members) families, and one Soloist. The AP2 and Soloist genes contained one to ten introns, whereas 87 genes in the ERF and RAV families had no introns. Hormone signaling molecules such as methyl jasmonate (MeJA), abscisic acid (ABA), gibberellin, auxin, and salicylic acid (SA), and stress response cis-acting element low-temperature (55) and defense (49) boxes also were identified. We detected diverse single nucleotide polymorphisms (SNPs) between the 'Hong He Zi' (HHZ) and 'SI JI MI' (SJM) cultivars. The number of insertions and deletions (InDels) was far fewer than SNPs. The AP2 family members exhibited more alternative splicing (AS) events in different developmental processes of longan than members of the other families. Expression pattern analysis revealed that some AP2/ERF members regulated early SE and developmental processes in longan seed, root, and flower, and responded to exogenous hormones such as MeJA, SA, and ABA, and 2,4-D, a synthetic auxin. Protein interaction predictions indicated that the Baby Boom (BBM) transcription factor, which was up-regulated at the transcriptional level in early SE, may interact with the LALF/AGL15 network. Conclusions: The comprehensive analysis of molecular evolution and expression patterns suggested that the AP2/ERF superfamily may plays an important role in longan, especially in early SE, and in seed, root, flower, and young fruit. This systematic analysis provides a foundation for further functional characterization of the AP2/ERF superfamily with the aim of longan improvement. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
121. Transurethral-Assisted Transumbilical Laparoendoscopic Single-Site Radical Cystectomy: Initial Short-Term Experience.
- Author
-
Zhu, Chen, Deng, Zhonglei, Yuan, Lin, Su, Jian, Zhang, Yang, Wei, Yunfei, Wang, Ninghong, Lu, Zijie, Su, Yun, and Zhu, Qingyi
- Subjects
- *
SURGICAL complications , *BLOOD loss estimation , *OPERATIVE surgery , *CYSTECTOMY , *TRANSURETHRAL prostatectomy , *BODY mass index , *SURGICAL site - Abstract
Introduction: Laparoendoscopic single-site (LESS) technique is a less invasive approach for radical cystectomy (RC), which is promising in reducing the incisional morbidity and improving the cosmesis of laparoscopic surgery. This study aimed to investigate the clinical and oncological outcomes for patients with malignant urinary bladder tumors that underwent the transurethral-assisted transumbilical LESS-RC. Methods: From December 2014 to June 2017, 47 patients underwent LESS-RC combined with unilateral or bilateral cutaneous ureterostomy were enrolled in this study. The urethra was used as a potential approach without additional incision, which could allow for trocar insertion through natural orifices. Assessments were also conducted on preoperative, perioperative, postoperative, pathologic, and functional outcome data. Results: Mean patient age was 73 years. Mean body mass index was 24.0 kg/m2. Median operating time and estimated blood loss measure 217 min and 178 mL, respectively. Four patients were diagnosed with positive lymph nodes. Two patients had positive surgical margins. No major perioperative complications occurred. Median postoperative follow-up time was 20.1 months. Two patients died due to their progressive disease. Conclusion: LESS can serve as a feasible and effective surgical procedure for RC to treat bladder cancer. With increasing experience and improvements, LESS-RC is promising to be a relatively acceptable alternative for minimally invasive surgery in some specific patients (with generally poor conditions that cannot be tolerated for a long time surgery, short life expectancy, advanced cancer, or associated with intestinal disease). [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
122. Cascade Cross‐Coupling of Dienes: Photoredox and Nickel Dual Catalysis.
- Author
-
Huang, Long, Zhu, Chen, Yi, Liang, Yue, Huifeng, Kancherla, Rajesh, and Rueping, Magnus
- Subjects
- *
DIOLEFINS , *CHEMICAL amplification , *NICKEL , *CATALYSIS - Abstract
Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross‐coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox‐ and nickel‐enabled cascade cross‐coupling process. The cascade reaction furnishes a diverse array of saturated carbo‐ and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
123. Cascade Cross‐Coupling of Dienes: Photoredox and Nickel Dual Catalysis.
- Author
-
Huang, Long, Zhu, Chen, Yi, Liang, Yue, Huifeng, Kancherla, Rajesh, and Rueping, Magnus
- Subjects
- *
DIOLEFINS , *NICKEL , *CHEMICAL amplification , *CATALYSIS - Abstract
Chemical transformations based on cascade reactions have the potential to simplify the preparation of diverse and architecturally complex molecules dramatically. Herein, we disclose an unprecedented and efficient method for the cross‐coupling of radical precursors, dienes, and electrophilic coupling partners via a photoredox‐ and nickel‐enabled cascade cross‐coupling process. The cascade reaction furnishes a diverse array of saturated carbo‐ and heterocyclic scaffolds, thus providing access to a quick gain in C−C bond saturation. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
124. Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study.
- Author
-
Zhu, Chen, Li, Guangzong, Lv, Zhiyu, Li, Jing, Wang, Xiangming, Kang, Jie, and Zhan, Cheng
- Subjects
- *
COGNITION disorders , *LONGITUDINAL method , *LOGISTIC regression analysis , *MINI-Mental State Examination , *GUT microbiome , *STROKE , *TIME , *AMINES , *PSYCHOLOGICAL tests , *CEREBRAL ischemia - Abstract
Background and Aims: Post-stroke cognitive impairment (PSCI) is a clinical condition arising from stroke and causes significant changes to memory, thinking, and behavior. Trimethylamine-N-oxide (TMAO), the metabolite produced by gut microbiota, has mechanistic relevance to atherosclerotic diseases. This study aimed to investigate whether an association existed between elevated plasma TMAO levels and PSCI.Methods: Consecutive patients with acute ischemic stroke were prospectively enrolled during Jan. 2017 to Dec. 2017. TMAO concentration was measured within 24 h after admission. PSCI was assessed using the Mini-Mental State Examination (MMSE) score after 1 year and defined as MMSE score ≤ 26. Binary logistic regression analysis was used to determine the contribution of TMAO level in the prediction of PSCI.Results: Of the 256 patients studied (age, 67.1 ± 11.0 years; male, 54.3%), 86 (33.6%) patients were diagnosed as PSCI. The mean TMAO level was 5.6 ± 2.4 μM, with quartile level as follows: < 3.9 μM (first quartile), 3.9-5.1 μM (second quartile), 5.2-7.4 μM (third quartile), and > 7.4 μM (fourth quartile). After controlling for potential confounders, multivariable logistic analysis showed that higher level of plasma TMAO was an independent predictor for cognitive impairment in post-stroke patients (the quartile 1 was used as reference, the quartile 4 odds ratio, 3.304; 95% confidence intervals, 1.335-8.178; P = 0.010).Conclusions: This study demonstrated that increasing plasma level of TMAO may be associated with PSCI. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
125. Truly Distributed Coaxial Cable Sensing Based on Random Inhomogeneities.
- Author
-
Zhu, Chen, Zhuang, Yiyang, Chen, Yizheng, and Huang, Jie
- Subjects
- *
COAXIAL cables , *STRUCTURAL health monitoring , *ECOLOGICAL disturbances , *OPTICAL fibers , *REFRACTION (Optics) , *CABLE manufacturing - Abstract
Rayleigh backscattering-based distributed fiber optic sensing technology is well known and widely used for large-scale structural health monitoring. Inspired by the Rayleigh backscattering-based sensing methodology on an optical fiber, in this paper, we present a sensing concept based on the random inhomogeneities on a coaxial cable. As an analogy of Rayleigh backscattering along an optical fiber length, “backscattering” also exists from a commercial coaxial cable due to its inherent defects along a cable length which induce a local variation (i.e., impedance mismatch). This is because of the irregular microscopic structures of the inner/outer conductors, and the inhomogeneous density or permittivity of the inner dielectrics after the cables are manufactured. The accumulated backscattered signals along the coaxial cable can be obtained using frequency-domain reflectometry. By analyzing the shift in the local backscattered signal, the local environmental perturbations (e.g., local strain or temperature) can be determined, so that truly distributed sensing capability using a coaxial cable can be achieved. To verify the proposed concept, an intact and commercial coaxial cable was demonstrated for distributed temperature sensing. Compared with the existing coaxial cable-based distributed sensing technologies, the proposed sensing concept does not need extra modifications to the coaxial cable and offers a truly distributed sensing capability. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
126. Achieving high power factor and thermoelectric performance through dual substitution of Zn and Se in tetrahedrites Cu12Sb4S13.
- Author
-
Zhu, Chen, Ming, Hongwei, Huang, Lulu, Zhang, Baoli, Lou, Xunuo, Li, Di, Jabar, Bushra, Xin, Hongxing, Zhang, Jian, and Qin, Xiaoying
- Subjects
- *
THERMOELECTRIC power , *THERMOELECTRIC materials , *PHONON scattering , *ANTIMONY , *CARRIER density , *ELECTRIC conductivity - Abstract
As an environmentally friendly thermoelectric material with its constituents being free of Pb/Te, tetrahedrite Cu12Sb4S13 absorbs much research interest. However, its low thermoelectric performance inhibits its applications. Here, we show that through dual substitution of Se for S and Zn for Cu in the compound, both the electrical conductivity and the thermopower are enhanced, leading to the elevation of the power factor as high as ∼33% (at 723 K). Analyses indicate that the substitution of Se for S gives rise to changes in stoichiometry of Cu12Sb4S13 through precipitation of impurity phase Cu3SbS4, which causes variations of S vacancies and hole concentrations, while Zn2+ substitution for Cu1+ introduces donors, both of which tune and optimize the carrier concentration. Besides, the lattice thermal conductivity of dual substituted samples is reduced by as low as ∼30% (at 723 K) due to intensified phonon scattering of the impurities (Se and Zn). As a result, a large figure of merit ZT = 0.9 (at 723 K) is achieved in Cu12−yZnySb4S12.8Se0.2 samples with y = 0.025 and 0.05, which is ∼41% higher than that of pristine tetrahedrite Cu12Sb4S13, indicating that dual substitution is an effective approach to improving its thermoelectric performance. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
127. Genome-wide investigation of superoxide dismutase (SOD) gene family and their regulatory miRNAs reveal the involvement in abiotic stress and hormone response in tea plant (Camellia sinensis).
- Author
-
Zhou, Chengzhe, Zhu, Chen, Fu, Haifeng, Li, Xiaozhen, Chen, Lan, Lin, Yuling, Lai, Zhongxiong, and Guo, Yuqiong
- Subjects
- *
REGULATOR genes , *GENE families , *ABIOTIC stress , *TEA , *SUPEROXIDE dismutase , *MICRORNA , *PHYSIOLOGICAL effects of cold temperatures , *JASMONATE - Abstract
Superoxide dismutases (SODs), as a family of metalloenzymes related to the removal of reactive oxygen species (ROS), have not previously been investigated at genome-wide level in tea plant. In this study, 10 CsSOD genes were identified in tea plant genome, including 7 Cu/Zn-SODs (CSDs), 2 Fe-SODs (FSDs) and one Mn-SOD (MSD), and phylogenetically classified in three subgroups, respectively. Physico-chemical characteristic, conserved motifs and potential protein interaction analyses about CsSOD proteins were carried out. Exon-intron structures and codon usage bias about CsSOD genes were also examined. Exon-intron structures analysis revealed that different CsSOD genes contained various number of introns. On the basis of the prediction of regulatory miRNAs of CsSODs, a modification 5' RNA ligase-mediated (RLM)-RACE was performed and validated that csn-miR398a-3p-1 directly cleaves CsCSD4. By prediction of cis-acting elements, the expression patterns of 10 CsSOD genes and their regulatory miRNAs were detected under cold, drought, exogenous methyl jasmonate (MeJA) and gibberellin (GA3) treatments. The results showed that most of CsSODs except for CsFSD2 were induced under cold stress and CsCSDs may play primary roles under drought stress; exogenous GA3 and MeJA could also stimulated/inhibited distinct CsSODs at different stages. In addition, we found that csn-miR398a-3p-1 negatively regulated the expression of CsCSD4 may be a crucial regulatory mechanism under cold stress. This study provides a certain basis for the studies about stress resistance in tea plants, even provide insight into comprehending the classification, evolution, diverse functions and influencing factors of expression patterns for CsSOD genes. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
128. Development of q-L-EIV interactive curves for comparison of the environmental performance of composite slabs and RC slabs from the perspective of mechanical features.
- Author
-
Zhu, Chen, Chang, Yuan, Su, Shu, Li, Xiaodong, and Zhang, Zhihui
- Abstract
A building slab, as a main stress component, plays an important structural role. To better understand the environmental performance of various slabs and assist design decision-making considering both environmental protection and structural requirements, this paper evaluated and compared the EIs of two commonly used slabs (RC slabs and composite slabs) with various sectional forms from the perspective of mechanical features. The functional unit was defined as the cross-sectional area of a slab satisfying certain structural span and load requirements. Based on the LCA-based BEPAS model, the EI of slabs were divided into two safeguard areas (resource depletion and ecological damage) and then expressed by the EIV index in units of "yuan" using the willingness to pay (WTP) weighting method. Combining EIV and permitted load-span (q-L) curve, q-L-EIV interactive curves were developed to holistically illustrate the structural and environmental performance of slabs in a single diagram. A series of comparisons were conducted to demonstrate how the developed q-L-EIV interactive curve work to facilitate analysis and selection of slabs. Additionally, sensitivity analyses were performed to evaluate the effects of main parameters (i.e. steel ratio, steel strength, concrete strength and recycling rate) on EIA results of slabs. The research results indicated that there are large differences between the EIs of various slabs, and composite slabs were widely recommended in engineering applications from the view of environmental sustainability. Moreover, the proposed curve can serve as a reference tool of slab design to provide structure-environmental oriented implications in construction industry practice. Unlabelled Image • EIs of CSPSS and RC slabs were compared from perspective of mechanical properties. • The q-L-EIV curves were developed to facilitate the structural design of slabs. • Comparisons from 3 aspects were conducted to elucidate how the curve works. • Sensitivity analyses were performed to identify 5 main factors roles. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
129. Development and validation of an interferon signature predicting prognosis and treatment response for glioblastoma.
- Author
-
Zhu, Chen, Zou, Cunyi, Guan, Gefei, Guo, Qing, Yan, Zihao, Liu, Tianqi, Shen, Shuai, Xu, Xiaoyan, Chen, Chen, Lin, Zhiguo, Cheng, Wen, and Wu, Anhua
- Subjects
- *
THERAPEUTICS , *INTERFERONS , *FUNCTIONAL analysis , *PROGNOSIS , *SURVIVAL analysis (Biometry) - Abstract
Background: Interferon treatment, as an important approach of anti-tumor immunotherapy, has been implemented in multiple clinical trials of glioma. However, only a small number of gliomas benefit from it. Therefore, it is necessary to investigate the clinical role of interferons and to establish robust biomarkers to facilitate its application. Materials and methods: This study reviewed 1,241 glioblastoma (GBM) and 1,068 lower grade glioma (LGG) patients from six glioma cohorts. The transcription matrix and clinical information were analyzed using R software, GraphPad Prism 7 and Medcalc, etc. Immunohistochemical (IHC) staining were performed for validation in protein level. Results: Interferon signaling was significantly enhanced in GBM. An interferon signature was developed based on five interferon genes with prognostic significance, which could reflect various interferon statuses. Survival analysis showed the signature could serve as an unfavorable prognostic factor independently. We also established a nomogram model integrating the risk signature into traditional prognostic factors, which increased the validity of survival prediction. Moreover, high-risk group conferred resistance to chemotherapy and high IFNB1 expression levels. Functional analysis showed that the high-risk group was associated with overloaded immune response. Microenvironment analysis and IHC staining found that high-risk group occupied a disorganized microenvironment which was characterized by an enrichment of M0 macrophages and neutrophils, but less infiltration of activated nature killing (NK) cells and M1 type macrophages. Conclusion: This interferon signature was an independent indicator for unfavorable prognosis and showed great potential for screening out patients who will benefit from chemotherapy and interferon treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
130. Recent advances in alkoxy radical-promoted C–C and C–H bond functionalization starting from free alcohols.
- Author
-
Wu, Xinxin and Zhu, Chen
- Subjects
- *
CHEMICAL bonds , *CARBON-hydrogen bonds , *ABSTRACTION reactions , *SCISSION (Chemistry) , *ALIPHATIC alcohols , *ALCOHOL , *ALCOHOL drinking - Abstract
Direct functionalization of inert C(sp3)–C(sp3) and C(sp3)–H bonds represents one of the most valuable synthetic tactics, yet large obstacles remain in terms of reactivity and selectivity. Alkoxy radicals enable C–C bond scission via β-C elimination and C(sp3)–H bond cleavage through a hydrogen atom transfer (HAT) process, thus providing an efficient method to address these problems. In view of atom- and step-economy, the direct use of abundant alcohols as alkoxy radical precursors in radical transformations is of high synthetic value. This feature article summarizes our recent achievements in (a) C(sp3)–C(sp3) bond cleavage via ring-opening of cycloalkanols and (b) site-specific C(sp3)–H functionalization of unprotected aliphatic alcohols, along with the reconstruction of various new chemical bonds, e.g. C–halogen, C–C, C–N, C–S, and C–Se bonds. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
131. Loneliness and the psychosis continuum: a meta-analysis on positive psychotic experiences and a meta-analysis on negative psychotic experiences.
- Author
-
Chau, Anson K. C., Zhu, Chen, and So, Suzanne Ho-Wai
- Subjects
- *
LONELINESS , *META-analysis , *PARANOIA , *PSYCHOSES , *SYSTEMATIC reviews , *PSYCHOLOGICAL factors - Abstract
There is an increase in interest in the relationships between loneliness and psychosis. The notion of psychosis continuum implies that psychotic experiences extend from clinical populations with psychotic disorders to non-clinical populations. This meta-analytic review aimed to examine the respective associations of loneliness with positive and negative psychotic experiences along the psychosis continuum. A systematic database search was conducted and a total of 30 studies were included in the first meta-analysis and 15 studies were included in the second meta-analysis. There was a medium association between loneliness and positive psychotic experiences (r = 0.302, p < 0.001). In particular, the association between loneliness and paranoia was robust (r = 0.448, p < 0.001). The second meta-analysis revealed a medium association between loneliness and negative psychotic experiences (r = 0.347, p < 0.001). The associations between loneliness and both positive and negative psychotic experiences were found to be smaller among clinical than non-clinical samples. The above findings provided evidence for the associations between loneliness and the two core dimensions of psychotic experiences along the phenomenological continuum. Future research should examine the dynamics of these relationships in both clinical and non-clinical samples, preferably using a single-symptom approach. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
132. Multiple accounting of carbon emission responsibility in the construction sector under different principles: A study from China.
- Author
-
Zhu, Chen, Guo, Guisong, Su, Shu, Hong, Jingke, and Li, Xiaodong
- Subjects
- *
CARBON emissions , *INCENTIVE (Psychology) , *RESPONSIBILITY , *INTERNATIONAL trade , *GREENHOUSE gas mitigation - Abstract
The construction sector is a key actor in fighting climate change. A clear and comprehensive accounting of its carbon emission responsibility is the basis for effective emission mitigation actions. The intersectoral and interregional trade of the construction sector complicates emission responsibility allocation. Neglecting such trade flows or measuring them from a single perspective may cause the sector's emission status to be misinterpreted. Hence, based on the environmentally extended multiregional input-output model, this paper establishes the construction sector's multiprinciple emission responsibility accounting framework and conducts multiple accounting for China's construction sector. The emission distribution and transfer across regions and sectors are systematically revealed, and various accounting principles, regional clusters, and corresponding policy implications are compared and discussed. The results show significant differences in the emission responsibilities of the construction sector under different principles, indicating that the choice of principles will greatly affect the determination of responsibility and corresponding policy priorities, which requires careful consideration. The emission responsibilities in different regions also have notable heterogeneity under each principle and are further clustered into three main emission patterns, suggesting that classified and targeted emission mitigation strategies should be adopted. The emission transfer analysis demonstrates that the construction sector is a typical end-of-chain sector with high emission-pulling effects on upstream industries and tiny emission-pushing effects on downstream industries, resulting in varied incentive impacts under each principle. Overall, this study contributes extensive insights into the emission responsibility of the construction sector, supporting common but differentiated emission reduction targets and policy settings. • A multiprinciple carbon accounting model for the construction sector is developed. • The emission distribution and transfer across regions and sectors are explored. • Accounting principles, emission patterns, and policy implications are compared. • Great disparities under various principles alert multiperspective strategy setting. • Regional heterogeneity in emissions emphasizes differentiated mitigation actions. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
133. Widespread arboreal foraging behavior in ground-dwelling birds and the urgency of life-history studies.
- Author
-
Li, Wande, Zhu, Chen, Grass, Ingo, Han, Peng, Shen, Yao, Ding, Ping, and Si, Xingfeng
- Subjects
- *
FORAGING behavior , *WILDLIFE conservation , *ANIMAL behavior , *FRAGMENTED landscapes , *BIRD behavior , *LIFE history theory - Abstract
Habitat changes can alter animal behaviors, especially of large-bodied animals. Landfowl (Galliformes) are a phylogenetically diverse group of large-bodied ground-dwelling birds that are generally considered reluctant flyers. However, some species of landfowl have also been found to forage in arboreal habitats, which could be particularly advantageous under declining habitat quality. However, the prevalence of arboreal foraging behavior (AFB) and how it relates to habitat changes are still unexplored. Here, we reviewed life-history traits associated with foraging behaviors in 305 species of landfowl worldwide and examined the prevalence of AFB across the global landfowl phylogeny. We also collected data from arboreal camera traps on 22 subtropical reservoir islands and six nearby mainland sites in the Thousand Island Lake region of China to assess AFB of Silver Pheasant (Lophura nycthemera), the largest landfowl in this lake system, with island area and isolation. Globally, at least 84 species of landfowl (28%) showed evidence of AFB, with a strong phylogenetic signal. Camera trapping revealed that Silver Pheasant tended to have AFB on small and isolated islands, as evidenced by the increased arboreal sampling efforts. Our study reveals that landfowl's AFB is much more widespread than previously recognized, and suggests the importance of prioritizing large, connected habitats for the conservation of large-bodied animals like Silver Pheasant in the fragmented landscape. Finally, camera trapping emerges as a promising tool for recording landfowl's life history and uncommon behaviors that can help us understand landfowl's threats and aid conservation programs. • Arboreal foraging behavior is widespread in Galliformes worldwide. • Large and connected habitats should be prioritized for conservation actions. • Camera trapping emerges as a promising tool for understanding landfowl's threats and aiding conservation programs. • Fundamental research on life history are still needed for wildlife conservation. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
134. The landscape of novel strategies for acute myeloid leukemia treatment: Therapeutic trends, challenges, and future directions.
- Author
-
Wu, Ri Han, Zhu, Chen Ying, Yu, Pei Han, Ma, Yafang, Hussain, Liaqat, Naranmandura, Hua, and Wang, Qian Qian
- Subjects
- *
ACUTE myeloid leukemia , *HEMATOLOGIC malignancies , *MOLECULAR spectra , *THERAPEUTICS , *LANDSCAPE changes - Abstract
Acute myeloid leukemia (AML) is a highly heterogeneous subtype of hematological malignancies with a wide spectrum of cytogenetic and molecular abnormalities, which makes it difficult to manage and cure. Along with the deeper understanding of the molecular mechanisms underlying AML pathogenesis, a large cohort of novel targeted therapeutic approaches has emerged, which considerably expands the medical options and changes the therapeutic landscape of AML. Despite that, resistant and refractory cases caused by genomic mutations or bypass signalling activation remain a great challenge. Therefore, discovery of novel treatment targets, optimization of combination strategies, and development of efficient therapeutics are urgently required. This review provides a detailed and comprehensive discussion on the advantages and limitations of targeted therapies as a single agent or in combination with others. Furthermore, the innovative therapeutic approaches including hyperthermia, monoclonal antibody-based therapy, and CAR-T cell therapy are also introduced, which may provide safe and viable options for the treatment of patients with AML. • Acute myeloid leukemia (AML) is highly heterogeneous with a wide spectrum of cytogenetic and molecular abnormalities. • The emergence of targeted therapeutic approaches expands the medical options and changes the therapeutic landscape of AML. • Drug resistance caused by genomic mutations remain a great challenge. • Combination therapies exhibit superior clinical efficacy and better safety profile in AML. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
135. Lithium-ion battery degradation diagnosis and state-of-health estimation with half cell electrode potential.
- Author
-
Zhu, Chen, Sun, Liqing, Chen, Cheng, Tian, Jinpeng, Shen, Weixiang, and Xiong, Rui
- Subjects
- *
OPEN-circuit voltage , *ELECTRODE potential , *LITHIUM-ion batteries , *ELECTRIC vehicles , *DIAGNOSIS - Abstract
• A model for SOH estimation and degradation diagnosis is present. • Proposing a method to select appropriate segments of charging data as model input. • This model development process does not rely on aging data. • The method is validated on real aging data. Lithium-ion batteries (LiBs) have been widely used in electric vehicles and portable electronics. However, the performance and safety of these applications are highly dependent on degradation of LiBs. In this paper, three contributions have been made to achieve reliable degradation diagnosis and State-of-Health (SOH) estimation: (1) Open-circuit voltage is reconstructed to diagnose degradation modes of LiBs by performing scaling and translation transformations on open-circuit potential curves. (2) A degradation diagnosis model is developed to quantify aging characteristics of LiBs. In this model, a segment of charging data is taken to estimate SOH and the degradation modes in a degradation path. (3) An appropriate voltage range of the charging data is selected to improve model estimation accuracy. Experimental results show that the proposed method can achieve reliable degradation diagnosis and accurate SOH estimation with the maximum error of 1.44%. [Display omitted] [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
136. Crystal structure of 3,3′-(1,2-phenylene-bis(methylene))bis(1-vinyl- 1H-imidazol-3-ium) bis(hexafluoro phosphate)(V), C18H20F12N4P2.
- Author
-
Ting, Huang, Jin-Zhu, Chen, Xu-Liang, Nie, Jing, Chen, and Wan-Ming, Xiong
- Subjects
- *
CRYSTAL structure , *PHOSPHATES - Abstract
C18H20F12N4P2, monoclinic, P21/n (no. 14), a = 8.3185(9) Å, b = 21.883(2) Å, c = 13.4345(15) Å, β = 103.4730(10)°, V = 2378.3(5) Å3, Z = 4, Rgt(F) = 0.0470, wRref(F2) = 0.1305, T = 296(2) K. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
137. Flying Blind: Geochemical Modeling and Thermodynamic Data Files.
- Author
-
Zhu, Chen and Nordstrom, D. Kirk
- Subjects
- *
GEOCHEMICAL modeling , *THERMODYNAMICS , *DATA modeling , *EARTH sciences , *ACTIVITY coefficients , *CHEMICAL kinetics - Abstract
Internal consistency implies, at a minimum, that the thermodynamic relationships, reference and standard states, and activity coefficient models are consistently applied to all data within a given TDF. A TDF provides equilibrium constants for reactions involving solids, aqueous species, gases, adsorbed surface species, and ion-exchange species. A TDF may also provide parameters for modeling kinetics of mineral dissolution and precipitation, activity coefficients of aqueous species, and fugacity coefficients of gaseous species. [Extracted from the article]
- Published
- 2022
- Full Text
- View/download PDF
138. Anterior cruciate ligament reconstruction using an anterior cruciate ligament stump.
- Author
-
Tie-Zhu Chen, Yi-Sheng Wang, and Xiao-Sheng Li
- Subjects
- *
ANTERIOR cruciate ligament , *KNEE pain , *PROPRIOCEPTION - Abstract
Introduction: Anterior cruciate ligament (ACL) injury always leads to knee pain and dysfunction for which surgical reconstruction is recommended, with good clinical results, but decreased postoperative proprioception also tends to occur. ACL stump (ACLS)-retaining ACL reconstruction and non-ACLS-retaining ACL reconstruction are the two surgical options. Aim: To investigate the efficacy of retaining the ACLS in allograft reconstruction. Material and methods: Thirty patients were retrospectively assigned to group A, ACLS-retaining ACL reconstruction; and group B, non-ACLS-retaining ACL reconstruction, and their data were analyzed. The knee function (Lysholm score and Tegner motion score) and proprioceptive function of the two groups were assessed and compared by postoperative reconstruction angle. Results: The 30 patients were followed up for a mean 20 months. The mean Lysholm score in group A increased from 55.7 ±11.6 points preoperatively to 95.2 ±5.7 points postoperatively; that in group B increased from 56.7 ±11.3 points preoperatively to 94.6 ±7.2 points postoperatively. The mean Tegner motion score in group A was increased from 2.4 ±0.7 points preoperatively to 6.0 ±0.7 points postoperatively; that in group B increased from 2.73 ±0.96 points preoperatively to 6.24 ±0.48 points postoperatively; the postoperative scores did not differ significantly between the two groups. The proprioception was better in group A than in group B at 3, 6, and 12 months postoperatively (p < 0.05). Conclusions: ACLS-retaining ACL reconstruction has good efficacy and the retained ACLS can benefit postoperative proprioception recovery at an early stage. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
139. A dynamic weighting system considering temporal variations using the DTT approach in LCA of buildings.
- Author
-
Su, Shu, Zhu, Chen, and Li, Xiaodong
- Subjects
- *
DYNAMICAL systems , *DWELLINGS , *ENVIRONMENTAL policy , *MONETIZATION ,ENVIRONMENTAL protection planning - Abstract
Abstract Weighting is an important step that supports comparison and decision-making in the LCA (Life Cycle Assessment) of buildings. However, temporal variations of weighting systems have not been adequately studied. Given the increasing demand of addressing time issues in LCA, this study attempts to develop a dynamic weighting system. Three common weighting approaches—expert panel, monetization, and DTT (distance-to-target)—are compared, and the DTT approach is selected for utilization. Temporal variations of emission targets and resource characteristics are considered in the new weighting system, which includes short-term, medium-term, and long-term weighting factors. The dynamic weighting system makes it possible to quantify environmental impacts with temporal-varying environmental policies and planning, and the assessment results could better guide design improvements with various environmental priorities in different periods considered. A residential building is taken as case to test the operability of the new weighting system. The significant difference between the assessment results weighted by the traditional versus the dynamic weighting systems indicates the necessity of considering temporal variations. Highlights • 3 weighting approaches are compared to determine which is most feasible for the development of a dynamic weighting system. • A dynamic weighting system is developed with calculation formulas and data sources. • Emission indicators from a set of typical years are employed as target levels. • The temporal variances of resource characteristics are considered. • Case study indicates the necessity of considering time variances in weighting system. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
140. Preparation and adsorption properties of 3D graphene synergistic magnetic functional materials.
- Author
-
ZHU Chen, LIU Min, LI Xiaoyan, LIU Li, and WANG Fang
- Abstract
Fe3O4 nanoparticles were synthesized by co-precipitation method. 3D graphene was modified on the surface of Fe3O4 nanoparticles, and then covered with tetraethyl orthosilicate(TEOS) and vinyltrimethoxysilane (VTMO). Finally, the magnetic functional material Fe3O4@3DG@VTMO@MPS was synthesized by the polymerization of functional monomer 3-mercapto-1-propanesulfonate(MPS) on the surface using "thiol-ene" click chemistry. The structure, morphology and thermal stability of the functional materials were characterized by scanning electron microscopy(SEM), energy dispersive spectroscopy (EDS), dynamic light scattering (DLS), Fourier transform infrared spectroscopy(FLlR) and thermogravimetric analysis(TGA), respectively. The adsorption properties of this functional material for Lysozyme were studied by static adsorption experiments. The results show that the magnetic functional materials had nice adsorption capacity (the maximum adsorption capacity was 162.1 mg/g) and fast adsorption kinetics(the adsorption equilibrium could be reached in 150 min). The pseudo-second-order kinetic model was suitable for describing the adsorption kinetics of lysozyme on functional materials, and the adsorption process of functional materials on lysozyme was more in line with Langmuir adsorption model, indicating that adsorption is monolayer adsorption. Fe3O4@3DG@VTMO@MPS as solid phase extraction materials as solid phase extraction materials could be used for separation and enrichment of lysozyme, then combined with high performance liquid chromatography (HPLC) to detect honey in actual samples. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
141. CD48 is a key molecule of immunomodulation affecting prognosis in glioma.
- Author
-
Zou, Cunyi, Zhu, Chen, Guan, Gefei, Guo, Qing, Liu, Tianqi, Shen, Shuai, Yan, Zihao, Xu, Xiaoyan, Lin, Zhiguo, Chen, Ling, Wu, Anhua, and Cheng, Wen
- Subjects
- *
IMMUNOREGULATION , *GLIOMAS , *PROGNOSIS , *RNA sequencing , *IMMUNE response - Abstract
Purpose: Glioma is a refractory disease associated with immune cell infiltration, and the effectiveness of checkpoint blockade remains suboptimal. As an adhesion and costimulatory molecule, CD48 plays a significant role in immunomodulation. As such, studying CD48 may provide additional understanding of the immune and inflammation response of glioma. Methods: Using R language and GraphPad Prism 7, RNA sequencing data of 946 patients from Chinese Glioma Genome Atlas and The Cancer Genome Atlas cohorts were analyzed. Results: CD48 was highly expressed in the malignant progression of glioma. As an independent risk factor, high-CD48 patients were associated with poor prognosis. CD48 influenced glioma purity and the local immune cell subpopulation. CD48 was closely related to immune function in glioma. Patients with an enhanced immune phenotype, high CD48, were associated with immune suppressive molecules and checkpoints. In addition, CD48 correlated with the immune and inflammatory response. A checkpoint risk score including CD48, SLAMF8 and PD-L1 was used to assess the role of checkpoints. Risk score was particularly high in a malignant subtype of glioma and was an independent predictive indicator of unfavorable outcome. Additionally, age, IDH subtype and MGMT promoter status influenced the predictive significance of checkpoint risk score. Conclusion: CD48 exhibits a crucial role in reduced survival and immunomodulation in glioma. In addition, we found that checkpoints play a greater role in patients older than 40 years old with IDH wild-type and MGMT methylated status. These findings suggest that combining CD48 blockade with PD-L1 may be a promising approach to glioma immunotherapy for specific subpopulations of patients. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
142. Recent Advances in Radical‐Mediated C—C Bond Fragmentation of Non‐Strained Molecules.
- Author
-
Wu, Xinxin and Zhu, Chen
- Subjects
- *
CARBON-carbon bonds , *SCISSION (Chemistry) , *ALKANES , *ORGANIC chemistry , *STRAIN theory (Chemistry) - Abstract
The carbon‐carbon (C—C) σ‐bonds construct the fundamental frameworks of organic molecules. The direct functionalization of C—C bonds represents one of the most efficient and step‐economical transformations in synthetic chemistry. The past few decades have witnessed the fast development of transition‐metal mediated C—C bond activation. In contrast, the radical‐promoted C—C bond cleavage has received relatively less attention. As the occurrence of ring strain significantly facilitates the fission of cyclic C—C bonds via radical approaches, the strain relief‐driven C—C bond activation mostly relies on the three‐ and four‐membered rings. The C—C activation of non‐strained molecules such as medium‐ or large‐sized rings and linear alkanes remains challenging. In this review, we will focus on the recent advances in radical‐mediated C—C bond activation of non‐strained molecules. Herein, the alkoxy‐ and iminyl‐radical triggered scission of non‐strained C—C bonds and C—C cleavage via the strategy of remote functional group migration is summarized. The recent advances in radical‐mediated C—C bond activation of non‐strained molecules are summarized in this review. These transformations are mainly accomplished during the past three years, thus representing an emerging topic in organic chemistry. The alkoxy‐ and iminyl‐radical triggered cleavage of non‐strained C—C bonds and the C—C activation via the strategy of remote functional group migration are discussed in details. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
143. Generalised component model for structural steel joints.
- Author
-
Zhu, Chen, Rasmussen, Kim J.R., and Yan, Shen
- Subjects
- *
STRUCTURAL steel , *JOINTS (Engineering) , *DEFORMATIONS (Mechanics) , *MECHANICAL loads , *STRUCTURAL plates - Abstract
Abstract This paper presents a generalised component model for structural steel joints that extends the Component Method to the post-ultimate and post-fracture ranges. In this approach, a tri-linear spring model was developed for each individual component to include their post-ultimate behaviour, and a new concept of the instantaneous centre of rotation was introduced to track the changing load condition of each series of springs in a multi-spring system. The proposed generalised component model can predict the full-range M − θ curves of multi-spring models containing any number of deformable springs, and does not pose numerical difficulties in the post-ultimate range where some springs unload. The method is potentially applicable to all types of steel joints. The paper presents the application of the method to recent experimental tests on bolted moment end plate connections, showing good agreement over the full range of behaviour including fracture. The paper also demonstrates the application of the method to produce the backbone curve for a hysteretic model for the bolted moment end-plate connection. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
144. A model to evaluate the effect of shading objects on the energy yield gain of bifacial modules.
- Author
-
Zhu, Qiangzhong, Zhu, Chen, Liu, Songmin, Shen, Chanjun, Zhao, Wei, Chen, Zhenbo, Chen, Ling, Wang, Jianbo, Wang, Lichun, Zhang, Shengcheng, and Lv, Jun
- Subjects
- *
PHOTOVOLTAIC power systems , *SURFACE charges , *CALORIC expenditure , *ENERGY consumption , *OPTICAL losses - Abstract
Highlights • Developed an optical mode to evaluate the shading effect of the system holders and frames. • A 40 mm square beam could introduce 49% optical loss to the bifacial modules without system design optimizing. • The irradiation loss by frame could be 6–18%, which depends on the frame height. • The shading objects should be smaller and 40 mm far away from the modules to get high energy yield gain of bifacial modules. Abstract Bifacial modules become popular due to the backside yield gain, which can reduce the levelized cost of energy (LCOE) of photovoltaic system dramatically; the technical development of bifacial cell and double glass module technology are also important for the explosion of bifacial market. More and more people are attracted by the energy yield gain of bifacial modules; however, only little studies focus on the effect of backside shading objects on the module and system that would influence the energy yield gain. In this paper, an optic model is developed to evaluate the effect of the shading objects. The energy loss by the shading objects is also estimated by simulation and experiment. The result shows that when the shading objects are 40 mm vertical away from the modules, the shading effect could be greatly reduced. The frame height of bifacial modules should be smaller to reduce the shading effect by frames. It is better to remove the surface C of the frames to optimize the energy yield ability of bifacial modules. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
145. A Comparison of Prediction of Adverse Perinatal Outcomes between Hadlock and INTERGROWTH-21st Standards at the Third Trimester.
- Author
-
Zhu, Chen, Ren, Yun-Yun, Wu, Jiang-Nan, and Zhou, Qiong-Jie
- Subjects
- *
PREGNANCY complications , *BODY weight , *CONFIDENCE intervals , *FETAL growth retardation , *FETAL ultrasonic imaging , *LONGITUDINAL method , *THIRD trimester of pregnancy , *FETAL development , *PROPORTIONAL hazards models , *RECEIVER operating characteristic curves , *ODDS ratio , *DIAGNOSIS - Abstract
Little is known about the clinical value of the Hadlock and INTERGROWTH-21st EFW standards for predicting adverse perinatal outcomes (APOs) in the third trimester. The purpose of this study was to study the association between low estimated fetal weight percentile (EFWc) in the third trimester and the risk of APOs and compare predictions of APOs between Hadlock and INTERGROWTH-21st EFW standards. A prospective cohort of 690 singleton pregnancies with ultrasonography performed in the third trimester between March 2015 and March 2016 in China was conducted. EFW and the corresponding EFWc were measured using the Hadlock and INTERGROWTH-21st standards, respectively. Cox proportional hazard models were used to assess the relationship between low EFWc (i.e., <5 percentile, P5) and the risk of APOs. Compared with fetuses with ≥P5 of the EFWc, fetuses with
- Published
- 2019
- Full Text
- View/download PDF
146. Contactless liquid interface measurement based on a hollow coaxial cable resonator.
- Author
-
Zhu, Chen, Zhuang, Yiyang, Chen, Yizheng, Zhang, Bohong, and Huang, Jie
- Subjects
- *
LIQUID surfaces , *FABRY-Perot resonators , *PERMITTIVITY , *COAXIAL cables , *ELECTROMAGNETIC waves - Abstract
Highlights • A non-contact liquid interface sensor based on a hollow coaxial cable Fabry-Perot resonator is for the first time reported. • The proposed sensor also has the ability for contactless measurement of liquid dielectric constant. • The sensor offers a robust, cost-effective, and real-time configuration for contactless liquid interface detection. Abstract This paper reports a contactless liquid interface sensor based on a microwave Fabry-Perot resonator. A hollow coaxial cable is employed as the sensing platform, in which air serves as the dielectric layer. By shorting the inner and outer conductors of the hollow coaxial cable, two reflectors with high reflectivity (>70%) are created to form a microwave Fabry-Perot resonator. An open groove is engineered on the resonator allowing the electromagnetic wave to interact with the medium outside the cavity. When a container, filled with different layers of liquids, is placed near the groove edge of the sensor, the leaked electromagnetic wave will interact with the liquids inside the container. By correlating the relative permittivity of the liquid mixture to the resonant frequency of the Fabry-Perot resonator, the interface between different liquids can be unambiguously determined. In the demonstration experiment, the water-oil interface and oil-ethanol interface were measured. Meanwhile, the sensor could also be employed to measure the relative permittivity of different liquids in a non-contact fashion. The presented sensor offers a robust, cost-effective, and real-time configuration for contactless liquid interface detection, which has potential applications in the oil and chemical industries. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
147. Association of brain natriuretic peptide gene polymorphisms with chronic obstructive pulmonary disease complicated with pulmonary hypertension and its mechanism.
- Author
-
Guangjun Jin, Zhu Chen, Jiancheng Zhang, Jia Song, Jun Shi, and Bingzhi Zhou
- Abstract
Objective: To examine the association between brain natriuretic peptide (BNP) gene single nucleotide polymorphisms (SNPs) and chronic obstructive pulmonary disease (COPD) and COPD with pulmonary hypertension (PH) and to analyze its mechanism. Methods: The genotypes of BNP at the rs198389, rs6668352, and rs198388 loci in 339 patients with COPD (205 in the COPD/PH− group and 134 in the COPD/PH+ group) and 125 healthy subjects were detected by PCR/Sanger sequencing. The serum levels of BNP, fibrinogen (Fbg), and Apelin were measured in all subjects by ELISA. Results: The BNP rs198389 locus G allele, rs6668352 locus A allele, and 198388 locus T allele were high risk factors for COPD (P<0.001). Logistics regression analysis showed that BNP rs198389 locus G allele, rs6668352 locus A allele, and rs198388 locus T allele were high risk factors for PH in COPD patients (all P<0.001). The levels of the serum BNP and Fbg protein in the control group, COPD/PH− group, and COPD/PH+ group increased successively, and the expression levels of Apelin protein decreased successively (all P<0.001). The BNP and Fbg protein levels in the wild-type, heterozygote, and mutant homozygote in BNP rs198389, rs6668352, and rs198388 loci increased successively, and the serum Apelin protein levels decreased successively (all P<0.001). Conclusion: The polymorphisms of BNP at the rs198389, rs6668352, and rs198388 loci are associated with the occurrence of COPD and COPD with PH, and the occurrence may be related to the abnormal expression level of BNP, Fbg, and Apelin protein in the serum. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
148. A hollow coaxial cable Fabry–Pérot resonator for liquid dielectric constant measurement.
- Author
-
Zhu, Chen, Zhuang, Yiyang, Chen, Yizheng, and Huang, Jie
- Subjects
- *
RESONATORS , *COAXIAL cables , *PERMITTIVITY , *BIOSENSORS , *REFRACTIVE index - Abstract
We report, for the first time, a low-cost and robust homemade hollow coaxial cable Fabry–Pérot resonator (HCC-FPR) for measuring liquid dielectric constant. In the HCC design, the traditional dielectric insulating layer is replaced by air. A metal disk is welded onto the end of the HCC serving as a highly reflective reflector, and an open cavity is engineered on the HCC. After the open cavity is filled with the liquid analyte (e.g., water), the air-liquid interface acts as a highly reflective reflector due to large impedance mismatch. As a result, an HCC-FPR is formed by the two highly reflective reflectors, i.e., the air-liquid interface and the metal disk. We measured the room temperature dielectric constant for ethanol/water mixtures with different concentrations using this homemade HCC-FPR. Monitoring the evaporation of ethanol in ethanol/water mixtures was also conducted to demonstrate the ability of the sensor for continuously monitoring the change in dielectric constant. The results revealed that the HCC-FPR could be a promising evaporation rate detection platform with high performance. Due to its great advantages, such as high robustness, simple configuration, and ease of fabrication, the novel HCC-FPR based liquid dielectric constant sensor is believed to be of high interest in various fields. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
149. Digital glass forming of photonics.
- Author
-
Capps, Nicholas, Zhu, Chen, Goldstein, Jonathan, and Kinzel, Edward
- Subjects
- *
SINGLE-mode optical fibers , *HIGH power lasers , *FUSED silica , *LIGHT transmission , *OPTICAL losses , *LASER deposition , *FIBER lasers , *PHOTONICS - Abstract
We investigate the digital glass forming process for depositing commercial SMF-28 single-mode optical fiber for photonic purposes. The process utilizes a CO2 laser to locally heat the feedstock to fuse it onto a fused quartz substrate. We focus on how altering the deposition parameters, including the laser power, feed rate, and path plan, affects the deposited fiber morphology and how this affects the optical transmission. At high powers, the fiber bonds strongly to the substrate, resulting in significant changes in fiber morphology and core shape. With a gradient transition between the feedstock geometry and the deposition geometry, high optical transmission for straight line depositions can be achieved. Additional work was performed examining the optical losses when the fiber is deposited around a constant radius curve for different fiber morphologies, with higher losses recorded for higher power samples. Comparing the doping profile of these samples indicates that the gradient of Ge decreases at higher laser power, suggesting the losses are caused by diffusion of the fiber core. This work shows that for high input powers, the optical losses around curves are increased, leading to a tradeoff between the bonding strength and optical transmission for these geometries. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
150. Alternative proteins as fish meal substitution in diets for largemouth bass (Micropterus salmoides): a mini review.
- Author
-
Cheng, Yan, Wu, You Jun, Zhu, Chen Bin, Zhou, Xian Ke, Yang, Shun, and Fei, Hui
- Subjects
- *
FISH meal , *LARGEMOUTH bass , *DIETARY proteins , *PROTEINS , *SUSTAINABILITY , *AQUACULTURE industry - Abstract
Summary: Aquaculture has been challenged to explore alternative proteins to develop efficient feed formulations that foster a sustainable future growth. Largemouth bass (LMB) are economically important cultured fish with a high demand for protein. One of the traditional ingredients used to develop protein diets is fish meal (FM). With the aquaculture industry expanding, the FM price climbs with broadening the imbalance between the supply and requirement. Hence, there is a requisite to explore novel alternative proteins sources. In this review, we summarised recent knowledge about the alternative sources of proteins with potential to partially or fully substitute FM in LMB feed and the shortcomings of present alternative proteins. We also highlight the challenges faced for LMB feed in the substitution of FM with alternative proteins, which need more in‐depth investigations in the future. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.