Search

Abstract Background Governments and societies all over the world pay more and more attention to the research and development of smart buildings. There are numerous research projects on smart buildings that have been or being conducted worldwide. Case presentation In this project report, we give an introduction about a newly launched research project sponsored by the Chinese central government. This project aims to combine information technology and control & optimization methodology to address challenging problems in building energy. To study and implement a decentralized control and optimization paradigm in smart buildings is one of the key tasks of this project. Conclusions The combination of informatics and energy is a very important viewpoint to study the management and operation of modern buildings. Research activities in this area shall contribute a lot to the invention and development of new building industrial opportunities.

Resveratrol has been shown to be a therapeutic agent for cardiovascular disorders by maintaining a lower redox level in vivo through its anti-oxidant properties. Resveratrol can prevent cells from p53- and reactive oxygen species-dependent apoptosis induced by interleukin-1b. We identified an inhibitory effect of resveratrol against oxidative stress and apoptosis using the TUNEL assay in NG-Nitro-l-arginine methyl ester-induced preeclampsia in rats. To investigate a possible association between resveratrol and the apoptosis caused by oxidative stress in vitro, assays for superoxide dismutase and malondialdehyde as well as flow cytometric analyses were conducted in HTR-8/SVneo cells after hypoxic treatment with or without resveratrol for 24 h. These data suggest that resveratrol significantly opposes the effects of oxidative stress in vivo and in vitro.

This paper presents a novel control system for chiller plants that is decentralized and flat-structured. Each device in chiller plant system is fitted with a smart node. It is a smart agent, which collects, handles and sends out information to its neighbours. All the smart nodes form a network that can realize self-organization and self-recognition. Different kinds of control strategies can be converted into series of decentralized computing processes carried on by the smart nodes. The principle and mechanism of this decentralized, flat-structured control system for chiller plants are described in detail. Then a case study is presented to show how to build the decentralized, flat-structured control system actually. The measured data shows that the decentralized control method is energy efficiency. Moreover, it is much more flexible and scalable compared with the traditional centralized control method.

SPRY4-IT1 has been reported to have extremely high expression in normal placenta tissues. It is a Long noncoding RNA (lncRNA), which is associated with cell growth, migration, invasion, and apoptosis in melanoma. A 2.8-fold increase of SPRY4-IT1 expression was validated by Real-time reverse transcription-polymerase chain reaction (qRT-PCR) in severe preeclamptic placenta as compared with that of the normal ones (n=25) in this study. Furthermore, the role of SPRY4-IT1 in proliferation, migration, apoptosis, and network formation ability of trophoblast cells HTR-8/SVneo was assessed. Suppression of SPRY4-IT1 using siRNA treatment and its overexpression using plasmid targeting SPRY4-IT1 were performed in order to explore the biological function of SPRY4-IT1 in the development and progression of trophoblast cells HTR-8/SVneo, in vitro. The results showed that SPRY4-IT1 knockdown enhanced the cell migration and proliferation, and reduced the response of cells to apoptosis. However, exogenous SPRY4-IT1 overexpression significantly decreased the cell migration and proliferation, while increased cell apoptosis. Our study showed for the first time that aberrant expression of lncRNA SPRY4-IT1 might contribute to the abnormal condition of trophoblast cells HTR-8/SVneo. Therefore, we proposed SPRY4-IT1 as a novel lncRNA molecule, which might be associated with the pathogenesis of preeclampsia and might provide a new target for its early diagnosis and treatment.