101. Acoustoelectric imaging of time-varying current produced by a clinical deep brain stimulator
- Author
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Yexian Qin, Alex Burton, Pier Ingram, Russell S. Witte, Chet Preston, and Willard S. Kasoff
- Subjects
Materials science ,Deep brain stimulation ,business.industry ,medicine.medical_treatment ,0206 medical engineering ,Ultrasound ,Electrical engineering ,02 engineering and technology ,Current source ,020601 biomedical engineering ,Deep brain stimulator ,03 medical and health sciences ,0302 clinical medicine ,Transducer ,medicine ,Current (fluid) ,business ,Current density ,Pulse echo ,030217 neurology & neurosurgery ,Biomedical engineering - Abstract
Deep brain stimulation (DBS) is an effective treatment for a variety of brain disorders, including Parkinson's disease, depression and chronic pain. However, there is no reliable method to non-invasively image electric current flow generated by a DBS. In this study, we demonstrate 4D current source density imaging based on the acoustoelectric (AE) effect, which integrates an ultrasound beam with electrical recording, to map current flow produced by a clinical DBS device. AE imaging was able to accurately determine the polarity, magnitude and location of the current densities near the DBS device placed in physiologic saline with a signal-to-noise ratio of 17.1 dB using stimulation parameters similar to what are used on patients. Pulse echo (PE) ultrasound was acquired simultaneously to provide additional information regarding the spatial coordinates and structure of the DBS without need of additional techniques. These results suggest that AE imaging combined with PE ultrasound may provide valuable feedback during and after implantation of a DBS device.
- Published
- 2017
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