101. COCHLEAR HAIR CELL REGENERATION BASED ON STEM CELLS: A SYSTEMATIC REVIEW.
- Author
-
Costa, Vítor Bruno, Tomé, David, Yağmur Çirtlik, Zeynep, Öztürk, Yaren, Clemêncio, Filomena, and Pitt-Byrne, Theresa
- Subjects
- *
STEM cell transplantation , *GENE therapy , *SENSORINEURAL hearing loss , *CELLULAR therapy , *CELLULAR signal transduction , *REGENERATION (Biology) , *SYSTEMATIC reviews , *MEDLINE , *INNER ear , *STEM cells , *ONLINE information services , *COCHLEA , *HAIR cells , *MEDICAL care costs - Abstract
Introduction: According to the World Health Organization (WHO), by 2050 at least 700 million people will need access to hearing care and hearing rehabilitation services. The search for cell or gene therapies has been intensifying, and stem cell therapy looks a promising candidate to support hearing regeneration and reduce these numbers. The aim of this study is to provide an overview of current advances in stem cell-based therapies for cochlear hair cell regeneration and the processes being developed for future applicability. Material and methods: Identification and review of all articles in the databases PubMed, Web of Science, and PLoS One using the terms stem cell, auditory hair cell regeneration, and mammalian during February 2023 and following the PRISMA guidelines. Results: 50 articles were obtained, published between 2003 and 2022 and were systematically analyzed. The current research quantity is limited and further studies are needed, particularly in human tissue. Conclusion: The simultaneous use of cell therapy and gene therapy may lead to more promising results. Moreover, advances in cochlear hair cell regeneration with stem cells suggest there is a realistic potential to make the technique a useful future therapy. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF