1401. [Ingredients of Shuanghuanglian injection powder permeation through placental barrier of rat in pregnancy].
- Author
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Song D, Guo J, Wang Y, Pan G, Li P, Zhang W, and Song H
- Subjects
- Animals, Drugs, Chinese Herbal administration & dosage, Drugs, Chinese Herbal analysis, Female, Humans, Injections, Male, Models, Animal, Permeability, Placenta drug effects, Pregnancy, Rats, Rats, Wistar, Drugs, Chinese Herbal metabolism, Placenta metabolism
- Abstract
Objective: Use HPLC to study the permeation of ingredients of Shuanghuanglian injection powder (SHL) through placental barriers of rats at different stages of pregnancy., Method: The pregnant rats were administered SHL for 5 d through caudalis vena at different stages of pregnancy. Plasma and embryonic tissues were obtained 12 h after the final administration of SHL. The componds in biological specimen were identified by HPLC., Result: Baicalin, luteolin and wogonoside were the main compounds in plasma. Wogonoside retained in first trimester embryonic tissues, and baicalin retained in the embryonic tissues of different pregnant stages., Conclusion: Baicalin is the main compound of SHL through placental barriers of rats. Embryotoxicity of baicalin should be considered as the key point to evaluate the safety of SHL.
- Published
- 2010
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