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151. CRISPR-Cas9 engineering of the RAG2 locus via complete coding sequence replacement for therapeutic applications

Author

Daniel Allen, Orli Knop, Bryan Itkowitz, Nechama Kalter, Michael Rosenberg, Ortal Iancu, Katia Beider, Yu Nee Lee, Arnon Nagler, Raz Somech, and Ayal Hendel

Subjects
Science
Abstract

Abstract RAG2-SCID is a primary immunodeficiency caused by mutations in Recombination-activating gene 2 (RAG2), a gene intimately involved in the process of lymphocyte maturation and function. ex-vivo manipulation of a patient’s own hematopoietic stem and progenitor cells (HSPCs) using CRISPR-Cas9/rAAV6 gene editing could provide a therapeutic alternative to the only current treatment, allogeneic hematopoietic stem cell transplantation (HSCT). Here we show an innovative RAG2 correction strategy that replaces the entire endogenous coding sequence (CDS) for the purpose of preserving the critical endogenous spatiotemporal gene regulation and locus architecture. Expression of the corrective transgene leads to successful development into CD3+TCRαβ+ and CD3+TCRγδ+ T cells and promotes the establishment of highly diverse TRB and TRG repertoires in an in-vitro T-cell differentiation platform. Thus, our proof-of-concept study holds promise for safer gene therapy techniques of tightly regulated genes.

Published
2023
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152. Simultaneous bright- and dark-field X-ray microscopy at X-ray free electron lasers

Author

Leora E. Dresselhaus-Marais, Bernard Kozioziemski, Theodor S. Holstad, Trygve Magnus Ræder, Matthew Seaberg, Daewoong Nam, Sangsoo Kim, Sean Breckling, Sungwook Choi, Matthieu Chollet, Philip K. Cook, Eric Folsom, Eric Galtier, Arnulfo Gonzalez, Tais Gorkhover, Serge Guillet, Kristoffer Haldrup, Marylesa Howard, Kento Katagiri, Seonghan Kim, Sunam Kim, Sungwon Kim, Hyunjung Kim, Erik Bergbäck Knudsen, Stephan Kuschel, Hae Ja Lee, Chuanlong Lin, R. Stewart McWilliams, Bob Nagler, Martin Meedom Nielsen, Norimasa Ozaki, Dayeeta Pal, Ricardo Pablo Pedro, Alison M. Saunders, Frank Schoofs, Toshimori Sekine, Hugh Simons, Tim van Driel, Bihan Wang, Wenge Yang, Can Yildirim, Henning Friis Poulsen, and Jon H. Eggert

Subjects
Medicine, Science
Abstract

Abstract The structures, strain fields, and defect distributions in solid materials underlie the mechanical and physical properties across numerous applications. Many modern microstructural microscopy tools characterize crystal grains, domains and defects required to map lattice distortions or deformation, but are limited to studies of the (near) surface. Generally speaking, such tools cannot probe the structural dynamics in a way that is representative of bulk behavior. Synchrotron X-ray diffraction based imaging has long mapped the deeply embedded structural elements, and with enhanced resolution, dark field X-ray microscopy (DFXM) can now map those features with the requisite nm-resolution. However, these techniques still suffer from the required integration times due to limitations from the source and optics. This work extends DFXM to X-ray free electron lasers, showing how the $$10^{12}$$ 10 12 photons per pulse available at these sources offer structural characterization down to 100 fs resolution (orders of magnitude faster than current synchrotron images). We introduce the XFEL DFXM setup with simultaneous bright field microscopy to probe density changes within the same volume. This work presents a comprehensive guide to the multi-modal ultrafast high-resolution X-ray microscope that we constructed and tested at two XFELs, and shows initial data demonstrating two timing strategies to study associated reversible or irreversible lattice dynamics.

Published
2023
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153. Allogeneic hematopoietic cell transplantation for patients with AML aged 70 years or older in first remission. A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Maffini, Enrico, Ngoya, Maud, Galimard, Jacques-Emmanuel, Harbi, Samia, Kröger, Nicolaus, Platzbecker, Uwe, Sengeloev, Henrik, Craddock, Charles, Potter, Victoria, Choi, Goda, Chevallier, Patrice, Stölzel, Friedrich, Tholouli, Eleni, Maertens, Johan, Ciceri, Fabio, Cornelissen, Jan, Sanz, Jaime, Spyridonidis, Alexandros, Lanza, Francesco, Nagler, Arnon, and Mohty, Mohamad

Published
2023
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154. Long-term outcome of second allogeneic hematopoietic stem cell transplantation (HSCT2) for primary graft failure in patients with acute leukemia in remission: A study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Swoboda, Ryszard, Kulagin, Alexander, Velardi, Andrea, Sanz, Jaime, Labussière-Wallet, Hélène, Potter, Victoria, Kuball, Jürgen, Sica, Simona, Parovichnikova, Elena, Bethge, Wolfgang, Maillard, Natacha, Platzbecker, Uwe, Stölzel, Friedrich, Ciceri, Fabio, and Mohty, Mohamad

Published
2023
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155. Second haploidentical stem cell transplantation (HAPLO-SCT2) after relapse from a first HAPLO-SCT in acute leukaemia—a study on behalf of the Acute Leukaemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Filippini Velázquez, Giuliano, Labopin, Myriam, Tischer, Johanna, Raiola, Anna Maria, Angelucci, Emanuele, Kulagin, Alexander D., Galieni, Piero, Bermúdez, Arancha, Bulabois, Claude-Eric, Kröger, Nicolaus, Díez-Martín, José Luis, Kwon, Mi, Nagler, Arnon, Schmid, Christoph, Ciceri, Fabio, and Mohty, Mohamad

Published
2023
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156. Total body irradiation versus busulfan based intermediate intensity conditioning for stem cell transplantation in ALL patients >45 years—a registry-based study by the Acute Leukemia Working Party of the EBMT

Author

Hirschbühl, Klaus, Labopin, Myriam, Polge, Emmanuelle, Blaise, Didier, Bourhis, Jean Henri, Socié, Gerard, Forcade, Edouard, Yakoub-Agha, Ibrahim, Labussière-Wallet, Hélène, Bethge, Wolfgang, Chevallier, Patrice, Bonnet, Sarah, Stelljes, Matthias, Spyridonidis, Alexandros, Peric, Zinaida, Brissot, Eolia, Savani, Bipin, Giebel, Sebastian, Schmid, Christoph, Ciceri, Fabio, Nagler, Arnon, and Mohty, Mohamad

Published
2023
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159. Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a refined classification from the European society for blood and marrow transplantation (EBMT)

Author

Mohty, Mohamad, Malard, Florent, Alaskar, Ahmed S., Aljurf, Mahmoud, Arat, Mutlu, Bader, Peter, Baron, Frederic, Bazarbachi, Ali, Blaise, Didier, Brissot, Eolia, Ciceri, Fabio, Corbacioglu, Selim, Dalle, Jean-Hugues, Dignan, Fiona, Huynh, Anne, Kenyon, Michelle, Nagler, Arnon, Pagliuca, Antonio, Perić, Zinaida, Richardson, Paul G., Ruggeri, Annalisa, Ruutu, Tapani, Yakoub-Agha, Ibrahim, Duarte, Rafael F., and Carreras, Enric

Published
2023
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160. Matched related versus unrelated versus haploidentical donors for allogeneic transplantation in AML patients achieving first complete remission after two induction courses: a study from the ALWP/EBMT

Author

Nagler, Arnon, Labopin, Myriam, Mielke, Stephan, Passweg, Jakob, Blaise, Didier, Gedde-Dahl, Tobias, Cornelissen, Jan J., Salmenniemi, Urpu, Yakoub-Agha, Ibrahim, Reményi, Péter, Socié, Gerard, van Gorkom, Gwendolyn, Labussière-Wallet, Hélène, Huang, Xiao-Jun, Rubio, Marie Thérèse, Byrne, Jenny, Craddock, Charles, Griškevičius, Laimonas, Ciceri, Fabio, and Mohty, Mohamad

Published
2023
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161. Impact of disease burden on clinical outcomes of AML patients receiving allogeneic hematopoietic cell transplantation: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Abou Dalle, Iman, Labopin, Myriam, Kröger, Nicolaus, Schroeder, Thomas, Finke, Jürgen, Stelljes, Matthias, Neubauer, Andreas, Blaise, Didier, Yakoub-Agha, Ibrahim, Salmenniemi, Urpu, Forcade, Edouard, Itäla-Remes, Maija, Dreger, Peter, Bug, Gesine, Passweg, Jakob, Heuser, Michael, Choi, Goda, Brissot, Eolia, Giebel, Sebastian, Nagler, Arnon, Ciceri, Fabio, Bazarbachi, Ali, and Mohty, Mohamad

Published
2023
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163. Risk factors for Nocardia infection among allogeneic hematopoietic cell transplant recipients: A case-control study of the Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation

Author

De Greef, Julien, Averbuch, Dina, Tondeur, Laura, Duréault, Amélie, Zuckerman, Tsila, Roussel, Xavier, Robin, Christine, Xhaard, Alienor, Pagliuca, Simona, Beguin, Yves, Botella-Garcia, Carmen, Khanna, Nina, Le Bourgeois, Amandine, Van Praet, Jens, Ho, Aloysius, Kröger, Nicolaus, Ducastelle Leprêtre, Sophie, Roos-Weil, Damien, Aljurf, Mahmoud, Blijlevens, Nicole, Blau, Igor Wolfgang, Carlson, Kristina, Collin, Matthew, Ganser, Arnold, Villate, Alban, Lakner, Johannes, Martin, Sonja, Nagler, Arnon, Ram, Ron, Torrent, Anna, Stamouli, Maria, Mikulska, Malgorzata, Gil, Lidia, Wendel, Lotus, Tridello, Gloria, Knelange, Nina, de la Camara, Rafael, Lortholary, Olivier, Fontanet, Arnaud, Styczynski, Jan, Maertens, Johan, Coussement, Julien, and Lebeaux, David

Published
2024
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164. Haploidentical stem cell donor choice for patients with acute myeloid leukemia: a study from the ALWP of the EBMT

Author

Sanz, Jaime, Labopin, Myriam, Blaise, Didier, Raiola, Anna Maria, Busca, Alessandro, Vydra, Jan, Tischer, Johanna, Chevallier, Patrice, Bramanti, Stefania, Fanin, Renato, Socié, Gérard, Forcade, Edouard, Kröger, Nicolaus, Koc, Yener, Itäla-Remes, Maija, Zecca, Marco, Nagler, Arnon, Brissot, Eolia, Spyridonidis, Alexandros, Bazarbachi, Ali, Giebel, Sebastian, Piemontese, Simona, Mohty, Mohamad, and Ciceri, Fabio

Published
2024
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166. Anticoagulation with argatroban using hemoclot™ targets is safe and effective in CARDS patients receiving venovenous extracorporeal membrane oxygenation: An exploratory bi-centric cohort study

Author

Mayerhöfer, Timo, Joannidis, Michael, Peer, Andreas, Perschinka, Fabian, Fries, Dietmar, Mair, Peter, Gasteiger, Lukas, Bachler, Mirjam, Kilo, Juliane, Herkner, Harald, Schwameis, Michael, Schellongowski, Peter, Nagler, Bernhard, Kornfehl, Andrea, Staudinger, Thomas, and Buchtele, Nina

Published
2024
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167. Impact of the COVID-19 pandemic on surgical trainee education and well-being spring 2020-winter 2020: A path forward

Author

Ellison, E Christopher, Nagler, Alisa, Stain, Steven C, Matthews, Jeffrey B, Spanknebel, Kathryn, Shabahang, Mohsen M, Blair, Patrice Gabler, Farmer, Diana L, Sloane, Richard, Britt, LD, and Sachdeva, Ajit K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Quality Education, COVID-19, Communicable Disease Control, Education, Medical, Humans, Learning, Pandemics, Specialties, Surgical, Surveys and Questionnaires, United States, COVID-19 pandemic, ACGME emergency declaration, Surgical educational programs, Learner well-being, Learner wellness, Surgery, Clinical sciences, Dentistry
Abstract

BackgroundThe time course and longitudinal impact of the COVID -19 pandemic on surgical education(SE) and learner well-being (LWB)is unknown.Material and methodsCheck-in surveys were distributed to Surgery Program Directors and Department Chairs, including general surgery and surgical specialties, in the summer and winter of 2020 and compared to a survey from spring 2020. Statistical associations for items with self-reported ACGME Stage and the survey period were assessed using categorical analysis.ResultsStage 3 institutions were reported in spring (30%), summer (4%) [p

Published
2022

168. Atomistic deformation mechanism of silicon under laser-driven shock compression

Author

Pandolfi, S., Brown, S. Brennan, Stubley, P. G., Higginbotham, A., Bolme, C. A., Lee, H. J., Nagler, B., Galtier, E., Sandberg, R., Yang, W., Mao, W. L., Wark, J. S., and Gleason, A.

Subjects
Condensed Matter - Materials Science
Abstract

Silicon (Si) is one of the most abundant elements on Earth, and it is the most important and widely used semiconductor, constituting the basis of modern electronic devices. Despite extensive study, some properties of Si remain elusive. For example, the behaviour of Si under high pressure, in particular at the ultra-high strain rates characteristic of dynamic compression, has been a matter of debate for decades. A detailed understanding of how Si deforms is crucial for a variety of fields, ranging from planetary science to materials design. Simulations suggest that in Si the shear stress generated during shock compression is released inelastically, i.e., via a high-pressure phase transition, challenging the classical picture of relaxation via defect-mediated plasticity. However, experiments at the short timescales characteristic of shock compression are challenging, and direct evidence supporting either deformation mechanism remain elusive. Here, we use sub-picosecond, highly-monochromatic x-ray diffraction to study (100)-oriented single-crystal Si under laser-driven shock compression. We provide the first unambiguous, time-resolved picture of Si deformation at ultra-high strain rates, demonstrating the predicted inelastic shear release. Our results resolve the longstanding controversy on silicon deformation under dynamic compression, and provide direct proof of strain rate-dependent deformation mechanisms in a non-metallic system, which is key for the study of planetary-relevant materials.

Published
2021
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169. Ultrafast charge-transfer dynamics in twisted MoS$_2$/WSe$_2$ heterostructures

Author

Zimmermann, J. E., Axt, M., Mooshammer, F., Nagler, P., Schüller, C., Korn, T., Höfer, U., and Mette, G.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Two-dimensional transition metal dichalcogenides (TMD) offer a unique platform for creating van-der-Waals heterojunctions with fascinating physical properties and promising applications in optoelectronics and valleytronics. Because of their typical type-II band alignment, photoexcited electrons and holes can separate via interfacial charge transfer. To understand the nature and the dynamics of this charge transfer is of utmost importance for the design and efficiency of potential devices. However, systematic studies concerning the influence of the stacking angle on the charge transfer remain sparse. Here, we apply time- and polarization resolved second-harmonic imaging microscopy to investigate the charge-transfer dynamics for three MoS$_2$/WSe$_2$ heterostructures with different stacking angles at a previously unattainable time-resolution of $\approx$ 6 fs. For 1.70 eV excitation energy, electron transfer from WSe$_2$ to MoS$_2$ is found to depend considerably on the stacking angle with the fastest transfer time observed to be as short as 12 fs. At 1.85 eV excitation energy, ultrafast hole transfer from MoS$_2$ to hybridized states at the $\Gamma$-point or to the K-points of WSe$_2$ has to be considered. Surprisingly, the corresponding decay dynamics show only a minor stacking-angle dependence indicating that radiative recombination of indirect $\Gamma$-K excitons becomes the dominant decay route for all samples.

Published
2021
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170. Oscillations of the thermal conductivity observed in the spin-liquid state of $\alpha$-RuCl$_3$

Author

Czajka, Peter, Gao, Tong, Hirschberger, Max, Lampen-Kelley, Paula, Banerjee, Arnab, Yan, Jiaqiang, Mandrus, David G., Nagler, Stephen E., and Ong, N. P.

Subjects
Condensed Matter - Strongly Correlated Electrons
Abstract

In the class of materials called spin liquids, a magnetically ordered state cannot be attained even at milliKelvin temperatures because of conflicting constraints on each spin (for e.g. from geometric or exchange frustration). The resulting quantum spin-liquid (QSL) state is currently of intense interest because it exhibits novel excitations as well as wave-function entanglement. The layered insulator $\alpha$-RuCl$_3$ orders as a zigzag antiferromagnet below $\sim$7 K in zero magnetic field. The zigzag order is destroyed when a magnetic field $\bf H$ is applied parallel to the zigzag axis a. Within the field interval (7.3, 11) Tesla, there is growing evidence that a QSL state exists. Here we report the observation of oscillations in its thermal conductivity below 4 K. The oscillation amplitude is very large within the interval (7.3, 11) T and strongly suppressed on either side. Paradoxically, the oscillations are periodic in 1/\emph{H}, analogous to quantum oscillations in metals, even though $\alpha$-RuCl$_3$ is an excellent insulator with a gap of 1.9 eV. By tilting $\bf H$ out of the plane, we find that the oscillation period is determined by the in-plane component $H_a$. As the temperature is raised above 0.5 K, the oscillation amplitude decreases exponentially. The decrease anticorrelates with the emergence above $\sim$2 K of an anomalous planar thermal Hall conductivity measured with $\bf H\parallel a$. To exclude extrinsic artifacts, we carried out several tests. The implications of the oscillations are discussed., Comment: 8 pages, 3 figures

Published
2021
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171. Witnessing entanglement in quantum magnets using neutron scattering

Author

Scheie, A., Laurell, Pontus, Samarakoon, A. M., Lake, B., Nagler, S. E., Granroth, G. E., Okamoto, S., Alvarez, G., and Tennant, D. A.

Subjects
Condensed Matter - Strongly Correlated Electrons, Quantum Physics
Abstract

We demonstrate how quantum entanglement can be directly witnessed in the quasi-1D Heisenberg antiferromagnet KCuF$_3$. We apply three entanglement witnesses --- one-tangle, two-tangle, and quantum Fisher information --- to its inelastic neutron spectrum, and compare with spectra simulated by finite-temperature density matrix renormalization group (DMRG) and classical Monte Carlo methods. We find that each witness provides direct access to entanglement. Of these, quantum Fisher information is the most robust experimentally, and indicates the presence of at least bipartite entanglement up to at least 50 K, corresponding to around 10% of the spinon zone-boundary energy. We apply quantum Fisher information to higher spin-S Heisenberg chains, and show theoretically that the witnessable entanglement gets suppressed to lower temperatures as the quantum number increases. Finally, we outline how these results can be applied to higher dimensional quantum materials to witness and quantify entanglement., Comment: 9 pages and 5 figures, four pages and six figures of appendices, and five pages supplemental information

Published
2021
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172. Explaining predictive models using Shapley values and non-parametric vine copulas

Author

Aas, Kjersti, Nagler, Thomas, Jullum, Martin, and Løland, Anders

Subjects
Statistics - Methodology, Computer Science - Machine Learning, Statistics - Machine Learning
Abstract

The original development of Shapley values for prediction explanation relied on the assumption that the features being described were independent. If the features in reality are dependent this may lead to incorrect explanations. Hence, there have recently been attempts of appropriately modelling/estimating the dependence between the features. Although the proposed methods clearly outperform the traditional approach assuming independence, they have their weaknesses. In this paper we propose two new approaches for modelling the dependence between the features. Both approaches are based on vine copulas, which are flexible tools for modelling multivariate non-Gaussian distributions able to characterise a wide range of complex dependencies. The performance of the proposed methods is evaluated on simulated data sets and a real data set. The experiments demonstrate that the vine copula approaches give more accurate approximations to the true Shapley values than its competitors.

Published
2021

173. Potential of the Bi-Static SAR Satellite Companion Mission Harmony for Land-Ice Observations

Author

Andreas Kääb, Jérémie Mouginot, Pau Prats-Iraola, Eric Rignot, Bernhard Rabus, Andreas Benedikter, Helmut Rott, Thomas Nagler, Björn Rommen, and Paco Lopez-Dekker

Subjects
synthetic aperture radar, bi-static, multi-static, satellite constellation, Science
Abstract

The EarthExplorer 10 mission Harmony by the European Space Agency ESA, scheduled for launch around 2029–2030, consists of two passive C-band synthetic-aperture-radar companion satellites flying in a flexible constellation with one Sentinel-1 radar satellite as an illuminator. Sentinel-1 will serve as transmitter and receiver of radar waves, and the two Harmonys will serve as bistatic receivers without the ability to transmit. During the first and last year of the 5-year mission, the two Harmony satellites will fly in a cross-track interferometric constellation, such as that known from TanDEM-X, about 350 km ahead or behind the assigned Sentinel-1. This constellation will provide 12-day repeat DEMs, among other regions, over most land-ice and permafrost areas. These repeat DEMs will be complemented by synchronous lateral terrain displacements from the well-established offset tracking method. In between the cross-track interferometry phases, one of the Harmony satellites will be moved to the opposite side of the Sentinel-1 to form a symmetric bistatic “stereo” constellation with ±~350 km along-track baseline. In this phase, the mission will provide opportunity for radar interferometry along three lines of sight, or up to six when combining ascending and descending acquisitions, enabling the measurement of three-dimensional surface motion, for instance sub- and emergence components of ice flow, or three-dimensional deformation of permafrost surfaces or slow landslides. Such measurements would, for the first time, be available for large areas and are anticipated to provide a number of novel insights into the dynamics and mass balance of a range of mass movement processes.

Published
2024
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174. On Connecting Hydrosocial Parameters to Vegetation Greenness Differences in an Evolving Groundwater-Dependent Ecosystem

Author

Matthew R. Lurtz, Ryan R. Morrison, and Pamela L. Nagler

Subjects
groundwater-dependent ecosystem, Bayesian framework, hierarchical modeling, autoregressive, Science
Abstract

Understanding groundwater-dependent ecosystems (i.e., areas with a relatively shallow water table that plays a major role in supporting vegetation health) is key to sustaining water resources in the western United States. Groundwater-dependent ecosystems (GDEs) in Colorado have non-pristine temporal and spatial patterns, compared to agro-ecosystems, which make it difficult to quantify how these ecosystems are impacted by changes in water availability. The goal of this study is to examine how key hydrosocial parameters perturb GDE water use in time and in space. The temporal approach tests for the additive impacts of precipitation, surface water discharge, surface water mass balance as a surrogate for surface–groundwater exchange, and groundwater depth on the monthly Landsat normalized difference vegetation index (NDVI). The spatial approach tests for the additive impacts of river confluences, canal augmentation, development, perennial tributary confluences, and farmland modification on temporally integrated NDVI. Model results show a temporal trend (monthly, 1984–2019) is identifiable along segments of the Arkansas River at resolutions finer than 10 km. The temporal impacts of river discharge correlate with riparian water use sooner in time compared to precipitation, but this result is spatially variable and dependent on the covariates tested. Spatially, areal segments of the Arkansas River that have confluences with perennial streams have increased cumulative vegetation density. Quantifying temporal and spatial dependencies between the sources and effects of GDEs could aid in preventing the loss of a vulnerable ecosystem to increased water demand, changing climate, and evolving irrigation methodologies.

Published
2024
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176. An Application of Large Language Models to Coding Negotiation Transcripts.

Author

Ray Friedman, Jaewoo Cho, Jeanne M. Brett, Xuhui Zhan, Ningyu Han, Sriram Kannan, Yingxiang Ma, Jesse Spencer-Smith, Elisabeth Jäckel, Alfred Zerres, Madison Hooper, Katie Babbit, Manish Acharya, Wendi L. Adair, Soroush Aslani, Tayfun Aykaç, Chris Bauman, Rebecca Bennett, Garrett Brady, Peggy Briggs, Cheryl Dowie, Chase Eck, Ingmar Geiger, Frank Jacob, Molly Kern, Sujin Lee, Leigh Anne Liu, Wu Liu, Jeffrey Loewenstein, Anne Lytle, Li Ma, Michel Mann, Alexandra Mislin, Tyree Mitchell, Hannah Martensen née Nagler, Amit Nandkeolyar, Mara Olekalns, Elena Paliakova, Jennifer Parlamis, Jason Pierce, Nancy Pierce, Robin Pinkley, Nathalie Prime, Jimena Ramirez-Marin, Kevin Rockmann, William Ross, Zhaleh Semnani-Azad, Juliana Schroeder, Philip Smith, Elena Stimmer, Roderick Swaab, Leigh Thompson, Cathy Tinsley, Ece Tuncel, Laurie R. Weingart, Robert Wilken, JingJing Yao, and Zhi-Xue Zhang

Published
2024
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184. Digital Transformation of Teaching and Perception at TU Graz from the Students’ Perspective: Developments from the Last 17 Years

Author

Ebner, Martin, Mair, Bettina, De Marinis, Christoph, Müller, Hannes, Nagler, Walther, Schön, Sandra, Thurner, Stefan, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Auer, Michael E., editor, Pachatz, Wolfgang, editor, and Rüütmann, Tiia, editor

Published
2023
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185. Systematic evaluation of donor-KIR/recipient-HLA interactions in HLA-matched hematopoietic cell transplantation for AML

Author

Fein, Joshua A., Shouval, Roni, Krieger, Elizabeth, Spellman, Stephen R., Wang, Tao, Baldauf, Henning, Fleischhauer, Katharina, Kröger, Nicolaus, Horowitz, Mary, Maiers, Martin, Miller, Jeffrey S, Mohty, Mohamad, Nagler, Arnon, Weisdorf, Daniel, Malmberg, Karl-Johan, Toor, Amir A., Schetelig, Johannes, Romee, Rizwan, and Koreth, John

Published
2024
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186. Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation

Author

Penack, Olaf, Marchetti, Monia, Aljurf, Mahmoud, Arat, Mutlu, Bonifazi, Francesca, Duarte, Rafael F, Giebel, Sebastian, Greinix, Hildegard, Hazenberg, Mette D, Kröger, Nicolaus, Mielke, Stephan, Mohty, Mohamad, Nagler, Arnon, Passweg, Jakob, Patriarca, Francesca, Ruutu, Tapani, Schoemans, Hélène, Solano, Carlos, Vrhovac, Radovan, Wolff, Daniel, Zeiser, Robert, Sureda, Anna, and Peric, Zinaida

Published
2024
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190. Impact of the Type of Tyrosine Kinase Inhibitor (imatinib or dasatinib) Used Before allo-HCT on Outcome of Patients with Philadelphia-Positive Acute Lymphoblastic Leukemia. A Study on Behalf of the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Peric, Zinaida, Passweg, Jakob, Blaise, Didier, Salmenniemi, Urpu, Beauvais, David, Reményi, Péter, Chevallier, Patrice, Mielke, Stephan, Gedde-Dahl, Tobias, Cornelissen, Jan J., Balsat, Marie, Bug, Gesine, Bazarbachi, Ali, Brissot, Eolia, Nagler, Arnon, Ciceri, Fabio, and Mohty, Mohamad

Published
2024
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191. Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction

Author

Todd, Jamie L., Weber, Jeremy M., Kelly, Francine L., Nagler, Andrew, McArthur, Patrick, Eason, Lerin, Rim, Jeeyon G., Frankel, Courtney W., Belperio, John A., Budev, Marie, Martinu, Tereza, Patel, Kunal, Reynolds, John M., Shah, Pali D., Singer, Lianne G., Snyder, Laurie D., Tsuang, Wayne, Weigt, S. Sam, Neely, Megan L., and Palmer, Scott M.

Published
2024
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192. Fludarabine or cyclophosphamide in combination with total body irradiation as myeloablative conditioning prior to allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the EBMT

Author

Giebel, Sebastian, Labopin, Myriam, Socié, Gerard, Aljurf, Mahmoud, Salmenniemi, Urpu, Labussière-Wallet, Hélène, Srour, Micha, Kröger, Nicolaus, Zahrani, Mohsen Al, Lioure, Bruno, Reményi, Péter, Arat, Mutlu, Bourhis, Jean Henri, Helbig, Grzegorz, Tbakhi, Abdelghani, Forcade, Edouard, Huynh, Anne, Brissot, Eolia, Spirydonidis, Alexandros, Savani, Bipin N., Peric, Zinaida, Nagler, Arnon, and Mohty, Mohamad

Published
2023
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193. Allogeneic stem cell transplantation for patients with acute myeloid leukemia (AML) in second complete remission (CR2) transplanted from unrelated donors with post-transplant cyclophosphamide (PTCy). A study on behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Nagler, Arnon, Labopin, Myriam, Swoboda, Ryszard, Kulagin, Alexander, Labussière-Wallet, Hélène, Rovira, Montserrat, Blaise, Didier, Vydra, Jan, Yakoub-Agha, Ibrahim, Choi, Goda, Reményi, Péter, Koc, Yener, Sanz, Jaime, Ciceri, Fabio, and Mohty, Mohamad

Published
2023
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194. Autologous versus allogeneic hematopoietic cell transplantation for older patients with acute lymphoblastic leukemia. An analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Giebel, Sebastian, Labopin, Myriam, Houhou, Mohamed, Caillot, Denis, Finke, Jürgen, Blaise, Didier, Fegueux, Nathalie, Ethell, Mark, Cornelissen, Jan J., Forcade, Edouard, Yakoub-Agha, Ibrahim, Lussana, Federico, Maertens, Johan, Bourhis, Jean Henri, Jindra, Pavel, Gorin, Norbert Claude, Nagler, Arnon, and Mohty, Mohamad

Published
2023
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195. Correlation of Peripheral Chimeric Antigen Receptor T-cell (CAR-T Cell) mRNA Expression Levels with Toxicities and Outcomes in Patients with Diffuse Large B-cell Lymphoma

Author

Christian Messerli, Gertrud Wiedemann, Naomi Porret, Michael Nagler, Katja Seipel, Barbara Jeker, Urban Novak, Sacha Zeerleder, Ulrike Bacher, and Thomas Pabst

Subjects
non-hodgkin lymphoma, lymphomas, neoplasia, transplant-related toxicity, stem cell transplantation, molecular biology, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) are significant complications in patients with relapsed/refractory diffuse large B-cell lymphoma undergoing chimeric antigen receptor T-cell (CAR-T cell) therapy. However, it remains unclear whether CAR-T cell expression itself is clinically relevant. We assessed CAR-T cell mRNA expression and DNA concentration by digital droplet PCR in peripheral blood from 14 sequential CAR-T cell recipients. Patients were grouped according to CAR-T cell peak expression. Patients with high CAR-T cell peak expression (8 patients; 57%) had higher rates of ICANS (p=0.0308) and intensive care unit admission (p=0.0404), longer durations of hospitalization (p=0.0077), and, although not statistically significant, a higher rate of CRS (p=0.0778). There was a correlation of CAR-T cell mRNA expression with DNA concentration, but CAR-T cell expression levels failed to correlate to response or survival. Our data suggest that higher CAR-T cell peak mRNA expression is associated with increased risk for ICANS and possibly CRS, requiring further investigation in larger studies.

Published
2023
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196. Incidence and outcome of central nervous system relapse after hematopoietic stem cell transplantation in patients suffering from acute myeloid leukemia and acute lymphoblastic leukemia: a study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Author

Sabine Blum, Yves Chalandon, Myriam Labopin, Jürgen Finke, Tobias Gedde-Dahl, Tarek Ben Othman, Jan J. Cornelissen, Pavel Jindra, Hélène Labussière-Wallet, Matthew Collin, Stig Lenhoff, Guido Kobbe, Norma C. Gutiérrez, Arnon Nagler, and Mohamad Mohty

Subjects
Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Not available.

Published
2024
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197. Evolving Digital Skills of first-year students: A Pre- and Post-Covid Analysis

Author

Martin Ebner, Bettina Mair, Walther Nagler, Sandra Schön, and Sarah Edelsbrunner

Subjects
Education
Abstract

Digital skills are necessary for first-year students at Austrian universities. This paper unveils results from two surveys among first-year students at Graz University of Technology (TU Graz): Pre-Covid-19 data (n=921) is derived from a larger study on digital literacy among first-year students in Styria (Janschitz et al., 2021, N=4,676). The same questions were posed in the 2021 ‘Welcome Days’ survey after the Covid-19 distance learning phases (n=1,207). Surprisingly, the only significant change is a noticeable increase of skills concerning the digital signature. This article additionally presents the development of a lecture on digital skills that was implemented at TU Graz as a massive open online course (MOOC).

Published
2024
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199. Field-induced intermediate ordered phase and anisotropic interlayer interactions in $\alpha$-RuCl$_3$

Author

Balz, Christian, Janssen, Lukas, Lampen-Kelley, Paula, Banerjee, Arnab, Liu, Yaohua, Yan, Jiaqiang, Mandrus, David, Vojta, Matthias, and Nagler, Stephen E.

Subjects
Condensed Matter - Strongly Correlated Electrons, Condensed Matter - Materials Science
Abstract

In $\alpha$-RuCl$_3$, an external magnetic field applied within the honeycomb plane can induce a transition from a magnetically ordered state to a disordered state that is potentially related to the Kitaev quantum spin liquid. In zero field, single crystals with minimal stacking faults display a low-temperature state with in-plane zigzag antiferromagnetic order and a three-layer periodicity in the direction perpendicular to the honeycomb planes. Here, we present angle-dependent magnetization, ac susceptibility, and thermal transport data that demonstrate the presence of an additional intermediate-field ordered state at fields below the transition to the disordered phase. Neutron diffraction results show that the magnetic structure in this phase is characterized by a six-layer periodicity in the direction perpendicular to the honeycomb planes. Theoretically, the intermediate ordered phase can be accounted for by including spin-anisotropic couplings between the layers in a three-dimensional spin model. Together, this demonstrates the importance of interlayer exchange interactions in $\alpha$-RuCl$_3$., Comment: This article supersedes arXiv:1807.06192 which proposed that the intermediate-field ordered phase displays an in-plane magnetic order different from zigzag

Published
2020
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200. Copula-based synthetic data augmentation for machine-learning emulators

Author

Meyer, David, Nagler, Thomas, and Hogan, Robin J.

Subjects
Computer Science - Machine Learning, Physics - Atmospheric and Oceanic Physics
Abstract

Can we improve machine-learning (ML) emulators with synthetic data? If data are scarce or expensive to source and a physical model is available, statistically generated data may be useful for augmenting training sets cheaply. Here we explore the use of copula-based models for generating synthetically augmented datasets in weather and climate by testing the method on a toy physical model of downwelling longwave radiation and corresponding neural network emulator. Results show that for copula-augmented datasets, predictions are improved by up to 62 % for the mean absolute error (from 1.17 to 0.44 W m$^{-2}$)., Comment: Published version

Published
2020
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