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4,964 results on '"Angel, J"'

152. Structure–Activity Relationship of Pyrrolidine Pentamine Derivatives as Inhibitors of the Aminoglycoside 6′- N -Acetyltransferase Type Ib.

Author

Sklenicka, Jan, Tran, Tung, Ramirez, Maria S., Donow, Haley M., Magaña, Angel J., LaVoi, Travis, Mamun, Yasir, Jimenez, Verónica, Chapagain, Prem, Santos, Radleigh, Pinilla, Clemencia, Giulianotti, Marc A., and Tolmasky, Marcelo E.

Subjects
SMALL molecules, STEREOCHEMISTRY, GRAM-negative bacteria, MOLECULAR docking, DRUG development, AMIKACIN
Abstract

Resistance to amikacin and other major aminoglycosides is commonly due to enzymatic acetylation by the aminoglycoside 6′-N-acetyltransferase type I enzyme, of which type Ib [AAC(6′)-Ib] is the most widespread among Gram-negative pathogens. Finding enzymatic inhibitors could be an effective way to overcome resistance and extend the useful life of amikacin. Small molecules possess multiple properties that make them attractive for drug development. Mixture-based combinatorial libraries and positional scanning strategy have led to the identification of a chemical scaffold, pyrrolidine pentamine, that, when substituted with the appropriate functionalities at five locations (R1–R5), inhibits AAC(6′)-Ib-mediated inactivation of amikacin. Structure–activity relationship studies have shown that while truncations to the molecule result in loss of inhibitory activity, modifications of functionalities and stereochemistry have different effects on the inhibitory properties. In this study, we show that alterations at position R1 of the two most active compounds, 2700.001 and 2700.003, reduced inhibition levels, demonstrating the essential nature not only of the presence of an S-phenyl moiety at this location but also the distance to the scaffold. On the other hand, modifications on the R3, R4, and R5 positions had varied effects, demonstrating the potential for optimization. A correlation analysis between molecular docking values (ΔG) and the dose required for two-fold potentiation of the compounds described in this and the previous studies showed a significant correlation between ΔG values and inhibitory activity. [ABSTRACT FROM AUTHOR]

Published
2024
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153. Optimizing Landfill Site Selection Using Fuzzy-AHP and GIS for Sustainable Urban Planning.

Author

Zabaleta Santisteban, Jhon Antony, López, Rolando Salas, Rojas-Briceño, Nilton B., Fernández, Darwin Gómez, Medina Medina, Angel J., Tuesta Trauco, Katerin M., Rivera Fernandez, Abner S., Crisóstomo, José Lévano, Oliva-Cruz, Manuel, and Silva-López, Jhonsy O.

Subjects
GEOGRAPHIC information systems, WASTE management, SOLID waste, POPULATION forecasting, URBAN planning
Abstract

Careful landfill selection with minimal environmental impact is vital for urban planners. This study aims to identify suitable sites for controlled landfills using Fuzzy-AHP integrated with Remote Sensing and GIS, considering a 20-year projection of population and solid waste generation. Initially, twelve sub-criteria were identified, grouped into environmental, socioeconomic, and physical categories, and then weighted using paired comparison matrices involving nine experts. The subcriteria were rasterized and classified into four suitability levels. The weighted overlay of sub-criteria maps generated a territorial suitability model. Within the Alto Utcubamba Commonwealth (Amazonas, Peru), 0.069%, 41.70%, 66.934%, 0.20%, and 12.4% of the territory are suitable, moderately suitable, less suitable, unsuitable, and restricted, respectively, for landfill establishment. Subsequently, 16 highly suitable sites were selected based on the required area (S4 polygons ≥ 0.505 ha) in line with the projected solid waste generation over 20 years. Of the 16 selected areas, only 15 met the shape index. The model showed high accuracy (AUC = 0.784) during validation. Furthermore, this study provides a comprehensive framework for making decisions about waste management in developing countries, enhancing understanding of key factors in selecting landfill sites. It also offers a deeper insight into global and local factors that determine the suitability of landfill sites. [ABSTRACT FROM AUTHOR]

Published
2024
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157. Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17

Author

Wiens, Kirsten E, Lindstedt, Paulina A, Blacker, Brigette F, Johnson, Kimberly B, Baumann, Mathew M, Schaeffer, Lauren E, Abbastabar, Hedayat, Sr, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Abegaz, Kedir Hussein, Abejie, Ayenew Negesse, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abualhasan, Ahmed, Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adabi, Maryam, Adamu, Abdu A, Adebayo, Oladimeji M, Adedoyin, Rufus Adesoji, Sr, Adekanmbi, Victor, Adetokunboh, Olatunji O, Sr, Adhena, Beyene Meressa, Afarideh, Mohsen, Ahmad, Sohail, Ahmadi, Keivan, Ahmed, Anwar E, Ahmed, Muktar Beshir, Ahmed, Rushdia, Akalu, Temesgen Yihunie, Alahdab, Fares, Al-Aly, Ziyad, Alam, Noore, Sr, Alam, Samiah, Alamene, Genet Melak, Alanzi, Turki M, Alcalde-Rabanal, Jacqueline Elizabeth, Ali, Beriwan Abdulqadir, Alijanzadeh, Mehran, Alipour, Vahid, Aljunid, Syed Mohamed, Almasi, Ali, Sr, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J, Amini, Saeed, Sr, Amit, Arianna Maever L, Sr, Andrei, Catalina Liliana, Sr, Anjomshoa, Mina, Anoushiravani, Amir, Sr, Ansari, Fereshteh, Antonio, Carl Abelardo T, Antony, Benny, Antriyandarti, Ernoiz, Arabloo, Jalal, Aref, Hany Mohamed Amin, Sr, Aremu, Olatunde, Armoon, Bahram, Arora, Amit, Sr, Aryal, Krishna K, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Atalay, Hagos Tasew, Athari, Seyyed Shamsadin, Sr, Athari, Seyyede Masoume, Atre, Sachin R, Ausloos, Marcel, Awoke, Nefsu, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Sr, Aynalem IV, Yared Asmare, Azari, Samad, Azzopardi, Peter S, Babaee, Ebrahim, Babalola, Tesleem Kayode, Badawi, Alaa, Sr, Bairwa, Mohan, Bakkannavar, Shankar M, Balakrishnan, Senthilkumar, Bali, Ayele Geleto, Banach, Maciej, Sr, Banoub, Joseph Adel Mattar, Sr, Barac, Aleksandra, Bärnighausen, Till Winfried, Basaleem, Huda, Basu, Sanjay, Bay, Vo Dinh, Bayati, Mohsen, Baye, Estifanos, Bedi, Neeraj, Beheshti, Mahya Mahya Beheshti, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Bayu Begashaw, Belayneh, Yaschilal Muche, Bell, Michellr L, Sr, Bennett, Derrick A, Sr, Berbada, Dessalegn Ajema, Bernstein, Robert S, Bhat, Anusha Ganapati, Sr, Bhattacharyya, Krittika, Sr, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Boris, Birihane IV, Binyam Minuye, Biswas, Raaj Kishore, Bohlouli, Somayeh, Bojia I, Hunduma Amensisa Amensisa, Boufous, Soufiane, Brady, Oliver J, Bragazzi, Nicola Luigi, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B, Burugina Nagaraja, Sharath, Sr, Busse, Reinhard, Sr, Butt, Zahid A, Cámera, Luis LA Alberto, Sr, Campos-Nonato, Ismael R, Sr, Cano, Jorge, Car, Josip, Cárdenas, Rosario, Carvalho, Felix, Sr, Castañeda-Orjuela, Carlos A, Sr, Castro, Franz, Chanie, Wagaye Fentahun, Sr, Chatterjee, Pranab, Chattu, Vijay Kumar, Chichiabellu, Tesfaye Yitna Yitna, Jr, Chin, Ken Lee, Sr, Christopher, Devasahayam J, Chu, Dinh-Toi, Cormier, Natalie Maria, Costa, Vera Marisa, Culquichicon, Carlos, Daba, Matiwos Soboka, Damiani, Giovanni, Sr, Dandona, Lalit, Dandona, Rakhi, Dang, Anh Kim, Darwesh, Aso Mohammad, Darwish, Amira Hamed, Daryani, Ahmad, Sr, Das, Jai K, Das Gupta, Rajat, Dash, Aditya Prasad, Davey, Gail, Dávila-Cervantes, Claudio Alberto, Davis, Adrian C, Sr, Davitoiu, Dragos Virgil, De la Hoz, Fernando Pio, Demis, Asmamaw Bizuneh, Demissie, Dereje Bayissa, Demissie, Getu Debalkie, Demoz, Gebre Teklemariam, Sr, Denova-Gutiérrez, Edgar, Sr, Deribe, Kebede, Sr, Desalew, Assefa, Deshpande, Aniruddha, Dharmaratne, Samath Dhamminda, Dhillon, Preeti, Dhimal, Meghnath, Dhungana, Govinda Prasad, Diaz, Daniel, Sr, Dipeolu, Isaac Oluwafemi, Djalalinia, Shirin, Doyle, Kerrie E, Dubljanin, Eleonora, Duko, Bereket, Duraes, Andre Rodrigues, Ebrahimi Kalan, Mohammad, Edinur, Hisham Atan, Sr, Effiong, Andem, Sr, Eftekhari, Aziz, El Nahas, Nevine, El Sayed, Iman, El Sayed Zaki, Maysaa, El Tantawi, Maha, Elema I, Teshome Bekele, Elhabashy, Hala Rashad, Sr, El-Jaafary, Shaimaa I, Elkout, Hajer, Elsharkawy, Aisha, Elyazar, Iqbal RF, Endalamaw, Aklilu, Endalew, Daniel Adane, Sr, Eskandarieh, Sharareh, Esteghamati, Alireza, Esteghamati, Sadaf, Sr, Etemadi, Arash, Ezekannagha, Oluchi, Fareed, Mohammad, Faridnia, Roghiyeh, Farzadfar, Farshad, Fazlzadeh, Mehdi, Feigin, Valery L, Sr, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Filip, Irina, Fischer, Florian, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Sr, Foroutan, Masoud, Franklin, Richard Charles, Fukumoto, Takeshi, Gad, Mohamed M, Gayesa, Reta Tsegaye, Gebre, Teshome, Sr, Gebremedhin, Ketema Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Sr, Gesesew, Hailay Abrha, Gezae, Kebede Embaye, Ghadiri, Keyghobad, Sr, Ghashghaee, Ahmad, Ghimire, Pramesh Raj, Sr, Gill, Paramjit Singh, Sr, Gill, Tiffany K, Ginindza, Themba G G, Gomes, Nelson G M, Gopalani, Sameer Vali, Goulart, Alessandra C, Goulart, Bárbara Niegia Garcia, Grada, Ayman, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Sr, Guido, Davide, Guimarães, Rafael Alves, Guo, Yuming, Sr, Gupta, Rajeev, Hafezi-Nejad, Nima, Haile, Dessalegn H, Sr, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R, Hamidi, Samer, Handiso, Demelash Woldeyohannes, Haririan, Hamidreza, Sr, Hariyani, Ninuk, Hasaballah, Ahmed I, Hasan, Md Mehedi, Hasanpoor, Edris, Hasanzadeh, Amir, Hassankhani, Hadi, Hassen, Hamid Yimam, Hegazy, Mohamed I, Heibati, Behzad, Heidari, Behnam, Hendrie, Delia, Sr, Henry, Nathaniel J, Herteliu, Claudiu, Heydarpour, Fatemeh, Hidru I, Hagos Degefa de, Hird, Thomas R, Hoang, Chi Linh, Homaie Rad, Enayatollah, Hoogar, Praveen, Hoseini, Mohammad, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Househ, Mowafa, Hsairi, Mohamed, Sr, Hu, Guoqing, Hussen, Mohammedaman Mama, Ibitoye, Segun Emmanuel, Igumbor, Ehimario U, Sr, Ilesanmi, Olayinka Stephen, Ilic, Milena D, Imani-Nasab, Mohammad Hasan, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Islam, Sheikh Mohammed Shariful, Iwu, Chinwe Juliana, Izadi, Neda, Sr, Jaca, Anelisa, Jahanmehr, Nader, Jakovljevic, Mihajlo, Jalali, Amir, Jayatilleke, Achala Upendra, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S, Sr, Jonas, Jost B, Jozwiak, Jacek Jerzy, Kabir, Ali, Kabir, Zubair, Sr, Kahsay, Amaha, Kalani, Hamed, Kanchan, Tanuj, Karami Matin, Behzad, Karch, André, Karim, Mohd Anisul, Karimi-Sari, Hamidreza, Karki, Surendra, Kasaeian, Amir, Kasahun, Gebremicheal Gebreslassie, Kasahun, Yawukal chane, Kasaye, Habtamu Kebebe, Kassa, Gebrehiwot G, Kassa, Getachew Mullu, Kayode, Gbenga A, Kazemi Karyani, Ali, Kebede, Mihiretu M, Keiyoro, Peter Njenga, Kelbore, Abraham Getachew, Sr, Kengne, Andre Pascal, Sr, Ketema, Daniel Bekele, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalid, Nauman, Khalilov, Rovshan, Khan, Ejaz Ahmad, Sr, Khan, Junaid, Khan I, Md Nuruzzaman, Khan, Muhammad Shahzeb, Khatab, Khaled, Sr, Khater, Amir M, Khater, Mona M, Khayamzadeh, Maryam, Khazaei, Mohammad, Khazaei, Salman, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kiadaliri, Ali, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Kissoon, Niranjan, Sr, KMShivakumar, Shivakumar KM Marulasiddaiah M, Sr, Kochhar, Sonali, Kolola, Tufa, Sr, Komaki, Hamidreza, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kraemer, Moritz U G, Krishan, Kewal, Kugbey, Nuworza, Kumar, G Anil, Kumar, Manasi, Sr, Kumar, Pushpendra, Kumar, Vivek, Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lad, Sheetal D, Lal, Dharmesh Kumar, Lam, Felix, Lami, Faris Hasan, Sr, Lamichhane, Prabhat, Lansingh, Van Charles, Lasrado, Savita, Laxmaiah, Avula, Lee, Paul H, Sr, LeGrand, Kate E, Leili, Mostafa, Lenjebo, Tsegaye Lolaso, Leshargie, Cheru Tesema, Sr, Levine, Aubrey J, Li, Shanshan, Sr, Linn, Shai, Liu, Shiwei, Liu, Simin, Lodha, Rakesh, Longbottom, Joshua, Lopez, Jaifred Christian F, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Mahadeshwara Prasad, D R, Mahasha, Phetole Walter, Sr, Mahotra, Narayan B, Majeed, Azeem, Malekzadeh, Reza, Sr, Malta, Deborah Carvalho, Mamun, Abdullah A, Sr, Manafi, Navid, Sr, Manda, Ana Laura, Manohar, Narendar Dawani Dawanu, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Maravilla, Joemer C, Martinez, Gabriel, Sr, Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Massenburg, Benjamin Ballard, Mathur, Manu Raj, Mayala, Benjamin K, Mazidi, Mohsen, McAlinden, Colm, Meharie, Birhanu Geta, Mehndiratta, Man Mohan, Sr, Mehta, Kala M, Mekonnen, Tefera C Chane, Meles, Gebrekiros Gebremichael, Memiah, Peter T N, Memish, Ziad A, Sr, Mendoza, Walter, Menezes, Ritesh G, Mereta, Seid Tiku, Meretoja, Tuomo J, Sr, Mestrovic, Tomislav, Miazgowski, Bartosz, Mihretie, Kebadnew Mulatu, Sr, Miller, Ted R, Mini, GK, Mirrakhimov, Erkin M, Moazen, Babak, Mohajer, Bahram, Mohamadi-Bolbanabad, Amjad, Mohammad, Dara K, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadibakhsh, Roghayeh, Mohammadifard, Noushin, Mohammed, Jemal Abdu, Sr, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Molokhia, Mariam, Monasta, Lorenzo, Moodley, Yoshan, Sr, Moore, Catrin E, Sr, Moradi, Ghobad, Moradi, Masoud, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moraga, Paula, Morales, Linda, Moreno Velásquez, Ilais, Mosapour, Abbas, Mouodi, Simin, Mousavi, Seyyed Meysam, Mozaffor I, Miliva, Muchie, Kindie Fentahun, Sr, Mulaw, Getahun Fentaw, Sr, Munro, Sandra B, Muriithi, Moses K, Murray, Christopher J L, Murthy, GVS, Musa, Kamarul Imran, Mustafa, Ghulam, Sr, Muthupandian, Saravanan, Sr, Nabhan, Ashraf F, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Naidoo, Kovin S, Naik, Gurudatta, Najafi, Farid, Nangia, Vinay, Sr, Nansseu, Jobert Richie, Nascimento, Bruno Ramos, Sr, Nazari, Javad, Ndwandwe, Duduzile Edith, Sr, Negoi, Ionut, Sr, Netsere, Henok Biresaw Netsere, Sr, Ngunjiri, Josephine W, Sr, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Nigatu, Dabere, Nigatu, Solomon Gedlu, Ningrum, Dina Nur Anggraini, Nnaji, Chukwudi A, Nojomi, Marzieh, Nong, Vuong Minh, Norheim, Ole F, Sr, Noubiap, Jean Jacques, Nouraei Motlagh, Soraya, Oancea, Bogdan, Ogah, Okechukwu Samuel, Ogbo, Felix Akpojene, Oh, In-Hwan, Olagunju, Andrew T, Olagunju, Tinuke O, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Onwujekwe, Obinna E, Sr, Oren, Eyal, Ortega-Altamirano, Doris V V, Sr, Osarenotor, Osayomwanbo, Osei, Frank B, Sr, Owolabi, Mayowa O, P A, Mahesh, Sr, Padubidri, Jagadish Rao, Pakhale, Smita, Patel, Sangram Kishor, Paternina-Caicedo, Angel J, Sr, Pathak, Ashish, Sr, Patton, George C, Paudel, Deepak, Sr, Paulos, Kebreab, Sr, Pepito, Veincent Christian Filipino, Pereira, Alexandre, Perico, Norberto, Pervaiz, Aslam, Pescarini, Julia Moreira, Piroozi, Bakhtiar, Pirsaheb, Meghdad, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Sr, Pourshams, Akram, Poustchi, Hossein, Prada, Sergio I, Sr, Prasad, Narayan, Preotescu, Liliana, Quintana, Hedley, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi-Movaghar, Afarin, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rahman, SHAFIUR, Rajati, Fatemeh, Sr, Rana, Saleem Muhammad, Sr, Ranabhat, Chhabi Lal, Rasella, Davide, Rawaf, David Laith, Rawaf, Salman, Sr, Rawal, Lal, Rawasia, Wasiq Faraz, Renjith, Vishnu, Renzaho, Andre M N, Sr, Resnikoff, Serge, Sr, Reta, Melese Abate, Rezaei, Negar, Rezai, Mohammad sadegh, Riahi, Seyed Mohammad, Ribeiro, Ana Isabel, Rickard, Jennifer, Sr, Rios-Blancas, Maria, Roever, Leonardo, Ronfani, Luca, Roro, Elias Merdassa, Sr, Ross, Jennifer M, Rubagotti, Enrico, Rubino, Salvatore, Saad, Anas M, Sabde, Yogesh Damodar, Sabour, Siamak, Sadeghi, Ehsan, Sr, Safari, Yahya, Safari-Faramani, Roya, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S Mohammad, Salahshoor, Mohammad Reza, Salam, Nasir, Sr, Salamati, Payman, Salem, Hosni, Salem I, Marwa R Rashad, Salimi, Yahya, Salimzadeh, Hamideh, Samy, Abdallah M, Sanabria, Juan, Sr, Santric-Milicevic, Milena M, Sao Jose, Bruno Piassi, Saraswathy, Sivan Yegnanarayana Iyer, Sarkar, Kaushik, Sr, Sarker, Abdur Razzaque, Sarrafzadegan I, Nizal, Sartorius, Benn, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sawhney, Monika, Saxena, Sonia, Sr, Schwebel, David C, Sr, Senbeta IV, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serván-Mori, Edson, Sr, Shabaninejad, Hosein, Shafieesabet, Azadeh, Sr, Shaikh, Masood Ali, Shalash, Ali S, Sr, Shallo, Seifadin Ahmed, Shams-Beyranvand, Mehran, Shamsi, MohammadBagher, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomars, Sharifi, Hamid, Shehata, Hatem Samir, Sr, Sheikh, Aziz, Shetty, B Suresh Kumar, Sr, Shibuya, Kenji, Sr, Shiferaw, Wondimeneh Shibabaw, Sr, Shifti, Desalegn Markos, Shigematsu, Mika, Shin, Jae Il, Shiri, Rahman, Sr, Shirkoohi, Reza, Siabani, Soraya, Siddiqi, Tariq Jamal, Silva, Diego Augusto Santos, Singh, Ambrish, Singh, Jasvinder A, Singh, Narinder Pal, Singh, Virendra, Sisay, Malede Mequanent, Skiadaresi, Eirini, Sobhiyeh, Mohammad Reza, Sr, Sokhan, Anton, Soltani, Shahin, Somayaji, Ranjani, Soofi, Moslem, Sorrie, Muluken Bekele, Sr, Soyiri, Ireneous N, Sreeramareddy, Chandrashekhar T, Sudaryanto, Agus, Sufiyan, Mu'awiyyah Babale, Sr, Suleria, Hafiz Ansar Rasul, Sultana, Marufa, Sunguya, Bruno Fokas, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Tadesse, Degena Bahrey, Jr, Tarigan, Ingan Ukur, Tasew, Aberash Abay, Tefera, Yonatal Mesfin, Sr, Tekle, Merhawi Gebremedhin, Temsah, Mohamad-Hani, Tesfay I, Berhe Etsay, Tesfay, Fisaha Haile Haile, Tessema, Belay, Tessema, Zemenu Tadesse, Thankappan, Kavumpurathu Raman, Thomas, Nihal, Toma, Alemayehu Toma, Sr, Topor-Madry, Roman, Tovani-Palone, Marcos Roberto Roberto, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Ullah, Irfan, Unnikrishnan, Bhaskaran, Usman, Muhammad Shariq, Sr, Uzochukwu, Benjamin S Chudi, Sr, Valdez, Pascual R, Varughese, Santosh, Sr, Violante, Francesco S, Sr, Vollmer, Sebastian, Sr, W/hawariat, Feleke Gebremeskel, Sr, Waheed, Yasir, Wallin, Mitchell Taylor, Wang, Yafeng, Wang, Yuan-Pang, Weaver, Marcia, Weji, Bedilu Girma, Weldesamuel, Girmay Teklay, Welgan, Catherine A, Werdecker, Andrea, Westerman, Ronny, Sr, Wiangkham, Taweewat, Wiysonge, Charles Shey, Sr, Wolde, Haileab Fekadu, Sr, Wondafrash, Dawit Zewdu, Wonde, Tewodros Eshete, Sr, Worku, Getasew Taddesse, Sr, Wu, Ai-Min, Xu, Gelin, Yadollahpour, Ali, Yahyazadeh Jabbari, Seyed Hossein, Yamada, Tomohide, Sr, Yatsuya, Hiroshi, Yeshaneh, Alex, Yilgwan, Christopher Sabo, Yilma, Mekdes Tigistu, Yip, Paul, Sr, Yisma, Engida, Yonemoto, Naohiro, Sr, Yoon, Seok-Jun, Younis, Mustafa Z, Yousefifard, Mahmoud, Yousof, Hebat-Allah Salah A, Yu, Chuanhua, Yusefzadeh, Hasan, Zadey, Siddhesh, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zandian, Hamed, Zepro, Nejimu Biza, Zerfu, Taddese Alemu, Zhang, Yunquan, Zhao, Xiu-Ju George, Ziapour, Arash, Zodpey, Sanjay, Sr, Zuniga, Yves Miel H, Hay, Simon I, and Reiner, Robert C, Jr

Published
2020
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165. OGT prevents DNA demethylation and suppresses the expression of transposable elements in heterochromatin by restraining TET activity genome-wide

Author

Sepulveda, Hugo, primary, Li, Xiang, additional, Yue, Xiaojing, additional, Carlos Angel, J., additional, Arteaga-Vazquez, Leo J., additional, Brown, Caitlin, additional, Brunelli, Melina, additional, Jansz, Natasha, additional, Puddu, Fabio, additional, Scotcher, Jamie, additional, Creed, Páidí, additional, Kennedy, Patrick, additional, Manriquez, Cindy, additional, Myers, Samuel A, additional, Crawford, Robert, additional, Faulkner, Geoffrey J., additional, and Rao, Anjana, additional

Published
2024
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170. Inhibition of Enzymatic Acetylation-Mediated Resistance to Plazomicin by Silver Ions

Author

David Ngo, Angel J. Magaña, Tung Tran, Jan Sklenicka, Kimberly Phan, Brian Eykholt, Verónica Jimenez, María S. Ramirez, and Marcelo E. Tolmasky

Subjects
AAC(2′)-Ia, aminoglycoside 2′-N-acetyltransferase type Ia, aminoglycoside, multidrug resistance, metal ions, plazomicin, Medicine, Pharmacy and materia medica, RS1-441
Abstract

Plazomicin is a recent U.S. Food and Drug Administration (FDA)-approved semisynthetic aminoglycoside. Its structure consists of a sisomicin scaffold modified by adding a 2(S)-hydroxy aminobutyryl group at the N1 position and a hydroxyethyl substituent at the 6′ position. These substitutions produced a molecule refractory to most aminoglycoside-modifying enzymes. The main enzyme within this group that recognizes plazomicin as substrate is the aminoglycoside 2′-N-acetyltransferase type Ia [AAC(2′)-Ia], which reduces the antibiotic’s potency. Designing formulations that combine an antimicrobial with an inhibitor of resistance is a recognized strategy to extend the useful life of existing antibiotics. We have recently found that several metal ions inhibit the enzymatic inactivation of numerous aminoglycosides mediated by the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib]. In particular, Ag+, which also enhances the effect of aminoglycosides by other mechanisms, is very effective in interfering with AAC(6′)-Ib-mediated resistance to amikacin. Here we report that silver acetate is a potent inhibitor of AAC(2′)-Ia-mediated acetylation of plazomicin in vitro, and it reduces resistance levels of Escherichia coli carrying aac(2′)-Ia. The resistance reversion assays produced equivalent results when the structural gene was expressed under the control of the natural or the blaTEM-1 promoters. The antibiotic effect of plazomicin in combination with silver was bactericidal, and the mix did not show significant toxicity to human embryonic kidney 293 (HEK293) cells.

Published
2023
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171. Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies

Author

James Paul Mason, Alexandra Werth, Colin G. West, Allison Youngblood, Donald L. Woodraska, Courtney L. Peck, Arvind J. Aradhya, Yijian Cai, David Chaparro, James W. Erikson, Koushik Ganesan, T. R. Geerdts, Thi D Hoang, Thomas M. Horning, Yan Jin, Haixin Liu, Noah Lordi, Zheng Luo, Thanmay S. Menon, Josephine C. Meyer, Emma E Nelson, Kristin A. Oliver, Jorge L Ramirez Ortiz, Andrew Osborne, Alyx Patterson, Nick Pellatz, John Pitten, Nanako Shitara, Daniel Steckhahn, Aseem Visal, Hongda Wang, Chaoran Wang, Evan Wickenden, John Wilson, Mengyu Wu, Nikolay Yegovtsev, Ingrid H Zimmermann, James Holland Aaron, Jumana T. Abdullah, Jonathan M. Abrams, Riley Abrashoff, Andres B. Acevedo, Iker Acha, Daniela M. Meza Acosta, Megan M. Adam, Dante Q. Adams, Kalvyn N Adams, Elena R Adams, Zainab A. Akbar, Ushmi H. Akruwala, Adel Al-Ghazwi, Batool H. Alabbas, Areej A. Alawadhi, Yazeed A. Alharbi, Mohammed S. Alahmed, Mohammed A. Albakr, Yusef J. Albalushi, Jonathan Albaum, Ahmed Aldhamen, Nolan Ales, Mohammad Alesmail, Abdulelah Alhabeeb, Dania Alhamli, Isehaq Alhuseini, Suhail Alkaabi, Tameem Alkhezzi, Mohamed Alkubaisi, Nasser Allanqawi, Martin Allsbrook, Yousef A. Almohsen, Justin Thomas Almquist, Teeb Alnaji, Yousef A Alnasrallah, Nicholas Alonzi, Meshal Alosaimi, Emeen Alqabani, Mohammad Alrubaie, Reema A. Alsinan, Ava L. Altenbern, Abdullah Altokhais, Saleh A. Alyami, Federico Ameijenda, Hamzi Amer, Meggan Amos, Hunter J. Anderson, Carter Andrew, Jesse C Andringa, Abigail Angwin, Gabreece Van Anne, Andrew Aramians, Camila Villamil Arango, Jack. W. Archibald, Brian A. Arias-Robles, Maryam Aryan, Kevin Ash, Justin Astalos, N. S. Atchley-Rivers, Dakota N. Augenstein, Bryce W. Austin, Abhinav Avula, Matthew C. Aycock, Abdulrahman A. Baflah, Sahana Balaji, Brian Balajonda, Leo M Balcer, James O. Baldwin, David J Banda, Titus Bard, Abby Barmore, Grant M. Barnes, Logan D. W. Barnhart, Kevin M. Barone, Jessica L. Bartman, Claire Bassel, Catalina S Bastias, Batchimeg Bat-Ulzii, Jasleen Batra, Lexi Battist, Joshua Bay, Simone Beach, Sara Beard, Quinn I Beato, Ryan Beattie, Thomas Beatty, Tristan De La Beaujardiere, Jacob N. Beauprez, M. G. Beck, Lily Beck, Simone E. Becker, Braden Behr, Timothy A. Behrer, Joshua Beijer, Brennan J. Belei, Annelene L. Belknap, Aislyn Bell, Caden Bence, Evan Benke, Naomi Berhanu, Zachary D. Berriman-Rozen, Chrisanna Bertuccio, Owen A. Berv, Blaine B. Biediger, Samuel J Biehle, Brennen Billig, Jacob Billingsley, Jayce A. Billman, Connor J. Biron, Gabrielle E. Bisacca, Cassidy A. Blake, Guillermo Blandon, Olivia Blevins, Ethan Blouin, Michal Bodzianowski, Taylor A. Boeyink, Matthew Bondar, Lauren Bone, Alberto Espinosa De Los Monteros Bonilla, William T Borelli, Luke R. Borgerding, Troy Bowen, Christine Boyer, Aidan Boyer, Aidan P. Boyle, Tom Boyne, Donovan Branch, Ariana E. Brecl, David J. Brennan, Alexander J Brimhall, Jennifer L. Brockman, Sarah Brookins, Gabriel T. Brown, Cameron L. Brown, Ryan Brown, Jordi Brownlow, Grant Brumage-Heller, Preston J. Brumley, Samuel Bryan, A. Brzostowicz, Maryam Buhamad, Gigi Bullard-Connor, J. R. Ramirez Bunsow, Annemarie C. Burns, John J. Burritt, Nicholas David Burton, Taylor Burton, Celeste Busch, Dylan R. Butler, B. W. Buxton, Malena C. Toups, Carter C. Cabbage, Breonna Cage, Jackson R. Cahn, Andrew J Campbell, Braden P. Canales, Alejandro R. Cancio, Luke Carey, Emma L. Carillion, Michael Andrew Carpender, Emily Carpenter, Shivank Chadda, Paige Chambers, Jasey Chanders, Olivia M. Chandler, Ethan C. Chang, Mitchell G. Chapman, Logan T. Chapman, S. Chavali, Luis Chavez, Kevin Chen, Lily Chen, Sam Chen, Judy Chen, Jenisha Chhetri, Bradyn Chiles, Kayla M. Chizmar, Katherine E Christiansen, Nicholas A. Cisne, Alexis Cisneros, David B. Clark, Evelyn Clarke, Peter C Clarkson, Alexis R. Clausi, Brooke Cochran, Ryan W. Coe, Aislinn Coleman-Plante, Jake R. Colleran, Zachary Colleran, Curran Collier, Nathaniel A. Collins, Sarah Collins, Jack C. Collins, Michael Colozzi, Aurora Colter, Rebecca A. Cone, Thomas C. Conroy, Reese Conti, Charles J. Contizano, Destiny J. Cool, Nicholas M. Cooper, Jessica S Corbitt, Jonas Courtney, Olivia Courtney, Corben L. Cox, Wilmsen B. Craig, Joshua B. Creany, Anastasia Crews, K. A. Crocker, A. J. Croteau, Christian J. Crow, Zoe Cruse, Avril Cruz, Tyler L. Curnow, Hayden Current, Riley T. Curry, Libby Cutler, Aidan St. Cyr, Frederick M. Dabberdt, Johnston Daboub, Olivia Damgaard, Swagatam Das, Emma A. B. Davis, Elyse Debarros, Sean Deel, Megan E. Delasantos, Tianyue Deng, Zachary Derwin, Om Desai, Kai Dewey, John S. Dias, Kenzie A. Dice, R. Dick, Cyrus A. Dicken, Henry Dietrick, Alexis M. Dinser, Alyssa M. Dixon, Thomas J. Dixon, Helen C. Do, Chris H Doan, Connor Doane, Joshua Dodrill, Timothy Doermer, Lizbeth Montoya Dominguez, J. Dominguez, Emerson N. Domke, Caroline R. Doran, Jackson A. Dorr, Philip Dorricott, Danielle C. Dresdner, Michael Driscoll, Kailer H. Driscoll, Sheridan J. Duncan, Christian Dunlap, Gabrielle M. Dunn, Tien Q. Duong, Tomi Oshima Dupeyron, Peter Dvorak, Andrew East, Andrew N. East, Bree Edwards, Lauren Ehrlich, Sara I. Elbashir, Rasce Engelhardt, Jacob Engelstad, Colin England, Andrew Enrich, Abbey Erickson, Benjamin Erickson, Nathan Evans, Calvin A Ewing, Elizabeth A. Eyeson, Ian Faber, Avery M. Fails, John T Fauntleroy, Kevin Fell, Zitian Feng, Logan D. Fenwick, Nikita Feoktistov, Ryann Fife, John Alfred D. Figueirinhas, Jean-Paul Fisch, Emmalee Fischer, Jules Fischer-White, Aidan F. Fitton, Alexander Fix, Lydia Flackett, Fernando Flores, Aidan Floyd, Leonardo Del Foco, Adeduni Folarin, Aidan E. Forbes, Elise Fortino, Benjamin L. Fougere, Alexandra A. Fowler, Margaret Fox, James M. French, Katherine V. French, Florian G. Frick, Calvin R. Fuchs, Bethany E. S. Fuhrman, Sebastian Furney, Moutamen Gabir, Gabriela Galarraga, Skylar Gale, Keala C. Gapin, A. J. Garscadden, Rachel Gasser, Lily Gayou, Emily E. Gearhart, Jane Geisman, Julianne R. Geneser, Sl Genne, Julia G Gentile, Eleanor Gentry, Jacob D. George, Nathaniel James Georgiades, Phillip Gerhardstein, Clint Gersabeck, Bandar Abu Ghaith, Dorsa Ghiassi, B. C. Giebner, Dalton Gilmartin, Connor B. Gilpatrick, Michael Gjini, Olivia Golden, Nathan T. Golding, C. A. Goldsberry, Angel R. Gomez, Angel A. Gomez, Sean Gopalakrishnan, Mariam Gopalani, Nicholas Gotlib, Alaina S. Graham, Michael J Gray, Alannah H. Gregory, Joshua A. Gregory, Kristyn Grell, Justus Griego, Nicholas F. Griffin, Kyle J. Griffin, Matt Guerrero, Nicole Gunderson, Mutian Guo, E. R. Gustavsson, Grace K. Hach, L. N. Haile, Jessica Haines, Jack J. Mc Hale, Ryder Buchanan Hales, Mark S. Haley, Jacqueline L. Hall, Sean R. Hamilton, Soonhee Han, Tyler Hand, Luke C. Hanley, Connor M Hansen, Joshua A. Hansen, Jonathan Hansson, Tony Yunfei Hao, Nicholas Haratsaris, Isabelle Hardie, Dillon F. Hardwick, Cameron T. Hares, Logan Swous Harris, Coyle M. Harris, Omer Hart, Kyle Hashiro, Elsie Hattendorf, Calder Haubrich, Elijah Hawat, Griffin A. Hayrynen, Danielle A. Heintz, Tim Hellweg, Angel Hernandez, Emanuel Herrera, Robert N. Herrington, Tim Herwig, Troy M. Hesse, Quinn Hiatt, Lea Pearl Hibbard, Imari R. Hicks, Andrew J. Hicks, Nigel Highhouse, Annalise K. Hildebrand, Paula Hill, Hallie Hill, Evan Hintsa, Anna E. Hirschmann, Travis Hitt, Ella Ho, Isabelle J. Hoff, Alex Hoffman, Blake A. Hogen, Linda Horne, Timothy J Houck, Noah H. Howell, E. M. Hrudka, J. Hu, Jianyang Huang, Chenqi Huang, Shancheng Huang, Zachary A. Hudson, Nathan C. Hudson, Tyler J. Huebsch, Owen Hull, Samuel C Hunter, Troy Husted, Abigail P. Hutabarat, Leslie Huynh, Antonio E. Samour Ii, Yolande Idoine, Julia A. Ingram, Taro Iovan, Samuel A. Isert, Antonio Salcido-Alcontar Jr, Thomas Jacobsen, Alan A Jaimes, Connor Jameson, J. R. Jarriel, Sam Jarvis, Josh Jenkins, Alexander V. Jensen, Jacob Jeong, Luke A. Jeseritz, Trevor Jesse, Soo Yeun Ji, Yufan Jiang, Owen Johnson, Matthew Johnson, Sawyer Johnson, Julia Johnston, Braedon Y. Johnston, Olivia M. Jones, M. R. Jones, Tara Jourabchi, Tony A. House Jr., Parker Juels, Sabrina J. H. T. Kainz, Emily Kaiser, Nicolas Ian Kallemeyn, Madison H. Kalmus, Etash Kalra, Margaret Kamenetskiy, Jeerakit Kanokthippayakun, Shaun D. Kapla, Brennan J. Karsh, Caden J. Keating, Morgan A. Kelley, Michael P. Kelley, Nicholas Kelly, James Kelly, Teagan Kelly, Christopher M Kelly, Kellen Kennedy, Cayla J. Kennedy, Forrest Kennedy, Abigail Kennedy, Liana Kerr-Layton, Marilyn Ketterer, Ibraheem A. Khan, Usman Khan, Sapriya Khanal, Jack L. Kiechlin, Dominic Killian, Kevin Kim, Brian T. Kim, Matthew M. Kim, Jake Kim, Aspen Kimlicko, Isabel M Kipp, Hunter B. Kirkpatrick, Natalie Kissner, Emily R. Kite, Olivia R. Kleinhaus, Philip Whiting Knott, Will Koch, Greta Koenig, Emily Koke, Thomas Kokes, Yash S. Kothamdi, Zack Krajnak, Zoe M. Kresek, Dylan Kriegman, Jake E. Kritzberg, Davis J. Krueger, Bartlomiej Kubiak, Kirsten Kuehl, Chrisanne Kuester, Nicolas A. Kuiper, Aman Priyadarshi Kumar, Connor Kuybus, Daniel Kwiatkowski, Quintin Y. Lafemina, Kevin Lacjak, Kyle Lahmers, Antonia Lam, Kalin Landrey, Maxwell B. Lantz, Zachary Larter, Benjamin P. Lau, Megan Lauzon, Rian Lawlor, Tyler Learned, E. C. Lee, Junwon Lee, Adrianna J. Lee, Justin Lee, Alexis Ying-Shan Lee, Christian J Lee, Nathaniel F. Lee, Linzhi Leiker, Dylan Lengerich, Cecilia Leoni, Adrienne R. Lezak, David Y. Li, Isaac Li, Ryan Z. Liao, Bridget Linders, Morgan I Linger, Katherine B. Linnane, Sam Lippincott, Barrett Lister, Shelby D Litton, Nianzi Liu, Steven Y. Liu, Timothy W. Logan, Nathan Londres, Mia C. Lonergan, Emily Lookhoff, N. E. Loomis, Christian Lopez, Justin Loring, Jeffrey Lucca, Dax Lukianow, Nathan M. Cheang, William Macdonald, Claire A. Madonna, Kasey O. Madsen, Tiffany E. Maksimuk, Macguire Mallory, Ryan A. Malone, Blake Maly, Xander R. Manzanares, Aimee S. Maravi, Serafima M. Marcus, Nasreen Marikar, Josie A. Marquez, Mathew J. Marquez, Lauren Marsh, Toni Marsh, Logan S. Martin, Alexa M. Martinez, Jose R. Martinez, Hazelia K. Martinez, Cara Martyr, Mirna Masri, Giorgio Matessi, Adam Izz Khan Mohd Reduan Mathavan, Randi M. Mathieson, Kabir P. Mathur, Graham Mauer, Victoria A. Mayer, Liam Mazzotta, Glen S. Mccammon, Rowan Mcconvey, Tyler Mccormick, Andrew Mccoy, Kelleen Mcentee, Meaghan V. Mcgarvey, Riley M. Mcgill, James K. Mcintyre, Finbar K. Mckemey, Zane Mcmorris, Jesse J. Mcmullan, Ella Mcquaid, Caden Mcvey, Kyle Mccurry, Mateo M. Medellin, Melissa Medialdea, Amar Mehidic, Stella Meillon, Jonah B. Meiselman-Ashen, Sarah Mellett, Dominic Menassa, Citlali Mendez, Patricia Mendoza-Anselmi, Riley Menke, Sarah Mesgina, William J. Mewhirter, Ethan Meyer, Aya M. Miften, Ethan J. Miles, Andrew Miller, Joshua B. Miller, Emily B. Millican, Sarah J. Millican, Dylan P. Mills, Josh Minimo, Jay H. Misener, Alexander J. Mitchell, Alexander Z. Mizzi, Luis Molina-Saenz, Tyler S Moll, Hayden Moll, Maximus Montano, Michael Montoya, Eli Monyek, Jacqueline Rodriguez Mora, Gavin Morales, Genaro Morales, Annalise M. Morelock, Cora Morency, Angel J. Moreno, Remy Morgan, Alexander P. Moss, Brandon A. Muckenthaler, Alexander Mueller, Owen T. Mulcahy, Aria T. Mundy, Alexis A. Muniz, Maxwell J. Murphy, Madalyn C. Murphy, Ryan C. Murphy, Tyler Murrel, Andrew J. Musgrave, Michael S. Myer, Kshmya Nandu, Elena R. Napoletano, Abdulaziz Naqi, Anoothi Narayan, Liebe Nasser, Brenna K Neeland, Molly Nehring, Maya Li Nelson, Lena P. Nguyen, Lena Nguyen, Leonardo Nguyen, Valerie A. Nguyen, Khoa D Nguyen, Kelso Norden, Cooper Norris, Dario Nuñez, Rosemary O. Nussbaum, Cian O’Sullivan, Ian O’Neill, S. H. Oakes, Anand Odbayar, Caleb Ogle, Sean Oishi-Holder, Nicholas Olguin, Nathaniel P. Olson, Jason Ong, Elena N. Opp, Dan Orbidan, Ryan Oros, Althea E. Ort, Matthew Osborn, Austin Osogwin, Grant Otto, Jessica Oudakker, Igor Overchuk, Hannah M. Padgette, Jacqueline Padilla, Mallory Palizzi, Madeleine L. Palmgren, Adler Palos, Luke J. Pan, Nathan L. Parker, Sasha R. Parker, Evan J. Parkinson, Anish Parulekar, Paige J. Pastor, Kajal Patel, Akhil Patel, Neil S. Patel, Samuel Patti, Catherine Patton, Genevieve K. Payne, Matthew P. Payne, Harrison M. Pearl, Charles B. Beck Von Peccoz, Alexander J. Pedersen, Lily M. Pelster, Munisettha E. Peou, J. S. Perez, Freddy Perez, Anneliese Pesce, Audrey J. Petersen, B. Peterson, Romeo S. L. Petric, Joshua Pettine, Ethan J. Phalen, Alexander V. Pham, Denise M. Phan, Callie C Pherigo, Lance Phillips, Justin Phillips, Krista Phommatha, Alex Pietras, Tawanchai P. Pine, Sedique Pitsuean-Meier, Andrew M. Pixley, Will Plantz, William C. Plummer, Kaitlyn E. Plutt, Audrey E. Plzak, Kyle Pohle, Hyden Polikoff, Matthew Pollard, Madelyn Polly, Trevor J. Porter, David Price, Nicholas K. Price, Gale H. Prinster, Henry Austin Propper, Josh Quarderer, Megan S. Quinn, Oliver Quinonez, Devon Quispe, Cameron Ragsdale, Anna L. Rahn, M. Rakhmonova, Anoush K Ralapanawe, Nidhi Ramachandra, Nathaniel Ramirez, Ariana C. Ramirez, Sacha Ramirez, Parker Randolph, Anurag Ranjan, Frederick C Rankin, Sarah Grace Rapaport, Nicholas O Ratajczyk, Mia G. V. Ray, Brian D. Reagan, John C. Recchia, Brooklyn J. Reddy, Joseph Reed, Charlie Reed, Justin Reeves, Eileen N. Reh, Ferin J. Von Reich, Andrea B. Reyna, Alexander Reynolds, Hope Reynolds, Matthew Rippel, Guillermo A. Rivas, Anna Linnea Rives, Amanda M. Robert, Samuel M. Robertson, Maeve Rodgers, Stewart Rojec, Andres C. Romero, Ryan Rosasco, Beth Rossman, Michael Rotter, Tyndall Rounsefell, Charlotte Rouse, Allie C. Routledge, Marc G. Roy, Zoe A. Roy, Ryan Ruger, Kendall Ruggles-Delgado, Ian C. Rule, Madigan Rumley, Brenton M. Runyon, Collin Ruprecht, Bowman Russell, Sloan Russell, Diana Ryder, David Saeb, J. Salazar, Violeta Salazar, Maxwell Saldi, Jose A. Salgado, Adam D. Salindeho, Ethan S. 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Solorio, Lincoln Solt, Caitlin Soon, Ava A Spangler, Benjamin C. Spicer, Ashish Srivastava, Emily Stamos, Peter Starbuck, Ethan K. Stark, Travis Starling, Caitlyn Staudenmier, Sheen L. Steinbarth, Christopher H. Steinsberger, Tyler Stepaniak, Ellie N. Steward, Trey Stewart, T. C. Stewart, Cooper N. Stratmeyer, Grant L. Stratton, Jordin L. Stribling, S. A Sulaiman, Brandon J Sullivan, M. E. Sundell, Sohan N. Sur, Rohan Suri, Jason R. Swartz, Joshua D. Sweeney, Konner Syed, Emi Szabo, Philip Szeremeta, Michael-Tan D. Ta, Nolan C. Tanguma, Kyle Taulman, Nicole Taylor, Eleanor Taylor, Liam C. Taylor, K. E. Tayman, Yesica Tellez, Richard Terrile, Corey D Tesdahl, Quinn N. Thielmann, Gerig Thoman, Daniel Thomas, Jeffrey J. Thomas, William N. Thompson, Noah R. Thornally, Darien P. Tobin, Kelly Ton, Nathaniel J. Toon, Kevin Tran, Bryn Tran, Maedee Trank-Greene, Emily D. Trautwein, Robert B. Traxler, Judah Tressler, Tyson R. Trofino, Thomas Troisi, Benjamin L. Trunko, Joshua K. Truong, Julia Tucker, Thomas D Umbricht, C. H. Uphoff, Zachary T. Upthegrove, Shreenija Vadayar, Whitney Valencia, Mia M. Vallery, Eleanor Vanetten, John D. Vann, Ilian Varela, Alexandr Vassilyev, Nicholas J. Vaver, Anjali A. Velamala, Evan Vendetti, Nancy Ortiz Venegas, Aditya V. Vepa, Marcus T. Vess, Jenna S. Veta, Andrew Victory, Jessica Vinson, Connor Maklain Vogel, Michaela Wagoner, Steven P. Wallace, Logan Wallace, Caroline Waller, Jiawei Wang, Keenan Warble, N. R. D. Ward-Chene, James Adam Watson, Robert J. Weber, Aidan B. Wegner, Anthony A Weigand, Amanda M. Weiner, Ayana West, Ethan Benjamin Wexler, Nicola H. Wheeler, Jamison R. White, Zachary White, Oliver S. White, Lloyd C. Whittall, Isaac Wilcove, Blake C. Wilkinson, John S. Willard, Abigail K. Williams, Sajan Williams, Orion K. Wilson, Evan M. Wilson, Timothy R. Wilson, Connor B. Wilson, Briahn Witkoff, Aubrey M. Wolfe, Jackson R. Wolle, Travis M. Wood, Aiden L. Woodard, Katelynn Wootten, Catherine Xiao, Jianing Yang, Zhanchao Yang, Trenton J. Young, Isabel Young, Thomas Zenner, Jiaqi Zhang, Tianwei Zhao, Tiannie Zhao, Noah Y. Zhao, Chongrui Zhou, Josh J Ziebold, Lucas J. Ziegler, James C. Zygmunt, Jinhua Zhang, and H. J. Lewandowski

Subjects
Solar physics, Solar flares, Astrostatistics distributions, Astrophysics, QB460-466
Abstract

Flare frequency distributions represent a key approach to addressing one of the largest problems in solar and stellar physics: determining the mechanism that counterintuitively heats coronae to temperatures that are orders of magnitude hotter than the corresponding photospheres. It is widely accepted that the magnetic field is responsible for the heating, but there are two competing mechanisms that could explain it: nanoflares or Alfvén waves. To date, neither can be directly observed. Nanoflares are, by definition, extremely small, but their aggregate energy release could represent a substantial heating mechanism, presuming they are sufficiently abundant. One way to test this presumption is via the flare frequency distribution, which describes how often flares of various energies occur. If the slope of the power law fitting the flare frequency distribution is above a critical threshold, α = 2 as established in prior literature, then there should be a sufficient abundance of nanoflares to explain coronal heating. We performed >600 case studies of solar flares, made possible by an unprecedented number of data analysts via three semesters of an undergraduate physics laboratory course. This allowed us to include two crucial, but nontrivial, analysis methods: preflare baseline subtraction and computation of the flare energy, which requires determining flare start and stop times. We aggregated the results of these analyses into a statistical study to determine that α = 1.63 ± 0.03. This is below the critical threshold, suggesting that Alfvén waves are an important driver of coronal heating.

Published
2023
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175. Multisocietal European consensus on the terminology, diagnosis, and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, K, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Lang, H, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef K., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Lang H., Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F. M., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., Artigas C., Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, K, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Lang, H, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef K., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Lang H., Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F. M., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., and Artigas C.

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases, with a focus on terminology, diagnosis, and management. Methods: This project was a multiorganizational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis, and management. Statements were refined during an online Delphi process, and those with 70 per cent agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising 12 key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term 'early metachronous metastases' applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour, the term 'late metachronous metastases' applies to those detected after 12 months. 'Disappearing metastases' applies to lesions that are no longer detectable on MRI after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards, and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways, including systemic chemotherapy, synchronous surgery, and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusion: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

176. The multi-societal European consensus on the terminology, diagnosis and management of patients with synchronous colorectal cancer and liver metastases: an E-AHPBA consensus in partnership with ESSO, ESCP, ESGAR, and CIRSE

Author

Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, C, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Hauke, L, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef C., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Hauke Lang, Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., Artigas C., Siriwardena, A, Serrablo, A, Fretland, A, Wigmore, S, Ramia-Angel, J, Malik, H, Stattner, S, Soreide, K, Zmora, O, Meijerink, M, Kartalis, N, Lesurtel, M, Verhoef, C, Balakrishnan, A, Gruenberger, T, Jonas, E, Devar, J, Jamdar, S, Jones, R, Hilal, M, Andersson, B, Boudjema, K, Mullamitha, S, Stassen, L, Dasari, B, Frampton, A, Aldrighetti, L, Pellino, G, Buchwald, P, Gurses, B, Wasserberg, N, Gruenberger, B, Spiers, H, Jarnagin, W, Vauthey, J, Kokudo, N, Tejpar, S, Valdivieso, A, Adam, R, Hauke, L, Smith, M, Deoliveira, M, Adair, A, Gilg, S, Swijnenburg, R, Jaekers, J, Jegatheeswaran, S, Buis, C, Parks, R, Bockhorn, M, Conroy, T, Petras, P, Primavesi, F, Chan, A, Cipriani, F, Rubbia-Brandt, L, Foster, L, Abdelaal, A, Yaqub, S, Rahbari, N, Fondevila, C, Abradelo, M, Kok, N, Tejedor, L, Martinez-Baena, D, Azoulay, D, Maglione, M, Serradilla-Martin, M, Azevedo, J, Romano, F, Line, P, Forcen, T, Panis, Y, Stylianides, N, Bale, R, Quaia, E, Yassin, N, Duque, V, Espin-Basany, E, Mellenhorst, J, Rees, A, Adeyeye, A, Tuynman, J, Simillis, C, Duff, S, Wilson, R, De Nardi, P, Palmer, G, Zakaria, A, Perra, T, Porcu, A, Tamini, N, Kelly, M, Metwally, I, Morarasu, S, Carbone, F, Estaire-Gomez, M, Perez, E, Seligmann, J, Gollins, S, Braun, M, Hessheimer, A, Alonso, V, Radhakrishna, G, Alam, N, Camposorias, C, Barriuoso, J, Ross, P, Ba-Ssalamah, A, Muthu, S, Filobbos, R, Nadarajah, V, Hattab, A, Newton, C, Barker, S, Sibbald, J, Hancock, J, de Liguori Carino, N, Deshpande, R, Lancellotti, F, Paterna, S, Gutierrez-Diez, M, Artigas, C, Siriwardena A. K., Serrablo A., Fretland A. A., Wigmore S. J., Ramia-Angel J. M., Malik H. Z., Stattner S., Soreide K., Zmora O., Meijerink M., Kartalis N., Lesurtel M., Verhoef C., Balakrishnan A., Gruenberger T., Jonas E., Devar J., Jamdar S., Jones R., Hilal M. A., Andersson B., Boudjema K., Mullamitha S., Stassen L., Dasari B. V. M., Frampton A. E., Aldrighetti L., Pellino G., Buchwald P., Gurses B., Wasserberg N., Gruenberger B., Spiers H. V. M., Jarnagin W., Vauthey J. -N., Kokudo N., Tejpar S., Valdivieso A., Adam R., Hauke Lang, Smith M., deOliveira M. L., Adair A., Gilg S., Swijnenburg R. -J., Jaekers J., Jegatheeswaran S., Buis C., Parks R., Bockhorn M., Conroy T., Petras P., Primavesi F., Chan A. K. C., Cipriani F., Rubbia-Brandt L., Foster L., Abdelaal A., Yaqub S., Rahbari N., Fondevila C., Abradelo M., Kok N. F., Tejedor L., Martinez-Baena D., Azoulay D., Maglione M., Serradilla-Martin M., Azevedo J., Romano F., Line P. -D., Forcen T. A., Panis Y., Stylianides N., Bale R., Quaia E., Yassin N., Duque V., Espin-Basany E., Mellenhorst J., Rees A., Adeyeye A., Tuynman J. B., Simillis C., Duff S., Wilson R., De Nardi P., Palmer G. J., Zakaria A. D., Perra T., Porcu A., Tamini N., Kelly M. E., Metwally I., Morarasu S., Carbone F., Estaire-Gomez M., Perez E. M., Seligmann J., Gollins S., Braun M., Hessheimer A., Alonso V., Radhakrishna G., Alam N., Camposorias C., Barriuoso J., Ross P., Ba-Ssalamah A., Muthu S., Filobbos R., Nadarajah V., Hattab A., Newton C., Barker S., Sibbald J., Hancock J., de Liguori Carino N., Deshpande R., Lancellotti F., Paterna S., Gutierrez-Diez M., and Artigas C.

Abstract

Background: Contemporary management of patients with synchronous colorectal cancer and liver metastases is complex. The aim of this project was to provide a practical framework for care of patients with synchronous colorectal cancer and liver metastases with a focus on terminology, diagnosis and management. Methods: This project was a multi-organisational, multidisciplinary consensus. The consensus group produced statements which focused on terminology, diagnosis and management. Statements were refined during an online Delphi process and those with 70% agreement or above were reviewed at a final meeting. Iterations of the report were shared by electronic mail to arrive at a final agreed document comprising twelve key statements. Results: Synchronous liver metastases are those detected at the time of presentation of the primary tumour. The term “early metachronous metastases” applies to those absent at presentation but detected within 12 months of diagnosis of the primary tumour with “late metachronous metastases” applied to those detected after 12 months. Disappearing metastases applies to lesions which are no longer detectable on MR scan after systemic chemotherapy. Guidance was provided on the recommended composition of tumour boards and clinical assessment in emergency and elective settings. The consensus focused on treatment pathways including systemic chemotherapy, synchronous surgery and the staged approach with either colorectal or liver-directed surgery as first step. Management of pulmonary metastases and the role of minimally invasive surgery was discussed. Conclusions: The recommendations of this contemporary consensus provide information of practical value to clinicians managing patients with synchronous colorectal cancer and liver metastases.

Published
2023

177. Cluster Glasses of Semiflexible Ring Polymers

Author

Slimani, Mohammed Zakaria, Bacova, Petra, Bernabei, Marco, Narros, Arturo, Likos, Christos N., and Moreno, Angel J.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We present computer simulations of concentrated solutions of unknotted nonconcatenated semiflexible ring polymers. Unlike in their flexible counterparts, shrinking involves a strong energetic penalty, favoring interpenetration and clustering of the rings. We investigate the slow dynamics of the centers-of-mass of the rings in the amorphous cluster phase, consisting of disordered columns of oblate rings penetrated by bundles of prolate ones. Scattering functions reveal a striking decoupling of self- and collective motions. Correlations between centers-of-mass exhibit slow relaxation, as expected for an incipient glass transition, indicating the dynamic arrest of the cluster positions. However, self-correlations decay at much shorter time scales. This feature is a manifestation of the fast, continuous exchange and diffusion of the individual rings over the matrix of clusters. Our results reveal a novel scenario of glass-formation in a simple monodisperse system, characterized by self-collective decoupling, soft caging and mild dynamic heterogeneity., Comment: Revised version and Supplementary Material

Published
2013

178. Real-space renormalization group method for quantum 1/2 spins on the pyrochlore lattice

Author

Garcia-Adeva, Angel J.

Subjects
Condensed Matter - Statistical Mechanics
Abstract

A simple phenomenological real-space renormalization group method for quantum Heisenberg spins with nearest and next nearest neighbour interactions on a pyrochlore lattice is presented. Assuming a scaling law for the order parameter of two clusters of different sizes a set of coupled equations that gives the fixed points of the renormalization group transformation and, thus, the critical temperatures and ordered phases of the system is found. The particular case of spins $\frac{1}{2}$ is studied in detail. Furthermore, to simplify the mathematical details, from all the possible phases arising from the renormalization group transformation, only those phases in which the magnetic lattice is commensurate with a subdivision of the crystal lattice into four interlocked fcc sublattices are considered. These correspond to a quantum spin liquid, ferromagnetic order, or non-collinear order in which the total magnetic moment of a tetrahedral unit is zero. The corresponding phase diagram is constructed and the differences with respect to the classical model are analysed. It is found that this method reproduces fairly well the phase diagram of the pyrochlore lattice under the aforementioned constrains., Comment: 18 pages, 1 figure

Published
2013

184. Biopsychosocial Factors of Depression Among Hispanic Women Aged ≥50 Years

Author

Giovanna De Oliveira, Rosina Cianelli, Angel J. Solorzano Martinez, Natalia Villegas, and Evelyn Iriarte

Subjects
Pshychiatric Mental Health, General Nursing
Abstract

The purpose of the current study was to identify biopsychosocial factors associated with depressive symptoms among Hispanic women aged ≥50 years. Cross-sectional data related to 10 biological, psychological, and social factors were analyzed. Center for Epidemiologic Studies Depression Scale scores suggested that 32% of the sample had depressive symptoms. Self-esteem, self-perception of health status, income, and chronic pain had statistically significant associations with depressive symptoms. A logistic regression analysis showed that increasing self-esteem scores were associated with decreases in the likelihood of having depressive symptoms. Findings underscore that depression is associated with biological, psychological, and social factors. Culturally tailored interventions that aim at targeting these factors may have an impact on Hispanic women's depression and overall well-being. [ Journal of Psychosocial Nursing and Mental Health Services, xx (x), xx–xx.]

Published
2023

188. Alternative Excipients for Protein Stabilization in Protein Therapeutics: Overcoming the Limitations of Polysorbates

Author

Angel J. Castañeda Ruiz, Maryam A. Shetab Boushehri, Tamara Phan, Stefan Carle, Patrick Garidel, Julia Buske, and Alf Lamprecht

Subjects
polysorbate alternatives, excipient, surfactant, protein stabilization, protein biotherapeutic formulations, Pharmacy and materia medica, RS1-441
Abstract

Given their safety and efficiency in protecting protein integrity, polysorbates (PSs) have been the most widely used excipients for the stabilization of protein therapeutics for years. In recent decades, however, there have been numerous reports about visible or sub-visible particles in PS-containing biotherapeutic products, which is a major quality concern for parenteral drugs. Alternative excipients that are safe for parenteral administration, efficient in protecting different protein drugs against various stress conditions, effective in protein stabilization in high-concentrated liquid formulations, stable under the storage conditions for the duration of the product’s shelf-life, and compatible with other formulation components and the primary packaging are highly sought after. The aim of this paper is to review potential alternative excipients from different families, including surfactants, carbohydrate- and amino acid-based excipients, synthetic amphiphilic polymers, and ionic liquids that enable protein stabilization. For each category, important characteristics such as the ability to stabilize proteins against thermal and mechanical stresses, current knowledge related to the safety profile for parenteral administration, potential interactions with other formulation components, and primary packaging are debated. Based on the provided information and the detailed discussion thereof, this paper may pave the way for the identification or development of efficient excipients for biotherapeutic protein stabilization.

Published
2022
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191. The finite element method applied to the study of two-dimensional photonic crystals

Author

Andonegui, Imanol and Garcia-Adeva, Angel J.

Subjects
Condensed Matter - Mesoscale and Nanoscale Physics, Physics - Optics
Abstract

Calculations of the photonic band structure, transmission coefficients, and quality factors of various two-dimensional, periodic and aperiodic, dielectric photonic crystals by using the finite element method (FEM) are reported. The fundamental equations governing the propagation of electromagnetic waves in inhomogeneous media are revisited together with the boundary conditions required for each of the performed calculations. A detailed account of the eigenvalue and harmonic propagation analysis of the electromagnetic problem is reported for several periodic and finite-length structures. It is found that this method reproduces quite well previous results for these lattices obtained with the standard plane wave method with regards to the eigenvalue analysis (photonic band structure calculations). However, in contrast with frequency methods, the finite element method easily allows one to study the time-harmonic propagation of electromagnetic fields and, thus, to calculate the transmission coefficient of finite clusters in a natural way. Moreover, the advantages of using this real space method for structures of arbitrary complexity are also discussed. In addition, point defect cluster quality factor calculations are reported by means of FEM and they are compared to the ones obtained with the FDTD and \texttt{Harminv} methods. As a result, FEM comes out as an effective, stable, robust, and rigorous tool to study light propagation and confinement in both periodic and aperiodic dielectric photonic crystals., Comment: 13 pages, 8 figures

Published
2012
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192. Cluster glasses of ultrasoft particles

Author

Coslovich, Daniele, Bernabei, Marco, and Moreno, Angel J.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We present molecular dynamics (MD) simulations results for dense fluids of ultrasoft, fully-penetrable particles. These are a binary mixture and a polydisperse system of particles interacting via the generalized exponential model, which is known to yield cluster crystal phases for the corresponding monodisperse systems. Because of the dispersity in the particle size, the systems investigated in this work do not crystallize and form disordered cluster phases. The clustering transition appears as a smooth crossover to a regime in which particles are mostly located in clusters, isolated particles being infrequent. The analysis of the internal cluster structure reveals microsegregation of the big and small particles, with a strong homo-coordination in the binary mixture. Upon further lowering the temperature below the clustering transition, the motion of the clusters' centers-of-mass slows down dramatically, giving way to a cluster glass transition. In the cluster glass, the diffusivities remain finite and display an activated temperature dependence, indicating that relaxation in the cluster glass occurs via particle hopping in a nearly arrested matrix of clusters. Finally we discuss the influence of the microscopic dynamics on the transport properties by comparing the MD results with Monte Carlo simulations., Comment: 17 pages, 23 figures

Published
2012
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193. Anomalous Molecular Weight Dependence of Chain Dynamics in Unentangled Polymer Blends with Strong Dynamic Asymmetry

Author

Arrese-Igor, Silvia, Alegria, Angel, Moreno, Angel J., and Colmenero, Juan

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We address the general question of how the molecular weight dependence of chain dynamics in unentangled polymers is modified by blending. By dielectric spectroscopy we measure the normal mode relaxation of polyisoprene in blends with a slow matrix of poly(ter-butylstyrene). Unentangled polyisoprene in the blend exhibits strong deviations from Rouse scaling, approaching 'entangled-like' behavior at low temperatures in concomitance with the increase of the dynamic asymmetry in the blend. The obtained results are discussed in the framework of the generalized Langevin equation formalism. On this basis, a non trivial relationship between the molecular weight dependence of the longest chain relaxation time and the nonexponentiality of the corresponding Rouse correlator is found. This result is confirmed by molecular dynamics simulations., Comment: To be published in Soft Matter. Withdrawn following editorial requirements

Published
2011

194. Static and dynamic contributions to anomalous chain dynamics in polymer blends

Author

Bernabei, Marco, Moreno, Angel J., and Colmenero, Juan

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

By means of computer simulations, we investigate the relaxation of the Rouse modes in a simple bead-spring model for non-entangled polymer blends. Two different models are used for the fast component, namely fully-flexible and semiflexible chains. The latter are semiflexible in the meaning that static intrachain correlations are strongly non-gaussian at all length scales. The dynamic asymmetry in the blend is strongly enhanced by decreasing temperature, inducing confinement effects on the fast component. The dynamics of the Rouse modes show very different trends for the two models of the fast component. For the fully-flexible case, the relaxation times exhibit a progressive deviation from Rouse scaling on increasing the dynamic asymmetry. This anomalous effect has a dynamic origin. It is not related to particular static features of the Rouse modes, which indeed are identical to those of the fully-flexible homopolymer, and are not modified by the dynamic asymmetry in the blend. On the contrary, in the semiflexible case the relaxation times exhibit approximately the same scaling behaviour as the amplitudes of the modes. This suggests that the origin of the anomalous dynamic scaling for semiflexible chains confined in the blend is esentially of static nature. We discuss implications of these observations for the applicability of theoretical approaches to chain dynamics in polymer blends., Comment: 15 pages (single-column), 6 figures

Published
2010
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195. Increasing the density melts ultrasoft colloidal glasses

Author

Berthier, Ludovic, Moreno, Angel J., and Szamel, Grzegorz

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We use theory and simulations to investigate the existence of amorphous glassy states in ultrasoft colloids. We combine the hyper-netted chain approximation with mode-coupling theory to study the dynamic phase diagram of soft repulsive spheres interacting with a Hertzian potential, focusing on low temperatures and large densities. At constant temperature, we find that an amorphous glassy state is entered upon compression, as in colloidal hard spheres, but the glass unexpectedly melts when density increases further. We attribute this re-entrant fluid-glass transition to particle softness, and correlate this behaviour to previously reported anomalies in soft systems, thus emphasizing its generality. The predicted fluid-glass-fluid sequence is confirmed numerically., Comment: 4 pages, 3 figs

Published
2010
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196. Dynamics in binary cluster crystals

Author

Camargo, Manuel, Moreno, Angel J., and Likos, Christos N.

Subjects
Condensed Matter - Soft Condensed Matter, Physics - Computational Physics
Abstract

As a result of the application of coarse-graining procedures to describe complex fluids, the study of systems consisting of particles interacting through bounded, repulsive pair potentials has become of increasing interest in the last years. A well known example is the so-called Generalized Exponential Model (GEM-$m$), for which the interaction between particles is described by the potential $v(r)=\epsilon\exp[-(r/\sigma)^m]$. Interactions with $m > 2$ lead to the formation of a novel phase of soft matter consisting of cluster crystals. Recent studies on the phase behavior of binary mixtures of GEM-$m$ particles have provided evidence for the formation of novel kinds of alloys, depending on the cross interactions between the two species. This work aims to study the dynamic behavior of such binary mixtures by means of extensive molecular dynamics simulations, and in particular to investigate the effect of the addition of non-clustering particles on the dynamic scenario of one-component cluster crystals. Analogies and differences with the one-component case are revealed and discussed by analyzing self- and collective dynamic correlators., Comment: 17 pages, 8 figures, submitted to JSTAT

Published
2010
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197. From caging to Rouse dynamics in polymer melts with intramolecular barriers: a critical test of the Mode Coupling Theory

Author

Bernabei, Marco, Moreno, Angel J., Zaccarelli, Emanuela, Sciortino, Francesco, and Colmenero, Juan

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

By means of computer simulations and solution of the equations of the Mode Coupling Theory (MCT), we investigate the role of the intramolecular barriers on several dynamic aspects of non-entangled polymers. The investigated dynamic range extends from the caging regime characteristic of glass-formers to the relaxation of the chain Rouse modes. We review our recent work on this question, provide new results and critically discuss the limitations of the theory. Solutions of the MCT for the structural relaxation reproduce qualitative trends of simulations for weak and moderate barriers. However a progressive discrepancy is revealed as the limit of stiff chains is approached. This disagreement does not seem related with dynamic heterogeneities, which indeed are not enhanced by increasing barrier strength. It is not connected either with the breakdown of the convolution approximation for three-point static correlations, which retains its validity for stiff chains. These findings suggest the need of an improvement of the MCT equations for polymer melts. Concerning the relaxation of the chain degrees of freedom, MCT provides a microscopic basis for time scales from chain reorientation down to the caging regime. It rationalizes, from first principles, the observed devations from the Rouse model on increasing the barrier strength. These include anomalous scaling of relaxation times, long-time plateaux, and non-monotonous wavelength dependence of the mode correlators., Comment: 15 pages, 14 figures

Published
2010
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198. LSST Science Book, Version 2.0

Author

LSST Science Collaboration, Abell, Paul A., Allison, Julius, Anderson, Scott F., Andrew, John R., Angel, J. Roger P., Armus, Lee, Arnett, David, Asztalos, S. J., Axelrod, Tim S., Bailey, Stephen, Ballantyne, D. R., Bankert, Justin R., Barkhouse, Wayne A., Barr, Jeffrey D., Barrientos, L. Felipe, Barth, Aaron J., Bartlett, James G., Becker, Andrew C., Becla, Jacek, Beers, Timothy C., Bernstein, Joseph P., Biswas, Rahul, Blanton, Michael R., Bloom, Joshua S., Bochanski, John J., Boeshaar, Pat, Borne, Kirk D., Bradac, Marusa, Brandt, W. N., Bridge, Carrie R., Brown, Michael E., Brunner, Robert J., Bullock, James S., Burgasser, Adam J., Burge, James H., Burke, David L., Cargile, Phillip A., Chandrasekharan, Srinivasan, Chartas, George, Chesley, Steven R., Chu, You-Hua, Cinabro, David, Claire, Mark W., Claver, Charles F., Clowe, Douglas, Connolly, A. J., Cook, Kem H., Cooke, Jeff, Cooray, Asantha, Covey, Kevin R., Culliton, Christopher S., de Jong, Roelof, de Vries, Willem H., Debattista, Victor P., Delgado, Francisco, Dell'Antonio, Ian P., Dhital, Saurav, Di Stefano, Rosanne, Dickinson, Mark, Dilday, Benjamin, Djorgovski, S. G., Dobler, Gregory, Donalek, Ciro, Dubois-Felsmann, Gregory, Durech, Josef, Eliasdottir, Ardis, Eracleous, Michael, Eyer, Laurent, Falco, Emilio E., Fan, Xiaohui, Fassnacht, Christopher D., Ferguson, Harry C., Fernandez, Yanga R., Fields, Brian D., Finkbeiner, Douglas, Figueroa, Eduardo E., Fox, Derek B., Francke, Harold, Frank, James S., Frieman, Josh, Fromenteau, Sebastien, Furqan, Muhammad, Galaz, Gaspar, Gal-Yam, A., Garnavich, Peter, Gawiser, Eric, Geary, John, Gee, Perry, Gibson, Robert R., Gilmore, Kirk, Grace, Emily A., Green, Richard F., Gressler, William J., Grillmair, Carl J., Habib, Salman, Haggerty, J. S., Hamuy, Mario, Harris, Alan W., Hawley, Suzanne L., Heavens, Alan F., Hebb, Leslie, Henry, Todd J., Hileman, Edward, Hilton, Eric J., Hoadley, Keri, Holberg, J. B., Holman, Matt J., Howell, Steve B., Infante, Leopoldo, Ivezic, Zeljko, Jacoby, Suzanne H., Jain, Bhuvnesh, Jedicke, Jee, M. James, Jernigan, J. Garrett, Jha, Saurabh W., Johnston, Kathryn V., Jones, R. Lynne, Juric, Mario, Kaasalainen, Mikko, Styliani, Kafka, Kahn, Steven M., Kaib, Nathan A., Kalirai, Jason, Kantor, Jeff, Kasliwal, Mansi M., Keeton, Charles R., Kessler, Richard, Knezevic, Zoran, Kowalski, Adam, Krabbendam, Victor L., Krughoff, K. Simon, Kulkarni, Shrinivas, Kuhlman, Stephen, Lacy, Mark, Lepine, Sebastien, Liang, Ming, Lien, Amy, Lira, Paulina, Long, Knox S., Lorenz, Suzanne, Lotz, Jennifer M., Lupton, R. H., Lutz, Julie, Macri, Lucas M., Mahabal, Ashish A., Mandelbaum, Rachel, Marshall, Phil, May, Morgan, McGehee, Peregrine M., Meadows, Brian T., Meert, Alan, Milani, Andrea, Miller, Christopher J., Miller, Michelle, Mills, David, Minniti, Dante, Monet, David, Mukadam, Anjum S., Nakar, Ehud, Neill, Douglas R., Newman, Jeffrey A., Nikolaev, Sergei, Nordby, Martin, O'Connor, Paul, Oguri, Masamune, Oliver, John, Olivier, Scot S., Olsen, Julia K., Olsen, Knut, Olszewski, Edward W., Oluseyi, Hakeem, Padilla, Nelson D., Parker, Alex, Pepper, Joshua, Peterson, John R., Petry, Catherine, Pinto, Philip A., Pizagno, James L., Popescu, Bogdan, Prsa, Andrej, Radcka, Veljko, Raddick, M. Jordan, Rasmussen, Andrew, Rau, Arne, Rho, Jeonghee, Rhoads, James E., Richards, Gordon T., Ridgway, Stephen T., Robertson, Brant E., Roskar, Rok, Saha, Abhijit, Sarajedini, Ata, Scannapieco, Evan, Schalk, Terry, Schindler, Rafe, Schmidt, Samuel, Schmidt, Sarah, Schneider, Donald P., Schumacher, German, Scranton, Ryan, Sebag, Jacques, Seppala, Lynn G., Shemmer, Ohad, Simon, Joshua D., Sivertz, M., Smith, Howard A., Smith, J. Allyn, Smith, Nathan, Spitz, Anna H., Stanford, Adam, Stassun, Keivan G., Strader, Jay, Strauss, Michael A., Stubbs, Christopher W., Sweeney, Donald W., Szalay, Alex, Szkody, Paula, Takada, Masahiro, Thorman, Paul, Trilling, David E., Trimble, Virginia, Tyson, Anthony, Van Berg, Richard, Berk, Daniel Vanden, VanderPlas, Jake, Verde, Licia, Vrsnak, Bojan, Walkowicz, Lucianne M., Wandelt, Benjamin D., Wang, Sheng, Wang, Yun, Warner, Michael, Wechsler, Risa H., West, Andrew A., Wiecha, Oliver, Williams, Benjamin F., Willman, Beth, Wittman, David, Wolff, Sidney C., Wood-Vasey, W. Michael, Wozniak, Przemek, Young, Patrick, Zentner, Andrew, and Zhan, Hu

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Cosmology and Extragalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Galaxy Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy., Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/scibook

Published
2009

199. The Role of Intramolecular Barriers on the Glass Transition of Polymers: Computer Simulations vs. Mode Coupling Theory

Author

Bernabei, Marco, Moreno, Angel J., and Colmenero, Juan

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

We present computer simulations of a simple bead-spring model for polymer melts with intramolecular barriers. By systematically tuning the strength of the barriers, we investigate their role on the glass transition. Dynamic observables are analyzed within the framework of the Mode Coupling Theory (MCT). Critical nonergodicity parameters, critical temperatures and dynamic exponents are obtained from consistent fits of simulation data to MCT asymptotic laws. The so-obtained MCT $\lambda$-exponent increases from standard values for fully-flexible chains to values close to the upper limit for stiff chains. In analogy with systems exhibiting higher-order MCT transitions, we suggest that the observed large $\lambda$-values arise form the interplay between two distinct mechanisms for dynamic arrest: general packing effects and polymer-specific intramolecular barriers. We compare simulation results with numerical solutions of the MCT equations for polymer systems, within the polymer reference interaction site model (PRISM) for static correlations. We verify that the approximations introduced by the PRISM are fulfilled by simulations, with the same quality for all the range of investigated barrier strength. The numerical solutions reproduce the qualitative trends of simulations for the dependence of the nonergodicity parameters and critical temperatures on the barrier strength. In particular, the increase of the barrier strength at fixed density increases the localization length and the critical temperature. However the qualitative agreement between theory and simulation breaks in the limit of stiff chains. We discuss the possible origin of this feature.

Published
2009
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200. Faster Region Convolutional Neural Network (FRCNN) Based Facial Emotion Recognition.

Author

Sheril Angel, J., Diana Andrushia, A., Mary Neebha, T., Accouche, Oussama, Saker, Louai, and Anand, N.

Abstract

Facial emotion recognition (FER) has become a focal point of research due to its widespread applications, ranging from human-computer interaction to affective computing. While traditional FER techniques have relied on handcrafted features and classification models trained on image or video datasets, recent strides in artificial intelligence and deep learning (DL) have ushered in more sophisticated approaches. The research aims to develop a FER system using a Faster Region Convolutional Neural Network (FRCNN) and design a specialized FRCNN architecture tailored for facial emotion recognition, leveraging its ability to capture spatial hierarchies within localized regions of facial features. The proposed work enhances the accuracy and efficiency of facial emotion recognition. The proposed work comprises twomajor key components: Inception V3-based feature extraction and FRCNN-based emotion categorization. Extensive experimentation on Kaggle datasets validates the effectiveness of the proposed strategy, showcasing the FRCNN approach's resilience and accuracy in identifying and categorizing facial expressions. The model's overall performance metrics are compelling, with an accuracy of 98.4%, precision of 97.2%, and recall of 96.31%. This work introduces a perceptive deep learning-based FER method, contributing to the evolving landscape of emotion recognition technologies. The high accuracy and resilience demonstrated by the FRCNN approach underscore its potential for real-world applications. This research advances the field of FER and presents a compelling case for the practicality and efficacy of deep learning models in automating the understanding of facial emotions. [ABSTRACT FROM AUTHOR]

Published
2024
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