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154. Efficacy of rituximab in refractory RRMS

Author

Durozard, Pierre, primary, Maarouf, Adil, additional, Boutiere, Clémence, additional, Ruet, Aurelie, additional, Brochet, Bruno, additional, Vukusic, Sandra, additional, Carra-Dalliere, Clarisse, additional, Labauge, Pierre, additional, Mathey, Guillaume, additional, Debouverie, Marc, additional, Papeix, Caroline, additional, Maillart, Elisabeth, additional, Lubetzki, Catherine, additional, Bensa, Caroline, additional, Gout, Olivier, additional, Giannesini, Claire, additional, Stankoff, Bruno, additional, Ciron, Jonathan, additional, Brassat, David, additional, Pelletier, Jean, additional, Rico Lamy, Audrey, additional, and Audoin, Bertrand, additional

Published
2018
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155. RITUXIMAB AS RESCUE THERAPY IN RRMS PATIENTS WITH DISEASE ACTIVITY DESPITE SECOND-LINE TREATMENT (P5.428)

Author

Durozard, Pierre, primary, Maarouf, Adil, additional, Boutiere, Clémence, additional, Ruet, Aurelie, additional, Brochet, Bruno, additional, Vukusic, Sandra, additional, Carra-Dalliere, Clarisse, additional, Labauge, Pierre, additional, Mathey, Guillaume, additional, Debouverie, Marc, additional, Papeix, Caroline, additional, Maillart, Elisabeth, additional, Lubetzki, Catherine, additional, Bensa, Caroline, additional, Gout, Olivier, additional, Giannesini, Claire, additional, Stankoff, Bruno, additional, Brassat, David, additional, Lamy, Audrey Rico, additional, Pelletier, Jean, additional, and Audoin, Bertrand, additional

Published
2018
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156. Treatment of MOG-IgG-associated demyelination with Rituximab: a multinational study of 98 patients (S13.003)

Author

Whittam, Daniel, primary, Cobo-Calvo, Alvaro, additional, Lopez-Chiriboga, Alfonso Sebastian, additional, Pardo, Santiago, additional, Dodd, James, additional, Brandt, Alexander, additional, Berek, Klaus, additional, Berger, Thomas, additional, Gombolay, Grace, additional, Oliveira, Luana Micheli, additional, Callegaro, Dagoberto, additional, Kaneko, Kimihiko, additional, Misu, Tatsuro, additional, Brochet, Bruno, additional, Audoin, Bertrand, additional, Mathey, Guillaume, additional, Laplaud, David, additional, Thouvenot, Eric, additional, Cohen, Mikael, additional, Tourbah, Ayman, additional, Maillart, Elisabeth, additional, Ciron, Jonathan, additional, Deschamps, Romain, additional, Biotti, Damien, additional, Matiello, Marcelo, additional, Palace, Jacqueline, additional, Lim, Ming, additional, Fujihara, Kazuo, additional, Nakashima, Ichiro, additional, Bennett, Jeffrey, additional, Pandit, Lekha, additional, Chitnis, Tanuja, additional, Weinshenker, Brian, additional, Wildemann, Brigitte, additional, Sato, Douglas Kazutoshi, additional, Kim, Su-Hyun, additional, Kim, Ho Jin, additional, Reindl, Markus, additional, Levy, Michael, additional, Jarius, Sven, additional, Tenembaum, Silvia, additional, Paul, Friedemann, additional, Pittock, Sean, additional, Marignier, Romain, additional, and Jacob, Anu, additional

Published
2018
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157. Column-specific demyelination in Spinal Cord Normal Appearing White Matter occurring in Multiple Sclerosis: A preliminary study using inhomogeneous Magnetization Transfer and DTI (P3.382)

Author

RASOANANDRIANINA, Henitsoa, primary, AUDOIN, Bertrand, additional, TASO, Manuel, additional, GIRARD, Olivier, additional, DUHAMEL, Guillaume, additional, PINI, Lauriane, additional, DEMORTIERE, Sarah, additional, GUYE, Maxime, additional, RANJEVA, Jean-Philippe, additional, PELLETIER, Jean, additional, and CALLOT, Virginie, additional

Published
2018
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162. Mind the gap: from neurons to networks to outcomes in multiple sclerosis

Author

Chard, Declan T., Alahmadi, Adnan A. S., Audoin, Bertrand, Charalambous, Thalis, Enzinger, Christian, Hulst, Hanneke E., Rocca, Maria A., Rovira, Àlex, Sastre-Garriga, Jaume, Schoonheim, Menno M., Tijms, Betty, Tur, Carmen, Gandini Wheeler-Kingshott, Claudia A. M., Wink, Alle Meije, Ciccarelli, Olga, and Barkhof, Frederik

Abstract

MRI studies have provided valuable insights into the structure and function of neural networks, particularly in health and in classical neurodegenerative conditions such as Alzheimer disease. However, such work is also highly relevant in other diseases of the CNS, including multiple sclerosis (MS). In this Review, we consider the effects of MS pathology on brain networks, as assessed using MRI, and how these changes to brain networks translate into clinical impairments. We also discuss how this knowledge can inform the targeting of MS treatments and the potential future directions for research in this area. Studying MS is challenging as its pathology involves neurodegenerative and focal inflammatory elements, both of which could disrupt neural networks. The disruption of white matter tracts in MS is reflected in changes in network efficiency, an increasingly random grey matter network topology, relative cortical disconnection, and both increases and decreases in connectivity centred around hubs such as the thalamus and the default mode network. The results of initial longitudinal studies suggest that these changes evolve rather than simply increase over time and are linked with clinical features. Studies have also identified a potential role for treatments that functionally modify neural networks as opposed to altering their structure.

Published
2021
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163. Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis

Author

Donadieu, Maxime, Le Fur, Yann, Lecocq, Angèle, Maudsley, Andrew A., Gherib, Soraya, Soulier, Elisabeth, Confort-Gouny, Sylviane, Pariollaud, Fanelly, Ranjeva, Marie-Pierre, Pelletier, Jean, Guye, Maxime, Zaaraoui, W, Audoin, Bertrand, Ranjeva, Jean-Philippe, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Centre d'Exploration Métabolique par Résonance Magnétique [Marseille] (CEMEREM), and Hôpital de la Timone [CHU - APHM] (TIMONE)

Subjects
Adult, Male, Magnetic Resonance Spectroscopy, Multiple Sclerosis, statistical mapping analysis, Sensitivity and Specificity, Article, Young Adult, Imaging, Three-Dimensional, Image Interpretation, Computer-Assisted, crmbm, Humans, Tissue Distribution, Observer Variation, Inflammation, proton magnetic resonance spectroscopic imaging, neurodegeneration, Brain, Reproducibility of Results, Signal Processing, Computer-Assisted, Middle Aged, Image Enhancement, Magnetic Resonance Imaging, Molecular Imaging, whole brain, Feasibility Studies, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Biomarkers
Abstract

International audience; PURPOSE: To detect local metabolic abnormalities over the complete human brain in multiple sclerosis (MS) patients, we used optimized fast volumic echo planar spectroscopic imaging (3D-EPSI). MATERIALS AND METHODS: Weighted mean combination of two 3D-EPSI covering the whole brain acquired at 3T in AC-PC and AC-PC+15° axial planes was performed to obtain high-quality metabolite maps for five metabolites: N-acetyl aspartate (NAA), glutamate+glutamine (Glx), choline (Cho), myo-inositol (m-Ins), and creatine+phosphocreatine (tCr). After spatial normalization, maps from 19 patients suffering from relapsing-remitting MS were compared to 19 matched controls using statistical mapping analyses to determine the topography of metabolic abnormalities. Probabilistic white matter (WM) T2 lesion maps and gray matter (GM) atrophy maps were also generated. RESULTS: Two-group analysis of variance (ANOVA) (SPM8, P \textless 0.005, false discovery rate [FDR]-corrected P \textless 0.05 at the cluster level with age and sex as confounding covariates) comparing patients and controls matched for age and sex showed clusters of abnormal metabolite levels with 1) decreased NAA (around -15%) and Glx (around 20%) predominantly in GM within prefrontal cortices, motor cortices, bilateral thalami, and mesial temporal cortices in line with neuronal/neuro-astrocytic dysfunction; 2) increased m-Ins (around + 20%) inside WM T2 lesions and in the normal-appearing WM of temporal-occipital lobes, suggesting glial activation. CONCLUSION: We demonstrate the ability to noninvasively map over the complete brain-from vertex to cerebellum-with a validated sequence, the metabolic abnormalities associated with MS, for characterizing the topography of pathological processes affecting widespread areas of WM and GM and its functional impact. J. Magn. Reson. Imaging 2016;44:411-419.

Published
2016

164. Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain 23Na-MRI and fast 1H-MRSI study

Author

Donadieu, Maxime, primary, Le Fur, Yann, additional, Maarouf, Adil, additional, Gherib, Soraya, additional, Ridley, Ben, additional, Pini, Lauriane, additional, Rapacchi, Stanislas, additional, Confort-Gouny, Sylviane, additional, Guye, Maxime, additional, Schad, Lothar R, additional, Maudsley, Andrew A, additional, Pelletier, Jean, additional, Audoin, Bertrand, additional, Zaaraoui, Wafaa, additional, and Ranjeva, Jean-Philippe, additional

Published
2017
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166. Monitoring CD27+ memory B-cells in neuromyelitis optica spectrum disorders patients treated with rituximab: results from a bicentric study (P6.389)

Author

Cohen, Mikael, primary, Romero, Gwendoline, additional, Bas, Joachim, additional, Ticchioni, Michel, additional, Rosenthal, Maria, additional, Lacroix, Romaric, additional, Brunet, Corinne, additional, Lamy, Audrey Rico, additional, Pelletier, Jean, additional, Audoin, Bertrand, additional, and Frenay, Christine Lebrun, additional

Published
2017
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167. Efficacy and safety of alemtuzumab in 113 patients with active relapsing-remitting MS: one-year follow-up in France (P5.347)

Author

Ayrignac, Xavier, primary, Collongues, Nicolas, additional, De Seze, Jerome, additional, Vermersch, Patrick, additional, Biotti, Damien, additional, BRASSAT, DAVID, additional, Vukusic, Sandra, additional, Durand-Dubief, Françoise, additional, Edan, Gilles, additional, Lepage, Emmanuelle, additional, Deburghgraeve, Veronique, additional, Maillart, Elisabeth, additional, Papeix, Caroline, additional, Alla, Philippe, additional, Berger, Eric, additional, Bourre, Bertrand, additional, Casez, Olivier, additional, Pittion, Sophie, additional, Debouverie, Marc, additional, Theaudin, Marie, additional, Derache, Nathalie, additional, Defer, Gilles, additional, Gout, Olivier, additional, Deschamps, Romain, additional, Tourbah, Ayman, additional, Zagnoli, Fabien, additional, Ruet, Aurelie, additional, Ouallet, Jean, additional, Brochet, Bruno, additional, Manchon, Eric, additional, Moreau, Thibault, additional, Fromont, Agnes, additional, Clavelou, Pierre, additional, Guennoc, Anne Marie, additional, Camdessanche, Jean-Phillippe, additional, Carpentier, Antoine, additional, Coman, Irene Antoanela, additional, Audoin, Bertrand, additional, Pelletier, Jean, additional, Magy, Laurent, additional, Ciron, Jonathan, additional, Wiertlevski, Sandrine, additional, Laplaud, David, additional, De Broucker, Thomas, additional, Frenay, Christine Lebrun, additional, Cohen, Mikael, additional, and Labauge, Pierre, additional

Published
2017
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168. Proposed revised criteria for the diagnosis of CLIPPERS (P1.329)

Author

Taieb, Guillaume, primary, Allou, Thibaut, additional, Kaphan, Elsa, additional, Audoin, Bertrand, additional, Pelletier, Jean, additional, Ouallet, Jean, additional, Desbordes, Patrice, additional, BRASSAT, DAVID, additional, Castelnovo, Giovanni, additional, Thouvenot, Eric, additional, Rigau, Valerie, additional, Arquizan, Caroline, additional, Ayrignac, Xavier, additional, Limousin, Nadege, additional, Loussouarn, Delphine, additional, Magy, Laurent, additional, Rousselot, Cecilia, additional, Lefaucheur, Romain, additional, De Seze, Jerome, additional, Tranchant, Christine, additional, Lebrun-Freney, Christine, additional, Bejot, Yannick, additional, Guiraud, Vincent, additional, Camdessanche, Jean-Phillippe, additional, Pico, Fernando, additional, van Oosten, Bob, additional, Kerschen, Philippe, additional, Fominykh, Vera, additional, Mulero, Patricia, additional, Tintore-Subirana, Maria, additional, Seebach, Joerg, additional, Psimaras, Dimitri, additional, Hoang-Xuan, Khe, additional, and Labauge, Pierre, additional

Published
2017
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170. Hypoperfusion of the thalamus is associated with disability in relapsing remitting multiple sclerosis

Author

Doche, Emilie, primary, Lecocq, Angèle, additional, Maarouf, Adil, additional, Duhamel, Guillaume, additional, Soulier, Elisabeth, additional, Confort-Gouny, Sylviane, additional, Rico, Audrey, additional, Guye, Maxime, additional, Audoin, Bertrand, additional, Pelletier, Jean, additional, Ranjeva, Jean-Philippe, additional, and Zaaraoui, Wafaa, additional

Published
2017
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172. APP Mutations in Cerebral Amyloid Angiopathy with or without Cortical Calcifications: Report of Three Families and a Literature Review

Author

Sellal, François, primary, Wallon, David, additional, Martinez-Almoyna, Laurent, additional, Marelli, Cecilia, additional, Dhar, Abhinav, additional, Oesterlé, Héléne, additional, Rovelet-Lecrux, Anne, additional, Rousseau, Stéphane, additional, Kourkoulis, Christina E., additional, Rosand, Jon, additional, DiPucchio, Zora Y., additional, Frosch, Matthew, additional, Gombert, Claudine, additional, Audoin, Bertrand, additional, Miné, Manuèle, additional, Riant, Florence, additional, Frebourg, Thierry, additional, Hannequin, Didier, additional, Campion, Dominique, additional, Greenberg, Steven M., additional, Tournier-Lasserve, Elisabeth, additional, and Nicolas, Gaël, additional

Published
2017
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173. Increased total sodium concentration in gray matter better explains cognition than atrophy in MS

Author

Maarouf, Adil, primary, Audoin, Bertrand, additional, Pariollaud, Fanelly, additional, Gherib, Soraya, additional, Rico, Audrey, additional, Soulier, Elisabeth, additional, Confort-Gouny, Sylviane, additional, Guye, Maxime, additional, Schad, Lothar, additional, Pelletier, Jean, additional, Ranjeva, Jean-Philippe, additional, and Zaaraoui, Wafaa, additional

Published
2016
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174. Propagation acoustique GHz dans le noyau de cellules biologiques : analogie avec les réseaux fibrés

Author

Dehoux, Thomas, Zouani, Omar, Durrieu, Marie-Christine, Audoin, Bertrand, Association Française de Mécanique, and Service irevues, irevues

Subjects
biologie cellulaire, [PHYS.MECA]Physics [physics]/Mechanics [physics], [PHYS.MECA] Physics [physics]/Mechanics [physics], acoustique picoseconde
Abstract

Colloque avec actes et comité de lecture. Internationale.; International audience; Nous utilisons la technique d'acoustique picoseconde pour sonder les propriétés mécaniques de cellules individuelles. Nous décrivons d'abord l'application à la paroi de cellules végétales dont la structure bien documentée nous sert de modèle pour comprendre la propagation acoustique GHz dans les réseaux biologiques fibreux. La comparaison avec un modèle d'homogénéisation révèle l'influence des liaisons d'hémicellulose, conduisant à un comportement iso-déformation où le réseau élastique de fibres de cellulose domine la réponse acoustique GHz. Nous étudions ensuite des cellules animales, et nous analysons les résultats par analogie avec ceux obtenus dans les cellules végétales. Un comportement iso-déformation est également identifié, cette fois-ci attribué à la présence de friction entre le réseau de fibres de chromatine et le liquide intra-nucléaire. Ces résultats offrent une meilleure compréhension des propriétés mécaniques du noyau, et permettront d'étudier la dynamique du réseau de chromatine pendant des processus cellulaires tels que la différentiation ou la morphogénèse.

Published
2015

175. A French observational study about treatment failure under fingolimod in 91 multiple sclerosis patients

Author

Carra Dallière, Clarisse, Fisselier, M., Cohen, M., Ayrignac, X., Le Page, E., Edan, Gilles, Burghgraeve, V., Papeix, C., Lubetzki, Catherine, Maillart, E., Seze, J., Collongues, N., Gout, O., Deschamps, R., Laplaud, David, Wiertlewski, S., Pelletier, Jean, Audoin, Bertrand, Brassat, D., Clanet, M., Peaureaux, D., Guennoc, A. -M., Ruet, A., Brochet, Bruno, Ouallet, J. -C., Debouverie, Marc, Pittion, S., Fromont, A., Moreau, Thibault, Taithe, F., Clavelou, Pierre, Zephyr, H., Outteryck, Olivier, Vermersch, Patrick, Charif, M., Thouvenot, Eric, Mazzola, L., Camdessanche, J. -P., Bourre, Bertrand, Lalu, T., Magy, L., Grimaud, J., Lebrun, C., Labauge, Pierre, Jonchère, Laurent, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Strasbourg, Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), and Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2015

176. All-optical broadband ultrasonography of single cells

Author

DEHOUX, Thomas, ABI GHANEM, Maroun, ZOUANI, Omar El-Farouk, RAMPNOUX, Jean-Michel, GUILLET, Yannick, DILHAIRE, Stefan, DURRIEU, Marie-Christine, AUDOIN, Bertrand, Institut de Mécanique et d'Ingénierie de Bordeaux (I2M), École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)-Institut National de la Recherche Agronomique (INRA), Chimie et Biologie des Membranes et des Nanoobjets (CBMN), École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Institut de Chimie du CNRS (INC)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Ondes et Matière d'Aquitaine (LOMA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Région Aquitaine, GIS Matériaux avancés en Aquitaine, ANR-13-BS09-0021,PicoBond,Imagerie quantitative par acoustique picoseconde de l'adhésion de cellules individuelles sur biomatériaux(2013), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Université Sciences et Technologies - Bordeaux 1-École Nationale d'Ingénieurs des Travaux Agricoles - Bordeaux (ENITAB)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)

Subjects
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], Biosensors, Cellular Imaging, [PHYS.PHYS.PHYS-BIO-PH]Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], Optical Imaging, Microscopy, Acoustic, Humans, Mesenchymal Stem Cells, Acoustics, Single-Cell Analysis, Cells, Cultured, Article, Ultrasonography
Abstract

International audience; Cell mechanics play a key role in several fundamental biological processes, such as migration, proliferation, differentiation and tissue morphogenesis. In addition, many diseased conditions of the cell are correlated with altered cell mechanics, as in the case of cancer progression. For this there is much interest in methods that can map mechanical properties with a sub-cell resolution. Here, we demonstrate an inverted pulsed opto-acoustic microscope (iPOM) that operates in the 10 to 100 GHz range. These frequencies allow mapping quantitatively cell structures as thin as 10 nm and resolving the fibrillar details of cells. Using this non-invasive all-optical system, we produce high-resolution images based on mechanical properties as the contrast mechanisms, and we can observe the stiffness and adhesion of single migrating stem cells. The technique should allow transferring the diagnostic and imaging abilities of ultrasonic imaging to the single-cell scale, thus opening new avenues for cell biology and biomaterial sciences.

Published
2015

177. OFSEP, a nationwide cohort of people with multiple sclerosis: Consensus minimal MRI protocol

Author

Amélie, Roxana, Anxionnat, René, Armspach, Jean-Paul, Audoin, Bertrand, Barillot, Christian, Berry, Isabelle, Bonneville, Fabrice, Boutet, Claire, Castelnovo, Giovanni, Cervenansky, Frédéric, Cohen, Mikael, Commowick, Olivier, Cotton, François, de Seze, Jérôme, Dousset, Vincent, Durand-Dubief, Françoise, Edan, Gilles, Ferre, Jean-Christophe, Galanaud, Damien, Glattard, Tristan, Grand, Sylvie, Guillaumont, Justine, Guillevin, Rémy, Guttmann, Charles, Hannoun, Salem, Heitz, Fabrice, Krainik, Alexandre, Kremer, Stéphane, Labauge, Pierre, Menjot de Champfleur, Nicolas, Ranjeva, Jean-Philippe, Roch, Jean-Amédée, Sappey-Marinier, Dominique, Savatovsky, Julien, Stankoff, Bruno, Tourdias, Thomas, Tourbah, Ayman, Vukusic, Sandra, Département de Neuroradiologie [Centre Hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), Visual Augmentation of Complex Environments (MAGRIT), INRIA Lorraine, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuroimagerie in Vivo (LNV), CHU Strasbourg-Centre National de la Recherche Scientifique (CNRS), Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Vision, Action et Gestion d'informations en Santé (VisAGeS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Inria Rennes – Bretagne Atlantique, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-SIGNAUX ET IMAGES NUMÉRIQUES, ROBOTIQUE (IRISA-D5), Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université Paris 1 Panthéon-Sorbonne (UP1), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Euromov (EuroMov), Université de Montpellier (UM), Service Informatique et développements, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Espaces, Nature et Culture (ENeC), Université Paris-Sorbonne (UP4)-Centre National de la Recherche Scientifique (CNRS), RMN et optique : De la mesure au biomarqueur, Service de Neurologie [Strasbourg], CHU Strasbourg-Hopital Civil, Physiopathologie du système nerveux central - Institut François Magendie, Université Bordeaux Segalen - Bordeaux 2-IFR8-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Neurologie [Lyon], CHU Lyon, Service de Neurologie [Rennes] = Neurology [Rennes], CHU Pontchaillou [Rennes], Service de radiologie et imagerie médicale [Rennes] = Radiology [Rennes], Neuro-imagerie fonctionnelle et métabolique (ANTE-INSERM U836, équipe 5), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Center for Neurological Imaging, Departments of Radiology and Neurology, Laboratoire des sciences de l'ingénieur, de l'informatique et de l'imagerie (ICube), École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Université de Strasbourg (UNISTRA)-Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de Recherche en Informatique et en Automatique (Inria)-Les Hôpitaux Universitaires de Strasbourg (HUS)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et Nanosciences Grand-Est (MNGE), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Strasbourg, CHU Montpellier, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Département de Neuroradiologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université de Montpellier (UM), Service de Radiologie [Hôpital de la Croix-Rousse - HCL], Hôpital de la Croix-Rousse [CHU - HCL], Centre d'Etude et de Recherche Multimodal Et Pluridisciplinaire en imagerie du vivant (CERMEP - imagerie du vivant), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Fondation Ophtalmologique Adolphe de Rothschild [Paris], CHU Saint-Antoine [AP-HP], Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Neurocentre Magendie-U862, Institut François Magendie, and Université de Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims (CHU Reims), [GIN] Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CentraleSupélec-Télécom Bretagne-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de Recherche en Informatique et en Automatique (Inria)-École normale supérieure - Rennes (ENS Rennes)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-CentraleSupélec-Télécom Bretagne-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École normale supérieure - Rennes (ENS Rennes)-Université de Bretagne Sud (UBS)-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), CHU Toulouse [Toulouse], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service de Neuroradiologie [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Inria de Paris, Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées - Strasbourg (INSA Strasbourg), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-École Nationale du Génie de l'Eau et de l'Environnement de Strasbourg (ENGEES)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Université de Lyon-Université de Lyon-CHU Grenoble-Hospices Civils de Lyon (HCL)-CHU Saint-Etienne-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Lorraine (INPL)-Université Nancy 2-Université Henri Poincaré - Nancy 1 (UHP)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Lorraine (INPL)-Université Nancy 2-Université Henri Poincaré - Nancy 1 (UHP), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Matériaux et nanosciences d'Alsace (FMNGE), Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Réseau nanophotonique et optique, Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Institut National de Recherche en Informatique et en Automatique (Inria)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche en Informatique et Systèmes Aléatoires (IRISA), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Bretagne Sud (UBS)-École normale supérieure - Rennes (ENS Rennes)-Télécom Bretagne-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
medicine.medical_specialty, Consensus, Multiple Sclerosis, Population, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Medical physics, education, Protocol (science), education.field_of_study, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Multiple sclerosis, Consensus development conferences as topic, Brain, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, 3. Good health, Workflow, Spinal Cord, Cohort, Physical therapy, Cohort studies, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), business, Working group, 030217 neurology & neurosurgery, Cohort study
Abstract

International audience; Multiple sclerosis (MS) is most generally considered as a severe disease with high physical and mental risks of disability. Since the end of the 1990s, several high cost long-term disease-modifying treatments provided some clinical efficiency. However, patient's follow-up was needed for the detection and the assessment of their side-effects. The “Observatoire français de la sclérose en plaques” (OFSEP) project aims to improve the clinical, biological and imaging systematic longitudinal follow-up of patients. It should increase the quality, efficiency and safety of patients’ care, with a unique opportunity of large scale, about 41,000 patients followed in 62 French centers using the European Database for Multiple Sclerosis (EDMUS) software. OFSEP is divided into three working groups (clinical, biological and imaging). The imaging working group defines standards for routine MRI follow-up in the whole cohort and contains three subgroups: acquisition, workflow, and data processing. A common and feasible brain and spinal cord acquisition protocol has been defined by the acquisition group, and accepted by the OFSEP steering and scientific committees. This protocol can be implemented in all French MRI centers. The major MRI manufacturers have agreed to provide the dedicated collection of sequences as an “OFSEP box” with every software upgrade or new MRI machine. The new OFSEP protocol will provide a unique opportunity to study a population-based collection of data from people with MS.

Published
2014

178. Effects of cognitive impairment on prosodic parameters of speech production planning in multiple sclerosis.

Author

De Looze, Céline, Moreau, Noémie, Renié, Laurent, Kelly, Finnian, Ghio, Alain, Rico, Audrey, Audoin, Bertrand, Viallet, François, Pelletier, Jean, and Petrone, Caterina

Subjects
PRODUCTION planning, FISHER discriminant analysis, MULTIPLE sclerosis, NEUROPSYCHOLOGICAL tests, ECOLOGICAL assessment, ARTICULATION (Speech)
Abstract

Cognitive impairment (CI) affects 40–65% of patients with multiple sclerosis (MS). CI can have a negative impact on a patient's everyday activities, such as engaging in conversations. Speech production planning ability is crucial for successful verbal interactions and thus for preserving social and occupational skills. This study investigates the effect of cognitive‐linguistic demand and CI on speech production planning in MS, as reflected in speech prosody. A secondary aim is to explore the clinical potential of prosodic features for the prediction of an individual's cognitive status in MS. A total of 45 subjects, that is 22 healthy controls (HC) and 23 patients in early stages of relapsing‐remitting MS, underwent neuropsychological tests probing specific cognitive processes involved in speech production planning. All subjects also performed a read speech task, in which they had to read isolated sentences manipulated as for phonological length. Results show that the speech of MS patients with CI is mainly affected at the temporal level (articulation and speech rate, pause duration). Regression analyses further indicate that rate measures are correlated with working memory scores. In addition, linear discriminant analysis shows the ROC AUC of identifying MS patients with CI is 0.70 (95% confidence interval: 0.68–0.73). Our findings indicate that prosodic planning is deficient in patients with MS‐CI and that the scope of planning depends on patients' cognitive abilities. We discuss how speech‐based approaches could be used as an ecological method for the assessment and monitoring of CI in MS. [ABSTRACT FROM AUTHOR]

Published
2019
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179. Metabolic counterparts of sodium accumulation in multiple sclerosis: A whole brain 23Na-MRI and fast 1H-MRSI study.

Author

Donadieu, Maxime, Le Fur, Yann, Maarouf, Adil, Gherib, Soraya, Ridley, Ben, Pini, Lauriane, Rapacchi, Stanislas, Confort-Gouny, Sylviane, Guye, Maxime, Schad, Lothar R., Maudsley, Andrew A., Pelletier, Jean, Audoin, Bertrand, Zaaraoui, Wafaa, and Ranjeva, Jean-Philippe

Subjects
BRAIN, MULTIPLE sclerosis, DEMYELINATION, MAGNETIC resonance imaging, NEURODEGENERATION, MYELIN sheath diseases
Abstract

Background: Increase of brain total sodium concentrations (TSC) is present in multiple sclerosis (MS), but its pathological involvement has not been assessed yet. Objective: To determine in vivo the metabolic counterpart of brain sodium accumulation. Materials/methods: Whole brain 23Na-MR imaging and 3D-1H-EPSI data were collected in 21 relapsing-remitting multiple sclerosis (RRMS) patients and 20 volunteers. Metabolites and sodium levels were extracted from several regions of grey matter (GM), normal-appearing white matter (NAWM) and white matter (WM) T2 lesions. Metabolic and ionic levels expressed as Z-scores have been averaged over the different compartments and used to explain sodium accumulations through stepwise regression models. Results: MS patients showed significant 23Na accumulations with lower choline and glutamate–glutamine (Glx) levels in GM; 23Na accumulations with lower N-acetyl aspartate (NAA), Glx levels and higher Myo-Inositol (m-Ins) in NAWM; and higher 23Na, m-Ins levels with lower NAA in WM T2 lesions. Regression models showed associations of TSC increase with reduced NAA in GM, NAWM and T2 lesions, as well as higher total-creatine, and smaller decrease of m-Ins in T2 lesions. GM Glx levels were associated with clinical scores. Conclusion: Increase of TSC in RRMS is mainly related to neuronal mitochondrial dysfunction while dysfunction of neuro-glial interactions within GM is linked to clinical scores. [ABSTRACT FROM AUTHOR]

Published
2019
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180. [Nosology and etiologies of acute longitudinally extensive transverse myelitis]

Author

Collongues, Nicolas, Papeix, C, Zephir, H, Audoin, Bertrand, Cotton, François, Durand-Dubief, Françoise, Vukusic, Sandra, Brassat, David, Laplaud, D, Marignier, R, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ben Dahan, David, and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI]Engineering Sciences [physics], [SPI] Engineering Sciences [physics], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014

181. Improvement of spasticity following intermittent theta burst stimulation in multiple sclerosis is associated with modulation of resting-state functional connectivity of the primary motor cortices

Author

Boutière, Clémence, primary, Rey, Caroline, additional, Zaaraoui, Wafaa, additional, Le Troter, Arnaud, additional, Rico, Audrey, additional, Crespy, Lydie, additional, Achard, Sophie, additional, Reuter, Françoise, additional, Pariollaud, Fanelly, additional, Wirsich, Jonathan, additional, Asquinazi, Patrick, additional, Confort-Gouny, Sylviane, additional, Soulier, Elisabeth, additional, Guye, Maxime, additional, Pelletier, Jean, additional, Ranjeva, Jean-Philippe, additional, and Audoin, Bertrand, additional

Published
2016
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182. Depletion of brain functional connectivity enhancement leads to disability progression in multiple sclerosis: A longitudinal resting-state fMRI study

Author

Faivre, Anthony, primary, Robinet, Emmanuelle, additional, Guye, Maxime, additional, Rousseau, Celia, additional, Maarouf, Adil, additional, Le Troter, Arnaud, additional, Zaaraoui, Wafaa, additional, Rico, Audrey, additional, Crespy, Lydie, additional, Soulier, Elisabeth, additional, Confort-Gouny, Sylviane, additional, Pelletier, Jean, additional, Achard, Sophie, additional, Ranjeva, Jean-Philippe, additional, and Audoin, Bertrand, additional

Published
2016
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186. Heterodyne ultrafast pump-probe experiments, towards acoustic imaging with 1 GHz to 100 GHz spectral range

Author

ABBAS, Allaoua, Guillet, Yannick, Audoin, Bertrand, Rampnoux, Jean-Michel, Dilhaire, Stefan, Carlier, Julien, Rigail, Pierre, Mottay, Eric, Laboratoire de Mécanique Physique (LMP), Centre National de la Recherche Scientifique (CNRS)-Université Sciences et Technologies - Bordeaux 1, Laboratoire Ondes et Matière d'Aquitaine (LOMA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), and Société Française d'Acoustique

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], jitter, heterodyne, pump-probe
Abstract

International audience; Usual femtosecond pump-probe experiments allow the generation and the detection of acoustic waves in the GHz-THz frequency range for investigation of matter properties at sub-micron scales. The main drawback of these experiments is their acquisition speed limitation due to the use of mechanical delay line. We present a pump-probe heterodyne setup which uses two mode-locked lasers (400 fs FHMW pulses at nearly 50 MHz repetition rate). A controlled frequency shift (100 Hz to 1 KHz) of their repetition rates synthesized by a Phase Locked Loop permits to generate the pump-probe delay and to discard the setup of any mechanical translation stage. An accurate control of the beating frequency is needed to achieve the temporal resolution required to detect high acoustic frequencies. Any fluctuation of this beating frequency induces an uncertainty on the pump-probe delay (jitter) and reduces the system bandwidth. We will expose the metrological method allowing the measurement of this jitter, which turns out to be smaller than 500 fs. This jitter value should permit the detection of waves over a large band spectrum, from few GHz to several hundreds of GHz with a 50 MHz spectral resolution. Experimental pump-probe measurements on different physical systems will highlight this feature.

Published
2012

187. Semi-analytical time-reversal imaging of a volume source in solids

Author

RAETZ, Samuel, Dehoux, Thomas, Audoin, Bertrand, Société Française d'Acoustique, Institut de Mécanique et d'Ingénierie de Bordeaux (I2M), Institut National de la Recherche Agronomique (INRA)-Université de Bordeaux (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), and System, HAL

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Laser-ultrasonics, Time reversal, Volume source imaging
Abstract

International audience; Based on the ability of acoustic waves to relive their past life, the time-reversal principle is of great interest for acoustic imaging. Many applications deal with focusing in soft materials. However, few applications concern solids because compressional- and shear-wave velocities are of the same order of magnitude, leading to mode conversion at interfaces. Moreover, only surface sources have been considered in solids. The purpose of this work is therefore twofold: imaging a volume acoustic source in a solid. The volume source is obtained by focusing a laser beam to a line with finite lateral dimension on the surface of a plate. The laser beam penetrates over a depth depending on the optical properties of the material. The normal displacements caused by acoustic waves generated by this volume source are measured at a surface of the plate. To analyze the optimal experimental configuration, normal displacements representing accurately the typical laser-ultrasonics data are computed. The time-reversal process, i.e., the playback of these normal displacements that leads to the reconstruction of the volume source, is experimentally complicated in laser-ultrasonics. A semi-analytical modeling is thus developed. Simultaneous imaging of the lateral dimension and penetration of the source is obtained and limitations are discussed.

Published
2012

188. Characterization of the contact between solids by laser-generated interface waves

Author

Valier-Brasier, Tony, Dehoux, Thomas, Audoin, Bertrand, System, HAL, and Société Française d'Acoustique

Subjects
Interface waves, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], Laser Ultrasonic
Abstract

Laser Ultrasonic techniques provide a powerful tool for the remote analysis of adhesion mechanisms at imperfect interfaces. However, the sensitivity of interface waves to the quality of interface is not very well known. In this context, the aim of this work is to study the influence of the contact between solids half-spaces on laser-generated interface waves. The mechanical boundary conditions at the interface between the solid half-spaces are described by a spring model, implying a discontinuity of the displacement fields across the interface and involving tangential and normal spring constants. To identify the relative amplitudes of the different types of interface waves (skimming, leaky Rayleigh and Stoneley waves), a semi-analytical time-model is derived. In addition, the dispersion curves for the interface waves are calculated to interpret the results of the time-model. The results demonstrate the influence of the boundary conditions on the attenuation of the leaky Rayleigh wave and on the existence of the Stoneley wave, which should prove to be a powerful tool for the inspection of contacting interfaces. Moreover, characteristic frequencies depending on normal and tangential springs constants are highlighted, suggesting a scaled behaviour of the interface waves.

Published
2012

189. Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome

Author

Maarouf, Adil, primary, Ferré, Jean-Christophe, additional, Zaaraoui, Wafaa, additional, Le Troter, Arnaud, additional, Bannier, Elise, additional, Berry, Isabelle, additional, Guye, Maxime, additional, Pierot, Laurent, additional, Barillot, Christian, additional, Pelletier, Jean, additional, Tourbah, Ayman, additional, Edan, Gilles, additional, Audoin, Bertrand, additional, and Ranjeva, Jean-Philippe, additional

Published
2015
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191. Efficacy of Rituximab in refractory Neuromyelitis Optica (P5.260)

Author

De Seze, Jerome, primary, Nicolas, Collongues, additional, Brassat, David, additional, Maillart, Elisabeth, additional, Labauge, Pierre, additional, Ouallet, Jean, additional, Brochet, Bruno, additional, Moreau, Thibault, additional, Bourre, Bertrand, additional, Audoin, Bertrand, additional, Vukusic, Sandra, additional, and Marignier, Romain, additional

Published
2015
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193. Results of a Phase 1b study to confirm safety and tolerability of olesoxime in multiple sclerosis patients (P7.282)

Author

Pelletier, Jean, primary, Ranjeva, Jean-Philippe, additional, Tourbah, Ayman, additional, Edan, Gilles, additional, Barillot, Christian, additional, Le La Mer, Sophie, additional, Audoin, Bertrand, additional, Rico Lamy, Audrey, additional, Crespy, Lydie, additional, Ridley, Ben, additional, Zaaraoui, Wafaa, additional, Confort-Gouny, Sylviane, additional, Guye, Maxime, additional, Maarouf, Adil, additional, Caucheteux, Nathalie, additional, Chaunu, Marie-Pierre, additional, Portefaix, Christophe, additional, Pierot, Laurent, additional, Commowick, Olivier, additional, Kerbrat, Anne, additional, Catanese, Laurence, additional, Cuvier, Valerie, additional, Veys, Julien, additional, Pruss, Rebecca, additional, and Hauke, Wilfried, additional

Published
2015
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196. Probing single-cell mechanics with picosecond ultrasonics

Author

Dehoux, Thomas, primary, Abi Ghanem, Maroun, additional, Zouani, Omar F., additional, Ducousso, Mathieu, additional, Chigarev, Nikolay, additional, Rossignol, Clément, additional, Tsapis, Nicolas, additional, Durrieu, Marie-Christine, additional, and Audoin, Bertrand, additional

Published
2015
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197. Adult-onset genetic leukoencephalopathies: A MRI pattern-based approach in a comprehensive study of 154 patients

Author

Ayrignac, Xavier, primary, Carra-Dalliere, Clarisse, additional, Menjot de Champfleur, Nicolas, additional, Denier, Christian, additional, Aubourg, Patrick, additional, Bellesme, Celine, additional, Castelnovo, Giovanni, additional, Pelletier, Jean, additional, Audoin, Bertrand, additional, Kaphan, Elsa, additional, de Seze, Jerome, additional, Collongues, Nicolas, additional, Blanc, Frederic, additional, Chanson, Jean-Baptiste, additional, Magnin, Eloi, additional, Berger, Eric, additional, Vukusic, Sandra, additional, Durand-Dubief, Francoise, additional, Camdessanche, Jean-Philippe, additional, Cohen, Mickael, additional, Lebrun-Frenay, Christine, additional, Brassat, David, additional, Clanet, Michel, additional, Vermersch, Patrick, additional, Zephir, Helene, additional, Outteryck, Olivier, additional, Wiertlewski, Sandrine, additional, Laplaud, David-Axel, additional, Ouallet, Jean-Christophe, additional, Brochet, Bruno, additional, Goizet, Cyril, additional, Debouverie, Marc, additional, Pittion, Sophie, additional, Edan, Gilles, additional, Deburghgraeve, Véronique, additional, Le Page, Emmanuelle, additional, Verny, Christophe, additional, Amati-Bonneau, Patrizia, additional, Bonneau, Dominique, additional, Hannequin, Didier, additional, Guyant-Maréchal, Lucie, additional, Derache, Nathalie, additional, Louis Defer, Gilles, additional, Moreau, Thibault, additional, Giroud, Maurice, additional, Guennoc, Anne Marie, additional, Clavelou, Pierre, additional, Taithe, Frédérique, additional, Mathis, Stephane, additional, Neau, Jean-Philippe, additional, Magy, Laurent, additional, Devoize, Jean Louis, additional, Bataillard, Marc, additional, Masliah-Planchon, Julien, additional, Dorboz, Imen, additional, Tournier-Lasserve, Elisabeth, additional, Levade, Thierry, additional, Boespflug Tanguy, Odile, additional, and Labauge, Pierre, additional

Published
2014
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198. Plasticity in MS : from functional imaging to rehabilitation

Author

Pelletier, Jean, Audoin, Bertrand, Reuter, Francoise, Ranjeva, Jean-Philippe, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Ben Dahan, David, and Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.OTHER]Engineering Sciences [physics]/Other, [SPI.OTHER] Engineering Sciences [physics]/Other, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

199. Cerebral plasticity and multiple sclerosis: data from functional imaging

Author

Pelletier, Jean, Audoin, Bertrand, Reuter, Francoise, Malikova, Irina, Rico, Audrey, Ali Cherif, A., Ranjeva, Jean-Philippe, Cozzone, Patrick J., Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), and Ben Dahan, David

Subjects
[SPI.OTHER]Engineering Sciences [physics]/Other, [SPI.OTHER] Engineering Sciences [physics]/Other, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

200. Onset and underpinnings of white matter atrophy at the very early stage of multiple sclerosis. A two-year longitudinal MRI/MRSI study of corpus callosum

Author

Audoin, Bertrand, Ibarrola, Danielle, Malikova, Irina, Soulier, Elisabeth, Confort-Gouny, Sylviane, Au Duong, My Van, Reuter, Francoise, Ali Cherif, A., Cozzone, Patrick, Ranjeva, Jean-Philippe, Centre de résonance magnétique biologique et médicale (CRMBM), Assistance Publique - Hôpitaux de Marseille (APHM)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), and Ben Dahan, David

Subjects
[SPI.OTHER]Engineering Sciences [physics]/Other, [SPI.OTHER] Engineering Sciences [physics]/Other
Published
2007

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