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Introduction: Sex and gender play roles in the pain experience, such that pain is more frequent in women. Explanations for this observation range from factors related to biological sex to those related to psychosocial gender., Objectives: To explore neuropathic pain characteristics in females with diabetes with and without established polyneuropathy., Methods: We compared the presence and intensity of pain in males and females in 2 separate cohorts of patients with type II diabetes, with and without established diabetic polyneuropathy. Cohort #1 was recruited prospectively, while cohort #2 was studied retrospectively., Results: Cohort #1 of 223 patients with diabetes with a relatively broad spectrum of nerve injury, showed more frequent pain in females (68% versus 53% in males), a higher frequency of additional neuropathic symptoms, and evidence of milder nerve injury. Cohort #2 of 128 patients with established diabetic polyneuropathy, showed a similar frequency of pain and additional neuropathic symptoms in both sexes. In both cohorts, females reported greater pain intensity (7.9-8.5 versus 6.8-6.9 in males, on visual analog scale)., Discussion: Though nerve injury and polyneuropathy are more common in males, females with diabetes report a higher frequency and intensity of pain despite milder polyneuropathy. Prospective epidemiological studies are required in order to confirm these findings in the community setting., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Aims: To determine the cross-sectional threshold at which hemoglobin A1c (HbA1c) is associated with polyneuropathy in healthy controls, and the values associated with the most pronounced decline in nerve function in patients with diabetes., Methods: We used data from a cross-sectional cohort study of healthy controls and type 2 diabetes patients assessed between November 2010 and May 2013. Healthy controls and patients with diabetes were compared at different HbA1c ranges: <5.5%, 5.5-5.9%, and 6-6.4% for controls, and 6.5-7.4% and >7.5% for patients with diabetes., Results: The total cohort included 53 controls and 164 patients with diabetes. Subclinical small nerve fiber impairments were observed in controls at HbA1c levels of 5.5-6%, compared with HbA1c <5.5%, for example: lower Laser Doppler flare imaging area of 2.8 ± 1.4 versus 3.9 ± 2 mm 2 . The most prominent decline in both small and large nerve fiber function was seen with less impaired glycemic control and shorter duration of diabetes, i.e. at HbA1c levels of 6.5-7.4%, compared with >7.5%., Conclusions: These findings underscore the importance of early treatment at the prediabetes and early diabetes stages to prevent nerve fiber decline that is likely irreversible., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Background: Hip fractures are the most severe complication of osteoporosis, yet patients who suffer hip fracture rarely receive adequate treatment., Aim: To assess diagnosis and treatment of osteoporosis in patients with hip fracture., Patients and Methods: A retrospective study in 203 patients admitted for hip fracture surgery at two medical institutions in Santiago, Chile. Clinical data from 101 patients from the Hospital Clínico Pontificia Universidad Católica de Chile (a university tertiary care hospital, HCPUC) and 102 patients from Hospital de Urgencia de la Asistencia Pública (a public emergency hospital, HUAP) were reviewed. We also evaluated incidence of new fractures, further treatment of osteoporosis and functionality, by means of a telephonic survey of 48% of patients (n = 99) 12.3 +/- 5.3 months after hip fracture in HCPUC and 16.5 +/- 3.0 months for HUAP., Results: A previous diagnosis of osteoporosis was present in 2.9% and 1% of cases, and treatment prior to fracture in 3.9% and 0% of cases from HCPUC and HUAP, respectively. None of the patients in HUAP were diagnosed with osteoporosis during hospital stay or given treatment for this condition at discharge, in comparison to 0.9% (n = 1) and 2% (n = 2), respectively, in HCPUC. Seven and six percent of cases presented prior hip fractures. Telephonic follow up of patients revealed that 75.6% persisted without treatment for osteoporosis. At follow up, 2.9% and 3% of patients in HCPUC and HUAP had presented new hip fractures. At the time of survey 30.9% and 34% of patients, respectively, were considered invalid., Conclusions: Missed diagnosis and failure to treat osteoporosis occurred in over 90% of patients admitted for hip fracture, regardless of the different complexities in the hospitals of admission. The data suggest that lack of medical action on these issues may play a role in failure to prevent new hip fractures.