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1,448 results on '"Baumgärtner, W."'

164. Characterization of Different Monoclonal and Polyclonal Antibodies for Immunohistological Detection of Rift Valley Fever Virus Antigens

Author

Michaely, L.M., primary, Gregor, K.M., additional, Keller, M., additional, Rissmann, M., additional, König, R., additional, Gutjahr, B., additional, Dornbusch, S., additional, Schön, K., additional, Puff, C., additional, Ulrich, R., additional, Becker, S., additional, Groschup, M.H., additional, Baumgärtner, W., additional, Eiden, M., additional, and Spitzbarth, I., additional

Published
2020
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168. Virus-triggered spinal cord demyelination is followed by a peripheral neuropathy resembling features of Guillain-Barré Syndrome

Author

Leitzen, E., Raddatz, B., Jin, W., Goebbels, S., Nave, K., Baumgärtner, W., and Hansmann, F.

Subjects
viruses, lcsh:R, lcsh:Medicine, Peripheral Nervous System Diseases, Guillain-Barre Syndrome, Immunohistochemistry, Article, Disease Models, Animal, Mice, Spinal Cord, Theilovirus, Virus Diseases, Animals, lcsh:Q, Disease Susceptibility, lcsh:Science, Biomarkers, Demyelinating Diseases, Poliomyelitis
Abstract

Theiler’s murine encephalomyelitis virus (TMEV)-induces a demyelinating disease in the spinal cord (SC) of susceptible but not in resistant (B6) mouse strains. The aim of the present study was to induce SC demyelination and a peripheral neuropathy in resistant mice by switching the infection site from cerebrum to SC. B6 mice were intraspinally inoculated with TMEV. Infected mice showed clinical signs starting at 7 days post infection (dpi). Histopathology revealed a mononuclear myelitis, centred on the injection site at 3 dpi with subsequent antero- and retrograde spread, accompanied by demyelination and axonal damage within the SC. Virus protein was detected in the SC at all time points. SC inflammation decreased until the end of the investigation period (28 dpi). Concurrent with the amelioration of SC inflammation, the emergence of a peripheral neuropathy, characterized by axonal damage, demyelination and macrophage infiltration, contributing to persistent clinical sings, was observed. Intraspinal TMEV infection of resistant mice induced inflammation, demyelination and delayed viral clearance in the spinal cord and more interestingly, subsequent, virus-triggered inflammation and degeneration within the PN associated with dramatic and progressive clinical signs. The lesions observed in the PN resemble important features of Guillain-Barré syndrome, especially of acute motor/motor-sensory axonal forms.

Published
2018

172. Feline Parvovirusinfektion beim Waschbär

Author

Junginger, J, additional, Eikelberg, D, additional, Jesse, ST, additional, Ludlow, M, additional, Hansmann, F, additional, Pfankuche, VM, additional, Störk, T, additional, Puff, C, additional, Osterhaus, A, additional, and Baumgärtner, W, additional

Published
2019
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177. Charakterisierung verschiedener mono- und polyklonaler Antikörper zum immunhistologischen Nachweis des Rifttalfiebervirus

Author

Michaely, LM, additional, Gregor, KM, additional, Keller, M, additional, Rissmann, M, additional, König, R, additional, Gutjahr, B, additional, Dornbusch, S, additional, Schön, K, additional, Puff, C, additional, Ulrich, R, additional, Becker, S, additional, Groschup, MH, additional, Baumgärtner, W, additional, Eiden, M, additional, and Spitzbarth, I, additional

Published
2019
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187. Vergleichende Untersuchungen verschiedener In-situ-Hybridisierungs-Methoden zur Virusdetektion

Author

Pfankuche, VM, additional, Hahn, K, additional, Bodewes, R, additional, Hansmann, F, additional, Habierski, A, additional, Haverkamp, AK, additional, Pfaender, S, additional, Walter, S, additional, Baechlein, C, additional, Postel, A, additional, Steinmann, E, additional, Becher, P, additional, Osterhaus, A, additional, Baumgärtner, W, additional, and Puff, C, additional

Published
2019
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189. Usutu-Virus-Infektion bei Vögeln in Deutschland: Läsionen und Virusverteilung

Author

Haverkamp, AK, additional, Peters, M, additional, Fast, C, additional, Ziegler, U, additional, Gregor, K, additional, Wiesner, L, additional, Steffen, I, additional, Jesse, ST, additional, Ludlow, M, additional, Osterhaus, A, additional, Beineke, A, additional, Hansmann, F, additional, Wohlsein, P, additional, and Baumgärtner, W, additional

Published
2019
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194. Histologische Befunde bei equiner Hepacivirusinfektion

Author

Puff, C, additional, Pfankuche, VM, additional, Tegtmeyer, B, additional, Echelmeyer, J, additional, Todt, D, additional, Fischer, N, additional, Feige, K, additional, Steinmann, E, additional, Cavalleri, JMV, additional, and Baumgärtner, W, additional

Published
2019
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197. Germ Line Deletion Reveals a Nonessential Role of Atypical Mitogen-Activated Protein Kinase 6/Extracellular Signal-Regulated Kinase 3

Author

Ronkina, N., primary, Schuster-Gossler, K., additional, Hansmann, F., additional, Kunze-Schumacher, H., additional, Sandrock, I., additional, Yakovleva, T., additional, Lafera, J., additional, Baumgärtner, W., additional, Krueger, A., additional, Prinz, I., additional, Gossler, A., additional, Kotlyarov, A., additional, and Gaestel, M., additional

Published
2019
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