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High impact polystyrene sheets (HIPS) of 1.5 mm and 2.5 mm thicknesses were thermoformed on moulds of different parameters at sheet heating temperatures of 130℃ and 140℃. Formability studies indicated no difference in wall thickness distribution at different sheet temperatures. Due to non-uniform stretching of the sheet, wall thickness distribution along the slant length was found to have three regions. In the regions near the mould corner and clamp point, wall thickness was found to decrease with increase in distance from the corner, in these zones. The decrease near the corner was much greater and sharper than that near the clamp point. The decrease in both regions was found to increase at higher depths of draw and decrease at higher draft angles. In the intermediate portion of the slant length, no significant variation in wall thickness was observed. [ABSTRACT FROM AUTHOR]

High performance radar transparent materials (RTMs) are important materials for the fabrication of radomes, nosecones, etc. of high velocity aerospace vehicles. RTMs with good mechanical performance and temperature capability are required for such applications. Toward this, fabric reinforced nano-reinforced matrix composites (FRNCs), using reinforcing E-glass fabric in Cloisite 30B reinforced polyetherimide (PEI) nanocomposite matrix (GNRPEI), was prepared. The properties of GNRPEI were evaluated and compared with E-glass fabric reinforced PEI composites (GRPEI) with special reference to their radar transparent character for aerospace applications. Tensile and flexural properties along with interlaminar shear strength of GRPEI were observed to be lower than those of GNRPEI. Thermal behavior of both the composites was similar in differential scanning calorimetry and thermal gravimetric analysis. But, in dynamic mechanical analysis, an increase in storage modulus and decrease in loss tangent were observed in GNRPEI compared to GRPEI. The values of dielectric constant and loss tangent of GNRPEI were lesser than those of GRPEI, but no significant difference was observed in the values of transmission and reflection losses for both the composites at 8-12 GHz frequency. FRNCs, based on organoclay reinforced PEI matrix, hold good promise as high performance RTMs. Copyright © 2010 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Pelvic prolapse affects one woman in three of all ages combined and is quite common for more than 60% of patients over 60 years of age. The treatment of this pathological problem is one of the biggest challenges to the gynaecologist today. The rate of surgical intervention failure is quite significant. The recurrence of prolapse could be related to inadequate surgical technique or the pathology or/and biomechanical deficiency of the soft tissues. The modelling and simulation of the behaviour of the pelvic cavity could be a major tool for specific evaluation of pelvic status. A first stage of this model is being developed and reported. The computer-aided design model of the organs of the pelvic floor is created using magnetic resonance image data and the ligament boundary conditions are defined. A multi-organ geometric model is thus created and studied. [ABSTRACT FROM AUTHOR]

In the present research, glass and basalt fiber-reinforced polypropylene composites' behaviour in quasi-static and dynamic conditions is studied. Composites were fabricated by vacuum assisted Compression molding method. Composites failure under quasi-static tension and compressive conditions was studied along with its failure behaviour under low-velocity impact and super-sonic shock loading under dynamic conditions. The study results showed that basalt fiber-reinforced polypropylene (Basalt/PP) composite's tensile and compressive strength is higher than glass fiber-reinforced polypropylene (Glass/PP). The Basalt/PP showed no penetration against low velocity impact (LVI) with negligible deformations till 50 J. However, the Glass/PP perforated at 50 J with various failure patterns occurring at back side. The fiber-matrix interface adhesion plays an important role in super-sonic shock loading by absorbing shock wave energy due to ductile nature of polypropylene and the two composites absorbed energy via matrix and fibers failure, no brittle failure of laminates occurred under shock loading. [ABSTRACT FROM AUTHOR]

All bioresorbable polymeric implants are radiolucent, making them undetectable under the X-rays. Therefore, to improve their X-ray visibility, the high effective atomic number (Zeff) material such as Pt, Au, Ta, Ba, or its alloy are attached to the body of the bioresorbable implant. However, during the in vivo degradation, these bio-inert heavy metals can either detach or leach out from the lesion site and accumulate into the vital organ, leading to severe health complications. Thus, as a strategy, the novel biodegradable and radiopaque Mg alloy was produced to impart X-ray visibility in the biopolymer. Here, the Mg was alloyed with the optimized ratio of heavy metals, i.e., Zn and Y. The radiopaque Mg alloy was characterized and powdered to the size of 25–20 µm. Further, it was blended with radiolucent Poly-L-lactic acid (PLLA) and polycaprolactone (PCL) polymer. The Bi-axially expanded (BAE) tubes of PLLA/PCL and PLLA/PCL/Mg alloy (5% wt.) were extruded for fabricating cardiovascular stents. The BAE tube comparison studies were performed for thermal stability, wettability, surface roughness, and mechanical properties. The potential of 5% Mg alloy in the polymeric matrix was evaluated as a nucleating, reinforcing, and radiopaque agent. In vitro accelerated degradation study was performed in the physiological fluid to evaluate the pH variation and decomposition rate. Finally, in vitro biocompatibility was assessed by evaluating the behavior of L929 fibroblast cells, followed by the blood biocompatibility test on the blends. [ABSTRACT FROM AUTHOR]

TITLE: A PROSPECTIVE STUDY OF ASSESSMENT OF BREAST ANTHROPOMETRY IN INDIAN BREAST CANCER PATIENTS INTRODUCTION: India has one of the youngest populations but there is a troubling trend of increasing breast cancer incidence. With increasing affluence, awareness and social demands, the demand for breast conservation surgery and standard of care has increased. Surgical options are guided by tumor, breast volume and patient factors. There is a difference between our population and the much studied west. In the current study, we tried to explore this hypothesis and tried to establish a baseline measurement of various anthropometric parameters of breast in Indian breast cancer patients. Further, we tried to categorise these parameters and attempted a correlation with breast conservation surgery, tumor and breast volume. MATERIALS AND METHODS: The study was done prospectively in 102 patients between January to October 2016. Anthropometric measurements of breast, nipple areola complex, ptosis and mammographic breast density of the normal breast were recorded. Breast volume was measured with a geometric method devised by Qiao et al. The measurements were done with the help of measuring tape, calipers and rulers and were categorized using quartiles. Tumor size and the surgery performed in these patients was also recorded. 70 patients were suitable for correlation of breast volume and tumor size. RESULTS: Mean breast volume in the study was 303 ml (93.25 - 1345 ml). Breast volume was divided into category I (<170ml), category II (170 - 360 ml) and Category III (>360 ml). Mean areola diameter, nipple diameter, nipple projection were 4.53 cm (2.3 - 8 cm), 0.99 cm (0.6 - 1.5cm) and 0.77 cm (0.3 - 1.5cm) respectively. 51 patients had grade 3 ptosis. Most common mammographic breast density is ACR II. BCS rate in category I was 17.64 percent while categories II and III had a BCS rates of 37.14 and 38.88 percent respectively. CONCLUSION: Breast measurements of Indian women are different from their western counterparts. Ptosis is seen more often. Geometric methods can be used to calculate breast volume and can help predict breast conservation rates and in patient referral. There is a paucity of literature on breast anthropometry in Indian breast cancer patients and this is one of the first studies to address it and its implications on surgery. [ABSTRACT FROM AUTHOR]

A correction to the article "Ultrasound-induced nucleation in microcellular polymers," by Abhishek Gandhi et al., published online on October 30, 2015 is presented.

Compressive behaviour of open and closed cell polyurethane foam samples under large deformation is studied using micro‐Computed Tomography (micro‐CT), Digital Volume Correlation (DVC) technique and micro‐Finite Element (micro‐FE) modelling. The micro‐CT images of the foam samples at different compression strains are used to determine anisotropy in the foams, to obtain qualitative information on deformation mechanisms, to quantify the deformation and strains using a local DVC approach and to generate images for micro‐FE modelling of the foam samples. Micro‐FE modelling predicts the deformation using an elastoplastic material model coupled with continuum damage mechanics. Two different types of boundary conditions, experimentally derived (ExBC) and interpolated from DVC (IPBC), were implemented to evaluate the displacements in the micro‐FE models. A reduced integration scheme in micro‐FE analysis resulted in high artificial energy and was discarded in favour of full integration. The displacement predicted by IPBC matched with DVC displacement contours for closed cell foam. The ExBC‐predicted axial displacement (W) showed a better agreement with DVC than transverse displacements (U, V) contours. However, a significant statistical comparison (R2 > 0.70) of all displacements was obtained for both IPBC and ExBC. For open cell foam, both boundary conditions predicted a significant difference in the displacement contours with respect to DVC measurements. Still, the axial displacements of ExBC and IPBC showed a better statistical significance (R2 > 0.70). [ABSTRACT FROM AUTHOR]

In this study, the influence of hybridization on the compression response of thermoplastic matrix-based composites under high strain rate loading was investigated. The intra-ply and inter-ply hybrid composites were manufactured with Kevlar/Basalt yarns as the reinforcements with Polypropylene as a matrix. Cylindrical composite specimens were laser cut from the flat compression moulded laminates. The composite specimens were loaded under high strain rate using split-Hopkinson pressure bar setup at strain rates ranging from 2815/s to 5481/s. The study revealed differences in the rate-dependent growth of peak stress, peak strain and toughness with the strain rate. Intra-ply hybrid composites with alternate weaving of Kevlar and basalt yarns exhibited highest peak stress as compared to the Inter-ply hybrid composites (alternate layers of Kevlar and basalt fabrics) and another intra-ply composite containing Kevlar in the warp and basalt in the weft direction. Whereas in inter-ply hybrid composite, with Kevlar as the loading face attained higher stress, while composite with Basalt as the loading face attained higher strain. SEM micrographs revealed that Kevlar on the loading face can bear the impact with lesser delamination as compared to the Basalt on the loading face. Damage studies revealed that Kevlar fiber surface loading results in higher stress as compared to basalt (brittle) surface loading with lower overall damage. • The influence of hybization on the high strain rate resposne of thermoplastic composites. • Intra-ply hybridization excels over inter-ply hybridization. • Placement and direction of yarns is crucial in intra-ply hybridization. • Higher areal density fabrics are replacable with hybrid fabrics of lower areal density. [ABSTRACT FROM AUTHOR]

The demand of high-speed wireless communication has increased, which need the data rate to be in the order of Terabyte per second (Tbps) in the near future. Terahertz (THz) band communication is a key wireless communication technology to satisfy this future demand. This would also reduce the spectrum scarcity and capacity limitation of current wireless systems. Microfabricated Folded Waveguide TWTs are the potential compact sources of wide band and high-power terahertz radiation. This study primarily focuses on machining technology for THz waveguide components requiring ultra-high precision micromachining. Rectangular waveguides, especially Folded Waveguides (FW), are even more difficult to manufacture using conventional machining techniques due to their small size and very tight tolerances. The criticalities in micromachining of FW for 0.22 THz have been addressed in this article. Half hard free cutting Brass IS 319-H2 was used as a work material due to its electrical and mechanical properties. Waveguide size of 0.852 × 0.12 mm was machined within ± 3–5 μm linear tolerances, surface roughness in the order of 45 nm Ra, and flatness less than half of wavelength (< λ/2). The split top and bottom blocks of the folded waveguide were aligned by dowel pins which matched within a tolerance of ± 5 μm. The perpendicularity and parallelism were maintained within 5 μm tolerance. This work explored and established the application of micromilling as reasonably suitable for the THz waveguides followed by ultrasonic cleaning as deburring. It also investigated the measured folded waveguide losses which were close to simulated values. [ABSTRACT FROM AUTHOR]

In the present work, dynamic compression response of polypropylene (PP) based composites reinforced with Kevlar/Basalt fabrics was investigated. Two homogeneous fabrics with Kevlar (K3D) and Basalt (B3D) yarns and one hybrid (H3D) fabric with a combination of Kevlar/Basalt yarns were produced. The architecture of the fabrics was three-dimensional angle-interlock (3D-A). Three different composite laminates were manufactured using vacuum-assisted compression molding technique. The high strain rate compression loading was applied using a Split-Hopkinson Pressure Bar (SHPB) set-up at a strain rate regime of 3633–5235/s. The results indicated that the dynamic compression properties of thermoplastic 3D-A composites are strain rate sensitive. In all the composites, the peak stress, toughness and modulus were increased with strain rate. However, the strain at peak stress of Basalt reinforced composites (B3D, H3D) decreased approximately by 25%, while for K3D specimens it increased approximately by 15%. The K3D composites had a higher strain rate as compared to the B3D and H3D composites. In the case of K3D composite, except strain at peak stress, remaining dynamic properties were lower than the B3D composite, however, hybridization increased these properties. The failure mechanisms of 3D-A composites were characterized through macroscopic and scanning electron microscopy (SEM). [ABSTRACT FROM AUTHOR]

The present study compared the tensile and low velocity impact (LVI) response of Kevlar/basalt fabrics. Homogeneous and hybrid fabrics with structures of two dimensional plain woven (2D-P) and three dimensional angle-interlock (3D-A) were woven with Kevlar and basalt yarns. Interlacing of brittle basalt yarns with high-ductility/high-toughness Kevlar yarns enhanced the tensile strength of 2D-P fabrics by 5.39–50.29% and 3D-A fabrics by 14.80%. Similarly hybridization enhanced the energy absorption of 2D-P fabrics by 8.58–37.71% and 3D-A fabrics by 13.45–20.14%. Change in the architecture from 2D-P to 3D-A also enhanced the tensile and impact resistance of fabrics. Different failure modes induced due to tensile and LVI loads were identified. [ABSTRACT FROM AUTHOR]

The dynamic behaviour of the High Strength Low Alloy (HSLA) Steel before and after heat treatment was examined experimentally by performing quasi-static and high strain rate testing at room temperature and cryogenic temperatures. The high strain rate tensile testing of the material was performed on a Split Hopkinson Tensile Bar (SHTB) setup. A customized liquid nitrogen chamber equipped with UTM and SHTB was used to perform the cryogenic temperature testing. The stress–strain response of the material under different loading conditions was recorded and a modified Johnson–Cook material model was derived. It was observed that the flow stress of the material increased when tested at a high strain rate and it further increased at a cryogenic high strain rate loading environment. The microstructure of the material before and after heat treatment was also observed to identify the dominant phase change in microstructure contributing towards improvement in strength after heat treatment. The failure analysis of each category of the samples was examined under the Scanning Electron Microscope (SEM) after the testing. The formation of small and deep dimples for as-received samples and bigger and shallow dimples for heat-treated samples distinguished the type of failure between the quasi-static, high strain rate and cryogenic high strain rate material testing. • High Strength Low Alloy Steel (HSLA) were characterized at Quasi-Static and high strain rate tensile testing at room temperature and cryogenic temperature in both annealed and post heat treated conditions. • The customized Split Hopkinson Tensile Bar equipped with liquid nitrogen chamber and on-board temperature measurement system was developed to perform high strain rate cryogenic testing of HSLA steel. • The fractured surface of annealed and post heat treated samples were examined to understand the underlying effect contributing towards improvement in mechanical properties of the HSLA steel. • The modified Johnson–Cook material model parameters were derived based on the experimental results. The numerical simulations were performed to verify the developed constituent model. [ABSTRACT FROM AUTHOR]

Kevlar ® fabric reinforced plastics (KFRPs) are specialized composites with multiple layers of fabrics (∼ranging from 20 to 50 layers) designed for high impact applications. In this work, Kevlar-129 fiber was reinforced with polyetherimide (PEI) and polypropylene (PP) to obtain two groups of laminates in three configurations i.e. 16, 24 and 30 layers. Holes of diameter 11.6 mm were profile cut using fiber laser machining system operating at 1070 nm wavelength. Effects of polymeric matrix on the failure of the Kevlar – polyetherimide (K-PEI) and Kevlar – polypropylene (K-PP) laminates were characterized by studying the following: (i) threshold laser power required to make the holes (ii) surface morphology using scanning electron microscopy (iii) damage zone along the laser cut path using scanning acoustic microscopy and optical microscopy. K-PEI laminates underwent material separation at much lesser line energy (ratio of laser power to velocity) than K-PP laminates during laser machining. Scanning electron microscopy (SEM) was used to further analyze the laser cut surfaces. A prominent observation on the laser-irradiated surface was: less recast/resolidified polymer covered the Kevlar fabric in K-PEI as compared to a thicker polymeric layer in K-PP. Heat affected zone and damage factors were evaluated using scanning acoustic microscopy (SAM). Surface roughness and kerf width were also analyzed to understand the effect of laser machining of Kevlar laminates. [ABSTRACT FROM AUTHOR]

The present work reported the mechanical characterization of novel polypropylene (PP) composites reinforced with three-dimensional angle-interlock (3D-A) Kevlar/basalt fabrics. Two homogeneous fabrics with Kevlar (K3D) and basalt yarns (B3D), and a hybrid fabric (H3D) with a combination of both Kevlar and basalt yarns were produced. Three types of two layer 3D-A composites were manufactured using vacuum-assisted compression molding method. Static tensile and in-plane compression tests were carried out on the manufactured composites. The mechanical behavior of the three 3D-A composites was compared in terms of stress-strain response, elastic modulus, strength and failure strain. Influence of hybridization on the mechanical behavior of the 3D-A composites was also studied. Significant improvement in the tensile behavior of 3D-A homogeneous composites was observed due to hybridization. Meanwhile, there was no considerable improvement in in-plane compression behavior. The damage patterns for in-plane compression loading were examined through scanning electron microscopy (SEM) to explore the possible damage patterns such as matrix cracking, fiber failure, delamination and deformation. Numerical simulations were carried out using ABAQUS/Standard, by implementing a user-defined material subroutine (VUMAT) based on the Chang-Chang linear orthotropic damage model. Good agreement between experimental and numerical simulations was achieved in terms of damage patterns. [ABSTRACT FROM AUTHOR]

Experimental and numerical investigations are carried out to determine the low velocity impact (LVI) response of three different polypropylene (PP) composites. Three dimensional (3D) angle-interlock fabrics with Kevlar, basalt and a hybrid combination of both are produced. 3D composites are manufactured with these three fabrics using vacuum-assisted compression molding process with PP resin. LVI tests are conducted using a drop-weight impact equipment at the energy level of 240 J. The LVI response of the three 3D-PP composites is compared in terms of peak force, energy absorption and damage modes. The experimental results indicate that the basalt 3D composites showed 6.62–13.73% higher peak force and H3D composites absorbed 7.67-48.49% more energy than the remaining composites. Results indicate that there is a considerable enhancement in the energy absorbing capability of hybrid composites as compared to Kevlar/PP and basalt/PP composites. Numerical simulations are carried out using the commercial finite element (FE) code ABAQUS/Explicit. A user-defined material subroutine (VUMAT) based on Chang-Chang linear orthotropic damage model, is implemented into the FE code. Good agreement between experimental and numerical simulations is achieved in terms of impact response characteristics. [ABSTRACT FROM AUTHOR]

In this study, experimental investigations on Kevlar fiber reinforced polypropylene (PP) woven composites under high strain rate compression loading are discussed. Kevlar/PP composite laminates with 8 and 24 layers are fabricated using vacuum assisted compression molding technique. Maleic anhydride grafted-PP (MAg-PP) is added to PP to improve the interfacial property between Kevlar fiber and PP resin. The through-thickness properties at high strain rates from 1370 to 6066 s −1 are obtained using split Hopkinson pressure bar (SHPB) setup. The behavior of PP resin is found to be different than the commonly used thermoset resins, such as epoxy. Dynamic stress–strain relations are drawn to reveal the mechanical properties at high strain rates and these relations appear to be rate sensitive. As a result, the peak stress increased by three times, toughness increased by almost ten times and strain at peak stress increased by as much as two times with an increase in the strain rate. The final failure of the specimens is examined by scanning electron microscopy (SEM) to explore the possible failure mechanisms such as, delamination, fiber failure and shear fracture. [ABSTRACT FROM AUTHOR]

• Vacuum compression moulded Basalt-Polyeteherimide (PEI) composites manufacturing. • Optimization of Basalt-PEI composite manufacturing moulding parameters. • Basalt-PEI composite under quasi-static and dynamic high strain rate loading. • Elastic recovery of Basalt-PEI composite can help in reflecting the blast wave. High temperature blast and ballistic resistant light weight fibre reinforced plastic composites are very much in demand. Accordingly, the present investigation is focused on the quasi-static and high strain rate behaviour of Basalt/Polyetherimide (PEI) composite. Nine different types of composite samples were fabricated by compression moulding. The moulding pressures and temperatures were varied in the range of 15–25 bars and 325 °C−375 °C, respectively. Quasi-static testing was done at the rate of 3 mm/min to establish the optimum moulding parameters. High strain rate compression tests in the strain rate range of 900/s−3200/s were performed on the optimum moulded composite specimens. High strain rate testing revealed that 40 layered Basalt/PEI composite moulded at 25 bar pressure and 350 °C attained highest stress of 932 MPa whereas, the same was found to attain 446 MPa under quasi-static loading conditons. Thus, establishing the rate depedency of Basalt/PEI composite. Damage studies revealed that Basalt/PEI undergoes brittle damage, typically resulting in shear plane angle of 42°−45°. SEM micrographs revealed brittle fibre failure and matrix free fibre bundles, indicating the importance of process parameter optimiation. [ABSTRACT FROM AUTHOR]

The present study deals with the quasi-static and high strain rate characterization of Kevlar-129 based thermoplastic composites. Two different thermoplastic matrices, namely, Polypropylene (PP) and Polyetherimide (PEI) were used to manufacture composite laminates. Quasi-static compression tests were performed at strain rates of 0.041 s−1 and 0.045 s−1. High strain rate tests were performed using a split Hopkinson pressure bar apparatus within the strain rates ranging from 2548 s−1 to 4379 s−1. Stress-strain relations reveals the rate-sensitive behaviour of composites. Kevlar/PP (K-PP) showed higher peak stress under quasi-static loading as compared to the high strain rate test. Comparable peak stresses were revealed under quasi-static and high strain rate loading for Kevlar/PEI (K-PEI) composite. Also, high strain rate compression properties such as peak stress, peak strain and toughness of K-PP were 25%, 27% and 6% higher than that of the K-PEI composite. The failure mechanisms of both the composites were characterized through macroscopic and scanning electron microscopy. K-PP failed majorly due to matrix crush and fibre failure while K-PEI failed due to shear cracking. Damage study reveals that a single fibre based composite system can be tailored to act as an energy-absorbing or dissipating material system by varying the thermoplastic matrix materials. • Static and dynamic compressive properties of Kevlar reinforced high-performance polymers. • Kevlar/Polypropylene outperforms over Kevlar/Polyetherimide under both the quasi-static and high strain rate loads. • The quasi-static strength of Kevlar/Polypropylene is 25% higher than its high strain rate strength. • Polypropylene matrix results in ductile failure, while the Polyetherimide matrix results in brittle failure. [ABSTRACT FROM AUTHOR]

Modification of Polylactic acid (PLA), a biopolymer, is a strategy still to be fully explored for the next generation of bioresorbable vascular stent (BVS) biomaterials. With this focus, inclusions upto 5% of Polycaprolactone (PCL) and Magnesium in PLA were tested in the rat subcutaneous model and their cellular and tissue interactions characterized, specifically with respect to inflammatory response, angiogenesis and capsularization. The cytokines IL6, TNF Alpha and IL-1Beta were estimated in the peri-implant tissue, all of which showed a non-significant difference between the non-implanted animals and those containing PLA by 8 weeks, speaking to the benign nature of PLA as an implant biomaterial. Both modified materials, had increased macrophage counts and cytokine levels, except IL6 at 8 weeks. Vascularization only at 8 weeks in PLA PCL containing tissue was significantly higher than pure PLA, which may be more carefully controlled along with the material hydrophobicity for possible efforts towards therapeutic angiogenesis. Capsule thickness, measured by staining with both Hematoxylin & Eosin and Masson's Trichome did not show any differences between materials, including PLA. [ABSTRACT FROM AUTHOR]

Quasi-static tensile test of UHMWPE fiber-reinforced composite laminate is challenging to perform due to low interlaminar shear strength and low coefficient of friction. Tensile tests proposed in the literature were conducted and limitations associated with each method led to the evolution of a new method. Tensile test of single-ply was realized as the best representative of tensile strength of a composite than tensile test of UHMWPE laminate. A fixture was developed for single-ply tests which increased friction and provided the mechanical constraint to slipping. The fixture is easy to fabricate and has provided repeatable results for eight grades of UHMWPE fiber-based (0/90) fabrics. Reported tensile strengths are in quite high range of 900–1500 MPa. • Ballistic composites are quite different from structural composites. • Tensile strength difficult to determine with standard methods. • All available methods tested for efficacy. • A new method is suggested for efficient testing. • Properties of wight commercial grades determined by suggested method. [ABSTRACT FROM AUTHOR]

Tracheoesophageal voice prostheses (TEPs) are soft polymeric devices used to restore the voices of patients who have undergone total laryngectomy (TL). TEPs are implanted on the tracheoesophageal wall and come in direct contact with food, fluid and air. The environment of an implant is a budding ground for growth of microbes, leading to biofilm formation on the TEP surfaces. Biofilm formation is the leading cause of TEP failure because the biofilm affects its functioning by clogging the air passage over several weeks to a few months. Short useful lifespan of TEPs is a concern for patients undergoing total laryngectomy. To increase the useful lifespan of TEPs, it is imperative to prevent biofilm formation. This problem is addressed in the present study by developing a cationic crosslinked antimicrobial coating that prevents biofilm formation through contact killing. An acrylate-based tetracopolymer poly(methyl methacrylate [MMA]- co-n butyl acrylate [BA]- co -dimethylaminoethyl methacrylate [DMAEMA]- co -2 hydroxyethyl methacrylate [HEMA]) was synthesized by free radical polymerization and was crosslinked by hexamethylene diisocyanate (THDI) trimer through urethane linkages. The crosslinked tetracopolymer coatings were subjected to quaternary ammonium formation through N -alkylation with iodooctane. Different variants of coatings were synthesized and the tetracopolymer with 22.5% MMA, 22.5% BA, 20% HEMA and 35% DMAEMA showed desirable results. The developed coatings were characterized and tested for safety as well as mechanical and antimicrobial efficacy. The final results showed that the developed coatings exhibited good cytocompatibility, haemocompatibility, mechanical properties and antimicrobial properties for 180 days against E. coli , S. aureus and C. albicans.

A state of hypoxia (lack of oxygen) persists in the initial and later phases of healing in cardiovascular diseases, which can alter the tissue's repair or regeneration, ultimately affecting the structure and functionality of the related organ. Consequently, this results in a cascade of events, leading to metabolic stress and the production of reactive oxygen species (ROS) and autophagy. This unwanted situation not only limits the oxygen supply to the needy tissues but also creates an inflammatory state, limiting the exchange of nutrients and other supplements. Consequently, biomaterials have gained considerable attention to alleviate hypoxia and oxidative stress in cardiovascular diseases. Numerous oxygen releasing and antioxidant biomaterials have been developed and proven to alleviate hypoxia and oxidative stress. This review article summarizes the mechanisms involved in cardiovascular pathologies due to hypoxia and oxidative stress, as well as the treatment modalities currently in practice. The applications, benefits and possible shortcomings of these approaches have been discussed. Additionally, the review explores the role of novel biomaterials in combating the limitations of existing approaches, primarily focusing on the development of oxygen-releasing and antioxidant biomaterials for cardiac repair and regeneration. It also directs attention to various other potential applications with critical insights for further advancement in this area.

Voice prostheses are known to fail in few weeks to several months of implantation due to the clogging mainly caused by microbial biofilm formation, which is a cause of concern. Iodine is a known broad-spectrum biocide and is reported to easily form complexes with various polymers. For long term device disinfection, strong iodine complexation that offers sustained iodine release for a prolonged period is essential. The present research work deals with the synthesis of a poly(methyl methacrylate- n -butyl acrylate- N -vinyl-2-pyrrolidone) (poly[MMA-BA-NVP]) tercopolymer through free radical polymerization for surface coating thermoplastic polyurethane (TPU) based voice prostheses. The NVP content in the tercopolymer was varied from 20% to 50% to optimise iodine loading and subsequent release. Base TPU coated with the tercopolymer was treated with 4% aqueous iodine solution at room temperature (28 ± 3 °C) for two hours. It was observed that the tercopolymer containing 35% N -vinyl-2-pyrrolidone (NVP), 32.5% methyl methacrylate (MMA) and 32.5% butyl acrylate ( n BA) gave a stable coating on TPUs together with sustained iodine release for a prolonged period. Furthermore, the tercopolymer coated and iodine loaded TPUs exhibited excellent antimicrobial activity against Candida albicans , Staphylococcus aureus and Escherichia coli .

Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity on titanium surfaces, surface modification techniques such as titanium nanotubes have been studied as nanotube surfaces can hold therapeutic drugs and molecules. The main aim of the present research work is to study the early osseointegration around the novel Simvastatin drug eluting nanotubular dental implant. In the present research, the titanium nanotubes were fabricated on the screw-shaped dental implant surface and the Simvastatin drug was loaded into the nanotubes using the ultrasonication dip method . In vitro and In vivo studies were carried out on the modified dental implants . In vitro cell culture study reported enhanced osteogenic activity on the drug-loaded nanotube surface implants. The in vivo animal studies were evaluated by micro-CT, histopathology, and reverse torque removal analysis methods. The test results showed faster osseointegration with the strong interface on the Simvastatin drug-loaded implant surface at 4 weeks of healing as compared to the control implants., Competing Interests: The authors confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome. The author also confirm that this manuscript has not been published previously, and it is not under consideration for the publication elsewhere. All authors have confirmed the submission of this manuscript., (© 2023 The Authors.)

Tissue engineering is a field which aims to regenerate damaged tissues by enhancing tissue growth through the porous architecture of the scaffolds which is desired to mimic the human cancellous bone. Mg-based scaffolds are gaining importance in the field of tissue engineering owing to its potential application as a biomaterial. However, fabrication of porous Mg remains a daunting task due to its highly reactive nature. In the present work, a novel Mg-based open cell porous structure with pore interconnectivity and significant strength is successfully fabricated using powder metallurgy approach and Ti-woven wire mesh as a space holding material. Pore morphology and percentage porosity can be easily altered by adjusting the Ti-wire diameter and shape of construct. SEM, EDX and µ-CT analysis were performed to assess the microstructural properties of the fabricated scaffold which revealed a uniform distribution of pores with porosity varying in range 50-60%. The measured values of ultimate compressive strength and elastic modulus using quasi static compression test were found to be 101 MPa and 2 GPa, respectively. Further to improve corrosion resistance of fabricated scaffold, alloying and coating were carried out. Preliminary degradation study as well as cytocompatibility studies using L929 cells was carried out to validate the potential of fabricated scaffold for bone healing/repair applications. Fabricated porous structures showed improved corrosion resistance as well as cell viability of more than 90%, suggesting it as a promising development for bone scaffolding applications in future., (Copyright © 2019 Elsevier Ltd. All rights reserved.)