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We describe a cardiac transplant patient who had human cutaneous alternariosis with a sporotrichoid distribution of skin lesions. In this patient identification of the causative organism Alternaria infectoria was achieved by sequencing the rDNA internal transcribed spacer domain. Treatment with itraconazole led to clinical resolution within 4 months. [ABSTRACT FROM AUTHOR]

The article discusses the prevalence of atopic dermatitis (AD) in China. It states that the prevalence of AD declined to 4.76 and 4.62 percent. It cites that a significant number of cases of mild phenotypes could not fulfill diagnostic criteria. It mentions that few Chinese dermatologists recognized the gap between Chinese and international view on diagnostic criteria of AD.

A letter to the editor is presented related to inflammation in cutaneous lupus erythematosus due to nitrosative stress.

A letter to the editor is presented regarding three siblings with haematomas but the dermatological examination considered Gardner-Diamond syndrome (GDS).

A letter to the editor is presented in response to the article about the effectiveness of methotrexate in the treatment of cutaneous lupus erythematosus published in the previous issue.

Presents a letter to the editor about the treatment of Wegener's granulomatosis.

Examines the diagnosis of Hailey-Hailey disease in woman with pruritic skin lesions on the trunk and limbs. Predominance of recurrent erosive skin lesions in intertriginous areas; Treatment of the disease with topical steroids and radiotherapy; Development of erythematous papules and erythematous plaques on the back, abdomen and limbs.

This study presents the case of a 38-year-old patient from Pakistan with vitiligo, who developed multiple verrucous papules on the palms and soles several years after receiving “herbal treatment” from a travelling Indian doctor for a period of 12 months. Histopathological examination showed changes consistent with the diagnosis of arsenical keratosis. Molecular-biological examination of a skin biopsy detected an atypical human papillomavirus. This observation supports the concept of human papillomavirus as a co-factor in the pathogenesis of premalignant arsenic-induced skin tumours. [ABSTRACT FROM AUTHOR]

Summary Background The tumour necrosis factor-related apoptosis-inducing ligand TRAIL has been shown to participate in the pathogenesis of systemic lupus erythematosus (SLE). The accumulation of apoptotic cell debris has been hypothesized to induce this autoimmune inflammation, and TRAIL may trigger this programmed cell death. Furthermore, TRAIL is among the interferon (IFN)-regulated genes which are typically expressed in the peripheral blood of patients with acute SLE. Objectives As an inappropriate activation of the type I IFN system plays an important role in both SLE and cutaneous lupus erythematosus (CLE) subsets, we hypothesized that TRAIL might also participate in the pathogenesis of CLE. Methods Immunohistochemistry and immunofluorescence analyses were used to identify and localize TRAIL-expressing cells in CLE skin specimens. TRAIL expression in peripheral blood mononuclear cells (PBMC) isolated from patients with CLE was measured by flow cytometry. The impact of IFN-α treatment on TRAIL expression by keratinocytes and PBMC was evaluated by reverse transcription-polymerase chain reaction and flow cytometry. Results Keratinocytes are beside CD11c+ and BDCA2+ dendritic cells the major TRAIL-expressing cells in CLE lesions. TRAIL is upregulated on the surface of circulating CD11c+ PBMC isolated from patients with CLE. Treatment of keratinocytes and PBMC with recombinant IFN-α strongly enhances TRAIL expression by these cells. The proapoptotic TRAIL receptor R1 is expressed by keratinocytes in CLE skin lesions. Conclusions TRAIL is strongly expressed in the skin and the blood of patients with CLE and may trigger the apoptotic death of kerationcytes in CLE via the TRAIL receptor R1. An IFN-α-induced TRAIL expression may in this way participate in the pathogenesis of CLE. [ABSTRACT FROM AUTHOR]

Presents a response to a letter to the editor regarding the article "Safety of Rush Insect Venom Immunotherapy. Results of a Retrospective Study in 178 Patients," previously published in the periodical "Allergy."

This study presents the case of a 38-year-old patient from Pakistan with vitiligo, who developed multiple verrucous papules on the palms and soles several years after receiving “herbal treatment” from a travelling Indian doctor for a period of 12 months. Histopathological examination showed changes consistent with the diagnosis of arsenical keratosis. Molecular-biological examination of a skin biopsy detected an atypical human papillomavirus. This observation supports the concept of human papillomavirus as a co-factor in the pathogenesis of premalignant arsenic-induced skin tumours. [ABSTRACT FROM AUTHOR]

Studies the role of dendritic cells in allergy. Types of dendritic cells; Ontogenesis; Antigen uptake; Migration and maturation of dendritic cells; Antigen presentation.