151. Regulation of type I and type III interferon induction in response to pathogen sensing.
- Author
-
Gewaid H and Bowie AG
- Subjects
- Humans, Animals, Host-Pathogen Interactions immunology, Receptors, Pattern Recognition metabolism, Receptors, Pattern Recognition immunology, Gene Expression Regulation immunology, Immunity, Innate, Pathogen-Associated Molecular Pattern Molecules immunology, Pathogen-Associated Molecular Pattern Molecules metabolism, Interferon Type I metabolism, Interferon Type I immunology, Signal Transduction immunology, Interferon Lambda, SARS-CoV-2 immunology, Interferons metabolism, Interferons immunology, COVID-19 immunology, COVID-19 virology
- Abstract
Type I and III interferons (IFN-I and IFN-III) have a central role in the early antimicrobial response against invading pathogens. Induction of IFN-Is and IFN-IIIs arises due to the sensing by pattern recognition receptors of pathogen-associated molecular patterns (from micro-organisms) or of damage-associated molecular patterns (DAMPs; produced by host cells). Here, we review recent developments on how IFN-I and IFN-III expression is stimulated by different pathogens and how the signalling pathways leading to IFN induction are tightly regulated. We also summarise the growing knowledge of the sensing pathways that lead to IFN-I and IFN-III induction in response to severe acute respiratory syndrome coronavirus 2., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2024
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