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A simple and efficient Se-radical triggered cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones to the product of has been developed. The compounds and showed potent cancer cell-growth inhibition activities., A simple and efficient Se-radical triggered cyclization/substitution cascade reaction of alkyne-tethered cyclohexadienones to afford 5-hydroxy-3-selenyl-4a,8a-dihydro-2 -chromen-6(5 )-ones has been developed. This transformation the 3,5-diselenyl-4a,8a-dihydro-2 -chromen-6(5 )-one intermediate followed by hydrolysis in the presence of CsOAc affords the desired product . The resulting products were tested for their anticancer activity using MTT assay, and compounds and showed potent cancer cell-growth inhibition activities.

To calculate the public transit accessibility value and its differences in a particular area to surrounding regions, this paper raised a new concept-- Area Public Transit Accessibility (APTA). This concept is based on the passenger travel behavior, travel psychology hypothesis and the service range of transit network and road network. By using the software –ArcGIS, this paper established the formula and showed the calculation steps. This method was applied to evaluate the accessibility values of every traffic zone in Beijing Chaoyang district. The results showed that the APTA can give us a clear description of the accessibility value level in a particular area to surrounding regions, which provides quantitative information for location analysis and public transit network optimization.

BACKGROUND: The nucleobindin 2 (NUCB2) gene encodes the NUCB2 protein, which plays a critical role in glucose metabolism and diabetes. This study explored the correlation between NUCB2 genetic variants and type 2 diabetes mellitus (T2DM). The study further examined the different NUCB2 variants that confer risk to T2DM in Chinese Han populations. METHODS: This study evaluated the anthropometric and glycemic profiles of 578 T2DM patients and 1,609 healthy controls. Subsequently, we genotyped five single nucleotide polymorphisms (SNPs) (rs10832756, rs1330, rs10766383, rs10832757, and rs11024251) in all the study participants using a Sequenom Mass ARRAY SNP genotyping platform. RESULTS: The distribution of polymorphisms was significantly different between the T2DM patients and healthy controls. Our logistic regression analysis results showed that the five NUCB2 SNPs are significantly correlated with the risk for T2DM, especially rs11024251(P=2.97×10(−6)). Interestingly, analysis of male and female sub-populations separately showed that only two of the SNPs (rs10832757 and rs11024251) have significant correlation to T2DM in males [P=0.0244, odds ratio (OR) 1.28 and P=0.0062, OR 1.35, respectively). In females however, we identified four significant SNPs (rs1330, rs10766383, rs10832757, and rs11024251; P

To analyze theFrom 2009 to 2014, 207 schistosomiasis endemic villages from 13 cities were selected as the surveillance sites in Hubei Province, where the surveillance of snail situation was performed, and the data about the indexes of snail situation during the 6 years were collected and analyzed statistically.From 2009 to 2014, totally 80 963.47 hmThe snail situation of Hubei Province has been declined steadily. However, the environment of snail breeding has not been changed completely. In order to consolidate the control achievements further, the measures including mollusciciding and snail control projects should be strengthened.

To establish an expression platform of surveillance and forecast for schistosomiasis in key water regions of Hubei Province.The platform of surveillance and forecast for schistosomiasis was established based on Google Earth, GIS Office software, network albums and network video stations. The results of the field surveillance and laboratory testing, and figures and videos were inputted into the established platform, and an information management file was set up to express the information of forecasting.The operation and expression platform based on Google Earth in key water regions of Hubei Province was successfully established. It was able to provide the forecasting data timely, to achieve off-site and real-time query and sharing.The platform based on Google Earth has preferable prospective on field application in Hubei Province.［

To evaluate the schistosomiasis transmission control in 19 counties (cities, districts) of Hubei Province in 2013.The epidemic villages from different counties were randomly sampled by the cluster sampling method as the evaluation villages. The schistosome infection status of human and livestock, theThe serum examination of schistosome infection was performed to 29 631 residents, and 2 068 were positive, with a positive rate of 6.98% (0.78% -16.47%). The stool examination was performed to 2 021 sero-positive persons, and 47 cases were stool-positive, with an infection rate of 0.16% (0 - 0.82%). The cattle was the main domestic animals in 19 counties (cities, districts), and the measures of replacing cattle with machine for cultivation were done in 17 counties (cities, districts). Totally 105 cattle in Caidian District and Huangpi District received stool examinations and no positives were detected. A total of 1 579.37 hmThe transmission of schistosomiasis in 19 counties (cities, districts) of Hubei Province has reached the standard of transmission controlled.

To grasp the distribution and epidemiology of confirmed cases of schistosomiasis in Hubei Province, so as to provide the evidence for promoting the prevention and control work.The confirmed cases of schistosomiasis in Hubei Province from 2010 to 2014 were epidemiologically investigated, and the prevalence characteristics and main influencing factors were analyzed.A total of 10 102 confirmed cases from 2010 to 2014 were surveyed. There were 1 062 local infected patients, accounting for 10.51% and including 354 repeated infections and 17 newly infected. There were 290 foreigninfected patients, accounting for 2.87%, with 206 repeated infection cases and 84 newly infected. There were 8 750 historical patients, including 2 229 patients who leaked the former schistosomiasis investigations, accounting for 22.06%; 570 patients missed treatment, accounting for 5.64%; 3 640 patients were treated with non-standard therapy, accounting for 36.03%; 2 311 patients were treated with poor medication efficacy, accounting for 22.88%. The multivariate non-conditional Logistic regression, targeting at confirmed cases in 2014, showed that, for the leaking investigations, the potential risk factors included the age, educational level, and latrine renovation (The epidemiological investigation on the confirmed cases of schistosomiasis could grasp the epidemic factors so as to improve the management and carry out the scientific control.

To analyze the surveillance results of schistosomiasis and understand the transmission situation in Hubei Province in 2014.According toIn the 207 sites, there were 27 sites without positive results of the blood tests and 129 sites without positive results of the stool tests. The infection rates of residents and cattle were 0.17% and 0, respectively. The density of living snails was 0.339 3 snails/0.1mThe endemic situation of schistosomiasis has decreased obviously in Hubei Province, and the whole province has achieved the criteria for transmission control of schistosomiasis.