151. Brain substrates of social decision-making in dual diagnosis: cocaine dependence and personality disorders
- Author
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Juan Verdejo-Román, Natalia Albein-Urios, José Miguel Martínez-González, Antonio Verdejo-García, and Carles Soriano-Mas
- Subjects
Pharmacology ,Ultimatum game ,medicine.diagnostic_test ,media_common.quotation_subject ,Medicine (miscellaneous) ,medicine.disease ,Personality disorders ,030227 psychiatry ,Cocaine dependence ,Developmental psychology ,03 medical and health sciences ,Psychiatry and Mental health ,0302 clinical medicine ,medicine.anatomical_structure ,Feeling ,medicine ,Social decision making ,Functional magnetic resonance imaging ,Psychology ,Insula ,030217 neurology & neurosurgery ,Anterior cingulate cortex ,media_common ,Clinical psychology - Abstract
Cocaine dependence frequently co-occurs with personality disorders, leading to increased interpersonal problems and greater burden of disease. Personality disorders are characterised by patterns of thinking and feeling that divert from social expectations. However, the comorbidity between cocaine dependence and personality disorders has not been substantiated by measures of brain activation during social decision-making. We applied functional magnetic resonance imaging to compare brain activations evoked by a social decision-making task-the Ultimatum Game-in 24 cocaine dependents with personality disorders (CDPD), 19 cocaine dependents without comorbidities and 19 healthy controls. In the Ultimatum Game participants had to accept or reject bids made by another player to split monetary stakes. Offers varied in fairness (in fair offers the proposer shares ~50 percent of the money; in unfair offers the proposer shares more...
- Published
- 2015
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