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Isoindolobenzazepine alkaloids are biogenetically linked to proterberines and are often classified as alkaloids of the isoquinoline type. As a class, they belong to the aporhoedane series obtained from Berberidacea from Chile. One good example of this alkaloid type is lennoxamine, whose synthesis can be approached in several ways such as vinyl azide chemistry, enamide photochemistry and electrophilic alkylation. Two new approaches for the synthesis of lennoxamine through radical cyclization are presented.

A modified version of the classical preparation of phenanthrenes was developed by using UV irradiation of stilbenes in the presence of an oxidant. The modification protocol involves the irradiation, in the presence of base, of stilbenes possessing a sulfonyl group linked to the central double bond and could be successfully applied for the synthesis of diverse phenanthrenes and phenanthrenoids.

Several studies are conducted to explain the formation, as well as the characterization of the single self-assembling [alpha],[gamma]-peptide nanotubes. The mechanisms associated with the [alpha],[gamma]-peptide nanotube templating of one-dimensional parallel fullerene arrangements are also discussed.

A photocyclization of tosylstilbenes in the presence of base is used as a key reaction for preparing the CC-1065 analogue.

The design and synthesis of an efficient and selective cyclic A fluorescent sensor is described. The design is refined to increase the affinity constant for cyclin A and also improve the energy transfer efficiency in order to enable the detection of endogenous levels of cyclin in cell lysates.

''Formal'' and standard ruthenium(II)-catalyzed [2+2+2] cycloaddition of 1,6-diynes to alkenes have produced bicyclic 1,3-cyclohexadienes. Density functional theory calculations have shown bicyclic and tricyclic 1,3-cyclohexadienes to be the major products.

A ruthenium-catalyzed tandem cyclization-decarbonylation is developed whereby 7-unsubstituted 1,6-diynes have given exo-alkylidenecyclopentanes. The starting point of this process might be the formation of a Ru-vinylidene complex.

The feasibility of a new type of palladium-catalyzed [4 + 3] intramolecular cycloaddition reaction is examined. This new cycloaddition has allowed the synthesis of appealing, stereochemically rich 5,7-fused bicyclic systems from dienylidenecyclopropanes.

The design and characterization of a novel multicomponent network of pyrene and dapoxyl-derivatives [alpha],[gamma]-cyclic peptides that display controlled fluorescent signal output is described. The network system might be particularly relevant for the development of new biosensor systems specifically tailored for studying networks involving homo- and heterodimerization processes.

A versatile method, which was developed for the preparation of C[alpha]-([omega]-arylalkynyl)glycines by means of Sonogashira-type reactions in mixtures of water with an organic solvent is presented. This new method is considered to be widely applicable to the assembly of modified peptides that are of pharmacological interest, and could be exploited for the manufacture of metal ion sensors, or could adopt predefined conformations upon complexation with metals.

A new, efficient Ru-catalyzed cyclization of terminal alkynes to cycloalkenes is described. Under appropriate catalytic conditions, cycloisomerization to conjugated aldehydes and new possibilities of C-C formation catalyzed by transition metal vinylidenes might be observed.

A new cascade reaction involving a Ru-catalyzed addition of alkenes to 1,6-[diynes.sup.6] followed by a thermal 6[e.sup.-]pi electrocyclization, is described. The results suggest that Ru-catalyzes addition of cyclic alkenes to 1,6-diynes to give (Z)-hexatrienes followed by thermal 6e(super -)pi electrocyclization to afford bicyclic cyclohexadienes.