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154. A prospective, observational study of fidaxomicin use for Clostridioides difficile infection in France.

Author

Guery, Benoit, Berger, Pierre, Gauzit, Remy, Gourdon, Magali, Barbut, Frédéric, DAFNE study group:, Bémer, Pascale, Bessède, Emilie, Camou, Fabrice, Cattoir, Vincent, Couzigou, Carine, Descamps, Dominique, Dinh, Aurélien, Laurans, Caroline, Lavigne, Jean-Philippe, Lechiche, Catherine, Leflon-Guibout, Véronique, Le Monnier, Alban, Levast, Marion, and Mootien, Joy Yoganaden

Published
2021
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155. Streptogramins for the treatment of infections caused by Gram-positive pathogens.

Author

Reissier, Sophie and Cattoir, Vincent

Abstract

Introduction: Streptogramins (pristinamycin and quinupristin-dalfopristin) can be interesting options for the treatment of infections due to Gram-positive cocci, especially multidrug-resistant isolates.Areas Covered: This review provides an updated overview of structural and activity characteristics, mechanisms of action and resistance, pharmacokinetic/pharmacodynamic, and clinical use of streptogramins.Expert Opinion: The streptogramin antibiotics act by inhibition of the bacterial protein synthesis. They are composed of two chemically distinct compounds, namely type A and type B streptogramins, which exert a rapid bactericidal activity against a wide range of Gram-positive bacteria (including methicillin-resistant staphylococci and vancomycin-resistant enterococci). Several mechanisms of resistance have been identified in staphylococci and enterococci but the prevalence of streptogramin resistance among clinical isolates remains very low. Even if only a few randomized clinical trials have been conducted, the efficacy of pristinamycin has been largely demonstrated with an extensive use for 50 years in France and some African countries. Despite its effectiveness in the treatment of severe Gram-positive bacterial infections demonstrated in several studies and the low rate of reported resistance, the clinical use of quinupristin-dalfopristin has remained limited, mainly due to its poor tolerance. Altogether, streptogramins (especially pristinamycin) can be considered as potential alternatives for the treatment of Gram-positive infections. [ABSTRACT FROM AUTHOR]

Published
2021
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162. Emergence of optrA-mediated linezolid resistance in enterococci from France, 2006–16

Author

Sassi, Mohamed, primary, Guérin, François, additional, Zouari, Asma, additional, Beyrouthy, Racha, additional, Auzou, Michel, additional, Fines-Guyon, Marguerite, additional, Potrel, Sophie, additional, Dejoies, Loren, additional, Collet, Anaïs, additional, Boukthir, Sarrah, additional, Auger, Gabriel, additional, Bonnet, Richard, additional, and Cattoir, Vincent, additional

Published
2019
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171. Rapid detection of Pseudomonas aeruginosa from positive blood cultures by quantitative PCR

Author

Cattoir Vincent, Gilibert Audrey, Le Glaunec Jeanne-Marie, Launay Nathalie, Bait-Mérabet Lilia, and Legrand Patrick

Subjects
Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Abstract Background Pseudomonas aeruginosa is responsible for numerous bloodstream infections associated with severe adverse outcomes in case of inappropriate initial antimicrobial therapy. The present study was aimed to develop a novel quantitative PCR (qPCR) assay, using ecfX as the specific target gene, for the rapid and accurate identification of P. aeruginosa from positive blood cultures (BCs). Methods Over the period August 2008 to June 2009, 100 BC bottles positive for gram-negative bacilli were tested in order to evaluate performances of the qPCR technique with conventional methods as gold standard (i.e. culture and phenotypic identification). Results Thirty-three strains of P. aeruginosa, 53 strains of Enterobactericaeae, nine strains of Stenotrophomonas maltophilia and two other gram-negative species were isolated while 3 BCs were polymicrobial including one mixture containing P. aeruginosa. All P. aeruginosa clinical isolates were detected by qPCR except a single strain in mixed culture. Performances of the qPCR technique were: specificity, 100%; positive predictive value, 100%; negative predictive value, 98.5%; and sensitivity, 97%. Conclusions This reliable technique may offer a rapid (

Published
2010
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172. Development and validation of a lateral flow immunoassay for rapid detection of VanA-producing enterococci.

Author

Oueslati, Saoussen, Volland, Hervé, Cattoir, Vincent, Bernabeu, Sandrine, Girlich, Delphine, Dulac, Ducan, Plaisance, Marc, Laroche, Maxime, Dortet, Laurent, Simon, Stéphanie, and Naas, Thierry

Subjects
IMMUNOASSAY, MEDICAL microbiology, ENTEROCOCCUS, AGAR plates, BACTERIAL growth, DETECTION limit, BACTERIAL proteins, VANCOMYCIN resistance, RESEARCH, RESEARCH methodology, VANCOMYCIN, MEDICAL cooperation, EVALUATION research, GRAM-positive bacterial infections, COMPARATIVE studies, ENZYMES
Abstract

Background: VRE are nosocomial pathogens with an increasing incidence in recent decades. Rapid detection is crucial to reduce their spread and prevent infections and outbreaks.Objectives: To evaluate a lateral flow immunoassay (LFIA) (called NG-Test VanA) for the rapid and reliable detection of VanA-producing VRE (VanA-VRE) from colonies and broth.Methods: NG-Test VanA was validated on 135 well-characterized enterococcal isolates grown on Mueller-Hinton (MH) agar (including 40 VanA-VRE). Different agar plates and culture broths widely used in routine laboratories for culture of enterococci were tested.Results: All 40 VanA-VRE clinical isolates were correctly detected in less than 15 min irrespective of the species expressing the VanA ligase and the medium used for bacterial growth. No cross-reaction was observed with any other clinically relevant ligases (VanB, C1, C2, D, E, G, L, M and N). Overall, the sensitivity and specificity of the assay were 100% for VanA-VRE grown on MH agar plates. NG-Test VanA accurately detects VanA-VRE irrespective of the culture medium (agar and broth). Band intensity was increased when using bacteria grown on vancomycin-containing culture media or on MH close to the vancomycin disc as a consequence of VanA induction. The limit of detection of the assay was 6.3 × 106 cfu per test with bacteria grown on MH plates and 4.9 × 105 cfu per test with bacteria grown on ChromID® VRE plates.Conclusions: NG-Test VanA is efficient, rapid and easy to implement in the routine workflow of a clinical microbiology laboratory for the confirmation of VanA-VRE. [ABSTRACT FROM AUTHOR]

Published
2021
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173. Brachyspira pilosicoli bloodstream infections: Case report and review of the literature

Author

Brun-Buisson Christian, Legrand Patrick, Thille Arnaud, Bait-Merabet Lilia, and Cattoir Vincent

Subjects
Therapeutics. Pharmacology, RM1-950, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Abstract Brachyspira pilosicoli is the etiologic agent of human and animal intestinal spirochetosis and is rarely implicated as a cause of bacteremia. Here, we describe the case of a B. pilosicoli spirochetemia in a 53-year-old male patient suffering from cardiogenic shock. This fastidious bacterium was isolated from blood, likely after translocation from the intestinal tract. Blood cultures were positive after 5 days of incubation (one day after the patient's death), highlighting the problem of the recovery of such type of fastidious bacterium. Identification was achieved by molecular methods (16S rRNA sequencing). A review of the English literature found only 8 cases of bacteremia caused by B. pilosicoli, mostly in immunocompromised or critically ill patients. Finally, difficulties in rapid and accurate diagnosis of B. pilosicoli bloodstream infections, in vitro antimicrobial susceptibility of human clinical isolates, and therapeutic options are discussed.

Published
2008
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174. Cerebral nocardiosis in a patient treated with pembrolizumab: a first case report.

Author

Paul, Petitgas, Mathieu, Lesouhaitier, Sarrah, Boukthir, Vincent, Cattoir, Pierre, Tattevin, François, Bénézit, Petitgas, Paul, Lesouhaitier, Mathieu, Boukthir, Sarrah, Cattoir, Vincent, Tattevin, Pierre, and Bénézit, François

Abstract

Background: Checkpoints inhibitors (CPIs) are increasingly used for the treatment of several malignancies. The most common side effects are Immune Related Adverse Events, while infectious complications are rare, especially cerebral nocardiosis.Case Presentation: Here, we report the first clinical case of a cerebral nocardiosis revealed after seizure in a patient treated by pembrolizumab for a metastatic lung cancer, in the absence of any additional immunosuppressive therapy or risk factors for cerebral nocardiosis. The extended evaluation including a brain CT-scan did not reveal any lesion before pembrolizumab. Nevertheless, the 3-month delay between the start of Pembrolizumab and the diagnosis of cerebral nocardiosis suggests that the infection occurred prior to the CPI. Unfortunately, the patient died during treatment for cerebral nocardiosis, while the lung cancer tumor mass had decreased by 80% after the sixth cycle of pembrolizumab.Conclusions: This case report emphasizes that clinicians should consider diagnoses other than metastasis in a patient with a brain mass and metastatic cancer treated with CPI, such as opportunistic infections or IRAE. [ABSTRACT FROM AUTHOR]

Published
2022
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177. Small RNAs in vancomycin-resistant Enterococcus faecium involved in daptomycin response and resistance

Author

Sinel, Clara, Augagneur, Yoann, Sassi, Mohamed, Bronsard, Julie, Cacaci, Margherita, Guerin, Francois, Sanguinetti, Maurizio, Meignen, Pierrick, Cattoir, Vincent, Felden, Brice, Unité de Recherche Risques Microbiens (U2RM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Università cattolica del Sacro Cuore [Milano] (Unicatt), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Normandie Université (NU), Ministere de l'Enseignement Superieur et de la Recherche [EA4655], Direction Generale pour l'Armement, Conseil Regional de Bretagne, region Bretagne [SAD SARS_2 9181], Marie Curie International Incoming Fellowship within the 7th European Community Framework Program [621959-SarHyb], Agence Nationale pour la Recherche (grant sRNA-fit), European Project: 621958,EC:FP7:PEOPLE,FP7-PEOPLE-2013-IIF,SARHYB(2014), Jonchère, Laurent, Large scale elucidation of the biological functions of the Staphylococcal RNome in genetic hybrid systems - SARHYB - - EC:FP7:PEOPLE2014-09-01 - 2016-08-31 - 621958 - VALID, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Multidisciplinary, Gene Expression Profiling, Enterococcus faecium, lcsh:R, lcsh:Medicine, Gene Expression Regulation, Bacterial, biochemical phenomena, metabolism, and nutrition, Article, Settore MED/07 - MICROBIOLOGIA E MICROBIOLOGIA CLINICA, Anti-Bacterial Agents, Vancomycin-Resistant Enterococci, RNA, Bacterial, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, Daptomycin, Humans, RNA, Small Untranslated, lcsh:Q, RNA, Messenger, Transcriptome, lcsh:Science, [SDV.MP] Life Sciences [q-bio]/Microbiology and Parasitology, Genome, Bacterial, Gram-Positive Bacterial Infections
Abstract

International audience; Vancomycin-resistant Enterococcus faecium is a leading cause of hospital-acquired infections and outbreaks. Regulatory RNAs (sRNAs) are major players in adaptive responses, including antibiotic resistance. They were extensively studied in gram-negative bacteria, but less information is available for gram-positive pathogens. No sRNAs are described in E. faecium. We sought to identify a set of sRNAs expressed in vancomycin-resistant E. faecium Aus0004 strain to assess their roles in daptomycin response and resistance. Genomic and transcriptomic analyses revealed a set of 61 sRNA candidates, including 10 that were further tested and validated by Northern and qPCR. RNA-seq was performed with and without subinhibitory concentrations (SICs) of daptomycin, an antibiotic used to treat enterococcal infections. After daptomycin SIC exposure, the expression of 260 coding and srna genes was altered, with 80 upregulated and 180 downregulated, including 51% involved in carbohydrate and transport metabolisms. Daptomycin SIC exposure significantly affected the expression of seven sRNAs, including one experimentally confirmed, sRNA_0160. We studied sRNA expression in isogenic mutants with increasing levels of daptomycin resistance and observed that expression of several sRNAs, including sRNA_0160, was modified in the stepwise mutants. This first genome-wide sRNA identification in E. faecium suggests that some sRNAs are linked to antibiotic stress response and resistance.

Published
2017

178. Large Eddy simulation of a supersonic ejector

Author

Cattoir, Vincent, UCL - Ecole polytechnique de Louvain, Bartosiewicz, Yann, and Chatelain, Philippe

Subjects
fluid mechanics, numerical simulation, LES, Supersonic ejectors
Abstract

Supersonic ejectors are a growing trend in our world where energetic efficiency becomes crucial.It is a passive device used to compress air using low grade energy. Fabri choking inside the ejector is a phenomenon known for years and Large-Eddy simulations are carried out in an attempt to have more informations about it. Master [120] : ingénieur civil mécanicien, Université catholique de Louvain, 2017

Published
2017

179. Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia.

Author

Monard, Céline, Pehlivan, Jonathan, Auger, Gabriel, Alviset, Sophie, Tran Dinh, Alexy, Duquaire, Paul, Gastli, Nabil, d'Humières, Camille, Maamar, Adel, Boibieux, André, Baldeyrou, Marion, Loubinoux, Julien, Dauwalder, Olivier, Cattoir, Vincent, Armand-Lefèvre, Laurence, Kernéis, Solen, the ADAPT study group, Becker, Agathe, Charpentier, Julien, and Textoris, Julien

Subjects
PNEUMONIA, RESEARCH, TIME, RESEARCH methodology, ANTI-infective agents, RETROSPECTIVE studies, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, COMMUNITY-acquired infections, POLYMERASE chain reaction
Abstract

Background: Improving timeliness of pathogen identification is crucial to allow early adaptation of antibiotic therapy and improve prognosis in patients with pneumonia. We evaluated the relevance of a new syndromic rapid multiplex PCR test (rm-PCR) on respiratory samples to guide empirical antimicrobial therapy in adult patients with community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP), and ventilator-acquired pneumonia (VAP).Methods: This retrospective multicenter study was conducted in four French university hospitals. Respiratory samples were obtained from patients with clinical and radiological signs of pneumonia and simultaneously tested using conventional microbiological methods and the rm-PCR. A committee composed of an intensivist, a microbiologist, and an infectious diseases specialist retrospectively assessed all medical files and agreed on the most appropriate antimicrobial therapy for each pneumonia episode, according to the results of rm-PCR and blinded to the culture results. The rm-PCR-guided antimicrobial regimen was compared to the empirical treatment routinely administered to the patient in standard care.Results: We included 159 pneumonia episodes. Most patients were hospitalized in intensive care units (n = 129, 81%), and episodes were HAP (n = 68, 43%), CAP (n = 54, 34%), and VAP (n = 37, 23%). Conventional culture isolated ≥ 1 microorganism(s) at significant level in 95 (60%) patients. The syndromic rm-PCR detected at least one bacteria in 132 (83%) episodes. Based on the results of the rm-PCR, the multidisciplinary committee proposed a modification of the empirical therapy in 123 (77%) pneumonia episodes. The modification was a de-escalation in 63 (40%), an escalation in 35 (22%), and undetermined in 25 (16%) patients. In microbiologically documented episodes (n = 95), the rm-PCR increased appropriateness of the empirical therapy to 83 (87%), as compared to 73 (77%) in routine care.Conclusions: Use of a syndromic rm-PCR test has the potential to reduce unnecessary antimicrobial exposure and increase the appropriateness of empirical antibiotic therapy in adult patients with pneumonia. [ABSTRACT FROM AUTHOR]

Published
2020
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180. Helcococcus kunzii methyltransferase Erm(47) responsible for MLSB resistance is induced by diverse ribosome-targeting antibiotics.

Author

Guerin, François, Rose, Simon, Cattoir, Vincent, and Douthwaite, Stephen

Subjects
ANTIBIOTICS, BINDING sites, DRUG resistance, DOSAGE forms of drugs, LINEZOLID, RIBOSOMAL proteins, ERYTHROMYCIN, RIBOSOMAL RNA
Abstract

Objectives: To determine the mechanism of induction of erm(47) and its atypical expression in the Gram-positive opportunistic pathogen Helcococcus kunzii, where it confers resistance to a subset of clinically important macrolide, lincosamide and streptogramin B (MLSB) antibiotics.Methods: The resistant H. kunzii clinical isolate UCN99 was challenged with subinhibitory concentrations of a wide range of ribosome-targeting drugs. The methylation status of the H. kunzii ribosomal RNA at the MLSB binding site was then determined using an MS approach and was correlated with any increase in resistance to the drugs.Results: The H. kunzii erm(47) gene encodes a monomethyltransferase. Expression is induced by subinhibitory concentrations of the macrolide erythromycin, as is common for many erm genes, and surprisingly also by 16-membered macrolide, lincosamide, streptogramin, ketolide, chloramphenicol and linezolid antibiotics, all of which target the 50S ribosomal subunit. No induction was detected with spectinomycin, which targets the 30S subunit.Conclusions: The structure of the erm(47) leader sequence functions as a hair trigger for the induction mechanism that expresses resistance. Consequently, translation of the erm(47) mRNA is tripped by MLSB compounds and also by drugs that target the 50S ribosomal subunit outside the MLSB site. Expression of erm(47) thus extends previous assumptions about how erm genes can be induced. [ABSTRACT FROM AUTHOR]

Published
2020
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181. A nationwide survey on involvement of clinical microbiologists in antibiotic stewardship programmes in large French hospitals.

Author

Le Maréchal, Marion, Agrinier, Nelly, Cattoir, Vincent, and Pulcini, Céline

Subjects
PUBLIC hospitals, MICROBIOLOGISTS, DRUG resistance in bacteria, TEACHING hospitals, HOSPITALS, MASS spectrometry, DIAGNOSIS methods
Abstract

Antibiotic stewardship programmes (ASP) are essential to tackle antibiotic resistance. Clinical microbiologists (CMs) play a key role in these programmes; however, few studies describe their actual involvement. Our objective was to explore CMs' involvement in French hospital ASP. In 2018, we conducted a survey among CMs working in large public French hospitals (600 acute care beds or more). The questionnaire focused on the following topics: microbiology department's characteristics, hospital ASP, and CMs' involvement in this programme, including their use of rapid diagnostic tests (RDT). Fifty/74 CMs answered (response rate 68%), with 68% working in a teaching hospital. CMs were leading the ASP in 6% of cases, and 57% of hospitals had a multidisciplinary antibiotic stewardship team. Most microbiology departments (92%) were using specific PCR, processed 24/7 in 74% of hospitals. More than half (58%) were using syndromic panel-based testing, 94% mass spectrometry, and 96% immunochromatographic/colorimetric RDT. Blood cultures were processed 24/7 in 44% of hospitals. CMs were involved in this. Finally, 42% of CMs wished to be more involved in their hospital's ASP, the most frequently reported barrier being lack of time (36%). CMs should be more involved in ASP. RDT are widely used, but not implemented in an optimal way. [ABSTRACT FROM AUTHOR]

Published
2019
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182. Elective distribution of resistance to beta-lactams among Enterobacter cloacae genetic clusters

Author

Garinet, Simon, primary, Fihman, Vincent, additional, Jacquier, Hervé, additional, Corvec, Stéphane, additional, Le Monnier, Alban, additional, Guillard, Thomas, additional, Cattoir, Vincent, additional, Zahar, Jean-Ralph, additional, Woerther, Paul-Louis, additional, Carbonnelle, Etienne, additional, Wargnier, Alain, additional, Kernéis, Solen, additional, and Morand, Philippe C, additional

Published
2018
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193. Erratum to ‘Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae’ [International Journal of Antimicrobial Agents 49/1 67–73]

Author

Zahar, Jean-Ralph, primary, Lesprit, Philippe, additional, Ruckly, Stephane, additional, Eden, Aurelia, additional, Hikombo, Hitoto, additional, Bernard, Louis, additional, Harbarth, Stephan, additional, Timsit, Jean-Francois, additional, Brun-Buisson, Christian, additional, Carlet, Jean, additional, Dellamonica, Pierre, additional, Gauzit, Remy, additional, Rabaud, Christian, additional, Zahar, Jean-Ralph, additional, Alfandari, Serge, additional, Cohen, Robert, additional, Coignard, Bruno, additional, Pulcini, Celine, additional, Robert, Jerome, additional, Aissa, Nejla, additional, Losniewski, Alain, additional, Henard, Sandrine, additional, Janssen, Cecile, additional, Pagani, Leonardo, additional, Bland, Stephane, additional, Gaillat, Jacques, additional, Bru, Jean Pierre, additional, Bonnin, Pierre, additional, Clavere, Gaelle, additional, Vitrat, Virginie, additional, Maulin, Laurence, additional, Quarsaet, Luc, additional, Roger, Helene, additional, Euzen, Jean-Baptiste, additional, Denes, Eric, additional, Couve-Daecon, Elodie, additional, Lechiche, Catherine, additional, Lavigne, Jean-Philippe, additional, Mondain, Veronique, additional, Garnier, Veronique, additional, Lambert, Dorothee, additional, Hentzien, Maxime, additional, Nguyen, Yohan, additional, Talarmin, Jean Paul, additional, Rameau, Pascaline, additional, Geffroy, Francoise, additional, Salmon-Rousseau, Arnaud, additional, Cattoir, Vincent, additional, Froissart, Antoine, additional, Aberrane, Said, additional, Legout, Laurence, additional, Roblot, France, additional, Beraud, Guillaume, additional, Pavese, Patricia, additional, Belmonte, Olivier, additional, Traversier, Nicolas, additional, Bellec, Laurent, additional, Lagrange-Xelot, Marie, additional, Moiton, Marie-Pierre, additional, Kuli, Barbara, additional, Longuet, Pascal, additional, Scanvic, Agnes, additional, Colombain, Lea, additional, Ferreyra, Milagros, additional, Jean, Maxime, additional, Laurens, Etienne, additional, Saada, Matthieu, additional, Aumaitre, Hugues, additional, Malet, Martine, additional, Roustant, Frederique, additional, LeMoing, Vincent, additional, Helene, Jean-Pierre, additional, Theodore, Jonathan, additional, Garandeau, Caroline, additional, Caillon, Jocelyne, additional, Olivero, Benjamin, additional, Boutoille, David, additional, Lepelletier, Didier, additional, Grandiere-Perez, Lucia, additional, Beaudron, Aurelie, additional, Ramanantsoa, Celine, additional, Varache, Catherine, additional, Varache, Nicolas, additional, Crochette, Nicolas, additional, Hitoto, Hikombo, additional, Blanchi, Sophie, additional, Penn, Pascale, additional, Louis, Bernard, additional, Vanjak, Dominique, additional, Escande, Marie-Christine, additional, Patrigeon, Rene-Gilles, additional, Honore, Stephanie, additional, Barrelet, Audrey, additional, Amara, Marlene, additional, Galempoix, Jean-Marc, additional, Reveil, Jean-Claude, additional, Bucchiotty, Patricia, additional, Couzigou, Carine, additional, LeMonnier, Alban, additional, Boidin, Emilie, additional, Sire, Stephane, additional, Luizy, Nelly, additional, Bronstain, Caroline, additional, Fankhauser, Carolina, additional, Brossier, Caroline, additional, von Dach, Elodie, additional, Sauve, Colette, additional, Adam, Marie-Noelle, additional, Hocqueloux, Laurent, additional, Bret, Laurent, additional, Andre, Marie-Helene, additional, Barruet, Regine, additional, Challier, Marion, additional, Cabie, Andre, additional, Roze, Benoit, additional, Plesiat, Patrick, additional, Jeanot, Katy, additional, Patry, Isabelle, additional, Moreau, Josephine, additional, Chirouze, Catherine, additional, Laurent, Aaron, additional, Bachelier, Marie-Nadege, additional, Kac, Guillaume, additional, Farthouat, Nicolas, additional, Feuillebois, Nicolas, additional, Guimard, Thomas, additional, Bourdon, Sandra, additional, Nguyen, Sophie, additional, Bentayeb, Houcine, additional, Albertini, Mari-Therese, additional, Marchou, Bruno, additional, Gaudre, Noemie, additional, Dubois, Damien, additional, Guillet-Caruba, Christelle, additional, Populaire, Florence Doucet, additional, Fortineau, Nicolas, additional, Escaut, Leila, additional, Fihman, Vincent, additional, Raymond, Josette, additional, Kerneis, Solene, additional, Leflon-Guibout, Veronique, additional, Lefort, Agnes, additional, Dinh, Aurelien, additional, Roux, Anne-Laure, additional, Abgrall, Sophie, additional, Jaureguy, Francoise, additional, Lucet, Jean-Christophe, additional, Soismier, Nathalie, additional, Lopes, Amanda, additional, Cambau, Emmanuelle, additional, Manceron, Veronique, additional, and Barnaud, Guilene, additional

Published
2017
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195. Predominance of healthcare-associated cases among episodes of community-onset bacteraemia due to extended-spectrum β-lactamase-producing Enterobacteriaceae

Author

Zahar, Jean-Ralph, primary, Lesprit, Philippe, additional, Ruckly, Stephane, additional, Eden, Aurelia, additional, Hikombo, Hitoto, additional, Bernard, Louis, additional, Harbarth, Stephan, additional, Timsit, Jean-François, additional, Brun-Buisson, Christian, additional, Aissa, Nejla, additional, Losniewski, Alain, additional, Henard, Sandrine, additional, Rabaud, Christian, additional, Janssen, Cécile, additional, Pagani, Léonardo, additional, Bland, Stéphane, additional, Gaillat, Jacques, additional, Bru, Jean Pierre, additional, Bonnin, Pierre, additional, Clavère, Gaelle, additional, Vitrat, Virginie, additional, Maulin, Laurence, additional, Quarsaet, Luc, additional, Roger, Helene, additional, Euzen, Jean-Baptiste, additional, Denes, Eric, additional, Couve-Daecon, Elodie, additional, Lechiche, Catherine, additional, Lavigne, Jean-Philippe, additional, Mondain, Véronique, additional, Pulcini, Celine, additional, Garnier, Veronique, additional, Lambert, Dorothée, additional, Hentzien, Maxime, additional, Nguyen, Yohan, additional, Talarmin, Jean Paul, additional, Rameau, Pascaline, additional, Geffroy, Françoise, additional, Salmon-Rousseau, Arnaud, additional, Cattoir, Vincent, additional, Froissart, Antoine, additional, Aberrane, Said, additional, Legout, Laurence, additional, Roblot, France, additional, Beraud, Guillaume, additional, Pavese, Patricia, additional, Belmonte, Olivier, additional, Traversier, Nicolas, additional, Bellec, Laurent, additional, Lagrange-Xelot, Marie, additional, Moiton, Marie-Pierre, additional, Kuli, Barbara, additional, Longuet, Pascal, additional, Scanvic, Agnes, additional, Colombain, Lea, additional, Ferreyra, Milagros, additional, Jean, Maxime, additional, Laurens, Etienne, additional, Saada, Matthieu, additional, Aumaitre, Hugues, additional, Malet, Martine, additional, Roustant, Frederique, additional, LeMoing, Vincent, additional, Helene, Jean-Pierre, additional, Theodore, Jonathan, additional, Garandeau, Caroline, additional, Caillon, Jocelyne, additional, Olivero, Benjamin, additional, Boutoille, David, additional, Lepelletier, Didier, additional, Grandière-Perez, Lucia, additional, Beaudron, Aurélie, additional, Ramanantsoa, Céline, additional, Varache, Catherine, additional, Varache, Nicolas, additional, Crochette, Nicolas, additional, Hitoto, Hikombo, additional, Blanchi, Sophie, additional, Penn, Pascale, additional, Louis, Bernard, additional, Vanjak, Dominique, additional, Escande, Marie-Christine, additional, Patrigeon, René-Gilles, additional, Honoré, Stéphanie, additional, Barrelet, Audrey, additional, Amara, Marlène, additional, Galempoix, Jean-Marc, additional, Réveil, Jean-Claude, additional, Bucchiotty, Patricia, additional, Couzigou, Carine, additional, LeMonnier, Alban, additional, Boidin, Emilie, additional, Sire, Stephane, additional, Luizy, Nelly, additional, Bronstain, Caroline, additional, Fankhauser, Carolina, additional, Brossier, Caroline, additional, von Dach, Elodie, additional, Sauve, Colette, additional, Adam, Marie-Noelle, additional, Hocqueloux, Laurent, additional, Bret, Laurent, additional, André, Marie-Hélène, additional, Barruet, Régine, additional, Challier, Marion, additional, Cabié, Andre, additional, Roze, Benoit, additional, Plesiat, Patrick, additional, Jeanot, Katy, additional, Patry, Isabelle, additional, Moreau, Joséphine, additional, Chirouze, Catherine, additional, Laurent, Aaron, additional, Bachelier, Marie-Nadège, additional, Kac, Guillaume, additional, Farthouat, Nicolas, additional, Feuillebois, Nicolas, additional, Guimard, Thomas, additional, Bourdon, Sandra, additional, Nguyen, Sophie, additional, Alfandari, Serge, additional, Bentayeb, Houcine, additional, Albertini, Mari-Thérèse, additional, Marchou, Bruno, additional, Gaudré, Noémie, additional, Dubois, Damien, additional, Guillet-Caruba, Christelle, additional, Doucet Populaire, Florence, additional, Fortineau, Nicolas, additional, Escaut, Leila, additional, Fihman, Vincent, additional, Gauzit, Rémy, additional, Raymond, Josette, additional, Kerneis, Solene, additional, Leflon-Guibout, Veronique, additional, Lefort, Agnes, additional, Dinh, Aurelien, additional, Roux, Anne-Laure, additional, Abgrall, Sophie, additional, Jauréguy, Françoise, additional, Lucet, Jean-Christophe, additional, Soismier, Nathalie, additional, Lopes, Amanda, additional, Cambau, Emmanuelle, additional, Manceron, Veronique, additional, and Barnaud, Guilène, additional

Published
2017
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196. Pharmacokinetics of Intraperitoneal Daptomycin in Patients with Peritoneal Dialysis-Related Peritonitis

Author

Paul, Laure Peyro Saint, primary, Ficheux, Maxence, additional, Debruyne, Danièle, additional, Loilier, Magalie, additional, Bouvier, Nicolas, additional, Morello, Rémy, additional, Parienti, Jean-Jacques, additional, Verdon, Renaud, additional, Fournel, François, additional, Cattoir, Vincent, additional, and Lobbedez, Thierry, additional

Published
2017
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199. Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects

Author

Daillère, Romain, primary, Vétizou, Marie, additional, Waldschmitt, Nadine, additional, Yamazaki, Takahiro, additional, Isnard, Christophe, additional, Poirier-Colame, Vichnou, additional, Duong, Connie P.M., additional, Flament, Caroline, additional, Lepage, Patricia, additional, Roberti, Maria Paula, additional, Routy, Bertrand, additional, Jacquelot, Nicolas, additional, Apetoh, Lionel, additional, Becharef, Sonia, additional, Rusakiewicz, Sylvie, additional, Langella, Philippe, additional, Sokol, Harry, additional, Kroemer, Guido, additional, Enot, David, additional, Roux, Antoine, additional, Eggermont, Alexander, additional, Tartour, Eric, additional, Johannes, Ludger, additional, Woerther, Paul-Louis, additional, Chachaty, Elisabeth, additional, Soria, Jean-Charles, additional, Golden, Encouse, additional, Formenti, Silvia, additional, Plebanski, Magdalena, additional, Madondo, Mutsa, additional, Rosenstiel, Philip, additional, Raoult, Didier, additional, Cattoir, Vincent, additional, Boneca, Ivo Gomperts, additional, Chamaillard, Mathias, additional, and Zitvogel, Laurence, additional

Published
2016
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