13,521 results on '"Cheng, Liu"'
Search Results
152. Advancements on the impact of hydroxychloroquine in systemic lupus erythematosus
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Peng-Cheng, Liu, Meng-Na, Lv, Jian-Bin, Li, Shu-Jiao, Yu, and Wu, Rui
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- 2024
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153. A case of surgery-cured scrotal Paget's disease presenting as a huge cauliflower-like mass
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Wei-Kun Zeng, Hai-Cheng Liu, Yuan-Hu Yuan, and Xiao-Feng Zou
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Extramammary Paget's disease ,Scrotum ,Local excision ,Surgery ,RD1-811 - Published
- 2024
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154. Editorial: Astrometry with the Chinese space station telescope
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Shi-Long Liao, Zhao-Xiang Qi, and Jia-Cheng Liu
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astrometry ,astrometric binaries ,reference frame ,proper motion ,parallax ,CSST survey ,Astronomy ,QB1-991 ,Geophysics. Cosmic physics ,QC801-809 - Published
- 2024
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155. Taxonomic and functional dynamics of nirS denitrifiers along a salinity gradient in the Pearl River Estuary
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Hongwei Zhou, Hao Zhang, Xinping He, Cheng Liu, Fozia, Qian Cui, Hongjun Yang, Chunyu Zhao, Han Zhang, Huanhuan Hu, and Zongxiao Zhang
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estuary environments ,denitrification ,nirS gene ,denitrifier diversity ,geographical separation ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Understanding the factors that shape the diversity, distribution, and function of denitrifying microbes is vital for managing nitrogen cycling in these ecosystems. This study explores the diversity, biogeographic distribution, assembly processes, interaction, and denitrification potential of the nirS-encoding microbial community (nirS denitrifier) in the Pearl River Estuary based on high-throughput and metagenomics sequencing dataset. The results of this study show that salinity is a crucial regulatory environmental factor that determines the spatial distribution, phylogenetic turnover, and co-occurrence patterns of nirS denitrifiers. Additionally, the dissolved organic carbon (DOC), suspended sediment concentration (SSC), and dissolved oxygen (DO) in water also significantly impact the biodiversity and abundance of nirS denitrifiers. Furthermore, our findings demonstrate that, in comparison to environmental factors, the ecological and evolutionary characteristics of nirS denitrifiers play a more prominent role in regulating their denitrification potential, suggesting that alterations in the microbial community within dynamic changes in estuarine water can profoundly affect its denitrification function. Our results indicate the significant roles of denitrification microbial structure and phylogenetic characteristics in maintaining their ecological functions. Future studies should continue to explore the interactions between microbial communities and environmental factors to further elucidate the denitrification process in estuaries and its implications for ecosystem health and water quality.
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- 2024
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156. Can public opinions improve the effect of financial early warning ? -- an empirical study on the new energy industry
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Ziya Yang, Yucheng Zhu, Jiaxin Chen, Songyan Xie, and Cheng Liu
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New energy ,Early warning system ,Sentiment analysis ,Fanatical analysis ,Data mining ,Deep learning ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Public opinion will significantly affect investor decision-making and stock prices, which ultimately has an impact on the long-term development of the new energy industry. This paper mainly aims to delve in the impact of public opinion on the efficacy of financial risk early warning effect and try to establish an enhanced financial risk early warning model for the new energy list companies. To achieve this, we collect the financial data and public evaluation texts of 185 new energy listed companies, converting the text into emotional indicators which are combined with financial indicators to build a financial risk early warning model for new energy listed companies. The contributions of this paper are as follows: (1) The experiment validation demonstrates that the combination of 7 deep learning models and Bagging algorithm highly improves the accuracy of the sentiment analysis model, achieving an accuracy of 84.09%. (2) The accuracy of financial early warning models is generally enhanced after adding sentiment indicators, among which the accuracy of the BP neural network model reached 95.78%. (3) Through clustering analysis, the evaluation models can productively divide the warning intervals, thereby bolstering the interpretability and applicability of early warning results. Therefore, we suggest that when establishing the financial early warning system, it's necessary to take public opinions into consideration. Aside from improving the early warning effect, it also can be used as a separate indicator for daily monitoring.
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- 2024
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157. Nanodrug delivery systems for regulating microglial polarization in ischemic stroke treatment: A review
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Shuang-Yin Lei, Yu-Qian Yang, Jia-Cheng Liu, Dian-Hui Zhang, Yang Qu, Ying-Ying Sun, Hong-Jing Zhu, Sheng-Yu Zhou, Yi Yang, and Zhen-Ni Guo
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Biochemistry ,QD415-436 - Abstract
The incidence of ischemic stroke (IS) is rising in tandem with the global aging population. There is an urgent need to delve deeper into the pathological mechanisms and develop new neuroprotective strategies. In the present review, we discuss the latest advancements and research on various nanodrug delivery systems (NDDSs) for targeting microglial polarization in IS treatment. Furthermore, we critically discuss the different strategies. NDDSs have demonstrated exceptional qualities to effectively permeate the blood–brain barrier, aggregate at the site of ischemic injury, and target specific cell types within the brain when appropriately modified. Consequently, NDDSs have considerable potential for reshaping the polarization phenotype of microglia and could be a prospective therapeutic strategy for IS. The treatment of IS remains a challenge. However, this review provides a new perspective on neuro-nanomedicine for IS therapies centered on microglial polarization, thereby inspiring new research ideas and directions.
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- 2024
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158. Comparison of postoperative analgesia and side effects in pediatric laparoscopic surgery with morphine and nalbuphine
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Jia Chen, Cheng-Yu Wang, John Wei Zhong, Yu-Hang Cai, Jianmin Zhang, Fang Wang, Mazhong Zhang, Hongbin Gu, Hong-Yu Ma, Zhen Wang, Junzheng Wu, and Hua-Cheng Liu
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Health sciences ,Medicine ,Medical specialty ,Surgery ,Pharmacology ,Natural sciences ,Science - Abstract
Summary: There is currently no consensus on the optimal perioperative pain management strategy involving specific opioids. This study aims to compare the postoperative analgesia, the associated side effects between nalbuphine and morphine in children undergoing laparoscopic surgery. One hundred ninety children were randomly assigned to nalbuphine (0.2 mg/kg) or morphine (0.2 mg/kg). Nalbuphine’s analgesic effect was non-inferior to morphine, with similar total rescue analgesic consumption during PACU stay (0.03 ± 0.05mg vs. 0.04 ± 0.06 mg, p > 0.05). Nalbuphine group had a lower incidence of respiratory depression (RR ≤ 10/min) (4.8% vs. 38.6%, p
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- 2024
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159. A Complicated Route from Disorder to Order in Antimony–Tellurium Binary Phase Change Materials
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Yonghui Zheng, Wenxiong Song, Zhitang Song, Yuanyuan Zhang, Tianjiao Xin, Cheng Liu, Yuan Xue, Sannian Song, Bo Liu, Xiaoling Lin, Vladimir G. Kuznetsov, Ilya I. Tupitsyn, Alexander V. Kolobov, and Yan Cheng
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antimony–tellurium binary materials ,atomic structure ,phase transition mechanism ,phase‐change materials ,spherical aberration‐corrected transmission electron microscope ,Science - Abstract
Abstract The disorder‐to‐order (crystallization) process in phase‐change materials determines the speed and storage polymorphism of phase‐change memory devices. Only by clarifying the fine‐structure variation can the devices be insightfully designed, and encode and store information. As essential phase‐change parent materials, the crystallized Sb–Te binary system is generally considered to have the cationic/anionic site occupied by Sb/Te atoms. Here, direct atomic identification and simulation demonstrate that the ultrafast crystallization speed of Sb–Te materials is due to the random nature of lattice site occupation by different classes of atoms with the resulting octahedral motifs having high similarity to the amorphous state. It is further proved that after atomic ordering with disordered chemical occupation, chemical ordering takes place, which results in different storage states with different resistance values. These new insights into the complicated route from disorder to order will play an essential role in designing neuromorphic devices with varying polymorphisms.
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- 2024
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160. Therapeutic role of neural stem cells in neurological diseases
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Ling Yang, Si-Cheng Liu, Yi-Yi Liu, Fu-Qi Zhu, Mei-Juan Xiong, Dong-Xia Hu, and Wen-Jun Zhang
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NSCs ,neurological diseases ,treatment ,transplantation ,challenge ,Biotechnology ,TP248.13-248.65 - Abstract
The failure of endogenous repair is the main feature of neurological diseases that cannot recover the damaged tissue and the resulting dysfunction. Currently, the range of treatment options for neurological diseases is limited, and the approved drugs are used to treat neurological diseases, but the therapeutic effect is still not ideal. In recent years, different studies have revealed that neural stem cells (NSCs) have made exciting achievements in the treatment of neurological diseases. NSCs have the potential of self-renewal and differentiation, which shows great foreground as the replacement therapy of endogenous cells in neurological diseases, which broadens a new way of cell therapy. The biological functions of NSCs in the repair of nerve injury include neuroprotection, promoting axonal regeneration and remyelination, secretion of neurotrophic factors, immune regulation, and improve the inflammatory microenvironment of nerve injury. All these reveal that NSCs play an important role in improving the progression of neurological diseases. Therefore, it is of great significance to better understand the functional role of NSCs in the treatment of neurological diseases. In view of this, we comprehensively discussed the application and value of NSCs in neurological diseases as well as the existing problems and challenges.
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- 2024
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161. Immunomodulatory and anti-angiogenesis effects of excavatolide B and its derivatives in alleviating atopic dermatitis
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Hsiu-Wen Chen, Feng-Cheng Liu, Hsiao-Mei Kuo, Shih-Hsuan Tang, Guang-Hao Niu, Mingzi M. Zhang, Lun Kelvin Tsou, Ping-Jyun Sung, and Zhi-Hong Wen
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Atopic dermatitis ,inflammation ,angiogenesis ,skin barrier ,excavatolide B ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Atopic dermatitis (AD) is a chronic inflammatory skin condition primarily driven by T helper 2 (Th2) cytokines, resulting in skin barrier defects, angiogenesis, and inflammatory responses. The marine natural product excavatolide B (EXCB), isolated from the Formosan Gorgonian coral Briareum stechei, exhibits anti-inflammatory and analgesic properties. To enhance solubility, EXCB is chemically modified into the derivatives EXCB-61 salt and EXCB-79. The study aims to investigate the therapeutic effects of these compounds on dinitrochlorbenzene (DNCB)-induced skin damage and to elucidate the underlying anti-inflammatory and anti-angiogenesis mechanism. In vitro, using lipopolysaccharide (LPS)-induced RAW 264.7 cells, all compounds at 10 μM significantly inhibited expression of inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2), vascular endothelial growth factor (VEGF), and cytokines (interleukin (IL)−1β, IL-6, and IL-17A). In vivo, topical application of these compounds on DNCB-induced AD mice alleviated skin symptoms, reduced serum levels of IgE, IL-4, IL-13, IL-17, and interferon-γ, and moderated histological phenomena such as hyperplasia, inflammatory cell infiltration, and angiogenesis. The three compounds restored the expression of skin barrier-related proteins (loricrin, filaggrin, and claudin-1) and reduced the expression of angiogenesis-related proteins (VEGF and platelet endothelial cell adhesion molecule-CD31) in the tissues. This is the first study to indicate that EXCB, EXCB-61 salt, and EXCB-79 can treat AD disease by reducing inflammation and angiogenesis. Hence, they may be considered potential candidates for the development of new drugs for AD.
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- 2024
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162. Novel green and ecofriendly route for fabricating a robust corrosion protection coating on AZ91D magnesium alloy
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Shun-Yi Jian, Yu-Cheng Liu, and Chin-Jou Chang
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AZ91D magnesium alloy ,Green and ecofriendly ,Microstructure ,Electrochemical impedance spectroscopy (EIS) ,Salt spray test ,Industrial electrochemistry ,TP250-261 ,Chemistry ,QD1-999 - Abstract
Mg is the lightest structural metal on earth; hence, applications of its alloys have attracted attention from researchers. However, these alloys have poor corrosion resistance, which impedes their use in practice. Many researchers have investigated protective coatings for Mg alloys, but current methods consume much energy, use hazardous substances, or are complex (such as anodizing and micro-arc oxidation). This paper proposes a novel method of creating a durable and protective coating on Mg alloy substrates. The AZ91D Mg alloy was selected for investigation, and a Mn-V-P conversion coating treatment in which voltage of only 5 V was applied for 1 min to enhance the alloy’s corrosion resistance. A compact, single-layer film with uniform thickness was created; the average thickness was 1750 nm. The corrosion resistance of alloys treated with the method and through anodizing treatment was compared. For the novel coating, the corroded area fraction after a 168-h salt spray test was less than 5 %, superior to that for the coating produced through anodizing treatment. The feasibility and potential applications of the novel process are discussed.
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- 2024
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163. Synchronized measurement method for urban distribution networks based on proportional-integral control
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Xiaodong Yin, Jicheng Yu, Siyuan Liang, Junjie Liu, Jian Wang, Cheng Liu, and Wangwang Ding
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proportional-integral control ,synchronized sampling ,optimizing sampling accuracy ,synchronized phasor estimation ,urban distribution networks ,General Works - Abstract
In the context of the rising prevalence of renewable energy, the need for precise and synchronized measurements in urban distribution networks has become increasingly critical. Conventional synchronization techniques, which predominantly depend on Global Navigation Satellite System (GNSS) timing signals, are often plagued by significant sampling time errors. Addressing this challenge, this study introduces an innovative automatic synchronization measurement method employing proportional-integral (PI) control. This method is composed of three integral components: the monitoring of local clock phases via pulses per second (PPS) signals, modulation of the clock phase through a PI controller, and the estimation of grid phasors from the synchronized sampled data. The test results of this method on a hardware platform demonstrate its capability to significantly reduce the sampling error from 2 × 10−3 V to an impressive 1 × 10−5 V, while also meeting the requirements of the synchronized phasor measurement standards outlined in C37.118.1. These advancements underscore the significant potential of PI-controlled simultaneous sampling in enhancing the operational efficiency and reliability of urban distribution networks, particularly in environments with a high integration of renewable energy sources.
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- 2024
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164. Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs
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Chi-Ning Chuang, Hou-Cheng Liu, Tai-Ting Woo, Ju-Lan Chao, Chiung-Ya Chen, Hisao-Tang Hu, Yi-Ping Hsueh, and Ting-Fang Wang
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ciliate ,codon usage ,intrinsically disordered region ,meiosis ,polyglutamine ,replication slippage ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins. SCDs often are intrinsically disordered regions that mediate protein phosphorylation and protein-protein interactions. PolyQ and polyQ/N tracts are structurally flexible sequences that trigger protein aggregation. We report that due to their high percentages of STQ or STQN amino acid content, four SCDs and three prion-causing Q/N-rich motifs of yeast proteins possess autonomous protein expression-enhancing activities. Since these Q-rich motifs can endow proteins with structural and functional plasticity, we suggest that they represent useful toolkits for evolutionary novelty. Comparative Gene Ontology (GO) analyses of the near-complete proteomes of 26 representative model eukaryotes reveal that Q-rich motifs prevail in proteins involved in specialized biological processes, including Saccharomyces cerevisiae RNA-mediated transposition and pseudohyphal growth, Candida albicans filamentous growth, ciliate peptidyl-glutamic acid modification and microtubule-based movement, Tetrahymena thermophila xylan catabolism and meiosis, Dictyostelium discoideum development and sexual cycles, Plasmodium falciparum infection, and the nervous systems of Drosophila melanogaster, Mus musculus and Homo sapiens. We also show that Q-rich-motif proteins are expanded massively in 10 ciliates with reassigned TAAQ and TAGQ codons. Notably, the usage frequency of CAGQ is much lower in ciliates with reassigned TAAQ and TAGQ codons than in organisms with expanded and unstable Q runs (e.g. D. melanogaster and H. sapiens), indicating that the use of noncanonical stop codons in ciliates may have coevolved with codon usage biases to avoid triplet repeat disorders mediated by CAG/GTC replication slippage.
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- 2024
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165. Evaluation of deep learning computer vision for water level measurements in rivers
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Wen-Cheng Liu and Wei-Che Huang
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Deep learning ,SegNet ,Continuous image subtraction ,Water level measurement ,Image analysis ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Image-based gauging stations offer the potential for substantial enhancement in the monitoring networks of river water levels. Nonetheless, the majority of camera gauges fall short in delivering reliable and precise measurements because of the fluctuating appearance of water in the rivers over the course of the year. In this study, we introduce a method for measuring water levels in rivers using both the traditional continuous image subtraction (CIS) approach and a SegNet neural network based on deep learning computer vision. The historical images collected from on-site investigations were employed to train three neural networks (SegNet, U-Net, and FCN) in order to evaluate their effectiveness, overall performance, and reliability. The research findings demonstrated that the SegNet neural network outperformed the CIS method in accurately measuring water levels. The root mean square error (RMSE) between the water level measurements obtained by the SegNet neural network and the gauge station's readings ranged from 0.013 m to 0.066 m, with a high correlation coefficient of 0.998. Furthermore, the study revealed that the performance of the SegNet neural network in analyzing water levels in rivers improved with the inclusion of a larger number of images, diverse image categories, and higher image resolutions in the training dataset. These promising results emphasize the potential of deep learning computer vision technology, particularly the SegNet neural network, to enhance water level measurement in rivers. Notably, the quality and diversity of the training dataset play a crucial role in optimizing the network's performance. Overall, the application of this advanced technology holds great promise for advancing water level monitoring and management in river systems.
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- 2024
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166. Systemic immune–inflammation index for predicting postoperative atrial fibrillation following cardiac surgery: a meta-analysis
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Yu-Chou Chen, Chien-Cheng Liu, Hui-Chen Hsu, Kuo-Chuan Hung, Ying-Jen Chang, Chun-Ning Ho, Chung-Hsi Hsing, and Ching-Yi Yiu
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postoperative atrial fibrillation ,systemic immune-inflammation index ,cardiac surgery ,inflammation ,cardiopulmonary bypass ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
BackgroundPostoperative atrial fibrillation (POAF) is a frequent complication that may increase morbidity and mortality risk following cardiac surgery. The systemic immune–inflammation index (SII) is an emerging biomarker that provides an integrated measure of inflammation by incorporating neutrophil, lymphocyte, and platelet counts. Recent studies have reported associations between elevated SII and increased POAF risk; however, significant heterogeneity exists regarding its predictive efficacy. This meta-analysis aimed to assess SII's diagnostic efficacy for predicting POAF risk.MethodsTo synthesize existing evidence on the ability of perioperative SII for predicting POAF in patients undergoing cardiac surgery, a systematic review and meta-analysis was conducted. In August 2023, a comprehensive literature search was performed to identify relevant studies reporting SII cutoff values with corresponding sensitivity and specificity. The primary aim was to evaluate SII's diagnostic utility for predicting POAF, whereas secondary outcomes included the pooled incidence of POAF and the relationship between the SII and POAF.ResultsEight studies published between 2021 and 2023 with 3,245 patients were included. Six studies involved coronary artery bypass grafting (CABG) surgery; one encompassed various cardiac procedures, and another focused solely on mitral valve surgery. The pooled incidence of POAF was 23.6% [95% confidence interval (CI), 18.7%–29.2%]. Elevated SII significantly increased the odds of POAF by 3.24-fold (odds ratio, 3.24; 95% CI, 1.6–6.55; p = 0.001). SII's pooled sensitivity and specificity for predicting POAF were 0.80 (95% CI, 0.68–0.89) and 0.53 (95% CI, 0.23–0.8), respectively. The SII had moderate predictive accuracy based on a hierarchical summary receiver operating characteristic (HSROC) area under the curve of 0.78 (95% CI, 0.74–0.81). Subgroup analyses, whether focusing on CABG alone or CABG with cardiopulmonary bypass (CPB), both indicated an area under the HSROC curve of 0.78 (95% CI, 0.74–0.81).ConclusionElevated SII is significantly correlated with an increased POAF risk following cardiac surgery, highlighting its utility as a predictive biomarker. Considering its moderate diagnostic accuracy, further research is essential for clarifying SII's clinical effectiveness, either as an independent predictor or combined with other risk factors, for stratifying patients at high POAF risk.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier [CRD42023456128].
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- 2024
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167. Sustainable digital transformation path for manufacturing outwards foreign direct investment firms: Gradual or leapfrogging
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Xiaohua Yang, Cheng Liu, and Qiancheng Wei
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Digital transformation ,Outwards FDI ,Reverse technology spillover ,Cournot model ,Stackelberg model ,Evolutionary game model ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
Digital transformation plays an important role in improving the efficiency of production of enterprises and can provide strong support for green and sustainable development. Compared with domestic enterprises, outward foreign direct investment (OFDI) enterprises have greater access to advanced digital technology. This paper aims to analyze the path selection of green and sustainable production for the digital transformation of manufacturing outward foreign direct investment (OFDI) companies, whether gradual or leapfrogging. However, there is a lack of systemic game mechanisms and numerical simulation methods for heterogeneous enterprises. Based on the analysis of reverse technology spillover intensity of outward foreign direct investment (OFDI) and differences in the absorptive capacity of enterprises, we have proposed the evolutionary game model for different path selection of digital transformation of manufacturing enterprises, due to heterogeneous enterprises under different spillover degrees with numerical analysis methods. The research results show that: (i) Under low reverse technology spillover intensity, all enterprises evolve to a gradual transformation path, and enterprises with weaker absorptive capacity converge faster; (ii) There is a certain threshold for reverse technology spillover. When reverse technology spillover intensity exceeds the threshold, enterprises with stronger absorptive capacity converge to a leapfrog transformation path, but enterprises with weak absorptive capacity converge to a gradual transformation path; (iii) With high reverse technology spillover intensity, all enterprises evolve toward a leapfrog transformation path, and faster convergence happens to enterprises with higher absorptive capacity. The evolutionary game path of digital transformation in manufacturing enterprises is illustrated in Fig. 1.
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- 2024
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168. Establishment and comparison of different procedures for modeling intrauterine adhesion in rats: A preliminary study
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Peng-Cheng Liu, Yu-Ting Song, Long-Mei Zhao, Yan-Ling Jiang, Jun-Gen Hu, Li Dong, Xing-li Zhou, Li Zhou, Yaxing Li, Jesse Li-Ling, and Hui-Qi Xie
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Intrauterine adhesion ,Animal model ,Ethanol perfusion ,Chemical injury ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
The establishment of a stable animal model for intrauterine adhesion (IUA) can significantly enhance research on the pathogenesis and pathological changes of this disease, as well as on the development of innovative therapeutic approaches. In this study, three different modeling methods, including phenol mucilage combined mechanical scraping, ethanol combined mechanical scraping and ethanol modeling alone were designed. The morphological characteristics of the models were evaluated. The underlying mechanisms and fertility capacity of the ethanol modeling group were analyzed and compared to those of the sham surgery group. All three methods resulted in severe intrauterine adhesions, with ethanol being identified as a reliable modeling agent and was subsequently subjected to further evaluation. Immunohistochemistry and RT-PCR results indicated that the ethanol modeling group exhibited an increase in the degree of fibrosis and inflammation, as well as a significant reduction in endometrial thickness, gland number, vascularization, and endometrial receptivity, ultimately resulting in the loss of fertility capacity. The aforementioned findings indicate that the intrauterine perfusion of 95 % ethanol is efficacious in inducing the development of intrauterine adhesions in rats. Given its cost-effectiveness, efficacy, and stability in IUA formation, the use of 95 % ethanol intrauterine perfusion may serve as a novel platform for evaluating innovative anti-adhesion materials and bioengineered therapies.
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- 2024
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169. Development of high-concentration labeled colloidal gold immunochromatographic test strips for detecting african swine fever virus p30 protein antibodies
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Huai-cheng Liu, Rong-chao Liu, Mei-rong Hu, Ao-bing Yang, Ren-hu Wu, Yan Chen, Jin Zhang, Ji-shan Bai, Sheng-bo Wu, Jian-peng Chen, Yun-feng Long, Yan Jiang, and Bin Zhou
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African swine fever virus (ASFV) ,p30 protein ,Monoclonal antibody ,Colloidal gold immunochromatography ,High-concentration labeling ,Testing ,Science (General) ,Q1-390 ,Social sciences (General) ,H1-99 - Abstract
African Swine Fever (ASF), caused by the African swine fever virus (ASFV), has inflicted significant economic losses on the pig industry in China. The key to mitigating its impact lies in accurate screening and strict biosecurity measures. In this regard, the development of colloidal gold immunochromatographic test strips (CGITS) has proven to be an effective method for detecting ASFV antibodies. These test strips are based on the ASFV p30 recombinant protein and corresponding monoclonal antibodies. The design of the test strip incorporates a high-concentration colloidal gold-labeled p30 recombinant protein as the detection sensor, utilizing Staphylococcal Protein A (SPA) as the test line (T line), and p30 monoclonal antibody as the control line (C line). The sensitivity and specificity of the test strip were evaluated after optimizing the labeling concentration, pH, and protein dosage. The research findings revealed that the optimal colloidal gold labeling concentration was 0.05 %, the optimal pH was 8.4, and the optimal protein dosage was 10 μg/mL. Under these conditions, the CGITS demonstrated a detection limit of 1:512 dilution of ASFV standard positive serum, without exhibiting cross-reactivity with antibodies against other viral pathogens. Furthermore, the test strips remained stable for up to 20 days when stored at 50 °C and 4 °C. Comparatively, the CGITS outperformed commercial ELISA kits, displaying a sensitivity of 90.9 % and a specificity of 96.2 %. Subsequently, 108 clinical sera were tested to assess its performance. The data showed that the coincidence rate between the CGITS and ELISA was 93.5 %. In conclusion, the rapid colloidal gold test strip provides an efficient and reliable screening tool for on-site clinical detection of ASF in China. Its accuracy, stability, and simplicity make it a valuable asset in combating the spread of ASF and limiting its impact on the pig industry.
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- 2024
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170. Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response
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Changjiang Hu, Weichao Hu, Bo Tang, Qiyu Bao, Xingyu Jiang, Li Tang, He Wang, Lijiao He, Moyang Lv, Yufeng Xiao, Cheng Liu, Xinzhe Li, Yunyi Liu, Jie Li, Guiping Huang, Zhen Dong, Zhongjun Li, Tiannan Guo, and Shiming Yang
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Health sciences ,Immunity ,Microbiology ,Experimental models in systems biology ,Proteomics ,Science - Abstract
Summary: The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota analysis. We found that activation of the LXR/FXR pathway in plasma was associated with the production of ACE2-RBD-inhibiting antibodies, while urine proteins related to complement system, acute phase response signaling, LXR/FXR, and STAT3 pathways were correlated with neutralizing antibody production. Moreover, we observed a correlation between the gut microbiota and plasma and urine proteins, as well as the vaccination response. Based on the above data, we built a predictive model for vaccination response (AUC = 0.85). Our study provides insights into characteristic plasma and urine proteins and gut microbiota associated with the ACE2-RBD-inhibiting antibodies, which could benefit our understanding of the host response to COVID-19 vaccination.
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- 2024
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171. SCD1 is the critical signaling hub to mediate metabolic diseases: Mechanism and the development of its inhibitors
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Qin Sun, Xiaorui Xing, Huanyu Wang, Kang Wan, Ruobing Fan, Cheng Liu, Yongjian Wang, Wenyi Wu, Yibing Wang, and Ru Wang
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Stearoyl-CoA desaturase 1 ,Saturated fatty acids ,Monounsaturated fatty acids ,Metabolic homeostasis ,Metabolic diseases ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Metabolic diseases, featured with dysregulated energy homeostasis, have become major global health challenges. Patients with metabolic diseases have high probability to manifest multiple complications in lipid metabolism, e.g. obesity, insulin resistance and fatty liver. Therefore, targeting the hub genes in lipid metabolism may systemically ameliorate the metabolic diseases, along with the complications. Stearoyl-CoA desaturase 1(SCD1) is a key enzyme that desaturates the saturated fatty acids (SFAs) derived from de novo lipogenesis or diet to generate monounsaturated fatty acids (MUFAs). SCD1 maintains the metabolic and tissue homeostasis by responding to, and integrating the multiple layers of endogenous stimuli, which is mediated by the synthesized MUFAs. It critically regulates a myriad of physiological processes, including energy homeostasis, development, autophagy, tumorigenesis and inflammation. Aberrant transcriptional and epigenetic activation of SCD1 regulates AMPK/ACC, SIRT1/PGC1α, NcDase/Wnt, etc, and causes aberrant lipid accumulation, thereby promoting the progression of obesity, non-alcoholic fatty liver, diabetes and cancer. This review critically assesses the integrative mechanisms of the (patho)physiological functions of SCD1 in metabolic homeostasis, inflammation and autophagy. For translational perspective, potent SCD1 inhibitors have been developed to treat various types of cancer. We thus discuss the multidisciplinary advances that greatly accelerate the development of SCD1 new inhibitors. In conclusion, besides cancer treatment, SCD1 may serve as the promising target to combat multiple metabolic complications simultaneously.
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- 2024
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172. Scalar Flux Profiles in the Unstable Atmospheric Surface Layer Under the Influence of Large Eddies: Implications for Eddy Covariance Flux Measurements and the Non‐Closure Problem
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Heping Liu, Cheng Liu, Jianping Huang, Ankur R. Desai, Qianyu Zhang, Khaled Ghannam, and Gabriel G. Katul
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eddy covariance fluxes of scalars ,flux divergence and convergence ,large eddy simulations ,non‐closure of surface energy balance ,Geophysics. Cosmic physics ,QC801-809 - Abstract
Abstract How convective boundary‐layer (CBL) processes modify fluxes of sensible (SH) and latent (LH) heat and CO2 (Fc) in the atmospheric surface layer (ASL) remains a recalcitrant problem. Here, large eddy simulations for the CBL show that while SH in the ASL decreases linearly with height regardless of soil moisture conditions, LH and Fc decrease linearly with height over wet soils but increase with height over dry soils. This varying flux divergence/convergence is regulated by changes in asymmetric flux transport between top‐down and bottom‐up processes. Such flux divergence and convergence indicate that turbulent fluxes measured in the ASL underestimate and overestimate the “true” surface interfacial fluxes, respectively. While the non‐closure of the surface energy balance persists across all soil moisture states, it improves over drier soils due to overestimated LH. The non‐closure does not imply that Fc is always underestimated; Fc can be overestimated over dry soils despite the non‐closure issue.
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- 2024
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173. A numerical investigation into the propagation of acid-etched wormholes in geothermal wells
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Daobing Wang, Zhan Qu, Cheng Liu, Zongxiao Ren, Bo Yu, Qing Liu, Yongliang Wang, and Nai Hao
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Geothermal reservoir ,Acidification ,Wormhole propagation ,Finite element method ,Carbonate ,Energy conservation ,TJ163.26-163.5 ,Renewable energy sources ,TJ807-830 - Abstract
Carbonate geothermal reservoirs are widespread in the Beijing-Tianjin-Hebei region, and acidification stands out as the most effective method to enhance the heat recovery potential of these reservoirs. To understand the propagation patterns of acidized wormholes in geothermal reservoirs, a pore-Darcy scale mathematical model of acidizing reactions in geothermal reservoirs has been established. A normal random distribution function is introduced to depict the reservoir's heterogeneity. Using the finite element method, the study simulated the impact of injection rate, acid concentration, diffusion coefficient, and acid-rock reaction rate on wormhole morphology. The findings indicate that the reaction is uniform in the early stage of acidification, becoming non-uniform in the late stage, ultimately forming distinctive wormhole structures. The acidification radius is more extensive along a particular direction post-acidification. Increasing the acid injection rate, acid concentration, and initial specific surface area proves beneficial in enhancing the acidizing effect. The outcomes of this study hold theoretical and technical significance for optimizing the thermal recovery efficiency of geothermal reservoirs.
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- 2024
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174. Estimating the economic burden of colorectal cancer in China, 2019–2030: A population‐level prevalence‐based analysis
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Hong Wang, Yan‐Jie Li, Lin Lei, Cheng‐Cheng Liu, Wan‐Qing Chen, Min Dai, Xin Wang, Jie‐Bin Lew, Ju‐Fang Shi, Ni Li, and Jie He
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China ,colorectal cancer ,costs ,economic burden ,population‐level ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Colorectal cancer (CRC) is one of the most common cancers worldwide. Comprehensive data on the economic burden of CRC at a population‐level is critical in informing policymaking, but such data are currently limited in China. Methods From a societal perspective, the economic burden of CRC in 2019 was estimated, including direct medical and nonmedical expenditure, disability, and premature‐death‐related indirect expenditure. Data on disease burden was taken from the GBD 2019 and analyzed using a prevalence‐based approach. The per‐person direct expenditure and work loss days were from a multicenter study; the premature‐death‐related expenditure was estimated using a human capital approach. Projections were conducted in different simulated scenarios. All expenditure data were in Chinese Yuan (CNY) and discounted to 2019. Results In 2019, the estimated overall economic burden of CRC in China was CNY170.5 billion (0.189% of the local GDP). The direct expenditure was CNY106.4 billion (62.4% of the total economic burden), 91.4% of which was a direct medical expenditure. The indirect expenditure was CNY64.1 billion, of which 63.7% was related to premature death. The predicted burden would reach CNY560.0 billion in 2030 given constant trends for disease burden; however, it would be alternatively reduced to
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- 2024
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175. A 16-year meteotsunami climatology in the coastal areas of southern Asia-Pacific Ocean
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Li-Ching Lin, Wen-Cheng Liu, and Chin H. Wu
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meteotsunamis ,climatology ,Asia-Pacific Ocean ,convective storms ,hazard risks ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
This study presents the meteotsunami behavior in response to different storm types in the coasts of southern Asia-Pacific Ocean from 16 years water level records. Through the size- frequency analysis, the dangerous meteotsunami, wave height exceeding 0.3 m, can occur up to 44 events per year. Notably, during the extreme waves of the 2007 event, wave heights reached approximately 0.9-1.5 m in the Taiwan Strait and the western coastal areas of Taiwan. We have classified storms into six types by radar reflectivity images and satellite-derived precipitation. Findings indicate that predicted wave heights caused by bows and typhoons could reach hazardous magnitude of exceeding 2 m in a 100-yr interval. Spatial and temporal analysis reveals that meteotsunami occurrences are most frequent in the western regions during the winter to early spring months (December to April). Of all meteotsunami occurrences, cluster storms are identified as the most prevalent atmospheric forcing, accounting for 60% of meteostunamis. Typhoons have a 20% association with meteotsunamis along the east coasts of Taiwan during late summer to autumn. On the east coasts, typhoon type-induced events may be attributed to the combination effect of meteotsunamis and infra-gravity waves. Overall, this study provides the first comprehensive examination of meteotsunami-storm characteristics and their associated hazard risks in the coastal areas of the southern Asia-Pacific Ocean.
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- 2024
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176. Evaluation and identification of powdery mildew-resistant genes in 137 wheat relatives
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Jiaojiao Wang, Hongxing Xu, Yanmin Qie, Ran Han, Xiaohui Sun, Ya Zhao, Bei Xiao, Zejun Qian, Xiaomei Huang, Ruishan Liu, Jiadong Zhang, Cheng Liu, Yuli Jin, and Pengtao Ma
- Subjects
powdery mildew ,markers ,resistance identification ,haplotype analysis ,wheat relatives ,Genetics ,QH426-470 - Abstract
Powdery mildew is one of the most severe diseases affecting wheat yield and quality and is caused by Blumeria graminis f. sp. tritici (Bgt). Host resistance is the preferred strategy to prevent this disease. However, the narrow genetic basis of common wheat has increased the demand for diversified germplasm resources against powdery mildew. Wheat relatives, especially the secondary gene pool of common wheat, are important gene donors in the genetic improvement of common wheat because of its abundant genetic variation and close kinship with wheat. In this study, a series of 137 wheat relatives, including 53 Triticum monococcum L. (2n = 2x = 14, AA), 6 T. urartu Thumanjan ex Gandilyan (2n = 2x = 14, AA), 9 T. timopheevii Zhuk. (2n = 4x = 28, AAGG), 66 T. aestivum subsp. spelta (2n = 6x = 42, AABBDD), and 3 Aegilops speltoides (2n = 2x = 14, SS) were systematically evaluated for their powdery mildew resistance and composition of Pm genes. Out of 137 (60.58%) accessions, 83 were resistant to Bgt isolate E09 at the seedling stage, and 116 of 137 (84.67%) wheat relatives were resistant to the mixture of Bgt isolates at the adult stage. This indicates that these accessions show a high level of resistance to powdery mildew. Some 31 markers for 23 known Pm genes were used to test these 137 accessions, and, in the results, only Pm2, Pm4, Pm6, Pm58, and Pm68 were detected. Among them, three Pm4 alleles (Pm4a, Pm4b, and Pm4f) were identified in 4 T. subsp. spelta accessions. q-RT PCR further confirmed that Pm4 alleles played a role in disease resistance in these four accessions. The phylogenetic tree showed that the kinship of Pm4 was close to Pm24 and Sr62. This study not only provides reference information and valuable germplasm resources for breeding new wheat varieties with disease resistance but also lays a foundation for enriching the genetic basis of wheat resistance to powdery mildew.
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- 2024
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177. The analysis of low-dose glucocorticoid maintenance therapy in patients with primary nephrotic syndrome suffering from COVID-19
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Yong-Qi Li, Min Wu, Yu-Jia Wang, Yu-Xia Zhang, Jing Lu, Yi-Nan Zhao, Bo-Fan Ji, Zhi-Qing Chen, Ri-Ning Tang, and Bi-Cheng Liu
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coronavirus disease 2019 ,nephrotic syndrome ,low-dose glucocorticoids ,symptoms ,quality of life ,Biology (General) ,QH301-705.5 - Abstract
Objectives: This study aimed to describe the effects of low-dose (prednisolone acetate 2.5–7.5 mg/day) glucocorticoids (GCs) maintenance therapy in patients with primary nephrotic syndrome (NS) suffering from coronavirus disease 2019 (COVID-19).Methods: A single-center retrospective study of NS patients with COVID-19 infection in Zhongda Hospital Affiliated to Southeast University from 1 February 2022 to 31 March 2023 was conducted. All enrolled patients underwent renal biopsy for the pathological diagnosis and reached complete remission (CR) or near-CR before COVID-19 infection. According to the maintained therapy regimen, patients were divided into low-dose GCs group and non-GCs group.Results: A total of 125 patients were enrolled in the study. Their median age was 46.0 ± 15.6 years, and the median value of 24-h urine protein was 0.77 g. The majority of these patients received treatment for more than 6 months, with a significant portion achieving CR (29.6%) or near-CR (43.2%). The leading cause of NS was membranous nephropathy (52%). There were no significant differences in the baseline characteristics between low-dose GCs and non-GCs group. As compared to those in the non-GCs group, patients receiving low-dose GCs treatment showed less fatigue or muscle weakness, smell disorder, palpitations, decreased appetite, taste disorder, dizziness, sore throat or difficult to swallow and fever (p < 0.05). Moreover, patients in the low-dose GCs group were with higher median quality of life scores (85.0) than in the non-GCs group (p = 0.001). Further serum inflammatory factor analysis indicated that interleukin-6 (IL-6) levels in the non-GCs group were significantly higher than that in the low-dose GCs group (p < 0.05).Conclusion: Patients with NS in low-dose GCs maintenance therapy stage showed milder symptom, higher quality of life and decreased serum IL-6 levels compared to those, who were not on GCs maintenance therapy. These results suggest the beneficial effect of low-dose GCs therapy in NS patients with CR/near-CR suffering from COVID-19 infection.
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- 2024
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178. Investigation on the performance of proton exchange membrane water electrolyzer coupled with a catalyst layer pore network model
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Yiding Zeng, Maji Luo, Chaochao Qin, Cheng Liu, and Ben Chen
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Proton exchange membrane water electrolyzer ,Catalyst layer microstructures ,Pore network model ,Multi-scale model ,Performance analysis ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Improvement of performance and cost reduction are urgent issues for proton exchange membrane water electrolyzers (PEMWEs). This study explored ways to improve electrolyzer performance from the perspective of the catalyst layer (CL) microstructures. The pore network model of the CL was established, and the obtained structural, mass transfer and electrochemical parameters were coupled with the macroscale performance model of PEMWE to get the multi-scale performance model. The mass transfer, heat transfer, and electrochemical processes inside the electrolyzer were considered to improve the model's accuracy. The maximum error between the simulated results by this multi-scale performance model and the experimental data was verified to be only 3.1%. The verified model was then used to predict the electrolyzer performance with various cathode/anode catalyst layer (CCL/ACL) microstructures. The predicted results showed that the electrochemical activity surface area affects the performance of PEMWE to a much greater extent than the conductivity. The performance of PEMWE gradually deteriorated as the catalyst particle radius or pore diameter of the CCL/ACL increased by the same degree, and the catalyst particle radius had a relatively more significant impact on the performance of the electrolyzer. Overall, the variation of ACL structure had a more substantial effect on the electrolyzer performance than that of CCL.
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- 2024
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179. Impact of soil inorganic nitrogen on bacterial phylogeny in estuarine intertidal zones: a study of nitrogen metabolism
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Siqi Li, Tianyang Liu, Cheng Liu, Donglei Sun, Qin Yan, Dengzhou Gao, and Zongxiao Zhang
- Subjects
estuarine accommodation space ,soil inorganic nitrogen ,bacterial phylogenetic characterization ,nitrogen metabolism characteristics ,environmental response ,Microbiology ,QR1-502 - Abstract
Here we investigated the potential impacts of soil inorganic nitrogen (SIN) content on the phylogenetic characteristics and ecological functions of soil bacterial communities in estuarine intertidal zones in China, aiming to comprehend the response mechanism of soil microorganisms to variations in SIN content within estuarine wetlands. Our results show that SIN in estuarine areas has a significant spatiotemporal variation on spatial and seasonal scales, in this study and is significantly associated with the phylogenetic diversity and phylogenetic turnover of soil bacterial communities. In addition, the results of the metagenomic analysis showed that the relative abundance of nitrogen-cycling functional genes in bacterial communities did not differ significantly in sampling sites and seasons, and weakly correlated with SIN content. Further, the results based on structural equation modeling (SEM) analysis showed that SIN directly and significantly regulated the phylogenetic characteristics of bacterial communities, thereby indirectly affecting the potential of bacterial nitrogen metabolism. This study emphasizes the key influence of SIN variations on the phylogenetic dissimilarity in soil bacterial communities. Moreover, although there was a weak direct relationship between the functional characteristics of the bacterial nitrogen metabolism and SIN content, the spatiotemporal variation of bacterial nitrogen metabolic potential may be indirectly regulated by SIN content by influencing the phylogenetic diversity in bacterial communities. Our study unravels the pivotal mechanisms through which SIN content influences bacterial communities, thereby offering novel insights into the microbial intricacies governing nitrogen metabolism within estuaries.
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- 2024
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180. Overexpression of regulatory T cells in patients with unexplained recurrent pregnancy loss: friend or foe?
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Peng-cheng Liu, Jian-bin Li, Yi-ping Huang, Min Zhang, Shu-jiao Yu, and Rui Wu
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recurrent pregnancy loss ,pregnancy outcome ,regulatory T cells ,U-shaped association ,biomarker ,Medicine (General) ,R5-920 - Abstract
BackgroundThis study aimed to investigate the role of regulatory T cells in patients with unexplained recurrent pregnancy loss (URPL).MethodsWe retrospectively analyzed 136 women who had experienced two or more miscarriages before 24 weeks of gestation for no obvious reason from May 2018 to October 2021. The basic clinical data of the patients and expression of lymphocyte subsets such as regulatory T cells (Tregs) and natural killer cells (NKs) by flow cytometry were collected to explore the risk factors of pregnancy outcome in URPL patients.ResultsA total of 136 URPL patients were enrolled in this study. Eventually, 50 patients attained clinical pregnancy. The median age was 31.8 ± 4.6 years in patients with clinical pregnancy. The univariate and multivariate logistic regression analyses indicated that Tregs was associated with the pregnancy outcomes of patients with URPL (odds ratio 0.63, 95% confidence interval 0.50–0.80). More importantly, a U-shaped association was found between Tregs and pregnancy outcome (p
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- 2024
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181. Exploration of embedded technology based on Phytium E2000D in radio frequency physiotherapy.
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Mengxue Liu, Zhen Yang, and Cheng Liu
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- 2023
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182. A Novel Pulsar Analog Front-end for Grid Synchronized Measurement.
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Yao Zheng, Wei Qiu 0002, Sihao Tang, Zhangqing Chen, Cheng Liu, and Wenxuan Yao
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- 2023
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183. Development of Real-time High-Density Pulsar Data Transmission and Processing for Grid Synchronization.
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Wei Qiu 0002, Zhangqing Chen, Sihao Tang, Yao Zheng, Cheng Liu, He Yin, Yilu Liu, and Wenxuan Yao
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- 2023
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184. ScanNet++: A High-Fidelity Dataset of 3D Indoor Scenes.
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Chandan Yeshwanth, Yueh-Cheng Liu, Matthias Nießner, and Angela Dai
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- 2023
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185. Information Extraction of Bridge Structure Division and BIM Data-Driven Based on Text Mining.
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Cheng Liu, Junwu Mao, Mingze Liu, Shuangke Gou, Changqing Xie, and Yun Zhang
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- 2023
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186. An Electrical Impedance Spectroscopy IC with a Printable, Fractal Root Textile Sensor for Perspiration Analysis.
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Yung-Hua Yeh, Wei-Cheng Liu, Yi-Jie Lin, Yu-Siang Chou, Yu-Chiao Huang, Min-Hua Chang, I-Te Lin, Yen-Chi Chen, Ying-Chih Liao, and Yu-Te Liao
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- 2023
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187. Trainable Projected Gradient Method for Robust Fine-Tuning.
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Junjiao Tian, Xiaoliang Dai, Chih-Yao Ma, Zecheng He, Yen-Cheng Liu, and Zsolt Kira
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- 2023
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188. Text-Guided Unsupervised Latent Transformation for Multi-Attribute Image Manipulation.
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Xiwen Wei, Zhen Xu, Cheng Liu 0001, Si Wu 0002, Zhiwen Yu 0002, and Hau-San Wong
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- 2023
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189. Human-Machine Interface Evaluation Using EEG in Driving Simulator.
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Yuan-Cheng Liu, Nikol Figalová, Martin Baumann 0001, and Klaus Bengler
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- 2023
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190. DeepBurning-MixQ: An Open Source Mixed-Precision Neural Network Accelerator Design Framework for FPGAs.
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Erjing Luo, Haitong Huang, Cheng Liu 0008, Guoyu Li, Bing Yang, Ying Wang 0001, Huawei Li 0001, and Xiaowei Li 0001
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- 2023
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191. 3D Medical Axial Transformer: A Lightweight Transformer Model for 3D Brain Tumor Segmentation.
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Cheng Liu and Hisanor Kiryu
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- 2023
192. ATTAA: Active Text Traffic Analysis Attacks on Secure Messaging Applications.
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Fengyan Lv, Cheng Liu, Xiaofeng Liu 0013, Chengyu Hu, Zhihao Chen, and Shanqing Guo
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- 2023
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193. The Impact of Character Color Combinations on Legibility When Presented on Optical Head-Mounted Displays During Walking.
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De-Cheng Liu, Chih-Yu Hsiao, Wen-Yi Chen, and Chien-Chi Chang
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- 2023
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194. Layer-Puzzle: Allocating and Scheduling Multi-task on Multi-core NPUs by Using Layer Heterogeneity.
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Chengsi Gao, Ying Wang 0001, Cheng Liu 0008, Mengdi Wang, Weiwei Chen, Yinhe Han 0001, and Lei Zhang 0008
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- 2023
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195. A Study on the Effect of Ventilation Materials on Sound Quality of In-ear Earphones.
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Tzu-Hsuan Lei, Bo-Jyun Lan, Kuei-Hao Tseng, Kuang-Che Lo, Shu-Chien Wu, and Yu-Cheng Liu
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- 2023
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196. Adaptive Risk-Tendency: Nano Drone Navigation in Cluttered Environments with Distributional Reinforcement Learning.
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Cheng Liu, Erik-Jan van Kampen, and Guido C. H. E. de Croon
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- 2023
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197. SeaDroneSim: Simulation of Aerial Images for Detection of Objects Above Water.
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Xiaomin Lin, Cheng Liu, Allen Pattillo, Miao Yu 0007, and Yiannis Aloimonos
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- 2023
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198. Invasive Spartina alterniflora accelerates the increase in microbial nitrogen fixation over nitrogen removal in coastal wetlands of China
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Shuntao Chen, Dengzhou Gao, Xiaofei Li, Yuhui Niu, Cheng Liu, Dongyao Sun, Yanling Zheng, Hongpo Dong, Xia Liang, Guoyu Yin, Xianbiao Lin, Min Liu, and Lijun Hou
- Subjects
Salt marsh plant ,N removal ,N fixation ,N budget ,Estuarine and coastal ecosystems ,Ecology ,QH540-549.5 ,Environmental sciences ,GE1-350 - Abstract
Salt marsh plants play a vital role in mediating nitrogen (N) biogeochemical cycle in estuarine and coastal ecosystems. However, the effects of invasive Spartina alterniflora on N fixation and removal, as well as how these two processes balance to determine the N budget, remain unclear. Here, simultaneous quantifications of N fixation and removal via 15N tracing experiment with native Phragmites australis, invasive S. alterniflora, and bare flats as well as corresponding functional gene abundance by qPCR were carried out to explore the response of N dynamics to S. alterniflora invasion. Our results showed that N fixation and removal rates ranged from 0.77 ± 0.08 to 16.12 ± 1.13 nmol/(g·h) and from 1.42 ± 0.14 to 16.35 ± 1.10 nmol/(g·h), respectively, and invasive S. alterniflora generally facilitated the two processes rates. Based on the difference between N removal and fixation rates, net N2 fluxes were estimated in the range of −0.39 ± 0.14 to 8.24 ± 2.23 nmol/(g·h). Estimated net N2 fluxes in S. alterniflora stands were lower than those in bare flats and P. australis stands, indicating that the increase in N removal caused by S. alterniflora invasion may be more than offset by N fixation process. Random forest analysis revealed that functional microorganisms were the most important factor associated with the corresponding N transformation process. Overall, our results highlight the importance of N fixation in evaluating N budget of estuarine and coastal wetlands, providing valuable insights into the ecological effect of S. alterniflora invasion.
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- 2023
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199. Association of general anesthesia exposure with risk of postoperative delirium in patients receiving transcatheter aortic valve replacement: a meta-analysis and systematic review
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Ching-Chung Ko, Kuo-Chuan Hung, Yang-Pei Chang, Chien-Cheng Liu, Wan-Jung Cheng, Jheng-Yan Wu, Yu-Yu Li, Tso-Chou Lin, and Cheuk-Kwan Sun
- Subjects
Medicine ,Science - Abstract
Abstract The aim of this meta-analysis was to assess the association of general anesthesia (GA) exposure with the risk of POD in this patient population. Databases including Medline, EMBASE, Cochrane library, and Google Scholar were searched from inception to December 2022. Analysis of 17 studies published between 2015 and 2021 involving 10,678 individuals revealed an association of GA exposure with an elevated risk of POD [odd ratio (OR) = 1.846, 95% CI 1.329 to 2.563, p = 0.0003, I2 = 68.4%, 10,678 patients]. Subgroup analysis of the diagnostic methods also demonstrated a positive correlation between GA exposure and POD risk when validated methods were used for POD diagnosis (OR = 2.199, 95% CI 1.46 to 3.31, p = 0.0002). Meta-regression analyses showed no significant impact of age, male proportion, and sample size on the correlation between GA and the risk of POD. The reported overall incidence of POD from the included studies regardless of the type of anesthesia was between 0.8 and 27%. Our meta-analysis showed a pooled incidence of 10.3% (95% CI 7% to 15%). This meta-analysis suggested an association of general anesthesia with an elevated risk of postoperative delirium, implying the necessity of implementing appropriate prophylactic strategies against this complication when general anesthesia was used in this clinical setting.
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- 2023
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200. Pretreatment 18F‐FDG uptake heterogeneity may predict treatment outcome of combined Trastuzumab and Pertuzumab therapy in patients with metastatic HER2 positive breast cancer
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Guang Ma, Shuhui You, Yizhao Xie, Bingxin Gu, Cheng Liu, Xichun Hu, Shaoli Song, Biyun wang, and Zhongyi Yang
- Subjects
Heterogeneity of 18F-FDG uptake ,Prognosis ,Metastatic HER2 positive breast cancer ,Dual target therapy ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Objective Intra-tumoral heterogeneity of 18F‐fluorodeoxyglucose (18F‐FDG) uptake has been proven to be a surrogate marker for predicting treatment outcome in various tumors. However, the value of intra-tumoral heterogeneity in metastatic Human epidermal growth factor receptor 2(HER2) positive breast cancer (MHBC) remains unknown. The aim of this study was to evaluate 18F‐FDG uptake heterogeneity to predict the treatment outcome of the dual target therapy with Trastuzumab and Pertuzumab(TP) in MHBC. Methods Thirty-two patients with MHBC who underwent 18F-FDG positron emission tomography/computed tomography (PET/CT) scan before TP were enrolled retrospectively. The region of interesting (ROI) of the lesions were drawn, and maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), total lesion glycolysis (TLG), metabolic tumor volume (MTV) and heterogeneity index (HI) were recorded. Correlation between PET/CT parameters and the treatment outcome was analyzed by Spearman Rank Test. The ability to predict prognosis were determined by time‐dependent survival receiver operating characteristic (ROC) analysis. And the survival analyses were then estimated by Kaplan‐Meier method and compared by log‐rank test. Results The survival analysis showed that HI50% calculated by delineating the lesion with 50%SUVmax as threshold was a significant predictor of patients with MHBC treated by the treatment with TP. Patients with HI50% (≥ 1.571) had a significantly worse prognosis of progression free survival (PFS) (6.87 vs. Not Reach, p = 0.001). The area under curve (AUC), the sensitivity and the specificity were 0.88, 100% and 63.6% for PFS, respectively. Conclusion 18F-FDG uptake heterogeneity may be useful for predicting the prognosis of MHBC patients treated by TP.
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- 2023
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