Author: "Del Prato, S." - Searchworks@Jio Institute Digital Library Search Results

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1,283 results on '"Del Prato, S."'

151. Subcutaneous insulin infusion (CSII) in italy: The third national survey

Author: Bruttomesso, D., Laviola, L., Lepore, G., Bonfanti, R., Bozzetto, L., Corsi, A., Di Blasi, V., Girelli, A., Grassi, G., Iafusco, D., Rabbone, I., Schiaffini, R., Montani, V., Colleluori, P., Paciotti, V., Alfidi, P., Grosso, J., Tumini, S., Cipriano, P., Vitacolonna, E., Di Vieste, G., Minnucci, A., Antenucci, D., La Penna, G., Taraborrelli, M., Macerala, B., Citro, G., De Morelli, G., Gnasso, A., Irace, C., Citriniti, F., Lazzaro, N., Bruzzese, M., Mammi, F., De Berardinis, F., Santoro, E., Corigliano, G., Corigliano, M., Parillo, M., Schettino, M., Fresa, R., Annuzzi, G., Bassi, V., Santinelli, C., Buono, P., Mozzillo, E., Russo, V., De Feo, E., Esposito, K., Petrizzo, M., Foglia, A., Gatti, A., Gentile, S., Guarino, G., Zanfardino, A., Lambiase, C., Vitale, A., Zucchini, S., Maltoni, G., Forlani, G., Moscatiello, S., Suprani, T., Bensa, M., Tomasi, F., Monesi, M., Nizzoli, M., Acquati, S., Chierici, G., Milli, B., Iughetti, L., Predieri, B., Cavani, R., Romano, S., Manicardi, V., Michelini, M., Cimicchi, M. C., Ugolotti, D., Zavaroni, I., Dei Cas, A., Dall'Aglio, E., Papi, M., Tardio, S. M., Calderini, M. C., Riboni, S., D'Amato, L., Zavaroni, D., Gastaldi, L., Cirillo, A., Di Bartolo, P., Pellicano, F., Di Secli, C., Amarri, S., Lasagni, A., Marsciani, A., Pedini, A., Pagliani, U., Rossi, C., Tortul, C., Brunato, B., Assaloni, R., Zanette, G., Livolsi, P., Petrucco, A., Tercelj, K., Manca, E., Candido, R., Tommasi, E., Tornese, G., Faleschini, E., Tonutti, L., Agus, S., Zanatta, M., Rosolen, A., Comici, A., Falasca, P., Graziano, F. M., Misischi, I., Forte, E., Palmacci, C., Tuccinardi, F., Ricciardi, G. P., Di Masa, P., Ragonese, M., Cipolloni, L., Buzzetti, R., Moretti, C., Leto, G., Crino, A., Bocchini, S., Pozzilli, P., Maurizi, A. R., Di Perna, P., Giuliano, M., Frontoni, S., Malandrucco, I., Pitocco, D., Scalpone, R., Toscanella, F., Cappa, M., Ventura, C., Bonato, V., De Bernardinis, M., Cavallo, M. G., Leonetti, F., Morano, S., Mandosi, E., Cicconetti, E., Ciampittiello, G., Marini, M. A., Sabato, D., Lauro, D., Napoli, A., Giraudo, F., Toscano, V., Pugliese, G., Massimiani, F., Fava, D., Gargiulo, P., Mecca, N., Tubili, C., Nardone, M. R., Morviducci, L., Manca-Bitti, M. L., Arcano, S., Leotta, S., Suraci, C., Chiaramonte, F., Visalli, N., Strollo, F., Arnaldi, C., Tosini, D., Ponzani, P., Patrone, M., Guido, R., Aglialoro, A., Ghisoni, G., Fabbri, F., Bordone, C., Maggi, D., Cordera, R., Minuto, N., Rotondo, E., Speranza, D., Siri, M., Carro, S., Zappa, A., Parmigiani, S., Nieri, S., Briatore, L., Calvo, G., Querci, F., Trevisan, R., Bonfadini, S., Prandi, E., Felappi, B., Locatelli, F., Fuso, V., Rocca, A., Meneghini, E., Massafra, C., Terni, T., Elli, P., Ruggeri, P., Carrai, E., Musacchio, N., Marelli, G., Vilei, V., Richini, D., Inversini, C., Franzetti, I., Bonacina, M., Ciucci, A., Sciangula, L., Duratorre, E., Bonomo, M., Bertuzzi, F., Chebat, E., Muratori, M., Scaramuzza, A., Zuccotti, G. V., Bollati, P. M., Colapinto, P., Orsi, E., Palmieri, E., Laurenzi, A., Molinari, C., Frontino, G., Veronelli, A., Zecchini, B., Bianchi, A., Torchio, G., Lovati, E., Ghilardi, G., Dagani, R., Berra, C., Fochesato, E., Pissarelli, A., Bucciarelli, L., Bulgheroni, M., Guerraggio, L., Zonca, S., Bossi, A. C., Berzi, D., Mangone, I., Cazzaniga, E., Rabini, R. A., Boemi, M., Faloia, E., Boscaro, M., Sternari, G., Iannilli, A., Cherubini, V., Tinti, G., Manfrini, S., Tesei, A. M., Maolo, G., Galetta, M., Vespasiani, G., Busciantella Ricci, N., Cartechini, M. G., Aiello, A., Di Vincenzo, S., Vitale, C., Di Caro, P., Lera, R., Secco, A., Lesina, A., Romeo, F., Origlia, C., Giorda, C., Chiambretti, A. M., Fornengo, R., De Donno, V., Gallarotti, F., Manti, R., Marafetti, L., Cadario, F., Savastio, S., Barbieri, P., Massucco, P., Ali, A., Gottero, C., Degiovanni, M., Bertaina, S., Maghenzani, G., Tinti, D., Fontana, F., Giorgino, F., Stefanelli, G., Cavallo, L., Zecchino, C., Piccinno, E., Ortolani, F., Gallo, F., Moramarco, F., Marino, A., Sparasci, G., Mileti, G., Lamacchia, O., Picca, G., Coccioli, M. S., Micale, F., Serra, R., Romano, I., Savino, T., Giovanni, S., De Cosmo, S., Rauseo, A., Delvecchio, M., Lapolla, R., Braione, A. F., Papagno, G., Baroni, M., Melis, M., Cossu, E., Songini, M., Cambuli, V. M., Lo Presti, D., Timpanaro, T. A., Chiavetta, A., Garofalo, M. R., Tommaselli, L., Tumminia, A., Scarpitta, A. M., Di Benedetto, A., Giunta, L., Lombardo, F., Salzano, G., Cardella, F., Roppolo, R., Provenzano, V., Fleres, M., Migliorini, S., De Luca, A., Leopardi, A., Beltrami, C., Toni, S., Guasti, G., Lenzi, L., Lamanna, C., Mannucci, E., Lucchesi, S., Di Cianni, G., Aragona, M., Del Prato, S., Fattor, B., Eisath, J., Pasquino, B., Reinstadler, P., Kaufmann, P., Incelli, G., Rauch, S., Romanelli, T., Cauvin, V., Franceschi, R., Ospedale, S. C., Soldani, C., Scattoni, R., Norgiolini, R., Celleno, R., Torlone, E., Bolli, G. B., Lalli, C., Scarponi, M., Bobbio, A., Bechaz, M., Pianta, A., Marangoni, A., Arico, C. N., Alagona, C., Confortin, L., Rossi, E., Boscolo, B. A., Nogara, A., Bettio, M., Frison, V., Guidoni, G. L., Fongher, C., Contin, M. L., Cosma, A., Vianello, S., Bondesan, L., Morea, A., Volpi, A., Coracina, A., Panebianco, G., Lombardi, S., Costa, S., Cipponeri, E., Vedovato, M., Scotton, R., Monciotti, C. M., Galderisi, A., Dalfra, M. G., Lapolla, A., Portogruaro, S., Zanon, M., Lisato, G., Mollo, F., Calcaterra, F., Miola, M., Paccagnella, A., Sambataro, M., Moro, E., Trombetta, M., Negri, C., Sabbion, A., Maffeis, C., Strazzabosco, M., Mesturino, C. A., and Mingardi, R.
Subjects: Diabetes mellitus, Continuous subcutaneous insulin infusion, Insulin pump
Published: 2015

152. Lower fasting blood glucose, glucose variability and nocturnal hypoglycaemia with glargine vs NPH basal insulin in subjects with Type 1 diabetes

Author: Bolli, G, Songini, M, Trovati, M, Del Prato, S, Ghirlanda, G, Cordera, R, Trevisan, R, Riccardi, G, Noacco, C, Bolli GB, Songini M, Trovati M, Del Prato S, Ghirlanda G, Cordera R, Trevisan R, Riccardi G, Noacco C, Bolli, G, Songini, M, Trovati, M, Del Prato, S, Ghirlanda, G, Cordera, R, Trevisan, R, Riccardi, G, Noacco, C, Bolli GB, Songini M, Trovati M, Del Prato S, Ghirlanda G, Cordera R, Trevisan R, Riccardi G, and Noacco C
Abstract: Background and aims: To compare switching from NPH insulin (NPH) to insulin glargine (glargine) with continuing NPH for changes in fasting blood glucose (FBG) in patients with Type 1 diabetes on basal-bolus therapy with insulin lispro as bolus insulin. Secondary objectives included self-monitoring blood glucose, mean daily blood glucose (MDBG) and mean amplitude glucose excursion (MAGE) values alongside changes in HbA1c and safety profiles. Methods and results: This was a 30-week, parallel, open-label, multicentre study. Seven-point profiles were used to calculate MDBG and MAGE. Hypoglycaemia and adverse events were recorded by participants. FBG improved significantly with both glargine (baseline-endpoint change: -28.0 mg/dL; 95% CI: -37.3, -18.7 mg/dL; p < 0.001) and NPH (-9.8 mg/dL; 95% CI: -19.1, -0.5 mg/dL; p = 0.0374). The improvement was significantly greater with glargine than NPH (mean difference: -18.2 mg/dL; 95% CI: -31.3, -5.2 mg/dL; p = 0.0064). MDBG (-10.1 mg/dL; 95% CI: -18.1, -2.1 mg/dL; p = 0.0126) and MAGE (-20.0 mg/dL; 95% CI: -34.5, -5.9 mg/dL; p = 0.0056) decreased significantly with glargine, but not NPH although endpoint values were no different with the two insulins. Baseline to endpoint change in HbA1c was similar (-0.56 vs -0.56%) with no differences at endpoint. Overall hypoglycaemia was no different, but glargine reduced nocturnal hypoglycaemia ("serious episodes" with BG < 42 mg/dl, p = 0.006) whereas NPH did not (p = 0.123), although endpoint values were no different. Conclusion: Switching from NPH to glargine is well tolerated and results into lower FBG, and lower glucose variability while reducing nocturnal hypoglycaemia. These data provide a rationale for more aggressive titration to target with glargine in Type 1 diabetes.
Published: 2009

153. Telecare Provides comparable efficacy to conventional self-monitored blood glucose in patients with type 2 diabetes titrating one injection of insulin glulisine-the ELEONOR study

Author: Del Prato S, Nicolucci A, Eleonor, Study Group, CAPALDO, BRUNELLA, Del Prato S, Nicolucci A, Eleonor, Study Group, and Capaldo, Brunella
Subjects: telecare, type 2 diabetes, self-monitoring blood glucose
Published: 2012

154. Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone: impact on cardiovascular events. A randomized controlled trial

Author: Vaccaro, O, Masulli, M, Bonora, E, Del Prato, S, Giorda, Cb, Maggioni, Ap, Mocarelli, P, Nicolucci, A, Rivellese, Aa, Squatrito, S, Riccardi, G, IT study group, T. O. S. C. A., Sud, Cm, Imbaro, S, Garofalo, N, Ferrannini, E, Howard, B, Gerdts, E, Imperatore, G, Tavazzi, L, Pellegrini, F, Fabbri, G, Levantesi, G, Turazza, F, Gentile, S, Panico, S, Brambilla, P, Signorini, S, Cappellini, F, Parma, C, D'Alonzo, D, Di Nardo, B, Ferrari, S, Franciosi, M, Pecce, R, Valentini, M, Ceseri, M, Bianchini, F, Baldini, E, Atzori, A, Boemi, M, D'Angelo, F, Giansanti, R, Ricci, L, Ranchelli, A, Di Berardino, P, Cannarsa, E, Giorgino, F, Manicone, M, Tarantino, L, Trevisan, R, Scaranna, C, Forlani, G, Montesi, L, Aiello, A, Barrea, A, Sinagra, T, Longhitano, S, Sesti, G, Gnasso, A, Carallo, C, Scicchitano, C, Santini, C, Calbucci, G, Ripani, R, Corsi, L, Corsi, S, Romeo, F, Asprino, V, Donnarumma, G, Tizio, B, Clemente, G, Tomasi, F, Dozio, N, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, Ol, Fariello, S, Cordera, R, Mazzucchelli, C, Pupillo, M, Zugaro, A, Bosco, A, De Luca, A, Iannarelli, R, Giuliani, A, Polidoro, L, Sperandio, A, Sciarretta, F, Raffaella, B, Venditti, C, Di Cianni, G, Goretti, C, Dolci, Ma, Bruselli, L, Mori, M, Baccetti, F, Gregori, G, Venezia, A, Cucinotta, D, Pintaudi, B, Ragonese, F, Pata, P, Piatti, Pm, Luccotti, P, Orsi, E, Bonomo, M, Menicatti, L, Turco, Aa, Ciano, O, Vallefuoco, P, Corigliano, G, Pentangelo, C, Petraroli, E, Auletta, P, Carbonara, O, Capobianco, G, Caiazzo, G, Angiulli, B, De Simone, G, Michele, C, Mastrilli, V, Nunziata, G, Romano, G, Gaeta, I, Sorrentino, T, Iovine, C, Nappi, F, Paolisso, G, Rizzo, Mr, Avogaro, A, Vedovato, M, Lapolla, A, Sartore, G, Burlina, S, Chilelli, Nc, Galluzzoy, A, Giordano, C, Torregrossa, V, Arsenio, L, Dall'Aglio, E, Cioni, F, Babini, M, Moncastroppa, G, Perriello, G, Timi, A, Consoli, A, Ginestra, F, Zavaroni, D, Calzoni, F, Miccoli, R, Bianchi, C, Politi, S, Anichini, R, Tedeschi, A, Citro, G, Zampino, A, Rosa, S, Natale, M, Giocoli, Cl, Caruso, E, Tramontano, L, Imbroinise, A, Perna, Cd, Calabrese, M, Zogheri, A, Luberto, A, Ballardini, G, Babini, Ac, Zannoni, C, Pugliese, G, Salvi, L, Mazzitelli, G, Zappaterreno, A, Frontoni, S, Ventricini, A, Lauro, D, Galli, A, Rinaldi, Me, Leotta, S, Fontana, L, Goretti, S, Pozzilli, P, Leonetti, F, Morano, S, Filetti, S, Cosmo, Sd, Bacci, S, Palena, Ap, Calatola, P, Capuano, G, Amelia, U, Dotta, Francesco, Guarino, E, Ceccarelli, E, Lalli, C, Scarponi, M, Forte, E, Potenziani, S, Perin, Pc, Marena, S, Zucco, C, Perotto, M, Bossi, A, Filopanti, M, Grimaldi, F, Tonutti, L, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Capra, C, Cigolini, M., Vaccaro, O1, Masulli, M, Bonora, E, Del Prato, S, Giorda, Cb, Maggioni, Ap, Mocarelli, P, Nicolucci, A, Rivellese, Aa, Squatrito, S, Riccardi, G, Collaborators Riccardi G, T. O. S. C. A. IT study g. r. o. u. p., Sud, Cm, Imbaro, S, Vaccaro, O, Garofalo, N, Ferrannini, E, Howard, B, Gerdts, E, Imperatore, G, Tavazzi, L, Pellegrini, F, Fabbri, G, Levantesi, G, Turazza, F, Gentile, Sandro, Panico, S, Brambilla, P, Signorini, S, Cappellini, F, Parma, C, D'Alonzo, D, Di Nardo, B, Ferrari, S, Franciosi, M, Pecce, R, Valentini, M, Ceseri, M, Bianchini, F, Baldini, E, Atzori, A, Boemi, M, D'Angelo, F, Giansanti, R, Ricci, L, Ranchelli, A, Di Berardino, P, Cannarsa, E, Giorgino, F, Manicone, M, Tarantino, L, Trevisan, R, Scaranna, C, Forlani, G, Montesi, L, Aiello, A, Barrea, A, Sinagra, T, Longhitano, S, Sesti, G, Gnasso, A, Carallo, C, Scicchitano, C, Santini, C, Calbucci, G, Ripani, R, Corsi, L, Corsi, S, Romeo, F, Asprino, V, Donnarumma, G, Tizio, B, Clemente, G, Tomasi, F, Dozio, N, Mannucci, E, Lamanna, C, Cignarelli, M, Macchia, Ol, Fariello, S, Cordera, R, Mazzucchelli, C, Pupillo, M, Zugaro, A, Bosco, A, De Luca, A, Iannarelli, R, Giuliani, A, Polidoro, L, Sperandio, A, Sciarretta, F, Raffaella, B, Venditti, C, Di Cianni, G, Goretti, C, Dolci, Ma, Bruselli, L, Mori, M, Baccetti, F, Gregori, G, Venezia, A, Cucinotta, D, Pintaudi, B, Ragonese, F, Pata, P, Piatti, Pm, Luccotti, P, Orsi, E, Bonomo, M, Menicatti, L, Turco, Aa, Ciano, O, Vallefuoco, P, Corigliano, G, Pentangelo, C, Petraroli, E, Auletta, P, Carbonara, O, Capobianco, G, Caiazzo, G, Angiulli, B, De Simone, G, Michele, C, Mastrilli, V, Nunziata, G, Romano, G, Gaeta, I, Sorrentino, T, Iovine, C, Nappi, F, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Avogaro, A, Vedovato, M, Lapolla, A, Sartore, G, Burlina, S, Chilelli, Nc, Galluzzoy, A, Giordano, C, Torregrossa, V, Arsenio, L, Dall'Aglio, E, Cioni, F, Babini, M, Moncastroppa, G, Perriello, G, Timi, A, Consoli, A, Ginestra, F, Zavaroni, D, Calzoni, F, Miccoli, R, Bianchi, C, Politi, S, Anichini, R, Tedeschi, A, Citro, G, Zampino, A, Rosa, S, Natale, M, Giocoli, Cl, Caruso, E, Tramontano, L, Imbroinise, A, Perna, Cd, Calabrese, M, Zogheri, A, Luberto, A, Ballardini, G, Babini, Ac, Zannoni, C, Pugliese, G, Salvi, L, Mazzitelli, G, Zappaterreno, A, Frontoni, S, Ventricini, A, Lauro, D, Galli, A, Rinaldi, Me, Leotta, S, Fontana, L, Goretti, S, Pozzilli, P, Leonetti, F, Morano, S, Filetti, S, Cosmo, Sd, Bacci, S, Palena, Ap, Calatola, P, Capuano, G, Amelia, U, Dotta, F, Guarino, E, Ceccarelli, E, Lalli, C, Scarponi, M, Forte, E, Potenziani, S, Perin, Pc, Marena, S, Zucco, C, Perotto, M, Bossi, A, Filopanti, M, Grimaldi, F, Tonutti, L, Cavarape, A, Cigolini, M, Pichiri, I, Brangani, C, Tomasetto, E, Capra, C, Cigolini M., Author information, Vaccaro, Olga, Masulli, Maria, Rivellese, ANGELA ALBAROSA, Riccardi, Gabriele, Giorda, C, Maggioni, A, Rivellese, A, Giorda, CB, Maggioni, AP, and Rivellese, AA
Subjects: Blood Glucose, Male, BIO/12 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA, Endocrinology, Diabetes and Metabolism, pioglitazone, sulfonylurea, type 2 diabetes, metformin, cardiovascular events, Medicine (miscellaneous), Type 2 diabetes, Settore MED/13 - Endocrinologia, Body Mass Index, law.invention, Randomized controlled trial, Risk Factors, law, Surveys and Questionnaires, Cardiovascular Disease, pioglitazone, piogllitazone, Stroke, Diabetes, Therapy, Pioglitazone, Nutrition and Dietetics, Diabetes, Thiazolidinedione, cardiovascular events, Type 2 Diabetes Mellitus, sulphonylureas, Middle Aged, Metformin, Sulfonylurea Compound, Treatment Outcome, Tolerability, Cardiovascular Diseases, Drug Therapy, Combination, Female, type 2 diabetes, Cardiology and Cardiovascular Medicine, Human, medicine.drug, medicine.medical_specialty, Endpoint Determination, sulfonylurea, cardiovascualr event, Sudden death, Follow-Up Studie, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, sulfonylureas, interventio trial, randomized controlled trial, Aged, Hypoglycemic Agent, Questionnaire, business.industry, Risk Factor, medicine.disease, Surgery, Sulfonylurea Compounds, Diabetes Mellitus, Type 2, Quality of Life, Thiazolidinediones, Therapy, business, metformin, Pioglitazone, Follow-Up Studies
Abstract: Background and aims Metformin is the first-line therapy in type 2 diabetes. In patients inadequately controlled with metformin, the addition of a sulfonylurea or pioglitazone are equally plausible options to improve glycemic control. However, these drugs have profound differences in their mechanism of action, side effects, and impact on cardiovascular risk factors. A formal comparison of these two therapies in terms of cardiovascular morbidity and mortality is lacking. The TOSCA.IT study was designed to explore the effects of adding pioglitazone or a sulfonylurea on cardiovascular events in type 2 diabetic patients inadequately controlled with metformin. Methods Multicentre, randomized, open label, parallel group trial of 48 month duration. Type 2 diabetic subjects, 50–75 years, BMI 20–45 Kg/m 2 , on secondary failure to metformin monotherapy will be randomized to add-on a sulfonylurea or pioglitazone. The primary efficacy outcome is a composite endpoint of all-cause mortality, nonfatal myocardial infarction, nonfatal stroke, and unplanned coronary revascularization. Principal secondary outcome is a composite ischemic endpoint of sudden death, fatal and non-fatal myocardial infarction and stroke, endovascular or surgical intervention on the coronary, leg or carotid arteries, major amputations. Side effects, quality of life and economic costs will also be evaluated. Efficacy, safety, tolerability, and study conduct will be monitored by an independent Data Safety Monitoring Board. End points will be adjudicated by an independent external committee. Conclusions TOSCA.IT is the first on-going study investigating the head-to-head comparison of adding a sulfonylurea or pioglitazone to existing metformin treatment in terms of hard cardiovascular outcomes. Registration: Clinicaltrials.gov ID NCT00700856.
Published: 2012

155. The 'TOSCA.IT' trial: a study designed to evaluate the effect of pioglitazone vs sulphonylureas on CVD in type 2 diabetes

Author: VACCARO, OLGA, MASULLI, MARIA, RIVELLESE, ANGELA ALBAROSA, Bonora E. Del Prato S. Nicolucci A., RICCARDI, GABRIELE, Vaccaro, Olga, Masulli, Maria, Bonora, E. Del Prato S. Nicolucci A., Rivellese, ANGELA ALBAROSA, and Riccardi, Gabriele
Subjects: intervention trial, cardiovascualr events, hypoglycemic treatment
Published: 2012

156. Optimizing insulin glargine plus one injection of insulin glulisine in type 2 diabetes in the ELEONOR study: similar effects of telecare and conventional self-monitoring of blood glucose on patient functional health status and treatment satisfaction

Author: Nicolucci, A, Del Prato, S, Vespasiani, G, DI MAURO, Maurizio, ELEONOR Study Group, Nicolucci, A, Del Prato, S, Vespasiani, G, Eleonor, Study Group, and Capaldo, Brunella
Subjects: telecare, insulin therapy, type 2 diabetes
Published: 2011

157. Cardiovascular prevention in subjects with impaired fasting glucose or impaired glucose tolerance

Author: Volpe, M, Borghi, C, Cavallo Perin, P, Chiariello, M, Manzato, E, Miccoli, R, Modena, Riccardi, G, Sesti, G, Tiengo, A, Trimarco, B, Vanuzzo, D, Verdecchia, P, Zaninelli, A, Del Prato, S, Volpe M, Borghi C, Cavallo Perin P, Chiariello M, manzato E, Miccoli R, Modena MG, Riccardi G, Sesti G, Tiengo A, Trimarco B, vannuzzo D, Verdecchia P, Zaninelli A, Del Prato S., Volpe, Massimo, Borghi, Claudio, Cavallo Perin, Paolo, Chiariello, Massimo, Manzato, Enzo, Miccoli, Roberto, Modena, Maria Grazia, Riccardi, Gabriele, Sesti, Giorgio, Tiengo, Antonio, Trimarco, Bruno, Vanuzzo, Diego, Verdecchia, Paolo, Zaninelli, Augusto, and Del Prato, Stefano
Subjects: medicine.medical_specialty, hypertension, Population, metabolic syndrome, Impaired glucose tolerance, impaired glucose tolerance insulin resistance abnormal glucose regulation metabolic syndrome diabetes mellitus hypertension cardiovascular prevention, insulin resistance, Epidemiology, medicine, Internal Medicine, Clinical significance, abnormal glucose regulation, cardiovascular prevention, diabetes mellitus, impaired glucose tolerance, Intensive care medicine, education, Socioeconomic status, education.field_of_study, business.industry, diabetes mellitu, Type 2 Diabetes Mellitus, medicine.disease, Impaired fasting glucose, Medical emergency, Metabolic syndrome, business, Cardiology and Cardiovascular Medicine
Abstract: Cardiovascular diseases still represent the leading cause of mortality and hospitalization, particularly in Western countries. As a consequence of the marked changes observed on the demographic characteristics of the general population, the improved survival rate after an acute cardiovascular event, and the progressive rise of costs (mostly due to technological and pharmacological innovations), the estimated burden of cardiovascular diseases will soon become insurmountable for national healthcare systems. In this view, an integrated approach aimed at improving strategies for cardiovascular disease prevention and, thus, limiting the negative outcomes, would probably be successful. Such an approach may not only achieve long-term benefits, but even significant advantages in the short to medium term, mostly in asymptomatic high-risk individuals. Indeed, this latter population of asymptomatic high-risk individuals would mostly benefit from extensive application and improvement of strategies for cardiovascular disease prevention with a favourable cost-benefit ratio. The Italian Society for Cardiovascular Disease Prevention — Società Italiana per la Prevenzione Cardiovascolare (SIPREC) — has recognized this strategic aim, focusing a vast majority of its institutional action on the effort for providing educational supports and consensus documents, which represent an overview of the scientific knowledge and personal clinical expertise by national and international key opinion leaders. Expert committees periodically generate ‘state-of-the-art’ documents on specific scientific topics with relevant socioeconomic implications and large clinical impact. The present article is dedicated to healthcare professionals, and is based on the available evidence, and provides useful information on diagnostic algorithms and therapeutic options. In 2006, the SIPREC Scientific Committee promoted a consensus document on the metabolic syndrome,[1] which is still widely used, frequently cited and updated, from which originated a broad educational programme throughout the Italian territory. This programme has certainly contributed to improving knowledge of a widespread clinical condition, such as the metabolic syndrome, which SIPREC interpreted not only as a theoretical pathophysiological concept or a nosographic entity, but rather as a real clinical tool for identifying and ‘intercepting’ those asymptomatic individuals at risk of cardiovascular events, before the estimated level of risk becomes high. This new article may be viewed in the same strategic line. The relationship between abnormalities in blood glucose metabolism (or dysglycaemia) and cardiovascular complications represents another important and relatively early target for cardiovascular disease prevention. SIPREC Scientific Committee identified even in this clinical setting an excellent group of scientific experts, in order to collect a multidisciplinary ‘task force’. This group has been asked to explain in a short, simple and effective fashion the epidemiological impact and the pathophysiological nature of the problem, its clinical features, potential diagnostic algorithms and therapeutic options, and its influence on the clinical practice of both specialist physicians and general practitioners. The work of this Task Force, which is reported in this article, is primarily a baseline for discussing novel future strategies for cardiovascular prevention. Also, this article is aimed at highlighting the importance of an emerging marker of cardiovascular risk, which is little recognized and often undervalued. Dysglycaemia, in turn, has a clinical significance, which is at least, in part, comparable with that of type 2 diabetes mellitus, both in terms of epidemiological prevalence and of long-term cardiovascular prognosis.
Published: 2010

158. Universal screening and intensive metabolic management of gestational diabetes: cost-effectiveness in Italy

Author: L Volpe, Antonio Boldrini, Luca Benzi, Di Cianni G, G Teti, Lorella Marselli, I Casadidio, Del Prato S, Bottone P, and Cristina Lencioni
Subjects: Adult, medicine.medical_specialty, endocrine system diseases, Cost effectiveness, Cost-Benefit Analysis, Endocrinology, Diabetes and Metabolism, Endocrinology, Pregnancy, Diabetes mellitus, Health care, Internal Medicine, medicine, Humans, Mass Screening, Mass screening, Retrospective Studies, business.industry, Obstetrics, Public health, nutritional and metabolic diseases, Retrospective cohort study, Health Care Costs, General Medicine, medicine.disease, female genital diseases and pregnancy complications, Surgery, Gestational diabetes, Diabetes, Gestational, Italy, Female, business
Abstract: This study retrospectively evaluated two groups of pregnant women. Group A women (n=1,338) were universally screened for gestational diabetes mellitus (GDM) and GDM patients were intensively treated. In Group B (n=4,035), screening was performed only in women at high risk for GDM and treatment was conventional. This study confirms the validity of a cost-effective screening program for the diagnosis of GDM and that selective screening may be an option only in a situation where healthcare resources are very scarce and/or universal screening of any kind is not feasible. Once the diagnosis of GDM has been made, metabolic management with an intensive approach is important to reduce maternal and fetal morbidity. Diagnosis of GDM and intensive treatment represent a cost for the public health system, but permit a significant monetary savings in terms of costs linked to maternal and neonatal morbidity.
Published: 2002

159. Successful Solitary Pancreas Transplantation With Portal-Enteric Drainage Following Unsuccessful Islet Cell Transplantation

Author: Boggi, U., Vistoli, F., Signori, S., Del Chiaro, M., Campatelli, A., Massa, M., Sgambelluri, F., Coppelli, A., Marchetti, P., Del Prato, S., and Mosca, F.
Published: 2005
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160. Il rischio residuo nelle dislipidemie: ruolo delle lipoproteine ad alta densità e dei trigliceridi plasmatici

Author: Bernini F, Brignoli O, Catapano AL, Chiarello M, Del Prato S, Fellin S, Gensini G, Iori I, Maggioni AP, Mancia G, Mannarino E, Mannucci PM, Mezzetti A, Salvatore N, Poli antonio, Ponroli A, Proto C, Volpe M, Zito G.B., BORGHI, CLAUDIO, Bernini F, Borghi C, Brignoli O, Catapano AL, Chiarello M, Del Prato S, Fellin S, Gensini G, Iori I, Maggioni AP, Mancia G, Mannarino E, Mannucci PM, Mezzetti A, Salvatore N, Poli antonio, Ponroli A, Proto C, Volpe M, and Zito GB.
Abstract: Ruolo dello stile di vita, lipoproteine ad alta densità nella prevenzione delle malattie cardiovascolari.
Published: 2009

161. Eterogeneità di malattia renale cronica (CKD) nel diabete mellito tipo 1 (DMT1)

Author: Russo, E, Penno, G, Garofolo, M, Lucchesi, D, Pucci, L, Sancho Bornez, V, Giusti, L, Bellante, R, Russo, R, Miccoli, R, and Del Prato, S.
Published: 2014

162. Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Author: Bonora, E., Capaldo, B., Perin, P. C., Del Prato, S., De Mattia, G., Frittitta, L., Frontoni, S., Leonetti, F., Luzi, L., Marchesini, G., Marini, M. A., Natali, A., Paolisso, G., Piatti, P. M., Pujia, A., Solini, A., Vettor, R., Bonadonna, R. C., Ferrannini, E., Baratta, R., Graci, S., Bracaglia, D., Monti, L., Setola, E., Montalcini, T., Sesti, G., De Kreutzenberg, S. V., E. Bonora, B. Capaldo, P. Cavallo Perin, S. Del Prato, G. De Mattia, L. Frittitta, S. Frontoni, F. Leonetti, L. Luzi, G. Marchesini Reggiani, M.A. Marini, A. Natali, G. Paolisso, P.M. Piatti, A .Pujia, A. Solini, R. Vettor, R.C. Bonadonna, Bonora, E, Capaldo, B, Perin, Pc, DEL PRATO, S, DE MATTIA, G, Frittitta, L, Frontoni, S, Leonetti, F, Luzi, L, Marchesini, G, Marini, Ma, Natali, A, Paolisso, Giuseppe, Piatti, Pm, Pujia, A, Solini, A, Vettor, R, Bonadonna, Rc, and GROUP OF ITALIAN SCIENTISTS OF INSULIN RESISTANCE, Gisir
Subjects: Adult, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Medicine (miscellaneous), Settore MED/13 - Endocrinologia, chemistry.chemical_compound, Insulin resistance, High-density lipoprotein, Internal medicine, Hyperinsulinism, Hyperinsulinemia, Medicine, Humans, Insulin, Hyperuricemia, Triglycerides, Aged, Aged, 80 and over, Nutrition and Dietetics, business.industry, Hypertriglyceridemia, Cholesterol, HDL, blood pressure, HDL-cholesterol, insulin, insulin resistance, triglycerides, uric acid, nutritional and metabolic diseases, Middle Aged, medicine.disease, Lipids, Endocrinology, Blood pressure, chemistry, Uric acid, Cardiology and Cardiovascular Medicine, business
Abstract: Backgound and Aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in nondiabetic subjects. Methods and Results: A database of hyperinsulinemic euglycemic clamp carried out with standard technique (40 mU per min per square meter of body surface area) in nondiabetic Italian subjects has been recently established. In this database we evaluated the relationships existing between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in nondiabetic subjects with fasting plasma glucose
Published: 2008

163. Efficacy and tolerability of rosuvastatin and atorvastatin when force-titrated in patient with primary hypercholesterolemia: results from the ECLIPSE study

Author: Faergman O, Hill L, Windler E, Wiklund O, Asmar R, Duffield E, Sosef F, McQueen M, Theroux P, LaHaye S, Hierlihy P, Kaiser S, Sussex B, Fortin C, Charles LJ, Gervais B, Richmond M, O'Keefe D, Grande P, Skagen K, Klarlund K, Dahlstrom CG, Gotzsche L, Westerbacka J, Pertti S, Forsen B, Lahti K, Honkavaara M, Savolainen P, Bjorkbom S, Miettinen P, Kaukoniemi E, Kaupinmaki E, Patala A, Strandberg A, Rytkonen R, Raisanen P, Tolvanen A, Strand J, Estour B, Duroy C, Nourry D, Galtier F, Lasfarques G, Gombaud D, Laurent P, Dimon B, Herlet L, Sarfati R, Garot A, Luccioni R, Rehn L, Freitag Hoppen J, Gendolla A, Schaefer A, Schax U, Schmeck J, Winter U, Hohenstatt T, Mauembaed R, Schell E, Klein C, Zimmermann U, Strotmann I, Colberg K, Ebert HH, Kosch C, Pfeiffer J, Lehmann R, Schulze ED, Gotze D, Pohl W, Boenninghoff EM, Faghih M, Elisaf M, Athyros V, Genovefa K, Richter D, Alexopoulos D, Krassas G, Toutouzas P, Kaldrimidis P, Del Prato S, Donadon W, Noacco C, Giorda CB, Comaschi M, Cimminiello C, Romeo F, Filetti S, Amoretti R, Di Pietro S, Rivellese A, Gentile S, Cignareli M, Formoso G, Albano S, Manai M, Borzì V, Fazio S, Leggio F, Cunha L, de Almeida AR, Mello e. Silva A, da Silva MM, Salgado AV, Barba S, Boavida J, Ulvenstam G, Teshale T, Bjuhr O, Lernfelt B, Carlsson T, Widen P, Kolmodin G, Blanberg A, Dahlen G, Zetterberg S, Beneus O, Kultursay H, Guneri S, Caglar N, Oktay A., CHIARIELLO, MASSIMO, Faergman, O, Hill, L, Windler, E, Wiklund, O, Asmar, R, Duffield, E, Sosef, F, Mcqueen, M, Theroux, P, Lahaye, S, Hierlihy, P, Kaiser, S, Sussex, B, Fortin, C, Charles, Lj, Gervais, B, Richmond, M, O'Keefe, D, Grande, P, Skagen, K, Klarlund, K, Dahlstrom, Cg, Gotzsche, L, Westerbacka, J, Pertti, S, Forsen, B, Lahti, K, Honkavaara, M, Savolainen, P, Bjorkbom, S, Miettinen, P, Kaukoniemi, E, Kaupinmaki, E, Patala, A, Strandberg, A, Rytkonen, R, Raisanen, P, Tolvanen, A, Strand, J, Estour, B, Duroy, C, Nourry, D, Galtier, F, Lasfarques, G, Gombaud, D, Laurent, P, Dimon, B, Herlet, L, Sarfati, R, Garot, A, Luccioni, R, Rehn, L, Freitag Hoppen, J, Gendolla, A, Schaefer, A, Schax, U, Schmeck, J, Winter, U, Hohenstatt, T, Mauembaed, R, Schell, E, Klein, C, Zimmermann, U, Strotmann, I, Colberg, K, Ebert, Hh, Kosch, C, Pfeiffer, J, Lehmann, R, Schulze, Ed, Gotze, D, Pohl, W, Boenninghoff, Em, Faghih, M, Elisaf, M, Athyros, V, Genovefa, K, Richter, D, Alexopoulos, D, Krassas, G, Toutouzas, P, Kaldrimidis, P, Del Prato, S, Donadon, W, Noacco, C, Giorda, Cb, Comaschi, M, Cimminiello, C, Romeo, F, Filetti, S, Amoretti, R, Di Pietro, S, Rivellese, A, Chiariello, Massimo, Gentile, S, Cignareli, M, Formoso, G, Albano, S, Manai, M, Borzì, V, Fazio, S, Leggio, F, Cunha, L, de Almeida, Ar, Mello e., Silva A, da Silva, Mm, Salgado, Av, Barba, S, Boavida, J, Ulvenstam, G, Teshale, T, Bjuhr, O, Lernfelt, B, Carlsson, T, Widen, P, Kolmodin, G, Blanberg, A, Dahlen, G, Zetterberg, S, Beneus, O, Kultursay, H, Guneri, S, Caglar, N, and Oktay, A.
Published: 2008

164. In situ Protein Kinase C activity is increased in cultured fibroblasts from Type 1 diabetic patients with nephropathy

Author: Lori, E, Marescotti, M, Vedovato, M, Ceolotto, G, Avogaro, A, Tiengo, A, Del Prato, S, Trevisan, R, Lori E, Marescotti MC, Vedovato M, Ceolotto G, Avogaro A, Tiengo A, Del Prato S, Trevisan R, Lori, E, Marescotti, M, Vedovato, M, Ceolotto, G, Avogaro, A, Tiengo, A, Del Prato, S, Trevisan, R, Lori E, Marescotti MC, Vedovato M, Ceolotto G, Avogaro A, Tiengo A, Del Prato S, and Trevisan R
Abstract: Aims/hypothesis. To verify whether individual susceptibility to diabetic nephropathy resides in an intrinsic difference in Protein Kinase C (PKC) activity. Methods. We compared the effect of different glucose concentrations on PKC activity, PKC isoform expression and diacylglycerol (DAG) content in cultured fibroblasts from 14 Type I diabetic patients who developed nephropathy with those in cells from 14 patients without nephropathy. We recruited 14 normal subjects as control patients. Forearm skin fibroblasts were cultured in either normal (5 mmol/l) or high (20 mmol/l) glucose concentrations. Results. In normal glucose, in situ PKC activity was higher in Type 1 patients with nephropathy (10.1 +/- 1.4 pmol/min/mg protein; p<0.01) than in those without (6.8 +/- 0.8) and the normal control subjects (6.3 +/- 0.5). This difference was due to increased concentrations of PKC(x isoform in the membrane fraction of fibroblasts from patients with nephropathy. DAG content was also higher in cells from Type 1 patients with nephropathy. Incubation in high glucose concentration caused a further increase in PKC activity and DAG content in quiescent fibroblasts from patients with diabetic nephropathy, with no significant changes in cells from diabetic patients without nephropathy and normal control subjects. Conclusion/interpretation. Differences in PKC activation could contribute to the individual susceptibility to renal damage in Type 1 diabetic patients.
Published: 2003

165. Correspondence between the International Diabetes Federation criteria for metabolic syndrome and insulin resistance in a cohort of Italian nondiabetic Caucasians: the GISIR database

Author: SESTI G, CAPALDO B, CAVALLO PERIN P, DEL PRATO S, FRITTITTA L, FRONTONI S, HRIBAL ML, MARCHESINI G, PIATTI PM, SOLINI A, BONORA E, GROUP OF, ITALIAN SCIENTISTS OF INSULIN RESISTANCE, PAOLISSO, Giuseppe, Sesti, G, Capaldo, Brunella, CAVALLO PERIN, P, DEL PRATO, S, Frittitta, L, Frontoni, S, Hribal, Ml, Marchesini, G, Paolisso, G, Piatti, Pm, Solini, A, Bonora, E, Group, Of, ITALIAN SCIENTISTS OF INSULIN, Resistance, Capaldo, B, and Paolisso, Giuseppe
Published: 2007

166. Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. The GISIR database

Author: Bonora E, Perin Cavallo P, Del Prato S, De Mattia G, Frittitta L, Frontoni S, Leonetti F, Marchesini G, Marini MA, Natali A, Prolisso G, Piatti PM, Pujia A, Solini A. Vettor R, Bonadonna RC, on behalf of the Group of Italian Scientists of Insulin R.e.s.i.s.t.a.n.c.e., CAPALDO, BRUNELLA, Bonora, E, Capaldo, Brunella, Perin Cavallo, P, Del Prato, S, De Mattia, G, Frittitta, L, Frontoni, S, Leonetti, F, Marchesini, G, Marini, Ma, Natali, A, Prolisso, G, Piatti, Pm, Pujia, A, Solini A., Vettor R, Bonadonna, Rc, and on behalf of the Group of Italian Scientists of Insulin, R. e. s. i. s. t. a. n. c. e.
Abstract: Background and aims: We evaluated whether hyperinsulinemia and/or insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in non-diabetic subjects. Methods and results: A database of non-diabetic Italian subjects has recently been set up using data from hyperinsulinemic euglycemic clamp studies carried out using the standard technique (40 mU per min per square meter of body surface area). In this database we evaluated the relationships between fasting plasma insulin (FPI), glucose metabolized during clamp (M) and plasma levels of triglycerides (TG), high density lipoprotein cholesterol (HDL-C), uric acid (UA) as well as blood pressure (BP) in non-diabetic subjects with fasting plasma glucose
Published: 2007

167. Concomitance of diabetic retinopathy and proteinuria accelerates the rate of decline of kidney function in type 2 diabetic patients

Author: Trevisan, R, Vedovato, M, Mazzon, C, Coracina, A, Iori, E, Tiengo, A, Del Prato, S, Trevisan R, Vedovato M, Mazzon C, Coracina A, Iori E, Tiengo A, Del Prato S, Trevisan, R, Vedovato, M, Mazzon, C, Coracina, A, Iori, E, Tiengo, A, Del Prato, S, Trevisan R, Vedovato M, Mazzon C, Coracina A, Iori E, Tiengo A, and Del Prato S
Abstract: OBJECTIVE - To evaluate the rate of progression of renal disease in proteinuric type 2 diabetic patients with and without retinopathy. RESEARCH DESIGN AND METHODS - Thirty-eight proteinuric type 2 diabetic patients with diabetic retinopathy and 27 without were enrolled in an observational study for the evaluation of rate of glomerular filtration rate (GFR) decline and followed up for a median period of 6 years. GFR was determined at least once per year, and blood pressure, glycated hemoglobin, and proteinuria were determined every 4 months. RESULTS - Although the two groups had comparable GFR, albuminuria, blood pressure, and HbA1c at entry of the study, the rate of decline of GFR was higher in type 2 diabetic patients with retinopathy (-6.5 ± 4.4 ml/year) than in those without (-1.8 ± 4.8 ml/year; P < 0.0001). Protein and albumin excretion rate increased significantly in patients with retinopathy, while they did not change in those without. Mean blood pressure between the two groups of patients were similar both at entry and during the follow-up, although the proportion of patients treated with at least two antihypertensive drugs was higher in patients with retinopathy. On a multiple regression analysis, only mean blood pressure and proteinuria were significant determinants of progression of renal disease in type 2 diabetic patients with retinopathy. CONCLUSIONS - The rate of progression of renal disease in proteinuric type 2 diabetic patients with retinopathy is faster than that observed in those without retinopathy. The screening for retinopathy identifies patients at high risk for rapid deterioration of kidney function.
Published: 2002

168. Efficacy and safety of linagliptin according to patient baseline characteristics: A pooled analysis of three phase 3 trials

Author: Del Prato, S., primary, Patel, S., additional, Crowe, S., additional, and von Eynatten, M., additional
Published: 2016
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169. Differential effects of once-weekly glucagon-like peptide-1 receptor agonist dulaglutide and metformin on pancreaticβ-cell and insulin sensitivity during a standardized test meal in patients with type 2 diabetes

Author: Mari, A., primary, Del Prato, S., additional, Ludvik, B., additional, Milicevic, Z., additional, de la Peña, A., additional, Shurzinske, L., additional, Karanikas, C. A., additional, and Pechtner, V., additional
Published: 2016
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170. Dipeptidyl peptidase-4 inhibition in chronic kidney disease and potential for protection against diabetes-related renal injury

Author: Penno, G., primary, Garofolo, M., additional, and Del Prato, S., additional
Published: 2016
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171. Comparison of alogliptin and glipizide for composite endpoint of glycated haemoglobin reduction, no hypoglycaemia and no weight gain in type 2 diabetes mellitus

Author: Del Prato, S., primary, Fleck, P., additional, Wilson, C., additional, and Chaudhari, P., additional
Published: 2016
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172. Pancreas transplant alone

Author: Marchetti, P., Boggi, U., Coppelli, A., Giannarelli, R., Vistoli, F., Aragona, M., Del Prato, S., and Mosca, F.
Published: 2004
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173. An alternative and simple method to consistently prepare viable isolated human islets for clinical transplantation

Author: Bugliani, M, Lupi, R, Del Guerra, S, Boggi, U, Marselli, L, Sbrana, S, Vistoli, F, Torri, S, Del Chiaro, M, Signori, S, Filipponi, F, Del Prato, S, Campa, M, Corsini, V, Campatelli, A, Di Candio, F, Mosca, F, and Marchetti, P
Published: 2004
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174. Kidney and pancreas transplants in Jehovah's witnesses: ethical and practical implications

Author: Boggi, U, Vistoli, F, Del Chiaro, M, Croce, C, Signori, S, Marchetti, P, Del Prato, S, Rizzo, G, and Mosca, F
Published: 2004
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175. Rationale, design, and baseline characteristics in Evaluation of LIXisenatide in Acute Coronary Syndrome, a long-term cardiovascular end point trial of lixisenatide versus placebo

Author: UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, Bentley-Lewis, R., Aguilar, D., Riddle, M.C., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H.C., Johnston, P., Køber, L.V., Lawson, F., Lewis, E.F., Maggioni, A.P., McMurray, J.J.V., Ping, L., Probstfield, J.L., Solomon, S.D., Tardif, J.-C., Wu, Y., Pfeffer, M.A., Barkoudah, E., Brahimi, A., Charytan, D., Finn, P., Flynn, A., Hartley, L.H., Henderson, G., Joseph, J., Odutayo, K., Rajesh, V., Vazir, A., Weinrauch, L., Del Prato, S., Petrie, J., Kaplan, A., Lieberman, P., Zuraw, B.L., O'Reilly, E., Patel, K., Allen, P., Scarpa, A., Schattner, M., Granger, C., Rouleau, J., DeMets, D., Chaturvedi, N., Raccah, D., Aizenberg, D., Alvarez, C., Alvarisqueta, A., Baccaro, C., Bartolacci, I., Bordonava, A., Bustamante Labarta, M., Caccavo, A., Calella, P., Cantero, M., Codutti, R., Commendatore, V., Costamagna, O., Cuello, J., Fernandez, A., Garcia Duran, R., Gomez Vilamajo, O., Gorban De Lapertosa, S., Grinfeld, D., Hermida, S., Lagrutta, M., Leon De La Fuente, R., Licheri, A., Luciardi, H., Mackinnon, I., Maffei, L., Marino, J., Montaña, O., Novaretto, L., Orio, S., Orlandini, A., Oviedo, A., Pérez Manghi, F., Patocchi, C., Ramos, H., Rolandi, F., Saa Zarandon, R., Saavedra, S.S., Schiavi, L., Schygiel, P., Trivi, M., Ulla, M., Urdiales, P., Vallejos, J., Vico, M., Waisman, F., Amerena, J., Paul, V., Sangla, K., Van Gaal, W., Yeap, B., Fasching, P., Pieber, T., Danilova, L., Mitkovskaya, N., Sudzhaeva, S., Mathieu, C., Pouleur, Anne-Catherine, Botelho, R.V., Cerqueira, M.J., Chacra, A., Dos Santos, F., Feitosa, G., Forti, A., Golbert, M., Halpern, A., Hissa, M., Lisboa, H., Moraes, J., Nery, M., Quadros, A., Raduan, R., Reis, G., Ribeiro Filho, F., Rollin, G., Rossi, P., Santos, E., Sgarbi, J., Souza, J., Souza, M.R., Delchev, A., Ivanov, V., Klyuchkova, N., Kyoleyan, M., Levterov, G., Lucheva, M., Raev, D., Shumkova, R., Tokmakova, M., Tzekova, M., Yordanov, V., Bailey, G., Bertrand, O., Bhargava, R., Burton, J., Campeau, J., Dumas, R., Filteau, P., Syan, G., Syan, R., Tsoukas, G., Warnica, J.W., Acuña, S., Araneda, G., Bunster, L., Cobos, L., Corbalán, R., Dussaillant, G., Eggers, G., Florenzano, F., Godoy, G., Huidobro, L.A., Lahsen, R., Lanas, F., Larenas, G., Manriquez, L., Medina, M., Palma, J.C., Perez, L., Potthoff, S., Raffo, C., Reyes, E., Saavedra, V., Sanhueza, P., Sepulveda, P., Solis, C.L., Soto, N., Torres, C., Westerberg, B., Yañez, M., Chen, L., Dong, Y., Du, J., Guo, X., Han, P., Hu, T., Jiang, B., Ke, Y., Li, Z., Lu, J., Ma, C., Peng, Y., Shi, Y., Su, G., Tang, B., Xu, B., Yang, J., Yang, Y., Accini, J.L., Arteaga, J.M., Botero, R., Castillo, G., Coronel, J., Cure, C., Garcia, H., Garcia, L., Gomez, C., Hernandez Triana, E., Hernandez, H., Lopez, M., Lopez, P., Manzur, F., Molina, D., Rodriguez, J., Sanchez Vallejo, G., Yupanqui, H., Bronnum-Schou, J., Kaiser Nielsen, P., Nielsen, H., Rønne, H., Rasmussen, S., Rungby, J., Skagen, K., Thomsen, K.K., Torp-Pedersen, C., Duarte-Vera, Y., Marmol Alvear, R., Peñaherrera-Patiño, C., Assaad, S., Shelbaya, S., Ambos, A., Jakovlev, U., Lubi, M., Märtsin, K., Rosenthal, S., Vides, H., Alanko, J., Korsoff, P., Koski, A.-M., Lahtela, J., Nelimarkka, L., Tuomilehto, J., Cariou, B., Catargi, B., Ducloux, R., Hadjadj, S., Kerlan, V., Malecot, J.-M., Petit, C., Rodier, M., Chumburidze, V., Glonti, S., Lominadze, Z., Todua, F., Contzen, C., Marck, C., Fischer, H., Hagenow, A., Himpel-Bönninghoff, A., Kihm, L., Killat, H., Kleinertz, K., Kosch, C., Kreutzmann, K., Lappo, M., Mertes, B., Piechatzek, R., Prohaska, M., Rinke, A., Schellenberg, D., Toursarkissian, N., Arango, J., Gonzalez, R., Granados, A., Herrera, M., Montenegro, P., Munoz, R., Rodriguez, E., Turcios, E., Villalobos, R., Wyss, F., Hatterjee, S., Chopda, M., Chopra, V., Deshpande, N., Dutta, R., Dwivedi, S., Gandhi, P., Gupta, S.K., Gupta, J.B., Gupta, S., Hiregouder, N., Jha, S., Joshi, A., Khan, N., Kumbla, M., Magdum, M., Murthy, K., Prabhu, M., Sahay, R., Sethuraman, S., Shah, N., Shamanna, P., Singh, K.S., Singh, P., Somasekharan, A., Sreenivasamurthy, L., Supe, P., Adawi, F., Atar, S., Cohen, O., Efrati, S., Karnieli, E., Klainman, E., Minuchin, O., Mosenzon, O., Stern, N., Turgeman, Y., Wainstein, J., Aimaretti, G., Berra, C., Ciardullo, A.V., Consoli, A., Cucinotta, D., Di Marco, S., Giorda, C., Giordano, C., Mannucci, E., Orsi, E., Piatti, P., Pontiroli, A., Ponzani, P., Pozzilli, P., Rivellese, A., Akahori, H., Eki, Y., Fujii, K., Hata, Y., Himeno, H., Hirayama, A., Kishimoto, I., Kobayashi, Y., Miyaoka, H., Niiya, T., Nishi, Y., Nozaki, A., Nunohiro, T., Saito, T., Satoh, Y., Takahashi, A., Takahashi, J., Takase, H., Takase, S., Tsuboko, Y., Tsujimoto, M., Tsujino, M., Tsuzuki, M., Watanabe, S., Yamada, T., Chung, W.J., Rim, S., Jang, H., Kim, U., Chung, C.H., Shin, S.-H., Kim, K., Kim, J., Rha, S., Lee, N.H., Kim, C.-J., Park, K.S., Amolina, I., Ducena, K., Helda, R., Konrade, I., Pirags, V., Sime, I., Sokolova, J., Kakariekiene, V., Kavaliauskiene, R., Petrulioniene, Z., Sakalyte, G., Urboniene, A., Zarankiene, R., Uribe, M., Garcia-Hernandez, P., Garza, J., Vazquez-Garcia, A., Gonzalez, J.G., Escalante, M., Zavala, A., Bayram, E., Hernandez-Muñuzuri, J., Ramos, Lopez, G.A., Lujan, J., Garcia-Soria, M., Velasco-Sanchez, R., Rodriguez, I., Jimenez, S., Galeana, C., Lara, S., Garcia-Castillo, A., Castro, M.G., Aguilar-Orozco, R., Lopez Rosas, E., Vidrio, M., Llamas, G., Stobschinski De Alba, C.A., Carranza-Madrigal, J., Cardosa-Torres, F., Cornel, J.H., Dekkers, P., Frederiks, J., Hermans, W., Lok, D., Meeder, J., Nierop, P., Cooper, J., Lappegård, K.T., Nedrebø, B.G., Castro, E., Gonzalez Castillo, B., Gonzalez, E., Nieto Ortega, R., Andrade, M., Calderon, J., Chavez, C., Correa Flores, R.M., Farfan, J., Lu, L., Luque, E., Manrique, H., Mogrovejo, W., Pariona-Javier, M., Pinto, M., Roldan, Y., Zubiate, C., Dans, A., Gomez, M.H., Panelo, A., Rey, N., Sulit, D.J., Sy, R.A., 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S., Mariash, C., Martin, P., Mathew, J., May, M., Mayfield, R., McCall, A., Mcdaniel, C., Mcgrew, F., Mckenzie, M., Mefford, I., Mehta, A., Mikdadi, G., Mikhail, M., Monchamp, T., Moore, C., Moran, M., Morrar, N., Mosley, J., Mulford, M., Murray, J., Nakhle, S., Nallasivan, M., Odio, A., Oh, C., Olelewe, S., Palchick, B., Paliwal, Y., Papademetriou, V., Parikh, N., Patel, S., Phillips, L., Pitts, T., Prieto, F., Puttnam, R., Quyyumi, A., Randhawa, P., Rendell, M., Rhie, F., Roberts, J., Robinson, J., Robinson, M., Rubino, J., Ryan, E., Saathoff, S., Sachmechi, I., Saifi, A., Salacata, A., Sanders, R., Sanson, J., Savin, V., Schabauer, A., Schmedtje, J., Schwartz, A., Scott, C., Selagamsetty, M., Shannon, M., Shaw, S., Singal, D., Sjoberg, R., Smith, K., Sofley, C., Sonn, A., Sorof, S., Soroka, E., Spellman, C.W., Steinhoff, J., Suresh, D., Tahir, M., Tanenberg, R., Thawani, H., Thomson, S., Thrasher, J., Trachtenbarg, D., Trotta, M., Tuan, W., Twahirwa, M., Umpierrez, G., Vaid, B., Vance, C., Wang, T., Warner, A., Watson, H., Weber, S., Webster, B., Weindorff, K., Welch, M., Welker, J., White, A., White, L., Williams, M., Wu, W.-C., Wynne, A., Yocono, M., and Yuen, K.
Abstract: Background: Cardiovascular (CV) disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Furthermore, patients with T2DM and acute coronary syndrome (ACS) have a particularly high risk of CV events. The glucagonlike peptide 1 receptor agonist, lixisenatide, improves glycemia, but its effects on CV events have not been thoroughly evaluated. Methods: ELIXA (www.clinicaltrials.gov no. NCT01147250) is a randomized, double-blind, placebo-controlled, parallelgroup, multicenter study of lixisenatide in patients with T2DM and a recent ACS event. The primary aim is to evaluate the effects of lixisenatide on CV morbidity and mortality in a population at high CV risk. The primary efficacy end point is a composite of time to CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. Data are systematically collected for safety outcomes, including hypoglycemia, pancreatitis, and malignancy. Results: Enrollment began in July 2010 and ended in August 2013; 6,068 patients from 49 countries were randomized. Of these, 69% are men and 75% are white; at baseline, the mean ± SD age was 60.3 ± 9.7 years, body mass index was 30.2 ± 5.7 kg/m2, and duration of T2DM was 9.3±8.2 years. The qualifying ACS wasamyocardial infarctionin83% and unstableangina in 17%. The study will continue until the positive adjudication of the protocol-specified number of primary CV events. Conclusion: ELIXA will be the first trial to report the safety and efficacy of a glucagon-like peptide 1 receptor agonist in people with T2DM and high CV event risk. © 2015 Elsevier Inc. All rights reserved.
Published: 2015

176. Hyperalaninaemia is an early feature of diabetes secondary to total pancreatectomy

Author: Del Prato, S., Vigili de Kreutzenberg, S., Trevisan, R., Duner, E., Avogaro, A., Nosadini, R., Baccaglini, U., Tremolada, C., and Tiengo, A.
Published: 1985
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177. Effect of insulin replacement on intermediary metabolism in diabetes secondary to pancreatectomy

Author: Del Prato, S., Tiengo, A., Baccaglini, U., Tremolada, C., Duner, E., Marescotti, M. C., Avogaro, A., Valverde, I., Nosadini, R., and Assan, R.
Published: 1983
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178. Effect of streptozotocin in a case of glucagon-secreting malignant islets-cell tumor

Author: Del Prato, S., Rovira, A., Tessari, P., Avogaro, A., Nosadini, R., Valverde, I., Trevisan, R., and Tiengo, A.
Published: 1984
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179. Insulin receptors on circulating blood cells from patients with pancreatogenic diabetes: a comparison with type I diabetes and normal subjects

Author: Muggeo, M., Moghetti, P., Faronato, P. P., Valerio, A., Tiengo, A., Del Prato, S., and Nosadini, R.
Published: 1987
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180. Heterogeneity of chronic kidney disease (CKD) phenothypes in patients with type 1 diabetes mellitus

Author: Russo, E., Penno, G., Garofolo, M., Lucchesi, D., Pucci, L., Sancho Bornez, V., Russo, R., Giusti, L., Miccoli, R., and Del Prato, S.
Published: 2013

181. Influence of HDL cholesterol levels on endothelial progenitor cells function in patients with type 2 diabetes mellitus

Author: Lucchesi, D., Popa, S. G., Sancho Bornez, V., Pucci, L., Russo, E., Garofolo, M., Russo, R., Dardano, A., Giusti, L., Miccoli, R., Penno, G., Del Prato, S., and Mota, M.
Published: 2013

182. Personalized Management of Hyperglycemia in Type 2 Diabetes: Reflections from a Diabetes Care Editors' Expert Forum

Author: Home, P. D., DeFronzo, R., Chan, J. C. N., Buse, J. B., Cefalu, W. T., Leiter, L. A., LeRoith, D., Inzucchi, S. E., Raz, I., Del Prato, S., Rosenstock, J., Ferrannini, E., and Riddle, M. C.
Abstract: In June 2012, 13 thought leaders convened in a Diabetes Care Editors' Expert Forum to discuss the concept of personalized medicine in the wake of a recently published American Diabetes Association/European Association for the Study of Diabetes position statement calling for a patient-centered approach to hyperglycemia management in type 2 diabetes. This article, an outgrowth of that forum, offers a clinical translation of the underlying issues that need to be considered for effectively personalizing diabetes care. The medical management of type 2 diabetes has become increasingly complex, and its complications remain a great burden to individual patients and the larger society. The burgeoning armamentarium of pharmacological agents for hyperglycemia management should aid clinicians in providing early treatment to delay or prevent these complications. However, trial evidence is limited for the optimal use of these agents, especially in dual or triple combinations. In the distant future, genotyping and testing for metabolomic markers may help us to better phenotype patients and predict their responses to antihyperglycemic drugs. For now, a personalized ("n of 1") approach in which drugs are tested in a trial-and-error manner in each patient may be the most practical strategy for achieving therapeutic targets. Patient-centered care and standardized algorithmic management are conflicting approaches, but they can be made more compatible by recognizing instances in which personalized A1C targets are warranted and clinical circumstances that may call for comanagement by primary care and specialty clinicians.
Published: 2013
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183. Influence of severe obesity on circulating endothelial progenitor cells levels and effects of bariatric surgery

Author: Ciccarone, A., Lucchesi, D., Pucci, L., Bornez, V. Sancho, Russo, E., Garofolo, M., Bellante, R., Russo, R., Crisci, I., Simona Georgiana Popa, Giusti, L., Mota, M., Miccoli, R., Penno, G., and Del Prato, S.
Published: 2013

184. Effects of pioglitazone versus glyburide on endothelial function in type 2 diabetic patients with vascular complications: the SPLENDOR Study

Author: Garofolo, M., Pucci, L., Lucchesi, D., Bruno, R., Russo, E., Sancho Bornez, V., Russo, R., Giusti, L., Dardano, A., Avogaro, A., Ghiadoni, L., Miccoli, R., Di Pietro, C., Penno, G., and Del Prato, S.
Published: 2013

185. Enhanced responsiveness of blood pressure to sodium intake and to angiotensin II is associated with insulin resistance in IDDM patients with microalbuminuria

Author: Trevisan, R, Bruttomesso, D, Vedovato, M, Brocco, S, Pianta, A, Mazzon, C, Girardi, C, Jori, E, Semplicini, A, Tiengo, A, Del Prato, S, Trevisan R, Bruttomesso D, Vedovato M, Brocco S, Pianta A, Mazzon C, Girardi C, Jori E, Semplicini A, Tiengo A, Del Prato S, Trevisan, R, Bruttomesso, D, Vedovato, M, Brocco, S, Pianta, A, Mazzon, C, Girardi, C, Jori, E, Semplicini, A, Tiengo, A, Del Prato, S, Trevisan R, Bruttomesso D, Vedovato M, Brocco S, Pianta A, Mazzon C, Girardi C, Jori E, Semplicini A, Tiengo A, and Del Prato S
Abstract: We assessed blood pressure (BP), body weight, renal hemodynamics, and insulin sensitivity (by euglycemic-hyperinsulinemic clamp) in nine normoalbuminuric and seven microalbuminuric IDDM patients after 6 days on a low-sodium diet (20 mEq) and after 6 days on a high-sodium diet (250 mEq). In microalbuminuric but not in normoalbuminuric IDDM patients, switching from a low to a high-sodium diet was associated with a significant increase in mean BP (from 92 ± 3 to 101 ± 4 mmHg; P < 0.001) and in body weight (2.91 ± 0.63 vs. 1.47 ± 0.26 kg; P < 0.05). Moreover, under high-sodium conditions, angiotensin II infusion (3 ng · kg-1 · min-1) caused a greater increase in mean BP (14 ± 2 vs. 7.4 ± 1 mmHg; P < 0.05) and a smaller reduction in renal plasma flow (-122 ± 29 vs. -274 ± 41 ml · min-1 · 1.73 m2; P < 0.05) in microalbuminuric than in normoalbuminuric IDDM patients. Under low sodium conditions, aldosterone increments after angiotensin II infusion were lower (P < 0.05) in microalbuminuric than in normoalbuminuric IDDM patients. Insulin-mediated glucose disposal was not affected by sodium dietary content, but it was lower in microalbuminuric (P < 0.05) than in normoalbuminuric IDDM patients. The salt-induced changes in mean BP were related to insulin sensitivity (r = -0.78; P < 0.001). In conclusion, in IDDM patients, microalbuminuria is associated with 1) an increased responsiveness of BP to salt intake and angiotensin II, 2) impaired modulation of renal blood flow, and 3) insulin resistance. Therefore, salt sensitivity in IDDM patients clusters with other factors that are likely to play an important role in the pathogenesis of diabetic nephropathy and its cardiovascular complications.
Published: 1998

186. Reducing insulin resistance with metformin: the evidence today

Author: Giannarelli, R., Aragona, M., Coppelli, A., and Del Prato, S.
Published: 2003
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187. The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR) (vol 33, pg 1635, 2012)

Author: Perk, J, De Backer, G, Gohlke, H, Graham, I, Verschuren, WMM, Albus, C, Benlian, P, Boysen, G, Cifkova, R, Ebrahim, S, Fisher, M, Germano, G, Hobbs, R, Karadeniz, S, Mezzani, A, Prescott, E, Ryden, L, Scherer, M, Syvanne, M, Cooney, MT, Bax, J, Baumgartner, H, Ceconi, C, Dean, V, Deaton, C, Fagard, R, Hasdai, D, Hoes, A, Kirchhof, P, Knuuti, J, Kolh, P, McDonagh, T, Moulin, C, Popescu, BA, Reiner, Z, Sechtem, U, Tendera, M, Torbicki, A, Vahanian, A, Windecker, S, Funck-Brentano, C, Sirnes, PA, Aboyans, V, Ezquerra, EA, Baigent, C, Brotons, C, Burell, G, Ceriello, A, De Sutter, J, Deckers, J, Del Prato, S, Diener, HC, Fitzsimons, D, Fras, Z, Hambrecht, R, Jankowski, P, Keil, U, Kirby, M, Larsen, ML, Mancia, G, Manolis, AJ, McMurray, J, Pajak, A, Parkhomenko, A, Rallidis, L, Rigo, F, Rocha, E, Ruilope, LM, van der Velde, E, Vanuzzo, D, Viigimaa, M, Volpe, M, Wiklund, O, and Wolpert, C
Published: 2012

188. Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone:impact on cardiovascular events. A randomized controlled trial

Author: Vaccaro, O, Masulli, M, Bonora, E, Del Prato, S, Giorda, Cb, Maggioni, Ap, Mocarelli, C, Nicolucci, A, Rivellese, Aa, Squatrito, Sebastiano, and Riccardi, G.
Subjects: Cardiovascular events, Pioglitazone, Diabetes
Published: 2012

189. Pathogenetic mechanisms and cardiovascular risk: differences between HbA(1c) and oral glucose tolerance test for the diagnosis of glucose tolerance

Author: Bianchi, C, Miccoli, R, Bonadonna, Rc, Giorgino, F, Frontoni, S, Faloia, E, Marchesini, G, Dolci, Ma, Cavalot, F, Cavallo, Gm, Leonetti, F, Del Prato, S, Genfiev, Investigators, and Trovati, Mariella
Subjects: BETA-CELL FUNCTION, GLYCATED HEMOGLOBIN, INSULIN-RESISTANCE, FASTING GLUCOSE, PLASMA-GLUCOSE, A1C, CRITERIA, PERFORMANCE, INTOLERANCE, SECRETION
Published: 2012

190. Cardiorenal End Points in a Trial of Aliskiren for Type 2 Diabetes

Author: Parving, Hh, Brenner, Bm, Mcmurray, Jj, de Zeeuw, D, Haffner, Sm, Solomon, Sd, Chaturvedi, N, Persson, F, Desai, As, Nicolaides, M, Richard, A, Xiang, Z, Brunel, P, Pfeffer, Ma, Viberti, G, Lachin, Jm, Zinman, B, Pedersen, Tr, Villamil, As, Juncos, L, Prager, R, Verpooten, G, Zanella, Mt, Leiter, L, Pan, C, Wang, H, Botero, R, Cifkova, R, Christiansen, Js, Groop, Ph, Marre, M, Haller, H, Nickenig, G, Siamopoulos, K, Gero, L, Maggioni, A, Remuzzi, G, Katayama, Ss, Kim, Sg, Petrulioniene, Z, Lok, D, Kooy, A, Jorde, R, Medina, F, Polonia, J, Wong, Ks, Dukat, A, Rayner, Bl, Ruilope, L, Weiss, L, Wuethrich, R, Sheu, W, Sritara, P, Comlekci, A, Bilous, R, Toto, R, Jamerson, K, Carillo, E, Orias, M, Kuschnir, E, Rusculleda, M, Garcia, S, Farias, E, Lema, L, Hominal, M, Montaña, O, Sala, J, Diaz, M, Piskorz, D, Vita, N, Litwak, L, Sinay, I, Marin, M, Massari, P, Majul, C, Aizemberg, D, Azize, Gm, Bartolacci, I, Reboredo, A, Vico, M, Milesi, R, Sessa, H, Wassermann, A, Margulis, F, Zangroniz, P, Watschinger, B, Toplak, H, Paulweber, B, Drexel, H, Francesconi, C, Foeger, B, Mayer, G, Braun, Rk, Brath, H, Gaal, Lv, Niepen, Pv, Persu, A, Vercammen, C, Vriese, Ad, Coucke, F, Mathieu, C, Fery, F, Treille, S, Meeus, G, Acker, Kv, Scheen, A, Tits, J, Ruige, J, Krzesinski, Jm, Hollanders, G, Liénart, F, Dendale, P, Quinonez, M, Arnouts, P, Vanuytsel, J, Zanella, M, Mion D., Jr, Forti, A, Almeida, F, Cunha, R, de Paula RB, Brandao, A, Rocha, J, Krieger, E, Feitosa, G, Saraiva, J, Martin, J, Hissa, Mn, Schmid, H, Felicio, J, Sgarbi, J, Oigman, W, Bowering, K, Garceau, C, Berlingieri, Jc, Weisnagel, Sj, Hardin, P, Powell, C, Turcot, R, Muirhead, N, Aronson, R, Barima, Yt, Steele, Aw, Pandey, S, Woo, V, Cha, J, Dattani, D, Godin, C, Gupta, M, Saunders, K, Tellier, G, Ting, R, Tobe, S, Chouinard, G, Schlosser, R, Khandwala, H, Ekoe, Jm, Harris, Sb, Pichette, V, Lachance, P, Ooi, Tc, Tildesley, H, Barrett, B, Cournoyer, S, Lu, J, Zhang, H, Liu, X, Yan, S, Qi, X, Li, Q, Li, H, Lv, X, Yang, J, Sun, N, Xia, W, Wang, N, Tong, N, Mei, C, Gu, S, Zhang, J, Chen, X, Li, L, Su, B, Wang, L, Qiu, M, Wu, X, Liu, Z, Jia, W, Xu, G, Dong, J, Zhu, D, Zhang, M, Yan, J, Liu, B, Chen, J, Fu, J, Yan, L, Zhan, X, Zhong, L, Yang, T, Ma, J, Xu, M, Xu, X, Shi, B, Ji, Q, Zhong, H, He, R, Yuan, Z, Zhou, Z, Lin, H, Yang, W, Ke, Y, Hong, T, Franco, C, Casas, L, Triana, A, Jaramillo, C, Hernandez, E, Barrera, C, Blanco, D, Stipal, R, Widimsky, P, Dohnalova, L, Komroskova, M, Kvapil, M, Belobradkova, J, Tesar, V, Vodnansky, P, Kocourkova, B, Lervang, Hh, Perrild, H, Rossing, P, Oestergaard, O, Juhl, H, Thorsteinsson, B, Snorgaard, O, Urhammer, S, Egstrup, K, Tikkanen, T, Helin, K, Rinne, J, Lahtela, J, Strand, J, Valtonen, E, Saari, M, Kananen, K, Savela, K, Blacher, J, Aldigier, Jc, Zaoui, P, Fauvel, Jp, Gouet, D, Valensi, Pe, Charpentier, G, Marechaud, R, Penfornis, A, Ovize, M, Kovalchuck, Aa, Dellanna, F, Schoen, N, Groeschel, W, Eickhoff, F, Hanefeld, M, Merke, J, Rambausek, M, Zimmermann, U, Stuetz, W, Vosskuehler, A, Hevendehl, G, Schax, U, Lehmann, G, Haack, A, Hilgenberg, J, Klausmann, G, Adelberger, V, Gessner, S, Fiesselmann, A, Oerter, E, Hohenstatt, T, Groeschel, A, Behnke, T, Sisting, Rt, Schoch, D, Bieler, T, Schleyer, S, Altes, U, Klepzig, C, Rudofsky, G, Mueller, G, Burkhardt, F, Reschke, K, Senftleber, I, Wiesweg, Ck, Herrmann, Hj, Brandstetter, R, Segner, A, Schmitt, H, Rippert, R, Goebel, R, Schreibmueller, F, Pencz, I, Ott, P, Migdalis, I, Pappas, S, Pagkalos, E, Yalouris, A, Tsapas, A, Maltezos, E, Tentolouris, N, Papadakis, I, Ioannidis, G, Goumenos, D, Corona, V, Gonzalez, R, Haase, F, Monterroso, V, Sánchez, V, Turcios, E, Wyss, F, Arango, Jl, Bako, B, Deak, L, Dömötör, E, Dudas, M, Fulop, T, Kiss, I, Koranyi, L, Lengyel, Z, Nyirati, G, Oroszlan, T, Aniko, S, Vörös, P, Kapocsi, J, Wittmann, I, Paragh, G, Abraham, G, Tandon, N, Thomas, N, Mohan, V, Sahay, R, Sethi, B, Rao, V, Kumar, S, Chowdhury, S, Dharmalingam, M, Seshiah, V, Bantwal, G, Viswanathan, V, Yajnik, C, Adhikari, P, Krishnan, U, Varthakavi, P, Hiremath, J, Bhattacharyya, A, Dani, S, Modi, Kk, Glorioso, N, Morosetti, M, Veglio, Franco, Perticone, F, Dotta, F, Quarello, F, Sesti, G, Aiello, A, D'Ospina, A, Giordano, C, Novo, S, Santoro, A, Ferri, C, Capuano, V, Trimarco, B, Tonolo, G, Villa, G, De Pellegrin, A, Zanette, G, Federici, M, Aucello, G, Piatti, P, Vinciguerra, A, Mannarino, E, Taddei, S, Filetti, S, Grandaliano, G, Marchionni, N, Lambiase, C, Locatelli, F, Scanferla, F, Lembo, G, Leotta, S, Mos, L, Calatola, P, Fogari, R, David, S, Pedrinelli, R, Pignone, Am, Cozzolino, D, Bevilacqua, Mt, Catena, C, Del Prato, S, Cerasola, G, Frontoni, S, Falcone, C, Porta, A, Bonora, E, Cocchi, R, Fucili, A, Frisinghelli, A, Volpe, M, Carugo, S, Gambardella, S, Spagnuolo, V, Maglia, G, D'Angelo, Ar, Corsi, A, Limone, Pp, Guarnieri, A, Ghigo, Ezio, Ronchi, E, Ravera, M, Scioli, Ga, Sekiguchi, M, Aoki, S, Ogawa, Y, Seino, H, Onishi, Y, Tojo, A, Narimiya, M, Iwaita, Y, Takeda, H, Shimizu, H, Yamada, T, Kojima, S, Zushi, S, Kaneko, S, Matsumoto, A, Kajiyama, S, Fujita, H, Shikata, K, Tone, A, Matsubayashi, S, Tanaka, S, Sekigami, T, Tatsukawa, Y, Abe, N, Kawahara, K, Kasahara, H, Maeda, Y, Suzuki, Y, Okamoto, H, Tachi, K, Yamada, K, Uzu, T, Itou, T, Fukui, T, Kim, S, Kim, Y, Cho, W, Kwak, I, Chae, D, Oh, H, Ha, S, Shin, Y, Cha, D, Kang, S, Lim, C, Song, J, Kwon, Y, Badariene, J, Labutiniene, Ip, Zabuliene, L, Poteliuniene, V, Miglinas, M, van den Meiracker AH, Gregoor, Pj, Luik, Aj, van Loon BJ, Feenstra, Hj, Kaasjager, Ha, Viergever, Pp, Woittiez, Aj, van Bemmel, T, Lieverse, Ag, Simsek, S, Gaillard, Ca, van der Zwaan, C, Lok, Dj, Spiering, W, Nierop, Pr, Baggen, Mg, Leendert, Rj, de Jong, A, Leurs, Pb, Vincent, Hh, Wins, Eh, Voors, Aa, Ronner, E, Heeg, Je, van Hal JM, Boermans, T, Feis, Wl, Mostard, G, Bakker, Rc, Dunselman, Ph, Skeie, S, Istad, H, Skjelvan, G, Gronert, J, Tomala, T, Gudnason, S, Torvik, Dt, Risberg, K, Abedini, S, Cabrera, W, Medina, B, Herrada, B, Saavedra, A, Polonia, Dj, Providencia, Dl, Carvalho, D, Vasconcelos, Mp, da Silva GF, Branco, P, Gil, Dv, da Costa AG, da Silva PM, Arez, L, Martins, L, Birne, R, Dzuponova, J, Surovcikova, M, Culak, J, Filipova, S, Andre, I, Stevlik, J, Uhliar, R, Fabryova, L, Benacka, J, Koleny, D, Szentivanyi, M, Spisak, V, Pella, D, Pastrnakova, E, Martinka, E, Chua, T, Lau, T, Ng, Tg, Yeoh, Ly, Bhana, Sa, Rayner, B, Wellmann, H, Amod, A, Ranjith, N, Ahmed, F, Rheeder, P, Makan, H, Naicker, P, Podgorski, G, De Teresa, E, Olivan, J, Fernandez, Vl, Povedano, St, Terns, M, Ricart, W, Gonzalez, Jm, Fernandez, P, Parreño Lde, T, Redon, J, Parra, J, Calvo, C, Lopez, I, Puig, Jg, Calle, A, Garcia, Jc, Lopez, Jm, Jimenez, Ml, Fraile, B, Perez, Js, Nadal, Jj, Guija, E, Calviño, J, Barrios, V, Iglesias, Jn, Armario, P, Garcia, M, Aranda, P, Brotons, C, Gomez, P, Catelao, Am, Cusachs, Ar, Sarro, M, Martinez, V, dell Valle MH, Trias, F, Comas, A, Salvador, N, Martinez, F, Hernandez, F, Martinez, J, Mateos, C, Peral, Jl, Tolosana, J, Sobrino, J, Isart, J, Vizcaino, J, Vega, Ff, Zamorano, Jl, Bacariza, M, Soubriet, A, Fernández Cruz, A, Querejeta, R, Leira, Vm, Iglesias, Fe, Ibrik, O, Martin, D, Nanclares, Ms, Mediavilla, Jd, Galceran, Jm, Lopez, A, Muros, T, Pascual, J, Casalla, F, Tornero, F, Fernandez, G, Pettersson, P, Olsen, H, Franke, F, Stroembom, U, Furuland, H, Larnefelt, H, Allemann, Y, Krapf, R, Gerber, P, Munger, R, Hayoz, D, Graf, Hj, Burnier, M, Petrillo, A, Batt, R, Constam, En, Moccetti, T, Bianda, T, Rickli, H, Bulliard, C, Wu, Kd, Lin, Sh, Wu, Cj, Sheu, Wh, Su, Sl, Chen, Sc, Chou, Cw, Lee, Ct, Yang, Tc, Chen, Hc, Sukonthasarn, A, Sriratanasathavorn, C, Eiam Ong, S, Supasyndh, O, Chanchairujira, T, Kitiyakara, C, Arici, M, Usalan, C, Guneri, S, Koc, M, Kalender, B, Ates, K, Gurgun, C, Araz, M, Demirbas, B, Biernacki, W, Calvert, J, Eavis, P, Kerrane, J, Litchfield, J, Middleton, A, Roberts, J, Simpson, H, Charles, H, Jardine, A, Fisher, M, Banerjee, D, Gallen, I, Gnudi, L, Harvey, J, O'Hare, P, Vora, J, Winocour, P, Soran, H, Browne, D, Darko, D, Mancebo, Jg, de Roa ER, Antepara, N, Carrillo, E, Berrizbeitia, M, Guevara, L, Pernalete, N, Ontiveros, C, Zigrang, W, Blakney, E, Rosenblit, P, Weinstein, R, Klaff, L, Lipetz, R, Busick, E, Tung, P, Cooperman, M, Michael, S, Sun, Ch, Hart, T, Maddux, A, Bowden, R, East, C, Arakaki, R, Villafuerte, B, Mamish, Z, Mendez, R, Connery, L, Nour, K, Wynne, A, Busch, R, Zamora, B, Sachson, R, Prasad, J, Lasala, G, Smith, M, Fitz Patrick, D, Ruiz Rivera, L, Barranco, E, Solomon, R, Woolley, A, Brown, C, Freedman, Z, Schmidt, S, Pollock, J, Ruddy, M, Kopyt, Np, Bazzi, A, Horowitz, B, Feng, W, Wahl, T, Duprez, D, Gilbert, J, Steigerwalt, S, Jacqmein, J, Gorton, S, 3rd, Allison J., Pino, J, Lock, J, Leimbach, W, Anderson, J, Beacom, M, Craig, W, Gorson, D, Kerstein, H, Segal, S, Downey, H, Ledger, G, Mcgill, J, Gabriel, J, Nolen, T, Levinson, L, Williams, T, Levenson, D, Lerman, S, Minehart, C, Agarwal, N, Verma, S, Valitutto, M, Demetry, K, Mersey, J, Koeper, D, Fanti, P, Eng, G, Grimm, R, Fagan, T, Bajaj, M, Katz, L, Portnay, G, Altschuller, A, Desai, V, Bilazarian, S, Ipp, E, Rodelas, R, Burstein, D, Berg, J, Velez, J, Lund, R, Rekhi, A, Martin, E, Robertson, D, Singh, N, Narayan, P, Moustafa, M, Lanier, D, Seidner, M, Phillips, A, Vaughters, B, Sprague, A, Swartz, S, Lopez, R, Kumar, J, Bressler, P, Sadler, L, Wise, J, Kilbane, A., and Groningen Kidney Center (GKC)
Subjects: Male, Hyperkalemia, CARDIOVASCULAR MORTALITY, BLOOD-PRESSURE, Angiotensin-Converting Enzyme Inhibitors, Type 2 diabetes, GLOMERULAR-FILTRATION-RATE, DOUBLE-BLIND, chemistry.chemical_compound, Fumarates, cardiovascular disease, Renin, Treatment Failure, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, 610 Medicine & health, diabetes, Medicine (all), Hazard ratio, aliskiren, diabete, trial clinico, Liter, General Medicine, Middle Aged, hypertension, Cardiovascular Diseases, Combination, HEART-FAILURE, Drug Therapy, Combination, Female, Kidney Diseases, type 2 diabetes, medicine.symptom, Type 2, medicine.medical_specialty, Patient Dropouts, Urology, Hypokalemia, Aliskiren, chronic kidney disease, Placebo, Angiotensin Receptor Antagonists, LEFT-VENTRICULAR DYSFUNCTION, Drug Therapy, Double-Blind Method, Diabetes Mellitus, medicine, Humans, CONVERTING-ENZYME INHIBITORS, Antihypertensive Agents, Aged, Amides, Diabetes Mellitus, Type 2, Follow-Up Studies, business.industry, medicine.disease, Confidence interval, Surgery, Blood pressure, MYOCARDIAL-INFARCTION, chemistry, SYSTOLIC DYSFUNCTION, FOLLOW-UP, business
Abstract: BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular and renal events in patients with type 2 diabetes and chronic kidney disease, cardiovascular disease, or both. METHODS In a double-blind fashion, we randomly assigned 8561 patients to aliskiren (300 mg daily) or placebo as an adjunct to an angiotensin-converting-enzyme inhibitor or an angiotensin-receptor blocker. The primary end point was a composite of the time to cardiovascular death or a first occurrence of cardiac arrest with resuscitation; nonfatal myocardial infarction; nonfatal stroke; unplanned hospitalization for heart failure; end-stage renal disease, death attributable to kidney failure, or the need for renal-replacement therapy with no dialysis or transplantation available or initiated; or doubling of the baseline serum creatinine level. RESULTS The trial was stopped prematurely after the second interim efficacy analysis. After a median follow-up of 32.9 months, the primary end point had occurred in 783 patients (18.3%) assigned to aliskiren as compared with 732 (17.1%) assigned to placebo (hazard ratio, 1.08; 95% confidence interval [CI], 0.98 to 1.20; P = 0.12). Effects on secondary renal end points were similar. Systolic and diastolic blood pressures were lower with aliskiren (between-group differences, 1.3 and 0.6 mm Hg, respectively) and the mean reduction in the urinary albumin-to-creatinine ratio was greater (between-group difference, 14 percentage points; 95% CI, 11 to 17). The proportion of patients with hyperkalemia (serum potassium level, = 6 mmol per liter) was significantly higher in the aliskiren group than in the placebo group (11.2% vs. 7.2%), as was the proportion with reported hypotension (12.1% vs. 8.3%) (P CONCLUSIONS The addition of aliskiren to standard therapy with renin-angiotensin system blockade in patients with type 2 diabetes who are at high risk for cardiovascular and renal events is not supported by these data and may even be harmful. (Funded by Novartis; ALTITUDE ClinicalTrials.gov number, NCT00549757.)
Published: 2012
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191. The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation

Author: Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, WMM, Albus, C., Benlian, P., Boysen, G., Cifkova, R., Deaton, C., Ebrahim, S., Fisher, M., Germano, G., Hobbs, R., Hoes, A., Karadeniz, S., Mezzani, A., Prescott, E., Ryden, L., Scherer, M., Syvanne, M., Cooney, M. T., Bax, J., Baumgartner, H., Ceconi, C., Dean, V., Fagard, R., Funck-Brentano, C., Hasdai, D., Kirchhof, P., Knuuti, J., Kolh, P., McDonagh, T., Moulin, C., Popescu, B. A., Sechtem, U., Sirnes, P. A., Tendera, M., Torbicki, A., Vahanian, A., Windecker, S., Aboyans, V., Ezquerra, E. A., Baigent, C., Brotons, C., Burell, G., Ceriello, A., De Sutter, J., Deckers, J., Del Prato, S., Diener, Hans Christoph, Fitzsimons, D., Fras, Z., Hambrecht, R., Jankowski, P., Keil, U., Kirby, M., Larsen, M. L., Mancia, G., Manolis, A. J., McMurray, J., Pajak, A., Parkhomenko, A., Rallidis, L., Rigo, F., Rocha, E., Ruilope, L. M., van der Velde, E., Vanuzzo, D., Viigimaa, M., Volpe, M., Wiklund, O., and Wolpert, C.
Subjects: Medizin
Published: 2012

192. European guidelines on cardiovascular disease prevention in clinical practice (version 2012) : the fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)

Author: Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Z., Verschuren, M., Albus, C., Benlian, P., Boysen, G., Cifkova, R., Deaton, C., Ebrahim, S., Fisher, M., Germano, G., Hobbs, R., Hoes, A., Karadeniz, S., Mezzani, A., Prescott, E., Ryden, L., Scherer, M., Syvanne, M., Scholte Op Reimer, W. J. M., Vrints, C., Wood, D., Zamorano, J. L., Zannad, F., Cooney, M. T., Bax, J., Baumgartner, H., Ceconi, C., Dean, V., Fagard, R., Funck Brentano, C., Hasdai, D., Kirchhof, P., Knuuti, J., Kolh, P., Mcdonagh, T., Moulin, C., Popescu, B. A., Sechtem, U., Sirnes, P. A., Tendera, M., Torbicki, A., Vahanian, A., Windecker, S., Aboyans, V., Ezquerra, E. A., Baigent, C., Brotons, C., Burell, G., Ceriello, A., De Sutter, J., Deckers, J., Del Prato, S., Diener, H. C., Fitzsimons, D., Fras, Z., Hambrecht, R., Jankowski, P., Keil, U., Kirby, M., Larsen, M. L., Mancia, G., Manolis, A. J., Mcmurray, J., Pajak, A., Parkhomenko, A., Rallidis, L., Rigo, F., Rocha, E., Ruilope, L. M., Van Der Velde, E., Vanuzzo, D., Viigimaa, M., Volpe, Massimo, Wiklund, O., Wolpert, C., Authors/task Force Members, Parts Of The Guidelines:, Other Experts Who Contributed T. O., Esc, Committee For Practice Guidelines :., Document, Reviewers, School of Health and Caring Sciences, Linnaeus University, Department of Public Health, University of Gent, University Hospital Center Zagreb, 2nd Department of Internal Medicine, Faculty of Epidemiology and Population Health [London], London School of Hygiene and Tropical Medicine (LSHTM), Primary Care Clinical Sciences, University of Birmingham [Birmingham], Service de Cardiologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Neuroépidémiologie Tropicale (NET), Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), and Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Male, Epidemiology, medicine.medical_treatment, General Practice, physical activity, Blood Pressure, Smoking Prevention, Comorbidity, prevention, Electronic Health Records, Myocardial infarction, ComputingMilieux_MISCELLANEOUS, education.field_of_study, Rehabilitation, Cardiac Rehabilitation, Evidence-Based Medicine, Prognosis, Cardiovascular disease, Lipids, Drug Combinations, nutrition, Cardiovascular Diseases, Cardiology and Cardiovascular Medicine, Diagnostic Imaging, medicine.medical_specialty, Hypercholesterolemia, Advisory Committees, Health Promotion, Risk Assessment, Medication Adherence, European guidelines, cardiovascular disease prevention, Humans, education, Physician's Role, Exercise, Life Style, Aged, Primary Health Care, Patient Selection, Cardiovascular Agents, medicine.disease, Self Care, Health promotion, Early Diagnosis, Diabetes Mellitus, Type 2, Cardiology, Disease prevention, Risk Reduction Behavior, Biomarkers, Diabetic Angiopathies, Systolic hypertension, Risk Factors, Preventive Health Services, Applied Psychology, Middle Aged, Clopidogrel, Clinical Practice, Hospitalization, Europe, Treatment Outcome, Heart Function Tests, Hypertension, Female, Heart Protection Study, medicine.drug, Adult, Consensus, United Kingdom Prospective Diabetes Study, Population, MEDLINE, psychosocial factors, risk assessment, risk management, smoking, Nurse's Role, Predictive Value of Tests, Internal medicine, medicine, Obesity, cardiovascular diseases, Antihypertensive Agents, Task force, business.industry, Percutaneous coronary intervention, Diet, Socioeconomic Factors, Family medicine, Heart failure, Chronic Disease, Smoking Cessation, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Delivery of Health Care, Stress, Psychological, Kidney disease
Abstract: ABI : ankle–brachial index ACCORD : Action to Control Cardiovascular Risk in Diabetes ADVANCE : Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation AGREE : Appraisal of Guidelines Research and Evaluation AHA : American Heart Association apoA1 : apolipoprotein A1 apoB : apolipoprotein B CABG : coronary artery bypass graft surgery CARDS : Collaborative AtoRvastatin Diabetes Study CCNAP : Council on Cardiovascular Nursing and Allied Professions CHARISMA : Clopidogrel for High Athero-thrombotic Risk and Ischemic Stabilisation, Management, and Avoidance CHD : coronary heart disease CKD : chronic kidney disease COMMIT : Clopidogrel and Metoprolol in Myocardial Infarction Trial CRP : C-reactive protein CURE : Clopidogrel in Unstable Angina to Prevent Recurrent Events CVD : cardiovascular disease DALYs : disability-adjusted life years DBP : diastolic blood pressure DCCT : Diabetes Control and Complications Trial ED : erectile dysfunction eGFR : estimated glomerular filtration rate EHN : European Heart Network EPIC : European Prospective Investigation into Cancer and Nutrition EUROASPIRE : European Action on Secondary and Primary Prevention through Intervention to Reduce Events GFR : glomerular filtration rate GOSPEL : Global Secondary Prevention Strategies to Limit Event Recurrence After MI GRADE : Grading of Recommendations Assessment, Development and Evaluation HbA1c : glycated haemoglobin HDL : high-density lipoprotein HF-ACTION : Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing HOT : Hypertension Optimal Treatment Study HPS : Heart Protection Study HR : hazard ratio hsCRP : high-sensitivity C-reactive protein HYVET : Hypertension in the Very Elderly Trial ICD : International Classification of Diseases IMT : intima-media thickness INVEST : International Verapamil SR/Trandolapril JTF : Joint Task Force LDL : low-density lipoprotein Lp(a) : lipoprotein(a) LpPLA2 : lipoprotein-associated phospholipase 2 LVH : left ventricular hypertrophy MATCH : Management of Atherothrombosis with Clopidogrel in High-risk Patients with Recent Transient Ischaemic Attack or Ischaemic Stroke MDRD : Modification of Diet in Renal Disease MET : metabolic equivalent MONICA : Multinational MONItoring of trends and determinants in CArdiovascular disease NICE : National Institute of Health and Clinical Excellence NRT : nicotine replacement therapy NSTEMI : non-ST elevation myocardial infarction ONTARGET : Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial OSA : obstructive sleep apnoea PAD : peripheral artery disease PCI : percutaneous coronary intervention PROactive : Prospective Pioglitazone Clinical Trial in Macrovascular Events PWV : pulse wave velocity QOF : Quality and Outcomes Framework RCT : randomized clinical trial RR : relative risk SBP : systolic blood pressure SCORE : Systematic Coronary Risk Evaluation Project SEARCH : Study of the Effectiveness of Additional Reductions in Cholesterol and SHEP : Systolic Hypertension in the Elderly Program STEMI : ST-elevation myocardial infarction SU.FOL.OM3 : SUpplementation with FOlate, vitamin B6 and B12 and/or OMega-3 fatty acids Syst-Eur : Systolic Hypertension in Europe TNT : Treating to New Targets UKPDS : United Kingdom Prospective Diabetes Study VADT : Veterans Affairs Diabetes Trial VALUE : Valsartan Antihypertensive Long-term Use VITATOPS : VITAmins TO Prevent Stroke VLDL : very low-density lipoprotein WHO : World Health Organization ### 1.1 Introduction Atherosclerotic cardiovascular disease (CVD) is a chronic disorder developing insidiously throughout life and usually progressing to an advanced stage by the time symptoms occur. It remains the major cause of premature death in Europe, even though CVD mortality has …
Published: 2012

193. Insulin degludec, an ultra-longacting basal insulin, versus insulin glargine in basal-bolus treatment with mealtime insulin aspart in type 2 diabetes (BEGIN Basal-Bolus Type 2): a phase 3, randomised, open-label, treat-to-target non-inferiority trial

Author: Garber, Aj, King, Ab, Del Prato, S, Sreenan, S, Balci, Mk, Muñoz Torres, M, Rosenstock, J, Endahl, La, Francisco, Am, Hollander, P, Protich, M, Ivanov, V, Veleva, N, Pichmanova, M, Guerenova, J, Hristozov, K, Slavcheva, A, Petrova, Gancheva, Prakova Teneva, Z, Böhmer, M, Clever, Hu, Kaiser, M, Peter Kempe, H, Mölle, A, Paulus, R, Rose, L, Sauter, J, Kinsley, B, Nolan, J, Hayes, F, Joshi, P, Khutsoane, Dt, Reddy, J, Mayet, L, Burgess, Lj, Raya, Pm, Cros, Mr, Calle, A, Candil, Sd, Soto, A, Francisco, J, Torres, M, Dominguez, Jr, Mesa, J, Mur, Al, Filetti, S, Piatti, P, Vespasiani, G, Santeusanio, F, Fanelli, Carmine Giuseppe, Mannucci, E, Consoli, A, Pata, P, Cignarelli, M, Borzì, V, Trevisan, R, Serban, V, Catrinoiu, D, Creteanu, G, Pop, L, Coman, A, Dogadin, S, Dvoryashina, I, Karpova, I, Lysenko, T, Smirnova, E, Yakusevich, V, Fábry, J, Ilavská, A, Tomášová, L, Tošerová, E, Chow, Fc, Karsidag, K, Erguney, M, Akbay, E, Balçi, Mk, Anderson, C, Baker, C, Berbano, R, Blevins, T, Broadstone, V, Brody, M, Brunner, J, Brusco, O, Case, C, Cherlin, R, Chuck, L, Clower, J, Connor, G, Cooperman, M, Paysinger, A, Early, M, Elliott, S, Fitz Patrick, D, Furlong, K, Garber, A, Glaser, L, Albert, S, Griffing, G, Handke, L, Harris, R, Hermayer, K, Huntley, R, Kaye, W, Kennedy, J, King, A, Klein, E, Lipetz, R, Snell, P, Morawski, E, Nurnberg, R, Orr, R, Osei, K, Palace, E, Raad, G, Rasmussen, B, Reeves, M, Roberts, V, Rodbard, H, Rosenblit, P, Selam, Jl, Shaw, S, Shelmet, J, Simon, H, Smith, M, Stringam, S, Sussman, A, Testa, J, Mazza, A, Varano, S, Warren, M, Winkle, P, Wise, J, Aroda, V, Strzinek, R, Wong, M, Pollock, J, and Bode, B.
Published: 2012

194. Manuale Medico di Diagnostica e Terapia Roversi XI Edizione. (Editori: Renato Lauro, Francesco Rossi e Alberto Zanchetti; Revisore: Gianfranco Pagano)

Author: Savarino, V., Craxi, A., Prisco D, D., Di Pasquale, G., Trimarco, B., Fabbri, Leonardo, Dal Canton, A., Colao, A. M., Del Prato, S., Perpignano, G., Scorza, R., Concia, E., and Leoni, P.
Subjects: manuale medicina
Published: 2012

195. Telecare Provides comparable efficacy to conventional self-monitored blood glucose in patients with type 2 diabetes titrating one injection of insulin glulisine-the ELEONOR study

Author: Del Prato, S., Nicolucci, A., Lovagnini Scher, A. C., Turco, S., Leotta, S., Vespasiani, G., Lauro, R., Dotta, Francesco, Giorgino, F., Giorda, C., and ELEONOR Study Group
Subjects: Insulin glulisine, Adult, Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Gastroenterology, law.invention, Injections, Endocrinology, Randomized controlled trial, law, Internal medicine, Diabetes mellitus, Medicine, Humans, Hypoglycemic Agents, Insulin, Aged, Monitoring, Physiologic, Glycated Hemoglobin, Meal, business.industry, Blood Glucose Self-Monitoring, nutritional and metabolic diseases, Fasting, Middle Aged, medicine.disease, Postprandial Period, Metformin, Telemedicine, Medical Laboratory Technology, Postprandial, Treatment Outcome, Diabetes Mellitus, Type 2, Female, Hemoglobin, business, medicine.drug
Abstract: We compared telecare and conventional self-monitored blood glucose (SMBG) programs for titrating the addition of one bolus injection of insulin glulisine in patients with type 2 diabetes uncontrolled on oral hypoglycemic agents for ≥3 months who were first titrated with basal insulin glargine.This randomized, multicenter, parallel-group study included 241 patients (mean screening glycosylated hemoglobin [HbA(1c)], 8.8% [73 mmol/mol]). In the run-in phase, any antidiabetes medication, except for metformin, was discontinued. Metformin was then up-titrated to 2 g/day (1 g twice daily) until study completion. Following run-in, all patients started glargine for 8-16 weeks, targeting fasting plasma glucose (FPG) ≤5.6 mmol/L using conventional SMBG. Patients with FPG ≤7 mmol/L added a glulisine dose at the meal with the highest postprandial plasma glucose excursion, titrated to target 2-h postprandial plasma glucose level7.8 mmol/L using telecare or SMBG for 24 weeks. Patients with FPG7 mmol/L at week 16 were withdrawn from the study.After glargine titration, 224 patients achieved FPG ≤7 mmol/L, without any difference between telecare and SBMG groups (mean±SD, 6.2±0.8 vs. 6.0±0. 9 mmol/L, respectively). HbA(1c) levels were lower following titration and were similar for telecare and SMBG (7.9±0.9% vs. 7.8±0.9% [63 vs. 62 mmol/mol], respectively). Adding glulisine further reduced HbA(1c) in both groups (-0.7% vs. -0.7%); 45.2% and 54.8% (P=0.14), respectively, of patients achieved HbA(1c) ≤7.0% (≤53 mmol/mol). Weight change and hypoglycemia were similar between groups.Patients adding one dose of glulisine at the meal with the highest postprandial plasma glucose excursion to titrated basal glargine achieved comparable improvements in glycemic control irrespective of traditional or telecare blood glucose monitoring.
Published: 2011

196. Optimizing insulin glargine plus one injection of insulin glulisine in type 2 diabetes in the ELEONOR study: similar effects of telecare and conventional self-monitoring of blood glucose on patient functional health status and treatment satisfaction

Author: Nicolucci, A., Del Prato, S., Vespasiani, G., Lauro, R., Dotta, Francesco, Bosi, E., Giorgino, F., Giorda, C. B., and ELEONOR Study Group
Published: 2011

197. La terapia insulinica nel diabete mellito tipo 2

Author: Del Prato, S., Sesti, G, Bonadonna, R. C., Consoli, A, Dotta, F, Fanelli, Carmine Giuseppe, Mannucci, E., Miccoli, R, Pontiroli, Ae, Pozzilli, P, Vespasiani, G, and Vigneri, R.
Published: 2011

198. Metabolic syndrome in subjects at high risk for type 2 diabetes: The genetic, physiopathology and evolution of type 2 diabetes (GENFIEV) study. Nutr Metab Cardiovasc Dis. 2010 Nov 5

Author: Bianchi, C, Miccoli, R, Bonadonna, Rc, Giorgino, F, Frontoni, S, Faloia, E, Marchesini, G, Dolci, Ma, Alviggi, L, Gnasso, A, Consoli, A, Cavalot, F, Cavallo, Maria Gisella, Leonetti, Frida, Giaccari, A, DEL PRATO, S, and ON BEHALF OF THE GENFIEV INVESTIGATORS
Published: 2011

199. Diabete e cancro

Author: Del Prato, S, Fanelli, Carmine Giuseppe, Giaccari, A, Mannucci, E, Sciacca, L, Torri, V, and nome della Società Italiana di Diabetologia, A.
Published: 2011

200. Benefits of pancreas transplantation on coronary atherosclerosis and microvascular dysfunction: a serial IVUS study

Author: Marco De Carlo, Donati, F., Misuraca, L., Marchetti, P., Papini, B., Barsotti, M., Vistoli, F., Del Prato, S., Boggi, U., and Petronio, A. S.
Published: 2011

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