Search

Your search keyword '"Deng, Chu-Xia"' showing total 987 results
Start Over Author "Deng, Chu-Xia"
987 results on '"Deng, Chu-Xia"'

153. BRCA1 Deficiency: BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis (Adv. Sci. 6/2020)

Author

Chen, Qiang, primary, Lei, Josh Haipeng, additional, Bao, Jiaolin, additional, Wang, Haitao, additional, Hao, Wenhui, additional, Li, Licen, additional, Peng, Cheng, additional, Masuda, Takaaki, additional, Miao, Kai, additional, Xu, Jun, additional, Xu, Xiaoling, additional, and Deng, Chu‐Xia, additional

Published
2020
Full Text
View/download PDF

161. Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M4 muscarinic acetylcholine receptor knockout mice

Author

Gomeza, Jesus, Zhang, Lu, Kostenis, Evi, Felder, Christian, Bymaster, Frank, Brodkin, Jesse, Shannon, Harlan, Xia, Bing, Deng, Chu-Xia, and Wess, Jurgen

Subjects
Acetylcholine -- Receptors, Dopamine receptors -- Physiological aspects, Mice -- Physiological aspects, Muscarinic receptors -- Physiological aspects, Neural transmission -- Research, Science and technology
Abstract

Muscarinic acetylcholine receptors ([M.sub.1]-[M.sub.5]) regulate many key functions of the central and peripheral nervous system. Primarily because of the lack of receptor subtype-selective ligands, the precise physiological roles of the individual muscarinic receptor subtypes remain to be elucidated. Interestingly, the [M.sub.4] receptor subtype is expressed abundantly in the striatum and various other forebrain regions. To study its potential role in the regulation of locomotor activity and other central functions, we used gene-targeting technology to create mice that lack functional [M.sub.4] receptors. Pharmacologic analysis of [M.sub.4] receptor-deficient mice indicated that [M.sub.4] receptors are not required for muscarinic receptor-mediated analgesia, tremor, hypothermia, and salivation. Strikingly, [M.sub.4] receptor-deficient mice showed an increase in basal locomotor activity and greatly enhanced locomotor responses (as compared with their wild-type littermates) after activation of D1 dopamine receptors. These results indicate that [M.sub.4] receptors exert inhibitory control on D1 receptor-mediated locomotor stimulation, probably at the level of striatal projection neurons where the two receptors are coexpressed at high levels. Our findings offer new perspectives for the treatment of Parkinson's disease and other movement disorders that are characterized by an imbalance between muscarinic cholinergic and dopaminergic neurotransmission.

Published
1999

167. Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2

Author

Weinstein, Michael, Yang, Xiao, Li, Cuiling, Xu, Xiaoling, Gotay, Jessica, and Deng, Chu-Xia

Subjects
Transforming growth factors -- Research, Gastrulation -- Research, Science and technology
Abstract

smad genes constitute a family of nine members whose products serve as intracellular mediators of transforming growth factor [Beta] signals. SMAD2, which is a tumor suppressor involved in colorectal and lung cancer, has been shown to induce dorsal mesoderm in Xenopus laevis in response to transforming growth factor [Beta] and activins. The smad2 gene is expressed ubiquitously during murine embryogenesis and in many adult mouse tissues. Animals that lacked smad2 died before 8.5 days of development (E8.5). E6.5 homozygous mutants were smaller than controls, lacked the extraembryonic portion of the egg cylinder, and appeared strikingly similar to E6.5 smad4 mutants. This similarity was no longer evident at E7.5, however, because the smad2 mutants contained embryonic ectoderm within their interiors. Molecular analysis showed that smad2 mutant embryos did not undergo gastrulation or make mesoderm. The results demonstrate that smad2 is required for egg cylinder elongation, gastrulation, and mesoderm induction.

Published
1998

169. Social interaction and sensorimotor gating abnormalities in mice lacking Dv/1

Author

Lijam, Nardos, Paylor, Richard, McDonald, Michael P., Crawley, Jacqueline N., Deng, Chu-Xia, Herrup, Karl, Stevens, E Karen, Maccaferri, Gianmaria, McBain, Chris J., Sussman, Daniel J., and Wynshaw-Boris, Anthony

Subjects
Mice, mutant strains -- Observations, Mental health -- Research, Biological sciences
Abstract

Gene targeting was used to create mice completely deficient for Dv/1, a mouse homolog of the Drosphila segment polarity gene Dishevelled. The mice were viable, fertile and structurally normal, but showed reduced social interaction. Such mutants could therefore act as models for certain human psychiatric disorders.

Published
1997

181. Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism

Author

Collin de l’Hortet, Alexandra, primary, Takeishi, Kazuki, additional, Guzman-Lepe, Jorge, additional, Morita, Kazutoyo, additional, Achreja, Abhinav, additional, Popovic, Branimir, additional, Wang, Yang, additional, Handa, Kan, additional, Mittal, Anjali, additional, Meurs, Noah, additional, Zhu, Ziwen, additional, Weinberg, Frank, additional, Salomon, Michael, additional, Fox, Ira J., additional, Deng, Chu-Xia, additional, Nagrath, Deepak, additional, and Soto-Gutierrez, Alejandro, additional

Published
2019
Full Text
View/download PDF

184. Abstract 3156: Pathway Specific Functional Biomarkers for the Early Detection of Liver Cancer

Author

Shetty, Kirti, primary, Deng, Chu-Xia, additional, Jogunoori, Wilma S., additional, Amdur, Richard, additional, Resar, Linda S., additional, Latham, Patricia, additional, Mazumder, Raja, additional, Horvath, Anelia, additional, Nguyen, Bao-Ngoc, additional, Li, Shulin, additional, Wu, Xifeng, additional, Yu, Herbert, additional, Wong, Linda L., additional, White, Jon, additional, Silver, Sylvia, additional, Rashid, Asif, additional, Kundra, Vikas, additional, Wang, Xin Wei, additional, and Mishra, Lopa, additional

Published
2019
Full Text
View/download PDF

187. SIRT3 promotes antimycobacterial defenses by coordinating mitochondrial and autophagic functions

Author

Kim, Tae Sung, primary, Jin, Yeung Bae, additional, Kim, Yi Sak, additional, Kim, Sup, additional, Kim, Jin Kyung, additional, Lee, Hye-Mi, additional, Suh, Hyun-Woo, additional, Choe, Jin Ho, additional, Kim, Young Jae, additional, Koo, Bon-Sang, additional, Kim, Han-Na, additional, Jung, Mingyu, additional, Lee, Sang-Hee, additional, Kim, Don-Kyu, additional, Chung, Chaeuk, additional, Son, Ji-Woong, additional, Min, Jung-Joon, additional, Kim, Jin-Man, additional, Deng, Chu-Xia, additional, Kim, Hyun Seok, additional, Lee, Sang-Rae, additional, and Jo, Eun-Kyeong, additional

Published
2019
Full Text
View/download PDF

188. Targeting immune checkpoint B7-H3 antibody–chlorin e6 bioconjugates for spectroscopic photoacoustic imaging and photodynamic therapy

Author

Zhu, Lipeng, primary, Liu, Jie, additional, Zhou, Guangyu, additional, Ng, Hoi Man, additional, Ang, Irene L., additional, Ma, Guofang, additional, Liu, Yubin, additional, Yang, Shuo, additional, Zhang, Fengjuan, additional, Miao, Kai, additional, Poon, Terence C. W., additional, Zhang, Xuanjun, additional, Yuan, Zhen, additional, Deng, Chu-Xia, additional, and Zhao, Qi, additional

Published
2019
Full Text
View/download PDF

192. Oxygen‐Enriched Metal‐Phenolic X‐Ray Nanoprocessor for Cancer Radio‐Radiodynamic Therapy in Combination with Checkpoint Blockade Immunotherapy.

Author

Sang, Wei, Xie, Lisi, Wang, Guohao, Li, Jie, Zhang, Zhan, Li, Bei, Guo, Sen, Deng, Chu‐Xia, and Dai, Yunlu

Subjects
OXYGEN carriers, CANCER treatment, X-rays, REACTIVE oxygen species, IMMUNOTHERAPY, DNA damage
Abstract

Radiotherapy (RT) based on DNA damage and reactive oxygen species (ROS) generation has been clinically validated in various types of cancer. However, high dose‐dependent induced toxicity to tissues, non‐selectivity, and radioresistance greatly limit the application of RT. Herein, an oxygen‐enriched X‐ray nanoprocessor Hb@Hf‐Ce6 nanoparticle is developed for improving the therapeutic effect of RT‐radiodynamic therapy (RDT), enhancing modulation of hypoxia tumor microenvironment (TME) and promoting antitumor immune response in combination with programmed cell death protein 1 (PD‐1) immune checkpoint blockade. All functional molecules are integrated into the nanoparticle based on metal‐phenolic coordination, wherein one high‐Z radiosensitizer (hafnium, Hf) coordinated with chlorin e6 (Ce6) modified polyphenols and a promising oxygen carrier (hemoglobin, Hb) is encapsulated for modulation of oxygen balance in the hypoxia TME. Specifically, under single X‐ray irradiation, radioluminescence excited by Hf can activate photosensitizer Ce6 for ROS generation by RDT. Therefore, this combinatory strategy induces comprehensive antitumor immune response for cancer eradication and metastasis inhibition. This work presents a multifunctional metal‐phenolic nanoplatform for efficient X‐ray mediated RT‐RDT in combination with immunotherapy and may provide a new therapeutic option for cancer treatment. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

193. Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes.

Author

Peng, Cheng, Hou, Sheng‐Tao, Deng, Chu‐Xia, and Zhang, Yandong

Subjects
GLYCOLYSIS, PYRUVATE dehydrogenase kinase, GENETIC regulation, DNA demethylation, RNA helicase, CANCER cell proliferation
Abstract

Cancer cells metabolize glucose through glycolysis to promote cell proliferation even with abundant oxygen. Multiple glycolysis genes are deregulated during cancer development. Despite intensive effort, the cause of their deregulation remains incompletely understood. Here in this study, we discovered that DHX33 plays a critical role in Warburg effect of cancer cells. DHX33 deficient cells have markedly reduced glycolysis activity. Through RNA‐seq analysis, we found multiple critical genes involved in Warburg effect were downregulated after DHX33 deficiency. These genes include lactate dehydrogenase A (LDHA), pyruvate dehydrogenase kinase 1 (PDK1), pyruvate kinase muscle isoform 2 (PKM2), enolase 1 (ENO1), ENO2, hexokinase 1/2, among others. With LDHA, PDK1, and PKM2 as examples, we further revealed that DHX33 altered the epigenetic marks around the promoter of glycolytic genes. This is through DHX33 in complex with Gadd45a—a growth arrest and DNA damage protein. DHX33 is required for the loading of Gadd45a and DNA dioxygenase Tet1 at the promoter sites, which resulted in active DNA demethylation and enhanced histone H4 acetylation. We conclude that DHX33 changes local epigenetic marks in favor of the transcription of glycolysis genes to promote cancer cell proliferation. Our study highlights the significance of RNA helicase DHX33 in Warburg effect and cancer therapeutics. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

194. Cancer cells escape p53’s tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation

Author

Tang, Jun, Peng, Weiyan, Feng, Yixiao, Le, Xin, Wang, Kang, Xiang, Qin, Li, Lili, Wang, Yan, Xu, Can, Mu, Junhao, Xu, Ke, Ji, Ping, Tao, Qian, Huang, Ailong, Deng, Chu-Xia, Lin, Yong, and Xiang, Tingxiu

Abstract

The inactivation of tumor-suppressor genes contributes heavily to oncogenesis. The mutation of TP53 has been well-studied and recognized as a major factor in the development of tumors. Yet other means of p53 inactivation has not been well-elucidated. We previously identified a hypermethylated gene ZDHHC1that suppresses tumor growth when the expression was restored, but the specific mechanism was yet to be found. The protein product of ZDHHC1is an S-palmitoyltransferase and we have identified p53 as a substrate for ZDHHC1-mediated palmitoylation, specifically at the C135, C176, and C275 residues. The novel form of post-translational modification of p53 is required for the nuclear translocation of the tumor suppressor. p53 recruited DNMT3A to ZDHHC1promoter and is responsible for the hypermethylation of ZDHHC1. The epigenetic feedback loop formed by ZDHHC1 and p53 sheds light on the inactivation of p53 without the presence of genetic mutations.

Published
2021
Full Text
View/download PDF

196. BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1–MCM2 signaling during pregnancy

Author

Xu, Xiaoling, primary, Chen, Eric, additional, Mo, Lihua, additional, Zhang, Lei, additional, Shao, Fangyuan, additional, Miao, Kai, additional, Liu, Jianlin, additional, Su, Sek Man, additional, Valecha, Monica, additional, Chan, Un In, additional, Zheng, Hongping, additional, Chen, Mark, additional, Chen, Weiping, additional, Chen, Qiang, additional, Fu, Haiqing, additional, Aladjem, Mirit I, additional, He, Yanzhen, additional, and Deng, Chu-Xia, additional

Published
2018
Full Text
View/download PDF

197. Cyclin B1 stability is increased by interaction with BRCA1, and its overexpression suppresses the progression of BRCA1-associated mammary tumors

Author

Choi, Eun Kyung, primary, Lim, Jeong-A, additional, Kim, Jong Kwang, additional, Jang, Moon Sun, additional, Kim, Sun Eui, additional, Baek, Hye Jung, additional, Park, Eun Jung, additional, Kim, Tae Hyun, additional, Deng, Chu-Xia, additional, Wang, Rui-Hong, additional, and Kim, Sang Soo, additional

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results