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In this study, the influence of phase change material (PCM) location in a closed display cabinet cooled by a transcritical CO2 refrigeration system was examined experimentally. Two configurations have been investigated where PCM panels are placed on the backside and the shelves of the cabinet. The effect of PCM locations on the cabinet air temperature and compressor power consumption is evaluated and compared during periods of 24 and 8 h of operation. The variation of in the cabinet air temperatures and power consumption with time is measured during charging, running, and power failure periods. It is found that installing PCMs on the shelves of the cabinet is more advantageous and promising in terms of both maintaining cabinet air temperature homogeneous and keeping it at certain average temperature levels. For PCM on the shelves case, energy saving is found 4.4% less than without PCM case. On the other hand, PCM on the backside case results in 8% more energy consumption. Moreover, the running time is found 15.8 less for PCM on the shelves case. Therefore, PCM on shelves case is concluded to be the best option for PCM utilization in the present study. (C) 2020 Elsevier Ltd and IIR. All rights reserved.

Aim: Bloodstream infections are serious conditions that can cause significant morbidity and mortality. Early recognition of the bacteria and targeted early treatment play an important role in prognosis. the Verigene Gram-negative blood culture nucleic acid test (BC-GN; Nanosphere, USA) is a new method that can accurately identify both Gram-negative bacteria and resistance genes within 2 hours. in this study, we aimed to determine the accuracy of this assay for the rapid identification of certain Gram-negative microorganisms in children with bloodstream infections and to compare with the conventional culture method. Materials and Methods: A total of 30 patients (, Ege University Scientific Research FundEge University, This research was supported by Ege University Scientific Research Fund.

In this study, biologically degummed okra bast and corn husk fibers were subjected to alkalization processes. Alkalization treatments resulted in decrease of linear density of the biologically degummed fibers. Increment in alkali concentration resulted in an initial increase then a successive decrease in all tensile indicators: initial modulus, breaking tenacity and breaking elongation. 3 g/L NaOH-treated fibers showed the best tensile characteristics for both okra bast and corn husk fibers. The IR spectra analysis suggested elimination of extracellulosic materials upon alkaline treatment. The ranges for properties of the produced okra bast and corn husk fibers can be summarized in consecutive order as linear density of 9.7-12.3 and 20.0-24.3 tex; initial modulus between 1257-1897 and 156.4-354.6 cN/tex; breaking tenacity range in 28.0-46.8 and 6.37-15.2 cN/tex; and elongation in the range 2.0-2.5% and 8.7-19.9%. The properties of obtained okra bast fibers are found to be superior to corn husk fibers and comparable to that of conventional bast fibers.

Aim: Hyponatremia is a common electrolyte abnormality in hospitalized patients. Administration of isotonic maintenance fluids is recommended to prevent hyponatremia. the present study was conducted to evaluate the frequency and severity of hyponatremia in children with acute lymphoblastic leukemia (ALL). Materials and Methods: the frequency, severity and possible causes of hyponatremia in children with ALL throughout their entire intensive treatment were retrospectively evaluated. All children in this study received isotonic fluids as maintenance IV treatment during the hospitalization period. Results: in a five-year period, 618 hyponatremia episodes seen in 92 children with ALL (median age 59 months), treated with ALLIC 2002 protocol were entered into the study. the median number of hyponatremia episodes per patient was 6. All patients had at least one hyponatremia episode of which 83.2% were classified as mild, 13.2% as moderate, 2.9% as severe and 0.6% as very severe. the median duration of hyponatremia episodes was 5 (range between 1-43) days. the total duration of all hyponatremia episodes of each patient varied from 6 to 138 days with a median of 30 days. in 241 episodes of 68 children, there was inadequate salt intake secondary to oral feeding intolerance, nausea, vomiting and oral aphthous stomatitis. in four patients, seizure was seen during the hyponatremia period and thought to be secondary to hyponatremic encephalopathy. No patient developed central pontine myelinolysis. Conclusion: Hyponatremia is very frequent in ALL patients. Despite the use of isotonic IV fluids, it seems it cannot be completely prevented.

Severe Congenital Neutropenia (SCN) is a rare inherited disease characterized by an absolute neutrophil count (ANC) lower than 500/mu L. Genetic heterogeneity and biallelic CSF3R mutation has rarely been identified as an underlying genetic defect in SCN. the majority of SCN patients respond to granulocyte colony stimulating factor treatment; however, in patients with inherited CSF3R mutation, ANC cannot generally be increased with granulocyte colony stimulating factor treatment. in such cases, granulocyte macrophage colony stimulating factor presents as an effective treatment option. Herein, we report a case of a 5-year-old SCN girl with homozygous c610-611 del ins AG (p.Q204R) mutation in the CSF3R gene, who was successfully treated with granulocyte macrophage colony stimulating factor.

Amaç: Hemofagositik lenfohistiyositoz (HLH) kontrolsüz immün yanıta yol açan hiperinflamasyonla karakterize klinik bir sendromdur. Etiyolojiye bağlı primer ve sekonder olarak sınıflanmaktadır. Klinik bulguları arasında ateş, splenomegali, hepatit yer almaktadır. Tanı doku örneklenmesi ile konulur. Familyal HLH’li hastaların santral sinir sistemi (SSS) tutulumu hastalığın prognozunu ve klinik gidişini olumsuz etkileyen bir faktördür. SSS tutulumunun bulguları; progresif ensefalopati, irritabilite, nöbet, kraniyal sinir paralizisi, ataksi, nistagmus, yürüme ve görme bozukluğu, psikomotor gelişim geriliğidir. Bu çalışmada, SSS tutulumu olan 6 olgunun radyolojik görüntüleme bulgularını sunmayı amaçladık.Gereç ve Yöntem: Bir-onbir yaş aralığında 6 hasta irritabilite, nöbet, ataksi, nistagmus, yürüme ve görme bozukluğu, psikomotor gelişim geriliği gibi nörolojik bulgularla hastanemize baş vurdu ve nörolojik muayene sonrasında kranyal manyetik rezonans görüntüleme (MRG) incelemesi gerçekleştirildi.Bulgular: Hastalarımıza klinik ve laboratuvar değerlendirmeleri sonrasında yapılan kemik iliği biyopsisi ile HLH tanısı konuldu. Hastalarımızın tamamında SSS tutulumunu gösteren kraniyal MRG bulguları saptandı. MRG incelemesinde T2 ağırlıklı ve FLAIR sekanslarında serebral hemisferlerde hiperintens odaklar ve postkontrast serilerde patolojik kontrastlanma ortak bulgular olarak belirlendi.Sonuç: HLH hastalığının santral sinir sistemi tutulumu yüksek mortalite ve morbidite ile seyretmektedir. Kraniyal MRG SSS tutulumunu göstermede önemli rol oynamaktadır., Aim: Hemophagocytic lymphohistiocytosis (HLH) is a clinical syndrome characterized by hyperinflammation causing uncontrolled immune response. It is classified as primary and secondary according to etiology. Fever, splenomegaly, hepatitis are among the clinical findings. The diagnosis is made with tissue sampling. The central nervous system (CNS) involvement of familial HLH patients is a factor that affects the prognosis and course of the disease. The findings of CNS involvement include progressive encephalopathy, irritability, attack, cranial nerve paralysis, ataxy, nistagmus, walking and visual impairment, psychomotor development deficiency. In this study, we aimed at presenting the radiologic imaging findings of 6 cases with CNS involvement.Materials and Methods: Six patients between the ages of 1-11 years applied to our hospital with neurological findings such as irritability, attack, cranial nerve paralysis, ataxy, nistagmus, walking and visual impairment, psychomotor development deficiency. Following the neurological examination, the cranial magnetic resonance imaging (MRI) examination was conducted.Results: HLH diagnosis was made through bone marrow biopsy after clinical and laboratory evaluations. Cranial MRI findings indicating CNS involvement were observed in all of our patients. Hyperintense foci in cerebral hemispheres and pathological contrast enhancement in postcontrast series were defined in T2 and FLAIR sequences in MRI examination.Conclusion: The central nervous system involvement of HLH disease is observed with high mortality and morbidity. Cranial MRI plays a significant role in revealing CNS involvement.

A novel ratiometric colorimetric and fluorescent dual probe based on Eriochrome Black T (EBT)-Eu3+ complex was designed to detect dipicolinic acid (DPA), a major constituent of bacterial spores, with high sensitivity and selectivity. UV-vis titration experiments demonstrated that EBT and Eu3+ ions formed a 1:1 coordination pair in water. In the presence of Eu3+ ions, the blue solution of EBT changed to magenta, however, upon the addition of DPA, the magenta color changed to blue immediately and characteristic fluorescence emission from DPA-Eu3+ complex was observed. In addition, the sensitivity of the system was further evaluated on Geobacillus stearothermophilus spores and as low as 2.5 × 105 spores were detected.

Background: Polycystic ovary syndrome is the most frequently seen endocrine disorder in women of reproductive age with a prevalence of about 10%.Aims: To investigate the efficiency of growth differentiation factor 9 and bone morphogenetic protein 15 during folliculogenesis in a dehydroepiandrosterone-induced mouse Polycystic ovary syndrome model.Study Design: Animal experimentation.Methods: Mice were divided into 3 groups: control, vehicle and Polycystic ovary syndrome. Polycystic ovary syndrome model mice were developed by the injection of dehydroepiandrosterone dissolved in 0.1 mL of sesame oil. Ovarian tissues were examined for growth differentiation factor 9 and bone morphogenetic protein 15 using immunofluorescent labelling and electron microscopic examinations.Results: The immunoreactivity of growth differentiation factor 9 and bone morphogenetic protein 15 proteins decreased (p

nofulltext# --- Yılmaz, Deniz (Arel Author), Passive cooling covers the natural processes of heat dissipation and heat gain operations and provides a highly efficient, comfortable environment around. As commonly known, when air is heated, it rises, when cooled, it descends. Natural cooling and heating use this physical property of air to provide the best thermal conditions. In this study, an air-to-water heat pump system used for chilled ceiling operations was analyzed numerically and experimentally. Main objective of this study is to obtain COP of the heat pump system. In order to determine the efficiency, test room was established with heat pump-driven passive chilled ceiling panels. The test room was constructed of 120-mm polyurethane panels to minimize heat losses. All the data obtained from the system is recorded on a time period of per-second based during the processes.

Made available in DSpace on 2022-04-28T19:41:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 European Regional Development Fund Water-repellent soils usually experience water flow impedance during the early stage of a wetting process followed by progressive increase of infiltration rate. Current infiltration models are not formulated to describe this peculiar process. Similarly, simplified methods of soil hydraulic characterization (e.g., BEST) are not equipped to handle water-repellent soils. Here, we present an adaptation of the BEST method, named BEST-WR, for the hydraulic characterization of soils at any stage of water-repellency. We modified the Haverkamp explicit transient infiltration model, included in BEST for modeling infiltration data, by embedding a scaling factor describing the rate of attenuation of infiltration rate due to water repellency. The new model was validated using analytically generated data, involving soils with different texture and a dataset that included data from 60 single-ring infiltration tests. The scaling factor was used as a new index to assess soil water repellency in a Mediterranean wooded grassland, where the scattered evergreen oak trees induced more noticeable water repellency under the canopies as compared to the open spaces. The new index produced results in line with those obtained using the water drop penetration time test, which is one of the most widely test applied for quantifying soil water repellency persistence. Finally, we used BEST-WR to determine the hydraulic characteristic curves under both hydrophilic and hydrophobic conditions. Department of Agricultural Sciences University of Sassari, Viale Italia, 39A Université de Lyon UMR5023 Ecologie des Hydrosystèmes Naturels et Anthropisés CNRS ENTPE Université Lyon 1 School of Plant and Environmental Sciences Virginia Polytechnic Institute and State University Department of Land Air and Water Resources University of California Department of Architecture Design and Urban Planning University of Sassari, Viale Piandanna, 4 School of Agriculture São Paulo State University (UNESP) Fazenda Experimental Lageado Civil Engineering Department Engineering Faculty Munzur University School of Agriculture São Paulo State University (UNESP) Fazenda Experimental Lageado

BACKGROUND: Postural control allows performance of daily and sports activities. The previous studies show that postural sway inceases in orthopaedic injuries such as osteoarthritis and total knee arthroplasty. OBJECTIVE: To compare postural sway, risk of falling and function between individuals with and without patellofemoral pain syndrome (PFS). METHODS: This study included 22 subjects with patellofemoral pain syndrome, age-matched pain-free 22 females serving as a control group. Visual anolog scale and Kujala were used to evaluate the pain. Posturographic assesment was performed by Tetrax posturographic device. Biering Modified Sorenson test for extensor endurance and sit-up test for flexor endurance were used for the evaluation of trunk endurance. Timed get-up and go test was used for lower extremity function. The Student's t Test was used to compare variables between the groups. The Pearson correlation coefficients were calculated to examine correlation between the quantitative variables. RESULTS: Postural sway included eyes open without pillow, eyes open on pillow, eyes closed on pillow, risk of falling, function and postural stabilization included flexor endurance, extansor endurance are impared in patient with patellofemoral pain syndrome when compare to controls. In subjects with PFPS increased postural sway significantly associated with body mass index (r= 0.52), pain duration (r= 0.43), postural control (extansor endurance) (r= -0.50) and risk of falling (r= 0.62) on pillow with open eyes. In addition we found function significantly related with postural control (extansor endurance and flexor endurance) (r= -0.59 and r= -0.59) and risk of falling (r= 0.77) CONCLUSIONS: Decreased neuromuscular control of the trunk core and increased postural sway and falling risk were found in patients with PFPS. Patients may be evaluated for deficits in postural control and falling risk before treatment. Language: en

Soğutma sistemleri çalışılmak istenen soğutma sıcaklığına bağlı olarak çeşitli kategorilere ayrılmaktadır. -50°C ve -100°C sıcaklık aralığında gerçekleştirilen soğutma işlemleri ultra düşük sıcaklık uygulaması sınıfına girmektedir. Soğutma sistemleri; kompresör sıkıştırma oranı, dış hava sıcaklıkları ve kullanılan akışkan özellikleriyle sınırlandırıldığından dolayı bu sıcaklık değerlerini tek kademeli bir soğutma sistemiyle elde edebilmek çok zordur. Bu sebeple iki kademeli soğutma sistemleri kullanılmaktadır. Bu sistemlerin yüksek sıcaklık çevrimlerinde R134a, R404A ve R507A gibi akışkanlar; düşük sıcaklık çevriminde ise R23, R503 ve R508B gibi akışkanlar kullanılabilmektedir. Bu çalışmada, yüksek sıcaklık çevriminde R404A; düşük sıcaklık çevriminde ise R508B akışkanının kullanıldığı iki kademeli bir soğutma sistemi termodinamik olarak incelenmiştir. EES (Engineering Equation Solver) yazılımı kullanılarak ultra düşük oda sıcaklıklarında çalışan bir soğutma sistemine ait ekipmanların enerji ve ekserji analizi yapılmış ve sonuçlar irdelenmiştir. Gerçekleştirilen çalışmada kaskat ısı değiştiricisindeki buharlaşma sıcaklığının artışı sistem performansını arttırmakta kaskat ısı değiştiricisindeki sıcaklık farkının artışının ise performans değerini azalttığı görülmüştür. Sistem performansının ise -30 oC ile -35 oC arasındaki kaskat ısı değiştirici buharlaşma sıcaklığında azami değerine ulaştığı sonucuna varılmıştır. Refrigeration systems can be categorized according to the refrigeration temperature needed. The systems operating at the temperatures between -50°C and -100°C are classified as the ultra-low temperature refrigeration systems. Since the parameters such as compression ratio, ambient air temperature and refrigerant properties limit the operation of refrigeration system, it is difficult to obtain these operating temperatures with a single-stage refrigeration system. Therefore, double-stage, cascade, ones are preferred for this purpose. While refrigerants such as R134a, R404A, and R507A are used at the high temperature cycle of cascade systems, R23, R503 and R508B can be used at the low temperature cycles. In this study, a cascade refrigeration system with R404A at the high temperature and R508B at the low temperature cycle is thermodynamically analyzed. Using Energy Equation Solver (EES) software, energy and exergy analysis of the equipments of a system operating at ultra-low temperatures were performed and the results were investigated for different operating conditions. In this study; increasing evaporation temperature in the cascade heat exchanger has an increasing effect on system performancei nevertheless increasing temperature difference in cascade heat exchanger has an decreasing effect on system performance. Coefficient of performance has a maximum value between -30 oC and -35 oC cascade evaporation temperatures.

Ekolojik sistem yaklaşımı, bireyi, çevresi içerisinde yaşayan bir varlık olarak ele alır ve bireyin davranışını değerlendirirken bu çevreyi de göz önünde bulundurur ve sorunun çözümüne bu noktadan hareketle başlar. Bu çalışmada, bir bakkal dükkanından hırsızlık yaptığı gerekçesiyle ilgili mahkemece hakkında Danışmanlık Tedbiri kararı verilen 16 yaşında bir erkek çocuğu ile yapılan mesleki çalışmada Ekolojik Sistem yaklaşımı kullanılmıştır. Buna göre, çocuk, içinde bulunduğu sistem içerisinde değerlendirilmiş ve her bir sistemin değiştirilmesi yoluna gidilerek çocuğun sorunlu davranışlarının düzeltilmesi sağlanmıştır.

WOS: 000390182600053 PubMed: 27852519 Gold nanoparticles (GNPs) functionalized with ethylenediamine-lanthanide complexes (Eu-GNPs and Tb-GNPs) were usedfor the selective fluorescent detection of dipicolinic acid (DPA), a unique biomarker of bacterial spores, in water. Particles were characterized by transmission electron microscopy and zeta potential measurements. The coordination of DPA to the lanthanides resulted in the enhancement of the fluorescence. A selective response to DPA was observed over the nonselective binding of aromatic ligands. The ligand displacement strategy were also employed for the ratiometric fluorescent detection of DPA. 4,4,4-trifluoro-1-(2-naphthyl)-1,3-butanedion (TFNB) was chosen as an antenna to synthesize ternary complexes. The addition of DPA on EuGNP:TENB ternary complex quenched the initial emission of the complex at 615 nm and increased the TFNB emission at 450 nm when excited at 350 nm. The results demonstrated that the ratiometric fluorescent detection of DPA was achieved by ligand displacement strategy. (C) 2016 Elsevier B.V. All rights reserved. Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114Z088] This research was financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK), Project No: 114Z088 which is gratefully acknowledged here.

WOS: 000396430900009, PubMed ID: 28002785, Turkey has experienced a wave of demonstrations in the summer of 2013, called Gezi Park Demonstrations. Between 31 May and 30 August, 297 people who had been subjected to trauma by several methods of demonstration control and Riot Control Agents applied to the Human Rights Foundation of Turkey Rehabilitation Centers to receive treatment/rehabilitation and/or documentation. 296 patients except one 5-year-old child were included in the study. Of the 296 patients; 175 were male, 120 were female, and one was a transgender individual. The highest number of applications was received by the Istanbul center with 216 patients. The mean age of applicants was 33.85, and the age range was 15-71 years. While 268 of applicants (91%) stated that they had been exposed to Riot Control Agents, 62 patients suffered only chemical exposure who had no other traumatic injuries whereas 234 patients suffered at least one blunt trauma injury. Blunt trauma injuries are due to being shot by gas canisters in 127 patients (43%), by plastic bullets in 31 patients (10%). 59 patients (20%) were severely beaten, and 30 patients (10%) were injured by pressurized cold water ejected by water cannons. Thirteen patients (4.4%) suffered injuries that caused loss of vision or eye. Psychiatric evaluations were carried out for 117 patients while 43% of them were diagnosed with Acute Stress Disorder. Post Traumatic Stress Disorder and Major Depressive Disorder followed this diagnosis. This study includes the medical evaluation of injuries allegedly sustained during Gezi Park demonstrations in 2013 as a result of several methods of demonstration control and/or by being exposed to Riot Control Agents. The aim is to discuss different types of injuries due to those methods and health consequences of Riot Control Agents. (C) 2016 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved.

WOS: 000396425800003, PubMed ID: 27815226, Objectives: Invasive aspergillosis (IA) is an important cause of mortality and morbidity in children with hematological malignancies. The monitoring of serum galactomannan (GM) antigen is considered useful in the diagnosis of IA. The aim of this study was to determine the utility of serum GM monitoring in the early diagnosis of IA and the role of positive antigenemia in the management of children with acute lymphoblastic leukemia (ALL). Methods: The cases of 141 children who were being treated for ALL in the Division of Pediatric Hematology of the Medical School of Ege University between January 2006 and February 2015 were reviewed retrospectively. Cases of proven and probable IA were defined according to the European Organization for the Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria. Results: The incidence of proven and probable IA was 3.5% (5/141). The incidence of positive GM antigenemia among 3264 serum samples was 5.5% (n = 179). Of the cases detected, 21.7% were truepositive, 52.1% were false-positive, and the remaining 26.1% were classified as 'undetermined.' An increase in the incidence of true-positive tests and induction of antifungal therapy was determined through multiple consecutive positive tests. Conclusions: GM may be detected in the serum before the clinical signs of IA appear, but its sensitivity and specificity are variable. False-positivity is a significant disadvantage, and consecutive positive GM must be taken into account in the case of clinical and imaging findings that are relevant to IA. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

Introduction: Growth retardation (GR) and pubertal disturbances are the earliest consequences of iron toxicity resulting from the pituitary iron deposition in children and adolescents with thalassemia major (TM). It is suggested that adequate transfusion regimens together with appropriate management of iron chelation with timely initiation and dose tailoring by close monitoring using surrogate markers of the iron load may achieve a normal pattern of complication-free survival in TM. Objectives: The purpose of this study was to evaluate the fact that the current approach to the management of the disease has provided a normal growth progression and sexual development in patients (pts) with TM. Methods: We recruited male (M) and female (F) TM pts born after 2000 and followed-up (FU) in Ege University Thalassemia Center. The pts. with an acute or chronic illness that may interfere with growth and development or stem cell transplantation recipients were excluded. The Committee of Clinical Investigation at Ege University Hospital (19.02.2020, 20-2.1T/2) approved this study. Height (H) and weight (W) assessments were performed by using the Harpenden stadiometer and puberty was evaluated by Tanner staging at 3 monthly intervals. H-standard deviation scores (h-SDS) were calculated. Target-H based on mid-parental-H for M & F pts was estimated. All pts. were evaluated annually for bone mineral density (BMD) using dual-energy X-ray absorptiometry (Hologic QDR-4500W, USA) after 8 years (y) of age. The mean SDS of the lumbar spine (L1-4) BMD between -1 and -2.5 was defined as osteopenia and Transfused pRBC units (U) and average pre-transfusion hemoglobin (Hb) per year were recorded. Serum ferritin (SF) was monitored at monthly intervals. Myocardial (T2*) and liver (R2) iron were assessed by a 1.5 Tesla magnetic resonance imaging (MRI) machine (Siemens, Symphony Vision 16034 scanner) after 8 y. Annual median SF, prescribed chelator(s), mean chelator doses were recorded by reviewing pts' records. Transfusional iron intake (TII) was estimated as the total amount of pure RBCs (each U, 250 ml with 57% Hct) transfused in a y (ml) x 1.08. Daily TII was expressed as annual TII (mg)/ mean kg b.w./days of the y. Results: We recruited 30 TM (28 β/β, 1 β/δβ, and 1 non-deletional HbH) pts (13 F and 17 M). Demographics for the population are summarized in Table1. All pts maintained annual mean pre-transfusion Hb> 9 g/dl. Twenty-two of 24 pts maintained Deferasirox (DFX) chelation during 9 ± 3.6 y (median 9, range 2-13 y) and achieved optimum SF levels at all times (Figure a). The dose tailoring of DFX found parallel to the changes in TII during FU (Figure b). Liver iron concentration (LIC) and myocardial T2* (mT2*) in 22 pts on DFX chelation were between 0.9-5.4 (2.1 ± 1.3 SD) mg Fe/g d.w. and 19.4-43.5 (28 ± 6.7 SD) ms, respectively, in all assessments. The only pt with mT2* of 19.4 ms revealed mT2* of >20 ms on FU scans. The puberty initiated at 12.8 ± 1.1 y in M (n=12) & 11.2 ± 1.3 y in F (n=12) and progressed without hormone replacement in all, regardless of the chelator. Overall, growth reduced compared to the non-thalassemic population after 8 y with clear evidence of growth catch-up by the introduction of puberty. h-SDS detected Conclusions: Puberty was the main determinant of growth and bone maturation in TM. Despite, puberty has achieved within physiological limits in M & F pts, a slight delay was observed compared to the non-thalassemic population. The relative delay in pubertal spurt may lead to overdiagnosis of growth and bone-maturation failure and unnecessary intervention in adolescent TM pts. This hypothesis as well as the appropriateness of current management guidelines remains to be elucidated. Disclosures No relevant conflicts of interest to declare.

Herein, we report the synthesis of silver nanoparticles (AgNPs) by a green route using the aqueous leaf extract of Morus indica L. V1. The synthesized AgNPs exhibited maximum UV-Vis absorbance at 460 nm due to surface plasmon resonance. The average diameter (~54 nm) of AgNPs was measured from HR-TEM analysis. EDX spectra also supported the formation of AgNPs, and negative zeta potential value (−14 mV) suggested its stability. Moreover, a shift in the carbonyl stretching (from 1639 cm−1 to 1630 cm−1) was noted in the FT-IR spectra of leaf extract after AgNPs synthesis which confirm the role of natural products present in leaves for the conversion of silver ions to AgNPs. The four bright circular rings (111), (200), (220) and (311) observed in the selected area electron diffraction pattern are the characteristic reflections of face centered cubic crystalline silver. LC-MS/MS study revealed the presence of phytochemicals in the leaf extract which is responsible for the reduction of silver ions. MTT assay was performed to investigate the cytotoxicity of AgNPs against two human cell lines, namely HepG2 and WRL-68. The antibacterial study revealed that MIC value of the synthesized AgNPs was 80 µg/ml against Escherichia coli K12 and Staphylococcus aureus (MTCC 96). Finally, the synthesized AgNPs at 10 µg/ml dosages showed beneficial effects on the survivability, body weights of the Bombyx mori L. larvae, pupae, cocoons and shells weights via enhancing the feed efficacy.

Objective: In recent years, the rates of marriage and pregnancy are increasing in patients with thalassemia major. The aim of the present study was to investigate the fertility rate of thalassemic patients and the course of pregnancies in terms of mother and infant health. Materials and Methods: In this observational study patients with major hemoglobinopathy were evaluated regarding marital status, the need for assisted reproductive techniques, fertility rate, iron status, and pregnancy complications. Results: Seventeen female patients gave birth to 21 healthy infants. About one-third of the patients needed assisted reproductive techniques. Thalassemia major patients showed increased serum ferritin levels from 1203±1206 µg/L at baseline to 1880±1174 µg/L at the end of pregnancy. All babies are still alive and healthy. Conclusion: Pregnancy in patients with thalassemia can be safe for the mother and newborn with close monitoring and a multidisciplinary approach., Amaç: Son yıllarda, talasemi majör olgularının evlilik ve gebelik oranları giderek artmaktadır. Bu çalışmanın amacı, talasemi hastalarının fertilite oranlarının araştırılması ve anne ve bebek sağlığı açısından gebelik sonuçlarının değerlendirilmesidir. Gereç ve Yöntemler: Bu gözlemsel çalışmada; majör hemoglobinopatili hastalar; evlenme ve çocuk sahibi olma oranları, yardımcı üreme tekniklerine gereksinimleri, demir statüleri ve gebelik komplikasyonları açısından değerlendirilmiştir. Bulgular: On yedi talasemik kadın hasta, toplam 21 sağlıklı bebek doğurmuştur. Hastaların üçte biri bebek sahibi olabilmek için yardımcı üreme tekniğine ihtiyaç duymuştur. Talasemi majör olgularının serum ferritin değerleri hamileliğin başında ortalama 1203±1206 ug/L saptanmış olup, hamileliğin sonunda 1880±1174 ug/L seviyesine yükselmiştir. Tüm bebekler halen hayatta ve sağlıklıdırlar. Sonuç: Talasemi olgularında hamilelik süreci yakın takip ve multidisipliner yaklaşım ile beraber güvenli olarak geçirilebilecektir.

Aim: Pancytopenia is a clinical problem which has a wide differential diagnostic spectrum and may occur with various mechanisms. In this study we aimed to determine the most common etiologic causes in patients with pancytopenia. Materials and Methods: The records of patients aged 18 years and older, who applied to the Health Sciences University Bakirkoy Dr. Sadi Konuk Training and Research Hospital between 2012 and 2017 and who were diagnosed with pancytopenia according to World Health Organization (WHO) criteria were retrospectively reviewed. Statistical Method: Mann-Whitney-U test was used for 2 groups and Kruskal-Wallis test was applied for 3 and more groups. Since no normal distribution was provided as a descriptive statistic, median and change interval values were given for continuous data. Results: A total of 766 patients, 475 (62%) women and 291(38%) men, were included in the study. In these patients, non-hematologic causes were found in 77.7% and hematologic causes in 22.3% of patients with pancytopenia. Hematological etiologies were 72.2% benign and 27.8% malignant. Non-hematological causes were divided into groups as renal diseases (6.05%), rheumatological diseases (2.3%), infective diseases (10.7%), endocrinological diseases (3.8%), hypersplenism (14.4%), immunosuppressive drug use (17.4%), solid organ cancers (10.7%) and unidentified reasons (34.2%). Conclusion: Pancytopenia should be evaluated carefully and the etiology should be detected quickly and corrected by appropriate treatment. It is an appropriate approach to exclude, firs the non-hematological causes (especially immunosuppressive drug use, hypersplenism, infection and solid organ cancers) and the benign causes of hematological reasons., Amaç: Pansitopeni, çeşitli mekanizmalarla ortaya çıkabilen ve geniş bir ayırıcı tanı spektrumuna sahip klinik bir problemdir. Bu çalışmada pansitopenili hastalarda en sık görülen etiyolojik nedenleri belirlemeyi amaçladık. Gereç ve Yöntem: Sağlık Bilimleri Üniversitesi Bakırköy Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi’ne 2012-2017 yılları arasında başvuran ve Dünya Sağlık Örgütü kriterlerine göre pansitopeni tanısı alan 18 yaş ve üstü hastaların kayıtları retrospektif olarak incelendi. İstatistiksel Yöntem: İkili gruplara Mann-Whitney-U testi, 3 ve daha fazla grubun olduğu karşılaştırmalarda ise Kruskal-Wallis testi uygulandı. Tanımlayıcı bir istatistik olarak normal dağılım sağlanmadığından, sürekli veriler için ortanca ve değişim aralığı değerleri verildi. Bulgular: Çalışmaya 475 (%62) kadın ve 291 (%38) erkek olmak üzere toplam 766 hasta dahil edildi. Bu hastaların %77,7’sinde hematolojik olmayan nedenler, %22,3’ünde ise hematolojik nedenlerin pansitopeni etiyolojisinde rol oynadığı görüldü. Hematolojik etiyolojilerin %72,2’si benign, %27,8’i ise malign hastalıklardan oluşmaktaydı. Hematolojik olmayan nedenlerin ise; renal (%6,05), romatolojik hastalıklar (%2,3), enfektif hastalıklar (%10,7), endokrinolojik hastalıklar (%3,8), hipersplenizm (%14,4), immünsupresif ilaç kullanımı (%17,4), solid organ kanserleri (%10,7) ve tanımlanamayan nedenler (%34,2)’den oluştuğu görüldü. Sonuç: Pansitopeni dikkatlice değerlendirilerek etiyolojisi hızlı bir şekilde tespit edilmeli ve uygun tedavi ile düzeltilmelidir. Öncelikle hematolojik olmayan nedenlerin (özellikle immünsupresif ilaç kullanımı, hipersplenizm, enfeksiyon ve solid organ kanserleri) ve hematolojik nedenlerden de benign hastalıkların dışlanması uygun bir yaklaşımdır.

While Timber–Concrete Composite (TCC) construction has been intensively studied in terms of structural behaviour, there is little research on the risk of corrosion of the used metallic shear fasteners in different exposure environments. Due to the marked differences in chemical environments of wood and concrete, however, it can be expected that the fasteners are subject to galvanic corrosion. This was experimentally studied in the present work. TCC specimens were fabricated for electrochemical testing and exposed to two different exposure environments, that is, 95% relative humidity and immersion in water. The moisture content in the wood, the difference in electrochemical potentials and the galvanic current were monitored over 2 months. Two types of fasteners were tested, namely zinc galvanized steel fasteners as well as browned fasteners that have been widely used in the TCC construction industry since 2013. It was found that the fastener parts in the wood generally act as an anode, while the remaining parts in the concrete act as a cathode. However, significant galvanic currents were only observed upon immersion in water. For practical applications in structural engineering, it is concluded that the mass loss of metal of the studied fasteners cannot present a severe risk for structures, especially not at the service classes 1 and 2 according to EN 1995-1-1.

EgeUn###, Background:Invasive fungal infections, including hepatosplenic fungal infections (HSFI), cause significant morbidity and mortality in children with leukemia. There are not enough data to support for the best approach to diagnosis of HSFI in children, nor for the best treatment.Procedure:In this multicentric study, we assessed the demographic data, clinical and radiologic features, treatment, and outcome of 40 children with leukemia and HSFI from 12 centers.Results:All cases were radiologically diagnosed with abdominal ultrasound, which was performed at a median of 7 days, of the febrile neutropenic episode. Mucor was identified by histopathology in 1, and Candida was identified in blood cultures in 8 patients. Twenty-two had fungal infection in additional sites, mostly lungs. Nine patients died. Four received a single agent, and 36 a combination of antifungals.Conclusions:Early diagnosis of HSFI is challenging because signs and symptoms are usually nonspecific. In neutropenic children, persistent fever, back pain extending to the shoulder, widespread muscle pain, and increased serum galactomannan levels should alert clinicians. Abdominal imaging, particularly an abdominal ultrasound, which is easy to perform and available even in most resource-limited countries, should be recommended in children with prolonged neutropenic fever, even in the absence of localizing signs and symptoms. © 2018 Wolters Kluwer Health, Inc. All rights reserved.

This paper presents the results of an investigation on internal stress progression and the explicit dynamics simulation of the bruising behavior of potato tubers under dynamic mechanical collision. Physical measurements, mechanical tests, advanced solid modeling, and engineering simulation techniques were utilized in the study. The tuber samples used in the simulation were reverse engineered and finite element analysis (FEA) was set up to simulate the collision-based bruising behavior of the potato tubers. The total number of identical tuber models used in the simulation was 17. The numerical data of the FEA results revealed useful stress distribution and mechanical behavior visuals. These results are presented in a frame that can be used to describe bruise susceptibility value on potato-like agricultural crops. The modulus of elasticity was calculated from compression test data as 3.12 MPa. Structural stresses of 1.40 and 3.13 MPa on the impacting (hitting) and impacted (hit) tubers (respectively) were obtained. These stress values indicate that bruising is likely to occur on the tubers. This research paper provides a useful how-to-do strategy to further research on complicated bruising investigations of solid-like agricultural products through advanced engineering simulation techniques. Practical applications: This research aims to simulate realistic dynamic deformation of potato tubers during mechanical collision, which is very hard to achieve through physical or analytical expressions. This is attractive because related food processing industries have shown their interest in determining the physical properties and bruising behavior of food/agricultural products using experimental, numerical, and engineering simulation methods so that it can be used in their food processing technology. Very limited data have been found available in the literature about the subject of FEM-based explicit dynamics simulation of solid-like agricultural crops such as the self-collision case of potato tubers (which is very important for indoor or outdoor potato processing). Comparative investigations on determination of modulus of elasticity are very limited as well. Most of the research focused on single calculation theory and linear static loading assumption-based FEM simulation solutions. Here, we report a “how-to-do” case study for dynamic self-collision simulation of potato tubers.

International audience

"Objectives: The aims of this study were to translate the Pelvic Girdle Questionnaire (PGQ) to Turkish and to assess its test-retest reliability and validity in pregnant women. Materials and Methods: One hundred and thirty-five pregnant with pelvic girdle pain were recruited in the study. Visual analog scale was used to evaluate pain intensity, PGQ for condition-specific health related quality of life, Nottingham Health Profile for health-related quality of life, Oswestry Disability Index for disability level, The guidelines for cross-cultural adaptation in PGQ was used. Results: A total of 135 pregnant with a mean age of the 30±4.77 years included in the study. Interclass correlation coefficient score for test-retest reliability was 0.972 (95% CI= 0.968-0.977) for PGQ activity subscale, 0.910 (95% CI=0.905-0.915) for PGQ symptom subscale and 0.979 (95% CI= 0.975-0.983) for PGQ total. Conclusion: The study demonstrated that Turkish version of PGQ is a valid and reliable tool for measuring both disability and symptom and good psychometric properties in Turkish speaking pregnants with pelvic girdle pain." Amaç: Bu çalışmanın amacı gebe kadınlarda Pelvik Kuşak Anketi'ni (PKA) Türkçe'ye çevirmek ve testtekrar test güvenilirliği ve geçerliğini değerlendirmekti. Materyal ve Metot: Çalışmaya pelvik kuşak ağrısı olan 135 gebe alındı. Ağrı şiddetini değerlendirmek için görsel analog skalası, duruma özel sağlık ile ilgili yaşam kalitesine için PKA, sağlıkla ilgili yaşam kalitesi için Nottingham Sağlık Profili, özürlülük düzeyi için Oswestry Özürlülük İndeksi, PKA'da kültürlerarası uyum için kılavuzlar kullanılmıştır. Bulgular: Çalışmaya yaş ortalaması 30 ± 4,77 olan 135 gebe dahil edildi. Test-tekrar test güvenirliği için sınıflar arası korelasyon katsayısı puanı, PKA aktivite alt boyutu için 0,972 (% 95 CI = 0,968-0,977), PKA semptom alt boyutu için 0,910 (% 95 CI = 0,905-0,915) ve PKA toplam için 0,979 (% 95 CI = 0,905-0,915) olarak bulundu. Sonuç: Çalışma, pelvik kuşak ağrısı olan Türkçe konuşan gebelerde PKA'nin Türkçe versiyonunun hem sakatlığı hem de semptomu ölçmek için geçerli ve güvenilir bir araç olduğunu ve iyi psikometrik özelliklere sahip olduğunu göstermiştir.

Objectives: The psychosocial factors that may affect the prognosis of patients with low back pain are generally disregarded. The StarT Back Screening Tool can help clinicians to analyze prognostic indicators and the risk associated with outcome by examining physical and psychosocial factors. The aim of this study was to investigate the psychometric properties of the Turkish version of the StarT Back Screening Tool, including cross-cultural adaptation, internal consistency, test-retest reliability, and construct validity. Methods: In this study, 120 patients with non-specific low back pain were included. The Roland Morris Disability Questionnaire, Oswestry Disability Index, Beck Depression Inventory, Tampa Scale for Kinesiophobia, and the StarT Back Screening Tool were administered. One week after the initial testing, the same examiner repeated the tests. Results: The mean age of the patients who participated in the study was 35.54 +/- 12.45 years. Cronbach's alpha coefficients in the analysis of scale reliability were 0.747 for the overall scale and 0.738 for the psychosocial subscale. The test-retest reliability of StarT Back Screening Tool (intraclass correlation coefficient: 0.90-0.93) was found to be excellent. Pearson correlation coefficients for the correlations between the overall StarT Back Screening Tool and the other measures were very good (r=0.678; p

Background Severe congenital neutropenia is a rare disease, and autosomal dominantly inherited ELANE mutation is the most frequently observed genetic defect in the registries from North America and Western Europe. However, in eastern countries where consanguineous marriages are common, autosomal recessive forms might be more frequent. Method Two hundred and sixteen patients with severe congenital neutropenia from 28 different pediatric centers in Turkey were registered. Results The most frequently observed mutation was HAX1 mutation (n = 78, 36.1%). A heterozygous ELANE mutation was detected in 29 patients (13.4%) in our cohort. Biallelic mutations of G6PC3 (n = 9, 4.3%), CSF3R (n = 6, 2.9%), and JAGN1 (n = 2, 1%) were also observed. Granulocyte colony-stimulating factor treatment was given to 174 patients (80.6%). Two patients died with infectious complications, and five patients developed myelodysplastic syndrome/acute myeloblastic leukemia. The mean (+/- mean standard error) follow-up period was 129.7 +/- 76.3 months, and overall survival was 96.8% (CI, 94.4-99.1%) at the age of 15 years. In Turkey, severe congenital neutropenia mostly resulted from the p W44X mutation in the HAX1 gene. Conclusion In Turkey, mutation analysis should be started with HAX1, and if this is negative, ELANE and G6PC3 should be checked. Because of the very high percentage of consanguineous marriage, rare mutations should be tested in patients with a negative mutation screen.

Balıkesir Üniversitesi, Sağlık Bilimleri Enstitüsü, Beden Eğitimi ve Spor Ana Bilim Dalı, Kronotip, yatma zamanı, uyanma ve diğer günlük aktivitelerle ilişkili sirkadiyen ritim (karanlık/ışıl dögüsü) özelliklerini belirleyen bireysel bir özelliktir. Bu araştırmanın amacı, sirkadiyen ritimlere göre, Balıkesir Üniversitesi öğrencilerinde zamanı kullanım performansını ve kronotipi değerlendirmektir. Çalışmaya farklı fakülte ve okullardan toplam 1.366 (764 erkek ve 602 kadın, 18 yaş ve üzeri ) öğrenci katıldı. Kronotipin belirlenmesinde “İnsan Sirkadiyen Ritminde Sabahçıl ve Akşamcıl Tipleri Belirleme Ölçeği” (SATBÖ) Türkçe versiyonu ve hazırlanan kişisel bilgi formu kullanıldı. SATBÖ puanlarına göre, öğrencilerin büyük çoğunluğu %64.7 si aratip, %16.5’i sabahçıl tipe yakın /sabahçıl, %18.8’i akşamcıl tipe yakın/akşamcıl olarak sınıflandırıldı. Kronotip puanları karşılaştırıldığında cinsiyet arasında anlamlı farklılık olmadığı gözlemlenmiştir (p>0.05). 23 yaş ve üstü katılımcılar, genç yaş grubuyla (17-18 yaş) karşılaştırıldığında SATBÖ puanları anlamlı olarak daha yüksek olduğu tespit edilmiştir (p, A chronotype is an individual trait that determines circadian rhythm (dark/light cycle) characteristics, associated with bedtime, waking, and other daily activities. The purpose of this study was to evaluate time management performance and chronotypes of the Balıkesir University students, according circadian rhythms. A total of 1,366 (764 male and 602 female, ages 17-23 years) students from different faculties and schools participated in this study. Chronotype was assessed by Turkish version of the Morningness-Eveningnes Questionnaire (MEQ) and the other questionnaire prepared to assess of personal information of participants were used. According to MEQ, majority of the students were classified as an 64.7% intermediate type, 16.5% moderately morning/morning type, 18.8% moderately evening/evening type. When comparing total chronotype scores with gender, no significant differences were observed (p>0.05). The participants ages 23 years to older groups were more higher MEQ scores compare to younger age groups (age 17-18 years) (p

WOS: 000478208700001, PubMed ID: 31321910, Background Severe congenital neutropenia is a rare disease, and autosomal dominantly inherited ELANE mutation is the most frequently observed genetic defect in the registries from North America and Western Europe. However, in eastern countries where consanguineous marriages are common, autosomal recessive forms might be more frequent. Method Two hundred and sixteen patients with severe congenital neutropenia from 28 different pediatric centers in Turkey were registered. Results The most frequently observed mutation was HAX1 mutation (n = 78, 36.1%). A heterozygous ELANE mutation was detected in 29 patients (13.4%) in our cohort. Biallelic mutations of G6PC3 (n = 9, 4.3%), CSF3R (n = 6, 2.9%), and JAGN1 (n = 2, 1%) were also observed. Granulocyte colony-stimulating factor treatment was given to 174 patients (80.6%). Two patients died with infectious complications, and five patients developed myelodysplastic syndrome/acute myeloblastic leukemia. The mean (+/- mean standard error) follow-up period was 129.7 +/- 76.3 months, and overall survival was 96.8% (CI, 94.4-99.1%) at the age of 15 years. In Turkey, severe congenital neutropenia mostly resulted from the p W44X mutation in the HAX1 gene. Conclusion In Turkey, mutation analysis should be started with HAX1, and if this is negative, ELANE and G6PC3 should be checked. Because of the very high percentage of consanguineous marriage, rare mutations should be tested in patients with a negative mutation screen., Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK); Turkish Pediatric Hematology Association, This study was supported by Scientific and Technological Research Council of Turkey (TUBITAK) and the Turkish Pediatric Hematology Association.

The concentration of nitrite (NO2−) ions above allowable limits in water resources and food stuffs is considered hazardous and has been proven to be of great threat to the environment and public health. In this work, an acenaphtho [1,2-d] imidazole derivative (1) as a ratiometric colorimetric probe is developed. UV–Vis experiments demonstrate that the probe 1 shows excellent selectivity toward NO2− in the presence of other potential interfering species, a rapid response (20 s) and a low detection limit (100 nM) by a distinct visual color change with a bathochromic shift of 120 nm from colorless to intense yellow. Besides, this probe is further used for the quantification of nitrite ions in environmental water resources such as tap water, underground water, and surface water samples. The high recoveries (96–99% with relative standard deviations (RSD) of

Quercetagetin (3,3ʹ,4ʹ,5,6,7-hexahydroxyflavone) is a characteristic flavonol that has six hydroxy (–OH) group based on the chemical structure of the flavone backbone. Herein, we report a concise, efficient, and scalable synthesis of biologically important quercetagetin with antioxidant and antibacterial activities. The synthesis has been achieved in three steps from starting materials 1 and 2 in 27 % overall yield. The chemical structure of synthetic quercetagetin has been confirmed by 1H NMR, 13C NMR, and high-resolution mass spectrometry (HRMS) analyses. Antioxidant activity of synthetic quercetagetin and control compounds quercetin, butylated hydroxyanisole (BHA), and Trolox has been compared using DPPH and ABTS radical scavenging assays. The synthetic quercetagetin exhibits the highest antioxidant activity when compared with control compounds. Furthermore, the synthetic quercetagetin has displayed potent antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains with MIC value of 16 µg/mL when compared with standard antibiotic drugs Ampicillin and Kanamycin (with MIC values of >256 µg/mL). To distinguish bactericidal and bacteriostatic effects of synthetic quercetagetin, time-kill kinetic studies have been performed and the results exhibit that the synthetic quercetagetin possesses bacteriostatic action.

Istanbul nufusunun son yari yuzyilda hizli bir sekilde artmasi, konut ve kentlesmede sorunlara neden olmustur. Sorunun hizli yapilasma yaklasimiyla giderilmeye calisilmasi da ayrica farkli sorunlari beraberinde getirmistir. Bu sorunlarin en onemlilerinden biri kentteki yagmur suyu taskinlaridir. Bu nedenle her siddetli yagmur sonrasi Istanbul’un bircok yerinde taskinlar olusmaktadir. Kent icin maddi ve manevi zarara neden olan bu taskinlar, ekolojik acidan da ciddi bir kirlilik yaratmaktadir. Yagmur suyu taskinlarinda, yuzey suyunun cogalmasi onemli bir faktordur. Asiri yapilasma ile yaratilan gecirimsiz tabakadan dolayi toprak yuzeyi altina sizma imkâni bulamayan yagmur suyu, kacinilmaz olarak yuzeyde akmakta ve artarak kentin en dusuk noktalarinda birikmektedir. Suyun asiri sekilde biriktigi bu tur noktalarda sebekelerin yetersiz kalmasi, taskinlarin meydana gelmesi kacinilmaz olmaktadir. Bu noktada, yapilasmada “Yesil teras cati” denilen sistemlerin yayginlastirilarak kullanilmasi, bu tur taskin problemlerinin azaltilmasina katki saglayacaktir. Bu makalede Istanbul kentinde yagmur suyundan kaynaklanan taskin problemlerine yesil cati sistemlerinin nasil onleyici bir fonksiyon ustlenebilecegi ele alinmaktadir.

Amac : Bu calismada akut lenfoblastik losemi (ALL) on tanili olgularda t(12;21) translokasyonu gercek zamanli kantitatif revers transkriptaz polimeraz zincir reaksiyonu (qRT-PZR) yontemi kullanilarak kantite edildi. Hastalar ve yontemler : Ocak 2009 - Aralik 2013 tarihleri arasinda Ege Universitesi Tip Fakultesi Tibbi Biyoloji Anabilim Dali’na basvuran 175 pediatrik ve 138 eriskin olmak uzere toplam 313 olguya ait kan ve kemik iligi orneklerinde t(12;22) (p13;q22) translokasyonu RNA sonuclari kantitatif olarak degerlendirildi. Olgulara ait 75 kan ve 484 kemik iligi orneklerinden total RNA veya haberci RNA izole edildi. RNA izolasyonlarinin ardindan tamamlayici DNA sentezi gerceklestirildi. t(12;21) (p13;q22) translokasyon calismasi LightCycler t(12;21) Kit’i ile fuzyon transkripte ozgul bicimde tasarlanmis primer ve problarla (Way2Gene) uygun olacak sekilde gerceklestirildi. Son adim olarak, t(12;21) translokasyon sonuclarinin kantitatif olarak degerlendirilmesi gercek zamanli qRT-PZR yontemi kullanilarak LightCycler2 ile gerceklestirildi. Bulgular : Otuz dort pediatrik olgu orneginde (%19) ve 17 eriskin olgunun orneginde (%12) TEL-AML-1 (ETV6-RUNX1) pozitif bulundu. TEL-AML1 (ETV6-RUNX1) kantitasyon degeri ortalamasi pediatrik olgularda 0.90±3.21, eriskin olgularda ise 0.34±1.20 olarak belirlendi. Sonuc : Elde ettigimiz veriler, gercek zamanli qRT-PZR yontemi ile ALL hastalarinda yeni tani doneminde ve tedavi surecinde t(12;21) translokasyonunun kantitatif tayininin hem taninin kesinlestirilmesinde hem de molekuler remisyon saglanmasina yonelik tedaviyi yonlendirmesinde degerli bir yontem oldugunu desteklemektedir.

The role of IL-25 and IL-33 in the aetiology and pathogenesis of nasal polyps has been controversial in the literature. The objective of the study is to detect serum and tissue levels of IL-25 and IL-33 in patients with (CRSwNP) or without (CRSsNP) nasal polyps using enzyme-linked immunosorbent assay (ELISA). Study group consisted of 20 CRSwNP and 20 CRSsNP patients. Control group comprised of 20 volunteers who had been operated with septum deviation without any additional sinonasal pathology, allergy, systemic disease, or medication use. All groups preoperatively underwent paranasal CT examinations and sinonasal pathologies were recorded based on Lund–Mackay radiological staging system. IL-25 and IL-33 levels in serum and tissue samples were analyzed using the ELISA method. Serum IL-25 and IL-33 levels in CRSsNP, CRSwNP, and control groups did not differ statistically significantly (p = 0.345 and p = 0.338). Any statistically significant difference was not detected in mean tissue IL-25 levels among CRSsNP, CRSwNP, and control groups (p = 0.698). Mean tissue IL-33 level in the CRSwNP group was statistically significantly lower when compared with those of CRSsNP and control groups (p

Polyelectrolyte multilayer (PEM) films composed of two natural polysaccharides (hyaluronic acid and chitosan) were deposited through layer-by-layer (LbL) assembly on top of biocompatible mesoporous silica nanoparticles (MSNPs). Polyelectrolyte multilayer coated mesoporous silica nanoparticles (PEM-MSNPs) were characterized by using attenuated total reflection–fourier transform infrared spectroscopy (ATR–FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), nitrogen adsorption-desorption isotherms, UV–vis and fluorescence spectrophotometer. A commercially available and industrially used optical brightener, 4,4′-distyrylbiphenyl sulfonate sodium salt (CBSX) was loaded into nanocontainers (CBSX@PEM-MSNPs) to evaluate their use for the pH-sensitive release. The controlled release of CBSX from nanocontainers in response to pH is monitored by using UV–vis and fluorescence spectrophotometer in water and the almost 100% of encapsulated CBSX is released within 2 h at pH 7. The increase in both whiteness and total color change at pH 7 on a cellulose fabric demonstrates the great potential of nanocontainers as pH-sensitive whitening agents for optical bleaching of cellulose fabrics.

Corn is the most commonly produced crop in the world producing immense agricultural residues, including corn husks. In search for handling corn husks as a fiber source, the quality of fibers extracted from different parts of corn husks by water retting is investigated. The effects of the location of the leaves in the husks and the part of the leaves where the fibers were extracted from on the mechanical, physical, and chemical characteristics of the fibers have been investigated. The coarseness of extracted fibers decreases from outer to the inner leaves in the husk and from the lower to the upper parts of the leaves. Breaking tenacity, breaking force, and elongation at break values of the fibers increase from the upper to the lower parts of the husk leaves. The fibers from the lower parts of the leaves showed greater hemicellulose, pectin, moisture content, and water absorption capacity compared to fibers obtained from the upper part of the corn husk leaves. With superior mechanical properties and lower moisture content and water absorption fibers from the lower parts of corn husk leaves may be considered advantageous for technical use such as in fiberboards. The fibers from the upper portion that are finer and can hold more moisture are more advantageous in terms of comfort aspects. The mechanical properties of the obtained water-retted fibers have been found to be superior to the corn husk fibers of prior studies produced by alkalization. © 2016 Taylor & Francis.