462 results on '"Deutz, P."'
Search Results
152. Enhancement of chemically induced bladder carcinoma by cyclosporin A
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Recker, F., Rübben, H., Homburg, A., Deutz, F. -J., Sieberth, H. -G., and Lutzeyer, W.
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- 1988
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153. Major surgery diminishes systemic arginine availability and suppresses nitric oxide response to feeding in patients with early stage breast cancer.
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Engelen, Mariëlle P.K.J., Klimberg, V. Suzanne, Allasia, Arianna, and Deutz, Nicolaas E.P.
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Summary Background & aims Plasma arginine (ARG) levels are reduced in breast cancer, suggesting diminished systemic ARG availability. ARG and its product nitric oxide (NO) are important in early postoperative recovery due to its roles in immune function and wound healing. It remains unclear whether major surgery further diminishes systemic ARG availability due to enhanced ARG catabolism and/or insufficient endogenous ARG synthesis negatively affecting NO synthesis in patients with early stage breast cancer. Methods In 9 women with early stage breast malignancy and 9 healthy women with genetic predisposition to breast cancer, whole body ARG and citrulline (CIT) rates of appearances were measured to determine their production rates prior to and within 24 h after major breast surgery by stable isotope methodology in the postabsorptive and postprandial state. The conversions of CIT > ARG, ARG > CIT, and ARG > Urea (markers of de novo ARG and NO synthesis, arginase activity, respectively), and ARG clearance (reflecting ARG disposal capacity) were calculated. Results Prior to surgery, plasma ARG, CIT and glutamine concentrations were lower in cancer (P < 0.05) but no differences were found in the rate of appearances of ARG, CIT and their conversions. Surgery increased ARG clearance and reduced CIT rate of appearance, conversion of CIT > ARG (P < 0.001), and plasma ARG, CIT, ornithine concentrations (P < 0.001). Furthermore, postprandial increase in ARG > CIT conversion (P < 0.05), plasma ARG (P < 0.001) and CIT (P = 0.06) concentrations were lower after surgery. The cancer group had lower values for postprandial increase in ARG > CIT conversion, plasma CIT (P < 0.05) and glutamine concentrations (P = 0.08). Conclusions Major surgery in early stage breast cancer further reduces systemic ARG availability in the early phase of recovery due to a combined process of increased ARG catabolism and impaired endogenous ARG synthesis. The suppressed postprandial NO increase in early stage cancer suggests that specific nutritional approaches are advised to increase ARG availability after major surgery although the effects on postoperative recovery remain unclear. This trial was registered at clinicaltrials.gov as NCT00497380. [ABSTRACT FROM AUTHOR]
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- 2018
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154. Update on maximal anabolic response to dietary protein.
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Kim, Il-Young, Deutz, Nicolaas E.P., and Wolfe, Robert R.
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Summary The anabolic response to dietary protein can be defined as the difference between protein synthesis and breakdown, or the net protein balance, in response to ingestion of protein alone or a mixed meal containing protein. Others have concluded that a maximal anabolic response can be achieved with ingestion of 20–35 g of a high quality protein, leading to the formulation of a popular concept that the maximal anabolic response can be achieved by distributing the total protein intake evenly throughout the day, rather than eating a majority of dietary protein with dinner. However, this concept was based entirely on the measurement of muscle protein synthesis and thus ignored the potential contributions of suppression of protein breakdown to the anabolic response, as well as the possibility that tissues and organs other than muscle may also play a role in the anabolic response. In this review we discuss the factors comprising the total anabolic response, discuss relevant methodological issues, derive a theoretical maximal anabolic response based on current literature values, and interpret recent papers addressing the issue of maximal anabolic response as well as meal distribution of dietary protein. We conclude that it is not likely that there is a practical limit to the maximal anabolic response to a single meal, and the most efficient way in which to maximize the total anabolic response over a 24-h period is to increase dietary protein at breakfast and lunch without reducing protein intake with dinner. [ABSTRACT FROM AUTHOR]
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- 2018
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155. Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group.
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Calder, Philip C., Adolph, Michael, Deutz, Nicolaas E., Grau, Teodoro, Innes, Jacqueline K., Klek, Stanislaw, Lev, Shaul, Mayer, Konstantin, Michael-Titus, Adina T., Pradelli, Lorenzo, Puder, Mark, Vlaardingerbroek, Hester, and Singer, Pierre
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Summary This article summarizes the presentations given at an ESPEN Workshop on “Lipids in the ICU” held in Tel Aviv, Israel in November 2014 and subsequent discussions and updates. Lipids are an important component of enteral and parenteral nutrition support and provide essential fatty acids, a concentrated source of calories and building blocks for cell membranes. Whilst linoleic acid-rich vegetable oil-based enteral and parenteral nutrition is still widely used, newer lipid components such as medium-chain triglycerides and olive oil are safe and well tolerated. Fish oil (FO)-enriched enteral and parenteral nutrition appears to be well tolerated and confers additional clinical benefits, particularly in surgical patients, due to its anti-inflammatory and immune-modulating effects. Whilst the evidence base is not conclusive, there appears to be a potential for FO-enriched nutrition, particularly administered peri-operatively, to reduce the rate of complications and intensive care unit (ICU) and hospital stay in surgical ICU patients. The evidence for FO-enriched nutrition in non-surgical ICU patients is less clear regarding its clinical benefits and additional, well-designed large-scale clinical trials need to be conducted in this area. The ESPEN Expert Group supports the use of olive oil and FO in nutrition support in surgical and non-surgical ICU patients but considers that further research is required to provide a more robust evidence base. [ABSTRACT FROM AUTHOR]
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- 2018
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156. Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosaModel of Sepsis Using Nontargeted Metabolomics Analysis
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Ilaiwy, Amro, ten Have, Gabriella A.M., Bain, James R., Muehlbauer, Michael J., O'Neal, Sara K., Berthiaume, Jessica M., Parry, Traci L., Deutz, Nicolaas E., and Willis, Monte S.
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Sepsis is a multiorgan disease affecting the ileum and jejunum (small intestine), liver, skeletal muscle, and lung clinically. The specific metabolic changes in the ileum, jejunum, liver, skeletal muscle, and lung have not previously been investigated. Live Pseudomonas aeruginosa, isolated from a patient, was given via i.v. catheter to pigs to induce severe sepsis. Eighteen hours later, ileum, jejunum, medial gastrocnemius skeletal muscle, liver, and lung were analyzed by nontargeted metabolomics analysis using gas chromatography/mass spectrometry. The ileum and the liver demonstrated significant changes in metabolites involved in linoleic acid metabolism: the ileum and lung had significant changes in the metabolism of valine/leucine/isoleucine; the jejunum, skeletal muscle, and liver had significant changes in arginine/proline metabolism; and the skeletal muscle and lung had significant changes in aminoacyl-tRNA biosynthesis, as analyzed by pathway analysis. Pathway analysis also identified changes in metabolic pathways unique for different tissues, including changes in the citric acid cycle (jejunum), β-alanine metabolism (skeletal muscle), and purine metabolism (liver). These findings demonstrate both overlapping metabolic pathways affected in different tissues and those that are unique to others and provide insight into the metabolic changes in sepsis leading to organ dysfunction. This may allow therapeutic interventions that focus on multiple tissues or single tissues once the relationship of the altered metabolites/metabolism to the underlying pathogenesis of sepsis is determined.
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- 2019
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157. Lifetime test on EUV photomask with EBL2
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Ando, Akihiko, Wu, Chien-Ching, Bender, Markus, Jonckheere, Rik, Scholze, Frank, Bekman, Herman, van Putten, Michel, de Zanger, Rory, Ebeling, Rob, Westerhout, Jeroen, Nicolai, Kyri, van Veldhoven, Jacqueline, de Rooij-Lohmann, Véronique, Kievit, Olaf, and Deutz, Alex
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- 2019
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158. Apparate zur Gasanalyse
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Matzerath, J., Traberg, Niels Jörgen, Wilhelmi, Arthur, Wempe, G., Deutz, Gasmotorenfabrik, Harger, F. D., Greiner, Friedrichs, Hammermann, Goegg, E. J., Deming, H. C., Mauguin, E., Johannsen, Otto, Gilbert, H. N., Burrell, G. A., Weaver, E. R., Edwards, J. D., Forrières, R. Henr, Elliot, A. H., Oberfell, G. H., Frerichs, G., Mannheim, E., Richardson, F. W., Jaffée, A., Kaesbohrer, H., Richmond, H. Droop, Hembrough, E., Gray, Harold Heath, Schuhmacher, G., Neuberg, Jens O., Jacquerod, A., Tourpaïan, Contzen, Baxter, G. T., Storkweather, H. W., and Société Roubaisienne d'Eclairage
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- 1919
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159. Acute microbial protease supplementation increases net postprandial plasma amino acid concentrations after pea protein ingestion in healthy adults: a randomized, double-blind, placebo-controlled trial
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Paulussen, Kevin J.M., Askow, Andrew T., Deutz, Max T., McKenna, Colleen F., Garvey, Sean M., Guice, Justin L., Kesler, Richard M., Barnes, Takeshi M., Tinker, Kelly M., Paluska, Scott A., Ulanov, Alexander V., Bauer, Laura L., Dilger, Ryan N., and Burd, Nicholas A.
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Digestibility is a primary factor in determining the quality of dietary protein. Microbial protease supplementation may be a strategy for improving protein digestion and subsequent postprandial plasma amino acid availability.
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- 2024
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160. Archaeological tourism: A creative approach.
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Ross, David, Saxena, Gunjan, Correia, Fernando, and Deutz, Pauline
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This theoretical paper conceptualises the role of tourism providers in facilitating creative tourism experiences by focusing on their ingenious enterprise, which we argue can help capture the tourism potential of intangible archaeological heritage. Intangible archaeological heritage can be understood as knowledge emanating from actors’ own interpretation of archaeological sites that have either become physically inaccessible or been destroyed since initial exploration. Archaeological heritage is often equated with tangibility, which results in an omission of experiences that intangible archaeological heritage can offer. By proposing a rethinking of the archaeological tourism framework, we argue that the touristic value of both tangible and intangible archaeological heritage is better realised and can be further utilised to study the easily overlooked aspect of providers’ ingenuity. [ABSTRACT FROM AUTHOR]
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- 2017
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161. Resource recovery and remediation of highly alkaline residues: A political-industrial ecology approach to building a circular economy.
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Deutz, Pauline, Baxter, Helen, Gibbs, David, Mayes, William M., and Gomes, Helena I.
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INDUSTRIAL waste site remediation ,ALKALIES ,INDUSTRIAL ecology ,POLITICAL ecology ,TECHNOLOGICAL innovations - Abstract
Highly alkaline industrial residues (e.g., steel slag, bauxite processing residue (red mud) and ash from coal combustion) have been identified as stocks of potentially valuable metals. Technological change has created demand for metals, such as vanadium and certain rare earth elements, in electronics associated with renewable energy generation and storage. Current raw material and circular economy policy initiatives in the EU and industrial ecology research all promote resource recovery from residues, with research so far primarily from an environmental science perspective. This paper begins to address the deficit of research into the governance of resource recovery from a novel situation where re-use involves extraction of a component from a bulk residue that itself represents a risk to the environment. Taking a political industrial ecology approach, we briefly present emerging techniques for recovery and consider their regulatory implications in the light of potential environmental impacts. The paper draws on EU and UK regulatory framework for these residues along with semi-structured interviews with industry and regulatory bodies. A complex picture emerges of entwined ownerships and responsibilities for residues, with past practice and policy having a lasting impact on current possibilities for resource recovery. [ABSTRACT FROM AUTHOR]
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- 2017
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162. ESPEN expert group recommendations for action against cancer-related malnutrition.
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Arends, J., Baracos, V., Bertz, H., Bozzetti, F., Calder, P.C., Deutz, N.E.P., Erickson, N., Laviano, A., Lisanti, M.P., Lobo, D.N., McMillan, D.C., Muscaritoli, M., Ockenga, J., Pirlich, M., Strasser, F., de van der Schueren, M., Van Gossum, A., Vaupel, P., and Weimann, A.
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Summary Patients with cancer are at particularly high risk for malnutrition because both the disease and its treatments threaten their nutritional status. Yet cancer-related nutritional risk is sometimes overlooked or under-treated by clinicians, patients, and their families. The European Society for Clinical Nutrition and Metabolism (ESPEN) recently published evidence-based guidelines for nutritional care in patients with cancer. In further support of these guidelines, an ESPEN oncology expert group met for a Cancer and Nutrition Workshop in Berlin on October 24 and 25, 2016. The group examined the causes and consequences of cancer-related malnutrition, reviewed treatment approaches currently available, and built the rationale and impetus for clinicians involved with care of patients with cancer to take actions that facilitate nutrition support in practice. The content of this position paper is based on presentations and discussions at the Berlin meeting. The expert group emphasized 3 key steps to update nutritional care for people with cancer: (1) screen all patients with cancer for nutritional risk early in the course of their care, regardless of body mass index and weight history; (2) expand nutrition-related assessment practices to include measures of anorexia, body composition, inflammatory biomarkers, resting energy expenditure, and physical function; (3) use multimodal nutritional interventions with individualized plans, including care focused on increasing nutritional intake, lessening inflammation and hypermetabolic stress, and increasing physical activity. [ABSTRACT FROM AUTHOR]
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- 2017
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163. Towards a multidisciplinary approach to understand and manage obesity and related diseases.
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Bischoff, Stephan C., Boirie, Yves, Cederholm, Tommy, Chourdakis, Michael, Cuerda, Cristina, Delzenne, Nathalie M., Deutz, Nicolaas E., Fouque, Denis, Genton, Laurence, Gil, Carmen, Koletzko, Berthold, Leon-Sanz, Miguel, Shamir, Raanan, Singer, Joelle, Singer, Pierre, Stroebele-Benschop, Nanette, Thorell, Anders, Weimann, Arved, and Barazzoni, Rocco
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Summary Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best metabolic and nutritional outcome, as well as to induce potential disease-specific benefits from selected nutritional regimens. Obesity is usually accompanied by an increased muscle mass. This might explain why obesity, under particular circumstances such as cancer or high age, might have protective effects, a phenomenon named the ‘obesity paradox’. However, loss of muscle mass or function can also occur, which is associated with poor prognosis and termed ‘sarcopenic obesity’. Therefore, treatment recommendations may need to be individualized and adapted to co-morbidities. Since obesity is a chronic systemic disease it requires a multidisciplinary approach, both at the level of prevention and therapy including weight loss and maintenance. In the present personal review and position paper, authors from different disciplines including endocrinology, gastroenterology, nephrology, pediatrics, surgery, geriatrics, intensive care medicine, psychology and psychiatry, sports medicine and rheumatology, both at the basic science and clinical level, present their view on the topic and underline the necessity to provide a multidisciplinary approach, to address this epidemic. [ABSTRACT FROM AUTHOR]
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- 2017
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164. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children – A stable isotope tracer study.
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de Betue, Carlijn T.I., Garcia Casal, Xiomara C., van Waardenburg, Dick A., Schexnayder, Stephen M., Joosten, Koen F.M., Deutz, Nicolaas E.P., and Engelen, Marielle P.K.J.
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Summary Background & aims The reference method to study protein and arginine metabolism in critically ill children is measuring plasma amino acid appearances with stable isotopes during a short (4–8 h) time period and extrapolate results to 24-h. However, 24-h measurements may be variable due to critical illness related factors and a circadian rhythm could be present. Since only short duration stable isotope studies in critically ill children have been conducted before, the aim of this study was to investigate 24-h appearance of specific amino acids representing protein and arginine metabolism, with stable isotope techniques in continuously fed critically ill children. Methods In eight critically ill children, admitted to the pediatric (n = 4) or cardiovascular (n = 4) intensive care unit, aged 0–10 years, receiving continuous (par)enteral nutrition with protein intake 1.0–3.7 g/kg/day, a 24-h stable isotope tracer protocol was carried out. L-[ring- 2 H 5 ]-phenylalanine, L-[3,3- 2 H 2 ]-tyrosine, L-[5,5,5- 2 H 3 ]-leucine, L-[guanido- 15 N 2 ]-arginine and L-[5- 13 C-3,3,4,4- 2 H 4 ]-citrulline were infused intravenously and L-[ 15 N]-phenylalanine and L-[1- 13 C]leucine enterally. Arterial blood was sampled every hour. Results Coefficients of variation, representing intra-individual variability, of the amino acid appearances of phenylalanine, tyrosine, leucine, arginine and citrulline were high, on average 14–19% for intravenous tracers and 23–26% for enteral tracers. No evident circadian rhythm was present. The pattern and overall 24-h level of whole body protein balance differed per individual. Conclusions In continuously fed stable critically ill children, the amino acid appearances of phenylalanine, tyrosine, leucine, arginine and citrulline show high variability. This should be kept in mind when performing stable isotope studies in this population. There was no apparent circadian rhythm. Clinical trial register NCT01511354 on clinicaltrials.gov . [ABSTRACT FROM AUTHOR]
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- 2017
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165. Carbohydrates and insulin resistance in clinical nutrition: Recommendations from the ESPEN expert group.
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Barazzoni, R., Deutz, N.E.P., Biolo, G., Bischoff, S., Boirie, Y., Cederholm, T., Cuerda, C., Delzenne, N., Leon Sanz, M., Ljungqvist, O., Muscaritoli, M., Pichard, C., Preiser, J.C., Sbraccia, P., Singer, P., Tappy, L., Thorens, B., Van Gossum, A., Vettor, R., and Calder, P.C.
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Summary Growing evidence underscores the important role of glycemic control in health and recovery from illness. Carbohydrate ingestion in the diet or administration in nutritional support is mandatory, but carbohydrate intake can adversely affect major body organs and tissues if resulting plasma glucose becomes too high, too low, or highly variable. Plasma glucose control is especially important for patients with conditions such as diabetes or metabolic stress resulting from critical illness or surgery. These patients are particularly in need of glycemic management to help lessen glycemic variability and its negative health consequences when nutritional support is administered. Here we report on recent findings and emerging trends in the field based on an ESPEN workshop held in Venice, Italy, 8–9 November 2015. Evidence was discussed on pathophysiology, clinical impact, and nutritional recommendations for carbohydrate utilization and management in nutritional support. The main conclusions were: a) excess glucose and fructose availability may exacerbate metabolic complications in skeletal muscle, adipose tissue, and liver and can result in negative clinical impact; b) low-glycemic index and high-fiber diets, including specialty products for nutritional support, may provide metabolic and clinical benefits in individuals with obesity, insulin resistance, and diabetes; c) in acute conditions such as surgery and critical illness, insulin resistance and elevated circulating glucose levels have a negative impact on patient outcomes and should be prevented through nutritional and/or pharmacological intervention. In such acute settings, efforts should be implemented towards defining optimal plasma glucose targets, avoiding excessive plasma glucose variability, and optimizing glucose control relative to nutritional support. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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166. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults.
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Jonker, Renate, Deutz, Nicolaas EP, Erbland, Marcia L, Anderson, Paula J, and Engelen, Mariëlle PKJ
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PROTEIN metabolism ,OBSTRUCTIVE lung diseases patients ,ESSENTIAL amino acids ,DIETARY supplements ,MUSCULAR atrophy - Abstract
Background The development of effective nutritional strategies in support of muscle growth for patients with chronic obstructive pulmonary disease (COPD) remains challenging. Dietary essential amino acids (EAAs) are the main driver of postprandial net protein anabolism. In agreement, EAA supplements in healthy older adults are more effective than supplements with the composition of complete proteins. In patients with COPD it is still unknown whether complete protein supplements can be substituted with only EAAs, and whether they are as effective as in healthy older adults. Methods According to a double-blind randomized crossover design, we examined in 23 patients with moderate to very severe COPD (age: 65 ± 2 years, FEV 1 : 40 ± 2% of predicted) and 19 healthy age-matched subjects (age: 64 ± 2 years), whether a free EAA mixture with a high proportion (40%) of leucine (EAA mixture) stimulated whole body net protein gain more than a similar mixture of balanced free EAAs and non-EAAs as present in whey protein (TAA mixture). Whole body net protein gain and splanchnic extraction of phenylalanine (PHE) were assessed by continuous IV infusion of L-[ring- 2 H 5 ]-PHE and L-[ring- 2 H 2 ]-tyrosine, and enteral intake of L-[ 15 N]-PHE (added to the mixtures). Results Besides an excellent positive linear relationship between PHE intake and net protein gain in both groups (r = 0.84–0.91, P < 0.001), net protein gain was 42% higher in healthy controls and 49% higher in COPD patients after intake of the EAA mixture compared to the TAA mixture ( P < 0.0001). These findings could not be attributed to the high LEU content, as in both groups net protein gain per gram EAA intake was lower for the EAA mixture ( P < 0.0001). Net protein gain was higher in COPD patients for both mixtures due to a 40% lower splanchnic extraction ( P < 0.0001), but was similarly related to dietary PHE (i.e. EAA) plasma appearance. Conclusions In COPD patients, similarly to healthy older adults, free EAA supplements stimulate whole body protein anabolism more than free amino acid supplements with the composition of complete proteins. Therefore, free EAA supplements may aid in the prevention and treatment of muscle wasting in this patient population. [ABSTRACT FROM AUTHOR]
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- 2017
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167. Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis.
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Deutz, Nicolaas E.P., Singer, Pierre, Wierzchowska-McNew, Raven A., Viana, Marina V., Ben-David, Itai A., Pantet, Olivier, Thaden, John J., Ten Have, Gabriella A.M., Engelen, Mariëlle P.K.J., and Berger, Mette M.
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AMINO acid analysis ,GLUTAMINE ,CRITICALLY ill ,AMINO acids ,AMINO acid metabolism ,FEMALES - Abstract
The trajectory from healthy to critical illness is influenced by numerous factors, including metabolism, which differs substantially between males and females. Whole body protein breakdown is substantially increased in critically ill patients, but it remains unclear whether there are sex differences that could explain the different health outcomes. Hence, we performed a secondary analysis of a study, where we used a novel pulse isotope method in critically ill and matched healthy males and females. In 51 critically ill ICU patients (26 males, 15 females) and 49 healthy controls (36 males and 27 females), we assessed their general and disease characteristics and collected arterial(ized) blood in the postabsorptive state after pulse administration of 8 ml of a solution containing 18 stable AA tracers. In contrast to the original study, we now fitted the decay curves and calculated non-compartmental whole body amino acid production (WBP) and compartmental measurements of metabolism, including intracellular amino acid production. We measured amino acid enrichments and concentrations by LC-MS/MS and derived statistics using AN(C)OVA. Critically ill males and females showed an increase in the WBP of many amino acids, including those related to protein breakdown, but females showed greater elevations, or in the event of a reduction, attenuated reductions. Protein breakdown-independent WBP differences remained between males and females, notably increased glutamine and glutamate WBP. Only severely ill females showed a lower increase in WBP of many amino acids in comparison to moderately ill females, suggesting a suppressed metabolism. Compartmental analysis supported the observations. The present study shows that females have a different response to critical illness in the production of several amino acids and changes in protein breakdown, observations made possible using our innovative stable tracer pulse approach. Data are from the baseline measurements of study NCT02770092 (URL: https://clinicaltrials.gov/ct2/show/NCT02770092) and NCT03628365 (URL: https://clinicaltrials.gov/ct2/show/NCT03628365). • Critically ill females have the highest increase and attenuated reduction of amino acid pathways. • Large differences between males and females exist specifically for glutamine and glutamate whole body productions. • Severely ill females showed a suppressed metabolism. Compartmental analysis supported the observations. [ABSTRACT FROM AUTHOR]
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- 2023
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168. Investigating household recycling behaviour through the interactions between personal and situational factors
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A-Jalil, E. E., primary, Grant, D. B., additional, Nicholson, J. D., additional, and Deutz, P., additional
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- 2014
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169. Flexible Lead‐Free Piezoelectric Composite Materials for Energy Harvesting Applications
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Stuber, Vincent L., Deutz, Daniella B., Bennett, James, Cannel, David, de Leeuw, Dago M., van der Zwaag, Sybrand, and Groen, Pim
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Vibrational piezoelectric energy harvesters are being investigated to replace batteries in embedded sensor systems. The energy density that can be harvested depends on the figure of merit, d33g33, where d33and g33are the piezoelectric charge and voltage coefficient. Commonly used piezoelectric materials are based on inorganic ceramics, such as lead zirconium titanate (PZT), as they exhibit high piezoelectric coefficients. However, ceramics are brittle, leading to mechanical failure under large cyclic strains and, furthermore, PZT is classified as a Substance of Very High Concern (SVHC). To circumvent these drawbacks, we fabricated quasi 1–3 potassium sodium lithium niobate (KNLN) ceramic fibers in a flexible polydimethylsiloxane (PDMS) matrix. The fibers were aligned by dielectrophoresis. We demonstrate for the structured composites values of d33g33approaching 18 pm3J−1, comparable to that of state‐of‐the‐art ceramic PZT. This relatively high value is due to the reduced inter‐particle distance in the direction of the electric field. As a confirmation, the stored electrical energy for both material systems was measured under identical mechanical loading conditions. The similar values for KNLN/PDMS and PZT demonstrate that environmentally friendly, lead‐free, mechanically compliant materials can replace state‐of‐the‐art environmentally‐less‐desirable ceramic materials in piezoelectric vibrational energy harvesters. Environmentally friendly, lead‐free, mechanically compliant materials that can replace state‐of‐the‐art ceramic materials in piezoelectric vibrational energy harvesters are presented. To minimize the distance between the KNLN fibers, they were aligned through dielectrophoresis. The extracted figure of merit for vibrational energy harvesting, d33g33, reaches 18 pm3J−1, at low filler volume fraction of only 6 %. The value is similar to that of state‐of‐the‐art ceramic PZT.
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- 2019
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170. Is β-hydroxy β-methylbutyrate an effective anabolic agent to improve outcome in older diseased populations?
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Engelen, Mariëlle P.K.J. and Deutz, Nicolaas E.P.
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- 2018
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171. Integrating sustainable waste management into product design: sustainability as a functional requirement
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Deutz, P, Neighbour, G, McGuire, M, Deutz, P, Neighbour, G, and McGuire, M
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Municipal waste management is, by definition, spatially organized. In the United Kingdom the national government designates waste collection and disposal responsibilities to the various scales of local government. However, whilst the highest aim of waste management is prevention, achieving this is beyond the scope of local authorities, which deal with the waste stream presented to them as an independent variable. Alternatively, product design offers a potential point of policy intervention, by which the waste stream becomes a dependent variable. This paper innovatively argues that, for eco-design to be effective, sustainable waste management must be established as a functional requirement in the design process.
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- 2010
172. Short-chain fatty acid production in accessible and inaccessible body pools as assessed by novel stable tracer pulse approach is reduced by aging independent of presence of COPD.
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Kirschner, Sarah K., Ghane, Parisa, Park, Jaekwan K., Simbo, Sunday Y., Ivanov, Ivan, Braga-Neto, Ulisses M., Ten Have, Gabriëlla A.M., Thaden, John J., Engelen, Mariëlle P.K.J., and Deutz, Nicolaas E.P.
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BUTYRATES ,RUMEN fermentation ,SHORT-chain fatty acids ,EXTRACELLULAR fluid ,CHRONIC obstructive pulmonary disease ,YOUNG adults ,OLDER people ,GUT microbiome - Abstract
Production rates of the short-chain fatty acids (SCFA) acetate, propionate, and butyrate, which are beneficial metabolites of the intestinal microbiota, are difficult to measure in humans due to inaccessibility of the intestine to perform measurements, and the high first-pass metabolism of SCFAs in colonocytes and liver. We developed a stable tracer pulse approach to estimate SCFA whole-body production (WBP) in the accessible pool representing the systemic circulation and interstitial fluid. Compartmental modeling of plasma enrichment data allowed us to additionally calculate SCFA kinetics and pool sizes in the inaccessible pool likely representing the intestine with microbiota. We also studied the effects of aging and the presence of Chronic Obstructive Pulmonary Disease (COPD) on SCFA kinetics. In this observational study, we designed a two-compartmental model to determine SCFA kinetics in 31 young (20–29 y) and 71 older (55–87 y) adults, as well as in 33 clinically stable patients with moderate to very severe COPD (mean (SD) FEV 1 , 46.5 (16.2)% of predicted). Participants received in the fasted state a pulse containing stable tracers of acetate, propionate, and butyrate intravenously and blood was sampled four times over a 30 min period. We measured tracer-tracee ratios by GC–MS and used parameters obtained from two-exponential curve fitting to calculate non-compartmental SCFA WBP and perform compartmental analysis. Statistics were done by ANCOVA. Acetate, propionate, and butyrate WBP and fluxes between the accessible and inaccessible pools were lower in older than young adults (all q < 0.0001). Moreover, older participants had lower acetate (q < 0.0001) and propionate (q = 0.019) production rates in the inaccessible pool as well as smaller sizes of the accessible and inaccessible acetate pools (both q < 0.0001) than young participants. WBP, compartmental SCFA kinetics, and pool sizes did not differ between COPD patients and older adults (all q > 0.05). Overall and independent of the group studied, calculated production rates in the inaccessible pool were on average 7 (acetate), 11 (propionate), and 16 (butyrate) times higher than non-compartmental WBP, and sizes of inaccessible pools were 24 (acetate), 31 (propionate), and 55 (butyrate) times higher than sizes of accessible pools (all p < 0.0001). Non-compartmental production measurements of SCFAs in the accessible pool (i.e. systemic circulation) substantially underestimate the SCFA production in the inaccessible pool, which likely represents the intestine with microbiota, as assessed by compartmental analysis. [Display omitted] • Previous methods to measure (intestinal) SCFA production might be inaccurate. • We assessed SCFA production with stable tracer pulse approach and compartmental modeling. • SCFA production and fluxes were reduced in aging but not affected by presence of COPD. • Non-compartmental SCFA production measurements underestimate production in inaccessible (intestinal) pool. [ABSTRACT FROM AUTHOR]
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- 2023
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173. Maximizing Consensus in Portfolio Selection in Multicriteria Group Decision Making.
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Emmerich, Michael, Deutz, André, Li, Longmei, Maulana, Asep, and Yevseyeva, Iryna
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PORTFOLIO assessment (Education) ,GROUP decision making ,CUMULATIVE distribution function ,COMPUTING platforms ,CONSENSUS (Social sciences) ,MULTIPLE criteria decision making - Abstract
This paper deals with a scenario of decision making where a moderator selects a (sub)set (aka portfolio) of decision alternatives from a larger set. The larger the number of decision makers who agree on a solution in the portfolio the more successful the moderator is. We assume that decision makers decide independently from each other but indicate their preferences with respect to different objectives in terms of desirability functions, which can be interpreted as cumulative (probability) density functions. A procedure to select a solution with maximal expected number of decision makers that accept it is provided. Moreover, this is generalized to sets of solutions. An algorithm for computing and maximizing the expected number of decision makers that can agree on at least one solution in a subset of decision alternatives is developed. Computational aspects, as well as practical examples for using this for item selection from a database will be discussed. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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174. Combining nutrition and exercise to optimize survival and recovery from critical illness: Conceptual and methodological issues.
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Heyland, Daren K., Stapleton, Renee D., Mourtzakis, Marina, Hough, Catherine L., Morris, Peter, Deutz, Nicolaas E., Colantuoni, Elizabeth, Day, Andrew, Prado, Carla M., and Needham, Dale M.
- Abstract
Summary Survivors of critical illness commonly experience neuromuscular abnormalities, including muscle weakness known as ICU-acquired weakness (ICU-AW). ICU-AW is associated with delayed weaning from mechanical ventilation, extended ICU and hospital stays, more healthcare-related hospital costs, a higher risk of death, and impaired physical functioning and quality of life in the months after ICU admission. These observations speak to the importance of developing new strategies to aid in the physical recovery of acute respiratory failure patients. We posit that to maintain optimal muscle mass, strength and physical function, the combination of nutrition and exercise may have the greatest impact on physical recovery of survivors of critical illness. Randomized trials testing this and related hypotheses are needed. We discussed key methodological issues and proposed a common evaluation framework to stimulate work in this area and standardize our approach to outcome assessments across future studies. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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175. Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis.
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Oshima, Taku, Deutz, Nicolaas E., Doig, Gordon, Wischmeyer, Paul E., and Pichard, Claude
- Abstract
Summary Background & aims We hypothesize that an optimal and simultaneous provision of energy and protein is favorable to clinical outcome of the critically ill patients. Methods We conducted a review of the literature, obtained via electronic databases and focused on the metabolic alterations during critical illness, the estimation of energy and protein requirements, as well as the impact of their administration. Results Critically ill patients undergo severe metabolic stress during which time a great amount of energy and protein is utilized in a variety of reactions essential for survival. Energy provision for critically ill patients has drawn attention given its association with morbidity, survival and long-term recovery, but protein provision is not sufficiently taken into account as a critical component of nutrition support that influences clinical outcome. Measurement of energy expenditure is done by indirect calorimetry, but protein status cannot be measured with a bedside technology at present. Conclusions Recent studies suggest the importance of optimal and combined provision of energy and protein to optimize clinical outcome. Clinical randomized controlled studies measuring energy and protein targets should confirm this hypothesis and therefore establish energy and protein as a power couple. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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176. Readmission and mortality in malnourished, older, hospitalized adults treated with a specialized oral nutritional supplement: A randomized clinical trial.
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Deutz, Nicolaas E., Matheson, Eric M., Matarese, Laura E., Luo, Menghua, Baggs, Geraldine E., Nelson, Jeffrey L., Hegazi, Refaat A., Tappenden, Kelly A., and Ziegler, Thomas R.
- Abstract
Summary Background Hospitalized, malnourished older adults have a high risk of readmission and mortality. Objective Evaluation of a high-protein oral nutritional supplement (HP-HMB) containing beta-hydroxy-beta-methylbutyrate on postdischarge outcomes of nonelective readmission and mortality in malnourished, hospitalized older adults. Design Multicenter, randomized, placebo-controlled, double-blind trial. Setting Inpatient and posthospital discharge. Patients Older (≥65 years), malnourished (Subjective Global Assessment [SGA] class B or C) adults hospitalized for congestive heart failure, acute myocardial infarction, pneumonia, or chronic obstructive pulmonary disease. Interventions Standard-of-care plus HP-HMB ( n = 328) or a placebo supplement ( n = 324), 2 servings/day. Measurements Primary composite endpoint was 90-day postdischarge incidence of death or nonelective readmission. Other endpoints included 30- and 60-day postdischarge incidence of death or readmission, length of stay (LOS), SGA class, body weight, and activities of daily living (ADL). Results The primary composite endpoint was similar between HP-HMB (26.8%) and placebo (31.1%). No between-group differences were observed for 90-day readmission rate, but 90-day mortality was significantly lower with HP-HMB relative to placebo (4.8% vs. 9.7%; relative risk 0.49, 95% confidence interval [CI], 0.27 to 0.90; p = 0.018). The number-needed-to-treat to prevent 1 death was 20.3 (95% CI: 10.9, 121.4). Compared with placebo, HP-HMB resulted in improved odds of better nutritional status (SGA class, OR, 2.04, 95% CI: 1.28, 3.25, p = 0.009) at day 90, and an increase in body weight at day 30 ( p = 0.035). LOS and ADL were similar between treatments. Limitations Limited generalizability; patients represent a selected hospitalized population. Conclusions Although no effects were observed for the primary composite endpoint, compared with placebo HP-HMB decreased mortality and improved indices of nutritional status during the 90-day observation period. Clinical trial registration www.ClinicalTrials.gov NCT01626742 . [ABSTRACT FROM AUTHOR]
- Published
- 2016
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177. Presenilin-1 polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type
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Bornebroek, M., Haan, J., Backhovens, H., Deutz, P., van Buchem, M.A., Van den Broeck, Marleen, Bakker, E., Roos, R.A.C., and Van Broeckhoven, Christine
- Published
- 1997
178. Analysis and experimental validation of the figure of merit for piezoelectric energy harvestersElectronic supplementary information (ESI) available. See DOI: 10.1039/c8mh00097b
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Deutz, Daniella B., Pascoe, John-Alan, Schelen, Ben, van der Zwaag, Sybrand, de Leeuw, Dago M., and Groen, Pim
- Abstract
Piezoelectric energy harvesters are at the front of scientific research as enablers of renewable, sustainable energy for autonomous wireless sensor networks. Crucial for this disruptive technology is the achievable output power. Here we show, analytically, that the maximum output energy per unit volume, under a single sinusoidal excitation, is equal to 1/(4 − 2k2) × 1/2dgX2, where k2is the electromechanical coupling coefficient, dand gare the piezoelectric charge and voltage coefficient, respectively, and Xis the applied stress. The expression derived is validated by the experimentally measured output energy for a variety of piezoelectric materials over an unprecedented range of more than five orders of magnitude. As the prefactor 1/(4 − 2k2) varies only between 1/2 and 1/4 the figure of merit for piezoelectric materials for energy harvesters is not k2, as commonly accepted for vibrational harvesters, but dg. The figure of merit does not depend on the compliance, or Young's modulus. Hence we argue that commonly used brittle inorganic piezoelectric ceramics can be replaced by soft, mechanically flexible polymers and composite films, comprising inorganic piezoelectric materials embedded in a polymer matrix.
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- 2018
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179. First light and results on EBL2
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Takehisa, Kiwamu, Koster, Norbert, te Sligte, Edwin, Deutz, Alex, Molkenboer, Freek, Muilwijk, Pim, van der Walle, Peter, Mulckhuyse, Wouter, Nijland, Bjorn, Kerkhof, Peter, and van Putten, Michel
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- 2017
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180. First light at EBL2
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Panning, Eric M., Goldberg, Kenneth A., Koster, Norbert, te Sligte, Edwin, Molkenboer, Freek, Deutz, Alex, van der Walle, Peter, Muilwijk, Pim, Mulckhuyse, Wouter, Oostdijck, Bastiaan, Hollemans, Christiaan, Nijland, Björn, Kerkhof, Peter, van Putten, Michel, and Westerhout, Jeroen
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- 2017
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181. Die chronisch-rezidivierende multifokale Osteomyelitis und die tumoröse Kalzinose - assoziierte Erkrankungen?
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Maus, U., primary, Ihme, N., additional, Schroeder, S., additional, Andereya, S., additional, Ohnsorge, J., additional, Hermanns, B., additional, Deutz, P., additional, and Niedhart, C., additional
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- 2007
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182. A Bayesian Approach to Portfolio Selection in Multicriteria Group Decision Making.
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Emmerich, Michael T.M., Deutz, André H., and Yevseyeva, Iryna
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BAYESIAN analysis ,INVESTMENTS ,MULTIPLE criteria decision making ,ECONOMIC demand ,DATABASES - Abstract
In the a-posteriori approach to multicriteria decision making the idea is to first find a set of interesting (usually non-dominated) decision alternatives and then let the decision maker select among these. Often an additional demand is to limit the size of alternatives to a small number of solutions. In this case, it is important to state preferences on sets. In previous work it has been shown that independent normalization of objective functions (using for instance desirability functions) combined with the hypervolume indicator can be used to formulate such set-preferences. A procedure to compute and to maximize the probability that a set of solutions contains at least one satisfactory solution is established. Moreover, we extend the model to the scenario of multiple decision makers. For this we compute the probability that at least one solution in a given set satisfies all decision makers. First, the information required a-priori from the decision makers is considered. Then, a computational procedure to compute the probability for a single set to contain a solution, which is acceptable to all decision makers, is introduced. Thereafter, we discuss how the computational effort can be reduced and how the measure can be maximized. Practical examples for using this in database queries will be discussed, in order to show how this approach relates to applications. [ABSTRACT FROM AUTHOR]
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- 2015
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183. Preliminary Study of Hazardous Materials Management: An Optimization Model in the Context of Green Supply Chain Management.
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Rui Zhao, Neighbour, G., and Deutz, P.
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- 2011
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184. High Spies (or How to Win a Programming Contest).
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Hutchison, David, Kanade, Takeo, Kittler, Josef, Kleinberg, Jon M., Mattern, Friedemann, Mitchell, John C., Naor, Moni, Nierstrasz, Oscar, Rangan, C. Pandu, Steffen, Bernhard, Sudan, Madhu, Terzopoulos, Demetri, Tygar, Doug, Vardi, Moshe Y., Weikum, Gerhard, Crescenzi, Pierluigi, Prencipe, Giuseppe, Pucci, Geppino, Deutz, André, and Vliet, Rudy
- Abstract
We analyse transports between leaves in an edge-weighted tree. We prove under which conditions there exists a transport matching the weights of a given tree. We use this to compute minimum and maximum values for the transport between a given pair of leaves. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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185. Morphology and Stable and Radiogenic Isotope Composition of Pedogenic Carbonates in Late Quaternary Relict Soils, New Mexico, U.S.A.: An Integrated Record of Pedogenic Overprinting
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Deutz, P., primary, Montanez, I. P., additional, and Monger, H. C., additional
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- 2002
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186. Erratum to “Derivation of a palaeoenvironmental record from pedogenic carbonates in buried and relict Quaternary soils, Rio Grande Rift, New Mexico” [Palaeogeogr., Palaeoclimatol., Palaeoecol. 166 (2001) 293–317]
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Deutz, P., primary, Montañez, I.P., additional, Monger, H.C., additional, and Morrison, J., additional
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- 2001
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187. EBL2, a flexible, controlled EUV exposure and surface analysis facility
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Yoshioka, Nobuyuki, te Sligte, Edwin, Koster, Norbert, Molkenboer, Freek, and Deutz, Alex
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- 2016
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188. Development of an optofluidic SERS-based biomedical sensor
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Coté, Gerard L., Walton, Brian, Huang, Po-Jung, Kameoka, Jun, Deutz, Nicolaas, and Coté, Gerard L.
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- 2016
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189. On Reference Point Free Weighted Hypervolume Indicators based on Desirability Functions and their Probabilistic Interpretation.
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Emmerich, Michael T.M., Deutz, André H., and Yevseyeva, Iryna
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The so-called a posteriori approach to optimization with multiple conflicting objective functions is to compute or approximate a Pareto front of solutions. In case of continuous objective functions a finite approximation to this set can be computed. Indicator-based multiobjective optimization algorithms compute solution sets that are optimal with respect to some quality measure on sets, such as the commonly used hypervolume indicator (HI). The HI measures the size of the space that is dominated by a given set of solutions. It has many favorable monotonicity properties but it requires a reference point the choice of which is often done ad-hoc. In this study the concept of set monotonic functions for dominated subsets is introduced. Moreover, this work presents a reference point free hypervolume indicator that uses a density that is derived from the user's preferences expressed as desirability functions. This approach will bias the distribution of the approximation set towards a set that more densely samples highly desirable solutions of the objective space. We show that the Harrington type and the Derringer-Suich type of desirability functions yield definite integrals and that the Harrington type has also the favorable property to provide a set-monotonic function over the set of dominated subspaces. It is shown that for a product type of aggregation the weighted hypervolume indicator is mathematically equivalent with an approach that computes the standard hypervolume indicator after transformation of the axes. In addition a probabilistic interpretation of desirability functions is discussed and how a correlation parameter can be introduced in order to change the aggregation type. Finally, practical guidelines for using the discussed set indicator in multiobjective search, for instance when searching for interesting subsets from a database, are provided. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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190. Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group.
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Deutz, Nicolaas E.P., Bauer, Jürgen M., Barazzoni, Rocco, Biolo, Gianni, Boirie, Yves, Bosy-Westphal, Anja, Cederholm, Tommy, Cruz-Jentoft, Alfonso, Krznariç, Zeljko, Nair, K. Sreekumaran, Singer, Pierre, Teta, Daniel, Tipton, Kevin, and Calder, Philip C.
- Abstract
Summary The aging process is associated with gradual and progressive loss of muscle mass along with lowered strength and physical endurance. This condition, sarcopenia, has been widely observed with aging in sedentary adults. Regular aerobic and resistance exercise programs have been shown to counteract most aspects of sarcopenia. In addition, good nutrition, especially adequate protein and energy intake, can help limit and treat age-related declines in muscle mass, strength, and functional abilities. Protein nutrition in combination with exercise is considered optimal for maintaining muscle function. With the goal of providing recommendations for health care professionals to help older adults sustain muscle strength and function into older age, the European Society for Clinical Nutrition and Metabolism (ESPEN) hosted a Workshop on Protein Requirements in the Elderly, held in Dubrovnik on November 24 and 25, 2013. Based on the evidence presented and discussed, the following recommendations are made (a) for healthy older people, the diet should provide at least 1.0–1.2 g protein/kg body weight/day, (b) for older people who are malnourished or at risk of malnutrition because they have acute or chronic illness, the diet should provide 1.2–1.5 g protein/kg body weight/day, with even higher intake for individuals with severe illness or injury, and (c) daily physical activity or exercise (resistance training, aerobic exercise) should be undertaken by all older people, for as long as possible. [ABSTRACT FROM AUTHOR]
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- 2014
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191. Increased whole body hydroxyproline production as assessed by a new stable isotope technique is associated with hip and spine bone mineral loss in cystic fibrosis.
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Engelen, M.P.K.J., Com, G., and Deutz, N.E.P.
- Abstract
Summary Background & aims Bone mineral loss, reduced lung function and impaired nutritional status are frequently present in children with Cystic Fibrosis (CF). Blood concentrations and urinary excretion of hydroxyproline (OH-PRO) have been used as markers of bone mineral status and lung function in CF. Objective To examine whether whole body hydroxyproline production, as assessed by a new stable isotope methodology, is increased in pediatric patients with CF and associated with bone mineral loss, lung function decline and impaired nutritional status. Design In a cross-sectional study in 15 pediatric patients with CF and 17 healthy young control subjects, whole body hydroxyproline production (Wb OH-PRO) was assessed in the postabsorptive state by primed-constant and continuous infusion of the stable isotope 2-D-OH-PRO for 3 h. Bone mineral density (BMD) of whole body, hip and spin, and body composition (fat mass and fat-free mass) were determined by dual-energy X-ray Absorptiometry (DXA). Plasma isotopic enrichments and OH-PRO concentrations were measured by LC/MS/MS. Results Higher values for WbOH-PRO production and plasma OH-PRO concentrations were found in pediatric CF patients than in the healthy young subjects ( p < 0.001). WbOH-PRO production was significantly correlated with plasma OH-PRO concentrations in the CF ( r : 0.70, p = 0.007) but not in the healthy group. WbOH-PRO production in CF was associated with low BMD values in hip ( r = −0.61, p = 0.02) and spine ( r = −0.59, p = 0.02) but not with whole body BMD, lung function or body composition. Conclusion A new stable isotope approach revealed enhanced levels of whole body hydroxyproline production rate in pediatric patients with CF, indicative of enhanced whole body collagen breakdown. Increased levels for whole body hydroxyproline production in CF were associated with severe bone mineral loss in hip and spine but not with lung function decline or impaired nutritional status. Registration ClinicalTrials.gov = NCT01172301 [ABSTRACT FROM AUTHOR]
- Published
- 2014
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192. New stable isotope method to measure protein digestibility and response to pancreatic enzyme intake in cystic fibrosis.
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Engelen, M.P.K.J., Com, G., Anderson, P.J., and Deutz, N.E.P.
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Summary Background & aims Adequate protein intake and digestion are necessary to prevent muscle wasting in cystic fibrosis (CF). Accurate and easy-to-use methodology to quantify protein maldigestion is lacking in CF. Objective To measure protein digestibility and the response to pancreatic enzyme intake in CF by using a new stable isotope methodology. Design In 19 CF and 8 healthy subjects, protein digestibility was quantified during continuous (sip) feeding for 6 h by adding 15 N-labeled spirulina protein and L-[ring- 2 H 5 ]phenylalanine (PHE) to the nutrition and measuring plasma ratio [ 15 N]PHE to [ 2 H 5 ]PHE. Pancreatic enzymes were ingested after 2 h in CF and the response in protein digestibility was assessed. To exclude difference in mucosal function, postabsorptive whole-body citrulline (CIT) production rate was measured by L-[5- 13 C-5,5- 2 H 2 ]-CIT pulse and blood samples were taken to analyze tracer-tracee ratios. Results Protein digestibility was severely reduced in the CF group (47% of healthy subjects; P < 0.001). Intake of pancreatic enzymes induced a slow increase in protein digestibility in CF until 90% of values obtained by healthy subjects. Maximal digestibility was reached at 100 min and maintained for 80 min. Stratification into CF children ( n = 10) and adults showed comparable values for protein digestibility and similar kinetic responses to pancreatic enzyme intake. Whole-body citrulline production was elevated in CF indicating preserved mucosal function. Conclusion Protein digestibility is severely compromised in patients with CF as measured by this novel and easy-to-use stable isotope approach. Pancreatic enzymes are able to normalize protein digestibility in CF, albeit with a severe delay. Registration ClinicalTrials.gov = NCT01494909 . [ABSTRACT FROM AUTHOR]
- Published
- 2014
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193. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion.
- Author
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Jonker, Renate, Deutz, Nicolaas E.P., Erbland, Marcia L., Anderson, Paula J., and Engelen, Mariëlle P.K.J.
- Abstract
Summary: Background & aims: Muscle wasting commonly occurs in COPD, negatively affecting outcome. The aim was to examine the net whole-body protein synthesis response to two milk protein meals with comparable absorption rates (hydrolyzed casein (hCAS) vs. hydrolyzed whey (hWHEY)) and the effects of co-ingesting leucine. Methods: Twelve COPD patients (GOLD stage II–IV) with nutritional depletion, were studied following intake of a 15 g hCAS or hWHEY protein meal with or without leucine-co-ingestion, according to a double-blind randomized cross-over design. The isotopic tracers L-[ring-
2 H5 ]-Phenylalanine, L-[ring-2 H2 ]-Tyrosine, L-[2 H3 ]-3-Methylhistidine (given via continuous intravenous infusion), and L-[15 N]-Phenylalanine (added to the protein meals) were used to measure endogenous whole-body protein breakdown (WbPB), whole-body protein synthesis (WbPS), net protein synthesis (NetPS), splanchnic extraction and myofibrillar protein breakdown (MPB). Analyses were done in arterialized-venous plasma by LC/MS/MS. Results: WbPS was greater after intake of the hCAS protein meal (P < 0.05) whereas the hWHEY protein meal reduced WbPB more (P < 0.01). NetPS was stimulated comparably, with a protein conversion rate greater than 70%. Addition of leucine did not modify the insulin, WbPB, WbPS or MPB response. Conclusions: Hydrolyzed casein and whey protein meals comparably and efficiently stimulate whole-body protein anabolism in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. This trial was registered at clinicaltrials.gov as NCT01154400. [Copyright &y& Elsevier]- Published
- 2014
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194. Membrane extraction in native lipid nanodiscs reveals dynamic regulation of Cdc42 complexes during cell polarization
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Deutz, Lars N., Sarıkaya, Sena, and Dickinson, Daniel J.
- Abstract
Embryonic development requires the establishment of cell polarity to enable cell fate segregation and tissue morphogenesis. This process is regulated by Par complex proteins, which partition into polarized membrane domains and direct downstream polarized cell behaviors. The kinase aPKC (along with its cofactor Par6) is a key member of this network and can be recruited to the plasma membrane by either the small GTPase Cdc42 or the scaffolding protein Par3. Although in vitro interactions among these proteins are well established, much is still unknown about the complexes they form during development. Here, to enable the study of membrane-associated complexes ex vivo, we used a maleic acid copolymer to rapidly isolate membrane proteins from single C. eleganszygotes into lipid nanodiscs. We show that native lipid nanodisc formation enables detection of endogenous complexes involving Cdc42, which are undetectable when cells are lysed in detergent. We found that Cdc42 interacts more strongly with aPKC/Par6 during polarity maintenance than polarity establishment, two developmental stages that are separated by only a few minutes. We further show that Cdc42 and Par3 do not bind aPKC/Par6 simultaneously, confirming recent in vitro findings in an ex vivo context. Our findings establish a new tool for studying membrane-associated signaling complexes and reveal an unexpected mode of polarity regulation via Cdc42.
- Published
- 2023
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195. Presenilin‐I polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type
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Bornebroek, M., primary, Haan, J., additional, Backhovens, H., additional, Deutz, P., additional, Van Buchem, M. A., additional, van den Broeck, M., additional, Bakker, E., additional, Roos, R. A. C., additional, and Van Broeckhoven, C., additional
- Published
- 1997
- Full Text
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196. Protein anabolic resistance in cancer: does it really exist?
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Engelen, Mariëlle P.K.J., van der Meij, Barbara S., and Deutz, Nicolaas E.P.
- Published
- 2016
- Full Text
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197. Detection of fast flying nanoparticles by light scattering over a large volume
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Bodermann, Bernd, Frenner, Karsten, Silver, Richard M., Pettazzi, F., Bäumer, S., van der Donck, J., and Deutz, A.
- Published
- 2015
- Full Text
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198. Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults.
- Author
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Deutz, Nicolaas E.P., Pereira, Suzette L., Hays, Nicholas P., Oliver, Jeffery S., Edens, Neile K., Evans, Chris M., and Wolfe, Robert R.
- Abstract
Summary: Background: Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults. Objective: To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults during complete bed rest. Design: A randomized, controlled, double-blinded, parallel-group design study was carried out in 24 healthy (SPPB ≥ 9) older adult subjects (20 women, 4 men), confined to complete bed rest for ten days, followed by resistance training rehabilitation for eight weeks. Subjects in the experimental group were treated with HMB (calcium salt, 1.5 g twice daily – total 3 g/day). Control subjects were treated with an inactive placebo powder. Treatments were provided starting 5 days prior to bed rest till the end rehabilitation phase. DXA was used to measure body composition. Results: Nineteen eligible older adults (BMI: 21–33; age: 60–76 year) were evaluable at the end of the bed rest period (Control n = 8; Ca-HMB n = 11). Bed rest caused a significant decrease in total lean body mass (LBM) (2.05 ± 0.66 kg; p = 0.02, paired t-test) in the Control group. With the exclusion of one subject, treatment with HMB prevented the decline in LBM over bed rest −0.17 ± 0.19 kg; p = 0.23, paired t-test). There was a statistically significant difference between treatment groups for change in LBM over bed rest (p = 0.02, ANOVA). Sub-analysis on female subjects (Control = 7, HMB = 8) also revealed a significant difference in change in LBM over bed rest between treatment groups (p = 0.04, ANOVA). However, differences in function parameters could not be observed, probably due to the sample size of the study. Conclusions: In healthy older adults, HMB supplementation preserves muscle mass during 10 days of bed rest. These results need to be confirmed in a larger trial. This trial is registered at http://ClinicalTrials.gov under NCT00945581. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
199. »Bauen Sie eigentlich auch Instrumente, mit denen man richtige Musik machen kann?« Zum Verhältnis von Instrumentenbau und Musiktherapie.
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Deutz, Bernhard
- Published
- 2013
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200. Is there a maximal anabolic response to protein intake with a meal?
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Deutz, Nicolaas E. and Wolfe, Robert R.
- Abstract
Summary: Several recent publications indicate that the maximum stimulation of muscle protein fractional synthetic rate occurs with intake of 20–30 g protein. This finding has led to the concept that there is a maximal anabolic response to protein intake with a meal, and that the normal amount of protein eaten with dinner will generally exceed the maximally-effective intake of protein. However, protein breakdown has not been taken into account when evaluating the anabolic response to protein intake. Protein anabolism occurs only when protein synthesis exceeds protein breakdown. Higher protein intakes when protein synthesis is maximized is characterized by suppressed protein breakdown and via that mechanism leads to a greater anabolic response. This explains why when net protein synthesis is measured, the relationship between amino acid availability and net gain remains linear, without any apparent plateau of effect at higher levels of availability. We conclude that there is no practical upper limit to the anabolic response to protein or amino acid intake in the context of a meal. [Copyright &y& Elsevier]
- Published
- 2013
- Full Text
- View/download PDF
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