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156. Commento agli articoli 75-81 c.p.c., Delle parti, in Codice di procedura civile. Commentario diretto da Claudio Consolo. Vol. 1

Author

Abatangelo, Chiara, Arria, Giulio, Azzarello, Severa, Baccaglini, Laura, Barletta, Antonino, Baroncini, Valentina, Barone, Sara, Benigni, Elena, Berloni, Ugo, Bertoldi, Valentina, Bertollini, Paolo, Boccagna, Salvatore, Bonafine, Alessio, Buonafede, Alice, Campus, Marco, Capponi, Bruno, Caprio, Sara, Chizzini, Augusto, Consolo, Claudio, D'Ascola, Pasquale, Dalfino, Domenico, Dalla Bontà Silvana, De Angelis Francesca, De Cristofaro Marco, De Propris Luigi, De Santis di Nicola Francesco, Di Cola Livia, Di Nanni Luigi, F., Donzelli, Romolo, Fabbi, Alessandro, Fabiani, Massimo, Ferrari, Francesca, Ferri Alessia Francesca, Frasca, Eugenio, Frassinetti, Alessandra, Gasperini Maria Pia, Giacomelli, Marco, Gioia, Gina, Gobbati, Giulio, Godio, Federica, Gradi, Marco, Grippo, Paola, Izzo, Silvia, Lai, Piergiuseppe, Lanni Pier Paolo, Lombardi, Rita, Marinelli, Marino, Mastantuono, Angela, Mastracchio, Chiara, Mastrangelo, Giovanni, Merlin, Elena, Metafora, Roberta, Montanari, Massimo, Murino, Filippo, Muroni, Raffaella, Nappi, Pasquale, Negri, Angela, Onniboni, Claudia, Pagni, Ilaria, Panetta, Francesca, Panzarola, Andrea, Paoletti, Andrea, Parisi, Antonella, Parravicini, Simone, Penasa, Luca, Perago, Carmela, Petrella, Virginia, Petrillo, Chiara, Piccininni, Leo, Pilloni, Monica, Pinto, Federica, Poli, Roberto, Polinari, Jacopo, Poliseno, Barbara, Porcelli, Federica, Pototschnig, Paolo, Prendini, Luca, Raganati, Antonella, Ravidà, Fabrizio, Recchioni, Stefano, Rizzardo, Dora, Romano, Alberto, Ruggieri Paola Chiara, Rusciano, Silvia, Salvioni, Teresa, Savino, Fabio, Scala, Angelo, Serra Maria Luisa, Sotghiu, Nicola, Spaccapelo, Chiara, Stella, Marcello, Storto, Alfredo, Stropparo, Alberto, Tedoldi, Alberto, Teresi, Massimo, Trinchi, Alessandro, Tripaldi, Valentina, Turatto, Silvia, Vanzetti, Michelle, Villa, Alberto, Vullo, Enzo, Widmann, Paola, and Zuffi, Beatrice

Subjects
Diritto processuale civile, Parti, capacità, legittimazione, rappresentanza, sostituzione, Diritto processuale civile, sostituzione, legittimazione, capacità, Parti, NO, rappresentanza
Published
2018

157. Commento agli articoli 90-98 c.p.c., Delle responsabilità delle parti per le spese e per i danni processuali

Author

Abatangelo, Chiara, Arria, Giulio, Azzarello, Severa, Baccaglini, Laura, Barletta, Antonino, Baroncini, Valentina, Barone, Sara, Benigni, Elena, Berloni, Ugo, Bertoldi, Valentina, Bertollini, Paolo, Boccagna, Salvatore, Bonafine, Alessio, Buonafede, Alice, Campus, Marco, Capponi, Bruno, Caprio, Sara, Chizzini, Augusto, Consolo, Claudio, D'Ascola, Pasquale, Dalfino, Domenico, Dalla Bontà Silvana, De Angelis Francesca, De Cristofaro Marco, De Propris Luigi, De Santis di Nicola Francesco, Di Cola Livia, Di Nanni Luigi, F., Donzelli, Romolo, Fabbi, Alessandro, Fabiani, Massimo, Ferrari, Francesca, Ferri Alessia Francesca, Frasca, Eugenio, Frassinetti, Alessandra, Gasperini Maria Pia, Giacomelli, Marco, Gioia, Gina, Gobbati, Giulio, Godio, Federica, Gradi, Marco, Grippo, Paola, Izzo, Silvia, Lai, Piergiuseppe, Lanni Pier Paolo, Lombardi, Rita, Marinelli, Marino, Mastantuono, Angela, Mastracchio, Chiara, Mastrangelo, Giovanni, Merlin, Elena, Metafora, Roberta, Montanari, Massimo, Murino, Filippo, Muroni, Raffaella, Nappi, Pasquale, Negri, Angela, Onniboni, Claudia, Pagni, Ilaria, Panetta, Francesca, Panzarola, Andrea, Paoletti, Andrea, Parisi, Antonella, Parravicini, Simone, Penasa, Luca, Perago, Carmela, Petrella, Virginia, Petrillo, Chiara, Piccininni, Leo, Pilloni, Monica, Pinto, Federica, Poli, Roberto, Polinari, Jacopo, Poliseno, Barbara, Porcelli, Federica, Pototschnig, Paolo, Prendini, Luca, Raganati, Antonella, Ravidà, Fabrizio, Recchioni, Stefano, Rizzardo, Dora, Romano, Alberto, Ruggieri Paola Chiara, Rusciano, Silvia, Salvioni, Teresa, Savino, Fabio, Scala, Angelo, Serra Maria Luisa, Sotghiu, Nicola, Spaccapelo, Chiara, Stella, Marcello, Storto, Alfredo, Stropparo, Alberto, Tedoldi, Alberto, Teresi, Massimo, Trinchi, Alessandro, Tripaldi, Valentina, Turatto, Silvia, Vanzetti, Michelle, Villa, Alberto, Vullo, Enzo, Widmann, Paola, and Zuffi, Beatrice

Subjects
spese processuali, Diritto processuale civile, responsabilità aggravata, Diritto processuale civile, spese processuali, responsabilità aggravata, NO
Published
2018

158. Commento agli articoli 88-89 c.p.c., Dei doveri delle parti e dei difensori

Author

Abatangelo, Chiara, Arria, Giulio, Azzarello, Severa, Baccaglini, Laura, Barletta, Antonino, Baroncini, Valentina, Barone, Sara, Benigni, Elena, Berloni, Ugo, Bertoldi, Valentina, Bertollini, Paolo, Boccagna, Salvatore, Bonafine, Alessio, Buonafede, Alice, Campus, Marco, Capponi, Bruno, Caprio, Sara, Chizzini, Augusto, Consolo, Claudio, D'Ascola, Pasquale, Dalfino, Domenico, Dalla Bontà Silvana, De Angelis Francesca, De Cristofaro Marco, De Propris Luigi, De Santis di Nicola Francesco, Di Cola Livia, Di Nanni Luigi, F., Donzelli, Romolo, Fabbi, Alessandro, Fabiani, Massimo, Ferrari, Francesca, Ferri Alessia Francesca, Frasca, Eugenio, Frassinetti, Alessandra, Gasperini Maria Pia, Giacomelli, Marco, Gioia, Gina, Gobbati, Giulio, Godio, Federica, Gradi, Marco, Grippo, Paola, Izzo, Silvia, Lai, Piergiuseppe, Lanni Pier Paolo, Lombardi, Rita, Marinelli, Marino, Mastantuono, Angela, Mastracchio, Chiara, Mastrangelo, Giovanni, Merlin, Elena, Metafora, Roberta, Montanari, Massimo, Murino, Filippo, Muroni, Raffaella, Nappi, Pasquale, Negri, Angela, Onniboni, Claudia, Pagni, Ilaria, Panetta, Francesca, Panzarola, Andrea, Paoletti, Andrea, Parisi, Antonella, Parravicini, Simone, Penasa, Luca, Perago, Carmela, Petrella, Virginia, Petrillo, Chiara, Piccininni, Leo, Pilloni, Monica, Pinto, Federica, Poli, Roberto, Polinari, Jacopo, Poliseno, Barbara, Porcelli, Federica, Pototschnig, Paolo, Prendini, Luca, Raganati, Antonella, Ravidà, Fabrizio, Recchioni, Stefano, Rizzardo, Dora, Romano, Alberto, Ruggieri Paola Chiara, Rusciano, Silvia, Salvioni, Teresa, Savino, Fabio, Scala, Angelo, Serra Maria Luisa, Sotghiu, Nicola, Spaccapelo, Chiara, Stella, Marcello, Storto, Alfredo, Stropparo, Alberto, Tedoldi, Alberto, Teresi, Massimo, Trinchi, Alessandro, Tripaldi, Valentina, Turatto, Silvia, Vanzetti, Michelle, Villa, Alberto, Vullo, Enzo, Widmann, Paola, and Zuffi, Beatrice

Subjects
Diritto processuale civile, Parti, Doveri, Diritto processuale civile, Parti, Doveri, NO
Published
2018

160. Commento agli articoli 267-272 c.p.c., Dell’intervento di terzi

Author

Abatangelo, Chiara, Arria, Giulio, Azzarello, Severa, Baccaglini, Laura, Barletta, Antonino, Baroncini, Valentina, Barone, Sara, Benigni, Elena, Berloni, Ugo, Bertoldi, Valentina, Bertollini, Paolo, Boccagna, Salvatore, Bonafine, Alessio, Buonafede, Alice, Campus, Marco, Capponi, Bruno, Caprio, Sara, Chizzini, Augusto, Consolo, Claudio, D'Ascola, Pasquale, Dalfino, Domenico, Dalla Bontà Silvana, De Angelis Francesca, De Cristofaro Marco, De Propris Luigi, De Santis di Nicola Francesco, Di Cola Livia, Di Nanni Luigi, F., Donzelli, Romolo, Fabbi, Alessandro, Fabiani, Massimo, Ferrari, Francesca, Ferri Alessia Francesca, Frasca, Eugenio, Frassinetti, Alessandra, Gasperini Maria Pia, Giacomelli, Marco, Gioia, Gina, Gobbati, Giulio, Godio, Federica, Gradi, Marco, Grippo, Paola, Izzo, Silvia, Lai, Piergiuseppe, Lanni Pier Paolo, Lombardi, Rita, Marinelli, Marino, Mastantuono, Angela, Mastracchio, Chiara, Mastrangelo, Giovanni, Merlin, Elena, Metafora, Roberta, Montanari, Massimo, Murino, Filippo, Muroni, Raffaella, Nappi, Pasquale, Negri, Angela, Onniboni, Claudia, Pagni, Ilaria, Panetta, Francesca, Panzarola, Andrea, Paoletti, Andrea, Parisi, Antonella, Parravicini, Simone, Penasa, Luca, Perago, Carmela, Petrella, Virginia, Petrillo, Chiara, Piccininni, Leo, Pilloni, Monica, Pinto, Federica, Poli, Roberto, Polinari, Jacopo, Poliseno, Barbara, Porcelli, Federica, Pototschnig, Paolo, Prendini, Luca, Raganati, Antonella, Ravidà, Fabrizio, Recchioni, Stefano, Rizzardo, Dora, Romano, Alberto, Ruggieri Paola Chiara, Rusciano, Silvia, Salvioni, Teresa, Savino, Fabio, Scala, Angelo, Serra Maria Luisa, Sotghiu, Nicola, Spaccapelo, Chiara, Stella, Marcello, Storto, Alfredo, Stropparo, Alberto, Tedoldi, Alberto, Teresi, Massimo, Trinchi, Alessandro, Tripaldi, Valentina, Turatto, Silvia, Vanzetti, Michelle, Villa, Alberto, Vullo, Enzo, Widmann, Paola, and Zuffi, Beatrice

Subjects
processo di cognizione, Diritto processuale civile, Diritto processuale civile, processo di cognizione, parti, intervento di terzi, parti, intervento di terzi, NO
Published
2018

161. Codice di procedura civile. Commentario diretto da Claudio Consolo, VI ed., IPSOA - gruppo Wolters Kluwer, Tomo I

Author

Abatangelo, Chiara, Arria, Giulio, Azzarello, Severa, Baccaglini, Laura, Barletta, Antonino, Baroncini, Valentina, Barone, Sara, Benigni, Elena, Berloni, Ugo, Bertoldi, Valentina, Bertollini, Paolo, Boccagna, Salvatore, Bonafine, Alessio, Buonafede, Alice, Campus, Marco, Capponi, Bruno, Caprio, Sara, Chizzini, Augusto, Consolo, Claudio, D'Ascola, Pasquale, Dalfino, Domenico, Dalla Bontà Silvana, De Angelis Francesca, De Cristofaro Marco, De Propris Luigi, De Santis di Nicola Francesco, Di Cola Livia, Di Nanni Luigi, F., Donzelli, Romolo, Fabbi, Alessandro, Fabiani, Massimo, Ferrari, Francesca, Ferri Alessia Francesca, Frasca, Eugenio, Frassinetti, Alessandra, Gasperini Maria Pia, Giacomelli, Marco, Gioia, Gina, Gobbati, Giulio, Godio, Federica, Gradi, Marco, Grippo, Paola, Izzo, Silvia, Lai, Piergiuseppe, Lanni Pier Paolo, Lombardi, Rita, Marinelli, Marino, Mastantuono, Angela, Mastracchio, Chiara, Mastrangelo, Giovanni, Merlin, Elena, Metafora, Roberta, Montanari, Massimo, Murino, Filippo, Muroni, Raffaella, Nappi, Pasquale, Negri, Angela, Onniboni, Claudia, Pagni, Ilaria, Panetta, Francesca, Panzarola, Andrea, Paoletti, Andrea, Parisi, Antonella, Parravicini, Simone, Penasa, Luca, Perago, Carmela, Petrella, Virginia, Petrillo, Chiara, Piccininni, Leo, Pilloni, Monica, Pinto, Federica, Poli, Roberto, Polinari, Jacopo, Poliseno, Barbara, Porcelli, Federica, Pototschnig, Paolo, Prendini, Luca, Raganati, Antonella, Ravidà, Fabrizio, Recchioni, Stefano, Rizzardo, Dora, Romano, Alberto, Ruggieri Paola Chiara, Rusciano, Silvia, Salvioni, Teresa, Savino, Fabio, Scala, Angelo, Serra Maria Luisa, Sotghiu, Nicola, Spaccapelo, Chiara, Stella, Marcello, Storto, Alfredo, Stropparo, Alberto, Tedoldi, Alberto, Teresi, Massimo, Trinchi, Alessandro, Tripaldi, Valentina, Turatto, Silvia, Vanzetti, Michelle, Villa, Alberto, Vullo, Enzo, Widmann, Paola, and Zuffi, Beatrice

Subjects
Diritto processuale civile, Diritto processuale civile, difensori, procura alle liti, difensori, procura alle liti, NO
Published
2018

175. Cutaneous granulomatosis and combined immunodeficiency revealing Ataxia-Telangiectasia: a case report

Author

Antoccia Antonio, Ferrari Francesca, Angelino Giulia, Scarselli Alessia, Folgori Laura, Chessa Luciana, and Finocchi Andrea

Subjects
Pediatrics, RJ1-570
Abstract

Abstract Ataxia-telangiectasia (A-T) is a complex multisystem disorder characterized by progressive neurological impairment, variable immunodeficiency and oculo-cutaneous telangiectasia. A-T is a member of chromosomal breakage syndromes and it is caused by a mutation in the ataxia-telangiectasia mutated (ATM) gene. Because of a wide clinical heterogeneity, A-T is often difficult to diagnose in children. We report an unusual case of a 3-year-old boy affected by A-T who presented exclusively with extensive cutaneous granulomatosis and severe combined immunodeficiency, without neurological abnormalities, at the time of diagnosis. This case clearly emphasizes the variable presentation of A-T syndrome and highlights the difficulties in the early diagnosis of A-T. A-T should be considered in children with evidence of combined humoral and cellular immunodeficiency associated with unexplained skin granulomatous lesions, even in the absence of the classic features of this syndrome.

Published
2010
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177. Flagellin From Pseudomonas Aeruginosa Stimulates ATB0,+ Transporter for Arginine and Neutral Amino Acids in Human Airway Epithelial Cells.

Author

Barilli, Amelia, Visigalli, Rossana, Ferrari, Francesca, Borsani, Giuseppe, Dall'Asta, Valeria, and Rotoli, Bianca Maria

Subjects
AMINO acids, EPITHELIAL cells, ESSENTIAL amino acids, FLAGELLIN, ARGININE
Abstract

At present, the central role played by arginine in the modulation of the inflammatory cellular responses is well-recognized, and many pro-inflammatory stimuli are known to modulate the expression and activity of its transmembrane transporters. In this regard, we have addressed the effects of bacterial flagellin from Pseudomonas aeruginosa (FLA-PA) on the uptake of the amino acid in human epithelial respiratory cells. Among the arginine transporters, only ATB0,+, y+L, and y+ were operative in bronchial epithelial Calu-3 cells under control conditions; however, only the expression and activity of ATB0,+ were stimulated upon incubation with flagellin, whereas those of systems y+L and y+ were not stimulated. As a result, this induction, in turn, led to an increase in the intracellular content of arginine without making any change to its metabolic pathway. In addition, flagellin upregulated the amount of other amino acids substrates of ATB0,+, in particular, all the essential amino acids, such as valine, isoleucine, and leucine, along with the non-essential glutamine. At the molecular level, these effects were directly referable to the stimulation of a toll-like receptor-5 (TLR5) signaling pathway and to the induction of nuclear factor-κB (NF-κB) transcription factor. An induction of ATB0,+ expression has been observed also in EpiAirway™, a model of primary human normal tracheal-bronchial epithelial cells that mimics the in vitro pseudostratified columnar epithelium of the airways. In this tissue model, the incubation with flagellin is associated with the upregulation of messenger RNAs (mRNAs) for the chemokine IL-8 and for the cytokines IL-6 and interleukin-1β (IL-1β); as for the latter, a marked secretion in the extracellular medium was also observed due to the concomitant activation of caspase-1. The overall findings indicate that, in human respiratory epithelium, flagellin promotes cellular responses associating the increase of intracellular amino acids through ATB0,+ with the activation of the inflammasome. Given the role of the ATB0,+ transporter as a delivery system for bronchodilators in human airway epithelial cells, its induction under inflammatory conditions gains particular relevance in the field of respiratory pharmacology. [ABSTRACT FROM AUTHOR]

Published
2021
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178. "Achieve the best while rushing against time": A grounded theory study on caring for low-income immigrant cancer patients at end of life.

Author

Sacchi, Simona, Capone, Roberto, Ferrari, Francesca, Sforacchi, Federica, Di Leo, Silvia, and Ghirotto, Luca

Subjects
ATTITUDE (Psychology), CANCER patient psychology, PSYCHOLOGY of caregivers, GROUNDED theory, HOSPITALS, PSYCHOLOGY of immigrants, MATHEMATICAL models, MEDICAL needs assessment, MEDICAL quality control, MEDICAL personnel, PATIENT-professional relations, PALLIATIVE treatment, POVERTY, TERMINAL care, COMPASSION, THEORY, EXTENDED families, OCCUPATIONAL roles, PSYCHOSOCIAL factors, SOCIOECONOMIC factors, CULTURAL competence, CAREGIVER attitudes, FAMILY attitudes
Abstract

Background: Between 2000 and 2020, Europe experienced an annual net arrival of approximately 1.6 million immigrants per year. While having lower mortality rates, in the setting of severe diseases, immigrants bear a greater cancer-related burden due to linguistic and cultural barriers and socio-economic conditions. Professionals face a two-fold task: managing clinical conditions while considering the social, economic, cultural, and spiritual sphere of patients and their families. In this regard, little is known about the care provision to low-income immigrant cancer patients in real contexts. Aim: To investigate the perspective of professionals, family members, and stakeholders on the caring process of low-income immigrant cancer patients at the end of life. Design: A Constructivist Grounded Theory study. Setting/participants: The study, conducted at a Hospital in Northern Italy, involved 27 participants among health professionals, family caregivers, and other stakeholders who had recently accompanied immigrant cancer patients in their terminal phase of illness. Results: Findings evidenced that professionals feel they were not adequately trained to cope with immigrant cancer patients, nonetheless, they were highly committed in providing the best care they could, rushing against the (short) time the patients have left. Analyses evidenced four main categories: "providing and receiving hospitality," "understanding each other," "addressing diversity," and "around the patient," which we conceptualized under the core category "Achieve the best while rushing against time." Conclusions: The model reveals the activation of empathic and compassionate behavior by professionals. It evidences the need for empowering professionals with cultural competencies by employing interpreters and specific training programs. [ABSTRACT FROM AUTHOR]

Published
2021
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179. Solubility And Durability Of Cardanol Derived Plasticizers For Soft PVC

Author

FERRARI, FRANCESCA, MAFFEZZOLI, Alfonso, GRECO, Antonio, Ferrari, Francesca, Maffezzoli, Alfonso, and Greco, Antonio

Subjects
cardanol, plasticizer, PVC
Abstract

This work was aimed to test the suitability of an epoxidized cardanol derived plasticizer for the production of soft PVC characterized by low environmental and toxicological impact soft PVC. Nowadays, the use of natural derived plasticizer in soft PVC industry is emerging as valid alternative towards conventional phthalate plasticizers, in order to reduce the environmental and toxicological impact of soft PVC. In facts, cardanol is a natural and renewable resource, characterized by a wide worldwide availability. In addition, being derived from cashew nut shell liquid, which is a by-product of cashew nut shell industry, it does not contribute to the subtraction of resources from the food chain, in contrast, for example, to epoxidized soybean oil. To this purpose, soft PVC samples were produced in an industrial plant, using both cardanol derived and phthalate plasticizer. Thermal and mechanical characterization showed that the properties of PVC plasticized by cardanol derivative are comparable to those of soft PVC obtained by phthalate, which is a clear indication of the good plasticizing effectiveness of cardanol derivative, and highlights its potential for the production of soft PVC characterized by reduced environmental and toxicological impact.

Published
2016

181. Use Of Cardanol Derivatives As Plasticizers For PVC

Author

MAFFEZZOLI, Alfonso, FERRARI, FRANCESCA, DEL SOLE, Roberta, GRECO, Antonio, Maffezzoli, Alfonso, Ferrari, Francesca, DEL SOLE, Roberta, and Greco, Antonio

Subjects
plasticizer, cardanol , epoxidation
Abstract

This work is aimed to study the suitability of cardanol derivatives as plasticizers for poly(vinyl chloride), (PVC). The plasticizers are obtained by chemical modification of cardanol, a natural, renewable resource, obtained as a by-product of the cashew nut shell industry. Due to the choice of environmentally friendly chemical modification routes, partial conversion of cardanol to the target compounds was obtained. Consequently, the tested plasticizers were composed of a mixture of different cardanol derivatives. Rheological tests on PVC plastisols obtained with neat cardanol showed that cardanol must be subjected to chemical modifications, such as acetylation and epoxidation, in order to perform as an effective plasticizer. In particular, only after epoxidation, does the cardanol derivative become fully soluble in PVC. PVC plastisols obtained with such cardanol derivatives present a similar gelation temperature compared to bis (2-ethylhexyl) phthalate (DEHP) based plastisols. Mechanical properties of the flexible PVC produced by the addition of cardanol derived plasticizer after epoxidation are also comparable to those attained by the use of DEHP. Nevertheless ageing tests showed an accelerated migration of cardanol derived plasticizer, attributed to the loss of unreacted cardanol present in the plasticizer, which was in turn responsible for a significantly faster degradation of the properties, compared to flexible PVC containing DEHP. This highlights the relevance of achieving a high yield of the acetylation and epoxidation reactions, which is a relevant issue of the future research and development activities in this field.

Published
2016

182. Five-year relative survival by stage of breast and colon cancers in Italy

Author

Mangone, Lucia, Mancuso, Pamela, Bisceglia, Isabella, Braghiroli, Barbara, Ferrari, Francesca, Vicentini, Massimo, and Giorgi Rossi, Paolo

Abstract

Objective: To present the changes in 5-year relative survival of patients with breast and colorectal cancer in a northern Italian province in the 2000–2012 period. Changes are presented in relation to stage, period, and age in the screening population.Methods: A total of 5073 breast cancer and 4093 colorectal cancer cases were registered. Breast cancer was divided into 5 age groups: <45, 45–49, 50–69, 70–74 (the target screening population is ages 45–74), and >74 years. Colorectal cancers were classified into 3 age groups: <50, 50–69 (screening target population), and >69 years. Survival was analysed by stage, period, and screening program.Results: Five-year breast cancer relative survival was 92.9% overall, with 100%, 91.9%, 78.8%, 34.2%, and 76.4% for stages I, II, III, IV, and unknown, respectively. Survival increased from 89.7%, 91.8%, and 93.4%, respectively, in the periods 2000–2005, 2006–2009, and 2010–2012. Breast cancer survival was stable in early stages (although already high); a slight improvement was seen for stages III and IV. Five-year colorectal cancer relative survival was 63.6% overall, with 93.3%, 78.6%, 69.8%, 13.2%, and 55.8% for stages I, II, III, IV, and unknown, respectively. No improvement in survival was seen in the periods analysed, although the introduction of screening in 2005 did lead to a sharp decrease in incidence and mortality.Conclusions: For breast cancer, extending the screening target age led to an improvement in survival; for colorectal cancer, the best impact was on incidence and mortality rate.

Published
2021
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186. Functional analysis of OCTN2 and ATB0,+ in normal human airway epithelial cells.

Author

Rotoli, Bianca Maria, Visigalli, Rossana, Barilli, Amelia, Ferrari, Francesca, Bianchi, Massimiliano G., Di Lascia, Maria, Riccardi, Benedetta, Puccini, Paola, and Dall'Asta, Valeria

Subjects
EPITHELIAL cells, FUNCTIONAL analysis, ESSENTIAL fatty acids, DRUG delivery systems, MOUNTAIN biking
Abstract

In human, OCTN2 (SLC22A5) and ATB0,+ (SLC6A14) transporters mediate the uptake of L-carnitine, essential for the transport of fatty acids into mitochondria and the subsequent degradation by β-oxidation. Aim of the present study was to characterize L-carnitine transport in EpiAirway™, a 3D organotypic in vitro model of primary human tracheal-bronchial epithelial cells that form a fully differentiated, pseudostratified columnar epithelium at air-liquid interface (ALI) condition. In parallel, Calu-3 monolayers grown at ALI for different times (8d or 21d of culture) were used as comparison. OCTN2 transporter was equally expressed in both models and functional at the basolateral side. ATB0,+ was, instead, highly expressed and active on the apical membrane of EpiAirway™ and only in early-cultures of Calu-3 (8d but not 21d ALI). In both cell models, L-carnitine uptake on the apical side was significantly inhibited by the bronchodilators glycopyrrolate and tiotropium, that hence can be considered substrates of ATB0,+; ipratropium was instead effective on the basolateral side, indicating its interaction with OCTN2. Inflammatory stimuli, such as LPS or TNFα, caused an induction of SLC6A14/ATB0,+ expression in Calu-3 cells, along with a 2-fold increase of L-carnitine uptake only at the apical side; on the contrary SLC22A5/OCTN2 was not affected. As both OCTN2 and ATB0,+, beyond transporting L-carnitine, have a significant potential as delivery systems for drugs, the identification of these transporters in EpiAirway™ can open new fields of investigation in the study of drug inhalation and pulmonary delivery. [ABSTRACT FROM AUTHOR]

Published
2020
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187. y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.

Author

Rotoli, Bianca Maria, Barilli, Amelia, Visigalli, Rossana, Ferrari, Francesca, and Dall'Asta, Valeria

Subjects
EPITHELIAL cells, AMINO acids, PROTEINS, FOOD intolerance, PROTEIN microarrays
Abstract

y+LAT1 (encoded by SLC7A7), together with y+LAT2 (encoded by SLC7A6), is the alternative light subunits composing the heterodimeric transport system y+L for cationic and neutral amino acids. SLC7A7 mutations cause lysinuric protein intolerance (LPI), an inherited multisystem disease characterized by low plasma levels of arginine and lysine, protein‐rich food intolerance, failure to thrive, hepatosplenomegaly, osteoporosis, lung involvement, kidney failure, haematologic and immunological disorders. The reason for the heterogeneity of LPI symptoms is thus far only poorly understood. Here, we aimed to quantitatively compare the expression of SLC7A7 and SLC7A6 among different human cell types and evaluate y+LAT1 and y+LAT2 contribution to arginine transport. We demonstrate that system y+L‐mediated arginine transport is mainly accounted for by y+LAT1 in monocyte‐derived macrophages (MDM) and y+LAT2 in fibroblasts. The kinetic analysis of arginine transport indicates that y+LAT1 and y+LAT2 share a comparable affinity for the substrate. Differences have been highlighted in the expression of SLC7A6 and SLC7A7 mRNA among different cell models: while SLC7A6 is almost equally expressed, SLC7A7 is particularly abundant in MDM, intestinal Caco‐2 cells and human renal proximal tubular epithelial cells (HRPTEpC). The characterization of arginine uptake demonstrates that system y+L is operative in renal cells and in Caco‐2 where, at the basolateral side, it mediates arginine efflux in exchange with leucine plus sodium. These findings explain the defective absorption/reabsorption of arginine in LPI. Moreover, y+LAT1 is the prevailing transporter in MDM sustaining a pivotal role in the pathogenesis of immunological complications associated with the disease. [ABSTRACT FROM AUTHOR]

Published
2020
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193. A Customized Distraction Device for Alveolar Ridge Augmentation and Alignment of Ankylosed Teeth.

Author

Nocini, Pier Francesco, De Santis, Daniele, Ferrari, Francesca, and Bertele, Gian Paolo

Subjects
ALVEOLAR process, DENTAL implants, ANKYLOSIS, OSTEOTOMY, DENTAL screws, PROSTHETICS, DENTURES
Abstract

The purpose of this study was to develop an extraosseous, tooth-supported miniature intraoral device that could produce prosthetically driven bone distraction of small atrophic alveolar ridge segments. Extraosseous distraction requires that the distraction device be anchored to a dental implant previously placed into the ridge according to its anatomic axis. A distractor can also correct the position of implants placed in young patients before skeletal growth is completed. Similarly, it allows the alignment of ankylosed teeth not treatable by orthodontics. The device is made of (1) an engine consisting of an orthodontic micrometric screw; (2) a joint between the implant and the engine, ie, the ball attachment/o-ring system; and (3) an anchorage system to the oral cavity provided by an orthodontic appliance and a mini-implant for possible additional support. Surgery involves an osteotomy of the atrophic alveolar ridge segment, incorporating the implant, from the basal bone; afterward the device can be applied and distraction of the segment can be carried out. Distraction was successfully performed in 3 clinical cases: 2 bone-implant segments and 1 bone-ankylosed tooth segment. All cases were clinically uneventful. This mini-device for osteogenic distraction of small atrophic ridge segments can provide for accurate and precise ridge augmentation, as is required for ideal prosthetic rehabilitation. [ABSTRACT FROM AUTHOR]

Published
2004

194. Freelancer & Copyright in Italia

Author

Ferrari, Francesca

Subjects
Self employed persons -- Laws, regulations and rules -- Intellectual property, Intellectual property law -- Interpretation and construction, Government regulation, Business, international
Abstract

The introduction in Italy of the Jobs Act for self-employed workers (occurred with Law of May 22, 2017, no. 81, published in the Official Gazette on June 13 and enforced [...]

Published
2018

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