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154. Comparison of fludarabine/melphalan (FluMel) with fludarabine/melphalan/BCNU or thiotepa (FBM/FTM) in patients with AML in first complete remission undergoing allogeneic hematopoietic stem cell transplantation – a registry study on behalf of the EBMT Acute Leukemia Working Party.

Author

Duque-Afonso, Jesus, primary, Finke, Jürgen, additional, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Craddock, Charles, additional, Raj, Kavita, additional, Bloor, Adrian, additional, Nicholson, Emma, additional, Eder, Matthias, additional, Kim, Orchard, additional, Valerius, Thomas, additional, Snowden, John, additional, Tholouli, Eleni, additional, Crawley, Charles, additional, Collin, Matthew, additional, Wilson, Keith, additional, Gadisseur, Alain, additional, Protheroe, Rachel, additional, Wagner-Drouet, Eva, additional, Savani, Bipin, additional, Spyridonidis, Alexandros, additional, Ciceri, Fabio, additional, Nagler, Arnon, additional, and Mohty, Mohamad, additional

Published
2022
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157. Hematological Neoplasia

Author

Waesch, Ralph, Digel, Werner, Luebbert, Michael, Heining-Mikesch, Kristina, Waller, Cornelius, Lange, W., Heinz, Jürgen, Finke, Jürgen, Burger, Jan, Illerhaus, Gerald, Marks, Reinhard, Spyridonidis, Alexandros, Müller, Claudia I., Engelhardt, Monika, Stockschläder, Marcus, Berger, Dietmar P., editor, Engelhardt, Monika, editor, Henß, Hartmut, editor, and Mertelsmann, Roland, editor

Published
2008
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158. Medical Oncology

Author

Daskalakis, Michael, Henne, Karl, Henß, Hartmut, Martens, Uwe, Digel, Werner, Engelhardt, Rupert, Otto, Florian, Deschler, Barbara, Berger, Dietmar P., Allgaier, H.-P., Harder, Jan, Behringer, D., Waller, Cornelius, Trepel, Martin, Runnebaum, Ingo, Weissenberger, Christian, Spyridonidis, Alexandros, Schultze-Seemann, Wolfgang, Schrenk, K.G., Neumann, Hartmut, Reincke, Martin, Seufert, Jochen, Schwabe, Michael, Veelken, Hendrik, Marks, Reinhard, Finke, Jürgen, Heinz, Jürgen, Kleber, M., Berger, Dietmar P., editor, Engelhardt, Monika, editor, Henß, Hartmut, editor, and Mertelsmann, Roland, editor

Published
2008
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159. Hematology and Hemostasis

Author

Finke, Jürgen, Bertz, Hartmut, Kaskel, Anna-Katharina, Heinz, Jürgen, Thomas, A.K., Berger, Dietmar P., Engelhardt, Rupert, Schmah, Oliver, Berger, Dietmar P., editor, Engelhardt, Monika, editor, Henß, Hartmut, editor, and Mertelsmann, Roland, editor

Published
2008
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160. Special Diagnostics

Author

Kunzmann, Regina, Luebbert, Michael, Veelken, Hendrik, Scheele, Jürgen, Martens, Uwe, Engelhardt, Rupert, Fetscher, Sebastian, Otto, Florian, Behringer, D., Jüttner, Eva, Burger, Jan, Burger, Meike, Grüllich, Carsten, Houet, Leonora, Finke, Jürgen, Berger, Dietmar P., editor, Engelhardt, Monika, editor, Henß, Hartmut, editor, and Mertelsmann, Roland, editor

Published
2008
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161. Particular Treatment Procedures

Author

Deschler, Barbara, Waller, Cornelius, Engelhardt, Monika, Müller, Antonia, Luebbert, Michael, Finke, Jürgen, Bertz, Hartmut, Illerhaus, Gerald, Kaskel, Anna-Katharina, Mackensen, A., Veelken, Hendrik, Rosenthal, F. M., Müller, Claudia I., Scheele, Jürgen, Martens, Uwe, Berger, Dietmar P., editor, Engelhardt, Monika, editor, Henß, Hartmut, editor, and Mertelsmann, Roland, editor

Published
2008
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162. Standardized Treatment Protocols

Author

Behringer, D., Berger, Dietmar P., Digel, Werner, Engelhardt, Monika, Finke, Jürgen, Bertz, Hartmut, Henß, Hartmut, Luebbert, Michael, Mertelsmann, Roland, Waller, Cornelius, Berger, Dietmar P., editor, Engelhardt, Monika, editor, Henß, Hartmut, editor, and Mertelsmann, Roland, editor

Published
2008
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163. Unmanipulated haploidentical in comparison with matched unrelated donor stem cell transplantation in patients 60 years and older with acute myeloid leukemia: a comparative study on behalf of the ALWP of the EBMT

Author

Santoro, Nicole, Labopin, Myriam, Giannotti, Federica, Ehninger, Gerard, Niederwieser, Dietger, Brecht, Arne, Stelljes, Matthias, Kröger, Nicolaus, Einsele, Herman, Eder, Matthias, Hallek, Michael, Glass, Bertram, Finke, Jürgen, Ciceri, Fabio, Mohty, Mohamad, Ruggeri, Annalisa, and Nagler, Arnon

Published
2018
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164. CMV serostatus still has an important prognostic impact in de novo acute leukemia patients after allogeneic stem cell transplantation: a report from the Acute Leukemia Working Party of EBMT

Author

Schmidt-Hieber, Martin, Labopin, Myriam, Beelen, Dietrich, Volin, Liisa, Ehninger, Gerhard, Finke, Jürgen, Socié, Gerard, Schwerdtfeger, Rainer, Kröger, Nicolaus, Ganser, Arnold, Niederwieser, Dietger, Polge, Emmanuelle, Blau, Igor W., and Mohty, Mohamad

Published
2013
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168. Treosulfan compared with reduced‐intensity busulfan improves allogeneic hematopoietic cell transplantation outcomes of older acute myeloid leukemia and myelodysplastic syndrome patients: Final analysis of a prospective randomized trial

Author

Beelen, Dietrich W., primary, Stelljes, Matthias, additional, Reményi, Péter, additional, Wagner‐Drouet, Eva‐Maria, additional, Dreger, Peter, additional, Bethge, Wolfgang, additional, Ciceri, Fabio, additional, Stölzel, Friedrich, additional, Junghanß, Christian, additional, Labussiere‐Wallet, Hélène, additional, Schaefer‐Eckart, Kerstin, additional, Grigoleit, Goetz U., additional, Scheid, Christof, additional, Patriarca, Francesca, additional, Rambaldi, Alessandro, additional, Niederwieser, Dietger, additional, Hilgendorf, Inken, additional, Russo, Domenico, additional, Socié, Gérard, additional, Holler, Ernst, additional, Glass, Bertram, additional, Casper, Jochen, additional, Wulf, Gerald, additional, Basara, Nadezda, additional, Bieniaszewska, Maria, additional, Stuhler, Gernot, additional, Verbeek, Mareike, additional, La Rocca, Ursula, additional, Finke, Jürgen, additional, Benedetti, Fabio, additional, Pichlmeier, Uwe, additional, Klein, Anja, additional, Baumgart, Joachim, additional, and Markiewicz, Miroslaw, additional

Published
2022
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169. Longitudinal Outcome over Two Decades of Unrelated Allogeneic Stem Cell Transplantation for Relapsed/Refractory Acute Myeloid Leukemia: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, additional, Galimard, Jacques-Emmanuel, additional, Labopin, Myriam, additional, Bornhäuser, Martin, additional, Stelljes, Matthias, additional, Finke, Jürgen, additional, Ganser, Arnold, additional, Einsele, Herman, additional, Kröger, Nicolaus, additional, Brecht, Arne, additional, Bethge, Wolfgang, additional, Edinger, Matthias, additional, Kulagin, Aleksandr, additional, Passweg, Jakob, additional, Blau, Igor Wolfgang, additional, Elmaagacli, Ahmet, additional, Schäfer-Eckart, Kerstin, additional, Platzbecker, Uwe, additional, Schroeder, Thomas, additional, Bunjes, Donald, additional, Tischer, Johanna, additional, Martin, Sonja, additional, Spyridonidis, Alexandros, additional, Giebel, Sebastian, additional, Savani, Bipin, additional, and Mohty, Mohamad, additional

Published
2022
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170. Favourable outcomes of double‐hit/double‐expressor lymphoma and high‐grade B‐cell lymphoma, not otherwise specified after early dose‐intensive treatment and up‐front autologous stem cell transplantation: a single‐centre retrospective experience

Author

Strüßmann, Tim, primary, Glatzki, Franziska, additional, Engelhardt, Monika, additional, Mertelsmann, Roland, additional, Duyster, Justus, additional, Finke, Jürgen, additional, and Marks, Reinhard, additional

Published
2022
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172. Supplement to: Antilymphocyte globulin for prevention of chronic graft-versus-host disease.

Author

Kröger, Nicolaus, Solano, Carlos, Wolschke, Christine, Bandini, Giuseppe, Patriarca, Francesca, Pini, Massimo, Nagler, Arnon, Selleri, Carmine, Risitano, Antonio, Messina, Giuseppe, Bethge, Wolfgang, de Oteiza, Jaime Pérez, Duarte, Rafael, Carella, Angelo Michele, Cimminiello, Michele, Guidi, Stefano, Finke, Jürgen, Mordini, Nicola, Ferra, Christelle, Sierra, Jorge, Russo, Domenico, Petrini, Mario, Milone, Giuseppe, Benedetti, Fabio, Heinzelmann, Marion, Pastore, Domenico, Jurado, Manuel, Terruzzi, Elisabetta, Narni, Franco, Völp, Andreas, Ayuk, Francis, Ruutu, Tapani, and Bonifazi, Francesca

Published
2016

173. Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

Author

Dreger, Peter, Schweizerische Gesellschaft Für Hämatologie, Greinix, Hildegard, Schweizerische Gesellschaft Für Medizinische Onkologie, Luft, Thomas, Scheid, Christoph, Zeiser, Robert, Österreichische Gesellschaft Für Hämatologie & Medizinische Onkologie, Finke, Jürgen, Mielke, Stephan, Holler, Ernst, Wolff, Daniel, Deutsche Arbeitsgemeinschaft Für Knochenmark- Und Blutstammzelltransplantation, and Deutsche Gesellschaft Für Hämatologie Und Medizinische Onkologie

Subjects
Medizin und Gesundheit
Published
2022
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176. Prognostic Factors Affecting Outcome after Allogeneic Transplantation for Hematological Malignancies from Unrelated Donors: Results from a Randomized Trial

Author

Finke, Jürgen, Schmoor, Claudia, Bethge, Wolfgang A., Ottinger, Hellmut D., Stelljes, Matthias, Zander, Axel R., Volin, Liisa, Heim, Dominik A., Schwerdtfeger, Rainer, Kolbe, Karin, Mayer, Jiri, Maertens, Johan A., Linkesch, Werner, Holler, Ernst, Koza, Vladimir, Bornhäuser, Martin, Einsele, Hermann, Bertz, Hartmut, Grishina, Olga, and Socié, Gérard

Published
2012
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177. Circulating Tumor DNA Profiling for Detection, Risk Stratification, and Classification of Brain Lymphomas.

Author

Mutter, Jurik A., Alig, Stefan K., Esfahani, Mohammad S., Lauer, Eliza M., Mitschke, Jan, Kurtz, David M., Kühn, Julia, Bleul, Sabine, Olsen, Mari, Liu, Chih Long, Jin, Michael C., Macaulay, Charles W., Neidert, Nicolas, Volk, Timo, Eisenblaetter, Michel, Rauer, Sebastian, Heiland, Dieter H., Finke, Jürgen, Duyster, Justus, and Wehrle, Julius

Published
2023
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179. Allogeneic Hematopoietic Cell Transplantation in Patients Age 60-70 Years with De Novo High-Risk Myelodysplastic Syndrome or Secondary Acute Myelogenous Leukemia: Comparison with Patients Lacking Donors Who Received Azacitidine

Author

Platzbecker, Uwe, Schetelig, Johannes, Finke, Jürgen, Trenschel, Rudolf, Scott, Bart L., Kobbe, Guido, Schaefer-Eckart, Kerstin, Bornhäuser, Martin, Itzykson, Raphael, Germing, Ulrich, Beelen, Dietrich, Ehninger, Gerhard, Fenaux, Pierre, Deeg, H. Joachim, and Adès, Lionel

Published
2012
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182. Classifying Cytogenetics in Patients with Acute Myelogenous Leukemia in Complete Remission Undergoing Allogeneic Transplantation: A Center for International Blood and Marrow Transplant Research Study

Author

Armand, Philippe, Kim, Haesook T., Zhang, Mei-Jie, Perez, Waleska S., Dal Cin, Paola S., Klumpp, Thomas R., Waller, Edmund K., Litzow, Mark R., Liesveld, Jane L., Lazarus, Hillard M., Artz, Andrew S., Gupta, Vikas, Savani, Bipin N., McCarthy, Philip L., Cahn, Jean-Yves, Schouten, Harry C., Finke, Jürgen, Ball, Edward D., Aljurf, Mahmoud D., Cutler, Corey S., Rowe, Jacob M., Antin, Joseph H., Isola, Luis M., Di Bartolomeo, Paolo, Camitta, Bruce M., Miller, Alan M., Cairo, Mitchell S., Stockerl-Goldstein, Keith, Sierra, Jorge, Savoie, M. Lynn, Halter, Joerg, Stiff, Patrick J., Nabhan, Chadi, Jakubowski, Ann A., Bunjes, Donald W., Petersdorf, Effie W., Devine, Steven M., Maziarz, Richard T., Bornhauser, Martin, Lewis, Victor A., Marks, David I., Bredeson, Christopher N., Soiffer, Robert J., and Weisdorf, Daniel J.

Published
2012
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184. Favourable Outcome after Treosulfan Based Conditioning of Patients Receiving an Allogeneic Hematopoietic Cell Transplantation (AlloHCT) for the Treatment of a Myelodysplastic Syndrome (MDS)

Author

Stelljes, Matthias, primary, Trenschel, Rudolf, additional, Beelen, Dietrich Wilhelm, additional, Markiewicz, Miroslaw, additional, Wagner, Eva Maria, additional, Bethge, Wolfgang, additional, Remenyi, Peter, additional, Niederwieser, Dietger, additional, Grigoleit, Goetz, additional, Schaefer-Eckart, Kerstin, additional, Stölzel, Friedrich, additional, Ciceri, Fabio, additional, Dreger, Peter, additional, Junghanß, Christian, additional, Holler, Ernst, additional, Rambaldi, Alessandro, additional, Russo, Domenico, additional, Verbeek, Mareike, additional, Casper, Jochen, additional, Patriarca, Francesca, additional, Bieniaszewska, Maria, additional, Glass, Bertram, additional, Scheid, Christoph, additional, Basara, Nadezda, additional, Finke, Jürgen, additional, Hilgendorf, Inken, additional, Labussière-Wallet, Hélène, additional, Stuhler, Gernot, additional, and Schroeder, Thomas, additional

Published
2022
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185. Evaluation of Trends in Outcome over 2 Decades of Patients with Relapsed/Refractory Acute Myelogenous Leukemia Undergoing Allogeneic Stem Cell Transplantation from Unrelated Donors: An ALWP/EBMT Analysis

Author

Nagler, Arnon, primary, Ngoya, Maud, additional, Labopin, Myriam, additional, Bornhauser, Martin, additional, Stelljes, Matthias, additional, Finke, Jürgen, additional, Ganser, Arnold, additional, Einsele, Hermann, additional, Kroger, Nicolaus, additional, Brecht, Arne, additional, Bethge, Wolfgang, additional, Edinger, Matthias, additional, Kulagin, Aleksandr, additional, Passweg, Jakob, additional, Elmaagacli, Ahmet, additional, Schafer-Eckart, K., additional, Platzbecker, Uwe, additional, Schroeder, Thomas, additional, Bunjes, Donald, additional, Tischer, Johanna, additional, Martin, Sonja, additional, Spyridonidis, Alexandros, additional, Giebel, Sebastian, additional, Savani, Bipin, additional, and Mohty, Mohamad, additional

Published
2022
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187. Chronic graft-versus-host disease: long-term results from a randomized trial on graft-versus-host disease prophylaxis with or without anti–T-cell globulin ATG-Fresenius

Author

Socié, Gérard, Schmoor, Claudia, Bethge, Wolfgang A., Ottinger, Hellmut D., Stelljes, Matthias, Zander, Axel R., Volin, Liisa, Ruutu, Tapani, Heim, Dominik A., Schwerdtfeger, Rainer, Kolbe, Karin, Mayer, Jiri, Maertens, Johan A., Linkesch, Werner, Holler, Ernst, Koza, Vladimir, Bornhäuser, Martin, Einsele, Hermann, Kolb, Hans-Jochem, Bertz, Hartmut, Egger, Matthias, Grishina, Olga, and Finke, Jürgen

Published
2011
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191. Profiling of Circulating Tumor DNA for Noninvasive Disease Detection, Risk Stratification, and MRD Monitoring in Patients with CNS Lymphoma

Author

Mutter, Jurik Andreas, primary, Alig, Stefan, additional, Lauer, Eliza Maria, additional, Esfahani, Mohammad Shahrokh, additional, Mitschke, Jan, additional, Kurtz, David M., additional, Kühn, Julia, additional, Bleul, Sabine, additional, Olsen, Mari, additional, Liu, Chih Long, additional, Jin, Michael C., additional, Macaulay, Charles, additional, Neidert, Nicolas Noel, additional, Volk, Timo, additional, Rauer, Sebastian, additional, Heiland, Dieter Henrik, additional, Finke, Jürgen, additional, Duyster, Justus, additional, Wehrle, Julius, additional, Prinz, Marco, additional, Illerhaus, Gerald, additional, Reinacher, Peter C., additional, Schorb, Elisabeth, additional, Diehn, Maximilian, additional, Alizadeh, Ash A., additional, and Scherer, Florian, additional

Published
2021
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192. Allogeneic Stem Cell Transplantation in Patients Aged ≥70 Years: Epidemiology, Outcomes, and Risk Factors Based on the German Registry for Stem Cell Transplantation (DRST)

Author

Weller, Jan Frederic, primary, Kaufmann, Louisa, additional, Lengerke, Claudia, additional, Finke, Jürgen, additional, Schetelig, Johannes, additional, Platzbecker, Uwe, additional, Einsele, Hermann, additional, Beelen, Dietrich W., additional, Faul, Christoph, additional, Stelljes, Matthias, additional, Dreger, Peter, additional, Blau, Igor Wolfgang, additional, Wulf, Gerald, additional, Tischer, Johanna, additional, Scheid, Christof, additional, Elmaagacli, Ahmet, additional, Neidlinger, Helga, additional, Frank, Sandra, additional, Bornhäuser, Martin, additional, Bethge, Wolfgang A, additional, Fleischhauer, Katharina, additional, Kröger, Nicolaus, additional, and Christopeit, Maximilian, additional

Published
2021
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193. Allogeneic Hematopoietic Cell Transplantation for Acute Myeloid Leukemia with Hyperdiploid Complex Karyotype: A Study from the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Author

Poiré, Xavier, primary, Labopin, Myriam, additional, Polge, Emmanuelle, additional, Ganser, Arnold, additional, Socie, Gerard, additional, Gedde-Dahl, Tobias, additional, Forcade, Edouard, additional, Finke, Jürgen, additional, Chalandon, Yves, additional, Bulabois, Claude-Eric, additional, Yakoub-Agha, Ibrahim, additional, Aljurf, Mahmoud, additional, Kröger, Nicolaus, additional, Blau, Igor Wolfgang, additional, Nagler, Arnon, additional, Esteve, Jordi, additional, and Mohty, Mohamad, additional

Published
2021
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194. Antilymphocyte Globulin for Prevention of Chronic Graft-versus-Host Disease

Author

Kröger, Nicolaus, Solano, Carlos, Wolschke, Christine, Bandini, Giuseppe, Patriarca, Francesca, Pini, Massimo, Nagler, Arnon, Selleri, Carmine, Risitano, Antonio, Messina, Giuseppe, Bethge, Wolfgang, Pérez de Oteiza, Jaime, Duarte, Rafael, Carella, Angelo Michele, Cimminiello, Michele, Guidi, Stefano, Finke, Jürgen, Mordini, Nicola, Ferra, Christelle, Sierra, Jorge, Russo, Domenico, Petrini, Mario, Milone, Giuseppe, Benedetti, Fabio, Heinzelmann, Marion, Pastore, Domenico, Jurado, Manuel, Terruzzi, Elisabetta, Narni, Franco, Völp, Andreas, Ayuk, Francis, Ruutu, Tapani, and Bonifazi, Francesca

Published
2016
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198. Allogeneic hematopoietic cell transplantation in older myelofibrosis patients: A study of the chronic malignancies working party of EBMT and the Spanish Myelofibrosis Registry

Author

Hernández‐Boluda, Juan‐Carlos, primary, Pereira, Arturo, additional, Kröger, Nicolaus, additional, Cornelissen, Jan J., additional, Finke, Jürgen, additional, Beelen, Dietrich, additional, de Witte, Moniek, additional, Wilson, Keith, additional, Platzbecker, Uwe, additional, Sengeloev, Henrik, additional, Blaise, Didier, additional, Einsele, Hermann, additional, Sockel, Katja, additional, Krüger, William, additional, Lenhoff, Stig, additional, Salaroli, Adriano, additional, Martin, Hans, additional, García‐Gutiérrez, Valentín, additional, Pavone, Vicenzo, additional, Alvarez‐Larrán, Alberto, additional, Raya, José‐María, additional, Zinger, Nienke, additional, Gras, Luuk, additional, Hayden, Patrick, additional, Czerw, Tomasz, additional, P. McLornan, Donal, additional, and Yakoub‐Agha, Ibrahim, additional

Published
2021
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199. How Much Have Post-Transplant Outcomes Improved Since 2000 for Older Patients with Acute Myeloid Leukemia? a Study from the EBMT Acute Leukemia Working Party

Author

Bazarbachi, Ali, Labopin, Myriam, Moukalled, Nour, Kröger, Nicolaus, Rautenberg, Christina, Schetelig, Johannes, Finke, Jürgen, Wolfgang Blau, Igor, Blaise, Didier, Stelljes, Matthias, Eder, Matthias, Platzbecker, Uwe, Dreger, Peter, Bethge, Wolfgang Andreas, Tischer, Johanna, Burns, David, Sengeloev, Henrik, Brissot, Eolia, Giebel, Sebastian, Nagler, Arnon, Ciceri, Fabio, and Mohty, Mohamad

Published
2023
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200. Comparison of Dynamic International Prognostic Scoring System and MYelofibrosis SECondary to PV and ET Prognostic Model for Prediction of Outcome in Polycythemia Vera and Essential Thrombocythemia Myelofibrosis after Allogeneic Stem Cell Transplantation

Author

Gagelmann, Nico, Eikema, Diderik-Jan, de Wreede, Liesbeth C, Koster, Linda, Wolschke, Christine, Arnold, Renate, Kanz, Lothar, McQuaker, Grant, Marchand, Tony, Socié, Gerard, Bourhis, Jean Henri, Mohty, Mohamad, Cornelissen, Jan J, Chevallier, Patrice, Bernasconi, Paolo, Stelljes, Matthias, Rohrlich, Pierre-Simon, Fanin, Renato, Finke, Jürgen, Maertens, Johan, Blaise, Didier, Itälä-Remes, Maija, Labussière-Wallet, Hélène, Robin, Marie, McLornan, Donal, Chalandon, Yves, Yakoub-Agha, Ibrahim, Kröger, Nicolaus, CMWP of the European Society for Blood and Marrow Transplantation, Hematology, and Medical Oncology

Subjects
Adult, medicine.medical_specialty, Essential thrombocythemia, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Polycythemia vera, Internal medicine, Humans, Transplantation, Homologous, Medicine, Allogeneic stem cell transplantation, Secondary myelofibrosis, Hematology, Transplantation, Myelofibrosis, Polycythemia Vera, Survival analysis, Aged, ddc:616, Framingham Risk Score, business.industry, Hematopoietic Stem Cell Transplantation, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Treatment Outcome, Primary Myelofibrosis, International Prognostic Scoring System, 030220 oncology & carcinogenesis, Cohort, business, Thrombocythemia, Essential, 030215 immunology
Abstract

We aimed to validate the MYelofibrosis SECondary to PV and ET prognostic model (MYSEC-PM) in 159 patients with myelofibrosis secondary to polycythemia vera (PV) and essential thrombocythemia (ET) from the European Society for Blood and Marrow Transplantation registry undergoing transplantation from matched siblings or unrelated donors. Furthermore, we aimed to test its prognostic performance in comparison with the Dynamic International Prognostic Scoring System (DIPSS). Score performance was analyzed using the concordance index (C): the probability that a patient who experienced an event had a higher risk score than a patient who did not (C > .5 suggesting predictive ability). Median follow-up of the total cohort was 41 months (range, 34 to 54), 45 months in post-PV and 38 months in post-ET myelofibrosis. Survival at 1, 2, and 4 years was 70% (95% CI, 63% to 77%), 61% (95% CI, 53% to 69%), and 52% (95% CI, 43% to 61%) for the total cohort; 70% (95% CI, 59% to 80%), 61% (95% CI, 49% to 73%), and 51% (95% CI, 38% to 64%) for post-PV; and 71% (95% CI, 61% to 81%), 61% (95% CI, 50% to 72%), and 54% (95% CI, 42% to 66%) for post-ET myelofibrosis (P = .78). Overall, the DIPSS was not significantly predictive of outcome (P = .28). With respect to the MYSEC-PM, overall survival at 4 years was 69% for the low-risk, 55% for the intermediate 1-risk, 47% for the intermediate 2-risk, and 22% (0% to 45%) for the high-risk groups. The prognostic model was predictive of survival overall (P = .05), whereas groups with intermediate 2 and high risk showed no significant difference (P = .44). Assessment of prognostic utility yielded a C-index of .575 (95% CI, .502 to .648) for the DIPSS, whereas assessment of the MYSEC-PM resulted in a C-statistics of .636 (95% CI, .563 to .708), indicating improvement in prediction of post-transplant survival using the new MYSEC-PM. In addition, transplantations from an unrelated donor in comparison with an HLA-identical sibling showed worse outcome (P = .04), and transplant recipients seropositive for cytomegalovirus in comparison with seronegative recipients (P = .01) showed worse survival. In conclusion, incorporating transplant-specific and clinical and mutational information together with the MYSEC-PM may enhance risk stratification. ispartof: Biol Blood Marrow Transplant vol:25 issue:6 pages:e204-e208 ispartof: location:United States status: published

Published
2019

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