Search

Vorgeschichte: Bei einem 38-jährigen Patienten wurde vor 2,5 Jahren bei damals seit drei Monaten bestehenden Arthritiden im Bereich der Hand-, Finger- und Kniegelenke und entzündlichem Kreuzschmerz mit damals MR-tomographischem Nachweis einer beidseitigen Sakroiliitis die Diagnose einer HLA[zum vollständigen Text gelangen Sie über die oben angegebene URL], 45. Kongress der Deutschen Gesellschaft für Rheumatologie (DGRh), 31. Jahrestagung der Deutschen Gesellschaft für Orthopädische Rheumatologie (DGORh), 27. Jahrestagung der Gesellschaft für Kinder- und Jugendrheumatologie (GKJR)

Table S1. Primer sequences for PCR of the genes BRAF (exon 15), NRAS (exon 2), and NRAS (exon 3). Table S2. Probes for pyrosequencing of the genes BRAF (exon 15), NRAS (exon 2), and NRAS (exon 3). (DOCX 14Â kb)

Kaplan-Meier estimates for overall survival according to disease stage. Patients were staged according to the current staging system of AJCC from 2009 at primary diagnosis to internally validate the dataset. The survival curves showed a clear and significant stratification from stage I to stage IV. The indicated p-value was calculated with the log-rank test. (PDF 287Â kb)

Time to event analyses after patients with other malignancies than melanoma were excluded (n = 179). The times to loco-regional relapse and metastatic disease were assessed with the cumulative incidence function. Indicated p-values were calculated with the Gray’s test. Overall and relative survival were computed with the Kaplan-Meier and Ederer-II method, respectively. The p-value for overall survival was calculated with the log-rank test. (PDF 358 kb)

Introduction. At first sight, chronic recurrent multifocal osteomyelitis (CRMO) and Schnitzler's disease are diagnoses of exclusion and can be similar in their manifestation. Methods. In this paper we present the reevaluation of the 13-year-old diagnosis of chronic recurrent osteomyelitis of a 58-year-old man with chronic ostealgia, night sweat, and pruritic urticarial lesions on the extremities and trunk. For further examination, we performed blood analysis, bone and skin biopsies, CT scans, and magnetic resonance imaging. Results. Laboratory findings showed increased inflammation parameters. Magnetic resonance imaging (MRI) revealed a diffuse bone marrow infiltration. A bone and skin biopsy showed a sclerotic bone marrow involvement and a superficial dermal and perivascular infiltrate of neutrophils. Based on these findings, the diagnosis of Schnitzler’s disease was made. Conclusion. Here, we want to present Schnitzler's disease as an important differential diagnosis to CRMO in adults presenting with signs suggestive of CRMO.

A 35-year-old woman who developed whitish macules on trunk and limbs at 12 years of age and observed a remarkable increase of the hypopigmentated lesions after her pregnancies at ages 29 and 32 years. Because of the highly characteristic clinical aspect and the light- and electron-microscopic histopathologic findings, we diagnosed progressive macular hypomelanosis (PMH). It is a nonscaly disorder with hypopigmented macules mainly on the trunk and is more often seen in young women. In contrast to some authors assuming the presence of Propionibacterium spp. as a matter of principle in PMH, we report a case with no evidence for Propionibacterium spp.