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1,151 results on '"Flint M"'

158. A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease: No Evidence of Benefit

Author

Beal, Flint M., Oakes, David, Shoulson, Ira, Henchcliffe, Claire, Galpern, Wendy R., Haas, Richard, Juncos, Jorge L., Nutt, John G., Voss, Tiffini Smith, Ravina, Bernard, Shults, Clifford M., Helles, Karen, Snively, Victoria, Lew, Mark F., Griebner, Brian, Watts, Arthur, Gao, Shan, Pourcher, Emmanuelle, Bond, Louisette, Kompoliti, Katie, Agarwal, Pinky, Sia, Cherissa, Jog, Mandar, Cole, Linda, Sultana, Munira, Kurlan, Roger, Richard, Irene, Deeley, Cheryl, Waters, Cheryl H., Figueroa, Angel, Arkun, Ani, Brodsky, Matthew, Ondo, William G., Hunter, Christine B., Jimenez-Shahed, Joohi, Palao, Alicia, Miyasaki, Janis M., So, Julie, Tetrud, James, Reys, Liza, Smith, Katharine, Singer, Carlos, Blenke, Anita, Russell, David S., Cotto, Candace, Friedman, Joseph H., Lannon, Margaret, Zhang, Lin, Drasby, Edward, Kumar, Rajeev, Subramanian, Thyagarajan, Ford, Donna Stuppy, Grimes, David A., Cote, Diane, Conway, Jennifer, Siderowf, Andrew D., Evatt, Marian Leslie, Sommerfeld, Barbara, Lieberman, Abraham N., Okun, Michael S., Rodriguez, Ramon L., Merritt, Stacy, Swartz, Camille Louise, Martin, Wayne W. R., King, Pamela, Stover, Natividad, Guthrie, Stephanie, Watts, Ray L., Ahmed, Anwar, Fernandez, Hubert H., Winters, Adrienna, Mari, Zoltan, Dawson, Ted M., Dunlop, Becky, Feigin, Andrew S., Shannon, Barbara, Nirenberg, Melissa Jill, Ogg, Mattson, Ellias, Samuel A., Thomas, Cathi-Ann, Frei, Karen, Bodis-Wollner, Ivan, Glazman, Sofya, Mayer, Thomas, Hauser, Robert A., Pahwa, Rajesh, Langhammer, April, Ranawaya, Ranjit, Derwent, Lorelei, Sethi, Kapil D., Farrow, Buff, Prakash, Rajan, Litvan, Irene, Robinson, Annette, Sahay, Alok, Gartner, Maureen, Hinson, Vanessa K., Markind, Samuel, Pelikan, Melisa, Perlmutter, Joel S., Hartlein, Johanna, Molho, Eric, Evans, Sharon, Adler, Charles H., Duffy, Amy, Lind, Marlene, Elmer, Lawrence, Davis, Kathy, Spears, Julia, Wilson, Stephanie, Leehey, Maureen A., Hermanowicz, Neal, Niswonger, Shari, Shill, Holly A., Obradov, Sanja, Rajput, Alex, Cowper, Marilyn, Lessig, Stephanie, Song, David, Fontaine, Deborah, Zadikoff, Cindy, Williams, Karen, Blindauer, Karen A., Bergholte, Jo, Propsom, Clara Schindler, Stacy, Mark A., Field, Joanne, Mihaila, Dragos, Chilton, Mark, Uc, Ergun Y., Sieren, Jeri, Simon, David K., Kraics, Lauren, Silver, Althea, Boyd, James T., Hamill, Robert W., Ingvoldstad, Christopher, Young, Jennifer, Thomas, Karen, Kostyk, Sandra K., Wojcieszek, Joanne, Pfeiffer, Ronald F., Panisset, Michel, Beland, Monica, Reich, Stephen G., Cines, Michelle, Zappala, Nancy, Rivest, Jean, Zweig, Richard, Lumina, Pepper L., Hilliard, Colette Lynn, Grill, Stephen, Kellermann, Marye, Tuite, Paul, Rolandelli, Susan, Kang, Un Jung, Young, Joan, Rao, Jayaraman, Cook, Maureen M., Severt, Lawrence, and Boyar, Karyn

Published
2014
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160. Inosine to Increase Serum and Cerebrospinal Fluid Urate in Parkinson Disease: A Randomized Clinical Trial

Author

Schwarzschild, Michael A., Ascherio, Alberto, Beal, Flint M., Cudkowicz, Merit E., Curhan, Gary C., Hare, Joshua M., Hooper, Craig D., Kieburtz, Karl D., Macklin, Eric A., Oakes, David, Rudolph, Alice, Shoulson, Ira, Tennis, Marsha K., Espay, Alberto J., Gartner, Maureen, Hung, Albert, Bwala, Grace, Lenehan, Richard, Encarnacion, Elmyra, Ainslie, Melissa, Castillo, Richard, Togasaki, Daniel, Barles, Gina, Friedman, Joseph H., Niles, Lisa, Carter, Julie H., Murray, Megan, Goetz, Christopher G., Jaglin, Jeana, Ahmed, Anwar, Russell, David S., Cotto, Candace, Goudreau, John L., Russell, Doozie, Parashos, Sotirios Andreas, Ede, Patricia, Saint-Hilaire, Marie H., Thomas, Cathi-Ann, James, Raymond, Stacy, Mark A., Johnson, Julia, Gauger, Lisa, de Marcaida, Antonelle J., Thurlow, Sheila, Isaacson, Stuart H., Carvajal, Lisbeth, Rao, Jayaraman, Cook, Maureen, Hope-Porche, Charlise, McClurg, Lauren, Grasso, Daniela L., Logan, Robert, Orme, Constance, Ross, Tori, Brocht, Alicia F. D., Constantinescu, Radu, Sharma, Saloni, Venuto, Charles, Weber, Joseph, and Eaton, Ken

Published
2014
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164. Training early psychosis community clinicians in CBT for psychosis: Implementation and feasibility

Author

Christopher L. Smith, Kate V. Hardy, Al Gilbert, Rachel Loewy, Flint M. Espil, Zhen Zhao, Adriana Furuzawa, Melanie Lean, and Julia Godzikovskaya

Subjects
medicine.medical_specialty, Psychosis, medicine.medical_treatment, education, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Competence (human resources), Referral and Consultation, Biological Psychiatry, Training period, Cognitive Behavioral Therapy, business.industry, Early psychosis, Cognition, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Psychotic Disorders, Family medicine, Evidence-Based Practice, Cognitive therapy, Feasibility Studies, Pshychiatric Mental Health, Training program, business, 030217 neurology & neurosurgery
Abstract

Objective Cognitive behavioural therapy (CBT) has demonstrated efficacy for treating of psychotic symptoms and is recommended as an evidence-based practice (EBP) in early psychosis services. Despite this recommendation, there is limited information about the feasibility of training community clinicians, working in an early psychosis service, to competence in the delivery of this intervention. Method Fifty clinicians working in an early psychosis service across five programs in Northern California were trained in CBT for psychosis (CBTp) between 2010 and 2014. Following the training, clinicians attended weekly group consultation and submitted taped sessions for review. Tapes were rated for competency using the Cognitive Therapy Scale-Revised (CTS-R). Clinicians who achieved competence were engaged in a train-the-trainer model to support ongoing sustainability of the training program. Results Data from 40 clinicians were reviewed for achievement of competence. Over the training period 18 clinicians achieved competence while 20 clinicians left the service before achieving competence and 12 were still in the process of achieving competence at the point of data analysis. It took on average 54 weeks (range 17-130 weeks) and an average of six tape reviews (range 3-18) to train clinicians to competency. Conclusions Community clinicians working in an early psychosis program can be trained to competence in CBTp following an initial didactic period and ongoing weekly group consultation, although staff turnover hindered implementation. Challenges and opportunities for future implementation in community sites are presented in the context of further expansion of early psychosis services in the United States.

Published
2020

165. Glycemic Variability in Diabetes Increases the Severity of Influenza

Author

Marshall RJ, Armart P, Hulme KD, Chew KY, Brown AC, Hansbro PM, Bloxham CJ, Flint M, Ronacher K, Bielefeldt-Ohmann H, Gallo LA, and Short KR

Subjects
0605 Microbiology
Abstract

People with diabetes are two times more likely to die from influenza than people with no underlying medical condition. The mechanisms underlying this susceptibility are poorly understood. In healthy individuals, small and short-lived postprandial peaks in blood glucose levels occur. In diabetes mellitus, these fluctuations become greater and more frequent. This glycemic variability is associated with oxidative stress and hyperinflammation. However, the contribution of glycemic variability to the pathogenesis of influenza A virus (IAV) has not been explored. Here, we used an in vitro model of the pulmonary epithelial-endothelial barrier and novel murine models to investigate the role of glycemic variability in influenza severity. In vitro, a history of glycemic variability significantly increased influenza-driven cell death and destruction of the epithelial-endothelial barrier. In vivo, influenza virus-infected mice with a history of glycemic variability lost significantly more body weight than mice with constant blood glucose levels. This increased disease severity was associated with markers of oxidative stress and hyperinflammation both in vitro and in vivo Together, these results provide the first indication that glycemic variability may help drive the increased risk of severe influenza in people with diabetes mellitus.IMPORTANCE Every winter, people with diabetes are at increased risk of severe influenza. At present, the mechanisms that cause this increased susceptibility are unclear. Here, we show that the fluctuations in blood glucose levels common in people with diabetes are associated with severe influenza. These data suggest that glycemic stability could become a greater clinical priority for patients with diabetes during outbreaks of influenza.

Published
2020

168. A multicentre cross-sectional descriptive study evaluating the cardiovascular risk profile of preoperatively identified patients with hypertension

Author

Govender, S, primary, Pfister, C, additional, Rayner, B, additional, Dyer, R, additional, Flint, M, additional, Roodt, F, additional, Davids, J, additional, Nejthardt, M B, additional, Swanevelder, J L, additional, Chiu, E, additional, Cloete, E, additional, Koller, V, additional, Pretorius, T, additional, Fullerton, Z, additional, Roos, J, additional, Van Zyl, R, additional, and Biccard, B M, additional

Published
2020
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171. Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT-TRD) induces rapid remission from treatment-resistant depression in a double-blinded, randomized, and controlled trial.

Author

Phillips, Angela L., primary, Cole, Eleanor J., additional, Bentzley, Brandon S., additional, Stimpson, Katy H., additional, Nejad, Romina, additional, Tischler, Claudia, additional, Barmak, Fahim, additional, Veerapal, Clive, additional, Khan, Naushaba, additional, Cherian, Kirsten, additional, Felber, Emily, additional, Brown, Randi, additional, Choi, Elizabeth, additional, Bishop, James, additional, Azeez, Ph.D; Azeezat, additional, Coetzee, John, additional, Rapier, Rachel, additional, Odenwald, Nicole, additional, Carreon, David, additional, Hawkins, Jessica, additional, Chang, Maureen, additional, Espil, Flint M., additional, Schatzberg, Alan F, additional, Sudheimer, Keith D, additional, and Williams, Nolan R, additional

Published
2020
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180. Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT-TRD) induces rapid remission from treatment-resistant depression in a double-blinded, randomized, and controlled trial

Author

Naushaba Khan, David Carreon, Clive Veerapal, Romina Nejad, Claudia Tischler, Jessica Hawkins, Keith Sudheimer, Alan F. Schatzberg, Nolan R. Williams, Emily Felber, John P. Coetzee, Kirsten Cherian, Maureen Chang, Azeezat Azeez, Flint M. Espil, Katy H. Stimpson, Nicole Odenwald, Fahim Barmak, Angela Phillips, Randi Brown, Elizabeth Choi, Brandon S. Bentzley, James Bishop, E. Cole, and Rachel Rapier

Subjects
business.industry, Double blinded, General Neuroscience, Biophysics, medicine.disease, Neuromodulation (medicine), law.invention, lcsh:RC321-571, Randomized controlled trial, law, Anesthesia, Medicine, Neurology (clinical), business, Treatment-resistant depression, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Published
2020

189. Stanford Accelerated Intelligent Neuromodulation Therapy for Treatment-Resistant Depression

Author

Cole, Eleanor J., primary, Stimpson, Katy H., additional, Bentzley, Brandon S., additional, Gulser, Merve, additional, Cherian, Kirsten, additional, Tischler, Claudia, additional, Nejad, Romina, additional, Pankow, Heather, additional, Choi, Elizabeth, additional, Aaron, Haley, additional, Espil, Flint M., additional, Pannu, Jaspreet, additional, Xiao, Xiaoqian, additional, Duvio, Dalton, additional, Solvason, Hugh B., additional, Hawkins, Jessica, additional, Guerra, Austin, additional, Jo, Booil, additional, Raj, Kristin S., additional, Phillips, Angela L., additional, Barmak, Fahim, additional, Bishop, James H., additional, Coetzee, John P., additional, DeBattista, Charles, additional, Keller, Jennifer, additional, Schatzberg, Alan F., additional, Sudheimer, Keith D., additional, and Williams, Nolan R., additional

Published
2020
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198. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease

Author

McConoughey, Stephen J., Basso, Manuela, Niatsetskaya, Zoya V., Sleiman, Sama F., Smirnova, Natalia A., Langley, Brett C., Mahishi, Lata, Cooper, Arthur J. L., Antonyak, Marc A., Cerione, Rick A., Li, Bo, Starkov, Anatoly, Chaturvedi, Rajnish Kumar, Beal, Flint M., Coppola, Giovanni, Geschwind, Daniel H., Ryu, Hoon, Xia, Li, Iismaa, Siiri E., Pallos, Judit, Pasternack, Ralf, Hils, Martin, Fan, Jing, Raymond, Lynn A., Marsh, Lawrence J., Thompson, Leslie M., and Ratan, Rajiv R.

Published
2010
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