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1,282 results on '"Fucharoen, Suthat"'

155. Genotype-Phenotype Correlation of β-Thalassemia in Malaysian Population: Toward Effective Genetic Counseling

Author

Abdullah, Uday Y. H., primary, Ibrahim, Hishamshah M., additional, Mahmud, Noraesah Binti, additional, Salleh, Mohamad Zaki, additional, Teh, Lay Kek, additional, Noorizhab, Mohd Nur Fakhruzzaman bin, additional, Zilfalil, Bin Alwi, additional, Jassim, Haitham Muhammed, additional, Wilairat, Prapin, additional, and Fucharoen, Suthat, additional

Published
2020
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156. High‐level induction of fetal haemoglobin by pomalidomide in β‐thalassaemia/HbE erythroid progenitor cells

Author

Khamphikham, Pinyaphat, primary, Nualkaew, Tiwaporn, additional, Pongpaksupasin, Phitchapa, additional, Kaewsakulthong, Woratree, additional, Songdej, Duantida, additional, Paiboonsukwong, Kittiphong, additional, Engel, James D., additional, Hongeng, Suradej, additional, Fucharoen, Suthat, additional, Sripichai, Orapan, additional, and Jearawiriyapaisarn, Natee, additional

Published
2020
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160. International reproducibility of single breathhold T2* MR for cardiac and liver iron assessment among five thalassemia centers

Author

Kirk, Paul, He, Taigang, Anderson, Lisa J., Roughton, Michael, Tanner, Mark A., Lam, Wynnie W.M., Au, Wing Y., Chu, Winnie C.W., Chan, Godfrey, Galanello, Renzo, Matta, Gildo, Fogel, Mark, Cohen, Alan R., Tan, Ru San, Chen, Kevin, Ng, Ivy, Lai, Angie, Fucharoen, Suthat, Laothamata, Jiraporn, Chuncharunee, Suporn, Jongjirasiri, Sutipong, Firmin, David N., Smith, Gillian C., and Pennell, Dudley J.

Published
2010
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168. Impaired Terminal Erythroid Maturation in β 0 -Thalassemia/HbE Patients with Different Clinical Severity.

Author

Suriyun, Thunwarat, Winichagoon, Pranee, Fucharoen, Suthat, and Sripichai, Orapan

Subjects
IRON deficiency anemia, ERYTHROCYTES, ERYTHROPOIETIN receptors, PROGENITOR cells, RETICULOCYTES, FLOW cytometry
Abstract

Anemia in β-thalassemia is associated with ineffective erythropoiesis and a shortened lifespan of erythroid cells. The limited differentiation of β-thalassemic erythroblasts has been documented, but the characteristic feature of terminal erythroid maturation and its physiological relevance are not clearly described in β-thalassemias. Here, the red blood cell and reticulocyte cellular characteristics were determined in patients with β0-thalassemia/HbE in comparison to patients with iron deficiency anemia and healthy normal subjects. Severely affected β0-thalassemia/HbE patients showed the highest increase in immature reticulocytes, but the number of total erythrocytes was the lowest. Despite similar ranges of hemoglobin levels, β0-thalassemia/HbE patients had a higher number of reticulocytes and a greater proportion of immature fraction than patients with iron deficiency anemia did. In vitro CD34+ hematopoietic progenitor cells' culture and flow cytometry analysis were conducted to investigate the erythroid maturation and mitochondrial clearance in β0-thalassemia/HbE erythroid cells as compared to normal cells. The delayed erythroid maturation and evidence of impaired mitochondria clearance were observed in β0-thalassemia/HbE cells at the terminal stage of differentiation. Additionally, increased transcript levels of genes related to erythroid mitophagy, BNIP3L and PINK1, were revealed in β0-thalassemia/HbE erythroblasts. The findings indicate that the erythroid maturation is physiologically relevant, and that the restoration of terminal maturation represents a potential therapeutic target for β-thalassemias. [ABSTRACT FROM AUTHOR]

Published
2022
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176. Iron metabolism in heterozygotes for hemoglobin E (HbE), [alpha]-thalassemia 1, [beta]-thalassemia and in compound heterozygotes for HbE/[beta]-thalassemia

Author

Zimmermann, Michael B., Fucharoen, Suthat, Winichagoon, Pattanee, Sirankapracha, Pornpan, Zeder, Christophe, Gowachirapant, Sueppong, Judprasong, Kunchit, Tanno, Toshihiko, Miller, Jeffery L., and Hurrell, Richard F.

Subjects
Iron in the body -- Physiological aspects, Iron in the body -- Research, Heterozygosis -- Research, Thalassemia -- Research, Food/cooking/nutrition, Health
Abstract

Background: Despite large populations carrying traits for thalassemia in countries implementing universal iron fortification, there are few data on the absorption and utilization of iron in these persons. Objective: We aimed to determine whether iron absorption or utilization (or both) in women heterozygous for [beta]-thalassemia, [alpha]-thalassemia 1, or hemoglobin E (HbE) differed from that in control subjects and compound HbE/[beta]-thalassemia heterozygotes. Design: In Thai women (n = 103), red blood cell indexes, iron status, non-transferrin-bound iron, and growth differentiation factor 15 were measured, and body iron was calculated. Fractional iron absorption was measured from meals fortified with isotopically labeled ([sup.57]Fe) Fe sulfate, and iron utilization was measured by the infusion of ([sup.58]Fe) Fe citrate. Results: Iron utilization was [approximately equal to] 15% lower in [alpha]-thalassemia 1 or [beta]-thalassemia heterozygotes than in controls. When corrected for differences in serum ferritin, absorption was significantly higher in the [alpha]- and [beta]-thalassemia groups, but not the HbE heterozygotes, than in controls. HbE/[beta]-thalassemia compound heterozygotes had lower iron utilization and higher iron absorption and body iron than did controls. Nontransferrin-bound iron and growth differentiation factor 15 were higher in the compound heterozygotes, but not in the other groups, than in the controls. Conclusions: In [alpha]-thalassemia 1 and [beta]-thalassemia heterozygotes with ineffective erythropoesis, dietary iron absorption is not adequately down-regulated, despite a modest increase in body iron stores. In populations with a high prevalence of these traits, a program of iron fortification could include monitoring for possible iron excess and for iron deficiency.

Published
2008

182. Pathogen-Associated Molecules from Gut Translocation Enhance Severity of Cecal Ligation and Puncture Sepsis in Iron-Overload β-Thalassemia Mice

Author

Sae-khow,Kritsanawan, Charoensappakit,Awirut, Visitchanakun,Peerapat, Saisorn,Wilasinee, Svasti,Saovaros, Fucharoen,Suthat, Leelahavanichkul,Asada, Sae-khow,Kritsanawan, Charoensappakit,Awirut, Visitchanakun,Peerapat, Saisorn,Wilasinee, Svasti,Saovaros, Fucharoen,Suthat, and Leelahavanichkul,Asada

Abstract

Kritsanawan Sae-khow,1 Awirut Charoensappakit,2 Peerapat Visitchanakun,1 Wilasinee Saisorn,2 Saovaros Svasti,3 Suthat Fucharoen,3 Asada Leelahavanichkul2,4 1Medical Microbiology, Interdisciplinary and International Program, Graduate School, Chulalongkorn University, Bangkok, Thailand; 2Translational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand; 3Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand; 4Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandCorrespondence: Asada LeelahavanichkulTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok 10330, ThailandTel +66-2-256-4251Fax +66-2-252-6920Email aleelahavanit@gmail.comIntroduction: Systemic inflammation induced by gut translocation of lipopolysaccharide (LPS), a major component of Gram-negative bacteria, in thalassemia with iron-overload worsens sepsis. However, the impact of (1→ 3)-β-D-glucan (BG), a major fungal molecule, in iron-overload thalassemia is still unclear. Hence, the influence of BG was explored in 1) iron-overload mice with sepsis induced by cecal ligation and puncture (CLP) surgery; and 2) in bone marrow-derived macrophages (BMMs).Methods: The heterozygous β-globin-deficient mice, Hbbth3/+ mice, were used as representative thalassemia (TH) mice. Iron overload was generated by 6 months of oral iron administration before CLP surgery- induced sepsis in TH mice and wild-type (WT) mice. Additionally, BMMs from both mouse strains were used to explore the impact of BG.Results: Without sepsis, iron-overload TH mice demonstrated more severe intestinal mucosal injury (gut leakage) with higher LPS and BG in serum, from gut translocation, when compared with WT mice. With CLP in iron-overload mice, sepsis severity in TH

Published
2020

194. Association of the Degree of Erythroid Expansion and Maturation Arrest with the Clinical Severity of β0-Thalassemia/Hemoglobin E Patients.

Author

Suriyun, Thunwarat, Kaewsakulthong, Woratree, Khamphikham, Pinyaphat, Chumchuen, Sukanya, Hongeng, Suradej, Fucharoen, Suthat, and Sripichai, Orapan

Subjects
GROWTH differentiation factors, ACTIVIN receptors, HEAT shock proteins, CELL division, CELL culture
Abstract

Introduction: β-Thalassemia/hemoglobin E represents one-half of all the clinically severe β-thalassemias worldwide. Despite similar genetic backgrounds, patients show clinical heterogeneity ranging from nearly asymptomatic to transfusion-dependent thalassemia. The underlying disease modifying factors remain largely obscure. Methods: To elucidate the correlation between ineffective erythropoiesis and β0-thalassemia/hemoglobin E (HbE) disease severity, in vitro culture of erythroid cells derived from patients with different clinical symptoms was established. Cell proliferation, viability, and differentiation were investigated. To identify potential molecular mechanisms leading to the arrested erythroid maturation, the expression levels of erythropoiesis modifying factors were measured. Results: The β0-thalassemia/HbE cells exhibited enhanced proliferation, limited differentiation, and impaired erythroid terminal maturation but did not show accelerated erythroblast differentiation and increased cell death. Erythroblasts derived from mild patients showed the highest proliferation rate with a faster cell division time, while erythroblasts derived from severe patients displayed extremely delayed erythroid maturation. Downregulation of growth differentiation factor 11 and FOXO3a was observed in mild β0-thalassemia/HbE erythroblasts, while upregulation of heat shock protein 70 and activin receptor 2A was revealed in severe erythroblasts. Discussion/Conclusion: The degree of erythroid expansion and maturation arrest contributes to the severity of β0-thalassemia/HbE patients, accounting for the disease heterogeneity. The findings suggest a restoration of erythroid maturation as a promising targeted therapy for severe patients. [ABSTRACT FROM AUTHOR]

Published
2021
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199. Impact of the detection of ζ-globin chains and hemoglobin Bart’s using immunochromatographic strip tests for α0-thalassemia (--SEA) differential diagnosis

Author

Pata, Supansa, primary, Laopajon, Witida, additional, Pongpaiboon, Matawee, additional, Thongkum, Weeraya, additional, Polpong, Nattapong, additional, Munkongdee, Thongperm, additional, Paiboonsukwong, Kittiphong, additional, Fucharoen, Suthat, additional, Tayapiwatana, Chatchai, additional, and Kasinrerk, Watchara, additional

Published
2019
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