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2,931 results on '"Fuchs, Michael"'

151. On Kurzweil's 0-1 Law in Inhomogeneous Diophantine Approximation

Author

Fuchs, Michael and Kim, Dong Han

Subjects
Mathematics - Number Theory, 11J83, 11K60, 37E10
Abstract

We give a sufficient and necessary condition such that for almost all $s\in{\mathbb R}$ \[ \|n\theta-s\|<\psi(n)\qquad\text{for infinitely many}\ n\in{\mathbb N}, \] where $\theta$ is fixed and $\psi(n)$ is a positive, non-increasing sequence. This improves upon an old result of Kurzweil and contains several previous results as special cases: two theorems of Kurzweil, a theorem of Tseng and a recent result of the second author. Moreover, we also discuss an analogue of our result in the field of formal Laurent series which has similar consequences., Comment: 12 pages

Published
2015

153. Tumor and microenvironment response but no cytotoxic T-cell activation in classic Hodgkin lymphoma treated with anti-PD1

Author

Reinke, Sarah, Bröckelmann, Paul J., Iaccarino, Ingram, Garcia-Marquez, Maria, Borchmann, Sven, Jochims, Franziska, Kotrova, Michaela, Pal, Karol, Brüggemann, Monika, Hartmann, Elena, Sasse, Stephanie, Kobe, Carsten, Mathas, Stephan, Soekler, Martin, Keller, Ulrich, Bormann, Matthias, Zimmermann, Andreas, Richter, Julia, Fuchs, Michael, von Tresckow, Bastian, Borchmann, Peter, Schlößer, Hans, von Bergwelt-Baildon, Michael, Rosenwald, Andreas, Engert, Andreas, and Klapper, Wolfram

Published
2020
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155. The Migration Pattern of a Short-Tapered Femoral Stem Correlates with the Occurrence of Cortical Hypertrophies: A 10-Year Longitudinal Study Using Ein Bild Röntgen Analyse–Femoral Component Analysis.

Author

Freitag, Tobias, Fuchs, Michael, Friedrich, David, Bieger, Ralf, Reichel, Heiko, and Oltmanns, Moritz

Subjects
*RADIOSTEREOMETRY, *LONGITUDINAL method, *HYPERTROPHY, *PATIENT selection, *TOTAL hip replacement, *SURVIVAL rate
Abstract

Background: Shorter hip stems have shown promising mid-term results but lack long-term data. High rates of distal cortical hypertrophy (CH) have been described, suggesting a more diaphyseal load transmission. This study aimed to determine patient-specific and surgery-related factors influencing CH and their impact on 10-year outcomes. Methods: It included 100 consecutive total hip arthroplasties (THAs) using the Fitmore stem (Zimmer, Warsaw, Indiana), with clinical and radiographic follow-ups at 1, 2, 5, and at least 10 years post-surgery. Results: No revisions were performed due to aseptic loosening after a mean of 11.6 years (range: 10–13.5 years). CH was observed in 26% of hips, primarily in Gruen zones 3 and 5. There was no significant difference in the Harris Hip Score between patients with and without CH. Larger stem sizes and greater axial subsidence significantly correlated with CH occurrence (OD 1.80, (1.13–1.92), p = 0.004; OD 1.47, (1.04–2.08), p = 0.028). The Fitmore stem demonstrated excellent survival rates and favorable outcomes over 10 years. Conclusions: Despite a lower CH rate compared to other studies, significant correlations with stem size and subsidence were identified. This study underscores the importance of patient selection and achieving high primary stability to maintain the metaphyseal anchoring concept. [ABSTRACT FROM AUTHOR]

Published
2024
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156. Auditory Spatial Discrimination and Sound Localization in Single-Sided Deaf Participants Provided with a Cochlear Implant.

Author

Ludwig, Alexandra Annemarie, Meuret, Sylvia, Battmer, Rolf-Dieter, Fuchs, Michael, Ernst, Arneborg, and Schönwiesner, Marc

Subjects
DIRECTIONAL hearing, COCHLEAR implants, ACOUSTIC localization, HEARING disorders, BURST noise
Abstract

Introduction: Spatial hearing is most accurate using both ears, but accuracy decreases in persons with asymmetrical hearing between ears. In participants with deafness in one ear but normal hearing in the other ear (single-sided deafness [SSD]), this difference can be compensated by a unilateral cochlear implant (CI). It has been shown that a CI can restore sound localization performance, but it is still unclear to what extent auditory spatial discrimination can be improved. Methods: The present study investigated auditory spatial discrimination using minimum audible angles (MAAs) in 18 CI-SSD participants. Results were compared to 120 age-matched normal-hearing (NH) listeners. Low-frequency (LF) and high-frequency (HF) noise bursts were presented from 4°, 30°, and 60° azimuth on the CI side and on the NH side. MAA thresholds were tested for correlation with localization performance in the same participants. Results: There were eight good performers and ten poor performers. There were more poor performers for LF signals than for HF signals. Performance on the CI side was comparable to performance on the NH side. Most difficulties occurred at 4° and at 30°. Eight of the good performers in the localization task were also good performers in the MAA task. Only the localization ability at 4° on the CI side was positively correlated with the MAA at that location. Conclusion: Our data suggest that a CI can restore localization ability but not necessarily auditory spatial discrimination at the same time. The ability to discriminate between adjacent locations may be trainable during rehabilitation to enhance important auditory skills. [ABSTRACT FROM AUTHOR]

Published
2024
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158. Selonsertib for patients with bridging fibrosis or compensated cirrhosis due to NASH: Results from randomized phase III STELLAR trials

Author

Gadano, Adrian, Martins, Marcelo, Angus, Peter, Bate, John, Danta, Mark, George, Jacob, Hodge, Alexander, Kontorinis, Nickolas, Roberts, Stuart, Sanagapalli, Santosh, Skoien, Richard, Thompson, Alexander, Zekry, Amany, Stauber, Rudolf, Trauner, Michael, Moreno, Christophe, Reynaert, Hendrik, Verbeke, Len, Silva, Mario Reis Alvares da, Parise, Edison, Oliveira, Claudia Pinto Marques Souza de, Araujo, Roberta Chaves, Martinelli, Ana de Lourdes Candolo, Borman, Meredith, Chandok, Natasha, Elkhashab, Magdy, Fraser, Hughie, Kaita, Kelly, Ma, Mang, Marotta, Paul, Ramji, Alnoor, Tam, Edward, Yoshida, Eric, Swain, Mark, Sebastiani, Giada, Petrunia, Denis, Abergel, Armando, Anty, Rodolphe, Bourlière, Marc, Boursier, Jérôme, Bureau, Christophe, Castera, Laurent, Habersetzer, François, Hézode, Christophe, Ledinghen, Victor De, Leroy, Vincent, Loustaud-Ratti, Véronique, Mathurin, Philippe, Pol, Stanislas, Zoulim, Fabien, Hinrichsen, Holger, Ingiliz, Patrick, Lammert, Frank, Manns, Michael, Schattenberg, Jörn, Schiefke, Ingolf, Trautwein, Christian, Zeuzem, Stefan, Hui, Aric, Li, King-Kong, Wong, Vincent, Acharya, Subrat, Chowdhury, Abhijit, Duseja, Ajay, Kapoor, Dharmesh, Mukewar, Shrikant, Sarin, Shiv, Shah, Samir, Shalimar, Sood, Ajit, Tantry, BV, Ben-Ari, Ziv, Katchman, Helena, Safadi, Rifaat, Veitsman, Ella, Zuckerman, Eli, Brunetto, Maurizia, Lampertico, Pietro, Mangia, Alessandra, Akahane, Takemi, Akuta, Norio, Eguchi, Yuichiro, Fujiyama, Shigetoshi, Genda, Takuya, Hiasa, Yoichi, Ido, Akio, Ikeda, Fusao, Ikegami, Tadashi, Imajo, Kento, Itoh, Yoshito, Iwasa, Motoh, Karino, Yoshiyasu, Kato, Naoya, Kawaguchi, Takumi, Kawanaka, Miwa, Kido, Masahiro, Kobayashi, Tomoo, Kurosaki, Masayuki, Matsuzaki, Yasushi, Mita, Eiji, Mizukoshi, Eishiro, Nakahara, Takashi, Nomura, Hideyuki, Notsumata, Kazuo, Okanoue, Takeshi, Saito, Satoshi, Sakugawa, Hiroshi, Suzuki, Yoshiyuki, Takaguchi, Koichi, Takaki, Akinobu, Takashima, Tomoyuki, Tanaka, Saiyu, Tsuji, Keiji, Ueno, Yoshiyuki, Umemura, Takeji, Uto, Hirofumi, Yamashita, Nobuyuki, Yanase, Mikio, Yatsuhashi, Hiroshi, Yoneda, Masashi, Chan, Wah Kheong, Tan, Soek Siam, Garza, Laura Cisneros, Ladron De Guevara Cetina, Alma, Angeles, Rocio Guadalupe Vargas, Silva, Francisca Martinez, Van Erpecum, Karel, Orr, David, Jabłkowski, Maciej, Jaroszewicz, Jerzy, Ramos, Jose, Ahmed, Taufique, Ang, Tiing, Dan, Yock young, Goh, Boon Bee, Kaliyaperumal, Kalaiyarasi, Yip, Cherng Hann, Baik, Soon Koo, Jang, Byoung Kuk, Jun, Dae Won, Kim, Won, Kim, Hyung Joon, Kim, Ji Hoon, Lee, Kwan Sik, Lee, Chun Kyon, Lim, Young-Suk, Park, Jun Yong, Tak, Won Young, Augustin, Salvador, Perez, Salvador Benlloch, Caballeria, Juan, Luis, Jose, Panero, Calleja, Rodríguez, Jose Carrión, Garcia, Javier Crespo, Samaniego, Javier Garcia, Gibert, Pere Ginès, Prieto, Martin, Gomez, Manuel Romero, Turnes, Juan, Dufour, Jean-Francois, Moriggia, Alberto, Sheen, I-Shyan, Kao, Jia-Horng, Cheng, Pin-Nan, Huang, Jee-Fu, Yang, Sheng-Shun, Su, Wei-Wen, Chen, Chi-Yi, Chien, Rong-Nan, Lo, Gin-Ho, Chu, Chi-Jen, Wang, Horng-Yuan, Hu, Jui-Ting, Huang, Yi Wen, Agarwal, Kosh, Allison, Michael, Anstee, Quentin, Austin, Andrew, Fowell, Andrew, Ch'ng, Chin Lye, Manousou, Pinelopi, Newsome, Philip, Ryder, Stephen, Shankar, Arun, Abdelmalek, Manal, Abrams, Gary, Aguilar, Humberto, Alam, Imtiaz, Alba, Laura, Alkhouri, Naim, Allen, Alina, Aqel, Bashar, Balart, Luis, Barritt, A. Sidney, IV, Behari, Jaideep, Bennett, Michael, Bernstein, David, Bhandari, Bal Raj, Bonacini, Maurizio, Borg, Brian, Brown, Kimberly, Bzowej, Natalie, Caldwell, Stephen, Chami, Tawfik, Coates, Allan, Cueli, Adolfo, Davis, Mitchell, deLemos, Andrew, Desai, Archita, Dunn, Winston, Ferreira, Nelson, Fine, Michael, Firpi-Morell, Roberto, Freedland, Curtis, Freilich, Bradley, Fuchs, Michael, Galambos, Michael, Gallegos-Orozco, Juan, Galler, Greg, Ghali, Maged, Ghalib, Reem, Gill, Satinder, Gillis, Marcum, Gilroy, Richard, Gordon, Stuart, Gunn, Nadege, Halegoua-DeMarzio, Dina, Hassan, Mohamed, Hassanein, Tarek, Herring, Robert, Jr., Hong, John, Huang, Jonathan, Kabler, Heidi, Kayali, Zeid, Knapple, Whitfield, Kolli, Geetha, Kowdley, Kris, Krause, Richard, Lawitz, Eric, Lidofsky, Steven, Lim, Joseph, Lipkis, Donald, Loomba, Rohit, Mahgoub, Amar, Malespin, Miguel, Manch, Richard, Mannis, Steven, Manos, Paul, McDonald, Thomas, McKenzie, Mark, Mena, Edward, Merriman, Raphael, Moehlen, Martin William, Montgomery, Richard, Murphy, Robert, Natarajan, Yamini, Neff, Guy, Noureddin, Mazen, Ortiz-Lasanta, Grisell, Pagadala, Mangesh, Patel, Keyur, Patton, Heather, Peyton, Adam, Pimstone, Neville, Poulos, John, Pound, David, Pyrsopoulos, Nikolaos, Rafiq, Nila, Ravendhran, Natarajan, Ravinuthala, Ravi, Reddy, K. Rajendar, Reindollar, Robert, Reynolds, Justin, Rinella, Mary, Rizvi, Syed, Rockey, Don, Rodriguez-Perez, Federico, Ruane, Peter, Rubin, Raymond, Ryan, Michael, Saeian, Kia, Sanyal, Arun, Sarkar, Souvik, Scanga, Andrew, Schiff, Eugene, Schmidt, Warren, Schneider, Jeffrey, Sepe, Thomas, Shah, Dhiren, Shaikh, Obaid, Shankar, Uday, Sheikh, Aasim, Sheikh, Muhammad, Sherman, Kenneth, Shiffman, Mitchell, Siddique, Asma, Smith, Matthew, Suarez, Rosa, Talal, Andrew, Te, Helen, Tekola, Bezawit, Tetri, Brent, Thuluvath, Paul, Toro, Doris, Torres, Dawn, Trinh, Huy, Trotter, James, Vento, Angel, Vierling, John, Vuppalanchi, Raj, Waters, Michael, Weisberg, Ilan, Wieland, Amanda, Williams, Alonzo, Younes, Ziad, Adams, Leon, Harding, Damian, Hodge, Alex, Kontorinis, Nick, Strasser, Simone, Thompson, Alex, Horsmans, Yves, Steenkiste, Christophe Van, Bailey, Robert, Giard, Jeanne-Marie, Montano-Loza, Aldo, Puglia, Marco, Tsoi, Keith, Larrey, Dominique, Nguyen-Khac, Eric, Ratziu, Vlad, Spengler, Ulrich, Wiegand, Johannes, Hui, Aric Josun, Acharya, Subrat Kumar, Sarin, Shiv Kumar, Tantry, Vishwanath, Braun, Marius, Hazzan, Rawi, Lurie, Yoav, Colombo, Massimo, Fujii, Hideki, Hashimoto, Etsuko, Kato, Masaki, Ogawa, Koji, Takehara, Tetsuo, Tokushige, Katsutoshi, Garza, Laura Esthela Cisneros, Ladrón De Guevara, Alma Laura, Schultz, Michael, Janczewska, Ewa, Toro, Doris H., Jeong, Sook-Hyang, Kim, Yoon Jun, Lee, Jin-Woo, Ang, Tiing Leong, Bee, George Goh Boon, Benlloch, Salvador, Caballería, Juan, Calleja, José Luis, Rodríguez, Jose A. Carrión, Crespo, Javier, Diago, Moises, Fernandez-Rodriguez, Conrado, García-Samaniego, Javier, Ginès, Pere, Romero, Manuel, Dufour, Jean-François, Alazawi, William, Ch'ng, Chin-Lye, Forton, Daniel, Priest, Matthew, Sheridan, David, Ankoma-Sey, Victor, Balakrishnan, Maya, Bambha, Kiran, Barritt, A. Sidney, Bhandari, Bal, Brandman, Danielle, Chang, Charissa, Corey, Kathleen, Feldman, Michael, Gholam, Pierre, Goff, John, Marzio, Dina Halegoua-De, Harrison, Stephen, Hellstern, Paul, Jr., Herring, Robert, Iyer, Rajalakshmi, Jakiche, Antoine, Kohli, Anita, Krok, Karen, Kugelmas, Marcelo, Kumar, Sonal, Lai, Michelle, Mahmoud, Mitchell, Mantry, Parvez, Marsano, Luis, Nguyen, Tuan, Park, James, Patton, Heather M., Pockros, Paul, Reddy, Rajender, Rodriguez, Miguel, Sarles, Harry, Satapathy, Sanjaya, Sedghi, Shahriar, Shah, Nikunj, Sheikh, Muhammad Yasin, Sigal, Samuel, Stanca, Carmen, Steinbook, Michael, Szabo, Gyongyi, Terrault, Norah, Tong, Myron, Victor, David, Zervos, Xaralambos, Harrison, Stephen A., Wong, Vincent Wai-Sun, Caldwell, Stephen H., Shiffman, Mitchell L., Camargo, Marianne, Li, Georgia, Kersey, Kathryn, Jia, Catherine, Zhu, Yanni, Djedjos, C. Stephen, Subramanian, G. Mani, Myers, Robert P., Anstee, Quentin M., Romero-Gomez, Manuel, Goodman, Zachary, Lawitz, Eric J., and Younossi, Zobair

Published
2020
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159. Answer to the Letter to the Editor of Tugba Ozudogru Celik concerning “Association between posterior tibial slope and anatomic spinopelvic parameters: a retrospective cross-sectional study” by Caffard T, et al. (Eur Spine J. 2023; doi: 10.1007/s00586-023-07830-1)

Author

Caffard, Thomas, primary, Awan Malik, Hassan, additional, Lutz, Bernd, additional, Dobrindt, Oliver, additional, Dornacher, Daniel, additional, Faschingbauer, Martin, additional, Strube, Patrick, additional, Reichel, Heiko, additional, Fuchs, Michael, additional, and Zippelius, Timo, additional

Published
2023
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161. Alterations in gut virome are associated with cognitive function and minimal hepatic encephalopathy cross-sectionally and longitudinally in cirrhosis

Author

Jinato, Thananya, primary, Sikaroodi, Masoumeh, additional, Fagan, Andrew, additional, Sterling, Richard K, additional, Lee, Hannah, additional, Puri, Puneet, additional, Davis, Brian C, additional, Fuchs, Michael, additional, Gavis, Edith, additional, Gillevet, Patrick M, additional, and Bajaj, Jasmohan S, additional

Published
2023
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163. Follow-up of the GHSG HD16 trial of PET-guided treatment in early-stage favorable Hodgkin lymphoma

Author

Fuchs, Michael, primary, Jacob, Anne Sophie, additional, Kaul, Helen, additional, Kobe, Carsten, additional, Kuhnert, Georg, additional, Pabst, Thomas, additional, Greil, Richard, additional, Bröckelmann, Paul J., additional, Topp, Max S., additional, Just, Marianne, additional, Hertenstein, Bernd, additional, Soekler, Martin, additional, Vogelhuber, Martin, additional, Zijlstra, Josée M., additional, Keller, Ulrich Bernd, additional, Krause, Stefan W., additional, Dührsen, Ulrich, additional, Meissner, Julia, additional, Viardot, Andreas, additional, Eich, Hans-Theodor, additional, Baues, Christian, additional, Diehl, Volker, additional, Rosenwald, Andreas, additional, Buehnen, Ina, additional, von Tresckow, Bastian, additional, Dietlein, Markus, additional, Borchmann, Peter, additional, Engert, Andreas, additional, and Eichenauer, Dennis A., additional

Published
2023
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164. S1323 Plant-Based Meals Generate Lower Ammonia and Have a Unique Metabolomic Signature Compared to Meat-Based Meals Despite Similar Baseline Microbiome in Patients With Cirrhosis: A Randomized Clinical Trial

Author

Badal, Bryan D., primary, Fagan, Andrew, additional, Tate, Victoria, additional, Mousel, Travis, additional, Gallagher, Mary Leslie, additional, Puri, Puneet, additional, Fuchs, Michael, additional, Davis, Brian, additional, Miller, Jennifer, additional, Sikaroodi, Masoumeh, additional, Gillevet, Patrick, additional, Thacker, Leroy, additional, and Bajaj, Jasmohan, additional

Published
2023
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168. Non-associative Deformations of Geometry in Double Field Theory

Author

Blumenhagen, Ralph, Fuchs, Michael, Hassler, Falk, Lust, Dieter, and Sun, Rui

Subjects
High Energy Physics - Theory, Mathematical Physics
Abstract

Non-geometric string backgrounds were proposed to be related to a non-associative deformation of the space-time geometry. In the flux formulation of double field theory (DFT), the structure of mathematically possible non-associative deformations is analyzed in detail. It is argued that on-shell there should not be any violation of associativity in the effective DFT action. For imposing either the strong or the weaker closure constraint we discuss two possible non-associative deformations of DFT featuring two different ways how on-shell associativity can still be kept., Comment: 29 pages, 1 figure, v2: major revision of section 4, discussion of closure constraint changed

Published
2013
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169. Alterations in Skin Microbiomes of Patients With Cirrhosis

Author

Bajaj, Jasmohan S., Fagan, Andrew, Sikaroodi, Masoumeh, Kakiyama, Genta, Takei, Hajme, Degefu, Yordanos, Pandak, William M., Hylemon, Phillip B., Fuchs, Michael, John, Binu, Heuman, Douglas M., Gavis, Edith, Nittono, Hiroshi, Patil, Rohan, and Gillevet, Patrick M.

Published
2019
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179. A binomial splitting process in connection with corner parking problems

Author

Fuchs, Michael, Hwang, Hsien-Kuei, Itoh, Yoshiaki, and Mahmoud, Hosam H.

Subjects
Mathematics - Probability, 60C05, 60F05, 68W40
Abstract

A special type of binomial splitting process is studied. Such a process can be used to model a high-dimensional corner parking problem, as well as the depth of random PATRICIA tries (a special class of digital tree data structures). The later also has natural interpretations in terms of distinct values in iid geometric random variables and the occupancy problem in urn models. The corresponding distribution is marked by logarithmic mean and bounded variance, which is oscillating, if the binomial parameter $p$ is not equal to 1/2, and asymptotic to 1 in the unbiased case. Also, the limiting distribution does not exist owing to periodic fluctuations., Comment: 20 pages

Published
2013

180. An analytic approach to the asymptotic variance of trie statistics and related structures

Author

Fuchs, Michael, Hwang, Hsien-Kuei, and Zacharovas, Vytas

Subjects
Mathematics - Combinatorics, Computer Science - Data Structures and Algorithms
Abstract

We develop analytic tools for the asymptotics of general trie statistics, which are particularly advantageous for clarifying the asymptotic variance. Many concrete examples are discussed for which new Fourier expansions are given. The tools are also useful for other splitting processes with an underlying binomial distribution. We specially highlight Philippe Flajolet's contribution in the analysis of these random structures., Comment: 51 pages, the expressions of all Fourier coefficients are largely simplified in this version

Published
2013

192. Asymptotic variance of random symmetric digital search trees

Author

Hwang, Hsien-Kuei, Fuchs, Michael, and Zacharovas, Vytas

Subjects
Mathematics - Combinatorics, Mathematics - Probability
Abstract

Asymptotics of the variances of many cost measures in random digital search trees are often notoriously messy and involved to obtain. A new approach is proposed to facilitate such an analysis for several shape parameters on random symmetric digital search trees. Our approach starts from a more careful normalization at the level of Poisson generating functions, which then provides an asymptotically equivalent approximation to the variance in question. Several new ingredients are also introduced such as a combined use of the Laplace and Mellin transforms and a simple, mechanical technique for justifying the analytic de-Poissonization procedures involved. The methodology we develop can be easily adapted to many other problems with an underlying binomial distribution. In particular, the less expected and somewhat surprising $n(\log n)^2$-variance for certain notions of total path-length is also clarified.

Published
2009

194. Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance).

Author

Ogino, Shuji, Wu, Kana, Willett, Walter, Giovannucci, Edward, Meyerhardt, Jeffrey, Fuchs, Michael, Sato, Kaori, Niedzwiecki, Donna, Ye, Xing, Saltz, Leonard, Mayer, Robert, Mowat, Rex, Whittom, Renaud, Hantel, Alexander, Benson, Al, Atienza, Daniel, Messino, Michael, Kindler, Hedy, and Venook, Alan

Subjects
Adult, Aged, Aged, 80 and over, Beverages, Colonic Neoplasms, Dietary Sucrose, Female, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Proportional Hazards Models, Risk Factors, Sweetening Agents, Young Adult
Abstract

BACKGROUND: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown. METHODS: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models. RESULTS: Patients consuming ≥ 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming

Published
2014

196. Cholestenoic acid as endogenous epigenetic regulator decreases hepatocyte lipid accumulation in vitro and in vivo.

Author

Yaping Wang, Pandak, Williams M., Hylemon, Phillip B., Hae-Ki Min, Min, John, Fuchs, Michael, Sanyal, Arun J., and Shunlin Ren

Subjects
CARNOSIC acid, LIPIDS, DNA methyltransferases, EPIGENETICS, CHOLESTEROL metabolism, LIPID metabolism
Abstract

Cholestenoic acid (CA) has been reported as an important biomarker of many severe diseases, but its physiological and pathological roles remain unclear. This study aimed to investigate the potential role of CA in hepatic lipid homeostasis. Enzyme kinetic studies revealed that CA specifically activates DNA methyltransferases 1 (DNMT1) at low concentration with EC50 = 1.99 10-6 M and inhibits the activity at higher concentration with IC50 = 9.13 106 M, and specifically inhibits DNMT3a, and DNMT3b activities with IC50= 8.41 10-6 M and IC50= 4.89 10-6 M, respectively. In a human hepatocyte in vitro model of high glucose (HG)- induced lipid accumulation, CA significantly increased demethylation of 5mCpG in the promoter regions of over 7,000 genes, particularly those involved in master signaling pathways such as calcium-AMPK and 0.0027 at 6 h. RNA sequencing analysis showed that the downregulated genes are affected by CA encoding key enzymes, such as PCSK9, MVK, and HMGCR, which are involved in cholesterol metabolism and steroid biosynthesis pathways. In addition, untargeted lipidomic analysis showed that CA significantly reduced neutral lipid levels by 60% in the cells cultured in high-glucose media. Administration of CA in mouse metabolic dysfunction-associated steatotic liver disease (MASLD) models significantly decreases lipid accumulation, suppresses the gene expression involved in lipid biosynthesis in liver tissues, and alleviates liver function. This study shows that CA as an endogenous epigenetic regulator decreases lipid accumulation via epigenetic regulation. The results indicate that CA can be considered a potential therapeutic target for the treatment of metabolic disorders. NEW & NOTEWORTHY To our knowledge, this study is the first to identify the mitochondrial monohydroxy bile acid cholestenoic acid (CA) as an endogenous epigenetic regulator that regulates lipid metabolism through epigenome modification in human hepatocytes. The methods used in this study are all big data analysis, and the results of each part show the global regulation of CA on human hepatocytes rather than narrow point effects. [ABSTRACT FROM AUTHOR]

Published
2024
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197. Developing the test of inquiry skills: measuring the level of inquiry skills among pupils in Slovakia.

Author

Šmida, Dominik, Čipková, Elena, and Fuchs, Michael

Subjects
INQUIRY-based learning, SCIENCE education, TEACHER development, LEARNING strategies, EDUCATION research
Abstract

Teachers can develop science literacy among pupils through Inquiry-Based Science Education. IBSE helps to evolve the inquiry skills necessary for understanding the world of science and nature. To be able to improve the level of inquiry skills systematically, we need to know the current level among pupils. For this reason, we designed a multiple-choice test that measures the level of inquiry skills among 13 to 15 years old pupils. The design of the test consisted of six steps: selection of inquiry skills, construction and administration of open-ended test, creation of a database of distractors, construction of multiple-choice test, pilot testing and application of optimised test in pedagogical research. The designed test can be considered a valid and reliable research instrument and the individual test items show a relatively high discriminating power, optimal level of difficulty and a high number of functional distractors. By analysing the most common incorrect answers, we were able to identify various difficulties pupils have, regarding the application of inquiry skills in solving items. These results will help us to design appropriate strategies for improving pupils' inquiry skills in science education. [ABSTRACT FROM AUTHOR]

Published
2024
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198. Limit theorems for patterns in ranked tree-child networks.

Author

Fuchs, Michael, Hexuan Liu, and Tsan-Cheng Yu

Subjects
DIFFRACTION patterns, PATTERNS (Mathematics), MOMENTS method (Statistics)
Abstract

We prove limit laws for the number of occurrences of a pattern on the fringe of a ranked tree-child network which is picked uniformly at random. Our results extend the limit law for cherries proved by Bienvenu et al. (Random Struct. Algoritm. 60 (2022), no. 4, 653–689). For patterns of height 1 and 2, we show that they either occur frequently (mean is asymptotically linear and limit law is normal) or sporadically (mean is asymptotically constant and limit law is Poisson) or not all (mean tends to 0 and limit law is degenerate). We expect that these are the only possible limit laws for any fringe pattern. [ABSTRACT FROM AUTHOR]

Published
2024
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200. P21 A Specialized Hepatic Encephalopathy Testing Clinic Improves Rational Decision Making for HE Therapy and Can Detect Alternative Causes for Cognitive Impairment in Cirrhosis

Author

Badal, Bryan, primary, Tafader, Asiya, additional, Nadeem, Mahum, additional, Park, Dan, additional, Fagan, Andrew, additional, Davis, Brian, additional, Fuchs, Michael, additional, Puri, Puneet, additional, Gilles, HoChong, additional, Miller, Jennifer, additional, Tinsley, Felicia, additional, and Bajaj, Jasmohan S., additional

Published
2023
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