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Your search keyword '"Giroux, M."' showing total 824 results
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824 results on '"Giroux, M."'

151. Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study

Author

Wilk, J. B., primary, Tobin, J. E., additional, Suchowersky, O., additional, Shill, H. A., additional, Klein, C., additional, Wooten, G. F., additional, Lew, M. F., additional, Mark, M. H., additional, Guttman, M., additional, Watts, R. L., additional, Singer, C., additional, Growdon, J. H., additional, Latourelle, J. C., additional, Saint-Hilaire, M. H., additional, DeStefano, A. L., additional, Prakash, R., additional, Williamson, S., additional, Berg, C. J., additional, Sun, M., additional, Goldwurm, S., additional, Pezzoli, G., additional, Racette, B. A., additional, Perlmutter, J. S., additional, Parsian, A., additional, Baker, K. B., additional, Giroux, M. L., additional, Litvan, I., additional, Pramstaller, P. P., additional, Nicholson, G., additional, Burn, D. J., additional, Chinnery, P. F., additional, Vieregge, P., additional, Slevin, J. T., additional, Cambi, F., additional, MacDonald, M. E., additional, Gusella, J. F., additional, Myers, R. H., additional, and Golbe, L. I., additional

Published
2006
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152. 2546

Author

Carbonneau, A., primary, Donath, D., additional, Therasse, E., additional, Soulez, G., additional, Lespérance, J., additional, Giroux, M., additional, Tardif, J.C., additional, Oliva, V.L., additional, Fortin, B., additional, and Bahary, J.P., additional

Published
2006
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153. The UV spectrum of HS 1700+6416

Author

Fechner, C., primary, Reimers, D., additional, Kriss, G. A., additional, Baade, R., additional, Blair, W. P., additional, Giroux, M. L., additional, Green, R. F., additional, Moos, H. W., additional, Morton, D. C., additional, Scott, J. E., additional, Shull, J. M., additional, Simcoe, R., additional, Songaila, A., additional, and Zheng, W., additional

Published
2006
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158. BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study

Author

Karamohamed, S., primary, Latourelle, J. C., additional, Racette, B. A., additional, Perlmutter, J. S., additional, Wooten, G. F., additional, Lew, M., additional, Klein, C., additional, Shill, H., additional, Golbe, L. I., additional, Mark, M. H., additional, Guttman, M., additional, Nicholson, G., additional, Wilk, J. B., additional, Saint-Hilaire, M., additional, DeStefano, A. L., additional, Prakash, R., additional, Tobin, S., additional, Williamson, J., additional, Suchowersky, O., additional, Labell, N., additional, Growdon, B.N.J., additional, Singer, C., additional, Watts, R., additional, Goldwurm, S., additional, Pezzoli, G., additional, Baker, K. B., additional, Giroux, M. L., additional, Pramstaller, P. P., additional, Burn, D. J., additional, Chinnery, P., additional, Sherman, S., additional, Vieregge, P., additional, Litvan, I., additional, Gusella, J. F., additional, Myers, R. H., additional, and Parsian, A., additional

Published
2005
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168. Wheat.

Author

Nagata, Toshiyuki, Lörz, Horst, Widholm, Jack M., Pua, Eng-Chong, Davey, Michael R., Meyer, F. D., and Giroux, M. J.

Published
2007
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171. Resolving the Structure of Ionized Helium in the Intergalactic Medium with the Far Ultraviolet Spectroscopic Explorer

Author

Kriss, G. A., primary, Shull, J. M., additional, Oegerle, W., additional, Zheng, W., additional, Davidsen, A. F., additional, Songaila, A., additional, Tumlinson, J., additional, Cowie, L. L., additional, Deharveng, J.-M., additional, Friedman, S. D., additional, Giroux, M. L., additional, Green, R. F., additional, Hutchings, J. B., additional, Jenkins, E. B., additional, Kruk, J. W., additional, Moos, H. W., additional, Morton, D. C., additional, Sembach, K. R., additional, and Tripp, T. M., additional

Published
2001
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199. The TGF-β-Smad3 pathway inhibits CD28-dependent cell growth and proliferation of CD4 T cells.

Author

Delisle, J-S, Giroux, M, Boucher, G, Landry, J-R, Hardy, M-P, Lemieux, S, Jones, R G, Wilhelm, B T, and Perreault, C

Subjects
*TRANSFORMING growth factors-beta, *CD28 antigen, *GROWTH factors, *CELL proliferation, *CD4 antigen, *T cells, *IMMUNOREGULATION, *SMAD proteins
Abstract

Transforming growth factor-β (TGF-β) maintains self-tolerance through a constitutive inhibitory effect on T-cell reactivity. In most physiological situations, the tolerogenic effects of TGF-β depend on the canonical signaling molecule Smad3. To characterize how TGF-β/Smad3 signaling contributes to maintenance of T-cell tolerance, we characterized the transcriptional landscape downstream of TGF-β/Smad3 signaling in resting or activated CD4 T cells. We report that in the presence of TGF-β, Smad3 modulates the expression of >400 transcripts. Notably, we identified 40 transcripts whose expression showed Smad3 dependence in both resting and activated cells. This 'signature' confirmed the non-redundant role of Smad3 in TGF-β biology and identified both known and putative immunoregulatory genes. Moreover, we provide genomic and functional evidence that the TGF-β/Smad3 pathway regulates T-cell activation and metabolism. In particular, we show that TGF-β/Smad3 signaling dampens the effect of CD28 stimulation on T-cell growth and proliferation. The impact of TGF-β/Smad3 signals on T-cell activation was similar to that of the mTOR inhibitor Rapamycin. Considering the importance of co-stimulation on the outcome of T-cell activation, we propose that TGF-β-Smad3 signaling may maintain T-cell tolerance by suppressing co-stimulation-dependent mobilization of anabolic pathways. [ABSTRACT FROM AUTHOR]

Published
2013
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