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151. Supplementary Figure 1 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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152. Data from PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Author

Yacoub, Adly, primary, Hamed, Hossein A., primary, Allegood, Jeremy, primary, Mitchell, Clint, primary, Spiegel, Sarah, primary, Lesniak, Maciej S., primary, Ogretmen, Besim, primary, Dash, Rupesh, primary, Sarkar, Devanand, primary, Broaddus, William C., primary, Grant, Steven, primary, Curiel, David T., primary, Fisher, Paul B., primary, and Dent, Paul, primary

Published
2023
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153. Supplementary Figure 1 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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154. Supplementary Figure 8 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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155. Data from Mechanism by Which Mcl-1 Regulates Cancer-Specific Apoptosis Triggered by mda-7/IL-24, an IL-10–Related Cytokine

Author

Dash, Rupesh, primary, Richards, Joanna E., primary, Su, Zhao-zhong, primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Rahmani, Mohamed, primary, Dasmahapatra, Girija, primary, Yacoub, Adly, primary, Dent, Paul, primary, Dmitriev, Igor P., primary, Curiel, David T., primary, Grant, Steven, primary, Pellecchia, Maurizio, primary, Reed, John C., primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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156. Supplementary Figures 1-8 from Vorinostat and Sorafenib Increase CD95 Activation in Gastrointestinal Tumor Cells through a Ca2+-De novo Ceramide-PP2A-Reactive Oxygen Species–Dependent Signaling Pathway

Author

Park, Margaret A., primary, Mitchell, Clint, primary, Zhang, Guo, primary, Yacoub, Adly, primary, Allegood, Jeremy, primary, Häussinger, Dieter, primary, Reinehr, Roland, primary, Larner, Andrew, primary, Spiegel, Sarah, primary, Fisher, Paul B., primary, Voelkel-Johnson, Christina, primary, Ogretmen, Besim, primary, Grant, Steven, primary, and Dent, Paul, primary

Published
2023
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157. Supplementary Figure 2 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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158. Supplementary Figure 4 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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160. Supplementary Figure 6 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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161. Supplementary Figures 1-11 from PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda-7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

Author

Yacoub, Adly, primary, Hamed, Hossein A., primary, Allegood, Jeremy, primary, Mitchell, Clint, primary, Spiegel, Sarah, primary, Lesniak, Maciej S., primary, Ogretmen, Besim, primary, Dash, Rupesh, primary, Sarkar, Devanand, primary, Broaddus, William C., primary, Grant, Steven, primary, Curiel, David T., primary, Fisher, Paul B., primary, and Dent, Paul, primary

Published
2023
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163. Supplementary Figure 7 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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164. Supplementary Video 3 from CDK Inhibitors Upregulate BH3-Only Proteins to Sensitize Human Myeloma Cells to BH3 Mimetic Therapies

Author

Chen, Shuang, primary, Dai, Yun, primary, Pei, Xin-Yan, primary, Myers, Jennifer, primary, Wang, Li, primary, Kramer, Lora B., primary, Garnett, Mandy, primary, Schwartz, Daniella M., primary, Su, Florence, primary, Simmons, Gary L., primary, Richey, Justin D., primary, Larsen, Dustin G., primary, Dent, Paul, primary, Orlowski, Robert Z., primary, and Grant, Steven, primary

Published
2023
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166. Supplementary Figure Legend from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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167. Supplementary Methods, Figures 1-4 from Mechanism of Autophagy to Apoptosis Switch Triggered in Prostate Cancer Cells by Antitumor Cytokine Melanoma Differentiation-Associated Gene 7/Interleukin-24

Author

Bhutia, Sujit K., primary, Dash, Rupesh, primary, Das, Swadesh K., primary, Azab, Belal, primary, Su, Zhao-zhong, primary, Lee, Seok-Geun, primary, Grant, Steven, primary, Yacoub, Adly, primary, Dent, Paul, primary, Curiel, David T., primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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168. Supplementary Figure 2 from MDA-9/Syntenin and IGFBP-2 Promote Angiogenesis in Human Melanoma

Author

Das, Swadesh K., primary, Bhutia, Sujit K., primary, Azab, Belal, primary, Kegelman, Timothy P., primary, Peachy, Leyla, primary, Santhekadur, Prasanna K., primary, Dasgupta, Santanu, primary, Dash, Rupesh, primary, Dent, Paul, primary, Grant, Steven, primary, Emdad, Luni, primary, Pellecchia, Maurizio, primary, Sarkar, Devanand, primary, and Fisher, Paul B., primary

Published
2023
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170. Phase 1 study of belinostat and adavosertib in patients with relapsed or refractory myeloid malignancies

Author

Shafer, Danielle, primary, Kagan, Amanda B., additional, Rudek, Michelle A., additional, Kmieciak, Maciej, additional, Tombes, Mary Beth, additional, Shrader, Ellen, additional, Bandyopadhyay, Dipankar, additional, Hudson, Daniel, additional, Sankala, Heidi, additional, Weir, Caryn, additional, Lancet, Jeffrey E., additional, and Grant, Steven, additional

Published
2023
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175. Construction & expression in E. coli of novel single-chain antibody fragments against the herbicide atrazine

Author

Grant, Steven D.

Subjects
628.55, Land pollution & soil pollution
Abstract

The objective of this research was to determine the potential of two anti-atrazine single-chain antibodies (scAbs) to detect very dilute atrazine concentration, specifically in the nanomolar and sub-nanomolar ranges. Analysis of environmental pesticide contamination is routinely done by high performance liquid chromatography (HPLC), gas chromatography (GC) and mass spectrometry (MS). However, since the mid eighties there have been an increasing number of reports describing the use immunoassays to detect environmental pollutants. Although immunoanalysis using whole antibodies has been shown to be almost as effective as GC/MS (Thurman et al., 1990) the technology is still not widely used for pesticide analysis. This thesis will describe the increased sensitivity of single-chain antibody fragments, compared to whole antibodies, to detect low concentrations of atrazine and related triazines. The effect of monomeric and dimeric scAb conformations on the ability of enzyme linked immunosorbent assays (ELISAs) to detect atrazine and related triazines is investigated. The thermal and chemical stability of the scAbs, and a modified scAb containing an interchain disulphide bond, are compared with the parent monoclonal antibodies (MAbs) to determine their suitability in an environmental ELISA assay system. The expressions in Escherichia coli (E. coli) of two different anti-atrazine scAbs and related antibody fragments are studied, and an optimised expression protocol for these antibody fragments obtained. Three potentially toxic amino acid residues identified in one of the variable heavy (VH) domains (Knappik & Pluckthun, 1995) are mutated to less toxic amino acids, and their effects on antibody fragment expression observed.

Published
1997

176. Reactivity-Guided Isolation and Medicinal Chemistry of Marine Bacterial Natural Products

Author

Seiler, Grant Steven

Subjects
Organic chemistry
Abstract

Marine natural products have long served as leads for pharmaceutical compounds, as well as sources of compounds whose value lies in the novelty of their structures. As more natural products are discovered and described, compounds with truly novel structures or bioactivities have become increasingly difficult to find. Therefore, a reactivity-guided approach has been developed to aid in the search for natural products bearing specific functional groups. An azide-based probe for terminal alkyne-bearing natural products was synthesized and implemented, which facilitated the discovery of the vatiamide family of natural products. Further, a suite of tetrazine-based probes for isonitrile-bearing natural products was synthesized and evaluated on the basis of reactivity, stability, and fragmentation behavior in mass spectrometry.The marine bacterial natural product lymphostin was recognizable for its unusual structural features, but its biochemical activity, and mechanism thereof, was not fully understood. Lymphostin and its family of related analogs were evaluated for their kinase inhibition activity, and model systems were synthesized to understand lymphostin’s mechanism of kinase inhibition. Lymphostin was found to be a potent and irreversible inhibitor of PI3K/mTOR, the first compound from bacteria to be shown with this activity. An effort towards the total synthesis of lymphostin was then undertaken, resulting in the discovery of an unusual heteroaryl dimerization reaction.

Published
2019

179. A new color-changing species of Corydoras (Siluriformes: Callichthyidae) from the rio Jutaí, Brazilian Amazon.

Author

Caserta Tencatt, Luiz Fernando, Grant, Steven, and Frances Bentley, Rebecca

Subjects
*CATFISHES, *SPECIES, *ORBITS (Astronomy), *BLOOD platelets, *CHROMATOPHORES, *APOSEMATISM, *FISH anatomy
Abstract

A new species of Corydoras is described from the rio Jutaí, Amazon basin, Brazil. The new species can be distinguished from its congeners by having the following features: (I) ventral surface of trunk entirely or almost entirely covered by smallto relatively large-sized coalescent platelets, forming a typical mosaic-like pattern; (II) large, arched dark brown or black patch extending from interopercle region to posterior process of parieto-supraoccipital, transversally crossing the orbit and forming a typical mask-like blotch; (III) absence of conspicuous dark markings on caudal fin; (IV) absence of longitudinal rows of dark blotches on flanks; (V) region of first dorsolateral body plate surrounding posterior process of parieto-supraoccipital clearly lighter than remaining portions of head, forming a V-shaped pattern in dorsal view; (VI) anterior portion of dorsal fin with a conspicuous dark patch; and (VII) anterior portion of dorsal-fin base with conspicuous concentration of dark brown or black chromatophores, forming a dark patch slightly darker than ground color of body. A discussion on the possible positive adaptive value of the color pattern is also provided. [ABSTRACT FROM AUTHOR]

Published
2023
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180. Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells.

Author

Li, Lin, Hu, Xiaoyan, Nkwocha, Jewel, Sharma, Kanika, Kmieciak, Maciej, Mann, Hashim, Zhou, Liang, and Grant, Steven

Subjects
STAT proteins, MULTIPLE myeloma, WNT signal transduction, CELL death, CELL lines, SOCIAL interaction
Abstract

Purpose: The goal of this study was to characterize the relationship between ATR and STAT3 interactions in human multiple myeloma (MM) cells. Methods: Various MM cell lines, including IL-6-dependent cells were exposed to ATR inhibitors and effects on STAT3 Tyr705 and Ser727 were monitored by WB analysis and ImageStream analysis. Parallel studies examined induction of cell death, STAT3 DNA binding activity, and expression of STAT3 downstream targets (BCL-XL, MCL-1, c-MYC). Validation was obtained in ATR shRNA knock-down cells, and in cells ectopically expressing BCL-XL, MCL-1, or c-MYC. Analogous studies were performed in primary MM cells and in a MM xenograft model. Results: Multiple pharmacologic ATR inhibitors inhibited STAT3 Tyr705 (but not Ser727) phosphorylation at low uM concentrations and down-regulated BCL-XL, MCL-1, c-MYC in association with cell death induction. Compatible results were observed in ATR shRNA knock-down cells. Cell death induced by ATR inhibitors was significantly attenuated in cells ectopically expressing constitutively active STAT3, BCL-XL, MCL-1, or c-MYC. Concordant results were observed in primary human MM cells and in an in vivo MM xenograft model. Conclusions: Collectively, these findings argue for a non-canonical role for the ATR kinase in STAT3 activation in MM cells, and suggest that STAT3 inactivation contributes to the lethal actions of ATR inhibitors in MM. [ABSTRACT FROM AUTHOR]

Published
2023
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181. Venetoclax with decitabine or azacitidine in the first‐line treatment of acute myeloid leukemia

Author

Bouligny, Ian M., primary, Murray, Graeme, additional, Doyel, Michael, additional, Patel, Tilak, additional, Boron, Josh, additional, Tran, Valerie, additional, Gor, Juhi, additional, Hang, Yiwei, additional, Alnimer, Yanal, additional, Zacholski, Kyle, additional, Venn, Chad, additional, Wages, Nolan A., additional, Grant, Steven, additional, and Maher, Keri R., additional

Published
2023
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182. Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: Clinical efficacy and correlative analyses

Author

Konopleva, Marina, primary, DiNardo, Courtney, additional, Bhagat, Tushar, additional, Baran, Natalia, additional, Lodi, Alessia, additional, Saxena, Kapil, additional, Cai, Tianyu, additional, Su, Xiaoping, additional, Skwarska, Anna, additional, Guerra, Veronica, additional, Kuruvilla, Vinitha, additional, Konoplev, Sergej, additional, Gordon-Mitchell, Shanisha, additional, Pradhan, Kith, additional, Aluri, Srinivas, additional, Collins, Meghan, additional, Sweeney, Shannon, additional, Busquet, Jonathan, additional, Rathore, Atul, additional, Deng, Qing, additional, Green, Michael, additional, Grant, Steven, additional, Demo, Susan, additional, Choudhary, Gaurav, additional, Sahu, Srabani, additional, Agarwal, Beamon, additional, Spodek, Mason, additional, Thiruthuvanathan, Victor, additional, Will, Britta, additional, Steidl, Ulrich, additional, Tippett, George, additional, Burger, Jan, additional, Borthakur, Gautam, additional, Jabbour, Elias, additional, Pemmaraju, Naveen, additional, Kadia, Tapan, additional, Kornblau, Steven, additional, Daver, Naval, additional, Naqvi, Kiran, additional, Short, Nicholas, additional, Garcia-Manero, Guillermo, additional, Tiziani, Stefano, additional, and Verma, Amit, additional

Published
2023
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193. Randomized Phase II Study to Assess the Role of Nivolumab As Single Agent to Eliminate Minimal Residual Disease and Maintain Remission in Acute Myelogenous Leukemia (AML) Patients after Chemotherapy (NCI9706 protocol; REMAIN Trial)

Author

Liu, Hongtao, primary, Sharon, Elad, additional, Karrison, Theodore G., additional, Zha, Yuanyuan, additional, Fulton, Noreen, additional, Streicher, Howard, additional, Sweet, Kendra, additional, Yaghmour, George, additional, Liu, Jane Jijun, additional, Jonas, Brian A., additional, Schimmer, Aaron D., additional, Grant, Steven, additional, Zeidan, Amer M., additional, Hildebrandt, Gerhard C., additional, Hourigan, Christopher S., additional, Lowrey, Christopher H., additional, Mattison, Ryan J., additional, Palmisiano, Neil, additional, Salhotra, Amandeep, additional, Tzachanis, Dimitrios, additional, Baer, Maria R., additional, Lin, Tara L., additional, Patel, Prapti, additional, Chen, Helen, additional, Stadler, Walter M., additional, Odenike, Olatoyosi, additional, Larson, Richard A., additional, Gajewski, Thomas F., additional, and Stock, Wendy, additional

Published
2022
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