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2,489 results on '"Higgins, James"'

162. Multimodal Neural and Behavioral Data Predict Response to Rehabilitation in Chronic Poststroke Aphasia

Author

Billot, Anne, primary, Lai, Sha, additional, Varkanitsa, Maria, additional, Braun, Emily J., additional, Rapp, Brenda, additional, Parrish, Todd B., additional, Higgins, James, additional, Kurani, Ajay S., additional, Caplan, David, additional, Thompson, Cynthia K., additional, Ishwar, Prakash, additional, Betke, Margrit, additional, and Kiran, Swathi, additional

Published
2022
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169. Conducting robust ecological analyses with climate data

Author

Suggitt, Andrew J., Platts, Philip J., Barata, Izabela M., Bennie, Jonathan J., Burgess, Malcolm D., Bystriakova, Nadia, Duffield, Simon, Ewing, Steven R., Gillingham, Phillipa K., Harper, Anna B., Hartley, Andrew J., Hemming, Deborah L., Maclean, Ilya M. D., Maltby, Katherine, Marshall, Harry H., Morecroft, Mike D., Pearce‐Higgins, James W., Pearce‐Kelly, Paul, Phillimore, Albert B., Price, Jeff T., Pyke, Ayesha, Stewart, James E., Warren, Rachel, and Hill, Jane K.

Published
2017
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171. Identification, characterization, and rescue of CRISPR/Cas9 generated wheat SPO11‐1 mutants.

Author

Hyde, Lucy, Osman, Kim, Winfield, Mark, Sanchez‐Moran, Eugenio, Higgins, James D., Henderson, Ian R., Sparks, Caroline, Franklin, F. Chris H., and Edwards, Keith J.

Subjects
CRISPRS, DOUBLE-strand DNA breaks, HOMOLOGOUS chromosomes, WHEAT, PLANT breeding
Abstract

Summary: Increasing crop yields through plant breeding is time consuming and laborious, with the generation of novel combinations of alleles being limited by chromosomal linkage blocks and linkage‐drag. Meiotic recombination is essential to create novel genetic variation via the reshuffling of parental alleles. The exchange of genetic information between homologous chromosomes occurs at crossover (CO) sites but CO frequency is often low and unevenly distributed. This bias creates the problem of linkage‐drag in recombination 'cold' regions, where undesirable variation remains linked to useful traits. In plants, programmed meiosis‐specific DNA double‐strand breaks, catalysed by the SPO11 complex, initiate the recombination pathway, although only ~5% result in the formation of COs. To study the role of SPO11‐1 in wheat meiosis, and as a prelude to manipulation, we used CRISPR/Cas9 to generate edits in all three SPO11‐1 homoeologues of hexaploid wheat. Characterization of progeny lines shows plants deficient in all six SPO11‐1 copies fail to undergo chromosome synapsis, lack COs and are sterile. In contrast, lines carrying a single copy of any one of the three wild‐type homoeologues are phenotypically indistinguishable from unedited plants both in terms of vegetative growth and fertility. However, cytogenetic analysis of the edited plants suggests that homoeologues differ in their ability to generate COs and in the dynamics of synapsis. In addition, we show that the transformation of wheat mutants carrying six edited copies of SPO11‐1 with the TaSPO11‐1B gene, restores synapsis, CO formation, and fertility and hence opens a route to modifying recombination in this agronomically important crop. [ABSTRACT FROM AUTHOR]

Published
2023
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182. Phenological sensitivity to climate across taxa and trophic levels

Author

Thackeray, Stephen J., Henrys, Peter A., Hemming, Deborah, Bell, James R., Botham, Marc S., Burthe, Sarah, Helaouet, Pierre, Johns, David G., Jones, Ian D., Leech, David I., Mackay, Eleanor B., Massimino, Dario, Atkinson, Sian, Bacon, Philip J., Brereton, Tom M., Carvalho, Laurence, Clutton-Brock, Tim H., Duck, Callan, Edwards, Martin, Elliott, J. Malcolm, Hall, Stephen J.G., Harrington, Richard, Pearce-Higgins, James W., Hoye, Toke T., Kruuk, Loeske E.B., Pemberton, Josephine M., Sparks, Tim H., Thompson, Paul M., White, Ian, Winfield, Ian J., and Wanless, Sarah

Subjects
Phenetics -- Analysis, Biology -- Identification and classification, Ecosystems -- Analysis, Trophic levels -- Analysis, Climate sensitivity -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Differences in phenological responses to climate change among species can desynchronise ecological interactions and thereby threaten ecosystem function. To assess these threats, we must quantify the relative impact of climate change on species at different trophic levels. Here, we apply a Climate Sensitivity Profile approach to 10,003 terrestrial and aquatic phenological data sets, spatially matched to temperature and precipitation data, to quantify variation in climate sensitivity. The direction, magnitude and timing of climate sensitivity varied markedly among organisms within taxonomic and trophic groups. Despite this variability, we detected systematic variation in the direction and magnitude of phenological climate sensitivity. Secondary consumers showed consistently lower climate sensitivity than other groups. We used mid-century climate change projections to estimate that the timing of phenological events could change more for primary consumers than for species in other trophic levels (6.2 versus 2.5-2.9 days earlier on average), with substantial taxonomic variation (1.1-14.8 days earlier on average)., Numerous long-term ecological changes have been attributed to climate change (1). Shifts in the seasonal timing of recurring biological events such as reproduction and migration (that is, phenological changes) have [...]

Published
2016
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195. Resúmenes de los artículos

Author

Bravo Guerreira, M.ª Concepción, Hampe Martínez, Teodoro, Pease, Franklin, Sempat Assadourian, Carlos, Iwasaki, Fernando, Dargent Chamot, Eduardo, de la Puente Brunke, José, Saignes, Tierry, Cañedo-Argüelles Fábrega, Teresa, Bradley, Peter T., Lohmann Villena, Guillermo, Cisneros, Luis Jaime, Guibovich, Pedro, Brown, Kendall W., Fernádez Alonso, Serena, Fisher, John, Medrano, Jose Miguel, Malamud, Carlos, García Vera, José Antonio, Cahill, David P., Rieu-Millán, Marie-Laure, Contreras, Carlos, Miller, Rory, Taylor, Lewis, Higgins, James, and González, Ignacio

Published
2022
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198. Protected areas facilitate species' range expansions

Author

Thomas, Chris D., Gillingham, Phillipa K., Bradbury, Richard B., Roy, David B., Anderson, Barbara J., Baxter, John M., Bourn, Nigel A. D., Crick, Humphrey Q. P., Findon, Richard A., Fox, Richard, Hodgson, Jenny A., Holt, Alison R., Morecroft, Mike D., O'Hanlon, Nina J., Oliver, Tom H., Pearce-Higgins, James W., Procter, Deborah A., Thomas, Jeremy A., Walker, Kevin J., Walmsley, Clive A., Wilson, Robert J., and Hill, Jane K.

Published
2012

199. Creating a Quality Assurance System for Croatian Higher Education

Author

Currie, David M., Krbec, Denisa, and Higgins, James

Abstract

This article presents an action plan for establishing a system of quality assurance for Croatian higher education. The action plan is forward-looking rather than retrospective and draws on experiences with adopting continuous improvement practices in Australia, Turkey, and the United States. Numerous authors have explored the challenges facing Croatian higher education, so we do not duplicate that task. We propose to adopt a continuous improvement system which will help modernize the system of education in Croatia.

Published
2005

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