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151. sj-docx-2-cpa-10.1177_07067437221094552 - Supplemental material for SARS-CoV-2 Infection and the Risk of Suicidal and Self-Harm Thoughts and Behaviour: A Systematic Review

Author

Sinyor, Mark, Zaheer, Rabia, Webb, Roger T., Knipe, Duleeka, Eyles, Emily, Higgins, Julian P.T., McGuinness, Luke, Schmidt, Lena, Macleod-Hall, Catherine, Dekel, Dana, Gunnell, David, and John, Ann

Subjects
FOS: Psychology, FOS: Clinical medicine, 170199 Psychology not elsewhere classified, 110319 Psychiatry (incl. Psychotherapy)
Abstract

Supplemental material, sj-docx-2-cpa-10.1177_07067437221094552 for SARS-CoV-2 Infection and the Risk of Suicidal and Self-Harm Thoughts and Behaviour: A Systematic Review by Mark Sinyor, Rabia Zaheer, Roger T. Webb, Duleeka Knipe, Emily Eyles, Julian P.T. Higgins, Luke McGuinness, Lena Schmidt, Catherine Macleod-Hall, Dana Dekel, David Gunnell and Ann John in The Canadian Journal of Psychiatry

Published
2022
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154. Stakeholder opinions on the structure and development of a new risk of bias tool to assess systematic reviews with network meta-analysis (RoB NMA tool): a cross-sectional survey

Author

Lunny, Carole, primary, Veroniki, Areti Angeliki, additional, Hutton, Brian, additional, White, Ian R, additional, Higgins, Julian PT, additional, Wright, James M, additional, Kim, Ji Yoon, additional, Thirugnanasampanthar, Sai Surabi, additional, Siddiqui, Shazia, additional, Moja, Lorenzo, additional, Taske, Nichole, additional, Lorenz, Robert, additional, Gerrish, Savannah, additional, Straus, Sharon, additional, Minogue, Virginia, additional, Hu, Franklin, additional, Kapani, Ayah, additional, Nagi, Samin, additional, Chen, Lillian, additional, Akbar-nejad, Mona, additional, and Tricco, Andrea C., additional

Published
2022
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155. The impact of the COVID-19 pandemic on health service utilisation following self-harm: a systematic review

Author

Steeg, Sarah, primary, John, Ann, additional, Gunnell, David, additional, Kapur, Nav, additional, Dekel, Dana, additional, Schmidt, Lena, additional, Knipe, Duleeka, additional, Arensman, Ella, additional, Hawton, Keith, additional, Higgins, Julian PT, additional, Eyles, Emily, additional, Macleod-Hall, Catherine, additional, McGuiness, Luke A, additional, and Webb, Roger T, additional

Published
2022
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156. Meta-analysis of chemotherapy in nasopharynx carcinoma (MAC-NPC): An update on 26 trials and 7080 patients

Author

Blanchard, Pierre, primary, Lee, Anne W.M., additional, Carmel, Alexandra, additional, Wai Tong, Ng, additional, Ma, Jun, additional, Chan, Anthony T.C., additional, Hong, Ruey Long, additional, Chen, Ming-Yuan, additional, Chen, Lei, additional, Li, Wen-Fei, additional, Huang, Pei-Yu, additional, Kwong, Dora L.W., additional, Poh, Sharon S.X., additional, Ngan, Roger, additional, Mai, Hai-Qiang, additional, Ollivier, Camille, additional, Fountzilas, George, additional, Zhang, Li, additional, Bourhis, Jean, additional, Aupérin, Anne, additional, Lacas, Benjamin, additional, Pignon, Jean-Pierre, additional, Blanchard, Pierre, additional, Benhamou, Ellen, additional, Chakrabandhu, Somvilai, additional, TC Chan, Anthony, additional, Chen, Qiu-Yan, additional, Chen, Yong, additional, Chappell, Richard J, additional, Choi, Horace, additional, TT Chua, Daniel, additional, Lee Kiang Chua, Melvin, additional, Higgins, Julian, additional, Hong, Ming-Huang, additional, Hong, Ruey-Long, additional, Pun Hui, Edwin, additional, Hsiao, C.F., additional, Kam, Michael, additional, Angeliki Koliou, Georgia, additional, LW Kwong, Dora, additional, Lai, Shu-Chuan, additional, On Lam, Ka, additional, LeBlanc, Michael L, additional, WM Lee, Anne, additional, Fun Victor Lee, Ho, additional, Fei Li, Wen, additional, Ma, Brigette, additional, Mo, Frankie, additional, Moon, James, additional, Tong Ng, Wai, additional, O'Sullivan, Brian, additional, Petit, Claire, additional, Pierre Pignon, Jean, additional, Poh, Sharon X., additional, Rücker, Gerta, additional, Sham, Jonathan, additional, Lim Soong, Yoke, additional, Sun, Ying, additional, Tan, Terence, additional, Tang, Lin-Quan, additional, Tung, Yuk, additional, Wee, Joseph, additional, Wu, Xuang, additional, Xu, Tingting, additional, Zhang, Yuan, additional, and Zhu, Guopei, additional

Published
2022
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159. Systematic review of the impact of the COVID-19 pandemic on suicidal behaviour amongst health and social care workers across the world

Author

Eyles, Emily, primary, Moran, Paul, additional, Okolie, Chukwudi, additional, Dekel, Dana, additional, Macleod-Hall, Catherine, additional, Webb, Roger T., additional, Schmidt, Lena, additional, Knipe, Duleeka, additional, Sinyor, Mark, additional, McGuinness, Luke A., additional, Arensman, Ella, additional, Hawton, Keith, additional, O'Connor, Rory C., additional, Kapur, Nav, additional, O'Neill, Siobhan, additional, Olorisade, Babatunde, additional, Cheng, Hung-Yuan, additional, Higgins, Julian P.T., additional, John, Ann, additional, and Gunnell, David, additional

Published
2021
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163. Strengthening the reporting of genetic association studies (STREGA)—an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement

Author

Little, Julian, Higgins, Julian P.T., Ioannidis, John P.A., Moher, David, Gagnon, France, von Elm, Erik, Khoury, Muin J., Cohen, Barbara, Davey-Smith, George, Grimshaw, Jeremy, Scheet, Paul, Gwinn, Marta, Williamson, Robin E., Zou, Guang Yong, Hutchings, Kim, Johnson, Candice Y., Tait, Valerie, Wiens, Miriam, Golding, Jean, van Duijn, Cornelia, McLaughlin, John, Paterson, Andrew, Wells, George, Fortier, Isabel, Freedman, Matthew, Zecevic, Maja, King, Richard, Infante-Rivard, Claire, Stewart, Alex F., and Birkett, Nick

Published
2009
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165. Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review.

Author

Spiga, Francesca, Gibson, Mark, Dawson, Sarah, Tilling, Kate, Smith, George Davey, Munafò, Marcus R, and Higgins, Julian P T

Subjects
INSTRUMENTAL variables (Statistics), RANDOMIZATION (Statistics), ACQUISITION of data, PREPRINTS, MEDLINE
Abstract

Background The use of Mendelian randomization (MR) in epidemiology has increased considerably in recent years, with a subsequent increase in systematic reviews of MR studies. We conducted a systematic review of tools designed for assessing risk of bias and/or quality of evidence in MR studies and a review of systematic reviews of MR studies. Methods We systematically searched MEDLINE, Embase, the Web of Science, preprints servers and Google Scholar for articles containing tools for assessing, conducting and/or reporting MR studies. We also searched for systematic reviews and protocols of systematic reviews of MR studies. From eligible articles we collected data on tool characteristics and content, as well as details of narrative description of bias assessment. Results Our searches retrieved 2464 records to screen, from which 14 tools, 35 systematic reviews and 38 protocols were included in our review. Seven tools were designed for assessing risk of bias/quality of evidence in MR studies and evaluation of their content revealed that all seven tools addressed the three core assumptions of instrumental variable analysis, violation of which can potentially introduce bias in MR analysis estimates. Conclusion We present an overview of tools and methods to assess risk of bias/quality of evidence in MR analysis. Issues commonly addressed relate to the three standard assumptions of instrumental variables analyses, the choice of genetic instrument(s) and features of the population(s) from which the data are collected (particularly in two-sample MR), in addition to more traditional non-MR-specific epidemiological biases. The identified tools should be tested and validated for general use before recommendations can be made on their widespread use. Our findings should raise awareness about the importance of bias related to MR analysis and provide information that is useful for assessment of MR studies in the context of systematic reviews. [ABSTRACT FROM AUTHOR]

Published
2023
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167. Prevalence of BRAFV600 in glioma and use of BRAF Inhibitors in patients with BRAFV600 mutation-positive glioma: systematic review

Author

Andrews, Lily J, primary, Thornton, Zak A, additional, Saincher, Saanwalshah S, additional, Yao, Ian Y, additional, Dawson, Sarah, additional, McGuinness, Luke A, additional, Jones, Hayley E, additional, Jefferies, Sarah, additional, Short, Susan C, additional, Cheng, Hung-Yuan, additional, McAleenan, Alexandra, additional, Higgins, Julian P T, additional, and Kurian, Kathreena M, additional

Published
2021
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168. Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization

Author

Skrivankova, Veronika W., primary, Richmond, Rebecca C., additional, Woolf, Benjamin A. R., additional, Yarmolinsky, James, additional, Davies, Neil M., additional, Swanson, Sonja A., additional, VanderWeele, Tyler J., additional, Higgins, Julian P. T., additional, Timpson, Nicholas J., additional, Dimou, Niki, additional, Langenberg, Claudia, additional, Golub, Robert M., additional, Loder, Elizabeth W., additional, Gallo, Valentina, additional, Tybjaerg-Hansen, Anne, additional, Davey Smith, George, additional, Egger, Matthias, additional, and Richards, J. Brent, additional

Published
2021
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172. Investigating the transparency of reporting in two-sample summary data Mendelian randomization studies

Author

Woolf, Benjamin, primary, Cara, Nina Di, additional, Moreno-Stokoe, Christopher, additional, Skrivankova, Veronika, additional, Drax, Katie, additional, Higgins, Julian P.T., additional, Hemani, Gibran, additional, Munafò, Marcus R., additional, Smith, George Davey, additional, Yarmolinsky, James, additional, and Richmond, Rebecca C., additional

Published
2021
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176. Suicide and self-harm in low- and middle- income countries during the COVID-19 pandemic: A systematic review

Author

Knipe, Duleeka, primary, John, Ann, additional, Padmanathan, Prianka, additional, Eyles, Emily, additional, Dekel, Dana, additional, Higgins, Julian PT, additional, Bantjes, Jason, additional, Dandona, Rakhi, additional, Macleod-Hall, Catherine, additional, McGuinness, Luke A, additional, Schmidt, Lena, additional, Webb, Roger T, additional, and Gunnell, David, additional

Published
2021
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179. Detecting Heterogeneity of Intervention Effects Using Analysis and Meta-analysis of Differences in Variance Between Trial Arms.

Author

Mills, Harriet L., Higgins, Julian P.T., Morris, Richard W., Kessler, David, Heron, Jon, Wiles, Nicola, Davey Smith, George, Tilling, Kate, and Higgins, Julian Pt

Abstract

Background: Randomized controlled trials (RCTs) with continuous outcomes usually only examine mean differences in response between trial arms. If the intervention has heterogeneous effects, then outcome variances will also differ between arms. Power of an individual trial to assess heterogeneity is lower than the power to detect the same size of main effect.Methods: We describe several methods for assessing differences in variance in trial arms and apply them to a single trial with individual patient data and to meta-analyses using summary data. Where individual data are available, we use regression-based methods to examine the effects of covariates on variation. We present an additional method to meta-analyze differences in variances with summary data.Results: In the single trial, there was agreement between methods, and the difference in variance was largely due to differences in prevalence of depression at baseline. In two meta-analyses, most individual trials did not show strong evidence of a difference in variance between arms, with wide confidence intervals. However, both meta-analyses showed evidence of greater variance in the control arm, and in one example, this was perhaps because mean outcome in the control arm was higher.Conclusions: Using meta-analysis, we overcame low power of individual trials to examine differences in variance using meta-analysis. Evidence of differences in variance should be followed up to identify potential effect modifiers and explore other possible causes such as varying compliance. [ABSTRACT FROM AUTHOR]

Published
2021
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184. Systematic reviews of genetic association studies

Author

Sagoo, Gurdeep S., Little, Julian, and Higgins, Julian P. T.

Subjects
Usage, Research, Genotypes -- Usage -- Research, Genetic disorders -- Research, Genotype -- Usage -- Research
Abstract

The past decade has witnessed growing interest in genetic predisposition to common diseases, and along with rapid advancements in high-throughput genotyping technology, has resulted in a tremendous amount of published [...]

Published
2009

185. Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19 : a meta-analysis

Author

The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group, [missing], Domingo, Pere, Mur, Isabel, Mateo, Gracia María, Gutierrez, Maria del Mar, Pomar, Virginia, de Benito, Natividad, Corbacho, Noemí, Herrera, Silvia, Millan, Lucia, Muñoz, Jessica, Malouf, Jorge, Molas, Maria Ema, Asensi, Victor, Horcajada, Juan Pablo, Estrada, Vicente, Gutierrez, Felix, Torres, Ferran, Perez-Molina, Jose A, Fortun, Jesús, Villar, Luisa M, Hohenthal, Ulla, Marttila, Harri, Vuorinen, Tytti, Nordberg, Marika, Valtonen, Mika, Frigault, Matthew J, Mansour, Michael K, Patel, Naomi J, Fernandes, Ana, Harvey, Liam, Foulkes, Andrea S, Healy, Brian C, Shah, Ruta, Bensaci, Ana Maria, Woolley, Ann E., Nikiforow, Sarah, Lin, Nina, Sagar, Manish, Shrager, Harry, Huckins, David S., Axelrod, Matthew, Pincus, Michael D, Fleisher, Jorge, Lampa, Jon, Nowak, Piotr, Vesterbacka, Jan C., Rasmuson, Johan, Skorup, Paul, Janols, Helena, Niward, Katarina F, Chatzidionysiou, Katerina, Asgeirsson, Hilmir, Parke, Åsa, Blennow, Ola, Svensson, Anna-Karin, Aleman, Soo, Sönnerborg, Anders, Henter, Jan-Inge, Horne, Anna Carin, Al-Beidh, Farah, Angus, Derek, Annane, Djillali, Arabi, Yaseen, Beane, Abigail, Berry, Scott, Bhimani, Zahra, Bonten, Marc, Bradbury, Charlotte, Brunkhorst, Frank, Buxton, Meredith, Cheng, Allen, Cove, Matt, De Jong, Menno, Derde, Lennie, Estcourt, Lise, Goossens, Herman, Gordon, Anthony, Green, Cameron, Haniffa, Rashan, Ichihara, Nao, Lamontagne, Francois, Lawler, Patrick, Litton, Ed, Marshall, John, McArthur, Colin, McAuley, Daniel, McGuinness, Shay, McVerry, Bryan, Montgommery, Stephanie, Mouncey, Paul, Murthy, Srinivas, Nichol, Alistair, Parke, Rachael, Parker, Jane, Reyes, Felipe, Rowan, Kathryn, Saito, Hiroki, Santos, Marlene, Seymour, Chris, Shankar-Hari, Manu, Turgeon, Alexis, Turner, Anne, van Bentum-Puijk, Wilma, van de Veerdonk, Frank, Webb, Steve, Zarychanski, Ryan, Baillie, J Kenneth, Beasley, Richard, Cooper, Nichola, Fowler, Robert, Galea, James, Hills, Thomas, King, Andrew, Morpeth, Susan, Netea, Mihai, Ogungbenro, Kayode, Pettila, Ville, Tong, Steve, Uyeki, Tim, Youngstein, Taryn, Higgins, Alisa, Lorenzi, Elizabeth, Berry, Lindsay, Salama, Carlos, Rosas, Ivan O., Ruiz-Antorán, Belén, Muñez Rubio, Elena, Ramos Martínez, Antonio, Campos Esteban, José, Avendaño Solá, Cristina, Pizov, Reuven, Sanz Sanz, Jesus, Abad-Santos, Francisco, Bautista-Hernández, Azucena, García-Fraile, Lucio, Barrios, Ana, Gutiérrez Liarte, Ángela, Alonso Pérez, Tamara, Rodríguez-García, Sebastian C, Mejía-Abril, Gina, Prieto, Jose Carlos, Leon, Rafael, VEIGA, VIVIANE C., SCHEINBERG, PHILLIP, FARIAS, DANIELLE L.C., PRATS, JOÃO G., CAVALCANTI, ALEXANDRE B., MACHADO, FLAVIA R., ROSA, REGIS G., BERWANGER, OTÁVIO, AZEVEDO, LUCIANO C.P., LOPES, RENATO D., DOURADO, LETICIA K., CASTRO, CLAUDIO G., ZAMPIERI, FERNANDO G., AVEZUM, ALVARO, LISBOA, THIAGO C., ROJAS, SALOMÓN S.O., COELHO, JULIANA C., LEITE, RODRIGO T., CARVALHO, JULIO CESAR, ANDRADE, LUIS E.C., SANDES, ALEX R., PINTÃO, MARIA CAROLINA T., SANTOS, SUELI V., ALMEIDA, THIAGO M.L., COSTA, ANDRÉ N., GEBARA, OTAVIO C.E., FREITAS, FLAVIO G.R., PACHECO, EDUARDO S., MACHADO, DAVID J.B., MARTIN, JOSIANE, CONCEIÇÃO, FABIO G., SIQUEIRA, SUELLEN R.R., DAMIANI, LUCAS P., ISHIHARA, LUCIANA M., SCHNEIDER, DANIEL, DE SOUZA, DENISE, Hermine, Olivier, Mariette, Xavier, Tharaux, Pierre Louis, Resche Rigon, Matthieu, Porcher, Raphael, Ravaud, Philippe, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Tibi, Annick, Yazdanpanah, Yazdan, Dougados, Maxime, Bureau, Serge, Horby, Peter W, Landray, Martin J, Baillie, Kenneth J, Buch, Maya H, Chappell, Lucy C, Day, Jeremy N, Faust, Saul N, Haynes, Richard, Jaki, Thomas, Jeffery, Katie, Juszczak, Edmund, Lim, Wei Shen, Mafham, Marion, Montgomery, Alan, Mumford, Andrew, Thwaites, Guy, Kamarulzaman, Adeeba, Syed Omar, Sharifah Faridah, Ponnampalavanar, Sasheela, Raja Azwa, Raja Iskandar Syah, Wong, Pui Li, Kukreja, Anjanna, Ong, Hang Cheng, Sulaiman, Helmi, Basri, Sazali, Ng, Rong Xiang, Megat Johari, Bushra, Rajasuriar, Reena, Chong, Meng Li, Neelamegam, Malinee, Syed Mansor, Syed Mukhtar, Zulhaimi, Nurul Syuhada, Lee, Cheng Siang, Altice, Frederick, Price, Christina, Malinis, Maricar, Hasan, Mohd Shahnaz, Wong, Chee Kuan, Chidambaram, Suresh, Misnan, Nor Arisah, Mohd Thabit, Alif Adlan, Sim, Benedict, Bidin, Farah Nadiah, Mohd Abd Rahim, Mohd Abd Hafiz, Saravanamuttu, Sujana, Tuang, Wei Xuan, Mohamed Gani, Yasmin, Thangavelu, Suvintheran, Tay, Kim Heng, Ibrahim, Nur Munirah, Halid, Luqman Alhakim, Tan, Kok Tong, Mukri, Mohd Noor Azreet, Arip, Masita, Koh, Hui Moon, Syed Badaruddin, Syarifah Nurul Ain, Raja Sureja, Letchumi, Chun, Geok Ying, TORRE-CISNEROS, JULIAN, MERCHANTE, NICOLAS, LEON, RAFAEL, CARCEL, SHEILA, GARRIDO, JOSE CARLOS, Galun, Eitan, Soriano, Alex, Martínez, José Antonio, Castán, Clara, Paredes, Roger, Dalmau, David, Carbonell, Cristina, Espinosa, Gerard, Castro, Pedro, Muñóz, José, Almuedo, Alex, Prieto, Sergio, Pacheco, Iván, Ratain, Mark, Pisano, Jennifer, Strek, Mary, Adegunsoye, Ayodeji, Karrison, Theodore, Declercq, Jozefien, Van Damme, Karel, De Leeuw, Elisabeth, Bosteels, Cedric, Maes, Bastiaan, Vale, Claire L., Godolphin, Peter J., Fisher, David, Higgins, Julian P. T., Spiga, Francesca, Savovic, Jelena, Tierney, Jayne, Baron, Gabriel, Benbenishty, Julie S., Berry, Lindsay R., Broman, Niklas, Cavalcanti, Alexandre Biasi, Colman, Roos, De Buyser, Stefanie, Derde, Lennie P. G., Omar, Sharifah Faridah, Fernandez-Cruz, Ana, Feuth, Thijs, Garcia, Felipe, Garcia-Vicuna, Rosario, Gonzalez-Alvaro, Isidoro, Gordon, Anthony C., Horby, Peter W., Horick, Nora K., Kumar, Kuldeep, Lambrecht, Bart, Landray, Martin J., Leal, Lorna, Lederer, David J., Merchante, Nicolas, Mohan, Shalini V., Nivens, Michael C., Oksi, Jarmo, Perez-Molina, Jose A., Postma, Simone, Ramanan, Athimalaipet V., Reid, Pankti D., Rutgers, Abraham, Sancho-Lopez, Aranzazu, Seto, Todd B., Sivapalasingam, Sumathi, Soin, Arvinder Singh, Staplin, Natalie, Stone, John H., Strohbehn, Garth W., Sunden-Cullberg, Jonas, Torre-Cisneros, Julian, Tsai, Larry W., van Hoogstraten, Hubert, van Meerten, Tom, Veiga, Viviane Cordeiro, Westerweel, Peter E., Diaz, Janet V., Marshall, John C., Sterne, Jonathan A. C., Translational Immunology Groningen (TRIGR), Stem Cell Aging Leukemia and Lymphoma (SALL), World Health Organization, and Group, WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working

Subjects
Male, medicine.medical_specialty, Randomization, Secondary infection, Placebo, Antibodies, Monoclonal, Humanized, Internal medicine, Cause of Death, Medicine and Health Sciences, Medicine, Humans, Prospective Studies, Prospective cohort study, Glucocorticoids, METAANALYSIS, Cause of death, Aged, Randomized Controlled Trials as Topic, business.industry, Coinfection, Interleukin-6, COVID-19, Odds ratio, General Medicine, Middle Aged, Respiration, Artificial, COVID-19 Drug Treatment, Clinical trial, Hospitalization, Meta-analysis, Disease Progression, Drug Therapy, Combination, Female, business
Abstract

[Importance] Clinical trials assessing the efficacy of IL-6 antagonists in patients hospitalized for COVID-19 have variously reported benefit, no effect, and harm., [Objective] To estimate the association between administration of IL-6 antagonists compared with usual care or placebo and 28-day all-cause mortality and other outcomes., [Data Sources] Trials were identified through systematic searches of electronic databases between October 2020 and January 2021. Searches were not restricted by trial status or language. Additional trials were identified through contact with experts., [Study Selection] Eligible trials randomly assigned patients hospitalized for COVID-19 to a group in whom IL-6 antagonists were administered and to a group in whom neither IL-6 antagonists nor any other immunomodulators except corticosteroids were administered. Among 72 potentially eligible trials, 27 (37.5%) met study selection criteria., [Data Extraction and Synthesis] In this prospective meta-analysis, risk of bias was assessed using the Cochrane Risk of Bias Assessment Tool. Inconsistency among trial results was assessed using the I2 statistic. The primary analysis was an inverse variance–weighted fixed-effects meta-analysis of odds ratios (ORs) for 28-day all-cause mortality., [Main Outcomes and Measures] The primary outcome measure was all-cause mortality at 28 days after randomization. There were 9 secondary outcomes including progression to invasive mechanical ventilation or death and risk of secondary infection by 28 days., [Results] A total of 10 930 patients (median age, 61 years [range of medians, 52-68 years]; 3560 [33%] were women) participating in 27 trials were included. By 28 days, there were 1407 deaths among 6449 patients randomized to IL-6 antagonists and 1158 deaths among 4481 patients randomized to usual care or placebo (summary OR, 0.86 [95% CI, 0.79-0.95]; P = .003 based on a fixed-effects meta-analysis). This corresponds to an absolute mortality risk of 22% for IL-6 antagonists compared with an assumed mortality risk of 25% for usual care or placebo. The corresponding summary ORs were 0.83 (95% CI, 0.74-0.92; P, [Conclusions and Relevance] In this prospective meta-analysis of clinical trials of patients hospitalized for COVID-19, administration of IL-6 antagonists, compared with usual care or placebo, was associated with lower 28-day all-cause mortality., [Trial Registration] PROSPERO Identifier: CRD42021230155., Funding for administrative and communications support was provided by the World Health Organization.

Published
2021

186. Additional file 1 of Prevalence of evidence of inconsistency and its association with network structural characteristics in 201 published networks of interventions

Author

Veroniki, Areti Angeliki, Tsokani, Sofia, White, Ian R., Schwarzer, Guido, Rücker, Gerta, Mavridis, Dimitris, Higgins, Julian P. T., and Salanti, Georgia

Abstract

Additional file 1: Appendix 1. Eligibility criteria, screening, study selection, and data abstraction. Appendix 2. Model description. Appendix Figure 1. Flowchart for network meta-analysis study inclusion. Appendix Table 1. Number of consistent and inconsistent networks at 0.05 and 0.10 significance levels using DL and REML heterogeneity estimators. Appendix Table 2. Multivariable regression analysis results. Appendix Figure 2. Stacked bar plot of consistent (green bars) and inconsistent (blue bars) networks at α = 0.05 per heterogeneity estimator and year of study publication‡. Appendix Figure 3. Plot of p-values (fourth-root scale) of the DBT model against network structural characteristics (logarithmic scale). Appendix Figure 4. Plot of p-values (fourth-root scale) of the DBT model against ratios of network structural characteristics (logarithmic scale). Appendix Figure 5. Plot of the between-study standard deviation estimated in the consistency model against the ratio of the number of studies to the number of interventions in a network (logarithmic scale). Appendix Figure 6. Box plot of the p-values (fourth-root scale) of the DBT model per (a) type of outcome, (b) type of intervention comparison, c) presence of complex interventions, and d) presence of at least one direct intervention comparison with a single study. Appendix Figure 7. Plot of the p-values (fourth-root scale) of the DBT model against the I-squared. Appendix Figure 8. Plot of the between-study standard deviation in consistency against the inconsistency model. Appendix Figure 9. Plot of the between-study standard deviation in inconsistency against the degrees of freedom of the Wald chi-square test (logarithmic scale).

Published
2021
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187. Additional file 2 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Subjects
ComputingMethodologies_PATTERNRECOGNITION, TheoryofComputation_ANALYSISOFALGORITHMSANDPROBLEMCOMPLEXITY, Data_FILES, Hardware_CONTROLSTRUCTURESANDMICROPROGRAMMING, MathematicsofComputing_DISCRETEMATHEMATICS
Abstract

Additional file 2. Instructions for filling in the Pairwise Comparisons Table.

Published
2021
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188. Additional file 6 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Abstract

Additional file 6. Contribution matrix for the network of non-invasive diagnostic modalities for coronary artery disease in patients with low risk acute coronary syndrome.

Published
2021
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189. Additional file 3 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Subjects
ComputingMilieux_GENERAL, ComputingMilieux_THECOMPUTINGPROFESSION, Data_FILES, ComputerSystemsOrganization_PROCESSORARCHITECTURES, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION
Abstract

Additional file 3. Instructions for filling in the ROB-MEN Table.

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2021
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190. Additional file 4 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Subjects
psychological phenomena and processes
Abstract

Additional file 4. Description of the judgements from the across-study assessment of bias for the example of non-invasive diagnostic modalities for detection of coronary artery disease in patients with low risk acute coronary syndromes.

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2021
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193. Additional file 5 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Abstract

Additional file 5. Flow chart for assessing overall risk of bias due to missing evidence in pairwise comparisons.

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2021
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194. Additional file 1 of ROB-MEN: a tool to assess risk of bias due to missing evidence in network meta-analysis

Author

Chiocchia, Virginia, Nikolakopoulou, Adriani, Higgins, Julian P. T., Page, Matthew J., Papakonstantinou, Theodoros, Cipriani, Andrea, Furukawa, Toshi A., Siontis, George C. M., Egger, Matthias, and Salanti, Georgia

Abstract

Additional file 1. Network graph, methods and forest plot for the network meta-analysis of non-invasive diagnostic modalities for the detection of coronary artery disease in patients with low risk acute coronary syndromes.

Published
2021
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195. Additional file 1 of The REPRISE project: protocol for an evaluation of REProducibility and Replicability In Syntheses of Evidence

Author

Page, Matthew J., Moher, David, Fidler, Fiona M., Higgins, Julian P. T., Brennan, Sue E., Haddaway, Neal R., Hamilton, Daniel G., Kanukula, Raju, Sathya Karunananthan, Maxwell, Lara J., McDonald, Steve, Nakagawa, Shinichi, Nunan, David, Tugwell, Peter, Welch, Vivian A., and McKenzie, Joanne E.

Subjects
Data_FILES
Abstract

Additional file 1:. Search strategies

Published
2021
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197. The impact of the COVID-19 pandemic on self-harm and suicidal behaviour: update of living systematic review

Author

John, Ann, primary, Eyles, Emily, additional, Webb, Roger T., additional, Okolie, Chukwudi, additional, Schmidt, Lena, additional, Arensman, Ella, additional, Hawton, Keith, additional, O'Connor, Rory C., additional, Kapur, Nav, additional, Moran, Paul, additional, O'Neill, Siobhan, additional, McGuinness, Luke A., additional, Olorisade, Babatunde K., additional, Dekel, Dana, additional, Macleod-Hall, Catherine, additional, Cheng, Hung-Yuan, additional, Higgins, Julian P.T., additional, and Gunnell, David, additional

Published
2021
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198. Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review

Author

Danesh, John, Kaptoge, Stephen, Mann, Andrea G., Sarwar, Nadeem, Wood, Angela, Angleman, Sara B., Wensley, Frances, Higgins, Julian P.T., Lennon, Lucy, Eiriksdottir, Gudny, Rumley, Ann, Whincup, Peter H., Lowe, Gordon D.O., and Gudnason, Vilmundur

Abstract

Introduction As atherosclerosis may be an inflammatory condition [1], there is interest in the relevance of various circulating inflammatory markers to cardiovascular diseases [2]. Inflammatory cascades are propagated by proximal [...], Background The relevance to coronary heart disease (CHD) of cytokines that govern inflammatory cascades, such as interleukin-6 (IL-6), may be underestimated because such mediators are short acting and prone to fluctuations. We evaluated associations of long-term circulating IL-6 levels with CHD risk (defined as nonfatal myocardial infarction [MI] or fatal CHD) in two population-based cohorts, involving serial measurements to enable correction for within-person variability. We updated a systematic review to put the new findings in context. Methods and Findings Measurements were made in samples obtained at baseline from 2,138 patients who had a first-ever nonfatal MI or died of CHD during follow-up, and from 4,267 controls in two cohorts comprising 24,230 participants. Correction for within-person variability was made using data from repeat measurements taken several years apart in several hundred participants. The yearto-year variability of IL-6 values within individuals was relatively high (regression dilution ratios of 0.41, 95% confidence interval [CI] 0.28-0.53, over 4 y, and 0.35, 95% CI 0.23-0.48, over 12 y). Ignoring this variability, we found an odds ratio for CHD, adjusted for several established risk factors, of 1.46 (95% CI 1.29-1.65) per 2 standard deviation (SD) increase of baseline IL-6 values, similar to that for baseline C-reactive protein. After correction for within-person variability, the odds ratio for CHD was 2.14 (95% CI 1.45-3.15) with long-term average ('usual') IL-6, similar to those for some established risk factors. Increasing IL-6 levels were associated with progressively increasing CHD risk. An updated systematic review of electronic databases and other sources identified 15 relevant previous population-based prospective studies of IL-6 and clinical coronary outcomes (i.e., MI or coronary death). Including the two current studies, the 17 available prospective studies gave a combined odds ratio of 1.61 (95% CI 1.42-1.83) per 2 SD increase in baseline IL-6 (corresponding to an odds ratio of 3.34 [95% CI 2.45-4.56] per 2 SD increase in usual [long-term average] IL-6 levels). Conclusions Long-term IL-6 levels are associated with CHD risk about as strongly as are some major established risk factors, but causality remains uncertain. These findings highlight the potential relevance of IL-6-mediated pathways to CHD.

Published
2008

199. Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19

Author

Sterne, Jonathan A. C., Murthy, Srinivas, Diaz, Janet V., Slutsky, Arthur S., Villar, Jesús, Angus, Derek C., Annane, Djillali, Azevedo, Luciano Cesar Pontes, Berwanger, Otavio, Cavalcanti, Alexandre B., Dequin, Pierre-Francois, Du, Bin, Emberson, Jonathan, Fisher, David, Giraudeau, Bruno, Gordon, Anthony C., Granholm, Anders, Green, Cameron, Haynes, Richard, Heming, Nicholas, Higgins, Julian P. T., Horby, Peter, Jüni, Peter, Landray, Martin J., Le Gouge, Amelie, Leclerc, Marie, Lim, Wei Shen, Machado, Flávia R., McArthur, Colin, Meziani, Ferhat, Møller, Morten Hylander, Perner, Anders, Petersen, Marie Warrer, Savovic, Jelena, Tomazini, Bruno, Veiga, Viviane C., Webb, Steve, and Marshall, John C.

Subjects
General Medicine
Published
2020
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200. Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization:The STROBE-MR Statement

Author

Skrivankova, Veronika W., Richmond, Rebecca C., Woolf, Benjamin A.R., Yarmolinsky, James, Davies, Neil M., Swanson, Sonja A., Vanderweele, Tyler J., Higgins, Julian P.T., Timpson, Nicholas J., Dimou, Niki, Langenberg, Claudia, Golub, Robert M., Loder, Elizabeth W., Gallo, Valentina, Tybjaerg-Hansen, Anne, Davey Smith, George, Egger, Matthias, Richards, J. Brent, Skrivankova, Veronika W., Richmond, Rebecca C., Woolf, Benjamin A.R., Yarmolinsky, James, Davies, Neil M., Swanson, Sonja A., Vanderweele, Tyler J., Higgins, Julian P.T., Timpson, Nicholas J., Dimou, Niki, Langenberg, Claudia, Golub, Robert M., Loder, Elizabeth W., Gallo, Valentina, Tybjaerg-Hansen, Anne, Davey Smith, George, Egger, Matthias, and Richards, J. Brent

Abstract

Importance: Mendelian randomization (MR) studies use genetic variation associated with modifiable exposures to assess their possible causal relationship with outcomes and aim to reduce potential bias from confounding and reverse causation. Objective: To develop the STROBE-MR Statement as a stand-alone extension to the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) guideline for the reporting of MR studies. Design, Setting, and Participants: The development of the STROBE-MR Statement followed the Enhancing the Quality and Transparency of Health Research (EQUATOR) framework guidance and used the STROBE Statement as a starting point to draft a checklist tailored to MR studies. The project was initiated in 2018 by reviewing the literature on the reporting of instrumental variable and MR studies. A group of 17 experts, including MR methodologists, MR study design users, developers of previous reporting guidelines, and journal editors, participated in a workshop in May 2019 to define the scope of the Statement and draft the checklist. The draft checklist was published as a preprint in July 2019 and discussed on the preprint platform, in social media, and at the 4th Mendelian Randomization Conference. The checklist was then revised based on comments, further refined through 2020, and finalized in July 2021. Findings: The STROBE-MR checklist is organized into 6 sections (Title and Abstract, Introduction, Methods, Results, Discussion, and Other Information) and includes 20 main items and 30 subitems. It covers both 1-sample and 2-sample MR studies that assess 1 or multiple exposures and outcomes, and addresses MR studies that follow a genome-wide association study and are reported in the same article. The checklist asks authors to justify why MR is a helpful method to address the study question and state prespecified causal hypotheses. The measurement, quality, and selection of genetic variants must be described and attempts to assess validi

Published
2021

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