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151. Modulation of Triple Artemisinin-Based Combination Therapy Pharmacodynamics by Plasmodium falciparum Genotype

Author

Ansbro, Megan R., primary, Itkin, Zina, additional, Chen, Lu, additional, Zahoranszky-Kohalmi, Gergely, additional, Amaratunga, Chanaki, additional, Miotto, Olivo, additional, Peryea, Tyler, additional, Hobbs, Charlotte V., additional, Suon, Seila, additional, Sá, Juliana M., additional, Dondorp, Arjen M., additional, van der Pluijm, Rob W., additional, Wellems, Thomas E., additional, Simeonov, Anton, additional, and Eastman, Richard T., additional

Published
2020
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155. Exome sequencing identifies variants in infants with sacral agenesis.

Author

Pitsava, Georgia, Feldkamp, Marcia L., Pankratz, Nathan, Lane, John, Kay, Denise M., Conway, Kristin M., Hobbs, Charlotte, Shaw, Gary M., Reefhuis, Jennita, Jenkins, Mary M., Almli, Lynn M., Moore, Cynthia, Werler, Martha, Browne, Marilyn L., Cunniff, Chris, Olshan, Andrew F., Pangilinan, Faith, Brody, Lawrence C., Sicko, Robert J., and Finnell, Richard H.

Abstract

Background: Sacral agenesis (SA) consists of partial or complete absence of the caudal end of the spine and often presents with additional birth defects. Several studies have examined gene variants for syndromic forms of SA, but only one has examined exomes of children with non‐syndromic SA. Methods: Using buccal cell specimens from families of children with non‐syndromic SA, exomes of 28 child–parent trios (eight with and 20 without a maternal diagnosis of pregestational diabetes) and two child–father duos (neither with diagnosis of maternal pregestational diabetes) were exome sequenced. Results: Three children had heterozygous missense variants in ID1 (Inhibitor of DNA Binding 1), with CADD scores >20 (top 1% of deleterious variants in the genome); two children inherited the variant from their fathers and one from the child's mother. Rare missense variants were also detected in PDZD2 (PDZ Domain Containing 2; N = 1) and SPTBN5 (Spectrin Beta, Non‐erythrocytic 5; N = 2), two genes previously suggested to be associated with SA etiology. Examination of variants with autosomal recessive and X‐linked recessive inheritance identified five and two missense variants, respectively. Compound heterozygous variants were identified in several genes. In addition, 12 de novo variants were identified, all in different genes in different children. Conclusions: To our knowledge, this is the first study reporting a possible association between ID1 and non‐syndromic SA. Although maternal pregestational diabetes has been strongly associated with SA, the missense variants in ID1 identified in two of three children were paternally inherited. These findings add to the knowledge of gene variants associated with non‐syndromic SA and provide data for future studies. [ABSTRACT FROM AUTHOR]

Published
2022
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156. Frequency, Characteristics and Complications of COVID-19 in Hospitalized Infants.

Author

Hobbs, Charlotte V., Woodworth, Kate, Young, Cameron C., Jackson, Ashley M., Newhams, Margaret M., Dapul, Heda, Maamari, Mia, Hall, Mark W., Maddux, Aline B., Singh, Aalok R., Schuster, Jennifer E., Rowan, Courtney M. r, Fitzgerald, Julie C., Irby, Katherine, Kong, Michele, Mack, Elizabeth H. MS, Staat, Mary A., Cvijanovich, Natalie Z., Bembea, Melania M., and Coates, Bria M.

Published
2022
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164. Parasitic Infection Surveillance in Mississippi Delta Children

Author

Bradbury, Richard S., primary, Arguello, Irene, additional, Lane, Meredith, additional, Cooley, Gretchen, additional, Handali, Sukwan, additional, Dimitrova, Silvia D., additional, Nascimento, Fernanda S., additional, Jameson, Sam, additional, Hellmann, Kathryn, additional, Tharp, Michelle, additional, Byers, Paul, additional, Montgomery, Susan P., additional, Haynie, Lisa, additional, Kirmse, Brian, additional, Pilotte, Nils, additional, Williams, Steven A., additional, and Hobbs, Charlotte V., additional

Published
2020
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165. Maternal Hypertension-Related Genotypes and Congenital Heart Defects

Author

Lei, Yunping, primary, Ludorf, Katherine L, additional, Yu, Xiao, additional, Benjamin, Renata H, additional, Gu, Xue, additional, Lin, Ying, additional, Finnell, Richard H, additional, Mitchell, Laura E, additional, Musfee, Fadi I, additional, Malik, Sadia, additional, Canfield, Mark A, additional, Morrison, Alanna C, additional, Hobbs, Charlotte A, additional, Van Zutphen, Alissa R, additional, Fisher, Sarah, additional, and Agopian, A J, additional

Published
2020
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166. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

Author

Feldstein, Leora R., primary, Rose, Erica B., additional, Horwitz, Steven M., additional, Collins, Jennifer P., additional, Newhams, Margaret M., additional, Son, Mary Beth F., additional, Newburger, Jane W., additional, Kleinman, Lawrence C., additional, Heidemann, Sabrina M., additional, Martin, Amarilis A., additional, Singh, Aalok R., additional, Li, Simon, additional, Tarquinio, Keiko M., additional, Jaggi, Preeti, additional, Oster, Matthew E., additional, Zackai, Sheemon P., additional, Gillen, Jennifer, additional, Ratner, Adam J., additional, Walsh, Rowan F., additional, Fitzgerald, Julie C., additional, Keenaghan, Michael A., additional, Alharash, Hussam, additional, Doymaz, Sule, additional, Clouser, Katharine N., additional, Giuliano, John S., additional, Gupta, Anjali, additional, Parker, Robert M., additional, Maddux, Aline B., additional, Havalad, Vinod, additional, Ramsingh, Stacy, additional, Bukulmez, Hulya, additional, Bradford, Tamara T., additional, Smith, Lincoln S., additional, Tenforde, Mark W., additional, Carroll, Christopher L., additional, Riggs, Becky J., additional, Gertz, Shira J., additional, Daube, Ariel, additional, Lansell, Amanda, additional, Coronado Munoz, Alvaro, additional, Hobbs, Charlotte V., additional, Marohn, Kimberly L., additional, Halasa, Natasha B., additional, Patel, Manish M., additional, and Randolph, Adrienne G., additional

Published
2020
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169. Mortality in a neonate with molybdenum cofactor deficiency illustrates the need for a comprehensive rapid precision medicine system

Author

Kingsmore, Stephen F., primary, Ramchandar, Nanda, additional, James, Kiely, additional, Niemi, Anna-Kaisa, additional, Feigenbaum, Annette, additional, Ding, Yan, additional, Benson, Wendy, additional, Hobbs, Charlotte, additional, Nahas, Shareef, additional, Chowdhury, Shimul, additional, and Dimmock, David, additional

Published
2020
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170. Surveillance for Soil Transmitted Helminths, Strongyloidiasis, Toxocariasis, Cryptosporidiosis and Other Parasitic Diseases in Mississippi

Author

Bradbury, Richard S., primary, Lane, Meredith, additional, Arguello, Irene, additional, Handali, Sukwan, additional, Cooley, Gretchen, additional, Pilotte, Nils, additional, Williams, John M., additional, Jameson, Sam, additional, Montgomery, Susan P., additional, Hellman, Kathryn, additional, Tharp, Michelle, additional, Haynie, Lisa, additional, Galloway, Regina, additional, Brackin, Bruce, additional, Kirmse, Brian M., additional, Stempak, Lisa, additional, Byers, Paul, additional, Williams, Steven, additional, Faruque, Fazlay, additional, and Hobbs, Charlotte Victoria, additional

Published
2020
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172. Maternal Vaccination and Risk of Hospitalization for Covid-19 Among Infants.

Author

Halasa, Natasha B., Olson, Samantha M., Staat, Mary A., Newhams, Margaret M., Price, Ashley M., Pannaraj, Pia S., Boom, Julie A., Sahni, Leila C., Chiotos, Kathleen, Cameron, Melissa A., Bline, Katherine E., Hobbs, Charlotte V., Maddux, Aline B., Coates, Bria M., Michelson, Kelly N., Heidemann, Sabrina M., Irby, Katherine, Nofziger, Ryan A., Mack, Elizabeth H., and Smallcomb, Laura

Published
2023
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173. Ten Facts about Toxocariasis.

Author

INAGAKI, KENGO, WILLIAMS, JOHN M., PALMER, APRIL, and HOBBS, CHARLOTTE V.

Abstract

Toxocariasis is caused by larval stages of the parasite, Toxocara spp. This parasite is a helminth that infects dogs and cats, and when it infects humans, it cannot complete its life cycle in humans. Migrating larvae of these zoonotic ascarids may be associated with significant pathology by wandering through extraintestinal viscera, causing tissue necrosis and provoking eosinophilic granulomatous inflammation. The clinical syndromes of visceral larva migrans (VLM), neural larva migrans (NLM), ocular larva migrans (OLM), or covert toxocariasis are most commonly caused by larvae of the dog ascarid Toxocara canis and, less frequently, the cat ascarid Toxocara cati. Covert toxocariasis refers to asymptomatic or paucisymptomatic infection, and this clinical entity remains a controversial condition/diagnosis due to the large number of seropositive asymptomatic patients. However, associations of positive antibody status and respiratory presentations such as asthma and wheezing, other subtle allergic presentations, epilepsy, and neurocognitive developmental delays have been reported in some studies. This review gives a brief overview for the clinician, providing a knowledge base for recognition of this disease, which is more highly prevalent in the American South, including the state of Mississippi. [ABSTRACT FROM AUTHOR]

Published
2023

182. Detecting methylation quantitative trait loci using a methylation random field method.

Author

Lyu, Chen, Huang, Manyan, Liu, Nianjun, Chen, Zhongxue, Lupo, Philip J, Tycko, Benjamin, Witte, John S, Hobbs, Charlotte A, and Li, Ming

Subjects
LOCUS (Genetics), RANDOM fields, METHYLATION, CONGENITAL heart disease, BETA distribution, GENE expression
Abstract

DNA methylation may be regulated by genetic variants within a genomic region, referred to as methylation quantitative trait loci (mQTLs). The changes of methylation levels can further lead to alterations of gene expression, and influence the risk of various complex human diseases. Detecting mQTLs may provide insights into the underlying mechanism of how genotypic variations may influence the disease risk. In this article, we propose a methylation random field (MRF) method to detect mQTLs by testing the association between the methylation level of a CpG site and a set of genetic variants within a genomic region. The proposed MRF has two major advantages over existing approaches. First, it uses a beta distribution to characterize the bimodal and interval properties of the methylation trait at a CpG site. Second, it considers multiple common and rare genetic variants within a genomic region to identify mQTLs. Through simulations, we demonstrated that the MRF had improved power over other existing methods in detecting rare variants of relatively large effect, especially when the sample size is small. We further applied our method to a study of congenital heart defects with 83 cardiac tissue samples and identified two mQTL regions, MRPS10 and PSORS1C1 , which were colocalized with expression QTL in cardiac tissue. In conclusion, the proposed MRF is a useful tool to identify novel mQTLs, especially for studies with limited sample sizes. [ABSTRACT FROM AUTHOR]

Published
2021
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183. A Description of COVID-19-Directed Therapy in Children Admitted to US Intensive Care Units 2020

Author

Schuster, Jennifer E, Halasa, Natasha B, Nakamura, Mari, Levy, Emily R, Fitzgerald, Julie C, Young, Cameron C, Newhams, Margaret M, Bourgeois, Florence, Staat, Mary A, Hobbs, Charlotte V, Dapul, Heda, Feldstein, Leora R, Jackson, Ashley M, Mack, Elizabeth H, Walker, Tracie C, Maddux, Aline B, Spinella, Philip C, Loftis, Laura L, Kong, Michele, Rowan, Courtney M, Bembea, Melania M, McLaughlin, Gwenn E, Hall, Mark W, Babbitt, Christopher J, Maamari, Mia, Zinter, Matt S, Cvijanovich, Natalie Z, Michelson, Kelly N, Gertz, Shira J, Carroll, Christopher L, Thomas, Neal J, Giuliano, John S, Singh, Aalok R, Hymes, Saul R, Schwarz, Adam J, McGuire, John K, Nofziger, Ryan A, Flori, Heidi R, Clouser, Katharine N, Wellnitz, Kari, Cullimore, Melissa L, Hume, Janet R, Patel, Manish, and Randolph, Adrienne G

Abstract

No therapies for acute coronavirus disease 2019 (COVID-19) have been tested in children to establish effectiveness. Despite this, across 48 hospitals, 235/424 children (55%) admitted to the intensive care or step-down unit with COVID-19 received directed therapies. Systemic steroids and remdesivir were most commonly administered, with use rising from March 2020 to December 2020.

Published
2022
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187. A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants.

Author

Kingsmore, Stephen F, Kingsmore, Stephen F, Cakici, Julie A, Clark, Michelle M, Gaughran, Mary, Feddock, Michele, Batalov, Sergey, Bainbridge, Matthew N, Carroll, Jeanne, Caylor, Sara A, Clarke, Christina, Ding, Yan, Ellsworth, Katarzyna, Farnaes, Lauge, Hildreth, Amber, Hobbs, Charlotte, James, Kiely, Kint, Cyrielle I, Lenberg, Jerica, Nahas, Shareef, Prince, Lance, Reyes, Iris, Salz, Lisa, Sanford, Erica, Schols, Peter, Sweeney, Nathaly, Tokita, Mari, Veeraraghavan, Narayanan, Watkins, Kelly, Wigby, Kristen, Wong, Terence, Chowdhury, Shimul, Wright, Meredith S, Dimmock, David, RCIGM Investigators, Kingsmore, Stephen F, Kingsmore, Stephen F, Cakici, Julie A, Clark, Michelle M, Gaughran, Mary, Feddock, Michele, Batalov, Sergey, Bainbridge, Matthew N, Carroll, Jeanne, Caylor, Sara A, Clarke, Christina, Ding, Yan, Ellsworth, Katarzyna, Farnaes, Lauge, Hildreth, Amber, Hobbs, Charlotte, James, Kiely, Kint, Cyrielle I, Lenberg, Jerica, Nahas, Shareef, Prince, Lance, Reyes, Iris, Salz, Lisa, Sanford, Erica, Schols, Peter, Sweeney, Nathaly, Tokita, Mari, Veeraraghavan, Narayanan, Watkins, Kelly, Wigby, Kristen, Wong, Terence, Chowdhury, Shimul, Wright, Meredith S, Dimmock, David, and RCIGM Investigators

Abstract

The second Newborn Sequencing in Genomic Medicine and Public Health study was a randomized, controlled trial of the effectiveness of rapid whole-genome or -exome sequencing (rWGS or rWES, respectively) in seriously ill infants with diseases of unknown etiology. Here we report comparisons of analytic and diagnostic performance. Of 1,248 ill inpatient infants, 578 (46%) had diseases of unknown etiology. 213 infants (37% of those eligible) were enrolled within 96 h of admission. 24 infants (11%) were very ill and received ultra-rapid whole-genome sequencing (urWGS). The remaining infants were randomized, 95 to rWES and 94 to rWGS. The analytic performance of rWGS was superior to rWES, including variants likely to affect protein function, and ClinVar pathogenic/likely pathogenic variants (p < 0.0001). The diagnostic performance of rWGS and rWES were similar (18 diagnoses in 94 infants [19%] versus 19 diagnoses in 95 infants [20%], respectively), as was time to result (median 11.0 versus 11.2 days, respectively). However, the proportion diagnosed by urWGS (11 of 24 [46%]) was higher than rWES/rWGS (p = 0.004) and time to result was less (median 4.6 days, p < 0.0001). The incremental diagnostic yield of reflexing to trio after negative proband analysis was 0.7% (1 of 147). In conclusion, rapid genomic sequencing can be performed as a first-tier diagnostic test in inpatient infants. urWGS had the shortest time to result, which was important in unstable infants, and those in whom a genetic diagnosis was likely to impact immediate management. Further comparison of urWGS and rWES is warranted because genomic technologies and knowledge of variant pathogenicity are evolving rapidly.

Published
2019

188. Exome sequencing of child–parent trios with bladder exstrophy: Findings in 26 children.

Author

Pitsava, Georgia, Feldkamp, Marcia L., Pankratz, Nathan, Lane, John, Kay, Denise M., Conway, Kristin M., Shaw, Gary M., Reefhuis, Jennita, Jenkins, Mary M., Almli, Lynn M., Olshan, Andrew F., Pangilinan, Faith, Brody, Lawrence C., Sicko, Robert J., Hobbs, Charlotte A., Bamshad, Mike, McGoldrick, Daniel, Nickerson, Deborah A., Finnell, Richard H., and Mullikin, James

Abstract

Bladder exstrophy (BE) is a rare, lower ventral midline defect with the bladder and part of the urethra exposed. The etiology of BE is unknown but thought to be influenced by genetic variation with more recent studies suggesting a role for rare variants. As such, we conducted paired‐end exome sequencing in 26 child/mother/father trios. Three children had rare (allele frequency ≤ 0.0001 in several public databases) inherited variants in TSPAN4, one with a loss‐of‐function variant and two with missense variants. Two children had loss‐of‐function variants in TUBE1. Four children had rare missense or nonsense variants (one per child) in WNT3, CRKL, MYH9, or LZTR1, genes previously associated with BE. We detected 17 de novo missense variants in 13 children and three de novo loss‐of‐function variants (AKR1C2, PRRX1, PPM1D) in three children (one per child). We also detected rare compound heterozygous loss‐of‐function variants in PLCH2 and CLEC4M and rare inherited missense or loss‐of‐function variants in additional genes applying autosomal recessive (three genes) and X‐linked recessive inheritance models (13 genes). Variants in two genes identified may implicate disruption in cell migration (TUBE1) and adhesion (TSPAN4) processes, mechanisms proposed for BE, and provide additional evidence for rare variants in the development of this defect. [ABSTRACT FROM AUTHOR]

Published
2021
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189. Parasitic Disease Surveillance, Mississippi, USA.

Author

Bradbury, Richard S., Lane, Meredith, Arguello, Irene, Handali, Sukwan, Cooley, Gretchen, Pilotte, Nils, Williams, John M., Jameson, Sam, Montgomery, Susan P., Hellmann, Kathryn, Tharp, Michelle, Haynie, Lisa, Galloway, Regina, Brackin, Bruce, Kirmse, Brian, Stempak, Lisa, Byers, Paul, Williams, Steven, Faruque, Fazlay, and Hobbs, Charlotte V.

Subjects
PARASITIC diseases, HELMINTHS, GIARDIASIS, GIARDIA lamblia, HOOKWORM disease, STRONGYLOIDIASIS, CRYPTOSPORIDIOSIS, CRYPTOSPORIDIUM
Abstract

Surveillance for soil-transmitted helminths, strongyloidiasis, cryptosporidiosis, and giardiasis was conducted in Mississippi, USA. PCR performed on 224 fecal samples for all soil-transmitted helminths and on 370 samples for only Necator americanus and Strongyloides stercoralis identified 1 S. stercoralis infection. Seroprevalences were 8.8% for Toxocara, 27.4% for Cryptosporidium, 5.7% for Giardia, and 0.2% for Strongyloides parasites. [ABSTRACT FROM AUTHOR]

Published
2021
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190. In Reply

Author

Hobbs, Charlotte A., Cleves, Mario A., and Simmons, Caroline J.

Published
2002

192. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome.

Author

LaRovere, Kerri L., Riggs, Becky J., Poussaint, Tina Y., Young, Cameron C., Newhams, Margaret M., Maamari, Mia, Walker, Tracie C., Singh, Aalok R., Dapul, Heda, Hobbs, Charlotte V., McLaughlin, Gwenn E., Son, Mary Beth F., Maddux, Aline B., Clouser, Katharine N., Rowan, Courtney M., McGuire, John K., Fitzgerald, Julie C., Gertz, Shira J., Shein, Steven L., and Munoz, Alvaro Coronado

Published
2021
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193. Cheek swabs, SNP chips, and CNVs: Assessing the quality of copy number variant calls generated with subject-collected mail-in buccal brush DNA samples on a high-density genotyping microarray

Author

Erickson Stephen W, MacLeod Stewart L, and Hobbs Charlotte A

Subjects
SNPs, Single nucleotide polymorphisms, CNVs, Copy number variants, NBDPS, National Birth Defects Prevention Study, Buccal brush, Internal medicine, RC31-1245, Genetics, QH426-470
Abstract

Abstract Background Multiple investigators have established the feasibility of using buccal brush samples to genotype single nucleotide polymorphisms (SNPs) with high-density genome-wide microarrays, but there is currently no consensus on the accuracy of copy number variants (CNVs) inferred from these data. Regardless of the source of DNA, it is more difficult to detect CNVs than to genotype SNPs using these microarrays, and it therefore remains an open question whether buccal brush samples provide enough high-quality DNA for this purpose. Methods To demonstrate the quality of CNV calls generated from DNA extracted from buccal samples, compared to calls generated from blood samples, we evaluated the concordance of calls from individuals who provided both sample types. The Illumina Human660W-Quad BeadChip was used to determine SNPs and CNVs of 39 Arkansas participants in the National Birth Defects Prevention Study (NBDPS), including 16 mother-infant dyads, who provided both whole blood and buccal brush DNA samples. Results We observed a 99.9% concordance rate of SNP calls in the 39 blood–buccal pairs. From the same dataset, we performed a similar analysis of CNVs. Each of the 78 samples was independently segmented into regions of like copy number using the Optimal Segmentation algorithm of Golden Helix SNP & Variation Suite 7. Across 640,663 loci on 22 autosomal chromosomes, segment-mean log R ratios had an average correlation of 0.899 between blood-buccal pairs of samples from the same individual, while the average correlation between all possible blood-buccal pairs of samples from unrelated individuals was 0.318. An independent analysis using the QuantiSNP algorithm produced average correlations of 0.943 between blood-buccal pairs from the same individual versus 0.332 between samples from unrelated individuals. Segment-mean log R ratios had an average correlation of 0.539 between mother-offspring dyads of buccal samples, which was not statistically significantly different than the average correlation of 0.526 between mother-offspring dyads of blood samples (p=0.302). Conclusions We observed performance from the subject-collected mail-in buccal brush samples comparable to that of blood. These results show that such DNA samples can be used for genome-wide scans of both SNPs and CNVs, and that high rates of CNV concordance were achieved whether using a change-point-based algorithm or one based on a hidden Markov model (HMM).

Published
2012
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194. Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults

Author

Healy, Sara A, primary, Murphy, Sean C, additional, Hume, Jen C C, additional, Shelton, Lisa, additional, Kuntz, Steve, additional, Van Voorhis, Wesley C, additional, Moodie, Zoe, additional, Metch, Barbara, additional, Wang, Ruobing, additional, Silver-Brace, Tiffany, additional, Fishbaugher, Matthew, additional, Kennedy, Mark, additional, Finney, Olivia C, additional, Chaturvedi, Richa, additional, Marcsisin, Sean R, additional, Hobbs, Charlotte V, additional, Warner-Lubin, Margaret, additional, Talley, Angela K, additional, Wong-Madden, Sharon, additional, Stuart, Ken, additional, Wald, Anna, additional, Kappe, Stefan H, additional, Kublin, James G, additional, and Duffy, Patrick E, additional

Published
2019
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196. A Randomized, Controlled Trial of the Analytic and Diagnostic Performance of Singleton and Trio, Rapid Genome and Exome Sequencing in Ill Infants

Author

Kingsmore, Stephen F., primary, Cakici, Julie A., additional, Clark, Michelle M., additional, Gaughran, Mary, additional, Feddock, Michele, additional, Batalov, Sergey, additional, Bainbridge, Matthew N., additional, Carroll, Jeanne, additional, Caylor, Sara A., additional, Clarke, Christina, additional, Ding, Yan, additional, Ellsworth, Katarzyna, additional, Farnaes, Lauge, additional, Hildreth, Amber, additional, Hobbs, Charlotte, additional, James, Kiely, additional, Kint, Cyrielle I., additional, Lenberg, Jerica, additional, Nahas, Shareef, additional, Prince, Lance, additional, Reyes, Iris, additional, Salz, Lisa, additional, Sanford, Erica, additional, Schols, Peter, additional, Sweeney, Nathaly, additional, Tokita, Mari, additional, Veeraraghavan, Narayanan, additional, Watkins, Kelly, additional, Wigby, Kristen, additional, Wong, Terence, additional, Chowdhury, Shimul, additional, Wright, Meredith S., additional, Dimmock, David, additional, Bezares, Zaira, additional, Bloss, Cinnamon, additional, Braun, Joshua J.A., additional, Diaz, Carlos, additional, Mashburn, Dana, additional, Tamang, Dorjee, additional, Orendain, Daniken, additional, Friedman, Jenni, additional, Gleeson, Joe, additional, Barea, Jaime, additional, Chiang, George, additional, Cohenmeyer, Casey, additional, Coufal, Nicole G., additional, Evans, Marva, additional, Honold, Jose, additional, Hovey, Raymond L., additional, Kimball, Amy, additional, Lane, Brian, additional, Le, Crystal, additional, Le, Jennie, additional, Leibel, Sandra, additional, Moyer, Laurel, additional, Mulrooney, Patrick, additional, Oh, Daeheon, additional, Ordonez, Paulina, additional, Oriol, Albert, additional, Ortiz-Arechiga, Maria, additional, Puckett, Laura, additional, Speziale, Mark, additional, Suttner, Denise, additional, Van Der Kraan, Lucitia, additional, Knight, Gail, additional, Sauer, Charles, additional, Song, Richard, additional, White, Sarah, additional, Wise, Audra, additional, and Yamada, Catherine, additional

Published
2019
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197. Hypospadias Prevalence and Trends in International Birth Defect Surveillance Systems, 1980–2010

Author

Yu, Xiao, primary, Nassar, Natasha, additional, Mastroiacovo, Pierpaolo, additional, Canfield, Mark, additional, Groisman, Boris, additional, Bermejo-Sánchez, Eva, additional, Ritvanen, Annukka, additional, Kiuru-Kuhlefelt, Sonja, additional, Benavides, Adriana, additional, Sipek, Antonin, additional, Pierini, Anna, additional, Bianchi, Fabrizio, additional, Källén, Karin, additional, Gatt, Miriam, additional, Morgan, Margery, additional, Tucker, David, additional, Canessa, M. Aaurora, additional, Gajardo, Rosa, additional, Mutchinick, Osvaldo M., additional, Szabova, Elena, additional, Csáky-Szunyogh, Melinda, additional, Tagliabue, Giovanna, additional, Cragan, Janet D., additional, Nembhard, Wendy N., additional, Rissmann, Anke, additional, Goetz, Dorit, additional, Bower, Carol, additional, Baynam, Gareth, additional, Lowry, R. Brian, additional, Leon, Juan A., additional, Luo, Wei, additional, Rouleau, Jocelyn, additional, Zarante, Ignacio, additional, Fernandez, Nicolas, additional, Amar, Emmanuelle, additional, Dastgiri, Saeed, additional, Contiero, Paolo, additional, Martínez-de-Villarreal, Laura E., additional, Borman, Barry, additional, Bergman, J.E.H., additional, de Walle, Hermien E.K., additional, Hobbs, Charlotte A., additional, Nance, Amy E., additional, and Agopian, A.J., additional

Published
2019
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198. The role of genetic variation in DGKK on moderate and severe hypospadias

Author

Richard, Melissa A., primary, Sok, Pagna, additional, Canon, Stephen, additional, Brown, Austin L., additional, Peckham‐Gregory, Erin C., additional, Nembhard, Wendy N., additional, Carmichael, Suzan L., additional, Ehli, Erik A., additional, Kallsen, Noah A., additional, Peyton, Shanna A., additional, Davies, Gareth E., additional, Patel, Ashay, additional, Zamilpa, Ismael, additional, Wyatt, Richard A., additional, Hobbs, Charlotte A., additional, Scheurer, Michael E., additional, and Lupo, Philip J., additional

Published
2019
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