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This paper introduces a new approach for solving fractional differential algebraic equations (FDAEs) by using the operational matrix of Riem-man Liouville (RL) fractional integral of the shifted Gegenbauer polynomials. By using the new shifted Gegenbauer operational matrix (SGOM) of RL fractional integral, the FDAEs are transformed into a system of algebraic equations which are easily to solve. Numerical examples associated by numerical comparisons with other methods in the literature are introduced to illustrate the efficiency and accuracy of the proposed approach. [ABSTRACT FROM AUTHOR]

Through this article, a numerical scheme based upon the modified fractional Euler method (MFEM) is introduced to find the numerical solutions of linear and nonlinear systems of fractional differential equations (SFDEs) as well as nonlinear multi-order fractional differential equations (MOFDEs). The fractional derivatives are defined by Caputo. The proposed algorithm is very simple and provides the solutions directly without linearization, perturbations or any other assumptions. Illustrating examples with numerical comparisons between the proposed algorithm and the exact and/or fourth order Runge Kutta method (RK4) are given to reveal the efficiency and the accuracy of our algorithm. [ABSTRACT FROM AUTHOR]

Background: Crohn’s Disease (CD) is a type of inflammatory bowel disease that, despite its unknown etiology, is generally associated with genetics, immune system, and environmental factors. In this study, we uncover transcriptional signatures in patients with CD and subsequently explain the putative molecular pathways in the inflamed and non-inflamed intestinal mucosa. Materials and Methods: We obtain GSE83448 gene expression profiles from the Omnibus gene expression database. Also, for the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of Differentially Expressed Gene (DEG) pathways, we used DAVID software. DEGs were detected in the inflamed and non-inflamed intestinal mucosa of CD patients compared to the control group using the GEO2R instrument. Significant modules and hub genes were identified after producing protein-protein interaction (PPIs) networks of DEGs using Cytoscape software. Results: The 10 specific hub genes of CD, including Matrix Metallopeptidase 2 (MMP2), Cadherin 1 (CDH1), Periostin (POSTN), Collagen type I alpha 2 chain (COL1A2), C-X-C motif chemokine ligand 8 (CXCL8), Collagen type III alpha 1 chain (COL3A1), JUN, Serine Protease Inhibitor clade E member 1 (SERPINE1), Integrin alpha M (ITGAM), and Connective Tissue Growth Factor (CTGF), were used as biomarkers to discriminate between inflamed and non-inflamed intestinal mucosa groups in patients. Conclusion: These findings could lead to new molecular targets and diagnostic biomarkers for both inflamed and non-inflamed intestinal mucosa in CD patients.

Abstract Background Plant-associated microbes (endophytes) have a significant relationship to enhance plant growth and crop productivity by producing proficient bioactive metabolites. Since endophytes promoted plant growth either directly by releasing active metabolites such as phytohormones or indirectly by suppressing the growth of phytopathogens, so, in this work, biomass yield of local endophytic Trichoderma harzianum was maximized at shake-flask scale and scaled up via 7-L Bioflo310 fermenter using continuous exponential fed-batch fermentation mode. Subsequently, the effect of these cells as bio-fertilizer was assessed using two-barley grain genotypes (Russian and Egyptian seeds) via an intelligent hydroponic system based on Internet of Things (IoT). Results To reduce the cost of a biomass production line, agro-waste media containing potato, onion, garlic, pea, and cabbage peels were chosen as the culturing medium. The pea peel medium was found to be the best producer of biomass (2.2 g/L). The cultivation factors were evaluated to improve this biomass yield. The results showed that the maximum biomass production (4.9 g/L) was reported by adjusting the medium pH at 5.0 that inoculated with 10% of spore suspension, then incubated at 30°C, and 200 rpm. Then, this biomass yield was scaled up kinetically (505.4 g/L) by using exponential fed-batch fermentation mode via a 7-L bioreactor. The stimulation impacts of this endophytic T. harzianum on the growth of different barley genotypes (Russian and Egyptian seeds) were determined using a controlled hydroponic chamber. The total chlorophyll, carotenoid, and carbohydrate amounts in treated Russian showed the proficient stimulation percentage (81.05, 80, 40.8%) compared to the Egyptian barley groups (76.39, 73.5, 25.9%) respectively. Also, the maximum carbohydrate content (83.95 ± 1.7%) was recorded in the case of Russian barley. Conclusion Via this work, the optimal combination conditions for the cost-effective biomass production of endophytic T. harzianum were designed industrially via a fed-batch fermentation system using the cheapest culturing medium. Furthermore, by applying this promising bio-fertilizer, the total cost of barley production via an IoT hydroponic growing system was reduced. Besides, these animal diets (sprouted barley) could be produced in 3 cycles per month.

The negative effects of climate change have burdened humanity with the necessity of decarbonization by moving to clean and renewable sources of energy generation. While energy demand varies across the sectors, fisheries, including fishing and aquaculture, are among the most energy intensive processes in the food production industry. The synergistic opportunities for co-located aquaculture and renewable energy can thus provide a multifunctional use of space and resources, creating opportunities to meet the identified energy demands of a variety of aquaculture operations. This study has investigated a sustainable energy model for a small-scale shrimp farm in western Taiwan with synergies for the dual use of the water area for solar photovoltaic electricity generation and aquaculture. Based on the simulation results and SWOT analysis, recommendations have been made for the design and operation of a solar-powered aeration system for shrimp farms. The average monthly energy production of 32 MWh is attainable at the estimated canopy space on a carport by installing 896 solar modules on the proposed site, fully covering the power demand of the shrimp farm. These findings have significance for encouraging effective practices in deploying solar techniques in aquaculture and making them replicable in global settings.

Background and Aim: The World Health Organization and the Food and Agriculture Organization list Taenia saginata, a foodborne cestode, as the most widely distributed human tapeworm worldwide. The larval stage of T. saginata, Cysticercus bovis, causes cysticercosis in bovines and infects humans who eat raw or undercooked beef. The existing detection methods of C. bovis in cattle depend on the visual inspection of meat. This study aimed to confirm the identification of C. bovis through visual inspection at the slaughterhouses in North Egypt with a molecular diagnosis. Materials and Methods: A total of 687 locally bred cattle (Baladi), including 428 cows and 259 buffaloes, slaughtered in four slaughterhouses in North Egypt from April 2018 to February 2019 were inspected for C. bovis using the traditional meat inspection method. Positive samples were verified through polymerase chain reaction (PCR) amplification and HDP2 gene sequencing. Results: Through visual inspection, C. bovis was detected in 4.2% and 12.4% of the slaughtered cows and buffaloes, respectively. Molecular analysis confirmed that 1.9% of the animals, all of which were cows, had C. bovis infection. DNA sequencing verified the identity of the PCR-amplified product. Conclusion: The rate of C. bovis infection in slaughterhouses detected through meat inspection is overestimated compared with that through PCR. Although meat inspection can be used as a primary screening tool for C. bovis, a more specific molecular method is required to achieve an accurate diagnosis.

The effect of using soy milk and ABT culture on various Labneh properties was investigated. Six treatments of Labneh were made from soy and buffalo milk and from their mixtures using classic and ABT-5 starters. Labneh made from soy milk had the lowest yield, acidity, redox potential (Eh), total solids (TS), fat, ash, TN, TVFA, saturated fatty acids (SFA), monounsaturated fatty acids (MUSFA), and total amino acids contents while buffalo's milk Labneh had the highest. Soy milk Labneh had the highest level of unsaturated fatty acids (USFA), polyunsaturated fatty acids (PUSFA) and linoleic acid and α-linolenic acid. Also, soy milk Labneh had the greatest count of Str. thermophillus, L. acidophilus and bifidobacteria. Utilization of soy milk only or mixed with buffalo milk in Labneh manufacture decreased the count of L. bulgaricus. Mixing of buffalo milk with soy milk increased the sensory evaluation scores of Labneh. Classic starter Labneh had higher values of yield, acidity, WSN, TVFA, SFA and lower values of pH than those of ABT Labneh. Using of ABT culture in Labneh manufacturing increased USFA and total free amino acids contents. ABT Labneh had higher numbers of Str. thermophillus than those of classic starter. [ABSTRACT FROM AUTHOR]

Introduction: Non-surgical endodontic retreatment is highly dependent on the removal of previous root filling material, bacteria and necrotic tissue. Various techniques and instruments have been used for endodontic retreatment. Recently, the XP-endo Finisher has been introduced in endodontic treatment to clean highly complex morphologies and difficult to reach areas. Aims: a) To compare the effectiveness of XP-endo Finisher and ProTaper universal retreatment system with or without organic solvent in removing gutta-percha. b) To compare the amount of apically extruded debris between the groups. Methods: 24-human- extracted, single-rooted teeth were divided into three groups of 8. The groups were classified as follows: Group I: using a ProTaper universal retreatment system with chloroform. Group II: using a ProTaper universal retreatment system without chloroform. Group III: using a ProTaper universal retreatment system followed by XP-endo Finisher without chloroform. The apically extruded debris was collected during the retreatment and weighted. The roots were split longitudinally. The degree of dentinal tubules patency was evaluated by scanning electron microscopy. Results: The most intensely clear dentinal tubules were observed in group III, followed by group II and group I, respectively. Group I resulted in a debris extrusion, significantly less, as compared with the other groups (P < 0.05). While there was no notable difference between group II and group III (P > 0.05). Conclusion: Under the conditions of the present study, out of all the retreatment techniques that were used, the XPendo Finisher was the most effective in the removal of the gutta-percha in cervical, middle and apical thirds. The use of solvent during retreatment can decrease the amount of the apically extruded debris.

In the current study, the nanofiber gel of tomato pomace was prepared using a super disk grinder device available at Nano Novin Polymer Co., Iran. Three different concentrations (2, 4 and 6%) of the gel prepared and rheological tests including amplitude sweep, frequency sweep, temperature sweep, and flow behavior were done. DLS results showed that the average diameter of tomato nano-gel was around 38 nm. The power law model was chosen as the best model for describing flow behavior data. All samples showed a shear-thinning behavior that viscosity decreased with increasing shear rate. A hysteresis loop was observed in all samples which confirmed the thixotropic characteristic of gels. Based on amplitude sweep data, elastic modulus (G') was higher than viscous modulus (G"), in addition, crossover points of all gels showed that the flowability decreased with increasing concentrations. Based on frequency data, G' in all concentrations was higher than G" and both parameters increased with increasing concentration from 2 to 6%. In lower frequencies, all gels showed solid-like behavior while G' and G" increased with increasing frequency indicating the weakening of the gel network. G' and G" gradually decreased with increasing temperature from 5 to 50 ºC which confirmed that all gels were weakened at high temperatures, but in the cooling cycle, all gels recovered their structures and no remarkable hysteresis was observed.

Introduction: The primary concern with the current system of ordering laboratory tests is that many tests are obtained that do not contribute beneficially to patient care. Unnecessary tests create additional risks, inefficient operating room programs, and unnecessary costs for the patient.UnnecThe aim of this study was to determine the frequency distribution of results of endocrine ordered lab tests among the patients of Oral Medicine Department Of Yazd Dental School in the years 2015-2016. Methods: This cross-sectional descriptive study was performed on 273 patients referred to the Department of Oral and Maxillofacial Diseases from October 2015 to September 2016. Demographic data, systemic disease and their types, medical history, clinical examinations, the type of requested tests and their reasons were analyzed using SPSS V.22 software and Chi-square analysis. Results: Based on the results of this study, the mean age of the patients studied was 40 years, and the standard deviation of the age of the individuals was 14.3 (40± 14.3) with the age range of 6-83 years. Chi-square analysis showed a significant correlation between test results of FBS, HbA1c, T3, TSH, with the age of the patients (P

Purpose: Osteoarthritis is a progressive disease and the most common form of joint inflammation. Moreover, it is the most common cause of functional disability in the elderly. Among the multiple and predisposing factors influencing the disease are demographic indicators and occupational factors. The present study aimed to investigate the relationship between age, pain severity, Body Mass Index (BMI), occupation, and educational level, and the severity of functional disability in patients with Knee Osteoarthritis (KO). Methods: This descriptive study was performed on 97 KO patients referring to the Novin private physiotherapy clinic of Semnan University of Medical Sciences from April to March 2017. The study participants were selected through a simple nonprobability sampling technique. Literate individuals with the educational level of guidance school and above and diagnosed with KO were included in the study. Individuals with a history of inflammatory arthritis diseases, such as rheumatoid arthritis, soft tissue rheumatoid arthritis, fibromyalgia syndrome, bursitis, tendonitis, the neurological and vascular conditions of the lower extremity, mental problems, and malignancy were excluded from this research. The data related to the variables such as age, gender, occupation, history of osteoarthritis, pain intensity, involved side, educational level, and the Knee Injury and Osteoarthritis Outcome Score (KOOS) for knee disability were collected by a self-report questionnaire. This study was approved by the Research Ethics Committee of the University of Social Welfare and Rehabilitation Sciences. Using SPSS, Spearman’s correlation coefficients were calculated to examine the relationship between the study variables. Results: Spearman’s correlation coefficients revealed no significant correlation between the KOOS scores and age, occupation, and educational level. The obtained results suggested a poor significant association between KOOS and BMI; however, there was a strong significant correlation between KOOS and pain intensity Visual Analogue Scale (VAS) (P

Background and Objective: One of the health indices in human is normality of the number and size of blood cells. The purpose of this study was to screen for bleeding and coagulation disorders among the patients in oral medicine department of Yazd dental school. Methods: This descriptive - analytic study was performed on 273 patients referred to the oral medicine department of dental school in Yazd, Iran during 2015-16. Data of age, sex, systemic diseases and their type, medical history, patient’s clinical examinations and also the cause and type of requested laboratory tests were recorded for each sujects. Results: Bleeding and coagulation lab tests were ordered for 63 persons (23.4%) and complete blood count (CBC) for 210 persons (76.9%). The CBC of most patients with systemic diseases (53 cases, 25.2%) was normal. The most frequent systemic disorders were cardiovascular diseases (56%) and followed by bleeding disorders (19%). The most frequent abnormality of CBC components was seen in the distribution of neutrophils (84.9%). There was no significant correlation between CBC results and its components and also PT, BT and PTT with the age of the patients. Platelet counts, Hb and INR results showed a significant correlation with the age of the patients (in age range of 6-83 years) (P

The aim of this study was to determine the effectiveness of play therapy based on cognitive-behavioral therapy on challenging behaviors of high-functioning autistic children. The research method was semi-experimental with pre-test and post-test design with control group. The statistical population of this study was all children aged 8 to 12 years old with autism spectrum disorder in health care centers of Arak in 2018. In this study, 16 high-functioning autistic children were selected by available sampling method using a questionnaire for measuring the range of autism spectrum disorder. They were randomly assigned to two groups of experimental (8 subjects) and control (8 subjects) groups. The Revised Scale of Challenging Behaviours of Bodfish, Symons, Parker & Lewis (2000), was used to assess challenging behaviors. The experimental group received 10 cognitive-behavioral treatments in a 10-minute session during a one-month period, while the control group did not receive such an intervention. At the end, the two groups were evaluated again. Data were analyzed using covariance analysis. The findings of this study showed that play therapy based on cognitive-behavioral therapy has a significant role in reducing the challenging behaviors of high-functioning autistic children.

Since up to 60 percent of health care expenditures in developing countries are allocated to pharmaceutical products, utilizing this budget in order to supply pharmaceutical products is important. Good Procurement Practice (GPP) with the assistance of various ways of tendering is one of the most cost-effective methods in this matter. Studies showed that adding one extra supplier to tendering will cause 10 percent price reduction on average which is considered the most important outcome of tendering. In cases where there are many suppliers, tendering is recommended as a strong method in pricing and reimbursement. It seemed that GPP in reimbursement companies is not sufficient in Iran. Although bidding in countries that have developed in the generic markets is more common than those that are reaching this goal, it is recommended that reimbursement companies use bidding for inpatients, outpatients, specific patients and product groups, vaccines, and bulk products in cumulative and regional and national level. These would result in optimum use of the public budget.

Up to 40% of the global and 7.4-41.3% of the Middle East population are affected by Allergic Rhinitis (AR). Patients with AR versus control group experience approximately twofold pharmaceutical expenditures and 1.8-fold number of visits. Since drug utilization can show various times of developing a disease in a country, it is used as an alternative for prevalence. In this study, we try to examine and explain the consumption of anti-allergic medicines during the past 11 years to have a perspective view of these kinds of medicines. In this descriptive and cross-sectional study that investigates anti-allergic medicines over a 11-year period (2006-2017), we used the Iranian pharmaceutical statistical datasheet published by the Iranian Ministry of Health. According to treatment guidelines of AR and WHO ATC code, we categorized anti-allergic medicines into five groups (antihistamines, Beta 2 agonists, Corticosteroids, Fixed-dose, and others), Then DIDs for these groups were calculated and analyzed. Based on our findings in this study, cetirizine, Loratadine, and Inhaled Salbutamol got the highest DID among all five groups, with 99.2, 65.4, and 57.6 retrospectively. Generally based on the third level of ATC code (second-generation anti-histamines, respiratory system drugs for obstructive airway disease, respiratory system nasal preparation, and corticosteroid for systemic use) are faced with ascending market sales. Generally, with the upward trend of anti-allergic medicines, we can conclude that the incidence of AR in Iran during the past 11 years has increased, and policymakers should follow this trend concerning a better supply chain.