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PURPOSE OF REVIEW: Numerous surgical techniques are available to treat osteochondral defects of the knee. The aim of this review is to analyse these procedures, including their methodology, outcomes and limitations, to create a treatment algorithm for optimal management. RECENT FINDINGS: Osteochondral defects of the knee significantly alter the biomechanics of the joint. This can cause symptomatic and functional impairment as well as considerable risk of progressive joint degeneration. Surgical interventions aim to restore a congruent, durable joint surface providing symptomatic relief and reducing the risk of early arthritic changes. These methods include fixation, chondroplasty, microfracture, autologous matrix-induced chondrogenesis, autograft transplants, allograft transplants and autologous chondrocyte implantation. There is currently much debate as to which of these methods provides optimal treatment of osteochondral defects. SUMMARY: The overall evidence supports the use of each technique depending on the individual characteristics of the lesion. New technologies provide exciting prospects; however, long-term outcomes for these are not yet available.

In recent years, metabolic engineering has made great progress in both academic research and industrial applications. However, we have not found any articles that specifically analyze the current state of metabolic engineering in China in comparison with other countries. Here, we review the current development and future trends of global metabolic engineering, conduct an in-depth benchmarking analysis of the development situation of China's metabolic engineering, and identify current problems as well as future trends. We searched publications in the Scopus database from 2015 to September 2020 in the field of metabolic engineering, and analyzed the output in general, including publication trends, research distribution, popular journals, hot topics and vital institutions, but also analyzed the share of citations, field-weighted citation impact, and production in collaboration with strategic countries in science and technology. This study aims to serve as a reference for later studies, offering a comprehensive view of China’s contribution to metabolic engineering, and as a tool for the elaboration of national public policy in science and technology.

Purpose of Review Assessment of the musculoskeletal system requires consideration of its integrated function with the nervous system. This may be assisted by using valid and reliable methods that simulate real-life situations. Interactive virtual reality (VR) technology may introduce various auditory and visual inputs that mimic real-life scenarios. However, evidence supporting the quality and strength of evidence regarding the adequacy of its psychometric properties in assessing the musculoskeletal function has not been evaluated yet. Therefore, this study reviewed the validity and reliability of VR games and real-time feedback in assessing the musculoskeletal system. Recent Findings Nine studies were included in quality assessment. Based on outcome measures, studies were categorized into range of motion (ROM), balance, reaction time, and cervical motion velocity and accuracy. The majority of the studies were of moderate quality and provided evidence of VR adequate concurrent and, in some cases, known-groups validity. Also, VR showed high intra-rater reliability for most of the measured outcomes. Summary Based on the included studies, there is a limited promising evidence that interactive VR using games or real-time feedback is highly valid and reliable in assessing ROM in asymptomatic participants and patients with chronic neck pain and radial fracture. For the remaining outcomes, evidence is limited to draw a robust conclusion. Future studies are recommended to test VR psychometric properties in different patients’ population using a rigor research methodology.

PURPOSE OF REVIEW: A wide array of nonoperative modalities to treat hip pain are aimed at restoring and maintaining the structural and physiologic characteristics of the joint. The purpose of this review is to describe the current understanding of biologics in hip pathology by providing an evidence-based overview of treatment modalities available for orthopedic surgeons. RECENT FINDINGS: The use of biologics as a primary treatment or adjunct to traditional management has shown encouraging results for the treatment of hip pain. Studies have demonstrated safety with minimal complications when using platelet rich plasma, hyaluronic acid, or stem cells to treat hip pain caused by osteoarthritis, femoroacetabular impingement syndrome, tendinopathy, or osteonecrosis of the femoral head. Several studies have been able to demonstrate meaningful clinical results that can improve treatment standards for hip pain; however, more work must be performed to better delineate the appropriate protocols, indications, and limitations of each modality. SUMMARY: Recent advances have inspired renewed interest in biologics for patients with hip pain. We present a concise review of platelet rich plasma, hyaluronic acid, stem cells, and matrix metalloprotease inhibitors and their applicability to hip preservation surgery.

PURPOSE OF REVIEW: The triquetrum is the second most commonly fractured carpal bone, comprising 15–18% of all carpal bone fractures. This review summarizes the current knowledge of triquetral fractures, including the anatomy and pathophysiology, evaluation and diagnosis, treatment and management, post-treatment outcomes, and complications. RECENT FINDINGS: Triquetral fractures are frequently caused by impaction of the ulnar wrist after a fall on an outstretched hand or by avulsion of attached ligaments. There are three main types of triquetral fractures: dorsal cortical fractures, triquetral body fractures, and volar cortical fractures. Dorsal cortical fractures are the most common and are usually benign, while volar cortical fractures are the least common and can be problematic. Nonsurgical management is indicated for most triquetral fractures, which usually results in good outcomes. Surgical treatment is indicated for fractures with significant displacement or evidence of instability. Complications of triquetral fractures include non-union, triangular fibrocartilage complex injury, and pisotriquetral arthritis. SUMMARY: While less common than scaphoid fractures, triquetral fractures should remain in the differential diagnosis for patients with ulnar-sided wrist pain after falling on an outstretched hand. Most triquetral fractures can be treated with immobilization, though they should be thoroughly evaluated due to their potential to result in instability, loss of motion, and arthrosis. Further research is needed to determine the best method of surgical treatment.

PURPOSE OF REVIEW: To describe the (1) indications, (2) preoperative precautions, and (3) stepwise technical details of modern femoral stem cemented fixation. RECENT FINDINGS: Femoral stem cementation provides excellent implant longevity with a low periprosthetic fracture rate among patients with compromised bone quality or aberrant anatomy. Unfamiliarity with the details of modern cementation techniques among trainees who may lack frequent exposure to cementing femoral stems may preclude them from offering this viable option to suitable patients in later stages of their careers. As such, maximizing benefit from cemented femoral stem fixation among suitable candidates is contingent upon the meticulous use of modern cementation techniques. SUMMARY: In addition to proper patient selection, modern cementation techniques emphasize the use of (1) pulsatile lavage of the femoral canal, (2) utilization of epinephrine-soaked swabs, (3) vacuum cement mixing, (4) retrograde cement introduction, (5) cement pressurization, and (6) the use of stem centralizers. Furthermore, identifying and optimizing the preoperative status of at-risk patients with pre-existing cardiopulmonary compromise, in addition to intraoperative vigilance, are essential for mitigating the risk of developing bone cement implantation syndrome. Further research is required to assess the utility of cemented femoral stem fixation among younger patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12178-020-09681-5.

Objective. The publications of application and development of shock wave therapy showed consistent growth. The aim of this study was to investigate the global status and trends in the shock wave therapy field. Methods. Publications about shock wave therapy from 1990 to 2019 were collected from the Web of Science database. The data were studied and indexed by using bibliometric methodology. For a visualized study, VOSviewer software was used to conduct bibliographic coupling analysis, coauthorship analysis, cocitation analysis, and co-occurrence analysis and to analyze the publication trends in shock wave therapy. Results. A total of 3,274 articles were included. The number of publications was increasing per year globally. The USA made the largest contributions to the global research with the most citations (the highest h -index). The Journal of Urology had the highest publication number. The University of California System was the most contributive institution. Studies could be divided into seven clusters: urology, hepatology, cardiology, orthopedics, mechanism research of shock wave therapy, andrology, and principle of shock wave therapy. Orthopedics, andrology, and mechanism research of shock wave therapy could be the next hot topics in this field. Conclusions. Base on the trends, shock wave therapy is the theme of a globally active research field which keeps developing and extends from bench to bedside.

Social media platforms are certainly at the centre of some contentious topics at the moment. At the top of the ‘hot topics’ list, when this issue of Communication Research and Practice went to prin...

On the basis of identifying the interdisciplinary research topics in the field of Library and Information Science, this paper constructed Altmetrics indicator systems and makes SOFM neural network clustering analysis on the comprehensive influence of the research topics, in order to provide reference for the interdisciplinary crossover and integration of Library and Information discipline in China under the background of “New Liberal Arts”. The study found that the 20 interdisciplinary research topics could be divided into four types according to their influence composition characteristics: comprehensive hotspots, online social hotspots, academic hotspots, potential hotspots. Interdisciplinary hot topics were important for the intersection and integration of library and information field and other disciplines, and high impact research topics deserved close attention from Chinese scholars.

In recent years, additive manufacturing, or in other words three-dimensional (3D) printing technology, has rapidly become one of the hot topics in the world. Among the vast majority of materials, chitosan and its hybrids with various wonderful features have played a noteworthy role in this science. There are lots of studies on the applications of chitosan and its derivatives in the biomedical field, but it is worth mentioning that one of the main differences of the present work with others is the consideration of the latest research on 3D bioprinted chitosan constructs, especially for biomedical applications. For this aim, this mini review starts with a definition and a brief history of 3D printing technology and the position and role of chitosan and its hybrids in this area. Subsequently, a critical discussion on current developments of chitosan for diverse applications especially for tissue engineering is provided.

The work of the representatives of the Nakhchivan literary environment at the end of the XIX century and at the beginning of the XX century in the field of publicism has been investigated in this article. The activity of the writers who had an exceptional role in the development of the literary language in the press was recorded systematically and at the same time, the linguistic features of the publicistic style of the Azerbaijani literary language have been researched. In the article not only the publicistic heritage of the representatives of Nakhchivan literary environment at the end of the XIX century and at the beginning of the XX century was investigated but also the language-style features of the articles of the literary environment representatives who worked in this field have been analyzed. In the publicism of the writers from Nakhchivan, the writing professionalism displayed it distinctly and they benefited from its strong description means. Different from fiction, publicism reaches the readers quickly through the pages of the newspapers and discusses the hot topics of daily life. In this meaning, the publicistic articles of the representatives of the literary environment not only create the social-political scene of the time they lived but also with the artistic language qualities describe that time in detail.

This research uses BICOMB, UCINET and other bibliometric analysis software to extract keywords, statistically and visually analyze the 1463 articles of The Physics Teacher in the past five years, and obtains its research hotspots and directions in the past five years and obtains some enlightenment from it. Among them, the main research hotspots of physics teaching are teaching, physics teaching aids, educational evaluation, Newtonian mechanics, physics experiment, education policy and management, learning mode, electromagnetics, student development, physics history, kinematics, geometric optics, etc.

Human health is facing a severe threat from pathogenic infections, particularly the emergence of antibiotic-resistant microorganisms has deepened the public's fear. The series of clinical diseases caused by microbial infections is constantly increasing. Therefore, they have become one of the hot topics of public health. Polymer materials display unprecedented advantages as effective antimicrobial materials due to their good biocompatibility, easy structure modification, and little proneness to developing drug resistance of pathogens. Herein, we put forward a summarization of research focused on conjugated and non-conjugated polymer materials in the field of killing pathogens in recent years with various therapeutic modes including non-photo inductive therapy, photothermal therapy (PTT) and photodynamic therapy (PDT). The current status, challenges, and future prospects of antimicrobial nanostructured materials (aNSMs) are addressed at the same time, devoted to the design and synthesis of aNSMs for ever-increasing demand of killing pathogens.

Abstract. For identifying psychological hotspot topics, a mere focus on bibliometric data suffers from a publication delay. To overcome this issue, we introduce Twitter mining of ongoing online communication among scientists for the detection of psychological research topics. Specifically, we collected the entire 69,963 tweets posted between August 2007 and July 2020 from 139 accounts of psychology professors, departments, and research institutes from the German-speaking countries, as well as sections of the German Psychological Society (DGPs). To examine whether Twitter topics are hotspots in terms of indicating future publication trends, 346,361 references in the PSYNDEX database were extracted. For determining the additional value of our approach in contrast to traditional conference analysis, we gathered all available conference programs of the DGPs and its sections since 2010 and compared dates of topic emergence. Results revealed 21 topics addressing societal issues (e.g., COVID-19), methodology (e.g., machine learning), scientific research (e.g., replication crisis), and different areas of psychological research. Ten topics indicated an increasing publication trend, particularly topics related to methodology or scientific transparency. Seven Twitter topics emerged earlier on Twitter than at conferences. A total of four topics could be expected neither by bibliometric forecasting nor conference contents: “methodological issues in meta-analyses”, “playfulness”, “preregistration”, and “mobile brain/body imaging”. Taken together, Twitter mining is a worthwhile endeavor for identifying psychological hotspot topics, especially regarding societal issues, novel research methods, and research transparency in psychology. In order to get the most comprehensive picture of research hotspots, Twitter mining is recommended in addition to bibliometric analyses of publication trends and monitoring of conference topics.

Since the first implant-based breast surgeries were performed nearly 70 years ago, breast augmentation it has changed drastically. As understanding of breast augmentation has advanced, so too have the technologies and techniques used to improve results and minimize the risk of complications in breast implant surgery. This article reviews some of the novel techniques and technologies used today in breast augmentation surgery. How these tools and techniques will withstand the test of time remains to be seen, but they no doubt will add to the fascinating and ever-evolving history of breast augmentation.

Biofuels and bio-based chemicals are getting more and more attention because of their sustainable and renewable properties and wide industrial applications. However, the low concentrations of the targeted products in their fermentation broths, the complicated components of the broths and the high energy-intensive separation and purification process hinder the competitiveness of biofuels and biochemicals with the petro-based ones. Hence, the production and the separation of biofuels and bio-based chemicals in energy-saving, low-cost and greenness ways become hot topics nowadays. This review introduces the separation technologies (salting-out extraction, salting-out, sugaring-out extraction, and sugaring-out) that extract biobutanol, 1,3-propanediol, 2,3-butanediol, acetoin, organic acids and other bio-based chemicals from fermentation broths/aqueous solutions. Salting-out/sugaring-out extraction and salting-out/sugaring-out technologies display the high separating efficiency and the high targeted product yields. In addition, they are easy to operate and require low cost for separating products. Hence, they are the effective and potential technologies for separating targeted products in the wide industrial applications. The successful research into the salting-out/ sugaring-out and salting-out/sugaring-out extraction not only affords biofuels and biochemical but also opens a door for the development of novel separation methods.

Decreased ovarian reserve is one of the hot topics in current research. This article discusses the mechanism of acupuncture treatment of decreased ovarian reserve through the current acupuncture and moxibustion experimental research on the endocrine system and immune system.

This paper quantifies output from 11 annual conferences held by the European Federation of Food Science and Technology (EFFoST) in the period 2010–2020 on a range of themes in food science/technology, innovation, sustainability, valorisation, food safety, food and health, food properties, consumer aspects and related areas. Summaries of the 11 conferences have been published in a series of 11 reports published in Trends in Food Science and Technology. Collated outputs from the 11 conferences were 283 plenary/keynote lectures, 982 theme lectures, 3196 posters and 4710 attendees. This represents a very large dissemination effort by any standard and augers well for the status of food science and technology in Europe and also more globally. Special sessions are a feature of recent EFFoST conferences, consisting of discussion platforms/forums with chairpersons and ‘hot topics’ for debate. Two examples are (i) the OLEUM project which aims to better guarantee olive oil quality and authenticity, and (ii) the valorisation of side streams. Foremost among special sessions are those for young scientists. The Young EFFoST Day provides opportunity for young food professionals to expand their competencies and networking in food science. It is a day for young scientists managed by young scientists. Networking between conference attendees at posters sessions, coffee and lunch breaks is a key part of each conference, which facilitates information exchange and the framing of new collaborative projects.

Die Frage, ob eine laufende MTX(Methotrexat)-Therapie tatsächlich die protektive Immunantwort nach SARS-CoV-2-Impfung in relevanter Form abschwächt, lässt sich anhand der vorliegenden Daten definitiv nicht beantworten. In Kenntnis der Tatsache, dass ein kurzes z. B. 1‑ oder 2‑maliges Pausieren der wöchentlichen MTX-Gabe bei Patienten in stabiler Krankheitssituation mit einem vergleichsweise geringen Risiko der Auslösung eines Schubes der Grundkrankheit verbunden ist, kann eine solche kurze Unterbrechung der Therapie nach individueller Entscheidung zwischen Patient*in und behandelnder/m Rheumatolog*in durchaus erwogen werden. Zwingend notwendig erscheint sie aber nicht – zumal diese Pause bei den meisten Impfstoffen 2‑mal innerhalb relativ kurzer Zeit erfolgen müsste. Keinesfalls aber sollte eine längere Therapiepause gemacht werden – die Auslösung eines Schubes der Grundkrankheit wäre eine mögliche kritische Folge. Für eine ausführlichere Einschätzung der Datenlage und der Konsequenzen daraus (auch in Bezug auf weitere DMARD [„disease-modifying anti-rheumatic drugs“]) wird auf die demnächst erscheinenden aktualisierten Handlungsempfehlungen der DGRh (Deutsche Gesellschaft für Rheumatologie e. V.) für die Betreuung von Patienten mit entzündlich rheumatischen Erkrankungen im Rahmen der SARS-CoV-2/COVID-19-Pandemie verwiesen.

Purpose of review Peptic ulcer disease (PUD) is a recognized complication of non-steroidal anti-inflammatory drugs (NSAIDs). Stress ulcers are a concern for intensive care unit (ICU) patients; PUD is also an issue for patients taking anticoagulation. Helicobacter pylori test and treat is an option for patients starting NSAID therapy, and proton pump inhibitors (PPIs) may reduce PUD in NSAID patients and other high-risk groups. Recent findings There are a large number of trials that demonstrate that Helicobacter pylori eradication reduces PUD in NSAID patients. PPI is also effective at reducing PUD in this group and is also effective in ICU patients and those on anticoagulants. The effect is too modest for PPI to be recommended in everyone, and more research is needed as to which groups would benefit the most. Increasing age, past history of PUD, and comorbidity are the most important risk factors. Summary H. pylori test and treat should be offered to older patients starting NSAIDS, while PPIs should be prescribed to patients that are at high risk of developing PUD and at risk of dying from PUD complications.

In 2006, a tumult arose in the world of fisheries. A controversial paper titled “Impacts of biodiversity loss on ocean ecosystem services” by Worm et al. (2006) was published in Science. The paper was sensational since it alluded to a prediction that global populations of marine fish (finfish and invertebrates) will be 100% collapsed by 2048. The paper was written by a group of marine ecologists and economists in which Boris Worm from Dalhousie University Canada led the authorship. After the paper was published, the issue of fish disappearance in 2048 became hot topics in the world’s mass media. In fact, the Worm et al. paper triggered the debates among researchers. Over time the debates heated up. Surprisingly, a reconciliation took place in 2009, marked by a collaboration between Worm’s team and his critics, writing another paper in Science. The present essay reaffirms the invalidity of the global collapse prediction in 2048 as revealed by many researchers. It is also shown that the Worm et al. paper did not state that all fish will disappear and through the joint paper in 2009, Worm and colleagues have indirectly rectified the prediction already.

Fused deposition modeling 3D printing is currently one of the hot topics in pharmaceutics and has shown a 2000% increase in the number of research articles published in the last 5 years. In the prospect of a new era of fused deposition modeling focused on the industrial development of this technique applied to the fabrication of personalized medicines, a conceptual map to move through the evolution of the design of the printed dosage forms/drug delivery systems was conceived and mainly discussed by means of graphical tools.

Developing cost-effective and high-performance hole transport materials (HTMs) is one of the hot topics in the researches of perovskite solar cells (PVSCs). By introducing a carboxyl group on the 3,4-ethylenedioxythiophene (EDOT) derivatives and replacing the –OCH3 (-OMe) groups on the Triphenylamine (TPA) derivatives to -N(CH3)2 groups, we present two efficient strategies for improving the performances of HTMs. The ground-state and excited-state properties, stabilities, solubilities and hole mobility of HTMs are comprehensively studied by DFT and TD-DFT. Both strategies have positive effects on the performance of HTMs. Two designed HTMs C1-R2 (μh = 1.05 × 10-2 cm2 V−1 s−1) and C2-R2 (μh = 1.9 × 10-3 cm2 V−1 s−1) show higher hole mobility than original HTMs C1-R1 (μh = 6.7 × 10-3 cm2 V−1 s−1) and C2-R1 (μh = 1.3 × 10-3 cm2 V−1 s−1) after the replacement on the TPA derivatives, which ensures the fact that these two designed HTMs have potentials in the application of PVSCs. It is hoped that our investigation can provide valuable strategies for conquering the predicament of the application and commercialization of PVSCs.

In a non-line-of-sight (NLOS) environment, ultra-wide band (UWB) high accuracy positioning has been one of the hot topics in studying indoor positioning. In this paper, a factor graph-based UWB positioning algorithm has been proposed based on an improved Turkey robust kernel. It has overcome not only the defect of the least squares algorithm for UWB positioning against non-Gaussian noise but also eliminated the shortcoming of Turkey robust kernel against over-optimization. Aiming at the character of UWB data generally larger than its true value due to barriers, robust kernel will be added into merely big ranging data. However, due to the presence of small ranging data possibly caused by error positioning, the squares of residuals will be taken as the optimized objective function. The experimental result proves that UWB positioning algorithm based on the improved Turkey robust kernel outperforms ordinary UWB positioning algorithms in NLOS environments, with the average positioning accuracy improved by around 20–30%.

Circular economy and electronic waste (e-waste) are among today's hot topics for scientists, environmentalists, and even policymakers. A considerable fraction of e-waste is waste printed circuit boards (WPCBs), which contains a wide range of metals, ceramics, and polymers. This variety of substances has made the recycling of WPCB an interesting challenge. Recently, there have been trends to not only recover WPCB into raw materials but also add extra value to final products by transforming the products into nanomaterials, catalysts, composites, etc. In this article, first, a practical model for adding value through recycling processes is defined, that is, the valorization model. Second, the recent studies that offered functional commodities extracted from WPCB, with an average value higher than traditional recycling methods, are reviewed and compared, to conclude a future projection for WPCB valorization.

Improving the catalytic performance of nanozymes is currently one of the hot topics in the field of analytical chemistry. Metal ions can be an ideal way for the regulation of enzyme activity becaus...

PURPOSE OF REVIEW: The decreased contact area, edge loading, and increased stress in the adjacent area cartilage resulting from chondral defects are believed to predispose this tissue to degenerative changes that have significant economic implications, especially when considering its progression to osteoarthritis of the knee. Growth factors are considered therapeutic possibilities to enhance healing of chondral injuries and modify the progression to degenerative arthritis. Thus, the purposes of this review are to first to summarize important points for defect preparation and recent advances in techniques for marrow stimulation and second, and to identify specific growth factors and cytokines that have the capacity to advance cartilage regeneration and the treatment of osteoarthritis in light of recent laboratory and clinical studies. RECENT FINDINGS: TGF-β, BMP-2, BMP-7, IGF-1, as IL-1 receptor antagonist, and recombinant human FGF-18 are some of the promising growth factor/cytokine treatments with pioneering and evolving clinical developments. The bulk of the review describes and discusses these developments in light of fundamental basic science. It is crucial to also understand the other underlying advances made in the surgical management of cartilage defects prior to onset of OA. These advances are in techniques for defect preparation and marrow stimulation, a common cartilage repair procedure used in combination with growth factor/cytokine augmentation. SUMMARY: Multiple growth factor/cytokine modulation therapies are currently undergoing clinical trial investigation including Invossa (currently in phase III study), Kineret (currently in phase I study), and Sprifermin (currently in phase II study) for the treatment of symptomatic osteoarthritis.

PURPOSE OF REVIEW: Particularly common in collision sports such as American football or rugby, stingers are a traumatic transient neuropraxia of a cervical nerve root(s) or brachial plexus that may last anywhere from minutes to hours. This review summarizes the knowledge on the diagnosis and management of stingers in college and professional collision athletes by providing an overview of their epidemiology and pathophysiology, followed by a discussion on current treatment guidelines and return-to-play recommendations. RECENT FINDINGS: Despite modifications to tackling technique, increasing awareness, and various equipment options, American football continues to have a high rate of cervical spine injuries, the majority of which occur in preseason and regular season competition settings. The incidence of stingers has slowly increased among collision athletes, and nearly half of all players report sustaining at least one stinger in their career. Recent studies have shown certain anatomical changes in the cervical spine are related to acute and reoccurring stingers. Most players who experience stingers do not miss practices or games. SUMMARY: Despite their prevalence, literature highlighting the impact of stingers on college and professional collision athletes is limited. Advances in imaging modalities and novel radiographic parameters have provided tools for screening athletes and can guide return-to-play decisions. Future research regarding appropriate screening practices for athletes with reoccurring stingers, use of protective equipment, and rehabilitation strategies are needed to identify predisposing factors, mitigate the risk of injury, and restore full functional strength and ability.

Scholars and practitioners of international development often note the use of ‘development buzzwords’: terms that represent hot topics in the field. Buzzwords characterise a development issue and imply elements of possible solutions. This article analyses the prevalence of these words in development discourse, asking who among donors, major nongovernmental organisations (NGOs), or academics adopts buzzwords earliest and uses them the most. We also analyse how these actors use buzzwords–whether buzzwords represent new ideas or essentially repackage old concepts. The article compares the prevalence of buzzwords among three bodies of text published since 1990: social science journal articles on NGOs; World Bank annual reports; and the annual reports of BRAC, Save the Children, and World Vision. Using topic modelling and keyword searches, we trace how the terms ‘reproductive health,’ ‘gender,’ ‘participatory development,’ and ‘accountability’ ebbed and flowed over these literatures. We find suggestive evidence against ‘donor-driven development’: buzzwords appear first in academic literature and the annual reports of NGOs, followed by the World Bank. We also find evidence that international conferences and emergent health crises influence buzzword use. We conclude that buzzwords’ function and fates vary, with some losing priority, others losing substance, and yet others persisting as multivalent concepts.

The 5th International Porto Congress of Multiple Sclerosis took place between the 14th and 16th of February 2019 in Porto, Portugal. Its intensive programme covered a wide-range of themes—including many of the hot topics, challenges, pitfalls and yet unmet needs in the field of multiple sclerosis (MS)—led by a number of well-acknowledged world experts. This meeting review summarizes the talks that took place during the congress, which focussed on issues in MS as diverse as the development and challenges of progressive MS, epidemiology, differential diagnosis, medical management, molecular research and imaging tools.

The diffusion of new product information in firm–hosted online communities depends on the information interaction between users. Especially in the early stage of new product online sales, user influence based on interactive behavior is the critical factor that affects the wide and sustainable diffusion of new product information, makes users respond to firm’s announcement of new product releases in time, and improves the new product competitiveness. Since very little work has been done on the effect of user influence on the new product information diffusion, this paper proposes a model based on user influence for the diffusion of new product information in firm–hosted online communities to fill this gap. Moreover, focusing on the hot topics of new product innovation functions, we present a new method to measure user influence from the perspective of user interaction, which provides a quantitative theoretical basis for the diffusion probability of influencing user state change in new product information diffusion. Finally, our model tests a well–known firm–hosted online community in China. The results reveal that the model can effectively describe the dynamic evolution of information diffusion, explain the key dynamic factors, and accurately predict the peak time of information diffusion.

Population ageing, together with urbanisation, has become one of the greatest challenges throughout the world in the 21st century. Approximately one million people turn 60 each month worldwide. By 2050, more than 20 per cent of the global population is predicted to be 60 years old or above. Thus, an increasing need is evident for age-friendly communities, services and structures. Numerous studies on age-friendly cities and communities (AFCCs) have been conducted over the past decade. The large volume literature makes it necessary to figure out key areas and the evolution trends of studies on AFCCs. Therefore, this paper aims to provide a comprehensive review of existing literature pertaining to AFCCs. A total of 231 collected publications are analysed and visualised by CiteSpace. According to the keywords and document co-citation networks that are generated, the foundation, hot topics and domains of AFCC research are grouped. Three major themes, namely the characteristics of AFCCs, the application of the World Health Organization's framework in urban and rural areas worldwide, and the measurement of cities’ and communities’ age-friendliness, are identified. In addition, a roadmap of AFCC research is developed. The results of this research will therefore benefit researchers and practitioners.

PURPOSE OF REVIEW: Advances in technology, implant design, and surgical technique have lowered the dislocation rate in primary total hip arthroplasty (THA). Despite these advances, there remain a large number of instability episodes without a known etiology. Recent research suggests that the pelvic and lumbar spine interrelationship may be the explanation in prosthetic dislocations without a known cause. In this review, we describe the biomechanics, measurements, diagnoses, classification, management, and outcomes of total hip and revision total hip instability as it relates to spinopelvic alignment. RECENT FINDINGS: As a person goes from standing to sitting, lumbar lordosis decreases, and the sacrum and entire pelvis tilts posteriorly with sacrum and coccyx rotating posterior-inferiorly, resulting in increased acetabular cup anteversion to accommodate femoral flexion. A fused spine and associated fixed acetabulum can result in abnormal pelvic femoral motion, impingement, and dislocation. Classifying the spinopelvic mechanics by sacral motion based on sitting and standing lateral radiographs provides an understanding of how the acetabulum behaves in space. This information helps appropriate cup positioning, reducing the risk of femoral side impingement and subsequent dislocation. SUMMARY: Surgical techniques to consider in the spinopelvic at-risk patient are positioning considerations in acetabular cup inclination and anteversion, high offset femoral stems, high offset acetabular liners, dual mobility articulations, and removal of impinging structures. Future research is needed to define the safest order of operation in concomitant hip and spine pathology, the effects on pelvic femoral biomechanics in spine surgery, and whether preoperative and intraoperative management strategies have a long-term beneficial effect on the dislocation rate.

Sufficient data presence is one of the key preconditions for applying metrics in practice. Based on both Altmetric.com data and Mendeley data collected up to 2019, this paper presents a state-of-the-art analysis of the presence of 12 kinds of altmetric events for nearly 12.3 million Web of Science publications published between 2012 and 2018. Results show that even though an upward trend of data presence can be observed over time, except for Mendeley readers and Twitter mentions, the overall presence of most altmetric data is still low. The majority of altmetric events go to publications in the fields of Biomedical and Health Sciences, Social Sciences and Humanities, and Life and Earth Sciences. As to research topics, the level of attention received by research topics varies across altmetric data, and specific altmetric data show different preferences for research topics, on the basis of which a framework for identifying hot research topics is proposed and applied to detect research topics with higher levels of attention garnered on certain altmetric data source. Twitter mentions and policy document citations were selected as two examples to identify hot research topics of interest of Twitter users and policy-makers, respectively, shedding light on the potential of altmetric data in monitoring research trends of specific social attention.

PURPOSE OF REVIEW: The purpose of this systematic review is to evaluate the current literature in patients undergoing spine surgery in the cervical, thoracic, and lumbar spine to determine the available risk assessment tools to predict the patient-centered outcomes of pain, disability, physical function, quality of life, psychological disposition, and return to work after surgery. RECENT FINDINGS: Risk assessment tools can assist surgeons and other healthcare providers in identifying the benefit-risk ratio of surgical candidates. These tools gather demographic, medical history, and other pertinent patient-reported measures to calculate a probability utilizing regression or machine learning statistical foundations. Currently, much is still unknown about the use of these tools to predict quality of life, disability, and other factors following spine surgery. A systematic review was conducted using PRISMA guidelines that identified risk assessment tools that utilized patient-reported outcome measures as part of the calculation. From 8128 identified studies, 13 articles met inclusion criteria and were accepted into this review. SUMMARY: The range of c-index values reported in the studies was between 0.63 and 0.84, indicating fair to excellent model performance. Post-surgical patient-reported outcomes were identified in the following categories (n = total number of predictive models): return to work (n = 3), pain (n = 9), physical functioning and disability (n = 5), quality of life (QOL) (n = 6), and psychosocial disposition (n = 2). Our review has synthesized the available evidence on risk assessment tools for predicting patient-centered outcomes in patients undergoing spine surgery and described their findings and clinical utility.

PURPOSE OF REVIEW: The use of cannabinoids has increased since legalization of recreational and medical use in the USA. It is likely that many orthopaedic patients consume cannabinoid products during the traumatic or perioperative period. The purpose of this study was to investigate the pre-clinical data evaluating the mechanism of action of cannabidiol (CBD) and Δ(9)-Tetrahydrocannabinol (Δ(9)-THC) and to evaluate the current clinical data on the use of cannabinoids in musculoskeletal illness. RECENT FINDINGS: Recent pre-clinical studies have demonstrated that cannabinoid use and the endocannabinoid system (ECS) has an important role in bone healing and bone homeostasis. There is data that suggests that the use of cannabidiol (CBD) may increase bone healing, whereas the use of Δ(9)-Tetrahydrocannabinol (Δ(9)-THC), the major psychoactive ingredient in marijuana, likely inhibits bone metabolism and repair. The clinical implications and consumption of marijuana by orthopaedic patients have not been thoroughly evaluated. Studies have demonstrated concern for negative cardiovascular and psychiatric effects caused by marijuana use, but have not yet elucidated outcomes in the orthopaedic literature. SUMMARY: With the recent increase in advertising of CBD products and legalization of marijuana, it is likely that many orthopaedic patients are consuming cannabinoid products. The clinical implications and consumption of these products are unclear. We need more robust and well-designed clinical studies prior to making further recommendations to our patients on the consumption of these products.

This special issue of the European Journal of Physics: Special Topics entitled Celestial Mechanics in the XXIst Century published a set of 15 papers aiming to put in perspective the main problems that are being addressed by the researchers in this area. Our goal is to draw attention to the challenges that they represent so that new approaches may be conceived to foster better and more effective solutions of them. In particular, it is shown points related to a new type of creep tide theory, studies related to the risk of collision of space vehicles with space debris, motion near NEAs, strategies to avoid a collision of an asteroid with the Earth and decay of small satellites in the atmosphere of the Earth are included, since they are hot topics of current research.

Considerable advances have been made from diverse perspectives in rockburst research to guarantee the safety of deep underground activities. However, to date, few reviews have been made to systematically analyze the overall research status of rockburst. This study is aimed at providing a scientometric review on rockburst research in hard rock from 2000 to 2019. First, a total of 430 papers were collected from the Web of Science Core Collection database. Then, the CiteSpace software was adopted to conduct a scientometric analysis from five main aspects. Finally, the existing knowledge domains and future directions were discussed. Based on the results of this study, main countries, institutions, authors, and journals of rockburst research were revealed, and some important papers, hot topics, and evolutionary trends were found out. This review contributes to the integrated knowledge map of rockburst research in hard rock and provides researchers a valuable and in-depth understanding in this domain.

Several studies have demonstrated that exosomes have a very broad prospect in the field of cancer therapy. This study aims to identify the general characteristics, cooperation of authors, countries and explore the hot topics of the top 100 cited articles on tumor-related exosomes. We searched the Web of Science Core Collection on June 28, 2019, to collect related publications. Microsoft Excel 2016 and VOSviewer 1.6.9 were applied to analyze the publication year, citations, authors, countries, institutions, journals, and keywords. The top 100 articles were published between 1998 and 2017 with citations ranging from 181 to 2275. Cancer Research (n = 9) had the highest number of publications. Nature Cell Biology, Nature, and Nature Medicine are considered to be the core journals of tumor-related exosomes because they are among top 10 from different analytical perspectives. The USA (n = 49) and Harvard University (n = 9) were the most productive country and institution, respectively. There were active collaborations between countries. Kalluri R (n = 6) contributed the largest number of articles, and Taylor DD was the most co-cited author. Théry C and Al-Nedawi K are probably the two important experts as they are both the top 10 authors and top 10 co-cited authors. Three clusters were obtained after clustering analysis of the keywords. The main hot topics were the proteomic analysis and mechanism of vesicle activation and the role of exosomes in the diagnosis and progression of tumors. Further research should expand and develop new topics such as the role of exosomes in the treatment of cancers.

The origins and prehistoric spread of rice agriculture between East and West Asia are hot topics in the current archaeological community. In this study, we present the results from a preliminary archaeobotanical study at the Khalchayan site in Uzbekistan, where we recovered the oldest securely dated rice thus far identified in Central Asia. We directly dated the rice grains to 1714-1756 cal yr BP (Kushan period), and morphologically compared them with other contemporaneous cultivated rice remains from China and India. The morphological results showed that the rice remains found at Khalchayan are more similar to cultivated japonica rice from southern China and northwestern India. Integrated archeological and chronological results from the surrounding area show that the rice remains found at Khalchayan likely spread along a southern Himalayan route from southwest China to northern India and finally reached the Amu Darya. The rice remains from Khalchayan are the first directly dated and well-reported rice remains found in Central Asia. By the Islamic period, rice was an important culinary aspect of the culture in Central Asia, but the cultural affinity towards rice only developed over the past two millennia. This study provides new information on the spread of rice agriculture globally, especially in arid-semiarid inland regions.

For the purpose of evaluating scientific output, examining literature utilization, and predicting the direction of publication for Journal of King Saud University – Science (JKSU-S). This paper explored the hot topics and new trends through the statistics of the journal between 2009 and 2019 from the perspective of bibliometric and visualization technologies. After excluding letters, book reviews, editorial materials, proceedings papers, etc., 543 valid records were screened out from Scopus database ultimately. The data were analyzed and mapped in terms of dynamics and trends of publications, productive and influential contributors and thematic and hot topic change, etc. Through these results, we also concluded the findings from these three aspects and presented a comprehensive picture of the journal. Correspondingly, this paper also provided the suggestion to authors, editorial board, publishers involved based on the findings. Keywords: Bibliometric analysis, Journal of King Saud University – Science, Evolution and thematic changes, Visualized review, Publishing service

In network public-opinion analysis, the diversity of messages under social hot topics plays an important role in user participation behavior. Considering the interactions among multiple messages and the complex user behaviors, this article proposes a prediction model of user participation behavior during multiple messaging of hot social topics. First, considering the influence of multimessage interaction on user participation behavior, a multimessage interaction influence-driving mechanism was proposed to predict user participation behavior more accurately. Second, in the view of the behavioral complexity of users engaging in multimessage hotspots and the simple structure of backpropagation (BP) neural networks (which can map complex nonlinear relationships), this study proposes a user participant behavior prediction model of social hotspots based on a multimessage interaction-driving mechanism and the BP neural network. Finally, the multimessage interaction has an iterative guiding effect on user behavior, which easily causes overfitting of the BP neural network. To avoid this problem, the traditional BP neural network is optimized by a simulated annealing algorithm to further improve the prediction accuracy. In evaluation experiments, the model not only predicted the user participation behavior in actual situations of multimessage interaction but also further quantified the correlations among multiple messages on hot topics.

Aim: Our study aimed to analyze the characteristics of papers published on CAR T-cell in the field of cancer and explore the existing hot topics and prospects. Materials & methods: We explored the global hotspots and future prospects regarding CAR T-cell therapy in cancer research. Papers of CAR T-cell research were retrieved from the Web of Science database. Analysis was performed using VOSviewer, CiteSpace and Excel software. Results: A total number of 1994 papers related to CAR T-cell research of cancer were included. Molecular Therapy published the most papers (n = 85, 4.26%). A total of 9792 authors participated in the publication of all papers. 62 countries and 2065 institutions have participated in the publication of all papers. Conclusion: Research trends are to improve the immunosuppressive microenvironment of cancer, optimize the structure of CAR T-cells and develop ‘super CAR T-cell’ by using gene-editing technology.

The surgical management of patients with congenital diaphragmatic hernia (CDH) is challenging and ever changing. It requires the highest expertise not only on the surgical level but also of neonatologists and anesthesiologists. In selected patients traditional open surgery is increasingly replaced by thoracoscopic CDH repair in many centers worldwide. Despite obvious and well-described advantages of the minimally invasive approach like a shorter ventilatory time, less pain, a shorter hospital length of stay, and a better cosmesis, important controversies remain. This review discusses hot topics of minimally invasive CDH repair, such as extracorporeal membrane oxygenation, hypercapnia/acidosis, patch repair, surgical training, and recurrence.

This unique clinical case illustrates several “hot topics” of NSCLC management in one patient including correct staging and treatment of IIIA(N2) stage, neoadjuvant immunotherapy with phenomenon of pseudoprogression, VATS segmentectomy for peripheral stage IA NSCLC with good outcome.

The advent of the big data era has opened up unprecedented quantifiable dimensions for all walks of life, while also presented many opportunities and challenges. The widespread application of big data in the field of education will inevitably promote the innovation and transformation of the higher education in colleges and universities which introduce new opportunities and challenges to personalized education in colleges and universities. How to promote the in-depth integration of big data and higher education to meet the needs of students' personalized development is one of the hot topics in the theoretical field today. In view of this, this article starts with explaining the connotation of personalized education in colleges and universities, analyzes the opportunities and challenges faced by personalized education in colleges and universities under the context of big data, and proposes the ideas of innovating personalized education in colleges and universities under the comntext of big data.