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OBJECTIVE: To explore whether kidney Yang deficiency (KYD) is prone to metabolic disorders may be linked to impaired mitochondrial function in thermogenesis and metabolic tissues. METHODS: A rat model of KYD was used, which was established using Sprague Dawley rat dams with warm preference subjected to herbal treatment that can improve kidney Yang. The human relevance was confirmed by reduced serum corticosterone levels, and increased preference for warm location. RESULTS: KYD Rats were underdeveloped. Adenosine-triphosphate (ATP) production was reduced in the brown fat, but increased in the muscle. However, oxidative phosphorylated complexes to generate ATP and mitochondrial biogenesis marker were reduced in both tissues. When the second insult of high-fat diet (HFD) was introduced, KYD rats gained less weight yet developed more severe lipid and glucose metabolic disorders. This may be driven by disregulated liver gluconeogenesis marker forkhead box protein O1 and lipid metabolic regulator cholesterol 7 alpha-hydroxylase. CONCLUSIONS: KYD rats exhibited reduced mito-chondrial function in the brown fat, but were partially compensated by skeletal muscle, associated with the phenotype of warm preference and metabolic disorder, which was further exacerbated by additional HFD consumption. Future studies can focus on treatment targetting mitochondria function to reverse this phenotype.

Background. Sensitive indicators of nursing quality focus on the core elements of nursing quality management. Nursing-sensitive quality indicators will play an increasingly important role in the macro and micro management of nursing quality in my country. Objective. This study were aimed at formulating the sensitive index management of orthopedic nursing quality based on individual nurses for improvement of the quality of orthopedic nursing. Methods. Based on the previous literature, the existing challenges in the early application of the orthopedic nursing quality evaluation index were summarized. Moreover, the management system of the orthopedic nursing quality-sensitive index based on individual nurses was devised and implemented, including monitoring the structure and result indices of individual nurses on duty and sampling the process indicators of patients managed by individual nurses. At the quarter-end, the data analysis was performed and fed back to determine the key points of the changes in the quality of specialized nursing affecting the individual, and the PDCA method was utilized for persistent improvement. The changes of sensitive indices of orthopedic nursing quality before (July-December 2018) and 6 months after implementation (July-December 2019) were compared. Results. There were significant differences in other indices (accuracy of limb blood circulation assessment/accuracy of pain assessment/postural care pass rate/accuracy of rehabilitation behavioral training/satisfaction of discharged patients) ( P < 0.05 ). Conclusion. The formulation of an individual-based orthopedic nursing quality-sensitive index management system modifies the traditional quality management model, improves the specialized nursing level, contributes to the accurate core competence training of specialized nursing, and improves the quality of specialized nursing of individual nurses. Consequently, there is an overall improvement in the specialized nursing quality of the department, and fine management is attained.

Additional file 3: The calculation for covariance components within population, among population/within group, and among populations.

Additional file 2: Alignment of the complete mt genomes identified 33 SNPs from Hainan.

Additional file 4: Haplotypes in all geographical location.

Supplemental Material for Clinical efficacy of ZelanteDVT™ catheter rheolytic thrombectomy in the single-session treatment of patients with subacute deep venous thrombosis by Da Li, Xiaosong Zhang, Yusheng Wang, Hao Tang, He Huang, Xiaomin Huang, and Honggang Zhang in Phlebology.

Additional file 1: Primer sequences. Primers used for amplifying and sequencing the mitochondrial genome of Plasmodium vivax.

“Vadim” is the first experience of Mikhail Lermontov in prose. Some Russian scholars define it as ahistorical novel. The combination of themes of individual revenge with the theme of peasant revolt is a peculiar feature of “Vadim”. The author of the novel raises the question of the origin of evil, presupposed by “heocracy”, and by analyzing the hero Vadim’s revenge motive, the anti-theodicy’s narrative mechanism of the novel can be explained. The scene in which the hero abets his companion to hang the captured old man is a direct experiment of anti- theodicy and a powerful testimony of the writer's anti- theodicy standpoint. According to Leibniz’s theory, Vadim's evil belongs to moral evil. Lermontov’s view of good and evil echoes Leibniz’s theory. Leibniz believes that evil exists to show good and make it the object of opposition, and that man can achieve perfection in the process of winning good over evil. From the novel two righteous images — the nameless old man and the wife of a soldier, persisted in their beliefs in times of crisis, which showed the writer’s inheritance of theodicy’s standpoint. Before hanging, the nameless old man recalls the death of Jesus Christ and at the last moment of his life still believed that Jesus had conquered death. The scene of the torture of a soldier’s wife resembles the “martyrdom of the righteous”. For the truth, for what she believes, she is willing to sacrifice herself. This is the proof of the two repeated verses in the novel: “Come to me all you who labor and are burdened, and I will give you rest”. Lermontov’s theological view in “Vadim” is paradoxical.