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950 results on '"Ishikawa, Hiroki"'

152. Scanning electoronmicroscopical analysis of the loose bodies of synovial chondoromatosis in temporomandibular joint

Author

Yoshida, Hiroaki, primary, Tsuji, Kaname, additional, Ishikawa, Hiroki, additional, Nakayama, Masayuki, additional, Yamamoto, Makoto, additional, Takasugi, Norifumi, additional, Ikeda, Hayato, additional, Kitayoshi, Marina, additional, Tani, Mitsuru, additional, Iseki, Tomio, additional, Ueda, Katsura, additional, and Tamura, Isao, additional

Published
2019
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157. Impact of Relative Dose Intensity of Early-phase Lenvatinib Treatment on Therapeutic Response in Hepatocellular Carcinoma

Author

TAKAHASHI, AYA, primary, MORIGUCHI, MICHIHISA, additional, SEKO, YUYA, additional, ISHIKAWA, HIROKI, additional, YO, TAKAHARU, additional, KIMURA, HIROYUKI, additional, FUJII, HIDEKI, additional, SHIMA, TOSHIHIDE, additional, MITSUMOTO, YASUHIDE, additional, ISHIBA, HIROSHI, additional, TAKASHIMA, HIDETAKA, additional, NAGAO, YASUYUKI, additional, JO, MASAYASU, additional, ARAI, MASAHIRO, additional, HARA, TASUKU, additional, OKAJIMA, AKIRA, additional, MURAMATSU, AKIRA, additional, MORITA, ATSUHIRO, additional, YOSHINAMI, NAOMI, additional, NAKAJIMA, TOMOKI, additional, MITSUYOSHI, HIRONORI, additional, UMEMURA, ATSUSHI, additional, NISHIKAWA, TAICHIRO, additional, YAMAGUCHI, KANJI, additional, and ITOH, YOSHITO, additional

Published
2019
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166. Novel cGMP Signaling Pathway that Modulates NF-κB Activation in Innate Immune Responses

Author

Kanoh, Hirotaka, primary, Iwashita, Shinzo, additional, Kuraishi, Takayuki, additional, Goto, Akira, additional, Ueno, Haruna, additional, Watanabe, Ryo, additional, Hori, Aki, additional, Momiuchi, Yoshiki, additional, Ishikawa, Hiroki, additional, Suzuki, Hiroaki, additional, Nabe, Kumiko, additional, Takagaki, Takeshi, additional, Fukuzaki, Masataka, additional, Tong, Li-Li, additional, Fuse, Naoyuki, additional, Oshima, Yoshiteru, additional, Aigaki, Toshiro, additional, Dow, Julian A. T., additional, Davies, Shireen-Anne, additional, and Kurata, Shoichiro, additional

Published
2019
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167. Molecular and virulence characteristics of an outer membrane-associated RTX exoprotein in Pasteurella pneumotropica

Author

Kawamoto Eiichi, Amao Hiromi, Sekiguchi Satoshi, Sato Toru, Ishikawa Hiroki, Sasaki Hiraku, Matsumoto Tetsuya, and Shirama Kazuhiko

Subjects
Microbiology, QR1-502
Abstract

Abstract Background Pasteurella pneumotropica is a ubiquitous bacterium that is frequently isolated from laboratory rodents and causes various clinical symptoms in immunodeficient animals. Currently two RTX toxins, PnxIA and PnxIIA, which are similar to hemolysin-like high-molecular-weight exoproteins are known in this species. In this study, we identified and analyzed a further RTX toxin named PnxIIIA and the corresponding type I secretion system. Results The RTX exoprotein, PnxIIIA, contains only a few copies of the RTX repeat-like sequence and 3 large repeat sequences that are partially similar to the outer membrane protein found in several prokaryotes. Recombinant PnxIIIA protein (rPnxIIIA) was cytotoxic toward J774A.1 mouse macrophage cells, whereas cytotoxicity was attenuated by the addition of anti-CD11a monoclonal antibody. rPnxIIIA could bind to extracellular matrices (ECMs) and cause hemagglutination of sheep erythrocytes. Binding was dependent on the 3 large repeat sequences in PnxIIIA. Protein interaction analyses indicated that PnxIIIA is mainly localized in the outer membrane of P. pneumotropica ATCC 35149 in a self-assembled oligomeric form. PnxIIIA is less cytotoxic to J774A.1 cells than PnxIA and PnxIIA. Conclusions The results implicate that PnxIIIA is located on the cell surface and participates in adhesion to ECMs and enhanced hemagglutination in the rodent pathogen P. pneumotropica.

Published
2011
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168. Prevalence and analysis of Pseudomonas aeruginosa in chinchillas

Author

Aoyama Naoki, Matsumoto Tetsuya, Ishikawa Hiroki, Kawamoto Eiichi, Sasaki Hiraku, Hirakawa Yasuko, Kawasumi Koh, and Amao Hiromi

Subjects
Veterinary medicine, SF600-1100
Abstract

Abstract Background Chinchillas (Chinchilla laniger) are popular as pets and are often used as laboratory animals for various studies. Pseudomonas aeruginosa is a major infectious agent that causes otitis media, pneumonia, septicaemia enteritis, and sudden death in chinchillas. This bacterium is also a leading cause of nosocomial infections in humans. To prevent propagation of P. aeruginosa infection among humans and animals, detailed characteristics of the isolates, including antibiotic susceptibility and genetic features, are needed. In this study, we surveyed P. aeruginosa distribution in chinchillas bred as pets or laboratory animals. We also characterized the isolates from these chinchillas by testing for antibiotic susceptibility and by gene analysis. Results P. aeruginosa was isolated from 41.8% of the 67 chinchillas included in the study. Slide agglutination and pulsed-field gel electrophoresis discriminated 5 serotypes and 7 unique patterns, respectively. For the antibiotic susceptibility test, 40.9% of isolates were susceptible to gentamicin, 77.3% to ciprofloxacin, 77.3% to imipenem, and 72.7% to ceftazidime. DNA analyses confirmed that none of the isolates contained the gene encoding extended-spectrum β-lactamases; however, 2 of the total 23 isolates were found to have a gene similar to the pilL gene that has been identified in the pathogenicity island of a clinical isolate of P. aeruginosa. Conclusions P. aeruginosa is widely spread in chinchillas, including strains with reduced susceptibility to the antibiotics and highly virulent strains. The periodic monitoring should be performed to help prevent the propagation of this pathogen and reduce the risk of infection from chinchillas to humans.

Published
2010
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172. Penicillin-Binding Proteins and Associated Protein Mutations Confer Oxacillin/Cefoxitin Tolerance in Borderline Oxacillin-Resistant Staphylococcus aureus.

Author

Sasaki, Hiraku, Ishikawa, Hiroki, Itoh, Taisuke, Arano, Makoto, Hirata, Koya, and Ueshiba, Hidehiro

Subjects
*PENICILLIN-binding proteins, *CEFOXITIN, *OXACILLIN, *BETA lactamases, *PROTEINS, *CLINDAMYCIN
Abstract

Among clinical isolates of Staphylococcus aureus, borderline oxacillin-resistant S. aureus (BORSA), which is mildly resistant to oxacillin (OXA) without harboring the mecA or mecC gene, is considered a risk factor for further resistance against multiple antibiotics. In this study, BORSA isolates and their derivatives were characterized through antibiotic susceptibility testing and mutation analysis of the genes encoding penicillin-binding proteins (PBPs) and their related proteins, including the promoter region. Eight BORSA isolates were confirmed to harbor the blaZ gene, and hyperproduction of blaZ-encoded penicillinase was predicted based on the minimum inhibitory concentrations (MICs). Of these, four derivative strains that were spontaneously selected based on viability on media containing high concentrations of OXA showed higher MICs than the parent isolates. The minimum bactericidal concentrations, MIC ratios, and TDtest results identified many strains with cefoxitin tolerance. Sequencing of pbp1, pbp2, pbp3, pbp4, gdpP, and yjbH, and the promoter of pbp4 revealed mutations in BORSA isolates and derivatives, despite their absence in parent isolates, suggesting that mutations in PBPs confer OXA/cefoxitin tolerance in BORSA strains. [ABSTRACT FROM AUTHOR]

Published
2021
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181. Standard models for Power Electronic System Simulation

Author

Shigematsu, Koichi, primary, Ishikawa, Hiroki, additional, Noda, Taku, additional, Fukushima, Kentarou, additional, Sekiba, Yoichi, additional, Kouno, Yusuke, additional, Abe, Takashi, additional, Sekisue, Takayuki, additional, and Katoh, Shinji, additional

Published
2018
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192. Enlargement of accessory spleen subsequent to splenectomy associated with gastrectomy can mimic a solitary tumor : report of a case

Author

Ishibashi, Haruaki, Mukaisho, Ken-ichi, Wakabayashi, Masato, Takeuchi, Takayuki, and Ishikawa, Hiroki

Abstract

We report a case of a 65-year-old woman with an incidental about 20-mm solitary mass between the lateralsegment of the left lobe of the liver and left kidney 5 years after splenectomy associated with total gastrectomy. The mass wassurgically resected, and histological examination revealed it to be an accessory spleen. Small accessory spleens mostly locatednear the splenic hilus, but large accessory spleens are unusual after total gastrectomy with regional lymph nodes resection. Theremaining accessory splenic tissue would undergo compensatory hypertrophy. Hence, the possibility of accessory spleens mustbe considered when an intra-abdominal mass is identified in a patient with splenectomy associated with gastrectomy.

Published
2011

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